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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-11-15T16:59:01.672">November 15, 2024</time></div><h1 class="text-[26px] font-medium leading-8"> RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/kennedy-ferruggia">Kennedy Ferruggia</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title=" RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" 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21px; } .rhap_volume-button { // width: 5px; // height: 5px; flex: 0 0 26px; position: relative; left: 22px; bottom: 21px; } .rhap_volume-button svg { height: 18px; width: 18px; } .rhap_volume-indicator { height: 8px; width: 8px; top: -2.75px } .rhap_button-clear { color: rgb(0,55,103) !important; } .rhap_play-pause-button { color: rgb(0,55,103) !important; font-size: 30px !important; width: 30px !important; height: 30px !important; position: relative; right: 90px; bottom: 22px; } .rhap_main-controls button { color: rgb(0,55,103) !important; } audio::-webkit-media-controls-play-button, video::-webkit-media-controls-play-button { -webkit-appearance: media-play-button; color: #b8dcf6; } audio::-webkit-media-controls-panel { background-color: white !important; color: #000; } audio::-webkit-media-controls-current-time-display, audio::-webkit-media-controls-time-remaining-display { font-size: 12px; } </style></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><div class="w-full flex flex-col px-4 py-4 border-t border-b border-solid border-gray-400 my-4 "><h3 class="text-primary text-xl font-semibold">Key Takeaways</h3><ul class="list-disc px-8"><li class="py-2 "> RSV vaccines showed 80% effectiveness against hospitalizations and 81% against critical illness in non-immunocompromised individuals aged 60 and older. </li><li class="py-2 "> Immunocompromised individuals experienced 73% vaccine effectiveness against hospitalizations and 77% against emergency department encounters. </li><li class="py-2 hidden"> The study utilized a test-negative design analysis across eight US states, confirming vaccine efficacy with real-world data. </li><li class="py-2 hidden"> The findings underscore the success of RSV vaccines in the 2023-2024 season, following their approval and CDC recommendations.</li></ul><span class="text-xs font-bold text-primary underline cursor-pointer mt-2 ml-4">SHOW MORE</span></div><p class="py-2 mb-2 text-sm italic text-gray-600">Respiratory syncytial virus (RSV) vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults, study finds. </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">This article was originally published on <a target="_blank" href="https://www.pharmacytimes.com/"><em>Pharmacy Times</em></a>®<em>. </em></p><p class="pb-2"><em></em></p><div class=""><div style="width:35%;float:left;max-width:525px;margin:0 1.5rem 1.5rem 0;clear:both;cursor:" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%277360%27%20height=%274912%27/%3e"/></span><img alt="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" title="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" title="Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 1x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fd1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2"><div style="text-align:center">The findings suggest that RSV vaccination was proved to be 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season. | Image credit: JUN LI - stock.adobe.com</div></p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">A new study findings published in <a rel="nofollow noreferrer noopener" target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/39426837/"><em>The Lancet</em></a> assessed the effectiveness of respiratory syncytial virus (RSV) vaccines against RSV-associated hospitalizations and emergency department encounters among individuals at least 60 years of age. The study was conducted to confirm RSV vaccine effectiveness found in clinical trials against lower respiratory tract disease using real world data.<sup class="text-inherit">1</sup></p><p class="pb-2"><sup class="text-inherit"></sup></p><p class="pb-2">According to the CDC, the US experiences up to 160,000 hospitalizations and around 10,000 deaths among older adults due to RSV infection each year. Symptoms typically present like a mild cold but could become more severe among older adults.<sup class="text-inherit">2</sup></p><p class="pb-2"></p><p class="pb-2">In June of 2023, the CDC recommended individuals 60 years and older to receive an RSV vaccine after proving to be effective against RSV-associated lower respiratory tract disease in clinical trials.<sup class="text-inherit">1,2 </sup>The trials displayed that RSVPreF3 (Arexvy; GSK) provided 87.5% efficacy against RSV-associated lower respiratory tract disease and RSVpreF (Abrysvo; Pfizer) provided 84.6% efficacy.<sup class="text-inherit">3</sup></p><p class="pb-2"><sup class="text-inherit"></sup></p><p class="pb-2">However, researchers found that there was limited real-world data on the vaccine’s effectiveness. To address the gaps in research from the clinical trials, investigators assessed hospitalizations and emergency department encounters among individuals that reported RSV illness for patients that were at least 60 years of age.<sup class="text-inherit">1,2</sup></p><p class="pb-2"><sup class="text-inherit"></sup></p><p class="pb-2">The researchers conducted a test-negative design analysis in an electronic health records-based network in 8 US states, which contributed data on inpatient, emergency department, and urgent care encounters among individuals that experienced RSV-associated illness from October 1, 2023, to March 31, 2024. The study authors noted that status of RSV vaccination was confirmed from electronic health record documents, state and city immunization registries, and medical claims.<sup class="text-inherit">1,3</sup></p><p class="pb-2"><sup class="text-inherit"></sup></p><p class="pb-2">According to the study authors, vaccine effectiveness was measured by an individual’s immunocompromised status, which compared the odds of vaccination among RSV-positive cases and RSV-negative cases. The estimated effectiveness was adjusted for age, race, ethnicity, sex, calendar day, social vulnerability index, amount of non-respiratory medical conditions, presence of underlying respiratory medical conditions, and geographical region.