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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-08-08T21:42:57.897">August 8, 2024</time></div><h1 class="text-[26px] font-medium leading-8">Late-Stage Vibostolimab, Pembrolizumab Plus Chemotherapy Trial Discontinued Due to Adverse Events</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="Late-Stage Vibostolimab, Pembrolizumab Plus Chemotherapy Trial Discontinued Due to Adverse Events" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" 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viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#7f7f7f"></circle><path d="M17,22v20h30V22H17z M41.1,25L32,32.1L22.9,25H41.1z M20,39V26.6l12,9.3l12-9.3V39H20z" fill="white"></path></svg></button><a class="print-wrap flex justify-center items-center cursor-pointer"><svg id="print" xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="currentColor" class="print bi bi-printer" viewBox="0 0 16 16"> <path d="M2.5 8a.5.5 0 1 0 0-1 .5.5 0 0 0 0 1z"></path> <path d="M5 1a2 2 0 0 0-2 2v2H2a2 2 0 0 0-2 2v3a2 2 0 0 0 2 2h1v1a2 2 0 0 0 2 2h6a2 2 0 0 0 2-2v-1h1a2 2 0 0 0 2-2V7a2 2 0 0 0-2-2h-1V3a2 2 0 0 0-2-2H5zM4 3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1v2H4V3zm1 5a2 2 0 0 0-2 2v1H2a1 1 0 0 1-1-1V7a1 1 0 0 1 1-1h12a1 1 0 0 1 1 1v3a1 1 0 0 1-1 1h-1v-1a2 2 0 0 0-2-2H5zm7 2v3a1 1 0 0 1-1 1H5a1 1 0 0 1-1-1v-3a1 1 0 0 1 1-1h6a1 1 0 0 1 1 1z"></path></svg></a></div><style> .print-wrap { width: 32px; height: 32px; background: #7F7F7F; border-radius: 100%; } .print { background: #7F7F7F; color: white; padding: 2px; border-radius: 100%; } </style></div></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><p class="py-2 mb-2 text-sm italic text-gray-600">A high number of adverse events were reported in a late-stage trial conducted by Merck for treatment in lung cancer.</p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">Merck announced today that it would be discontinuing its late-stage trial for vibostolimab/pembrolizumab plus chemotherapy for patients with extensive-stage <a target="_blank" href="https://www.ajmc.com/compendium/lung-cancer">small cell lung cancer</a> (ES-SCLC).<sup class="text-inherit">1</sup> The anti–PD-1 therapy was being compared with atezolizumab in combination with chemotherapy in the KeyVibe-008 trial (<a rel="nofollow noreferrer noopener" target="_blank" href="https://clinicaltrials.gov/study/NCT05224141">NCT05224141</a>). However, patients on vibostolimab/pembrolizumab had a higher rate of adverse events (AEs) and immune-related AEs compared with the control arm, leading to its discontinuation.</p><p class="pb-2"></p><p class="pb-2">Vibostolimab is one of several immunotherapies defined as anti-TIGIT. This new class of immunotherapies has been popular for drugmakers, as it has the potential to change how cancer is treated. However, the few trials in the space have been less successful. Anti-TIGIT drugs work by binding themselves to TIGIT, which is a receptor on immune cells.<sup class="text-inherit">2</sup> The drug then helps to activate the immune system against cancer cells while preventing an immune attack against healthy cells.</p><div class=""><div style="width:40%;float:right;max-width:525px;margin:0 0 1.5rem 1.5rem;clear:both;cursor:" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%275000%27%20height=%273750%27/%3e"/></span><img alt="The combination of vibostolimab and pembrolizumab proved to be unsafe in patients with small cell lung cancer | Image credit: Sebastian Kaulitzki - stock.adobe.com" title="The combination of vibostolimab and pembrolizumab proved to be unsafe in patients with small cell lung cancer | Image credit: Sebastian Kaulitzki - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="The combination of vibostolimab and pembrolizumab proved to be unsafe in patients with small cell lung cancer | Image credit: Sebastian Kaulitzki - stock.adobe.com" title="The combination of vibostolimab and pembrolizumab proved to be unsafe in patients with small cell lung cancer | Image credit: Sebastian Kaulitzki - stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F46ed1f28dea92f2cb13e14b5856c7258caea556e-5000x3750.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 1x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F46ed1f28dea92f2cb13e14b5856c7258caea556e-5000x3750.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2">The combination of vibostolimab and pembrolizumab proved to be unsafe in patients with small cell lung cancer | Image credit: Sebastian Kaulitzki - stock.adobe.com</p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/46ed1f28dea92f2cb13e14b5856c7258caea556e-5000x3750.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">In previous tests, this combination failed to slow disease progression in patients with lung cancer who had not responded to other treatments and in patients with severe skin cancer. All participants in the study will immediately cease use of the treatment immediately.</p><p class="pb-2"></p><p class="pb-2">The trial was a randomized, double-blind study<sup class="text-inherit">3</sup> that enrolled patients who were 18 years and older with confirmed stage IV ES-SCLC. All participants needed to have a predicted life expectancy of at least 3 months. Patients were excluded if they had poor medical risk, had prior treatment for SCLC, had a live or live-attenuated vaccine within 30 days of the study, and had a history of noninfectious pneumonitis interstitial lung disease, among other exclusion criteria.