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Research — Laboratory of Intensive Care Medicine

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data-portal-url="https://gbiomed.kuleuven.be" data-i18ncatalogurl="https://gbiomed.kuleuven.be/plonejsi18n" data-pat-pickadate="{&quot;date&quot;: {&quot;selectYears&quot;: 200}, &quot;time&quot;: {&quot;interval&quot;: 5 } }" data-pat-plone-modal="{&quot;actionOptions&quot;: {&quot;displayInModal&quot;: false}}"><section id="edit-bar" role="toolbar"></section><div class="l-page"> <!-- GLOBAL HEADER --> <nav class="global-header noindex hidden-print"> <div class="container"> <a class="navbar-brand" href="https://www.kuleuven.be/english/"><img class="logo" alt="logo" src="https://stijl.kuleuven.be/releases/latest/img/svg/logo.svg" width="157" height="56" /></a> <div class="controls"> <a class="btn btn-ext btn-home" href="https://www.kuleuven.be/english/">KU Leuven Home</a> <a href="#" class="btn-toggle js-flyout-toggle flyout-toggle collapsed" role="button" aria-expanded="false" aria-controls="flyout-local-menu" data-toggle="collapse" data-target="#flyout-local-menu"><span class="lines"></span></a> </div> </div> </nav> <!-- END GLOBAL HEADER --> <!-- LOCAL HEADER --> <nav class="local-header"> <div class="container container-relative"> <nav class="nav-header"> <h2> <a href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine"> Laboratory of Intensive Care Medicine </a> <a href="#" class="btn-toggle hidden-lg-up" role="button" aria-expanded="false" data-toggle="collapse" data-target="#local-header" aria-controls="local-header"><span class="lines"></span></a> </h2> </nav> <nav class="nav-tabs nav-more collapse" id="local-header"> <ul id="portal-globalnav"><li><a href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/research">Research</a></li><li><a href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/group-members">Group members</a></li><li><a href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/phd-projects">Students</a></li><li><a href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/study-protocols">Study Protocols</a></li><li><a href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/funding-history">Funding history</a></li><li><a href="https://www.uzleuven.be/nl/intensieve-geneeskunde">Intensive Care Unit Hospital</a></li></ul> </nav> </div> </nav> <!-- END LOCAL HEADER --> <div class="kuleuven-banner"></div> <!-- MAIN CONTENT--> <div role="main"> <div class="container"> <div class="row"> <aside id="global_statusmessage"> <div> </div> </aside> </div> <div class="row"> <!-- Breadcrumbs--> <div id="above-content" class="col-xs-12"> <nav id="portal-breadcrumbs" aria-label="breadcrumb"> <div class="container"> <ol class="breadcrumb"> <li class="breadcrumb-item"><a href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine">Home</a></li> <li class="breadcrumb-item active" aria-current="page">Research</li> </ol> </div> </nav> </div> <div class="col-xs-12 col-sm-12"> <!-- <p class="pull-right visible-xs"> <button type="button" class="btn btn-primary btn-xs" data-toggle="offcanvas">Toggle nav</button> </p> --> <div class="row"> <div class="col-xs-12 col-sm-12"> <article id="content"> <header> <div id="viewlet-above-content-title"><span id="social-tags-body" itemscope="" itemtype="http://schema.org/WebPage" style="display: none"> <span itemprop="name">Research</span> <span itemprop="description"></span> <span itemprop="url">https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/research</span> <span itemprop="image">https://gbiomed.kuleuven.be/++resource++plone-logo.svg</span> </span> </div> <h1>Research</h1> <div id="viewlet-below-content-title"></div> <!-- template when behavior is enabled and the CT has the show_desc field --> <!-- template when behavior is not enabled and the CT deosn't have the show_desc field which is the same as the default template of plone for description --> <div id="viewlet-below-content-description"></div> </header> <div id="viewlet-above-content-body"> </div> <div id="content-core"> <section id="section-text"> <div data-pat-autotoc="prependTo:#autotoc-container;levels:h1,h2,h3,h4" class="" id="parent-fieldname-text"><div class="kul-card-color card card-primary"> <div class="card-body"> <p>Critical Care Medicine started with the 1950s polio epidemics in Scandinavia and the construction of the iron lung. This young medical specialty has evolved, over only a few decades, into a high-tech branch of medicine that uses sophisticated mechanical devices