</p><p class="pb-2"></p><p class="pb-2">The results found that, among 28,271 hospitalizations for RSV-like illness in individuals at least 60 years of age and were not immunocompromised, vaccine effectiveness was 80% against RSV-associated hospitalizations and 81% effective against RSV-associated critical illness. Further results found that vaccine effectiveness was 73% among 8435 individuals that were immunocompromised. Additionally, among 36,521 emergency department encounters for RSV-like illness, vaccine effectiveness was 77% in individuals that were immunocompromised, against RSV-associated emergency department encounters.</p><p class="pb-2"></p><p class="pb-2">The findings suggest that RSV vaccination was proved to be 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season. This marked the first RSV season following the release of the approved vaccines, emphasizing their success.</p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. Payne AB, Watts JA, Mitchell PK, et al. Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis. <em>Lancet</em>. 2024;404(10462):1547-1559. doi:10.1016/S0140-6736(24)01738-0</p><p class="pb-2">2. Ferruggia K. RSV Vaccination Could Decrease Hospitalization Among Adults 60 Years and Older. <em>Pharmacy Times</em>. News release. September 6, 2024. Accessed November 13, 2024. https://www.pharmacytimes.com/view/rsv-vaccination-could-decrease-hospitalization-among-adults-60-years-and-older</p><p class="pb-2">3. Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis. Science Direct. News release. October 19, 2024. Accessed November 13, 2024. https://www.sciencedirect.com/science/article/abs/pii/S0140673624017380</p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/exploring-the-differential-effectiveness-of-ics-by-smoking-status-in-copd"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span 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text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/in-room-air-purifiers-could-impact-rsv-incidence-among-older-adults?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9df2ad2c2110dcb557b3509394a82fffa533dc8b-8043x5362.jpg?fit=crop&auto=format" alt="Air purifier | Image credit: Prathankarnpap - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/in-room-air-purifiers-could-impact-rsv-incidence-among-older-adults?utm_source=www.ajmc.com&utm_medium=relatedContent">In-Room Air Purifiers Could Impact RSV Incidence Among Older Adults</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kennedy-ferruggia">Kennedy Ferruggia</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/in-room-air-purifiers-could-impact-rsv-incidence-among-older-adults?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Use of in-room air purifiers with HEPA-14 filters did not result in a significant reduction of acute respiratory infections.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 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wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For the third episode in our special Pride Month series, we speak with Patrick McGovern, CEO of Callen-Lorde since August of 2023 and an outspoken advocate for HIV; lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+); and community health.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/39b5cd25fdc4e2947697c1fbad78955d026f6cc5-6000x4000.jpg?fit=crop&auto=format" alt="RSV risk survey | Image credit: Richelle - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent">Community Pharmacies Hold Key Role in Protecting Older Adults From RSV</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New research reveals gaps in respiratory syncytial virus (RSV) knowledge among older adults and emphasizes the impact community pharmacies can have at improving education and vaccine uptake.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent">A Conversation on the Past, Present, and Future of Public Health: NPHW 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For National Public Health Week this year, we sat down with Kristen Krause, PhD, MPH, instructor in the Department of Urban-Global Public Health and deputy director, Center for Health, Identity, Behavior and Prevention Studies, Rutgers School of Public Health. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ca845f7e6dfc35ab2f006b74744bb6c3a34fff11-5500x4093.jpg?fit=crop&auto=format" alt="FDA approval stamp | Image Credit: Surendra - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">Published: November 15th 2024 | Updated: November 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Revumenib for R/R Acute Leukemia With a KMT2A Translocation</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kristi-rosa">Kristi Rosa</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Revumenib has been approved for relapsed or refractory acute leukemia with KMT2A translocation in patients aged 1 year and older.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/impact-of-rsv-on-hospitalizations-in-us-adults-prior-to-vaccine-introduction?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e8f84cbf1ee43306488ab1b15a39570c4a3242b9-5404x3602.jpg?fit=crop&auto=format" alt="RSV, COVID, Flu vaccines. | Image credit: angellodeco - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/impact-of-rsv-on-hospitalizations-in-us-adults-prior-to-vaccine-introduction?utm_source=www.ajmc.com&utm_medium=relatedContent">Impact of RSV on Hospitalizations in US Adults Prior to Vaccine Introduction</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/impact-of-rsv-on-hospitalizations-in-us-adults-prior-to-vaccine-introduction?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Respiratory syncytial virus (RSV) caused significant hospitalizations and severe outcomes in adults, especially those aged 75 years and older.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/in-room-air-purifiers-could-impact-rsv-incidence-among-older-adults?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9df2ad2c2110dcb557b3509394a82fffa533dc8b-8043x5362.jpg?fit=crop&auto=format" alt="Air purifier | Image credit: Prathankarnpap - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/in-room-air-purifiers-could-impact-rsv-incidence-among-older-adults?utm_source=www.ajmc.com&utm_medium=relatedContent">In-Room Air Purifiers Could Impact RSV Incidence Among Older Adults</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kennedy-ferruggia">Kennedy Ferruggia</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/in-room-air-purifiers-could-impact-rsv-incidence-among-older-adults?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Use of in-room air purifiers with HEPA-14 filters did not result in a significant reduction of acute respiratory infections.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent">Elevating Equitable Health Care for the LGBTQ+ Community</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For the third episode in our special Pride Month series, we speak with Patrick McGovern, CEO of Callen-Lorde since August of 2023 and an outspoken advocate for HIV; lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+); and community health.