</p><p class="pb-2"></p><p class="pb-2">All participants in the experimental group received 200 mg of vibostolimab and 200 mg of pembrolizumab, plus etoposide and platinum chemotherapy once every 3 weeks for 4 cycles. The other group received 1200 mg of atezolizumab in combination with etoposide and platinum chemotherapy once every 3 weeks for 4 cycles before transitioning to atezolizumab by itself. Participants were allowed to stay in the trial until they met grounds for discontinuation.</p><p class="pb-2"></p><p class="pb-2">This cancellation calls into question other ongoing studies involving anti-TIGIT therapies, including the phase 3 studies KeyVibe-003 (<a rel="nofollow noreferrer noopener" target="_blank" href="https://clinicaltrials.gov/study/NCT04738487">NCT04738487</a>), KeyVibe-006 (<a rel="nofollow noreferrer noopener" target="_blank" href="https://clinicaltrials.gov/study/NCT0529842">NCT0529842</a>), and KeyVibe-007 (<a rel="nofollow noreferrer noopener" target="_blank" href="https://clinicaltrials.gov/study/NCT05226598">NCT05226598</a>). Although several companies, such as Gilead Sciences and GSK, are looking into vibostolimab and pembrolizumab as the future of treatment in lung cancer, no previous study has seen any improvement in progression-free or overall survival, and others, such as the KeyVibe-010 trial, have been discontinued. KeyVibe-003 and KeyVibe-006 are both looking into non–small cell lung cancers (NSCLCs) to assess efficacy in that subgroup. These trials are scheduled for completion in 2026, so it remains unknown what the efficacy of either treatment will be.</p><p class="pb-2"></p><p class="pb-2">Although past clinical trials have seen lackluster results, it’s worth looking forward to the results of the clinical trials on the way, as a breakthrough on these treatments could spell a new direction in lung cancer treatment, especially in NSCLC. However, this discontinuation does throw another blow to the use of these therapies in the future.</p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. Merck provides update on phase 3 KeyVibe-008 trial evaluating an investigational fixed-dose combination of vibostolimab and pembrolizumab in patients with extensive-stage small cell lung cancer. News release. Merck. August 8, 2024. Accessed August 8, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.merck.com/news/merck-provides-update-on-phase-3-keyvibe-008-trial-evaluating-an-investigational-fixed-dose-combination-of-vibostolimab-and-pembrolizumab-in-patients-with-extensive-stage-small-cell-lung-cancer/">https://www.merck.com/news/merck-provides-update-on-phase-3-keyvibe-008-trial-evaluating-an-investigational-fixed-dose-combination-of-vibostolimab-and-pembrolizumab-in-patients-with-extensive-stage-small-cell-lung-cancer/</a></p><p class="pb-2">2. Merck stops testing combo drug for lung cancer. Reuters. August 8, 2024. Accessed August 8, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.reuters.com/business/healthcare-pharmaceuticals/merck-stops-experimental-lung-cancer-drug-combo-trial-2024-08-08/">https://www.reuters.com/business/healthcare-pharmaceuticals/merck-stops-experimental-lung-cancer-drug-combo-trial-2024-08-08/</a></p><p class="pb-2">3. Ryan C. Merck discontinues KeyVibe-008 trial of vibostolimab/pembrolizumab plus chemo in ES-SCLC. <em>OncLive</em><sup class="text-inherit">®</sup>. August 8, 2024. Accessed August 8, 2024. <a target="_blank" href="https://www.onclive.com/view/merck-discontinues-keyvibe-008-trial-of-vibostolimab-pembrolizumab-plus-chemo-in-es-sclc">https://www.onclive.com/view/merck-discontinues-keyvibe-008-trial-of-vibostolimab-pembrolizumab-plus-chemo-in-es-sclc</a></p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" 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loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a></div></div><div class="relative block sm:hidden"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/achr-ab-titers-associated-with-myasthenia-gravis-severity?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/47d229ce874ed5163de2cbc9c26eb00e443af0cd-1200x738.jpg?fit=crop&auto=format" alt="AChR-Ab titers and the AChR-Ab rates of change correlated with myasthenia gravis disease severity scores in a recent study. | Image credit: luchschenF - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 21st 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/achr-ab-titers-associated-with-myasthenia-gravis-severity?utm_source=www.ajmc.com&utm_medium=relatedContent">AChR-Ab Titers Associated With Myasthenia Gravis Severity</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/achr-ab-titers-associated-with-myasthenia-gravis-severity?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Anti-acetylcholine receptor antibody (AChR-Ab) titers and the AChR-Ab rates of change correlated with myasthenia gravis disease severity scores in a recent study. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-accessing-ketamine-assisted-therapy?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a1728e6a06fccde8af20d2308f860344f9776b8f-800x400.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 14th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-accessing-ketamine-assisted-therapy?utm_source=www.ajmc.com&utm_medium=relatedContent">Frameworks for Advancing Health Equity: Accessing Ketamine-Assisted Therapy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-accessing-ketamine-assisted-therapy?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Jessica Tracy, head of Growth and Partnerships at Enthea, shares how employers and unions can support mental health and address access barriers to evidence-based ketamine treatments.