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flex flex-col overflow-hidden relative bg-white text-center"><div class="jsx-609564708 relative w-full shadow-md shadow-grey-800 aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="object-cover" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa1f3330fe4848b899f70486f31b7c8a73df8f3f8-1280x720.jpg%2FSilverbergTN3.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-609564708 content-wrap"><span class="jsx-609564708 py-3 text-sm text-gray-500 text-left"><i class="jsx-609564708">January 4th 2024</i></span><div class="jsx-609564708 w-full h-fit mb-4"><p class="jsx-609564708 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Dr Jonathan Silverberg Lists Which Patients With AD Benefit Most From JAK Inhibitors</p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-ad-identified-as-potential-risk-factor-for-headache-disorder"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/20889be9c8c12dc41a85d9e54ca3d9942207c31d-5616x3744.jpg?fit=crop&auto=format" alt="Female patient with headache pain | Image Credit: Artem Furman - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-ad-identified-as-potential-risk-factor-for-headache-disorder">Study: AD Identified as Potential Risk Factor for Headache Disorder</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-ad-identified-as-potential-risk-factor-for-headache-disorder"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with atopic dermatitis (AD) may have an increased risk of headache disorder and migraines.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/children-born-to-mothers-with-stress-mental-health-conditions-during-pregnancy-at-higher-ad-risk"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/fbab2b19d55aa46e81db8af632893b82be2bde47-6000x4000.jpg?fit=crop&auto=format" alt="sleeping infant holding mother's finger | Image Credit: Bostan Natalia - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 2nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/children-born-to-mothers-with-stress-mental-health-conditions-during-pregnancy-at-higher-ad-risk">Children Born to Mothers With Stress, Mental Health Conditions During Pregnancy at Higher AD Risk</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/children-born-to-mothers-with-stress-mental-health-conditions-during-pregnancy-at-higher-ad-risk"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A meta-analysis found significant associations between maternal stress, anxiety, depression, and adverse life events during pregnancy with increased atopic dermatitis (AD) risk in offspring.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/children-with-ad-neurodevelopmental-comorbidities-at-greater-odds-of-learning-memory-difficulties"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/73291959f906333046db4310a9d050f6e67ed450-6240x3801.jpg?fit=crop&auto=format" alt="child scratching atopic dermatitis | Image Credit: Марина Терехова - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/children-with-ad-neurodevelopmental-comorbidities-at-greater-odds-of-learning-memory-difficulties">Children With AD, Neurodevelopmental Comorbidities at Greater Odds of Learning, Memory Difficulties</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/children-with-ad-neurodevelopmental-comorbidities-at-greater-odds-of-learning-memory-difficulties"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Children with atopic dermatitis (AD) face higher chances of learning and memory difficulties, particularly when they have neurodevelopmental comorbidities, like attention-deficit/hyperactivity disorder.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-patients-with-ad-limited-health-literacy-face-impaired-quality-of-life"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/134521fd8c460ed94dcc712d4c0a88ab6fa97963-3301x2395.jpg?fit=crop&auto=format" alt="Quality of life | Image Credit: gustavofrazao - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-patients-with-ad-limited-health-literacy-face-impaired-quality-of-life">Study: Patients With AD, Limited Health Literacy Face Impaired Quality of Life</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-patients-with-ad-limited-health-literacy-face-impaired-quality-of-life"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A considerable number of patients with atopic dermatitis (AD) and limited health literacy, especially older individuals, experienced impaired health-related quality of life.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dupilumab-considered-safe-effective-for-ad-in-real-life-settings"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a30f8534226e504e1f369b1f64da0261d00e909f-6240x4160.jpg?fit=crop&auto=format" alt="Adult scratching atopic dermatitis on arm | Image Credit: ltyuan - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 4th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dupilumab-considered-safe-effective-for-ad-in-real-life-settings">Dupilumab Considered Safe, Effective for AD in Real-Life Settings</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dupilumab-considered-safe-effective-for-ad-in-real-life-settings"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This study enhances current understandings of dupilumab use in patients with atopic dermatitis (AD) by showing its real-world effectiveness and safety.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/upadacitinib-effective-in-treating-patients-with-moderate-to-severe-ad-study-says"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f234603bd7f97415e1893931f8dbaf82d713242-7952x5304.jpg?fit=crop&auto=format" alt="Upadacitinib | Image Credit: luchschenF - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/upadacitinib-effective-in-treating-patients-with-moderate-to-severe-ad-study-says">Upadacitinib Effective in Treating Patients With Moderate to Severe AD, Study Says</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/upadacitinib-effective-in-treating-patients-with-moderate-to-severe-ad-study-says"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Adult patients with moderate to severe atopic dermatitis (AD) had a 1-year and 1.5-year upadacitinib drug survival of 91.5% and 80.2%, respectively.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/telemedicine-considered-equivalent-to-in-person-care-for-ad-follow-up"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/aa55cba013e542363db5e3021a7d049b005c0d44-7360x4912.jpg?fit=crop&auto=format" alt="female patient speaking with physician on video call | Image Credit: rh2010 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 8th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/telemedicine-considered-equivalent-to-in-person-care-for-ad-follow-up">Telemedicine Considered Equivalent to In-Person Care for AD Follow-Up</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/telemedicine-considered-equivalent-to-in-person-care-for-ad-follow-up"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This systemic review determined telemedicine to be as effective as in-person appointments for the follow-up of patients with atopic dermatitis (AD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-tralokinumab-caused-more-frequent-injection-site-reactions-than-dupilumab-in-patients-with-ad"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cfde0828443f149997a7a2086456ee374f7a9d34-4141x2761.jpg?fit=crop&auto=format" alt="Injection site reaction | Image Credit: Irina Schmidt - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 7th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-tralokinumab-caused-more-frequent-injection-site-reactions-than-dupilumab-in-patients-with-ad">Study: Tralokinumab Shows More Frequent Injection Site Reactions Than Dupilumab in Patients With AD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-tralokinumab-caused-more-frequent-injection-site-reactions-than-dupilumab-in-patients-with-ad"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Although injection site reactions were common occurrences in both the tralokinumab and dupilumab groups, tralokinumab caused ISRs more frequently.