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/39b5cd25fdc4e2947697c1fbad78955d026f6cc5-6000x4000.jpg?fit=crop&auto=format" alt="RSV risk survey | Image credit: Richelle - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent">Community Pharmacies Hold Key Role in Protecting Older Adults From RSV</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New research reveals gaps in respiratory syncytial virus (RSV) knowledge among older adults and emphasizes the impact community pharmacies can have at improving education and vaccine uptake.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent">A Conversation on the Past, Present, and Future of Public Health: NPHW 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For National Public Health Week this year, we sat down with Kristen Krause, PhD, MPH, instructor in the Department of Urban-Global Public Health and deputy director, Center for Health, Identity, Behavior and Prevention Studies, Rutgers School of Public Health. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ca845f7e6dfc35ab2f006b74744bb6c3a34fff11-5500x4093.jpg?fit=crop&auto=format" alt="FDA approval stamp | Image Credit: Surendra - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">Published: November 15th 2024 | Updated: November 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Revumenib for R/R Acute Leukemia With a KMT2A Translocation</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kristi-rosa">Kristi Rosa</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Revumenib has been approved for relapsed or refractory acute leukemia with KMT2A translocation in patients aged 1 year and older.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/impact-of-rsv-on-hospitalizations-in-us-adults-prior-to-vaccine-introduction?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e8f84cbf1ee43306488ab1b15a39570c4a3242b9-5404x3602.jpg?fit=crop&auto=format" alt="RSV, COVID, Flu vaccines. | Image credit: angellodeco - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/impact-of-rsv-on-hospitalizations-in-us-adults-prior-to-vaccine-introduction?utm_source=www.ajmc.com&utm_medium=relatedContent">Impact of RSV on Hospitalizations in US Adults Prior to Vaccine Introduction</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/impact-of-rsv-on-hospitalizations-in-us-adults-prior-to-vaccine-introduction?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Respiratory syncytial virus (RSV) caused significant hospitalizations and severe outcomes in adults, especially those aged 75 years and older.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":" RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations","datePublished":"2024-11-15T16:59:01.672Z","dateModified":"2024-11-15T17:08:28Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/rsv-vaccine-proven-effective-in-reducing-rsv-related-hospitalizations"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"RSV vaccine effectiveness,RSV hospitalizations prevention,RSV immunization benefits","articleBody":"This article was originally published on Pharmacy Times®. \n\n\n\n\n\nA new study findings published in The Lancet assessed the effectiveness of respiratory syncytial virus (RSV) vaccines against RSV-associated hospitalizations and emergency department encounters among individuals at least 60 years of age. The study was conducted to confirm RSV vaccine effectiveness found in clinical trials against lower respiratory tract disease using real world data.1\n\n\n\nAccording to the CDC, the US experiences up to 160,000 hospitalizations and around 10,000 deaths among older adults due to RSV infection each year. Symptoms typically present like a mild cold but could become more severe among older adults.2\n\n\n\nIn June of 2023, the CDC recommended individuals 60 years and older to receive an RSV vaccine after proving to be effective against RSV-associated lower respiratory tract disease in clinical trials.1,2 The trials displayed that RSVPreF3 (Arexvy; GSK) provided 87.5% efficacy against RSV-associated lower respiratory tract disease and RSVpreF (Abrysvo; Pfizer) provided 84.6% efficacy.3\n\n\n\nHowever, researchers found that there was limited real-world data on the vaccine’s effectiveness. To address the gaps in research from the clinical trials, investigators assessed hospitalizations and emergency department encounters among individuals that reported RSV illness for patients that were at least 60 years of age.1,2\n\n\n\nThe researchers conducted a test-negative design analysis in an electronic health records-based network in 8 US states, which contributed data on inpatient, emergency department, and urgent care encounters among individuals that experienced RSV-associated illness from October 1, 2023, to March 31, 2024. The study authors noted that status of RSV vaccination was confirmed from electronic health record documents, state and city immunization registries, and medical claims.1,3\n\n\n\nAccording to the study authors, vaccine effectiveness was measured by an individual’s immunocompromised status, which compared the odds of vaccination among RSV-positive cases and RSV-negative cases. The estimated effectiveness was adjusted for age, race, ethnicity, sex, calendar day, social vulnerability index, amount of non-respiratory medical conditions, presence of underlying respiratory medical conditions, and geographical region.\n\n\n\nThe results found that, among 28,271 hospitalizations for RSV-like illness in individuals at least 60 years of age and were not immunocompromised, vaccine effectiveness was 80% against RSV-associated hospitalizations and 81% effective against RSV-associated critical illness. Further results found that vaccine effectiveness was 73% among 8435 individuals that were immunocompromised. Additionally, among 36,521 emergency department encounters for RSV-like illness, vaccine effectiveness was 77% in individuals that were immunocompromised, against RSV-associated emergency department encounters.\n\n\n\nThe findings suggest that RSV vaccination was proved to be 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season. This marked the first RSV season following the release of the approved vaccines, emphasizing their success.\n\n\n\nReferences\n\n1. Payne AB, Watts JA, Mitchell PK, et al. Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis. Lancet. 