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/abortion-in-2025-access-fertility-and-infant-mortality-updates?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0a1ac834af1e53b8cc045bb074cc7b4ce4ac0f0c-5874x3916.jpg?fit=crop&auto=format" alt="Doctor examines hologram of female uterus | Image Credit: WS Studio 1985 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 20th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/abortion-in-2025-access-fertility-and-infant-mortality-updates?utm_source=www.ajmc.com&utm_medium=relatedContent">Abortion in 2025: Access, Fertility, and Infant Mortality Updates</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/abortion-in-2025-access-fertility-and-infant-mortality-updates?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">While Republican state-led efforts aim to increase restrictions to abortion care and access to mifepristone and misoprostol in 2025, JAMA authors join the conversation with their published research and commentary.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent">Five Years Later: Ongoing COVID-19 Challenges, Next Steps</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with Jenny Han, MD, of Emory School of Medicine and Grady Hospital, about COVID-19, long COVID, and strategies for prevention and care.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/what-recent-evidence-is-telling-us-about-alcohol-and-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c0ffc966125542010d43006654c25de2d5a8b433-141x118.jpg?fit=crop&auto=format" alt="Noelle LoConte, MD | Image credit: University of Wisconsin" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 19th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/what-recent-evidence-is-telling-us-about-alcohol-and-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent">What Recent Evidence Is Telling Us About Alcohol and Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/produced-by-mary-caffrey">Produced by Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/what-recent-evidence-is-telling-us-about-alcohol-and-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Evidence shows alcohol increases estrogen, raising breast cancer risk, with pandemic-related consumption spikes among women.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/2024-caqh-index-foresees-major-opportunity-for-health-care-savings?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/89aba1d1c496bbc7b2bee0c459700a684edfad35-6000x4000.jpg?fit=crop&auto=format" alt="Manual workflows bog down administrative tasks in health care, automated and electronic systems could provide major relief for the health care system | image credit: Nudphon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 18th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/2024-caqh-index-foresees-major-opportunity-for-health-care-savings?utm_source=www.ajmc.com&utm_medium=relatedContent">2024 CAQH Index Foresees Major Opportunity for Health Care Savings</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/2024-caqh-index-foresees-major-opportunity-for-health-care-savings?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This year's report demonstrates the potential impact of automated processes on medical and dental industry spending, with projected savings amounting to $20 billion. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex 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article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 21st 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/achr-ab-titers-associated-with-myasthenia-gravis-severity?utm_source=www.ajmc.com&utm_medium=relatedContent">AChR-Ab Titers Associated With Myasthenia Gravis Severity</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/achr-ab-titers-associated-with-myasthenia-gravis-severity?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Anti-acetylcholine receptor antibody (AChR-Ab) titers and the AChR-Ab rates of change correlated with myasthenia gravis disease severity scores in a recent 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href="/view/frameworks-for-advancing-health-equity-accessing-ketamine-assisted-therapy?utm_source=www.ajmc.com&utm_medium=relatedContent">Frameworks for Advancing Health Equity: Accessing Ketamine-Assisted Therapy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-accessing-ketamine-assisted-therapy?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Jessica Tracy, head of Growth and Partnerships at Enthea, shares how employers and unions can support mental health and address access barriers to evidence-based ketamine treatments.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/abortion-in-2025-access-fertility-and-infant-mortality-updates?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0a1ac834af1e53b8cc045bb074cc7b4ce4ac0f0c-5874x3916.jpg?fit=crop&auto=format" alt="Doctor examines hologram of female uterus | Image Credit: WS Studio 1985 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 20th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a 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class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="managed care cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent">Five Years Later: Ongoing COVID-19 Challenges, Next Steps</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/five-years-later-ongoing-covid-19-challenges-next-steps?