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markers</title> <meta name="description" content="Search results for: tumor markers"> <meta name="keywords" content="tumor markers"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="tumor markers"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1490</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: tumor markers</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1490</span> The Role of Genetic Markers in Prostate Cancer Diagnosis and Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farman%20Ali">Farman Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Asif%20Mahmood"> Asif Mahmood</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The utilization of genetic markers in prostate cancer management represents a significant advance in personalized medicine, offering the potential for more precise diagnosis and tailored treatment strategies. This paper explores the pivotal role of genetic markers in the diagnosis and treatment of prostate cancer, emphasizing their contribution to the identification of individual risk profiles, tumor aggressiveness, and response to therapy. By integrating current research findings, we discuss the application of genetic markers in developing targeted therapies and the implications for patient outcomes. Despite the promising advancements, challenges such as accessibility, cost, and the need for further validation in diverse populations remain. The paper concludes with an outlook on future directions, underscoring the importance of genetic markers in revolutionizing prostate cancer care. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=prostate%20cancer" title="prostate cancer">prostate cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20markers" title=" genetic markers"> genetic markers</a>, <a href="https://publications.waset.org/abstracts/search?q=personalized%20medicine" title=" personalized medicine"> personalized medicine</a>, <a href="https://publications.waset.org/abstracts/search?q=BRCA1%20and%20BRCA2" title=" BRCA1 and BRCA2"> BRCA1 and BRCA2</a> </p> <a href="https://publications.waset.org/abstracts/184866/the-role-of-genetic-markers-in-prostate-cancer-diagnosis-and-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184866.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">62</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1489</span> Effects of α-IFN –SingleWalled Carbon NanoTube and α-IFN-PLGA Encapsulated on Breast Cancer in Rats Induced by DMBA by Using CA15-3 Tumor Marker</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anoosh%20Eghdami">Anoosh Eghdami</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background and aim: Conventional anticancer drugs display significant shortcomings which limit their use in cancer therapy. For this reason, important progress has been achieved in the field of nanotechnology to solve these problems and offer a promising and effective alternative for cancer treatment. Tumor markers may also be measured periodically during cancer therapy. Tumor markers may also be measured after treatment has ended to check for recurrence the return of cancer. The aim of this study was to evaluate the effect of nano drug delivery in induced breast cancer with DMBA by using CA15-3 tumor marker. Material and method: the rats were divided into five groups. The first group (control n=15) were fed only sesame oil as a gavage. In the second group n=15,10 mg DMBA was dissolved in 5ml of sesame oil and were fed as a gavage. In addition to DMBA treatment as the second group, in the 3,4and 5 groups after cancer creation, respectively affected by alpha interferon (α-IFN),alpha interferon conjugated with single walled carbon nano tube (α-IFN-SWNT) and encapsulated in poly lactic poly glycolic acid (α-IFN-PLGA). Tumor marker was measured in recent three groups. Results: The ANOVA test was used to determine the differences among the groups. Cancer inducing in rats (group 2) caused a significant increase in blood levels of CA15-3 (P<0.05). Administration of α-IFN, α-IFN –SWNT and α-IFN-PLGA in 3 groups of cancerous rats caused a significant decrease in blood levels of CA15-3 only the group that treated with α-IFN-PLGA (p<0.05). Conclusion: the results of this study indicate that nano drugs more effective than traditional drug in cancer treatment, although further work is needed to elucidate the safety and side effect of these compound in human. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=nano%20drug" title=" nano drug"> nano drug</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20markers" title=" tumor markers"> tumor markers</a>, <a href="https://publications.waset.org/abstracts/search?q=CA15-3" title=" CA15-3"> CA15-3</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B1-IFN-PLGA" title=" α-IFN-PLGA"> α-IFN-PLGA</a>, <a href="https://publications.waset.org/abstracts/search?q=-IFN%20%E2%80%93SWNT" title=" -IFN –SWNT"> -IFN –SWNT</a> </p> <a href="https://publications.waset.org/abstracts/42105/effects-of-a-ifn-singlewalled-carbon-nanotube-and-a-ifn-plga-encapsulated-on-breast-cancer-in-rats-induced-by-dmba-by-using-ca15-3-tumor-marker" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42105.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">318</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1488</span> MSIpred: A Python 2 Package for the Classification of Tumor Microsatellite Instability from Tumor Mutation Annotation Data Using a Support Vector Machine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chen%20Wang">Chen Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chun%20Liang"> Chun Liang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microsatellite instability (MSI) is characterized by high degree of polymorphism in microsatellite (MS) length due to a deficiency in mismatch repair (MMR) system. MSI is associated with several tumor types and its status can be considered as an important indicator for tumor prognostic. Conventional clinical diagnosis of MSI examines PCR products of a panel of MS markers using electrophoresis (MSI-PCR) which is laborious, time consuming, and less reliable. MSIpred, a python 2 package for automatic classification of MSI was released by this study. It computes important somatic mutation features from files in mutation annotation format (MAF) generated from paired tumor-normal exome sequencing data, subsequently using these to predict tumor MSI status with a support vector machine (SVM) classifier trained by MAF files of 1074 tumors belonging to four types. Evaluation of MSIpred on an independent 358-tumor test set achieved overall accuracy of over 98% and area under receiver operating characteristic (ROC) curve of 0.967. These results indicated that MSIpred is a robust pan-cancer MSI classification tool and can serve as a complementary diagnostic to MSI-PCR in MSI diagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microsatellite%20instability" title="microsatellite instability">microsatellite instability</a>, <a href="https://publications.waset.org/abstracts/search?q=pan-cancer%20classification" title=" pan-cancer classification"> pan-cancer classification</a>, <a href="https://publications.waset.org/abstracts/search?q=somatic%20mutation" title=" somatic mutation"> somatic mutation</a>, <a href="https://publications.waset.org/abstracts/search?q=support%20vector%20machine" title=" support vector machine"> support vector machine</a> </p> <a href="https://publications.waset.org/abstracts/93236/msipred-a-python-2-package-for-the-classification-of-tumor-microsatellite-instability-from-tumor-mutation-annotation-data-using-a-support-vector-machine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93236.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">173</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1487</span> Interleukin-6 and Tumor Necrosis Factor-α Levels in Tear Film of Keratoconus Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mazdak%20Ganjalikhani">Mazdak Ganjalikhani</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamad%20Namgar"> Mohamad Namgar</a>, <a href="https://publications.waset.org/abstracts/search?q=Alireza%20Peyman"> Alireza Peyman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The present study was carried out to measure the levels of inflammatory markers Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in tear of keratoconus patients and investigate their relationship with the severity of keratoconus. Materials and Methods: This study was performed on 81 patients with keratoconus (cases) and 85 healthy individuals (controls) who were selected through the convenience sampling method from patients visiting the Feiz Ophthalmology Hospital affiliated with the Isfahan University of Medical Sciences. Tear levels of IL-6 and TNF-α were measured after collecting the patient's tears from the lower eyelid through the Schirmer I method using a filter paper (Schirmer tear test strip) without anesthesia. Findings: The mean levels of IL-6 and TNF-α were 26.77±8.16 and 34.58±9.82 in the control group and 103.22±51.94, and 183.76±54.61 in the case group, respectively, indicating a significant difference between two groups (p<0.05). In addition, there was a significant relationship between the severity of the keratoconus and the mean levels of TNF-α and IL-6 in the case group (p<0.05). Conclusion: According to the results, the mean levels of IL-6 and TNF-α were higher in keratoconus cases than in the controls, and the disease severity was significantly associated with the levels of inflammatory markers IL-6 and TNF-α. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=keratoonus" title="keratoonus">keratoonus</a>, <a href="https://publications.waset.org/abstracts/search?q=cataract" title=" cataract"> cataract</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20necrotic%20factor" title=" tumor necrotic factor"> tumor necrotic factor</a>, <a href="https://publications.waset.org/abstracts/search?q=interleukin%206" title=" interleukin 6"> interleukin 6</a> </p> <a href="https://publications.waset.org/abstracts/195133/interleukin-6-and-tumor-necrosis-factor-a-levels-in-tear-film-of-keratoconus-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/195133.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">4</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1486</span> Effect of Diindolylmethane on BBN-Induced Bladder Carcinogenesis in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sundaresan%20Sivapatham">Sundaresan Sivapatham</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Prabhu"> B. Prabhu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cancer results from a multistage, multi-mechanism carcinogenesis process that involves mutagenic, cell death and epigenetic mechanisms, during the three distinguishable but closely allied stages: initiation, promotion, and progression. Chemoprevention is promising in the realm of cancer prevention and it has been shown to reduce the risk of development of carcinoma in highly susceptible individuals such as those with known genetic mutations or high level of risk factors. The present study is aimed at the need of early detection of bladder cancer in order to improve performance in the treatment of this disease. Consumption of certain natural products like DIM is associated with a reduction in cancer incidence in humans. The study showed the protective effects of Diindolylmethane in N-Butyl-N-(4-hydroxybutyl) nitrosamine treated rats. Results of the study had shown the changes in the tumor markers, biomarkers and histopathological alterations in experimental rats when compared to control rats. The protective effects of DIM were shown from the results of cell proliferation, apoptotic markers and histopathological findings when compared with experimental control animals. Hence, our results speculate that the tumor markers, apoptotic markers, histopathological changes and cell proliferation index measured as PCNA serves as an indicator suggestive of protective effects of DIM in BBN induced urinary bladder carcinogenesis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bladder%20cancer" title="bladder cancer">bladder cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=N-Butyl-N-%284-hydroxybutyl%29%20nitrosamine" title=" N-Butyl-N-(4-hydroxybutyl) nitrosamine"> N-Butyl-N-(4-hydroxybutyl) nitrosamine</a>, <a href="https://publications.waset.org/abstracts/search?q=diindolylmethane" title=" diindolylmethane"> diindolylmethane</a>, <a href="https://publications.waset.org/abstracts/search?q=histopathology" title=" histopathology"> histopathology</a> </p> <a href="https://publications.waset.org/abstracts/37513/effect-of-diindolylmethane-on-bbn-induced-bladder-carcinogenesis-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37513.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">342</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1485</span> An Improved Circulating Tumor Cells Analysis Method for Identifying Tumorous Blood Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salvador%20Garcia%20Bernal">Salvador Garcia Bernal</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi%20Zheng"> Chi Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Keqi%20Zhang"> Keqi Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Lei%20Mao"> Lei Mao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Circulating Tumor Cells (CTC) is used to detect tumoral cell metastases using blood samples of patients with cancer (lung, breast, etc.). Using an immunofluorescent method a three channel image (Red, Green, and Blue) are obtained. These set of images usually overpass the 11 x 30 M pixels in size. An aided tool is designed for imaging cell analysis to segmented and identify the tumorous cell based on the three markers signals. Our Method, it is cell-based (area and cell shape) considering each channel information and extracting and making decisions if it is a valid CTC. The system also gives information about number and size of tumor cells found in the sample. We present results in real-life samples achieving acceptable performance in identifying CTCs in short time. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Circulating%20Tumor%20Cells%20%28CTC%29" title="Circulating Tumor Cells (CTC)">Circulating Tumor Cells (CTC)</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20analysis" title=" cell analysis"> cell analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=immunofluorescent" title=" immunofluorescent"> immunofluorescent</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20image%20analysis" title=" medical image analysis"> medical image analysis</a> </p> <a href="https://publications.waset.org/abstracts/81401/an-improved-circulating-tumor-cells-analysis-method-for-identifying-tumorous-blood-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81401.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">214</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1484</span> PCR Based DNA Analysis in Detecting P53 Mutation in Human Breast Cancer (MDA-468)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Debbarma%20Asis">Debbarma Asis</a>, <a href="https://publications.waset.org/abstracts/search?q=Guha%20Chandan"> Guha Chandan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor Protein-53 (P53) is one of the tumor suppressor proteins. P53 regulates the cell cycle that conserves stability by preventing genome mutation. It is named so as it runs as 53-kilodalton (kDa) protein on Polyacrylamide gel electrophoresis although the actual mass is 43.7 kDa. Experimental evidence has indicated that P53 cancer mutants loses tumor suppression activity and subsequently gain oncogenic activities to promote tumourigenesis. Tumor-specific DNA has recently been detected in the plasma of breast cancer patients. Detection of tumor-specific genetic materials in cancer patients may provide a unique and valuable tumor marker for diagnosis and prognosis. Commercially available MDA-468 breast cancer cell line was used for the proposed study. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tumor%20protein%20%28P53%29" title="tumor protein (P53)">tumor protein (P53)</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20mutants" title=" cancer mutants"> cancer mutants</a>, <a href="https://publications.waset.org/abstracts/search?q=MDA-468" title=" MDA-468"> MDA-468</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20suppressor%20gene" title=" tumor suppressor gene"> tumor suppressor gene</a> </p> <a href="https://publications.waset.org/abstracts/43690/pcr-based-dna-analysis-in-detecting-p53-mutation-in-human-breast-cancer-mda-468" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43690.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">480</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1483</span> Expression Profiling and Immunohistochemical Analysis of Squamous Cell Carcinoma of Head and Neck (Tumor, Transition Zone, Normal) by Whole Genome Scale Sequencing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Veronika%20Zivicova">Veronika Zivicova</a>, <a href="https://publications.waset.org/abstracts/search?q=Petr%20Broz"> Petr Broz</a>, <a href="https://publications.waset.org/abstracts/search?q=Zdenek%20Fik"> Zdenek Fik</a>, <a href="https://publications.waset.org/abstracts/search?q=Alzbeta%20Mifkova"> Alzbeta Mifkova</a>, <a href="https://publications.waset.org/abstracts/search?q=Jan%20Plzak"> Jan Plzak</a>, <a href="https://publications.waset.org/abstracts/search?q=Zdenek%20Cada"> Zdenek Cada</a>, <a href="https://publications.waset.org/abstracts/search?q=Herbert%20Kaltner"> Herbert Kaltner</a>, <a href="https://publications.waset.org/abstracts/search?q=Jana%20Fialova%20Kucerova"> Jana Fialova Kucerova</a>, <a href="https://publications.waset.org/abstracts/search?q=Hans-Joachim%20%20Gabius"> Hans-Joachim Gabius</a>, <a href="https://publications.waset.org/abstracts/search?q=Karel%20Smetana%20Jr."> Karel Smetana Jr. </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The possibility to determine genome-wide expression profiles of cells and tissues opens a new level of analysis in the quest to define dysregulation in malignancy and thus identify new tumor markers. Toward this long-term aim, we here address two issues on this level for head and neck cancer specimen: i) defining profiles in different regions, i.e. the tumor, the transition zone and normal control and ii) comparing complete data sets for seven individual patients. Special focus in the flanking immunohistochemical part is given to adhesion/growth-regulatory galectins that upregulate chemo- and cytokine expression in an NF-κB-dependent manner, to these regulators and to markers of differentiation, i.e. keratins. The detailed listing of up- and down-regulations, also available in printed form (1), not only served to unveil new candidates for testing as marker but also let the impact of the tumor in the transition zone become apparent. The extent of interindividual variation raises a strong cautionary note on assuming uniformity of regulatory events, to be noted when considering therapeutic implications. Thus, a combination of test targets (and a network analysis for galectins and their downstream effectors) is (are) advised prior to reaching conclusions on further perspectives. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=galectins" title="galectins">galectins</a>, <a href="https://publications.waset.org/abstracts/search?q=genome%20scale%20sequencing" title=" genome scale sequencing"> genome scale sequencing</a>, <a href="https://publications.waset.org/abstracts/search?q=squamous%20cell%20carcinoma" title=" squamous cell carcinoma"> squamous cell carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=transition%20zone" title=" transition zone"> transition zone</a> </p> <a href="https://publications.waset.org/abstracts/75823/expression-profiling-and-immunohistochemical-analysis-of-squamous-cell-carcinoma-of-head-and-neck-tumor-transition-zone-normal-by-whole-genome-scale-sequencing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75823.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">239</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1482</span> Ultra Wideband Breast Cancer Detection by Using SAR for Indication the Tumor Location</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wittawat%20Wasusathien">Wittawat Wasusathien</a>, <a href="https://publications.waset.org/abstracts/search?q=Samran%20Santalunai"> Samran Santalunai</a>, <a href="https://publications.waset.org/abstracts/search?q=Thanaset%20Thosdeekoraphat"> Thanaset Thosdeekoraphat</a>, <a href="https://publications.waset.org/abstracts/search?q=Chanchai%20Thongsopa"> Chanchai Thongsopa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents breast cancer detection by observing the specific absorption rate (SAR) intensity for identification tumor location, the tumor is identified in coordinates (x,y,z) system. We examined the frequency between 4-8 GHz to look for the most appropriate frequency. Results are simulated in frequency 4-8 GHz, the model overview include normal breast with 50 mm radian, 5 mm diameter of tumor, and ultra wideband (UWB) bowtie antenna. The models are created and simulated in CST Microwave Studio. For this simulation, we changed antenna to 5 location around the breast, the tumor can be detected when an antenna is close to the tumor location, which the coordinate of maximum SAR is approximated the tumor location. For reliable, we experiment by random tumor location to 3 position in the same size of tumor and simulation the result again by varying the antenna position in 5 position again, and it also detectable the tumor position from the antenna that nearby tumor position by maximum value of SAR, which it can be detected the tumor with precision in all frequency between 4-8 GHz. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=specific%20absorption%20rate%20%28SAR%29" title="specific absorption rate (SAR)">specific absorption rate (SAR)</a>, <a href="https://publications.waset.org/abstracts/search?q=ultra%20wideband%20%28UWB%29" title=" ultra wideband (UWB)"> ultra wideband (UWB)</a>, <a href="https://publications.waset.org/abstracts/search?q=coordinates" title=" coordinates"> coordinates</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20detection" title=" cancer detection"> cancer detection</a> </p> <a href="https://publications.waset.org/abstracts/10465/ultra-wideband-breast-cancer-detection-by-using-sar-for-indication-the-tumor-location" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10465.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">403</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1481</span> Discriminant Function Based on Circulating Tumor Cells for Accurate Diagnosis of Metastatic Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hatem%20A.%20El-Mezayen">Hatem A. El-Mezayen</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Abdelmajeed"> Ahmed Abdelmajeed</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatehya%20Metwally"> Fatehya Metwally</a>, <a href="https://publications.waset.org/abstracts/search?q=Usama%20Elsaly"> Usama Elsaly</a>, <a href="https://publications.waset.org/abstracts/search?q=Salwa%20Atef"> Salwa Atef</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor metastasis involves the dissemination of malignant cells into the basement membrane and vascular system contributes to the circulating pool of these markers. In this context our aim has been focused on development of a non-invasive. Circulating tumor cells (CTCs) represent a unique liquid biopsy carrying comprehensive biological information of the primary tumor. Herein, we sought to develop a novel score based on the combination of the most significant CTCs biomarkers with and routine laboratory tests for accurate detection of metastatic breast cancer. Methods: Cytokeratin 18 (CK18), Cytokeratin 19 (CK19), and CA15.3 were assayed in metastatic breast cancer (MBC) patients (75), non-MBC patients (50) and healthy control (20). Results: Areas under receiving operating curve (AUCs) were calculated and used for construction on novel score. A novel score named MBC-CTCs = CA15.3 (U/L) × 0.08 + CK 18 % × 2.9 + CK19 × 3.1– 510. That function correctly classified 87% of metastatic breast cancer at cut-off value = 0.55. (i.e great than 0.55 indicates patients with metastatic breast cancer and less than 0.55 indicates patients with non-metastatic breast cancer). Conclusion: MBC-CTCs is a novel, non-invasive and simple can applied to discriminate patients with metastatic breast cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=metastatic%20breast%20cancer" title="metastatic breast cancer">metastatic breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=circulating%20tumor%20cells" title=" circulating tumor cells"> circulating tumor cells</a>, <a href="https://publications.waset.org/abstracts/search?q=cytokeratin" title=" cytokeratin"> cytokeratin</a>, <a href="https://publications.waset.org/abstracts/search?q=EpiCam" title=" EpiCam"> EpiCam</a> </p> <a href="https://publications.waset.org/abstracts/146716/discriminant-function-based-on-circulating-tumor-cells-for-accurate-diagnosis-of-metastatic-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146716.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">214</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1480</span> CD133 and CD44 - Stem Cell Markers for Prediction of Clinically Aggressive Form of Colorectal Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ognen%20Kostovski">Ognen Kostovski</a>, <a href="https://publications.waset.org/abstracts/search?q=Svetozar%20Antovic"> Svetozar Antovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Rubens%20%20Jovanovic"> Rubens Jovanovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Irena%20%20Kostovska"> Irena Kostovska</a>, <a href="https://publications.waset.org/abstracts/search?q=Nikola%20Jankulovski"> Nikola Jankulovski</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction:Colorectal carcinoma (CRC) is one of the most common malignancies in the world. The cancer stem cell (CSC) markers are associated with aggressive cancer types and poor prognosis. The aim of study was to determine whether the expression of colorectal cancer stem cell markers CD133 and CD44 could be significant in prediction of clinically aggressive form of CRC. Materials and methods: Our study included ninety patients (n=90) with CRC. Patients were divided into two subgroups: with metatstatic CRC and non-metastatic CRC. Tumor samples were analyzed with standard histopathological methods, than was performed immunohistochemical analysis with monoclonal antibodies against CD133 and CD44 stem cell markers. Results: High coexpression of CD133 and CD44 was observed in 71.4% of patients with metastatic disease, compared to 37.9% in patients without metastases. Discordant expression of both markers was found in 8% of the subgroup with metastatic CRC, and in 13.4% of the subgroup without metastatic CRC. Statistical analyses showed a significant association of increased expression of CD133 and CD44 with the disease stage, T - category and N - nodal status. With multiple regression analysis the stage of disease was designate as a factor with the greatest statistically significant influence on expression of CD133 (p <0.0001) and CD44 (p <0.0001). Conclusion: Our results suggest that the coexpression of CD133 and CD44 have an important role in prediction of clinically aggressive form of CRC. Both stem cell markers can be routinely implemented in standard pathohistological diagnostics and can be useful markers for pre-therapeutic oncology screening. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colorectal%20carcinoma" title="colorectal carcinoma">colorectal carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cells" title=" stem cells"> stem cells</a>, <a href="https://publications.waset.org/abstracts/search?q=CD133%2B" title=" CD133+"> CD133+</a>, <a href="https://publications.waset.org/abstracts/search?q=CD44%2B" title=" CD44+"> CD44+</a> </p> <a href="https://publications.waset.org/abstracts/119672/cd133-and-cd44-stem-cell-markers-for-prediction-of-clinically-aggressive-form-of-colorectal-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/119672.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">150</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1479</span> Application of Molecular Markers for Crop Improvement</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Monisha%20Isaac">Monisha Isaac</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Use of molecular markers for selecting plants with desired traits has been started long back. Due to their heritable characteristics, they are useful for identification and characterization of specific genotypes. The study involves various types of molecular markers used to select multiple desired characters in plants, their properties, and advantages to improve crop productivity in adverse climatological conditions for the purpose of providing food security to fast-growing global population. The study shows that genetic similarities obtained from molecular markers provide more accurate information and the genetic diversity can be better estimated from the genetic relationship obtained from the dendrogram. The information obtained from markers assisted characterization is more suitable for the crops of economic importance like sugarcane. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=molecular%20markers" title="molecular markers">molecular markers</a>, <a href="https://publications.waset.org/abstracts/search?q=crop%20productivity" title=" crop productivity"> crop productivity</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20diversity" title=" genetic diversity"> genetic diversity</a>, <a href="https://publications.waset.org/abstracts/search?q=genotype" title=" genotype"> genotype</a> </p> <a href="https://publications.waset.org/abstracts/69621/application-of-molecular-markers-for-crop-improvement" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69621.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">517</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1478</span> Bioactive Chemical Markers Based Strategy for Quality Control of Herbal Medicines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zhenzhong%20Yang">Zhenzhong Yang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Herbal medicines are important supplements to chemical drugs and usually consist of a complex mixture of constituents. The current quality control strategy of herbal medicines is mainly based on chemical markers, which largely failed to owe to the markers, not reflecting the herbal medicines’ multiple mechanisms of action. Herein, a bioactive chemical markers based strategy was proposed and applied to the quality assessment and control of herbal medicines. This strategy mainly includes the comprehensive chemical characterization of herbal medicines, bioactive chemical markers identification, and related quantitative analysis methods development. As a proof-of-concept, this strategy was applied to a Panax notoginseng derived herbal medicine. The bioactive chemical markers based strategy offers a rational approach for quality assessment and control of herbal medicines. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bioactive%20chemical%20markers" title="bioactive chemical markers">bioactive chemical markers</a>, <a href="https://publications.waset.org/abstracts/search?q=herbal%20medicines" title=" herbal medicines"> herbal medicines</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20assessment" title=" quality assessment"> quality assessment</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20control" title=" quality control"> quality control</a> </p> <a href="https://publications.waset.org/abstracts/128810/bioactive-chemical-markers-based-strategy-for-quality-control-of-herbal-medicines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/128810.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">179</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1477</span> First Experimental Evidence on Feasibility of Molecular Magnetic Particle Imaging of Tumor Marker Alpha-1-Fetoprotein Using Antibody Conjugated Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kolja%20Them">Kolja Them</a>, <a href="https://publications.waset.org/abstracts/search?q=Priyal%20Chikhaliwala"> Priyal Chikhaliwala</a>, <a href="https://publications.waset.org/abstracts/search?q=Sudeshna%20Chandra"> Sudeshna Chandra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Purpose: The purpose of this work is to examine possibilities for noninvasive imaging and identification of tumor markers for cancer diagnosis. The proposed method uses antibody conjugated iron oxide nanoparticles and multicolor Magnetic Particle Imaging (mMPI). The method has the potential for radiation exposure free real-time estimation of local tumor marker concentrations in vivo. In this study, the method is applied to human Alpha-1-Fetoprotein. Materials and Methods: As tracer material AFP antibody-conjugated Dendrimer-Fe3O4 nanoparticles were used. The nanoparticle bioconjugates were then incubated with bovine serum albumin (BSA) to block any possible nonspecific binding sites. Parts of the resulting solution were then incubated with AFP antigen. MPI measurements were done using the preclinical MPI scanner (Bruker Biospin MRI GmbH) and the multicolor method was used for image reconstruction. Results: In multicolor MPI images the nanoparticles incubated only with BSA were clearly distinguished from nanoparticles incubated with BSA and AFP antigens. Conclusion: Tomographic imaging of human tumor marker Alpha-1-Fetoprotein is possible using AFP antibody conjugated iron oxide nanoparticles in presence of BSA. This opens interesting perspectives for cancer diagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=noninvasive%20imaging" title="noninvasive imaging">noninvasive imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20antigens" title=" tumor antigens"> tumor antigens</a>, <a href="https://publications.waset.org/abstracts/search?q=antibody%20conjugated%20iron%20oxide%20nanoparticles" title=" antibody conjugated iron oxide nanoparticles"> antibody conjugated iron oxide nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=multicolor%20magnetic%20particle%20imaging" title=" multicolor magnetic particle imaging"> multicolor magnetic particle imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20diagnosis" title=" cancer diagnosis"> cancer diagnosis</a> </p> <a href="https://publications.waset.org/abstracts/73134/first-experimental-evidence-on-feasibility-of-molecular-magnetic-particle-imaging-of-tumor-marker-alpha-1-fetoprotein-using-antibody-conjugated-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/73134.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">303</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1476</span> Comparative Assessment of ISSR and RAPD Markers among Egyptian Jojoba Shrubs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdelsabour%20G.%20A.%20Khaled">Abdelsabour G. A. Khaled</a>, <a href="https://publications.waset.org/abstracts/search?q=Galal%20A.R.%20El-Sherbeny"> Galal A.R. El-Sherbeny</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20M.%20Hassanein"> Ahmed M. Hassanein</a>, <a href="https://publications.waset.org/abstracts/search?q=Gameel%20M.%20G.%20Aly"> Gameel M. G. Aly </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Classical methods of identification, based on agronomical characterization, are not always the most accurate way due to the instability of these characteristics under the influence of the different environments. In order to estimate the genetic diversity, molecular markers provided excellent tools. In this study, Genetic variation of nine Egyptian jojoba shrubs was tested using ISSR (inter simple sequences repeats), RAPD (random amplified polymorphic DNA) markers and based on the morphological characterization. The average of the percentage of polymorphism (%P) ranged between 58.17% and 74.07% for ISSR and RAPD markers, respectively. The range of genetic similarity percents among shrubs based on ISSR and RAPD markers were from 82.9 to 97.9% and from 85.5 to 97.8%, respectively. The average of PIC (polymorphism information content) values were 0.19 (ISSR) and 0.24 (RAPD). In the present study, RAPD markers were more efficient than the ISSR markers. Where the RAPD technique exhibited higher marker index (MI) average (1.26) compared to ISSR one (1.11). There was an insignificant correlation between the ISSR and RAPD data (0.076, P > 0.05). The dendrogram constructed by the combined RAPD and ISSR data gave a relatively different clustering pattern. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=correlation" title="correlation">correlation</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20markers" title=" molecular markers"> molecular markers</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism"> polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=marker%20index" title=" marker index"> marker index</a> </p> <a href="https://publications.waset.org/abstracts/22213/comparative-assessment-of-issr-and-rapd-markers-among-egyptian-jojoba-shrubs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22213.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">478</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1475</span> The Role of Txnrd2 Deficiency in Epithelial-to-Mesenchymal-Transition (EMT) and Tumor Formation in Pancreatic Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chao%20Wu">Chao Wu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Thioredoxin reductase 2 is a mitochondrial enzyme that belongs to the cellular defense against oxidative stress. We deleted mitochondrial Txnrd2 in a KrasG12D-driven pancreatic tumor model. Despite an initial increase in precursor lesions, tumor incidence decreased significantly. We isolated cancer cell lines from these genetically engineered mice and observed an impaired proliferation and colony formation. Reactive Oxygen Species, as determined by DCF fluorescence, were increased. We detected a higher mitochondrial copy number in Txnrd2-deficient cells (KTP). However, measurement of mitochondrial bioenergetics showed no impairment of mitochondrial function and comparable O₂-consumption and extracellular acidification rates. In addition, the mitochondrial complex composition was affected in Txnrd2 deleted cell lines. To gain better insight into the role of Txnrd2, we deleted Txnrd2 in clones from parental KrasG12D cell lines using Crispr/Cas9 technology. The deletion was confirmed by western blot and activity assay. Interestingly, and in line with previous RNA expression analysis, we saw changes in EMT markers in Txnrd2 deleted cell lines and control cell lines. This might help us explain the reduced tumor incidence in KrasG12D; Txnrd2∆panc mice. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=PDAC" title="PDAC">PDAC</a>, <a href="https://publications.waset.org/abstracts/search?q=TXNRD2" title=" TXNRD2"> TXNRD2</a>, <a href="https://publications.waset.org/abstracts/search?q=epithelial-to-mesenchymal-transition" title=" epithelial-to-mesenchymal-transition"> epithelial-to-mesenchymal-transition</a>, <a href="https://publications.waset.org/abstracts/search?q=ROS" title=" ROS"> ROS</a> </p> <a href="https://publications.waset.org/abstracts/154620/the-role-of-txnrd2-deficiency-in-epithelial-to-mesenchymal-transition-emt-and-tumor-formation-in-pancreatic-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154620.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1474</span> An Analysis of Discourse Markers Awareness in Writing Undergraduate Thesis of English Education Student in Sebelas Maret University</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Oktanika%20Wahyu%20Nurjanah">Oktanika Wahyu Nurjanah</a>, <a href="https://publications.waset.org/abstracts/search?q=Anggun%20Fitriana%20Dewi"> Anggun Fitriana Dewi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An undergraduate thesis is one of the academic writings which should fulfill some characteristics, one of them is coherency. Moreover, a coherence of a text depends on the usage of discourse markers. In other word, discourse markers take an essential role in writing. Therefore, the researchers aim to know the awareness of the discourse markers usage in writing the under-graduate thesis of an English Education student at Sebelas Maret University. This research uses a qualitative case study in order to obtain a deep analysis. The sample of this research is an under-graduate thesis of English Education student in Sebelas Maret University which chosen based on some criteria. Additionally, the researchers were guided by some literature attempted to group the discourse markers based on their functions. Afterward, the analysis was held based on it. From the analysis, it found that the awareness of discourse markers usage is moderate. The last point, the researcher suggest undergraduate students to familiarize themselves with discourse markers, especially for those who want to write thesis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=discourse%20markers" title="discourse markers">discourse markers</a>, <a href="https://publications.waset.org/abstracts/search?q=English%20education" title=" English education"> English education</a>, <a href="https://publications.waset.org/abstracts/search?q=thesis%20writing" title=" thesis writing"> thesis writing</a>, <a href="https://publications.waset.org/abstracts/search?q=undergraduate%20student" title=" undergraduate student"> undergraduate student</a> </p> <a href="https://publications.waset.org/abstracts/60370/an-analysis-of-discourse-markers-awareness-in-writing-undergraduate-thesis-of-english-education-student-in-sebelas-maret-university" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60370.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">357</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1473</span> Evaluation of Tumor-Infiltrating Lymphocytes in Breast Carcinoma: Correlation with Molecular Subtypes and Clinicopathological Parameters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arundhathi%20S.">Arundhathi S.</a>, <a href="https://publications.waset.org/abstracts/search?q=Poongodi%20R."> Poongodi R.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor-infiltrating lymphocytes (TILs) are indicative of the local immune response against tumor proliferation and metastasis. Emerging as a significant marker of immune reactivity, TILs are utilized to evaluate prognostic outcomes across various malignancies, including colon, ovarian, lung, bladder, and breast cancers. In breast cancer (BC), TILs are particularly relevant for assessing tumor response to therapy in both adjuvant and neoadjuvant settings, with a prominent role in triple-negative breast cancer (TNBC), where they have been associated with improved outcomes. As such, TILs are recognized as an independent marker of favorable prognosis in several tumor types, underscoring their potential as a tool in personalized cancer therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=intratumoral%20TIL" title=" intratumoral TIL"> intratumoral TIL</a>, <a href="https://publications.waset.org/abstracts/search?q=stromal%20TIL" title=" stromal TIL"> stromal TIL</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20infiltrating%20lymphocytes" title=" tumor infiltrating lymphocytes"> tumor infiltrating lymphocytes</a> </p> <a href="https://publications.waset.org/abstracts/194529/evaluation-of-tumor-infiltrating-lymphocytes-in-breast-carcinoma-correlation-with-molecular-subtypes-and-clinicopathological-parameters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/194529.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">8</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1472</span> MicroRNA Expression Distinguishes Neutrophil Subtypes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20I.%20You">R. I. You</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20L.%20Ho"> C. L. Ho</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20S.%20Dai"> M. S. Dai</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20M.%20Hung"> H. M. Hung</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20F.%20Yen"> S. F. Yen</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20S.%20Chen"> C. S. Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Y.%20Chao"> T. Y. Chao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Neutrophils are the most abundant innate immune cells to against invading microorganisms. Numerous data shown neutrophils have plasticity in response to physiological and pathological conditions. Tumor-associated neutrophils (TAN) exist in distinct types of tumor and play an important role in cancer biology. Different transcriptomic profiles of neutrophils in tumor and non-tumor samples have been identified. Several miRNAs have been recognized as regulators of gene expression in neutrophil, which may have key roles in neutrophil activation. However, the miRNAs expression patterns in TAN are not well known. To address this question, magnetic bead isolated neutrophils from tumor-bearing mice were used in this study. We analyzed production of reactive oxygen species (ROS) by luminol-dependent chemiluminescence assay. The expression of miRNAs targeting NADPH oxidase, ROS generation and autophagy was explored using quantitative real-time polymerase chain reaction. Our data suggest that tumor environment influence neutrophil develop to differential states of activation via miRNAs regulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tumor-associated%20neutrophil" title="tumor-associated neutrophil">tumor-associated neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=miRNAs" title=" miRNAs"> miRNAs</a>, <a href="https://publications.waset.org/abstracts/search?q=neutrophil" title=" neutrophil"> neutrophil</a>, <a href="https://publications.waset.org/abstracts/search?q=ROS" title=" ROS "> ROS </a> </p> <a href="https://publications.waset.org/abstracts/13682/microrna-expression-distinguishes-neutrophil-subtypes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13682.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">470</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1471</span> The Simultaneous Application of Chemical and Biological Markers to Identify Reliable Indicators of Untreated Human Waste and Fecal Pollution in Urban Philadelphia Source Waters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Stafford%20Stewart">Stafford Stewart</a>, <a href="https://publications.waset.org/abstracts/search?q=Hui%20Yu"> Hui Yu</a>, <a href="https://publications.waset.org/abstracts/search?q=Rominder%20Suri"> Rominder Suri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper publishes the results of the first known study conducted in urban Philadelphia waterways that simultaneously utilized anthropogenic chemical and biological markers to identify suitable indicators of untreated human waste and fecal pollution. A total of 13 outfall samples, 30 surface water samples, and 2 groundwater samples were analyzed for fecal contamination and untreated human waste using a suite of 25 chemical markers and 5 bio-markers. Pearson rank correlation tests were conducted to establish associations between the abundances of bio-markers and the concentrations of chemical markers. Results show that 16S rRNA gene of human-associated Bacteroidales (BacH) was very strongly correlated (0.76 – 0.97, p < 0.05) with labile chemical markers acetaminophen, cotinine, estriol, and urobilin. Likewise, human-specific F- RNA coliphages (F-RNA-II) and labile chemical markers, urobilin, ibuprofen, cotinine and estriol, were significantly correlated (0.77 – 0.95, p < 0.05). Similarly, a strong positive correlation (0.67 – 0.91, p < 0.05) was evident between the abundances of bio-markers BacH and F-RNA-II, and the concentrations of the conservative markers, trimethoprim, meprobamate, diltiazem, triclocarban, metformin, sucralose, gemfibrozil, sulfamethoxazole, and carbamazepine. Human mitochondrial DNA (MitoH) correlated moderately with labile markers nicotine and salicylic acid as well as with conservative markers metformin and triclocarban (0.31 – 0.47, p<0.05). This study showed that by associating chemical and biological markers, a robust technique was developed for fingerprinting source-specific untreated waste and fecal contamination in source waters. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anthropogenic%20markers" title="anthropogenic markers">anthropogenic markers</a>, <a href="https://publications.waset.org/abstracts/search?q=bacteroidales" title=" bacteroidales"> bacteroidales</a>, <a href="https://publications.waset.org/abstracts/search?q=fecal%20pollution" title=" fecal pollution"> fecal pollution</a>, <a href="https://publications.waset.org/abstracts/search?q=source%20waters" title=" source waters"> source waters</a>, <a href="https://publications.waset.org/abstracts/search?q=wastewater" title=" wastewater"> wastewater</a> </p> <a href="https://publications.waset.org/abstracts/192663/the-simultaneous-application-of-chemical-and-biological-markers-to-identify-reliable-indicators-of-untreated-human-waste-and-fecal-pollution-in-urban-philadelphia-source-waters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192663.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">15</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1470</span> Anticancer Potentials of Aqueous Tinospora cordifolia and Its Bioactive Polysaccharide, Arabinogalactan on Benzo(a)Pyrene Induced Pulmonary Tumorigenesis: A Study with Relevance to Blood Based Biomarkers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vandana%20Mohan">Vandana Mohan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashwani%20%20Koul"> Ashwani Koul</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: To evaluate the potential of Aqueous Tinospora cordifolia stem extract (Aq.Tc) and Arabinogalactan (AG) on pulmonary carcinogenesis and associated tumor markers. Background: Lung cancer is one of the most frequent malignancy with high mortality rate due to limitation of early detection resulting in low cure rates. Current research effort focuses on identifying some blood-based biomarkers like CEA, ctDNA and LDH which may have potential to detect cancer at an early stage, evaluation of therapeutic response and its recurrence. Medicinal plants and their active components have been widely investigated for their anticancer potentials. Aqueous preparation of T. Cordifolia extract is enriched in the polysaccharide fraction i.e., AG when compared with other types of extract. Moreover, reports are available of polysaccharide fraction of T. Cordifolia in in vitro lung cancer models which showed profound anti-metastatic activity against these cell lines. However, not much has been explored about its effect in in vivo lung cancer models and the underlying mechanism involved. Experimental Design: Mice were randomly segregated into six groups. Group I animals served as control. Group II animals were administered with Aq. Tc extract (200 mg/kg b.w.) p.o.on the alternate days. Group III animals were fed with AG (7.5 mg/kg b.w.) p.o. on the alternate days (thrice a week). Group IV animals were installed with Benzo(a)pyrene (50 mg/kg b.w.), i.p. twice within an interval of two weeks. Group V animals received Aq. Tc extract as in group II along with it B(a)P was installed after two weeks of Aq. Tc administration following the same protocol as for group IV. Group VI animals received AG as in group III along with it B(a)P was installed after two weeks of AG administration. Results: Administration of B(a)P to mice resulted in increased tumor incidence, multiplicity and pulmonary somatic index with concomitant increase in serum/plasma markers like CEA, ctDNA, LDH and TNF-α.Aq.Tc and AG supplementation significantly attenuated these alterations at different stages of tumorigenesis thereby showing potent anti-cancer effect in lung cancer. A pronounced decrease in serum/plasma markers were observed in animals treated with Aq.Tc as compared to those fed with AG. Also, extensive hyperproliferation of alveolar epithelium was prominent in B(a)P induced lung tumors. However, treatment of Aq.Tc and AG to lung tumor bearing mice exhibited reduced alveolar damage evident from decreased number of hyperchromatic irregular nuclei. A direct correlation between the concentration of tumor markers and the intensity of lung cancer was observed in animals bearing cancer co-treated with Aq.Tc and AG. Conclusion: These findings substantiate the chemopreventive potential of Aq.Tc and AG against lung tumorigenesis. Interestingly, Aq.Tc was found to be more effective in modulating the cancer as reflected by various observations which may be attributed to the synergism offered by various components of Aq.Tc. Further studies are in progress to understand the underlined mechanism in inhibiting lung tumorigenesis by Aq.Tc and AG. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arabinogalactan" title="Arabinogalactan">Arabinogalactan</a>, <a href="https://publications.waset.org/abstracts/search?q=Benzo%28a%29pyrene%20B%28a%29P" title=" Benzo(a)pyrene B(a)P"> Benzo(a)pyrene B(a)P</a>, <a href="https://publications.waset.org/abstracts/search?q=carcinoembryonic%20antigen%20%28CEA%29" title=" carcinoembryonic antigen (CEA)"> carcinoembryonic antigen (CEA)</a>, <a href="https://publications.waset.org/abstracts/search?q=circulating%20tumor%20DNA%20%28ctDNA%29" title=" circulating tumor DNA (ctDNA)"> circulating tumor DNA (ctDNA)</a>, <a href="https://publications.waset.org/abstracts/search?q=lactate%20dehydrogenase%20%28LDH%29" title=" lactate dehydrogenase (LDH)"> lactate dehydrogenase (LDH)</a>, <a href="https://publications.waset.org/abstracts/search?q=Tinospora%20cordifolia" title=" Tinospora cordifolia"> Tinospora cordifolia</a> </p> <a href="https://publications.waset.org/abstracts/76805/anticancer-potentials-of-aqueous-tinospora-cordifolia-and-its-bioactive-polysaccharide-arabinogalactan-on-benzoapyrene-induced-pulmonary-tumorigenesis-a-study-with-relevance-to-blood-based-biomarkers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76805.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">185</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1469</span> A Contrastive Rhetoric Study: The Use of Textual and Interpersonal Metadiscoursal Markers in Persian and English Newspaper Editorials</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Habibollah%20Mashhady">Habibollah Mashhady</a>, <a href="https://publications.waset.org/abstracts/search?q=Moslem%20Fatollahi"> Moslem Fatollahi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study tries to contrast the use of metadiscoursal markers in English and Persian Newspaper Editorials as persuasive text types. These markers are linguistic elements in the text which do not add to the propositional content of it, rather they serve to realize the Halliday’s (1985) textual and interpersonal functions of language. At first, some of the most common markers from five subcategories of Text Connectives, Illocution Markers, Hedges, Emphatics, and Attitude Markers were identified in both English and Persian newspapers. Then, the frequency of occurrence of these markers in both English and Persian corpus consisting of 44 randomly selected editorials (18,000 words in each) from several English and Persian newspapers was recorded. After that, using a two-way chi square analysis, the overall x2 obs was found to be highly significant. So, the null hypothesis of no difference was confidently rejected. Finally, in order to determine the contribution of each subcategory to the overall x 2 value, one-way chi square analyses were applied to the individual subcategories. The results indicated that only two of the five subcategories of markers were statistically significant. This difference is then attributed to the differing spirits prevailing in the linguistic communities involved. Regarding the minor research question it was found that, in contrast to English writers, Persian writers are more writer-oriented in their writings. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=metadiscoursal%20markers" title="metadiscoursal markers">metadiscoursal markers</a>, <a href="https://publications.waset.org/abstracts/search?q=textual%20meta-function" title=" textual meta-function"> textual meta-function</a>, <a href="https://publications.waset.org/abstracts/search?q=interpersonal%20meta-function" title=" interpersonal meta-function"> interpersonal meta-function</a>, <a href="https://publications.waset.org/abstracts/search?q=persuasive%20texts" title=" persuasive texts"> persuasive texts</a>, <a href="https://publications.waset.org/abstracts/search?q=English%20and%20Persian%20newspaper%20editorials" title=" English and Persian newspaper editorials"> English and Persian newspaper editorials</a> </p> <a href="https://publications.waset.org/abstracts/18633/a-contrastive-rhetoric-study-the-use-of-textual-and-interpersonal-metadiscoursal-markers-in-persian-and-english-newspaper-editorials" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18633.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">574</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1468</span> Recent Advancement in Dendrimer Based Nanotechnology for the Treatment of Brain Tumor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nitin%20Dwivedi">Nitin Dwivedi</a>, <a href="https://publications.waset.org/abstracts/search?q=Jigna%20Shah"> Jigna Shah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Brain tumor is metastatic neoplasm of central nervous system, in most of cases it is life threatening disease with low survival rate. Despite of enormous efforts in the development of therapeutics and diagnostic tools, the treatment of brain tumors and gliomas remain a considerable challenge in the area of neuro-oncology. The most reason behind of this the presence of physiological barriers including blood brain barrier and blood brain tumor barrier, lead to insufficient reach ability of therapeutic agents at the site of tumor, result of inadequate destruction of gliomas. So there is an indeed need empowerment of brain tumor imaging for better characterization and delineation of tumors, visualization of malignant tissue during surgery, and tracking of response to chemotherapy and radiotherapy. Multifunctional different generations of dendrimer offer an improved effort for potentiate drug delivery at the site of brain tumor and gliomas. So this article emphasizes the innovative dendrimer approaches in tumor targeting, tumor imaging and delivery of therapeutic agent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blood%20brain%20barrier" title="blood brain barrier">blood brain barrier</a>, <a href="https://publications.waset.org/abstracts/search?q=dendrimer" title=" dendrimer"> dendrimer</a>, <a href="https://publications.waset.org/abstracts/search?q=gliomas" title=" gliomas"> gliomas</a>, <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title=" nanotechnology"> nanotechnology</a> </p> <a href="https://publications.waset.org/abstracts/30047/recent-advancement-in-dendrimer-based-nanotechnology-for-the-treatment-of-brain-tumor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30047.