2024;404(10462):1547-1559. doi:10.1016/S0140-6736(24)01738-0\n\n2. Ferruggia K. RSV Vaccination Could Decrease Hospitalization Among Adults 60 Years and Older. Pharmacy Times. News release. September 6, 2024. Accessed November 13, 2024. https://www.pharmacytimes.com/view/rsv-vaccination-could-decrease-hospitalization-among-adults-60-years-and-older\n\n3. Respiratory syncytial virus (RSV) vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA, October, 2023, to March, 2024: a test-negative design analysis. Science Direct. News release. October 19, 2024. Accessed November 13, 2024. https://www.sciencedirect.com/science/article/abs/pii/S0140673624017380","description":"Respiratory syncytial virus (RSV) vaccination is approximately 77% to 81% effective against hospital and emergency department encounters among older adults, study finds. 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The study was conducted to confirm RSV vaccine effectiveness found in clinical trials against lower respiratory tract disease using real world data.","_key":"5f21390bbfbd"},{"marks":["superscript"],"text":"1","_key":"f41fbe9996d1","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"034898ed767f"}],"_type":"block","style":"normal","_key":"855f348fe562","markDefs":[],"upload_doc":null,"uploadAudio":null,"medias":null},{"style":"normal","upload_doc":null,"uploadAudio":null,"medias":null,"_key":"2f1d8525370a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"According to the CDC, the US experiences up to 160,000 hospitalizations and around 10,000 deaths among older adults due to RSV infection each year. Symptoms typically present like a mild cold but could become more severe among older adults.","_key":"0e2bd22cb7150"},{"marks":["superscript"],"text":"2","_key":"d7f311e73d5c","_type":"span"}],"_type":"block"},{"medias":null,"_type":"block","style":"normal","_key":"d8102d0d58c3","markDefs":[],"children":[{"_key":"14840b82fafc","_type":"span","marks":[],"text":""}],"upload_doc":null,"uploadAudio":null},{"upload_doc":null,"uploadAudio":null,"medias":null,"_type":"block","style":"normal","_key":"cf0352f85f51","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In June of 2023, the CDC recommended individuals 60 years and older to receive an RSV vaccine after proving to be effective against RSV-associated lower respiratory tract disease in clinical trials.","_key":"030d1248973f0"},{"_type":"span","marks":["superscript"],"text":"1,2 ","_key":"1306743e347d"},{"marks":[],"text":"The trials displayed that RSVPreF3 (Arexvy; GSK) provided 87.5% efficacy against RSV-associated lower respiratory tract disease and RSVpreF (Abrysvo; Pfizer) provided 84.6% efficacy.","_key":"1b5cdcd8919e","_type":"span"},{"marks":["superscript"],"text":"3","_key":"e426f1472f0c","_type":"span"}]},{"upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"marks":["superscript"],"text":"","_key":"7106e62e6e46","_type":"span"}],"_type":"block","style":"normal","_key":"f6836809cd3e"},{"medias":null,"style":"normal","_key":"09a1d37d5b8c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, researchers found that there was limited real-world data on the vaccine’s effectiveness. To address the gaps in research from the clinical trials, investigators assessed hospitalizations and emergency department encounters among individuals that reported RSV illness for patients that were at least 60 years of age.","_key":"ae8d647d1e650"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"24068db3d56e"}],"_type":"block","upload_doc":null,"uploadAudio":null},{"uploadAudio":null,"medias":null,"_key":"afca1c3157d2","markDefs":[],"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"4c95c598c63d"}],"_type":"block","style":"normal","upload_doc":null},{"medias":null,"_key":"b6085ddae71e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The researchers conducted a test-negative design analysis in an electronic health records-based network in 8 US states, which contributed data on inpatient, emergency department, and urgent care encounters among individuals that experienced RSV-associated illness from October 1, 2023, to March 31, 2024. The study authors noted that status of RSV vaccination was confirmed from electronic health record documents, state and city immunization registries, and medical claims.","_key":"b7c77c5b99d60"},{"_type":"span","marks":["superscript"],"text":"1,3","_key":"3c0c84f5cb32"}],"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null},{"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"b678cc2c35bd"}],"_type":"block","style":"normal","upload_doc":null,"uploadAudio":null,"medias":null,"_key":"77a82e50b97b","markDefs":[]},{"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"_key":"eb6cbc8c267a0","_type":"span","marks":[],"text":"According to the study authors, vaccine effectiveness was measured by an individual’s immunocompromised status, which compared the odds of vaccination among RSV-positive cases and RSV-negative cases. The estimated effectiveness was adjusted for age, race, ethnicity, sex, calendar day, social vulnerability index, amount of non-respiratory medical conditions, presence of underlying respiratory medical conditions, and geographical region."}],"_type":"block","style":"normal","_key":"2927d05882fb","upload_doc":null},{"style":"normal","_key":"af53d9fda4a5","markDefs":[],"children":[{"_key":"550345f0be7d","_type":"span","marks":[],"text":""}],"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null},{"upload_doc":null,"uploadAudio":null,"medias":null,"style":"normal","_key":"4ddc52e6eed6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The results found that, among 28,271 hospitalizations for RSV-like illness in individuals at least 60 years of age and were not immunocompromised, vaccine effectiveness was 80% against RSV-associated hospitalizations and 81% effective against RSV-associated critical illness. Further results found that vaccine effectiveness was 73% among 8435 individuals that were immunocompromised. Additionally, among 36,521 emergency department encounters for RSV-like illness, vaccine effectiveness was 77% in individuals that were immunocompromised, against RSV-associated emergency department encounters.","_key":"b394a1a6aa480"}],"_type":"block"},{"_type":"block","style":"normal","_key":"468d55531325","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"marks":[],"text":"","_key":"1a690fbb6c45","_type":"span"}]},{"style":"normal","_key":"a52c5df73e9a","upload_doc":null,"uploadAudio":null,"medias":null,"markDefs":[],"children":[{"marks":[],"text":"The findings suggest that RSV vaccination was proved to be 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season. 