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On this episode of Managed Care Cast, we speak with Jenny Han, MD, of Emory School of Medicine and Grady Hospital, about COVID-19, long COVID, and strategies for prevention and care.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div 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About Alcohol and Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/produced-by-mary-caffrey">Produced by Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/what-recent-evidence-is-telling-us-about-alcohol-and-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Evidence shows alcohol increases estrogen, raising breast cancer risk, with pandemic-related consumption spikes among women.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/2024-caqh-index-foresees-major-opportunity-for-health-care-savings?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/89aba1d1c496bbc7b2bee0c459700a684edfad35-6000x4000.jpg?fit=crop&auto=format" alt="Manual workflows bog down administrative tasks in health care, automated and electronic systems could provide major relief for the health care system | image credit: Nudphon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 18th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/2024-caqh-index-foresees-major-opportunity-for-health-care-savings?utm_source=www.ajmc.com&utm_medium=relatedContent">2024 CAQH Index Foresees Major Opportunity for Health Care Savings</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/2024-caqh-index-foresees-major-opportunity-for-health-care-savings?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This year's report demonstrates the potential impact of automated processes on medical and dental industry spending, with projected savings amounting to $20 billion. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"Late-Stage Vibostolimab, Pembrolizumab Plus Chemotherapy Trial Discontinued Due to Adverse Events","datePublished":"2024-08-08T21:42:57.897Z","dateModified":"2024-08-12T12:42:26Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/46ed1f28dea92f2cb13e14b5856c7258caea556e-5000x3750.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/late-stage-trial-discontinued-due-to-adverse-events"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"Merck,vibostolimab/pembrolizumab,anti-TIGIT,vibostolimab","articleBody":"Merck announced today that it would be discontinuing its late-stage trial for vibostolimab/pembrolizumab plus chemotherapy for patients with extensive-stage small cell lung cancer (ES-SCLC).1 The anti–PD-1 therapy was being compared with atezolizumab in combination with chemotherapy in the KeyVibe-008 trial (NCT05224141). However, patients on vibostolimab/pembrolizumab had a higher rate of adverse events (AEs) and immune-related AEs compared with the control arm, leading to its discontinuation.\n\n\n\nVibostolimab is one of several immunotherapies defined as anti-TIGIT. This new class of immunotherapies has been popular for drugmakers, as it has the potential to change how cancer is treated. However, the few trials in the space have been less successful. Anti-TIGIT drugs work by binding themselves to TIGIT, which is a receptor on immune cells.2 The drug then helps to activate the immune system against cancer cells while preventing an immune attack against healthy cells.\n\n\n\nIn previous tests, this combination failed to slow disease progression in patients with lung cancer who had not responded to other treatments and in patients with severe skin cancer. All participants in the study will immediately cease use of the treatment immediately.\n\n\n\nThe trial was a randomized, double-blind study3 that enrolled patients who were 18 years and older with confirmed stage IV ES-SCLC. All participants needed to have a predicted life expectancy of at least 3 months. Patients were excluded if they had poor medical risk, had prior treatment for SCLC, had a live or live-attenuated vaccine within 30 days of the study, and had a history of noninfectious pneumonitis interstitial lung disease, among other exclusion criteria.\n\n\n\nAll participants in the experimental group received 200 mg of vibostolimab and 200 mg of pembrolizumab, plus etoposide and platinum chemotherapy once every 3 weeks for 4 cycles. The other group received 1200 mg of atezolizumab in combination with etoposide and platinum chemotherapy once every 3 weeks for 4 cycles before transitioning to atezolizumab by itself. Participants were allowed to stay in the trial until they met grounds for discontinuation.\n\n\n\nThis cancellation calls into question other ongoing studies involving anti-TIGIT therapies, including the phase 3 studies KeyVibe-003 (NCT04738487), KeyVibe-006 (NCT0529842), and KeyVibe-007 (NCT05226598). Although several companies, such as Gilead Sciences and GSK, are looking into vibostolimab and pembrolizumab as the future of treatment in lung cancer, no previous study has seen any improvement in progression-free or overall survival, and others, such as the KeyVibe-010 trial, have been discontinued. KeyVibe-003 and KeyVibe-006 are both looking into non–small cell lung cancers (NSCLCs) to assess efficacy in that subgroup. These trials are scheduled for completion in 2026, so it remains unknown what the efficacy of either treatment will be.\n\n\n\nAlthough past clinical trials have seen lackluster results, it’s worth looking forward to the results of the clinical trials on the way, as a breakthrough on these treatments could spell a new direction in lung cancer treatment, especially in NSCLC. However, this discontinuation does throw another blow to the use of these therapies in the future.