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/combination-dupilumab-topical-corticosteroids-treatment-demonstrated-efficacy-in-children-with-ad"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/04bfbda193785ce69eaabd6ae5b01bb50ead4248-5351x3567.jpg?fit=crop&auto=format" alt="Child with atopic dermatitis (AD) | Image Credit: Юля Шевцова - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 2nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/combination-dupilumab-topical-corticosteroids-treatment-demonstrated-efficacy-in-children-with-ad">Combination Dupilumab, Topical Corticosteroids Treatment Demonstrated Efficacy in Children With AD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/combination-dupilumab-topical-corticosteroids-treatment-demonstrated-efficacy-in-children-with-ad"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Dupilumab and topical corticosteroids can be used to treat symptoms in children with atopic dermatitis (AD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/climatic-hazards-directly-impact-patients-with-ad-review-says"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b41a82faddae95bdd8d4209b107c61a707625a21-7768x4000.jpg?fit=crop&auto=format" alt="climate change | Image Credit: jozsitoeroe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/climatic-hazards-directly-impact-patients-with-ad-review-says">Climatic Hazards Directly Impact Patients With AD, Review Says</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/climatic-hazards-directly-impact-patients-with-ad-review-says"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Global warming, wildfires, precipitation, floods, and storms impact patients with atopic dermatitis (AD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ad-patients-caregivers-prioritize-symptom-control-minimizing-adverse-effects-during-treatment"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/851684487922df1e6e0de47826946729a90c0d4a-5951x3967.jpg?fit=crop&auto=format" alt="Atopic dermatitis treatment | Image Credit: Ladanifer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ad-patients-caregivers-prioritize-symptom-control-minimizing-adverse-effects-during-treatment">AD Patients, Caregivers Prioritize Symptom Control, Minimizing Adverse Effects During Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ad-patients-caregivers-prioritize-symptom-control-minimizing-adverse-effects-during-treatment"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The researchers suggested that physicians consider age-relevant atopic dermatitis (AD) treatment preferences in discussions with patients and caregivers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/weekend-catch-up-sleep-prevents-suicidal-ideation-in-adolescent-patients-with-ad-study-says"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/66d9a98c5a3fc8dcd9ac21c82ed26ff73451d6a7-5760x3840.jpg?fit=crop&auto=format" alt="Adolescent sleeping | Image Credit: digitalskillet1 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/weekend-catch-up-sleep-prevents-suicidal-ideation-in-adolescent-patients-with-ad-study-says">Weekend Catch-Up Sleep Prevents Suicidal Ideation in Adolescent Patients With AD, Study Says </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/weekend-catch-up-sleep-prevents-suicidal-ideation-in-adolescent-patients-with-ad-study-says"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This study suggests that adolescents with atopic dermatitis (AD) sleep less, have greater sleep dissatisfaction, and longer weekend catch-up sleep (WCUS) than those without AD.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-andy-blauvelt-recommends-new-novel-ad-treatments"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d0b6ca281cb1bd4dd15d50f8f1378632ed396b40-2880x1537.png?fit=crop&auto=format" alt="dr andy blauvelt" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 2nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-andy-blauvelt-recommends-new-novel-ad-treatments">Dr Andy Blauvelt Recommends New Novel AD Treatments</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-andy-blauvelt-recommends-new-novel-ad-treatments"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Andy Blauvelt, MD, MBA, president of Oregon Medical Research Center, recommends new novel topical therapies over topical steroids for patients with atopic dermatitis (AD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-elaine-siegfried-describes-how-aad-guideline-update-impacts-ad-treatment"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b156aa69b8e4268b42d4b096d87eaadd7e027450-2665x1531.png?fit=crop&auto=format" alt="dr elaine siegfried" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 1st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-elaine-siegfried-describes-how-aad-guideline-update-impacts-ad-treatment">Dr Elaine Siegfried Describes How AAD Guideline Update Impacts AD Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-elaine-siegfried-describes-how-aad-guideline-update-impacts-ad-treatment"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Elaine Siegfried, MD, of Saint Louis University School of Medicine, discusses how the recent guideline update by the American Academy of Dermatology (AAD) affects dermatologists' atopic dermatitis (AD) treatment decisions.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-ad-content-of-2023"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6a45cb4b9431c2845646a6ca5a058dddda29d27e-1020x520.png?fit=crop&auto=format" alt="top 5 AD articles " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 28th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-ad-content-of-2023">Top 5 Most-Read AD Content of 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/top-5-most-read-ad-content-of-2023"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This year’s most-read articles on atopic dermatitis (AD) explored different treatment and education methods.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/exploring-the-relationship-between-ad-psychological-stress-sleep-disturbances-salivary-biomarkers"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1c55d84e2c4048da3c25f2cc3ed1e24e1c5c8ac7-4256x2832.jpg?fit=crop&auto=format" alt="atopic dermatitis" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 20th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/exploring-the-relationship-between-ad-psychological-stress-sleep-disturbances-salivary-biomarkers">Exploring the Relationship Between AD, Psychological Stress, Sleep Disturbances, Salivary Biomarkers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/lauren-buchanan-ma-managing-editor">Lauren Buchanan, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/exploring-the-relationship-between-ad-psychological-stress-sleep-disturbances-salivary-biomarkers"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Understanding these relationships is crucial for developing effective clinical management strategies for patients with AD, according to a recent literature review.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-rad-2023"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/263c6d1bcbe64c6d016036ee243011fbbbec2c05-3187x1625.png?fit=crop&auto=format" alt="ICYMI: Highlights From RAD 2023" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 17th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-rad-2023">ICYMI: Highlights From RAD 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-rad-2023"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Our top coverage from this year’s Revolutionizing Atopic Dermatitis (RAD) conference highlighted the evolving therapy landscape for patients with AD. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-elaine-siegfried-discusses-using-biologics-to-treat-ad"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b156aa69b8e4268b42d4b096d87eaadd7e027450-2665x1531.png?fit=crop&auto=format" alt="dr elaine siegfried" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 12th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-elaine-siegfried-discusses-using-biologics-to-treat-ad">Dr Elaine Siegfried Discusses Using Biologics to Treat AD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-elaine-siegfried-discusses-using-biologics-to-treat-ad"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Elaine Siegfried, MD, of Saint Louis University School of Medicine discusses the use of biologics to treat atopic dermatitis (AD) and how they differ from other treatments.