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Accessed November 13, 2024. https://www.sciencedirect.com/science/article/abs/pii/S0140673624017380","_key":"1ec0495159f90"}],"_type":"block","style":"normal","_key":"4236bbb54016","upload_doc":null,"uploadAudio":null,"medias":null}],"ExcludeFromPubMedXML":false,"thumbnail":{"_type":"mainImage","alt":"Blood sample tube for RSV test. | Image credit: JUN LI - stock.adobe.com","asset":{"_ref":"image-d1024943b40e0b87ca36ca1c2a1de913f336757d-7360x4912-jpg","_type":"reference"}},"title":" RSV Vaccine Proven Effective in Reducing RSV-Related Hospitalizations","contentCategory":{"_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","name":"Articles"},"contentGroup":null,"factCheckAuthorMapping":null,"filter":null,"published":"2024-11-15T16:59:01.672Z","_createdAt":"2024-11-15T17:08:18Z","audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/5ad680e9-e6c5-4e17-9de8-0b18bb3fbde8_1731690499434.c1ee2024-589a-4997-bb4c-3a42da41827e.mp3","gptTakeaways":"• RSV vaccines showed 80% effectiveness against hospitalizations and 81% against critical illness in non-immunocompromised individuals aged 60 and older.\n\n• Immunocompromised individuals experienced 73% vaccine effectiveness against hospitalizations and 77% against emergency department encounters.\n\n• The study utilized a test-negative design analysis across eight US states, confirming vaccine efficacy with real-world data.\n\n• The findings underscore the success of RSV vaccines in the 2023-2024 season, following their approval and CDC recommendations.","_rev":"7gdSa6uKISxL9MxpDyPLNl","gptSummary":"A recent study evaluated the effectiveness of RSV vaccines in preventing hospitalizations and emergency department visits among individuals aged 60 and older. The study confirmed the vaccines' efficacy, previously demonstrated in clinical trials, using real-world data. Conducted across eight US states, the research found that RSV vaccines were 80% effective against hospitalizations and 81% effective against critical illness in non-immunocompromised individuals. 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ARIs include influenza, COVID-19, rhinovirus, pneumonia, and RSV. However, RSV specifically imposes a significant threat among older adults as the infection accounts for up to 160,000 hospitalizations and around 10,000 deaths among older adults each year in the US. 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To assess the usage, the researchers conducted a multicenter, double-blind, crossover randomized clinical trial from April 7 to October 26, 2023, in 3 RACFs located in Australia. Individuals included in the study were followed up every 2 weeks throughout the 6-month study period.","_key":"1026ea5016dc0","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_key":"2bb8978f1401","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"4c0702d7b936","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"The study included 135 individuals who were divided into the intervention-first group (n=70) and the control-first group (n=65). 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A recent study in this patient population found that RSV vaccination was 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season.","_key":"81dc5f0e7c830"},{"_type":"span","marks":["superscript"],"text":"2","_key":"ff51678ff454"},{"marks":[],"text":" This marked the first RSV season following the release of the approved vaccines, emphasizing their success.","_key":"739854e4ee09","_type":"span"}],"_type":"block"},{"_type":"block","style":"normal","_key":"a1a99476305f","markDefs":[],"children":[{"text":"","_key":"a3cc09bcf04b0","_type":"span","marks":[]}]},{"style":"normal","_key":"83e1d5c07d84","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the present study, the researchers aimed to evaluate patient knowledge about RSV and to provide patients with information about the virus and the vaccination.","_key":"99be1821783a0"},{"_type":"span","marks":["superscript"],"text":"1","_key":"303a43d706a1"}],"_type":"block"},{"_key":"70071e696e24","markDefs":[],"children":[{"_key":"c8b2b5cee16c0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"style":"normal","_key":"51b5ce20533a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The study was conducted across 4 independent community pharmacy sites from September 12, 2023, to March 11, 2024. Participants 60 years or older were invited to complete a 14-question survey designed to assess their knowledge of RSV and their willingness to receive the RSV vaccine. Survey questions covered demographics, long-term health conditions, knowledge about RSV transmission and prevention, prior education from health care providers, and vaccine acceptance or refusal.","_key":"8fe2e45281670"}],"_type":"block"},{"children":[{"text":"","_key":"820091a2a9bb0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"56b5e5dad1fa","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Participants received an educational handout developed by site pharmacists using CDC guidelines and were offered verbal counseling to support shared decision-making about vaccination. Vaccines were administered on site for participants who consented, regardless of whether they opted for counseling. Data from the anonymous surveys were analyzed using descriptive statistics to evaluate participants’ understanding of RSV, sources of prior knowledge, and factors influencing vaccine uptake or refusal.","_key":"3d769b3c77370"}],"_type":"block","style":"normal","_key":"0f64a8bcc5ce"},{"_key":"88c86c43cf0a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"69a7a03f17a00"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The study included 518 participants, with most aged 71 to 80 years (48%), female (61%), and White (87%) and non-Hispanic (81%). Among them, 61% reported having long-term health conditions, with cardiovascular disease (49%) and lung disease (21%) being the most common. ","_key":"49b1b97d71a00"}],"_type":"block","style":"normal","_key":"fa02a8e952e7"},{"children":[{"_type":"span","marks":[],"text":"","_key":"990062151e9d0"}],"_type":"block","style":"normal","_key":"f7e9df887c50","markDefs":[]},{"children":[{"marks":[],"text":"The primary outcome revealed significant gaps in RSV knowledge, with 78% of participants reporting having never received RSV education from health care providers, although 70% correctly identified its transmission methods. Additionally, 60% of participants understood how to protect themselves, and 58% recognized that prior infection does not confer immunity.","_key":"3a6f631b58d60","_type":"span"}],"_type":"block","style":"normal","_key":"47d6886e9d4c","markDefs":[]},{"markDefs":[],"children":[{"text":"","_key":"fb54382e9ceb0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"f82eb08d1e72"},{"style":"normal","_key":"602845fe9e5b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Regarding