\n\n\n\nReferences\n\n1. Merck provides update on phase 3 KeyVibe-008 trial evaluating an investigational fixed-dose combination of vibostolimab and pembrolizumab in patients with extensive-stage small cell lung cancer. News release. Merck. August 8, 2024. Accessed August 8, 2024. https://www.merck.com/news/merck-provides-update-on-phase-3-keyvibe-008-trial-evaluating-an-investigational-fixed-dose-combination-of-vibostolimab-and-pembrolizumab-in-patients-with-extensive-stage-small-cell-lung-cancer/\n\n2. Merck stops testing combo drug for lung cancer. Reuters. August 8, 2024. Accessed August 8, 2024. https://www.reuters.com/business/healthcare-pharmaceuticals/merck-stops-experimental-lung-cancer-drug-combo-trial-2024-08-08/\n\n3. Ryan C. Merck discontinues KeyVibe-008 trial of vibostolimab/pembrolizumab plus chemo in ES-SCLC. OncLive®. August 8, 2024. Accessed August 8, 2024. https://www.onclive.com/view/merck-discontinues-keyvibe-008-trial-of-vibostolimab-pembrolizumab-plus-chemo-in-es-sclc","description":"A high number of adverse events were reported in a late-stage trial conducted by Merck for treatment in lung cancer.","author":[{"@type":"Person","name":"Julia Bonavitacola"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div class="bg-[#00598D] xl:w-[70%] w-[70%] py-12 pl-auto"><div class="xxl:w-[75%] w-[90%] ml-auto"><div><span 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However, patients on vibostolimab/pembrolizumab had a higher rate of adverse events (AEs) and immune-related AEs compared with the control arm, leading to its discontinuation.","_key":"a5bcd2e70304"}],"_type":"block","upload_doc":null,"uploadAudio":null,"medias":null,"style":"normal","_key":"30aba73d99e5"},{"style":"normal","upload_doc":null,"uploadAudio":null,"medias":null,"_key":"456f083ae94c","markDefs":[],"children":[{"_key":"c3ece3e1156b0","_type":"span","marks":[],"text":""}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"Vibostolimab is one of several immunotherapies defined as anti-TIGIT. This new class of immunotherapies has been popular for drugmakers, as it has the potential to change how cancer is treated. However, the few trials in the space have been less successful. 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The other group received 1200 mg of atezolizumab in combination with etoposide and platinum chemotherapy once every 3 weeks for 4 cycles before transitioning to atezolizumab by itself. 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Although several companies, such as Gilead Sciences and GSK, are looking into vibostolimab and pembrolizumab as the future of treatment in lung cancer, no previous study has seen any improvement in progression-free or overall survival, and others, such as the KeyVibe-010 trial, have been discontinued. KeyVibe-003 and KeyVibe-006 are both looking into non–small cell lung cancers (NSCLCs) to assess efficacy in that subgroup. 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On one hand, some studies indicate that titer changes do not correlate with improvements in disease severity,” the authors wrote. \"...On the other hand, numerous studies have suggested a relationship between changes in AChR-Ab titers and improvements in clinical symptoms.”","_key":"cf0a20afaa0e","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2dac811f116c"}],"_type":"block","style":"normal","_key":"6cf80af9bdcc"},{"markDefs":[],"children":[{"_key":"c3116a10516d","_type":"span","marks":[],"text":"The prospective study included 62 patients with generalized myasthenia gravis who were positive for AChR-Ab. Researchers measured AChR-Ab titers, the Myasthenia Gravis Foundation of America quantitative myasthenia gravis score (QMGS), and myasthenia gravis activities of daily living scale (MG-ADL) scores prior to treatment initiation and at 3 and 6 months into treatment."}],"_type":"block","style":"normal","_key":"215b5caa3518"},{"children":[{"_type":"span","marks":[],"text":"","_key":"87610c0ce016"}],"_type":"block","style":"normal","_key":"84b473ccbaa3","markDefs":[]},{"children":[{"_key":"841e19447b7d","_type":"span","marks":[],"text":"There was no correlation between AChR-Ab titer and age, gender, MGFA classification, duration of illness, or thymic abnormalities at baseline, but decreased AChR-Ab titers at 3 and 6 months vs baseline were significant ("},{"marks":["em"],"text":"P","_key":"cfa5d1efe5f0","_type":"span"},{"text":" = .001 and ","_key":"8a374b20d3e7","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"P","_key":"53e2616218e6"},{"marks":[],"text":" \u003c .001, respectively). The difference between 3 and 6 months was not significant after Bonferroni correction for multiple comparisons, however (","_key":"c5735ce024ef","_type":"span"},{"_key":"6c8c5a65b3f2","_type":"span","marks":["em"],"text":"P"},{"_key":"9ec8f1bd13ef","_type":"span","marks":[],"text":" = .129). This finding indicates that the main decline in antibody titers was within 3 months from treatment initiation."