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/worsening-severity-of-ad-in-children-associated-with-increased-comorbidity-onset-risk"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/618023f2e60041d285c98320303dd0edbc2b23eb-5760x3840.jpg?fit=crop&auto=format" alt="child with AD" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 10th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/worsening-severity-of-ad-in-children-associated-with-increased-comorbidity-onset-risk">Worsening Severity of AD in Children Associated With Increased Comorbidity Onset Risk</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/joshua-fitch">Joshua Fitch</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/worsening-severity-of-ad-in-children-associated-with-increased-comorbidity-onset-risk"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Of patients in the atopic dermatitis (AD) cohort, 36.6% developed at least 1 comorbidity amid follow-up compared to 28.5% in the non-AD reference cohort.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/most-patients-with-ad-satisfied-with-baricitinib-treatment-study-says"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/690165cc12a8154f8ce3951a41de04f986e84123-5341x3560.jpg?fit=crop&auto=format" alt="Baricitinib" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 5th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/most-patients-with-ad-satisfied-with-baricitinib-treatment-study-says">Most Patients With AD Satisfied With Baricitinib Treatment, Study Says</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/most-patients-with-ad-satisfied-with-baricitinib-treatment-study-says"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Based on the Likert scale, most patients with atopic dermatitis (AD) using baricitinib reported being either “satisfied” (76%) or “very satisfied” (18%).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/mental-health-concerns-prevalent-in-patients-with-ad-poster-says"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e926faf39a0b61879b4fd879bf5ce1ff514ca867-8305x5304.jpg?fit=crop&auto=format" alt="patient with mental health issues" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mental-health-concerns-prevalent-in-patients-with-ad-poster-says">Mental Health Concerns Prevalent in Patients With AD, Poster Says</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/heidi-anne-duerr-mph">Heidi Anne Duerr, MPH</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mental-health-concerns-prevalent-in-patients-with-ad-poster-says"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A new study presented at this year’s American College of Allergy, Asthma and Immunology Annual Scientific Meeting highlights the need for mental health support in patients with atopic dermatitis (AD).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/aad-updates-guidelines-for-ad-treatment-using-phototherapy-systemic-therapies"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f4bb8db60db72afc836851f5efacf1358e4e0649-6497x4331.jpg?fit=crop&auto=format" alt="doctor speaking with patient" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/aad-updates-guidelines-for-ad-treatment-using-phototherapy-systemic-therapies">AAD Updates Guidelines for AD Treatment Using Phototherapy, Systemic Therapies</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/aad-updates-guidelines-for-ad-treatment-using-phototherapy-systemic-therapies"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">These new atopic dermatitis (AD) treatment guidelines from the American Academy of Dermatology (AAD) update their 2014 recommendations for the management of AD with phototherapy and systemic therapies.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-proposes-new-ad-treatment-standards"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f70b3c100a1f2229ee8053058243a4d51720194f-2865x1615.png?fit=crop&auto=format" alt="dr april armstrong" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 14th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-proposes-new-ad-treatment-standards">Dr April Armstrong Proposes New AD Treatment Standards</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hayden-e-klein">Hayden E. Klein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-proposes-new-ad-treatment-standards"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">With the recent development of various new treatments, April Armstrong, MD, MPH, discusses the new standards she and other dermatologists hope to set for treating patients with atopic dermatitis (AD). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/long-term-safety-of-dupilumab-in-adults-with-moderate-to-severe-atopic-dermatitis"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/77c2c84d9048d107cc226b88c416df6c7d4ebfad-6240x4160.jpg?fit=crop&auto=format" alt="adult patient with atopic dermatitis (AD)" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 9th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/long-term-safety-of-dupilumab-in-adults-with-moderate-to-severe-atopic-dermatitis">Long-Term Safety of Dupilumab in Adults With Moderate to Severe Atopic Dermatitis</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/lauren-buchanan-ma-managing-editor">Lauren Buchanan, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/long-term-safety-of-dupilumab-in-adults-with-moderate-to-severe-atopic-dermatitis"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The results from this 5-year, open-label extension trial affirm the safety of dupilumab in adults with moderate to severe AD.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-peter-lio-describes-the-ad-treatment-toolkit"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/33d6ae51e99089b0a522cb66b24dc01f917b0230-2880x1613.png?fit=crop&auto=format" alt="dr peter lio" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 6th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-peter-lio-describes-the-ad-treatment-toolkit">Dr Peter Lio Describes the AD Treatment Toolbox</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hayden-e-klein">Hayden E. Klein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-peter-lio-describes-the-ad-treatment-toolkit"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Peter A. Lio, MD, clinical assistant professor of dermatology and pediatrics at Northwestern University's Feinberg School of Medicine, describes different methods dermatologists can use to treat atopic dermatitis (AD). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/middle-aged-older-adults-with-ad-at-increased-risk-of-cognitive-dysfunction"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/40872453de9916931451a20765bdfb9e5d8efc2a-6720x4480.jpg?fit=crop&auto=format" alt="middle aged patient with atopic dermatitis" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/middle-aged-older-adults-with-ad-at-increased-risk-of-cognitive-dysfunction">Middle-Aged, Older Adults With AD at Increased Risk of Cognitive Dysfunction</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/middle-aged-older-adults-with-ad-at-increased-risk-of-cognitive-dysfunction"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Because of their study's findings, the researchers urged clinicians to screen patients with atopic dermatitis (AD) for cognitive dysfunction.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-how-recent-biologics-advancements-improved-ad-treatment"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f70b3c100a1f2229ee8053058243a4d51720194f-2865x1615.png?fit=crop&auto=format" alt="dr april armstrong" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 30th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-how-recent-biologics-advancements-improved-ad-treatment">Dr April Armstrong: How Recent Biologics Advancements Improved AD Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hayden-e-klein">Hayden E. Klein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-how-recent-biologics-advancements-improved-ad-treatment"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">April Armstrong, MD, MPH, of University of California, Los Angeles, discussed how recent biologics advancements improved moderate-to-severe atopic dermatitis (AD) treatment. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/more-than-half-of-adults-with-moderate-to-severe-ad-report-conditions-that-may-influence-selection-of-jak-inhibitors"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6d34edecb4f7a1affdcf52e756ae5e81497c471f-5472x3648.jpg?fit=crop&auto=format" alt="Atopic dermatitis | Image credit: Ольга Тернавская - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 27th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/more-than-half-of-adults-with-moderate-to-severe-ad-report-conditions-that-may-influence-selection-of-jak-inhibitors">More Than Half of Adults With Moderate to Severe AD Report Conditions That May Influence Selection of JAK Inhibitors</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/emma-andrus">Emma Andrus</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/more-than-half-of-adults-with-moderate-to-severe-ad-report-conditions-that-may-influence-selection-of-jak-inhibitors"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The most common conditions or concerns patients with atopic dermatitis (AD) reported having that may influence their selection of a JAK inhibitor included an increased risk of MACE and an age above 65 years.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-clinician-education-needed-to-overcome-ad-treatment-barriers"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f70b3c100a1f2229ee8053058243a4d51720194f-2865x1615.png?fit=crop&auto=format" alt="dr april armstrong" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 26th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-clinician-education-needed-to-overcome-ad-treatment-barriers">Dr April Armstrong: Clinician Education Needed to Overcome AD Treatment Barriers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hayden-e-klein">Hayden E. Klein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-clinician-education-needed-to-overcome-ad-treatment-barriers"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">April Armstrong, MD, MPH, of University of California, Los Angeles, gave an overview of her Fall Clinical Dermatology session on treating atopic dermatitis (AD) in patients with diverse skin tones and weighed in on how to address related treatment barriers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-identifies-main-ad-health-care-gaps"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f70b3c100a1f2229ee8053058243a4d51720194f-2865x1615.png?fit=crop&auto=format" alt="dr april armstrong" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 24th 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-identifies-main-ad-health-care-gaps">Dr April Armstrong Identifies Main AD Health Care Gaps</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hayden-e-klein">Hayden E. Klein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-april-armstrong-identifies-main-ad-health-care-gaps"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">April Armstrong, MD, MPH, of University of California, Los Angeles, explained that the main health care gap within the atopic dermatitis (AD) realm is that many clinicians are not comfortable prescribing systemic medications.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/atopic-dermatitis?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/atopic-dermatitis?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/atopic-dermatitis?page=3">3</a><a class="px-4 py-2 border-y border-r " 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pediatric dermatology at Rady Children's Hospital in San Diego and professor of dermatology and pediatrics at the University of California, San Diego, presented late-breaking findings from the INTEGUMENT-PED phase 3 randomized controlled trial of roflumilast cream 0.05% in children 2 to 5 years of age with atopic dermatitis (AD). 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He noted that he is looking forward to roflumilast cream being \"hopefully approved\" and \"potentially having this in our armamentarium for treating young children.\"","_key":"198998652e4b","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"fb1b2be47f13"},{"style":"normal","_key":"1d53b5bf0b22","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bfa4ab902a1b"}],"_type":"block"},{"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"ff250d953162"}],"_type":"block","style":"normal","_key":"e48ed445cd96","markDefs":[]},{"style":"normal","_key":"d3be5c98307f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"053cd448f217"}],"_type":"block"},{"_type":"block","style":"normal","_key":"3485545bb284","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How do the results of the INTEGUMENT-PED study contribute to our understanding of AD treatment options for young children? What implications might they have for clinical practice and future research?","_key":"438dad422457"}]},{"markDefs":[],"children":[{"text":" ","_key":"33b853704820","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"f353fba6bebe"},{"markDefs":[],"children":[{"marks":[],"text":"First, to go through some of the basics, the study hit the sort of standard outcome measures that we look for. What percentage of patients made it to clear or almost cleared? About 25% of those were within a 4-week time period with once-a-day application with a big delta, or almost 15% delta, between the vehicle.","_key":"a628df170ce50","_type":"span"}],"_type":"block","style":"normal","_key":"94b0f68b8b27"},{"_key":"e2f20eb3adfe","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b544179966ce"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"It was very interesting to me that a lot of the population that got that clear, or almost clear, were already clear or almost clear by 2 weeks, and there was almost 80 something percent of those because it was 21% of the patients made clear or almost clear at week 2. ","_key":"870997c6b549","_type":"span"}],"_type":"block","style":"normal","_key":"db9fcb3e0f2b"},{"_key":"6bf8f16d6682","markDefs":[],"children":[{"text":"","_key":"2f0452be7239","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_key":"1b97a6ffb9f8","markDefs":[],"children":[{"_key":"15a390b1134e","_type":"span","marks":[],"text":"The secondary outcome measures being clear or almost clear at EASI [Eczema Area and Severity Index] 75, and the percentage of patients who had at least a 4-part drop in itch as compared to their baseline was consistent with a nice separation from the vehicle cream throughout the course of the study. "}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"1a3672467aa6"}],"_type":"block","style":"normal","_key":"40de91023b82","markDefs":[]},{"children":[{"text":"When we looked very early, the improvement in the itch with roflumilast was seen as early as 24 hours after the first application. 