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">561</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1467</span> Computer Aided Diagnostic System for Detection and Classification of a Brain Tumor through MRI Using Level Set Based Segmentation Technique and ANN Classifier</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Atanu%20K%20Samanta">Atanu K Samanta</a>, <a href="https://publications.waset.org/abstracts/search?q=Asim%20Ali%20Khan"> Asim Ali Khan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Due to the acquisition of huge amounts of brain tumor magnetic resonance images (MRI) in clinics, it is very difficult for radiologists to manually interpret and segment these images within a reasonable span of time. Computer-aided diagnosis (CAD) systems can enhance the diagnostic capabilities of radiologists and reduce the time required for accurate diagnosis. An intelligent computer-aided technique for automatic detection of a brain tumor through MRI is presented in this paper. The technique uses the following computational methods; the Level Set for segmentation of a brain tumor from other brain parts, extraction of features from this segmented tumor portion using gray level co-occurrence Matrix (GLCM), and the Artificial Neural Network (ANN) to classify brain tumor images according to their respective types. The entire work is carried out on 50 images having five types of brain tumor. The overall classification accuracy using this method is found to be 98% which is significantly good. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=brain%20tumor" title="brain tumor">brain tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=computer-aided%20diagnostic%20%28CAD%29%20system" title=" computer-aided diagnostic (CAD) system"> computer-aided diagnostic (CAD) system</a>, <a href="https://publications.waset.org/abstracts/search?q=gray-level%20co-occurrence%20matrix%20%28GLCM%29" title=" gray-level co-occurrence matrix (GLCM)"> gray-level co-occurrence matrix (GLCM)</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20segmentation" title=" tumor segmentation"> tumor segmentation</a>, <a href="https://publications.waset.org/abstracts/search?q=level%20set%20method" title=" level set method"> level set method</a> </p> <a href="https://publications.waset.org/abstracts/61237/computer-aided-diagnostic-system-for-detection-and-classification-of-a-brain-tumor-through-mri-using-level-set-based-segmentation-technique-and-ann-classifier" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61237.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">512</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1466</span> U11 Functionalised Luminescent Gold Nanoclusters for Pancreatic Tumor Cells Labelling</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Regina%20M.%20Chiechio">Regina M. Chiechio</a>, <a href="https://publications.waset.org/abstracts/search?q=R%C3%A9mi%20Leguev%C3%A9l"> Rémi Leguevél</a>, <a href="https://publications.waset.org/abstracts/search?q=Helene%20Solhi"> Helene Solhi</a>, <a href="https://publications.waset.org/abstracts/search?q=Marie%20Madeleine%20Gueguen"> Marie Madeleine Gueguen</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephanie%20Dutertre"> Stephanie Dutertre</a>, <a href="https://publications.waset.org/abstracts/search?q=Xavier"> Xavier</a>, <a href="https://publications.waset.org/abstracts/search?q=Jean-Pierre%20Bazureau"> Jean-Pierre Bazureau</a>, <a href="https://publications.waset.org/abstracts/search?q=Olivier%20Mignen"> Olivier Mignen</a>, <a href="https://publications.waset.org/abstracts/search?q=Pascale%20Even-Hernandez"> Pascale Even-Hernandez</a>, <a href="https://publications.waset.org/abstracts/search?q=Paolo%20Musumeci"> Paolo Musumeci</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Jose%20Lo%20Faro"> Maria Jose Lo Faro</a>, <a href="https://publications.waset.org/abstracts/search?q=Valerie%20Marchi"> Valerie Marchi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Thanks to their ultra-small size, high electron density, and low toxicity, gold nanoclusters (Au NCs) have unique photoelectrochemical and luminescence properties that make them very interesting for diagnosis bio-imaging and theranostics. These applications require control of their delivery and interaction with cells; for this reason, the surface chemistry of Au NCs is essential to determine their interaction with the targeted biological objects. Here we demonstrate their ability as markers of pancreatic tumor cells. By functionalizing the surface of the NCs with a recognition peptite (U11), the nanostructures are able to preferentially bind to pancreatic cancer cells via a receptor (uPAR) overexpressed by these cells. Furthermore, the NCs can mark even the nucleus without the need of fixing the cells. These nanostructures can therefore be used as a non-toxic, multivalent luminescent platform, capable of selectively recognizing tumor cells for bioimaging, drug delivery, and radiosensitization. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gold%20nanoclusters" title="gold nanoclusters">gold nanoclusters</a>, <a href="https://publications.waset.org/abstracts/search?q=luminescence" title=" luminescence"> luminescence</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarkers" title=" biomarkers"> biomarkers</a>, <a href="https://publications.waset.org/abstracts/search?q=pancreatic%20cancer" title=" pancreatic cancer"> pancreatic cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=biomedical%20applications" title=" biomedical applications"> biomedical applications</a>, <a href="https://publications.waset.org/abstracts/search?q=bioimaging" title=" bioimaging"> bioimaging</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorescent%20probes" title=" fluorescent probes"> fluorescent probes</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a> </p> <a href="https://publications.waset.org/abstracts/146031/u11-functionalised-luminescent-gold-nanoclusters-for-pancreatic-tumor-cells-labelling" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146031.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1465</span> Mage Fusion Based Eye Tumor Detection</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20Ashit">Ahmed Ashit</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Image fusion is a significant and efficient image processing method used for detecting different types of tumors. This method has been used as an effective combination technique for obtaining high quality images that combine anatomy and physiology of an organ. It is the main key in the huge biomedical machines for diagnosing cancer such as PET-CT machine. This thesis aims to develop an image analysis system for the detection of the eye tumor. Different image processing methods are used to extract the tumor and then mark it on the original image. The images are first smoothed using median filtering. The background of the image is subtracted, to be then added to the original, results in a brighter area of interest or tumor area. The images are adjusted in order to increase the intensity of their pixels which lead to clearer and brighter images. once the images are enhanced, the edges of the images are detected using canny operators results in a segmented image comprises only of the pupil and the tumor for the abnormal images, and the pupil only for the normal images that have no tumor. The images of normal and abnormal images are collected from two sources: “Miles Research” and “Eye Cancer”. The computerized experimental results show that the developed image fusion based eye tumor detection system is capable of detecting the eye tumor and segment it to be superimposed on the original image. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=image%20fusion" title="image fusion">image fusion</a>, <a href="https://publications.waset.org/abstracts/search?q=eye%20tumor" title=" eye tumor"> eye tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=canny%20operators" title=" canny operators"> canny operators</a>, <a href="https://publications.waset.org/abstracts/search?q=superimposed" title=" superimposed"> superimposed</a> </p> <a href="https://publications.waset.org/abstracts/30750/mage-fusion-based-eye-tumor-detection" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30750.