}],"_type":"block","style":"normal","_key":"2e435b23c4b9","markDefs":[]},{"_type":"block","style":"normal","_key":"4c7b5e86fadf","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f879e43475f5"}]},{"style":"normal","_key":"d9f90a06e6ce","markDefs":[],"children":[{"_key":"50974e430367","_type":"span","marks":[],"text":"The decreasing trend in AChR-Ab titers correlated with reductions in QMGS scores ("},{"_type":"span","marks":["em"],"text":"ρ","_key":"a56b18dac9f7"},{"_type":"span","marks":[],"text":" = .187, ","_key":"e469238271e6"},{"_type":"span","marks":["em"],"text":"P","_key":"7ebc81a61479"},{"_type":"span","marks":[],"text":" = .012) and ADL scores (","_key":"08c2fd168c63"},{"_type":"span","marks":["em"],"text":"ρ","_key":"c437a269b19c"},{"text":" = .241, ","_key":"865efcc3887c","_type":"span","marks":[]},{"_key":"b4723cfc0bdc","_type":"span","marks":["em"],"text":"P"},{"_key":"2d60d60847d9","_type":"span","marks":[],"text":" \u003c .05), and there was a high correlation between improving QMGS and ADL scores ("},{"_type":"span","marks":["em"],"text":"ρ","_key":"4e4b7cdc51fa"},{"_type":"span","marks":[],"text":" = .902, ","_key":"11719cac0f9b"},{"_type":"span","marks":["em"],"text":"P","_key":"62e92274aada"},{"_type":"span","marks":[],"text":" \u003c .001).","_key":"98581b63dabd"}],"_type":"block"},{"_key":"38a34618b315","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"424967750bf8"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"5db26ce5cd01","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“These results suggest that the downward trend in AChR-Ab titers is consistent with the improvement in QMGS and ADL scores, with a stronger association with ADL scores,” the authors wrote.","_key":"eaf0af4926ff"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"7e17aa827863"}],"_type":"block","style":"normal","_key":"6aa6ce2791ee","markDefs":[]},{"_key":"71c16f25aa7c","markDefs":[],"children":[{"_key":"e4e97e2f9a9b","_type":"span","marks":[],"text":"At 6 months, there was an association between AChR-Ab titer changes and ADL score changes, and at 3 months, the AChR-Ab titer rate of change was correlated with the ADL rate of change."}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"6fc6aa556ccc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"eb0f9b0bfc9f"}]},{"children":[{"text":"“We found that, after initiating standardized treatment in [patients with myasthenia gravis], decreases in AChR-Ab titers coincided with decreases in QMGS and ADL scores, indicating that the decrease in AChR-Ab antibody titers correlates with improvements in clinical symptoms and enhanced self-care capabilities in patients,” the authors wrote. “Moreover, the primary decrease in AChR-Ab titers occurred within the first 3 months of treatment.”","_key":"e99047834c90","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"79eb7c26560c","markDefs":[]},{"style":"normal","_key":"e326d50a19d7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"edab5bfa0cdc"}],"_type":"block"},{"_type":"block","style":"normal","_key":"37afe48e060d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Based on the study's findings, the authors recommend monitoring AChR-Ab titers at critical follow-ups such as 3 and 6 months post-treatment in patients with myasthenia gravis.","_key":"8561dd86ef44"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"e0d891a80a20","_type":"span"}],"_type":"block","style":"normal","_key":"42beb11ed756"},{"_key":"c3550d84039b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Although AChR-Ab titers may not serve as markers of disease severity, the trend of decreased AChR-Ab titers after treatment initiation consistently aligns with reductions in QMGS and ADL scores,” the authors concluded. “Additionally, the rate of change in AChR-Ab titers correlates with changes in ADL scores after 3 months of treatment; at 6 months, the change in AChR-Ab titers correlates with changes in ADL scores.”","_key":"057e6fb97dfa"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7350d50be100"}],"_type":"block","style":"normal","_key":"15cfc0da377a"},{"markDefs":[],"children":[{"text":"","_key":"5288b299d8d5","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"7062955d2d59"},{"children":[{"text":"References","_key":"bafc81366dc6","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"026f359c7b93","markDefs":[]},{"style":"normal","_key":"141c210fda34","markDefs":[],"children":[{"_key":"8c1f135ee776","_type":"span","marks":[],"text":"1. 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Abortion bans in the wake of the "},{"marks":["em"],"text":"Dobbs v Jackson ","_key":"b03e778c2446","_type":"span"},{"marks":[],"text":"Supreme Court decision in 2022 and the preceding Texas Senate Bill 8 (SB8) in 2021 have introduced legal and ethical dilemmas, prompting a nationwide conversation including various perspectives among physicians, authors, and lawmakers.","_key":"5796cc75ba3f","_type":"span"}],"_type":"block","style":"normal","_key":"33b84c153aee","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"55e859a445a0"}],"_type":"block","style":"normal","_key":"c8f27ca56f72","markDefs":[]},{"markDefs":[],"children":[{"text":"Abortion access continues to be one of the most contentious issues in US health care, according to ","_key":"3bb31b6ce2cd","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"JAMA Health Forum’s","_key":"c7858834ec80"},{"text":" editor in chief, Sandro Galea, MD, DrPh, who emphasized the role of academic medical journals in publishing rigorous research while fostering informed discussion on complex and politically charged topics.","_key":"113d97d42bce","_type":"span","marks":[]},{"_type":"span","marks":["sup"],"text":"1","_key":"c64c743efd96"}],"_type":"block","style":"normal","_key":"81f4293470c5"},{"_key":"fea8276dd648","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6ab68bcb37a9"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“This becomes both particularly important—and particularly difficult—when dealing with issues that are of enormous contemporary consequence and of heated public debate,” he wrote in