to support the function of vital organs and a wide array of powerful drugs and monitoring systems, allowing patients to survive a variety of previously lethal insults such as multiple trauma, extensive surgery or severe illness. The initial re<picture><source></source><img alt="" class="left image-inline image-richtext picture-variant-small" height="150" src="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/images/patienten.jpg/@@images/image-400-e2e106e3f58eb009da2b64b7a0804168.jpeg" title="patienten" width="400" /></picture>asons for admission to the intensive care unit (ICU) vary but have in common that they all evoke cell damage, via hypoperfusion, hypoxia, excessive inflammation or metabolic insults. Approximately 30% of patients who survive the initial shock phase of their lethal insult continue to remain dependent upon intensive care medicine for a longer time, hereby entering a chronic phase of critical illness. Despite best efforts, mortality among such patients, who require intensive care for more than a few days, has remained around 20% worldwide. For the majority of patients who do not survive after extended critical care dependency, the cause of death is therapy-resistant, non-resolving multiple organ failure and weakness. The exact pathophysiology of this condition, which affects millions of patients each year worldwide and consumes a large fraction of health care resources, remains incompletely understood.</p> <p>Our overall research objective is to unravel key pathways underlying critical illness-induced organ failure, thereby identifying potential therapeutic targets to enhance recovery. We focus on endocrine and metabolic underlying mechanisms of organ-specific problems evoked by critical illness.</p> <hr /></div> </div> <div class="row"> <div class="col-xs-12 col-md-4"> <div class="kul-card-image card card-gray"> <div class="card-body"> <h2>Endocrine response to stress</h2> <p>The first contribution by our research group has been to introduce, by carefully designed studies in acute and prolonged critically ill patients and animal models, the distinction between the initial acute stress response...</p> <p><a class="btn btn-primary" href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/researcharticles/endocrine-response-to-stress">Read more</a></p> </div> </div> </div> <div class="col-xs-12 col-md-4"> <div class="kul-card-image card card-gray"> <div class="card-body"> <h2>Glucose toxicity</h2> <p>The second focus of our research group comprised the research on the so-called “diabetes of injury”. Hyperglycemia and insulin resistance are common in patients with critical illness, even when glucose homeostasis was previously normal...</p> <p><a class="btn btn-primary" href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/researcharticles/glucose-toxicity">Read more</a></p> </div> </div> </div> <div class="col-xs-12 col-md-4"> <div class="kul-card-image card card-gray"> <div class="card-body"> <h2>Nutrients and autophagy</h2> <p>While studying human tissue biopsies from ICU patients, the group had discovered that one of the most key cellular pathways for damage removal, autophagy, appears to fail during critical illness...</p> <p><a class="btn btn-primary" href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/researcharticles/nutrients-and-autophagy">Read more</a></p> </div> </div> </div> </div> <div class="row"> <div class="col-xs-12 col-md-4"> <div class="kul-card-image card card-gray"> <div class="card-body"> <h2>Data mining</h2> <p>Detailed clinical data obtained during or outside the time window of the large clinical studies continuously feed a new field with applications for computerized data management and machine learning to predict patient outcome...</p> <p><a class="btn btn-primary" href="https://gbiomed.kuleuven.be/english/research/50000618/laboratory-of-intensive-care-medicine/researcharticles/data-mining">Read more</a></p> </div> </div> </div> </div> <p> </p> </div> </section> </div> <div id="viewlet-below-content-body"> </div> <footer> <div id="viewlet-below-content"> </div> </footer> </article> </div> </div> </div> <!-- rechterbalk - nieuws --> <div id="nieuws" class="col-xs-12 col-md-4 col-block"></div> <!-- These divs re-add the portlets, but also doubles the main content--> <!-- Behavior/Rules stated in backend.xml & rules.xml --> <!-- Commented out for now: not focussing on portlets --> <!-- <div id="content-container"> --> <!-- main content (box2 and 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