vaccination, 63% of participants opted to receive the RSV vaccine on site after completing the survey. Among those who declined, the leading reasons were recent vaccination (57%), lack of perceived necessity (22%), and concerns about adverse effects (11%).","_key":"838a5a98b2000"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"106e84a61c790","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"1d2428838985"},{"style":"normal","_key":"9abc1e915ac5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The study faced several limitations. The survey was only available in English, potentially excluding non–English-speaking individuals and limiting participant diversity. Also, variability in survey administration across the 4 pharmacy sites, managed by different pharmacy residents may have influenced participant understanding, response accuracy, and willingness to participate. The study's small geographic scope limited the generalizability of its results to broader community pharmacy settings, and inconsistencies in pharmacist presence and engagement due to the residents’ limited availability at each site further challenged the uniformity of survey delivery and participant interaction.","_key":"c4a42a3e7b300"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"bbdd8ae1a77d0"}],"_type":"block","style":"normal","_key":"347724a9cb11","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Despite these limitations, the researchers believe the study findings provide valuable insights on the knowledge and attitudes toward RSV and its vaccine in an older adult population.","_key":"e64624eea1b40"}],"_type":"block","style":"normal","_key":"6984977866b1"},{"style":"normal","_key":"ffd3b1d2a6dc","markDefs":[],"children":[{"_key":"80c9cea6363d0","_type":"span","marks":[],"text":""}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“The willingness to receive the RSV vaccine was relatively high among participants who received verbal counseling and education from a pharmacist along with the educational handout, although vaccine hesitancy remains a barrier,” wrote the researchers. “This study emphasizes the critical role of a community pharmacist in health care delivery and the need for enhanced educational efforts to support vaccination programs and shared clinical health care decision-making.”","_key":"eb0ebfab49f60"}],"_type":"block","style":"normal","_key":"70267fc737b5"},{"_type":"block","style":"normal","_key":"900efd58f031","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"482e867c6e6a0"}]},{"_key":"6a0f54d7ecd0","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"97d1035d24470"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"dc007556e5cb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"1. 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The phase 1/2 AUGMENT-101 study demonstrated a 21.2% complete remission rate with a median duration of 6.4 months. Additionally, 14% of patients achieved independence from red blood cell and platelet transfusions. Common adverse effects included hemorrhage, nausea, increased phosphate levels, and musculoskeletal pain. The approval marks a significant advancement in targeted therapy for this specific leukemia subset.","authors":[{"displayName":"Kristi Rosa","url":"kristi-rosa"}],"_type":"article","body":[{"_type":"block","style":"normal","_key":"75a54d3e9100","markDefs":[{"nofollow":false,"blank":true,"_type":"link","href":"https://www.onclive.com/view/fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation","_key":"6fc46bcc034d"}],"children":[{"_key":"e7a4b0e240c5","_type":"span","marks":["em"],"text":"This article originally "},{"_type":"span","marks":["6fc46bcc034d","em"],"text":"appeared on ","_key":"e1d44958d5bf"},{"marks":["6fc46bcc034d"],"text":"OncLive","_key":"c10873644e3d","_type":"span"},{"_type":"span","marks":["6fc46bcc034d","em","superscript"],"text":"®","_key":"7c1005484389"},{"_key":"ab19c0597360","_type":"span","marks":["em"],"text":". "}]},{"_key":"7ee0b2c1ded7","alignment":"right","widthP":30,"alt":"FDA approval with stamp. | Image Credit: Surendra - stock.adobe.com","disableLightBox":true,"imgcaption":[{"_type":"block","style":"normal","_key":"a067baf383a9","markDefs":[],"children":[{"marks":[],"text":"The AUGMENT-101 study showed a 21.2% complete remission rate with a median duration of 6.4 months.","_key":"fc66d38024f00","_type":"span"}]},{"children":[{"text":"Image Credit: Surendra - stock.adobe.com","_key":"7383d15cd9ce0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"fca696b1ae87","markDefs":[]}],"asset":{"_ref":"image-ca845f7e6dfc35ab2f006b74744bb6c3a34fff11-5500x4093-jpg","_type":"reference"},"disableTextWrap":false,"_type":"figure"},{"children":[{"_type":"span","marks":[],"text":"The FDA has approved revumenib (Revuforj) for the treatment of adult and pediatric patients aged 1 year and older with relapsed or refractory acute leukemia and a ","_key":"64a870eb73c20"},{"text":"KMT2A","_key":"64a870eb73c21","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":" translocation.","_key":"64a870eb73c22"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"481cf1ebac26"}],"_type":"block","style":"normal","_key":"b1b9e2f40530","markDefs":[]},{"_key":"88fafc22b989","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Data from the phase 1/2 AUGMENT-101 study (SNDX-5613-0700; NCT04065399) showed that the menin inhibitor (n = 104) led to a complete remission (CR) plus CR with partial hematologic recovery (CRh; CR+CRh) rate of 21.2% (95% CI, 13.8%-30.3%) with a median duration of CR+CRh of 6.4 months (95% CI, 2.7-not estimable [NE]). In the patients who achieved a CR or CRh with revumenib (n = 22), the median time to response was 1.9 months (range, 0.9-5.6).","_key":"5fbd664ed9790"}],"_type":"block","style":"normal"},{"_key":"ea2a79ce7b2f","markDefs":[],"children":[{"_key":"58283f709cee0","_type":"span","marks":[],"text":"Moreover, 14% of 83 patients who were dependent on red blood cell (RBC) and platelet transfusions at baseline achieved independence during any 56-day post-baseline period, and 48% of 21 patients who were independent at baseline remained independent."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"The FDA approval of the first menin inhibitor is a major breakthrough for patients with R/R acute leukemia with a KMT2A translocation, a genetic alteration associated with a very poor prognosis,\" Ghayas C. Issa, MD, associate professor of leukemia at The University of Texas MD Anderson Cancer Center, stated in a news release.","_key":"7f590bcc55210"},{"text":"3","_key":"03a636a59bd9","_type":"span","marks":["superscript"]},{"_type":"span","marks":[],"text":" \"The significant clinical benefit and robust efficacy seen with Revuforj represents a substantial improvement over what has been historically observed in these patients with previously available therapies and has the potential to be an important new treatment option for patients.