an editorial published in ","_key":"58cb0905c188"},{"_type":"span","marks":["em"],"text":"JAMA Health Forum","_key":"6b1dd8a521c6"},{"marks":[],"text":".","_key":"1d2007e487dd","_type":"span"}],"_type":"block","style":"normal","_key":"2831846fc907"},{"children":[{"_type":"span","marks":[],"text":"","_key":"72e94bb2d7e2"}],"_type":"block","style":"normal","_key":"525f14392093","markDefs":[]},{"_key":"c1d35de29846","markDefs":[],"children":[{"text":"The topic of abortion restrictions and related impacts were addressed in multiple articles published by ","_key":"f037c84645d7","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"JAMA","_key":"1e90dd8074c7"},{"text":" this week, including a pair of investigations Galea highlighted that examined the real-world effects of abortion bans.","_key":"69023cc3452e","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"style":"normal","_key":"ded03e187f40","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c2b047cd0ae6"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The first study analyzed US national vital statistics data from 2012 to 2023 and found a significant rise in infant mortality following state-level abortion restrictions that translated to an estimated 478 excess infant deaths during the months affected by the bans.","_key":"533a8c20cb80"},{"_type":"span","marks":["sup"],"text":"2","_key":"480e8d065c3f"},{"_type":"span","marks":[],"text":" Across the 14 states with bans, the observed infant mortality rate was 6.26 per 1000 live births compared with an expected rate of 5.93, resulting in an absolute increase of 0.33 (95% credible interval [CrI], 0.14-0.51) and a relative increase of 5.60% (95% Crl, 2.43%-8.73%). Gemmill et al found the impact was particularly severe among Black individuals, those in Southern states, and infants with congenital anomalies.","_key":"613b26120e93"}],"_type":"block","style":"normal","_key":"fd86976e88fd"},{"_key":"a11224e30c80","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1d230476c916"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"An analogous pattern of disparities was exhibited in the second study by Bell et al; more than 20,000 excess births occurred after abortion bans based on an analysis of US Census and birth certificate data.","_key":"381a8e72be7e"},{"_type":"span","marks":["sup"],"text":"3","_key":"ddfabfadb40e"},{"marks":[],"text":" The findings demonstrated disproportionate effects on Medicaid beneficiaries (2.41%), racially diverse communities (≈ 2.0%), individuals younger than 35 years (≈ 2.0%), those without college degrees (high school diploma, 2.36%; some college, 1.58%), and unmarried individuals (1.79%).","_key":"0179f1c82682","_type":"span"}],"_type":"block","style":"normal","_key":"637eca10a152"},{"_key":"1cb6138a8e66","asset":{"_ref":"image-0a1ac834af1e53b8cc045bb074cc7b4ce4ac0f0c-5874x3916-jpg","_type":"reference"},"alt":"Doctor examines hologram of female uterus | Image Credit: WS Studio 1985 - stock.adobe.com","alignment":"right","widthP":38,"_type":"figure","disableTextWrap":false,"disableLightBox":true,"imgcaption":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"How is success measured in abortion outcomes?","_key":"4fe66dedfcda"}],"_type":"block","style":"normal","_key":"8ae2933746f1"},{"children":[{"_type":"span","marks":[],"text":"Image Credit: WS Studio 1985 - stock.adobe.com","_key":"cd843eb16780"}],"_type":"block","style":"normal","_key":"191d0eea6a86","markDefs":[]}]},{"style":"normal","_key":"c8835d472096","markDefs":[],"children":[{"_type":"span","marks":[],"text":"While results yielded from these studies were not entirely surprising to Galeo, he underscored that \"data are necessary, even if not sufficient, to shift the public conversation and to inform decision-making\" and called for \"elevating the visibility of these findings, and disseminating of these ideas in a way that pushes back against misinformation and disinformation.\"","_key":"dedb87c2cdb5"},{"_type":"span","marks":["sup"],"text":"1","_key":"f2769c089c27"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"c01d72f0a4fc"}],"_type":"block","style":"normal","_key":"8ab631b383e0","markDefs":[]},{"_type":"block","style":"normal","_key":"70fb3895c331","markDefs":[],"children":[{"marks":[],"text":"\"A devolution of authority to regulate abortion to the states has led to more restrictive access to abortions in more socially conservative states, and in those states persons who have long historically been marginalized...are less likely to be able to access abortion in those states, resulting in higher birth rates and adverse consequences of childbirth in these groups,\" he wrote. \"And yet, documenting these findings is enormously important and is exactly what academic journals should be doing when societies face complicated and difficult issues such as access to abortion.