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Dermatology Annual Meeting","_key":"50a5f42e75d2"},{"_type":"span","marks":[],"text":", Lawrence Eichenfield, MD, chief of pediatric dermatology at Rady Children's Hospital - San Diego and professor of dermatology and pediatrics at University of California, San Diego, presented late-breaking findings of roflumilast cream 0.05% in children aged 2 to 5 years with atopic dermatitis (AD) from the INTEGUMENT-PED phase 3 randomized controlled trial. ","_key":"4f85170bad1d"}]},{"_key":"ae36cf2ebedb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f0bf528eaf2d"}],"_type":"block","style":"normal"},{"style":"normal","_key":"74bed3000d8e","markDefs":[],"children":[{"_key":"f161aeda5d11","_type":"span","marks":[],"text":"In this interview with "},{"_type":"span","marks":["em"],"text":"AJMC","_key":"f3c99bc55c04"},{"_type":"span","marks":[],"text":", Eichenfield says that roflumilast cream 0.05% had \"very good results\" in pediatric patients with AD in terms of efficacy and safety. ","_key":"4e1a012f8ade"}],"_type":"block"},{"children":[{"_key":"70be043cd0e3","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"7a5f7360e76a","markDefs":[]},{"markDefs":[],"children":[{"marks":["strong","underline"],"text":"Transcript","_key":"eb418164f097","_type":"span"}],"_type":"block","style":"normal","_key":"23fcfbb03857"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d9ecd07e8d9e"}],"_type":"block","style":"normal","_key":"b3e41335eee6"},{"markDefs":[],"children":[{"text":"Can you provide an overview of the primary findings from INTEGUMENT-PED, the phase 3 study assessing the efficacy and safety of once-daily roflumilast cream 0.05% in pediatric patients with AD?","_key":"fb4121eb35a50","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"88cc794344da"},{"children":[{"_type":"span","marks":[],"text":"","_key":"f193587f93b9"}],"_type":"block","style":"normal","_key":"19d0776f1a83","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"First of all, roflumilast is a topical PDE-4 [phosphodiesterase-4] inhibitor, and this drug is approved right now at a 0.3% strength for psoriasis as a cream and as a foam for seborrheic dermatitis. ","_key":"b32c70588e750"}],"_type":"block","style":"normal","_key":"236ea6f556a0","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"f29a7b956e47"}],"_type":"block","style":"normal","_key":"ed2ed44237db","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"This study fits into the earlier portfolio of studies looking at roflumilast cream for atopic dermatitis. There had been a study in patients 6 years of age and older through adults, studying roflumilast 0.15% cream application for atopic dermatitis. ","_key":"0881b7bbfe72","_type":"span"}],"_type":"block","style":"normal","_key":"57652527d1f9"},{"_key":"2130be685d34","markDefs":[],"children":[{"text":"","_key":"00e2a94d1bf3","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"This is the study of patients 2 to 5 years of age with mild to moderate atopic dermatitis, using a formulation of roflumilast cream, which is 0.05%. The study was done in a typical fashion and showed very good results in terms of the core standard end points that we look for, for both efficacy and safety, as a topical for atopic dermatitis in this pediatric population.","_key":"afa9c95d8ae8"}],"_type":"block","style":"normal","_key":"90b3fcdfdf2b"},{"_key":"42b907bcfafa","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9a4e5b9de71d"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"c3a6bcd34485","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What were the key inclusion criteria for selecting participants in this study? How representative were they of the pediatric population with AD?","_key":"70474089ab2c"}]},{"_type":"block","style":"normal","_key":"a6ac608cdc56","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e57d114c58cf"}]},{"children":[{"_type":"span","marks":[],"text":"Patients in this study had to be 2 to 5 years of age with mild to moderate atopic dermatitis. They had to have a minimum body surface area of 3%, and they had to have an EASI [Eczema Area and Severity Index]","_key":"4db388fc5d400"},{"_type":"span","marks":["strong"],"text":" ","_key":"57bc8dd5895b"},{"_key":"4338dd5bb9a7","_type":"span","marks":[],"text":"score that was 5 or greater. That's a pretty typical population within this age group, for 2 to 5 year olds. We have a lot of mild or moderate atopic dermatitis in that subgroup—the 3% body surface area—it's just not including those with little focal area of atopic dermatitis. Baseline EASI was consistent with that. "}],"_type":"block","style":"normal","_key":"b33c2e3d4808","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2665c974bd02"}],"_type":"block","style":"normal","_key":"dd977262a953"},{"_key":"891a50b7a8d9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, it doesn't represent all patients, just within that little age group, but it's a pretty reasonable inclusion criteria for much of the eczema that we see in younger children.","_key":"aa8001a63dea"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"42a8fd51a298","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"527df700c38d"},{"markDefs":[],"children":[{"text":"Could you provide insights into the safety profile of roflumilast cream observed during the trial? Were there any unexpected adverse events or safety concerns in this pediatric population?","_key":"01ddbe827e55","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"bdef2ed379fb"},{"_type":"block","style":"normal","_key":"b395c6726f2a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c3468a30f0fa"}]},{"style":"normal","_key":"80cdb810dcd2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"This study was using the drug as a daily application as compared to vehicle cream for a 4-week time period. There was a very low dropout rate during the study, something that we like to see in topical studies so that we don't have a sense that patients abandoned the study because of problems with either safety or tolerance, which are, I think, the 2 aspects when it comes to a topical that we're looking at. ","_key":"5bad6191c5b70"}],"_type":"block"},{"children":[{"text":"","_key":"dd5f6291946b","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"0f57350a66e4","markDefs":[]},{"markDefs":[],"children":[{"_key":"5880887274b2","_type":"span","marks":[],"text":"The drug appeared to be quite successful from a safety standpoint. The treatment adverse events, there was 1 serious adverse event. It was cellulitis within a few days of the study, not considered to be associated with a drug; no other serious adverse events in either group. The rate of immersion adverse events that led to discontinuation was very low, around the 1% range with roflumilast and about twice that, actually, in the vehicle group. There was a little bit of a upper respiratory infection that was seen with roflumilast, and then a little bit of diarrhea and vomiting that was a little higher than the vehicle group; this was generally quite mild and considered unrelated in most of the patients. 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response?","_key":"da7e761cc0740","_type":"span"}],"_type":"block","style":"normal","_key":"3ce7a4c7c793","markDefs":[]},{"_type":"block","style":"normal","_key":"72f0b11f7bfc","markDefs":[],"children":[{"_key":"8495b5c684b0","_type":"span","marks":[],"text":""}]},{"_type":"block","style":"normal","_key":"c0dfd2f48189","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I like to tell individuals that I chat with about oral JAK inhibitors, don't be scared or frightened or even a little nervous about the fact that maybe there's a couple more points that you're going to talk about with your patients. If anything, that just makes you a better and more well-informed clinician to really be thinking about what is going to be the best therapy for that patient in front of you. ","_key":"d0337b1076e50"}]},{"style":"normal","_key":"5a7d50e9a1af","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6180bcc7e78d"}],"_type":"block"},{"style":"normal","_key":"5149e648d722","markDefs":[],"children":[{"_type":"span","marks":[],"text":"When it comes to starting and initiation, on label, both JAK inhibitors abrocitinib and upadacitinib recommend starting at the lowest dose; that would be 100 milligrams of abrocitinib, 15 milligrams for upadacitinib. Then, based on your clinical assessment, if someone was not getting an optimal response—and that could include you feeling like they're not getting fast enough resolution of their itch or lesions—you can bump them up to the higher dose. ","_key":"4c6d2a50c8a4"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"58b5817eb9ce"}],"_type":"block","style":"normal","_key":"92a94274f17e"},{"_key":"d3d425ffaf17","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Now, in terms of monitoring, there's a few labs that we think about monitoring at baseline. Generally, some of the normal infectious stuff we do, just like other systemic therapies, hepatitis B, hepatitis C, TB [tuberculosis] testing. ","_key":"7dd807eda686"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"","_key":"bc3250d5a8cb","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"77e3f1dd5135"},{"children":[{"_type":"span","marks":[],"text":"Then, some of the other additional labs. In the case of abrocitinib, you're going to be thinking about doing a CBC [complete blood count], and, let's say, lipid profile at baseline, and then about 4 weeks after. Then, if you're going to be making a dosing change, another 4 weeks after that. ","_key":"7a471e572703"}],"_type":"block","style":"normal","_key":"131dcab7b7d6","markDefs":[]},{"_type":"block","style":"normal","_key":"e19892007fcc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"60fe1c9308a7"}]},{"_key":"d2bba5108c4a","markDefs":[],"children":[{"text":"In the case of upadacitinib, slightly different labs. You're going to be doing the same CBC and lipid panel, but also you're going to be adding on liver function tests. Typically, you're going to be taking a look at baseline and then as clinically indicated for most of these. Twelve weeks is kind of a good number that I like just because that's when you're going to be checking lipids anyway. 