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">363</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1464</span> Effects of Aerobic Training on MicroRNA Let-7a Expression and Levels of Tumor Tissue IL-6 in Mice With Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Leila%20Anoosheh">Leila Anoosheh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: The aim of this study was to assess The effects of aerobic training on microRNA let-7a expression and levels of tumor tissue IL-6 in mice with breast cancer. Method: Twenty BALB/c c mice (4-5 weeks,17 gr mass) were cancerous by injection of estrogen-dependent receptor breast cancer cells MC4-L2 and divided into two groups: tumor-training(TT) and tumor-control(TC) group. Then TT group completed aerobic training for 6 weeks, 5 days per week (14-18 m/min). After tumor emersion, tumor width and length were measured by digital caliper every week. 48 hours after the last exercise subjects were killed. Tissue sampling were collected and stored in -70ᵒ. Tumor tissue was homogenized and let-7a expression and IL-6 levels were accounted with Real time-PCR and ELISA Kit respectively. Statistical analysis of let-7a was conducted by the REST software. Repeated measures and independent tests were used to assess tumor size and IL-6, respectively. Results: Tumor size and IL-6 levels were significantly decreased in TT group compare with TC group (p<0.05). microRNA let-7a was increased significantly in TT against control group respectively (p=0/000). Conclusion: Reduction in tumor size, followed by aerobic exercise can be attributed to the loss of inflammatory factors such as IL-6; It seems that regarding to up regulation effects of aerobic exercise training on let-7a and down regulation effects of that on IL-6 in mice with breast cancer, This type of training can be used as adjuvant therapy in conjunction with other therapies for breast cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=aerobic%20training" title=" aerobic training"> aerobic training</a>, <a href="https://publications.waset.org/abstracts/search?q=microRNA%20%20let-7a" title=" microRNA let-7a"> microRNA let-7a</a>, <a href="https://publications.waset.org/abstracts/search?q=IL-6" title=" IL-6"> IL-6</a> </p> <a href="https://publications.waset.org/abstracts/16519/effects-of-aerobic-training-on-microrna-let-7a-expression-and-levels-of-tumor-tissue-il-6-in-mice-with-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16519.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">432</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1463</span> An Insight into Early Stage Detection of Malignant Tumor by Microwave Imaging </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Hassan%20Khalil">Muhammad Hassan Khalil</a>, <a href="https://publications.waset.org/abstracts/search?q=Xu%20Jiadong"> Xu Jiadong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Detection of malignant tumor inside the breast of women is a challenging field for the researchers. MWI (Microwave imaging) for breast cancer diagnosis has been of interest for last two decades, newly it suggested for finding cancerous tissues of women breast. A simple and basic idea of the mathematical modeling is used throughout this paper for imaging of malignant tumor. In this paper, the authors explained inverse scattering method in the microwave imaging and also present some simulation results. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer%20detection" title="breast cancer detection">breast cancer detection</a>, <a href="https://publications.waset.org/abstracts/search?q=microwave%20imaging" title=" microwave imaging"> microwave imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=tomography" title=" tomography"> tomography</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor" title=" tumor"> tumor</a> </p> <a href="https://publications.waset.org/abstracts/2718/an-insight-into-early-stage-detection-of-malignant-tumor-by-microwave-imaging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2718.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">411</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1462</span> Formulation and Anticancer Evaluation of Beta-Sitosterol in Henna Methanolic Extract Embedded in Controlled Release Nanocomposite</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanjukta%20Badhai">Sanjukta Badhai</a>, <a href="https://publications.waset.org/abstracts/search?q=Durga%20Barik"> Durga Barik</a>, <a href="https://publications.waset.org/abstracts/search?q=Bairagi%20C.%20Mallick"> Bairagi C. Mallick</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, Beta-Sitosterol in Lawsonia methanolic leaf extract embedded in controlled release nanocomposite was prepared and evaluated for in vivo anticancer efficacy in dimethyl hydrazine (DMH) induced colon cancer. In the present study, colon cancer was induced by s.c injection of DMH (20 mg/kg b.wt) for 15 weeks. The animals were divided into five groups as follows control, DMH alone, DMH and Beta Sitosterol nanocomposite (50mg/kg), DMH and Beta Sitosterol nanocomposite (100 mg/kg) and DMH and Standard Silymarin (100mg/kg) and the treatment was carried out for 15 weeks. At the end of the study period, the blood was withdrawn, and serum was separated for haematological, biochemical analysis and tumor markers. Further, the colonic tissue was removed for the estimation of antioxidants and histopathological analysis. The results of the study displays that DMH intoxication elicits altered haematological parameters (RBC,WBC, and Hb), elevated lipid peroxidation and decreased antioxidants level (SOD, CAT, GPX, GST and GSH), elevated lipid profiles (cholesterol and triglycerides), tumor markers (CEA and AFP) and altered colonic tissue histology. Meanwhile, treatment with Beta Sitosterol nanocomposites significantly restored the altered biochemicals parameters in DMH induced colon cancer mediated by its anticancer efficacy. Further, Beta Sitosterol nanocomposite (100 mg/kg) showed marked efficacy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanocomposites" title="nanocomposites">nanocomposites</a>, <a href="https://publications.waset.org/abstracts/search?q=herbal%20formulation" title=" herbal formulation"> herbal formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=henna" title=" henna"> henna</a>, <a href="https://publications.waset.org/abstracts/search?q=beta%20sitosterol" title=" beta sitosterol"> beta sitosterol</a>, <a href="https://publications.waset.org/abstracts/search?q=colon%20cancer" title=" colon cancer"> colon cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=dimethyl%20hydrazine" title=" dimethyl hydrazine"> dimethyl hydrazine</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=lipid%20peroxidation" title=" lipid peroxidation"> lipid peroxidation</a> </p> <a href="https://publications.waset.org/abstracts/84194/formulation-and-anticancer-evaluation-of-beta-sitosterol-in-henna-methanolic-extract-embedded-in-controlled-release-nanocomposite" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84194.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">163</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1461</span> Metastatic Ovarian Tumor Discovered Accidentally during Cesarean Section in a 34 Year Old Woman: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghada%20E.%20Esheba">Ghada E. Esheba</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghufran%20Kheshaifaty"> Ghufran Kheshaifaty</a>, <a href="https://publications.waset.org/abstracts/search?q=Kholoud%20%20Al-Harbi"> Kholoud Al-Harbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Wafa%27a%20Al-Harbi"> Wafa'a Al-Harbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ala%27a%20Al-Orabi"> Ala'a Al-Orabi</a>, <a href="https://publications.waset.org/abstracts/search?q=Moayad%20Turkistani"> Moayad Turkistani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Krukenberg tumor is a rare metastatic ovarian carcinoma that usually occurs in female between 30 - 40 year old and rarely seen after menopause. Stomach is the most common primary site. Histopathological features of krukenberg tumors appear as diffuse stromal proliferation, mucus-production, and numerous signet-cells and these tumors spread mostly by lymphatic route. Treatment and prognostic factors are not well established. This study describes a 34 year old female with a unilateral ovarian mass discovered accidentally during cesarean section delivery and it was misdiagnosed as luteoma of pregnancy, but histopathological examination showed a diffuse infiltration of the ovary and omentum by signet ring cells. These findings were not correlated with luteoma of pregnancy or any other types of primary ovarian tumors like surface epithelial tumor, sex cord stromal tumor or germ cell tumor. However, after the analysis of immunohistochemical results (negative CK7, positive CK20 and CDX-2), the finding was the diagnostic of metastatic krukenberg tumor. Two weeks later, the patient was evaluated and a large gastric tumor was found in her stomach and she underwent gastrectomy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CK7" title="CK7">CK7</a>, <a href="https://publications.waset.org/abstracts/search?q=CK20" title=" CK20"> CK20</a>, <a href="https://publications.waset.org/abstracts/search?q=CDX-2" title=" CDX-2"> CDX-2</a>, <a href="https://publications.waset.org/abstracts/search?q=Krukenburg%20tumor" title=" Krukenburg tumor"> Krukenburg tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=metastatic%20ovarian%20tumor" title=" metastatic ovarian tumor"> metastatic ovarian tumor</a> </p> <a href="https://publications.waset.org/abstracts/59354/metastatic-ovarian-tumor-discovered-accidentally-during-cesarean-section-in-a-34-year-old-woman-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59354.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">315</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=tumor%20markers&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=tumor%20markers&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=tumor%20markers&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=tumor%20markers&page=5">5</a></li> <li class="page-item"><a class="page-link" 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