\"","_key":"3e163ccac259"}],"_type":"block","style":"normal","_key":"01303d417a94"},{"_key":"caf56161dc85","markDefs":[],"children":[{"text":"About AUGMENT-101: Eligibility, Treatment, Objectives","_key":"c5baa97694080","_type":"span","marks":[]}],"_type":"block","style":"h2"},{"_type":"block","style":"normal","_key":"4be4a82a9b71","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The single-arm cohort of an open-label, multicenter trial enrolled adult and pediatric patients at least 30 days old who had relapsed or refractory acute leukemia harboring a ","_key":"60efbe4b7b400"},{"_key":"60efbe4b7b401","_type":"span","marks":["em"],"text":"KMT2A"},{"marks":[],"text":" translocation.","_key":"60efbe4b7b402","_type":"span"},{"_type":"span","marks":["superscript"],"text":"2","_key":"3fc3c488e08a"},{"_key":"1ce489011e54","_type":"span","marks":[],"text":" To be eligible, patients needed to have a corrected QT interval of less than 450 milliseconds. Those with an 11q23 partial tandem duplication were not permitted."}]},{"_key":"d0ab137320ee","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Revumenib was administered at a dose that was approximately equivalent to 160 mg in adults orally twice daily with a strong CYP3A4 inhibitor. Treatment continued until progressive disease, intolerable toxicity, failure to achieve a morphological leukemia-free state by 4 cycles of treatment, or hematopoietic stem cell transplantation.","_key":"d01dd4e423a70"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"1e5889fb6f65","markDefs":[],"children":[{"_key":"86a8313307100","_type":"span","marks":[],"text":"The primary end point was CR+CRh rate."}]},{"style":"h2","_key":"eccf2043bd64","markDefs":[],"children":[{"text":"Diving Into Demographic and Disease Characteristics","_key":"94a09963addd0","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"4c9d30a6a9d4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the cohort (n = 114) median patient age was 37 years (range, 1-79), with 24% younger than 17 years. More than half of the patients (64%) were female and most were White (72%) and not Hispanic or Latino (73%). Eighty-three percent of patients had AML, 15% had acute lymphoblastic leukemia, and 2% had mixed phenotype acute leukemia.","_key":"31ccd06ff1bd0"}]},{"children":[{"_type":"span","marks":[],"text":"Moreover, 22%, 19%, 10%, 10%, 7%, 3%, 2%, 2%, and 1% of patients had t(9;11), t(11;19), t(6;11), t(10;11), t(4;11), t(1;11), t(11;17), t(11;22), and t(11;16), respectively. Twenty-five percent of patients had an unknown ","_key":"403fe5978d4d0"},{"_key":"403fe5978d4d1","_type":"span","marks":["em"],"text":"KMT2A"},{"_type":"span","marks":[],"text":" fusion partner. More than half of patients had relapsed/refractory disease (59%); 21% and 20% of patients had primary refractory or untreated relapsed disease.","_key":"403fe5978d4d2"}],"_type":"block","style":"normal","_key":"2b316cbc320e","markDefs":[]},{"children":[{"marks":[],"text":"The median number of previous regimens received was 2, with a range of 1 to 11 regimens. Forty-four percent of patients underwent prior stem cell transplantation. Fifty-three percent of patients had 1 prior relapse, 19% had 2 prior relapses, and 7% had 3 or more prior relapses.","_key":"185d6e803ef30","_type":"span"}],"_type":"block","style":"normal","_key":"54938d2c14af","markDefs":[]},{"_key":"74ce72833a61","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Additional Efficacy Data","_key":"68f131c663710"}],"_type":"block","style":"h2"},{"_key":"dc1a1e0ed8f0","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The median follow-up was 5.73 months (range, 0.3-28.9). Additional findings showed that 12.5% (95% CI, 6.8%-20.4%) of patients achieved a CR and the median duration of CR was 4.3 months (95% CI, 1.0-NE). The CRh rate was 8.7% (95% CI, 4.0%-15.8%) and the median duration of CRh was 6.4 months (95% CI, 1.9-NE).","_key":"cdb806484d0c0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"c6611d7571c6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Subgroup analysis revealed that CR+CRh was achieved in 21%, 19%, and 50% of patients with AML (n = 18/86), ALL (n = 3/16), and MPAL (n = 1/2), respectively.","_key":"6e0c2b23b6950"}],"_type":"block"},{"_type":"block","style":"h2","_key":"4d84d2fec6e5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Shedding Light on Safety","_key":"1d36479124190"}]},{"_key":"cf2f62aae15b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The safety of revumenib was examined in 104 adult patients and 31 pediatric patients with relapsed or refractory acute leukemia and a ","_key":"ff02a9a9125c0"},{"_key":"ff02a9a9125c1","_type":"span","marks":["em"],"text":"KMT2A"},{"_key":"ff02a9a9125c2","_type":"span","marks":[],"text":" translocation. The median duration of exposure was 2.3 months (range, \u003c1-23)."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The most common toxicities experienced by at least 20% of patients included hemorrhage (all grade, 53%; grade 3/4, 9%), nausea (51%; 4%), musculoskeletal pain (42%; 6%), infection (41%; 29%), febrile neutropenia (35%; 33%), bacterial infection (31%; 20%), diarrhea (30%; 4%), differentiation syndrome (29%; 13%), prolonged electrocardiogram QT (29%; 12%), decreased appetite (24%; 8%), constipation (23%; 1%) viral infection (23%; 4%), edema (23%; 1%), fatigue (22%; 5%), thrombosis (10%; 5%), and leukocytosis (8%; 5%).","_key":"d9ec4c2503750"}],"_type":"block","style":"normal","_key":"fe84a54a4fb3"},{"_key":"aebd2809d7c6","markDefs":[],"children":[{"_key":"f4c350ace4860","_type":"span","marks":[],"text":"Forty-two percent of patients experienced adverse effects (AEs) that required dose interruptions and 10% experienced AEs that led to dose reductions. Serious AEs were reported in 73% of patients and 3% experienced AEs that proved fatal (differentiation syndrome, n = 2; hemorrhage, n = 1); sudden death, n = 1)."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"References","_key":"1c8569c3b9a90"}],"_type":"block","style":"h3","_key":"71f58c816a01"},{"_key":"7a58591a5c07","listItem":"number","markDefs":[],"children":[{"_key":"12a1baf2157e0","_type":"span","marks":[],"text":"FDA approves revumenib for relapsed or refractory acute leukemia with a KMT2A translocation. FDA. November 15, 2024. Accessed November 15, 2024. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-revumenib-relapsed-or-refractory-acute-leukemia-kmt2a-translocation"}],"level":1,"_type":"block","style":"normal"},{"listItem":"number","markDefs":[],"children":[{"marks":[],"text":"Revuforj. Prescribing information. Syndax Pharmaceuticals, Inc.; 2024. Accessed November 15, 2024. https://cms.syndax.com/wp-content/uploads/Revuforj-full-prescribing-info.pdf","_key":"73a81c83a92d0","_type":"span"}],"level":1,"_type":"block","style":"normal","_key":"98572eb5a147"},{"level":1,"_type":"block","style":"normal","_key":"911a1b9553e9","listItem":"number","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Syndax announces FDA approval of Revuforj (revumenib), the first and only menin inhibitor to treat adult and pediatric patients with relapsed or refractory acute leukemia with a KMT2A translocation. News release. Syndax Pharmaceuticals, Inc. November 15. 2024. Accessed November 15, 2024. https://ir.syndax.com/news-releases/news-release-details/syndax-announces-fda-approval-revuforjr-revumenib-first-and-only","_key":"c803a86eeb150"}]}],"gptTakeaways":"• Revumenib is approved for relapsed or refractory acute leukemia with KMT2A translocation in patients aged 1 year and older.\n\n• The AUGMENT-101 study showed a 21.2% complete remission rate with a median duration of 6.4 months.\n\n• Fourteen percent of patients achieved independence from red blood cell and platelet transfusions.\n\n• Common adverse effects included hemorrhage, nausea, increased phosphate levels, and musculoskeletal pain.","url":"fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation","thumbnail":{"_type":"mainImage","alt":"FDA approval stamp | Image Credit: Surendra - stock.adobe.com","asset":{"_ref":"image-ca845f7e6dfc35ab2f006b74744bb6c3a34fff11-5500x4093-jpg","_type":"reference"}},"articleType":"News","is_visible":true,"_rev":"N06nnxz6bPVwWf6YI33uh0","published":"2024-11-15T21:43:39.620Z","_createdAt":"2024-11-15T21:50:24Z","summary":"Revumenib has been approved for relapsed or refractory acute leukemia with KMT2A translocation in patients aged 1 year and older.","audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/a3469edb-7714-4fb4-9154-5393729c8d29_1731707425562.463f97cc-62c5-42c3-a72f-e9fa65dbdcd8.mp3","ExcludeFromPubMedXML":false,"drugMentions":"{\n \"drug_mentions\": [\"revumenib\"]\n}","factCheckAuthorMapping":null,"_id":"a3469edb-7714-4fb4-9154-5393729c8d29","_updatedAt":"2024-11-19T14:50:19Z","targeting":{"content_placement":["news","compendium/all","fda-approvals","topic/clinical"],"document_url":["fda-approves-revumenib-for-r-r-acute-leukemia-with-a-kmt2a-translocation"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"FDA Accepts Resubmitted NDA for Ataluren in Nonsense Duchenne Muscular Dystrophy","url":{"current":"fda-accepts-resubmitted-nda-for-ataluren-in-nonsense-duchenne-muscular-dystrophy","_type":"slug"},"thumbnail":{"alt":"FDA website | Image Credit: © Postmodern Studio - 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Eligible participants included nonpregnant adults 18 years or older who had a positive RSV test result during hospitalization or within 14 days prior.","_key":"a82aa5106f10"}],"_type":"block","style":"normal"},{"_key":"16380ac88e0e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5ca6fa7a4df80"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The primary outcome of the study was the burden of RSV in US adults, measured by the rates of RSV-associated hospitalizations, ICU admissions, and in-hospital deaths.","_key":"fe03abd05d190"}],"_type":"block","style":"normal","_key":"2e6b5e8f1f1d"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b7577e6bf7380"}],"_type":"block","style":"normal","_key":"bc7454e06822"},{"children":[{"_type":"span","marks":[],"text":"Between the 2016-2017 and 2022-2023 RSV seasons, the study identified a total of 16,575 laboratory-confirmed RSV-associated hospitalizations, with reverse transcription polymerase chain reaction (RT-PCR) being the primary diagnostic test (98.7%). Additionally, a significant majority of patients (62.6%) were 65 or older.","_key":"a385dd90245c0"}],"_type":"block","style":"normal","_key":"a2c3e613dede","markDefs":[]},{"children":[{"marks":[],"text":"","_key":"4ae69ff4602d0","_type":"span"}],"_type":"block","style":"normal","_key":"399d55732546","markDefs":[]},{"_type":"block","style":"normal","_key":"31aee9c247d7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Hospitalization rates peaked in January each year, with notable disruptions during the COVID-19 pandemic. ICU admissions occurred in 19.1% of cases, and 4.3% of patients died in the hospital, with the highest mortality rate (5.8%) observed in adults 75 years or older.","_key":"2c16c00695a00"}]},{"_type":"block","style":"normal","_key":"45bcf66ece5f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3da1496107180"}]},{"children":[{"text":"Testing practices improved over time, increasing from 30.4% of hospitalized adults in 2016-2017 to over 60% in 2022-2023. The unadjusted hospitalization rate ranged from 8.8 to 21.2 per 100,000 adults, while adjusted rates varied significantly by age, peaking among adults 75 years or older. The estimated number of annual RSV-associated hospitalizations ranged from 123,000 in 2016-2017 to 193,000 in 2017-2018, with ICU admissions and in-hospital deaths also showing substantial burden.","_key":"a3a08d3e0da40","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"76d38df24b31","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"aa99ac5644d60","_type":"span"}],"_type":"block","style":"normal","_key":"0d4034241072"},{"_type":"block","style":"normal","_key":"6e41393bf688","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Older adults, especially those 75 years and older, accounted for most severe outcomes, representing 45.6% of hospitalizations, 38.6% of ICU admissions, and 58.7% of in-hospital deaths.","_key":"ff0b65ca1f8b0"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ce48f644c16d0"}],"_type":"block","style":"normal","_key":"7c2a6062c0c6"},{"_type":"block","style":"normal","_key":"cc12194e592e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, the researchers acknowledged several limitations. First, RSV testing was based on clinicians' discretion, potentially leading to an underestimation of the true RSV burden. Although adjustments were made for testing practices and test sensitivity, the underlying assumptions may be incorrect. Therefore, the burden estimates could be biased. Additionally, the analysis did not include nonrespiratory complications of RSV or assess primary reasons for hospitalization. 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