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So, I'll start with the good stuff. ","_key":"fc228a19998c0"}],"_type":"block","style":"normal"},{"_key":"f9ababf520ff","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"24d428a2164c"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"fc82cec735c7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"When it comes to thinking about oral JAK inhibitors, particularly at their higher dosing—both abrocitinib and upadacitinib have a lower dose and a higher dose)—it's some of the highest efficacy we've really ever seen for atopic dermatitis therapies. There's been a variety of indirect comparisons in recent years using what's called a network meta-analysis to sort of compare across different trials. What ends up coming out every single time, typically, is that upadacitinib 30 milligrams and abrocitinib 200 milligrams tend to be your best shot at getting the highest rates of clearance and also getting the highest rates of itch response. 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","_key":"87bbb2d1445c"}],"_type":"block","style":"normal","_key":"6c729c882350","markDefs":[]},{"markDefs":[],"children":[{"_key":"52c52fde6b23","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"a89bf18aa540"},{"_type":"block","style":"normal","_key":"de1e2a02dddb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Conversely, Paller noted that the long-term side effects of systemic therapies are not yet known, which, she emphasized, providers must be aware of when using them to treat children with AD. 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For others, we have to think about the fact that it can be a real struggle, and we may not be able to get past that struggle for the child and have to think about other ways to treat with oral medication.","_key":"9d8cf5c9f406","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"a283c533ad97"},{"children":[{"_type":"span","marks":[],"text":"","_key":"25c6830fa453"}],"_type":"block","style":"normal","_key":"25a11c5409f3","markDefs":[]},{"_key":"bcc0453706d9","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Are there any lifestyle changes or additional treatments that can complement systemic therapies for better results?","_key":"089851f3043a"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"0d272bf619cc"}],"_type":"block","style":"normal","_key":"3a7cf18e761e","markDefs":[]},{"_type":"block","style":"normal","_key":"e864badd63e5","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We don't give anyone systemic therapies only. We, of course, complement them with topical therapies to try to get that child 100% clear. We also do other things, like continue the use of emollients; they're critically important to reduce dryness and improve the barrier function of the skin. ","_key":"be530338c7580"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"4aec0d2c1390","_type":"span"}],"_type":"block","style":"normal","_key":"45fa496954f8"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"We encourage people to have a healthy lifestyle in all ways, and that means keeping a neat house and trying to reduce dust and clutter in homes that can increase the risk for many of these children who also have a tendency towards allergic disorders. ","_key":"e96a1108eb9e"}],"_type":"block","style":"normal","_key":"97d744274088"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"a9c77effe75d","_type":"span"}],"_type":"block","style":"normal","_key":"cd7adb4263f7"},{"_key":"1d06d7516d1f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We also, in general, just consider a healthy lifestyle for the entire family to be important because good diet and exercise are important for good health for everyone.","_key":"2b007d05ce8b"}],"_type":"block","style":"normal"}],"_rev":"7DPdpVQfYdDKlkK5xRe1Ba","published":"2024-03-12T16:00:00.000Z","thumbnail":{"asset":{"_updatedAt":"2024-03-11T15:32:52Z","mimeType":"image/png","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/1d4aff0d6882d93a42af0e26832541a9d5658f3d-2880x1535.png","_createdAt":"2024-03-11T15:32:52Z","_id":"image-1d4aff0d6882d93a42af0e26832541a9d5658f3d-2880x1535-png","sha1hash":"1d4aff0d6882d93a42af0e26832541a9d5658f3d","metadata":{"lqip":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABQAAAALCAYAAAB/Ca1DAAAACXBIWXMAABYlAAAWJQFJUiTwAAADFUlEQVQokR3F6U+aBwDA4ffDlmXZEpPtw850i3Hd0jabH7bVttZjPeyKaMVJrAxFW4avoiL4cniLUFrxoq1Hi4pXKYgWjYoiVaujJXSryLb/57dsH548wnLsGO9GiseRNKG9f/BH00yuHTG8/Cd9/tdY5xIYpuI0TB7QMhWn+0kSR+A1rmCS4VAS3/of7BymSCTTHMRTCDPbx8xsp5nb+Qv/879ZjKaZ3TpmYfuYxY0knpkwbXYPOusAotOH8VEM23wCafYVxumX3HmaIBh9Q2T/DaFIEiGwe0xwN/2/lb00z/bShHbTrO2nWFpaxS4Z0civofgpn/KyCpq6RnDN7+Jc/B3bzAF9C3EeriTwrSWYDr9EWN07YnUvxX9vHaTYPjhi80WK9dgrRt1D3FaUUHe9iMrCQvKys6lUqnCPL+INxnjwJMqIf5+RwCEPlw6ZWD5ECEQS+DfiLG8nWIslCUcTrO4k8YefY7V0oiotw3KrHqlWpDjvErKr1+noH2Z87hme6RCuRys4vevc80Vw+SIID/w7OCdCjC5sMhV+wWRgi3H/JoPeJXR6CZVCSU+jiXumbnRKDTfk5dQbu7C6xpD6PTT3jNLaP0aH24t014vQdj9ItXUU/d1Zeh+H6b0/T6d7Ask+TM1vBirLNXQ0tuM2OxFV9fx8TUm5Wo9KtHCrpZ1Gcy9N5h5abT00Sl0IFZ3jFIl2FKZBRMc4bfYhDLY+RGM3yupOLhVZ0fzqwN42gFbVSk5ONTkFOhRVBsQWiWaTBW1jK2KTAUkyI5RZBik1Oqloc1Jnc9Bg60LbKqGsa+f7Aiefn7xDboEbk34IXXU3Z0438+mXBvKvWFDXNlFRpUamuEmVWoOhRY9Q09FPlbkTpcFEudiAQqulpFbLObmJj046eOdDF1lnBqlRe6i+OUBmVhfvZlj54isDP+Yq+OHiec4WXuSy7AolChmC1tjCL7fVXK0s5kLJZXKLZeTdqOBUvkjGiR7eznDyceYQxaVjyOUePjnh4K33bLz/gZbPMi/wdXYW3577huzc03x3/hT/AumgI9ktm6ZqAAAAAElFTkSuQmCC","dimensions":{"width":2880,"aspectRatio":1.8762214983713354,"height":1535,"_type":"sanity.imageDimensions"},"isOpaque":true,"blurHash":"MaE{|lx]yCR-Vs?woKxcR*RiSjWBnza~of","_type":"sanity.imageMetadata","palette":{"_type":"sanity.imagePalette","darkMuted":{"foreground":"#fff","title":"#fff","population":1.71,"background":"#34516b","_type":"sanity.imagePaletteSwatch"},"muted":{"background":"#588db5","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":3.7},"lightVibrant":{"foreground":"#000","title":"#fff","population":0,"background":"#7cc4dc","_type":"sanity.imagePaletteSwatch"},"darkVibrant":{"background":"#060f83","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":5.48},"lightMuted":{"background":"#b4bfcf","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":6.33},"vibrant":{"background":"#0e26a8","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0.18},"dominant":{"background":"#b4bfcf","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":6.33}},"hasAlpha":true},"path":"images/0vv8moc6/ajmc/1d4aff0d6882d93a42af0e26832541a9d5658f3d-2880x1535.png","originalFilename":"Screenshot 2024-03-11 at 10.54.43 AM.png","size":4975558,"assetId":"1d4aff0d6882d93a42af0e26832541a9d5658f3d","extension":"png","uploadId":"QEgPAMgWnuwTdNDEU4ehx8tFbfl7BGHZ","_rev":"gFXie0Ldruy1o91XpplTZ7","_type":"sanity.imageAsset"}},"_type":"article","title":"Dr Amy Paller Discusses Using Systemic Therapies to Treat Children With AD","ExcludeFromPubMedXML":false,"updatedOn":null,"contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"summary":"Amy S. Paller, MD, chair of the department of dermatology at Feinberg School of Medicine at Northwestern University, discussed using systemic therapies to treat children with atopic dermatitis (AD)."},{"internalTag":["dr elaine siegfried","atopic dermatitis ","AAD guidelines","interview"],"ExcludeFromPubMedXML":false,"title":"Dr Elaine Siegfried Summarizes AD Treatment Guideline Update ","_updatedAt":"2024-01-10T18:52:48Z","published":"2024-01-10T19:00:43.038Z","_type":"article","factCheckAuthorMapping":null,"is_visible":true,"source":null,"_createdAt":"2024-01-10T16:35:38Z","contentCategory":{"_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos"},"body":[{"disableAutoPlayVideo":false,"source":"brightcove","_key":"0e361de8fcf2","videoObject":{"thumbnail":{"_type":"image","asset":{"_type":"reference","_ref":"image-db081c0c2b277892b449c8e2f422df0bd8a61a80-2351x1612-png"}},"videoDuration":"PT6M50S","videoDescription":"dr elaine siegfried, interview, atopic dermatitis, treatment guideline","_type":"videoDetails","videoTitle":"Dr Elaine Siegfried Summarizes AD Treatment Guideline Update "},"_type":"video","videoID":"6344633824112"},{"_key":"4e563c000b02","markDefs":[{"blank":true,"_type":"link","href":"https://medfaculty.slu.edu/details/548/elaine-siegfried-dermatology-pediatric_dermatology-chesterfield-lake_st_louis-st_louis","_key":"c6799c23344d","nofollow":true},{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/view/aad-updates-guidelines-for-ad-treatment-using-phototherapy-systemic-therapies","_key":"f8868f9b6353"},{"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/atopic-dermatitis","_key":"c9581cfb5793","nofollow":false}],"children":[{"_type":"span","marks":[],"text":"In this interview, ","_key":"4216f00e18f9"},{"_type":"span","marks":["c6799c23344d"],"text":"Elaine Siegfried, MD","_key":"3cdbc069e5761"},{"text":", of Saint Louis University School of Medicine, summarized the American Academy of Dermatology (AAD) ","_key":"3cdbc069e5762","_type":"span","marks":[]},{"_type":"span","marks":["f8868f9b6353"],"text":"guideline update","_key":"609ddf284ff7"},{"_type":"span","marks":[],"text":" published in November 2023 about treating ","_key":"c9c99cdec202"},{"_key":"3e6c120f5c21","_type":"span","marks":["c9581cfb5793"],"text":"atopic dermatitis (AD)"},{"marks":[],"text":" using phototherapy and systemic therapies. She also gave her opinion on guidelines overall.","_key":"20699409f05e","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"135e72ed5387","_type":"span"}],"_type":"block","style":"normal","_key":"b6bf7e91e835"},{"markDefs":[],"children":[{"marks":[],"text":"Siegfried diagnoses and treats skin-related disorders in infants and children; her specialties include AD, psoriasis, vascular birthmarks, and other eczemas. She is interested in research that investigates AD and pediatric drug development, as she participates in clinical trials for new eczema and psoriasis treatments. Siegfried is also a professor of pediatrics and dermatology in the Department of Pediatrics, Division of Dermatology, Saint Louis University School of Medicine.\n","_key":"c036dd3ff8a70","_type":"span"}],"_type":"block","style":"normal","_key":"fcf302bc8918"},{"_key":"270643351c11","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"6cccd1bd23b0"}],"_type":"block","style":"normal"},{"_key":"b98fad72df53","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1ba08c96b421"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":["strong"],"text":"Could you please summarize the AAD's updated guideline recommendations for phototherapy and systemic therapies?","_key":"39a7e047b90b0"}],"_type":"block","style":"normal","_key":"b1852e27f5ee","markDefs":[]},{"_type":"block","style":"normal","_key":"2fef6221223b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"649379bb59c60"}]},{"children":[{"_type":"span","marks":[],"text":"Just as by way of background, The last comprehensive guidelines were published in the ","_key":"a9651266279e"},{"_type":"span","marks":["em"],"text":"Journal of the American Academy of Dermatology ","_key":"ef7e274b10be"},{"_key":"5d6497ce05d3","_type":"span","marks":[],"text":"in 2014. Because so much has happened with this disease and new drug development for this spectrum of problems, the updated guidelines are much narrower just to try to bite off a smaller piece of that. So, the most recently published guidelines really focused on adults, and they focused on systemic treatments and phototherapy. The summary was very simple, and, just to put that into perspective, guidelines are something that requires broad consensus agreement and tries to look for evidence basis to support that agreement, but, just by virtue of the nature of trying to make guidelines, they're essentially really just oversimplified and are very difficult to draw generalized conclusions about how to manage any individual patient because individual patients are much more complicated than guidelines in general. "}],"_type":"block","style":"normal","_key":"c6783de38ea5","markDefs":[]},{"style":"normal","_key":"68a395e6d135","markDefs":[],"children":[{"marks":[],"text":"","_key":"3f9128872987","_type":"span"}],"_type":"block"},{"_key":"f42fb67b3fb3","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, the one take-home message that I think there was in this publication was, in no uncertain terms, systemic corticosteroids are considered not a good treatment and even relatively contraindicated, even though that's one of the very few medications that's essentially FDA approved for this condition. That speaks to the issues related to FDA approval and restricting access to medications based on FDA approval and particularly restricting things like step edits based on what's historically been FDA approved. ","_key":"195fb42a74c6"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7ce966640f03"}],"_type":"block","style":"normal","_key":"d2906ec356a1"},{"style":"normal","_key":"b79f5ebb1566","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Then, they also concentrated on phototherapy, talking about phototherapy in adults. It's an age old treatment, recommended narrowband UV-B as opposed to something like PUVA [psoralen plus UV-A], which has a little bit more risk and less well studied, but it really emphasized the fact that phototherapy is incredibly time consuming. While they didn't say this in the guidelines, and didn't address children at all, many people just can't afford the time; it requires 3 times a week and office visits for a minimum of 2 to 3 months. Then, after that, twice a week, and then, after that, long term. ","_key":"9cc67b63db67"}],"_type":"block"},{"_key":"0972d589564c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2ce9730650de"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"9cd2851c8f7d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"They did talk about the the possibility of combining treatments, phototherapy and systemic treatments, or even more than one systemic treatment, which really speaks to the difficulty in treating this condition. Some cases are so severe that you can't really go by what's FDA approved or a single agent to keep the disease under control. So, they didn't say anything about children and phototherapy, but the time commitment is even harder for children who need to be in school and depend on parents for transportation, things like that. ","_key":"b34f264b35e8"}]},{"_key":"265d2f3ca3dd","markDefs":[],"children":[{"marks":[],"text":"","_key":"b9a1f7bc8dcf","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Of the medications that they discussed, they recommended the FDA-approved ones with confidence, and that's strictly because we have level 1 prospective, double blind, placebo controlled trial data that support efficacy, and that's for adults. For children, it's a little bit different, and just so everyone knows, the number of children included in clinical trials to get that same kind of level 1 evidence is typically one-tenth the number of adults that are included in clinical trials, so much harder to have confidence, particularly in the safety data for such small number of patients and a unique subgroup of patients.","_key":"7b9a0ce4743c"}],"_type":"block","style":"normal","_key":"cc7945fe5a58"},{"style":"normal","_key":"11887dd6e72e","markDefs":[],"children":[{"_key":"1024636f7c6a","_type":"span","marks":[],"text":""}],"_type":"block"},{"_key":"c7f967ebf27a","markDefs":[],"children":[{"text":"Although this guideline was focused on systemic treatment and phototherapy, they also mentioned topical medications that were available—topical corticosteroids, calcineurin inhibitors, pimecrolimus, tacrolimus, crisaborole ointment, and a PDE-4 [phosphodiesterase 4] inhibitor, and then a newer JAK [Janus kinase] inhibitor ruxolitinib cream. There are also some other topical medications that have been FDA approved since then that the guidelines does not include that are probably more promising than, and safer than, the ones that were mentioned. ","_key":"52737e5b6da6","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1f8ae6829b99"}],"_type":"block","style":"normal","_key":"9cd3ba4e4e8d"},{"style":"normal","_key":"1ff1c31b2c68","markDefs":[],"children":[{"text":"In terms of the systemic therapies, they recommended with some confidence the FDA approved treatments dupilumab, that's been FDA approved and available since 2017, and tralokilumab, which was FDA approved I think about a year ago. There is another one that they didn't mention, lebrikizumab, that works through the same mechanism, which is very close to approval. ","_key":"604b2a3c38b6","_type":"span","marks":[]}],"_type":"block"},{"_type":"block","style":"normal","_key":"0faf52e30626","markDefs":[],"children":[{"text":"","_key":"a782a5276714","_type":"span","marks":[]}]},{"children":[{"_type":"span","marks":[],"text":"Then, they recommended 2 FDA-approved JAK inhibitors, upadacitinib and abrocitinib, and mentioned, without the higher level of recommendation because of the quality of the supportive evidence, the systemic treatments that have been used for many, many, many years—over 50 in the case of methotrexate, probably 30 or 40 for cyclosporine, azathioprine less so, and mycophenolate mofetil less so, but those are considered in this publication to be immunosuppressants. I don't consider methotrexate as much of an immunosuppressant as cyclosporine, azathioprine, and mycophenolate; it's more of an immunomodulating agent.","_key":"56fe13200249"}],"_type":"block","style":"normal","_key":"c6b91654d409","markDefs":[]},{"style":"normal","_key":"cf0996641cff","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"82732e1dc3ab"}],"_type":"block"},{"_key":"6331abb4bd30","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Then, it mentioned systemic corticosteroids. There was a strong recommendation against using systemic corticosteroids, and, I do have to say, through some claims database information that we have, that's still probably the number 1 systemic treatment that is still being used in this population, certainly inexpensive, but leads to all kinds of problems when used either repeatedly or long term. 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Silverberg is a professor of dermatology and director of clinical research and patch testing at the George Washington University School of Medicine and Health Sciences.","_key":"c5e636def63e"}],"_type":"block"},{"_type":"block","style":"normal","_key":"67554111e0ee","markDefs":[],"children":[{"text":"","_key":"e0ebbc8f0105","_type":"span","marks":[]}]},{"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"7130e98ccd2a"}],"_type":"block","style":"normal","_key":"7a82f1bdf665","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1e119162a8e1"}],"_type":"block","style":"normal","_key":"79ba6eb175d0"},{"_key":"e223ed749a34","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How have JAK inhibitors changed the AD landscape since their FDA approval? 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","_key":"c90651b0a0440"}],"_type":"block"},{"markDefs":[],"children":[{"text":"","_key":"e11ebc96eea6","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"5ba10d6c3e64"},{"_type":"block","style":"normal","_key":"d65489e5b331","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think, first and foremost, JAK inhibitors offer us a new treatment option to reach those who've already had an inadequate response or adverse events to a prior systemic therapy; in the United States, that would be the on-label use. For some patients, they [JAK inhibitors] are the appropriate first-line systemic therapy to be considering in different clinical scenarios. For many patients where injections are just not preferred or ideal, having an oral option that's highly effective is truly welcome. ","_key":"e4ed90986b28"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"984e4b1f2c71"}],"_type":"block","style":"normal","_key":"dd37f6655062"},{"style":"normal","_key":"1f0b3cfe3937","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We have certainly seen an expansion of our toolbox for managing patients with atopic dermatitis, but we're starting now to understand additional subsets of patients that may benefit from JAK inhibitors, in particular that may not even be so appropriate for biologics. Perhaps patients with more seasonal, or intermittently severe, disease where use of a biologic doesn't really make so much sense in those patients with less chronic disease. Potentially, for patients who have much more fluctuating disease where sometimes they need a little more medicine to get them through a tough flare, a little less for flare prevention, we're seeing opportunities for dose flexibility. ","_key":"03e38ff9e52f"}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"a42ad4e66a39","_type":"span"}],"_type":"block","style":"normal","_key":"bc9ef0c29a58"},{"_key":"636ec4b95a07","markDefs":[],"children":[{"marks":[],"text":"Our whole paradigm is really starting to shift now with JAK inhibitors, and I think we have to figure out how we can best incorporate them into the overall approach of trying to achieve long-term control in the disease, but they're really giving us a whole new approach for how to do that.","_key":"bf7aa5c7fb91","_type":"span"}],"_type":"block","style":"normal"}],"url":{"current":"dr-jonathan-silverberg-lists-which-patients-with-ad-benefit-most-from-jak-inhibitors","_type":"slug"}}],"topArticlesData":[{"_id":"f13e1ed9-5a17-4b9c-97fc-fe9291489ad1","title":"Study Finds Increased Impaired Mobility by Sex, Age in Atopic Dermatitis","thumbnail":{"_type":"mainImage","alt":"man resting hands on top of walking cane | Image Credit: sergign - stock.adobe.com","asset":{"_ref":"image-e6b3b6b3d78e9239230f37b63841610cbf291d32-3794x2515-jpg","_type":"reference"}},"source":null,"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"url":"study-finds-increased-impaired-mobility-by-sex-age-in-atopic-dermatitis","summary":"Patients with atopic dermatitis, particularly males and those aged 40 to 59 years, have significantly higher rates of impaired mobility.","published":"2024-06-30T13:00:00.000Z","updatedOn":null,"factCheckAuthors":null},{"_id":"14eb8e4b-07ea-4fc8-861b-d0383b13d56e","source":null,"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"title":"Parental e-Cigarette Use May Increase Pediatric AD Risk","url":"parental-e-cigarette-use-may-increase-pediatric-ad-risk","thumbnail":{"_type":"mainImage","alt":"E-cigarettes | Image Credit: lezinav - stock.adobe.com","asset":{"_ref":"image-f6215ae71443cb99064e408b0bbdecb1537b5add-5472x3648-jpg","_type":"reference"}},"summary":"Parental e-cigarette use was associated with an increased risk of pediatric atopic dermatitis (AD) in a new study.","published":"2024-05-22T15:05:00.000Z","updatedOn":null,"factCheckAuthors":null},{"title":"Study: Visible AD Impacts Romantic Relationships, Occupation, Sexual Health of French Female Patients ","url":"study-visible-ad-impacts-romantic-relationships-occupation-sexual-health-of-french-female-patients","thumbnail":{"_type":"mainImage","alt":"Female patient with AD | Image Credit: Prostock-studio - stock.adobe.com","asset":{"_ref":"image-bb58cbab9510b81e2030e6fd7b01c1172a3e319e-6720x4480-jpg","_type":"reference"}},"published":"2024-05-19T16:00:00.000Z","source":null,"authors":[{"displayName":"Brooke McCormick","url":"brooke-mccormick"}],"_id":"6b69d752-d56a-4b77-a9f0-6c82fe816d62","summary":"Atopic dermatitis (AD) in visible areas significantly impacts the romantic relationships, occupations, and sexual health of French female adult patients, according to a new study. 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