\"","_key":"7fcee90ae18a","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4d59e17c6439"}],"_type":"block","style":"normal","_key":"567ee4d0a7a5"},{"style":"h3","_key":"ea071f2b4c4a","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Abortion Outcomes: How Is Success Measured?","_key":"1ae3b2b9932d"}],"_type":"block"},{"_type":"block","style":"normal","_key":"c52377222020","markDefs":[{"blank":true,"_type":"link","href":"https://www.nytimes.com/2025/02/13/health/abortion-bans-infant-mortality.html?unlocked_article_code=1.xk4.saYl.0UeOjr69nddp\u0026smid=url-share","_key":"15dc769468b4","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"Some abortion opponents, such as Donna Harrison, MD, of the American Association of Pro-Life Obstetricians and Gynecologists, view the post-","_key":"df814d3f37c7"},{"_type":"span","marks":["em"],"text":"Dobbs","_key":"4eb8657cbeea"},{"marks":[],"text":" rise in birth and subsequent mortality rates as children who would otherwise “have been killed in induced abortions,” according to ","_key":"cae29e4650a7","_type":"span"},{"_type":"span","marks":["15dc769468b4"],"text":"New York Times","_key":"07ba507f4465"},{"text":" coverage.","_key":"e2649d4575cd","_type":"span","marks":[]},{"_type":"span","marks":["sup"],"text":"4","_key":"202545ed7c07"},{"marks":[],"text":" “This means that anyone lamenting the results of this study isn’t really concerned that these babies died; rather, they wish they would have been killed earlier: in the womb,” Harrison said.","_key":"ec125ecf17db","_type":"span"}]},{"_type":"block","style":"normal","_key":"ce8c68e5e9d6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ba2b1c47866f"}]},{"_key":"4d8f29053a9d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Since 2023, the US has seen a slight and consistent increase in the overall number of monthly abortions despite the increase in state restrictions, indicating that the enforcement of bans in certain states may have prompted others to secure existing protections and enhance their abortion access, curbing a potential decline after 2022.","_key":"dfcce848bd88"},{"text":"5,6","_key":"0b653398a881","_type":"span","marks":["sup"]}],"_type":"block","style":"normal"},{"style":"normal","_key":"8e54b4857645","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3c30163130a0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"In Texas, abortion rates have dropped from about 4400 per month in 2021—the year SB8 passed—to a current monthly average of 5.","_key":"6fd5b97ba7c6"},{"_type":"span","marks":["sup"],"text":"5","_key":"6fe827282227"},{"marks":[],"text":" Estimates have shown approximately 35,000 Texas women went out of state for abortion care in 2023, and 75% of abortions performed in New Mexico are provided to out-of-state residents.","_key":"4de01822b237","_type":"span"},{"_type":"span","marks":["sup"],"text":"6","_key":"cce0b89cd777"}],"_type":"block","style":"normal","_key":"00e273559d7e","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"82be5f298499"}],"_type":"block","style":"normal","_key":"3be5b2e687d8"},{"style":"normal","_key":"40fc8050ec9f","markDefs":[{"_type":"link","href":"https://jamanetwork.com/journals/jama/fullarticle/2830293","_key":"483b3cd45dd6","nofollow":true,"blank":true}],"children":[{"_type":"span","marks":[],"text":"Texas has a particularly turbulent history with reproductive rights, preceding ","_key":"24f468a5421a"},{"marks":["em"],"text":"Dobbs v Jackson","_key":"a495ec6a6fc1","_type":"span"},{"_key":"a577266c2fbb","_type":"span","marks":[],"text":" and the passage of SB8, as explained in a "},{"text":"JAMA","_key":"418234ba0992","_type":"span","marks":["483b3cd45dd6","em"]},{"_type":"span","marks":[],"text":" Viewpoint article by Richard Todd Ivey, MD, of the Department of Obstetrics and Gynecology in Baylor College of Medicine in Houston, Texas. These abortion laws have been “recognized as some of the most restrictive antiabortion regulations in the country” and have affected the landscape of reproductive rights and health beyond Texas borders, as observed in 13 additional states with near-total abortion bans.","_key":"c9ac55ffd33b"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"982ef68da214"}],"_type":"block","style":"normal","_key":"9182dc4b1944"},{"children":[{"text":"The state first criminalized abortion in 1854 and again in 1925, only for these laws to be overridden by ","_key":"6a1f9b3685eb","_type":"span","marks":[]},{"text":"Roe v Wade","_key":"677cf4672744","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":" in 1973. However, Texas lawmakers persisted with regulations that included transvaginal ultrasound requirements, mandatory waiting periods, fetal remains burial mandates, and state-mandated counseling that Ivey says includes inaccurate medical information. These laws have steadily eroded access to abortion, culminating in SB8, which not only bans abortion after 6 weeks but also allows private citizens to sue anyone they believe has helped someone obtain an abortion, according to the article.","_key":"0bd05fcf6e52"}],"_type":"block","style":"normal","_key":"790e1718739c","markDefs":[]},{"style":"normal","_key":"c013a8180a86","markDefs":[],"children":[{"marks":[],"text":"","_key":"f61b90abbb70","_type":"span"}],"_type":"block"},{"_type":"block","style":"normal","_key":"708a7414f090","markDefs":[],"children":[{"text":"Polling has indicated most Texans support legal abortion in some circumstances. However, Texas’ current ban offers no exceptions for rape, incest, fetal anomalies, or lethal chromosomal conditions. The only exceptions are ectopic pregnancies and cases where the mother’s life is in danger—though vague legal wording leaves many physicians uncertain about what is legally permissible.","_key":"0570d18e4898","_type":"span","marks":[]}]},{"_key":"49f2d5a4cee7","markDefs":[],"children":[{"text":"","_key":"cfe0e1fa23e8","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"Under Texas law SB8, physicians face severe penalties for violating abortion laws. A ruling from the Texas Supreme Court offered some guidance but lacked legal force, leaving doctors hesitant. Recent cases, such as ","_key":"00b366d26e4a"},{"_type":"span","marks":["em"],"text":"Zurawski v Texas","_key":"8015ce458ce1"},{"marks":[],"text":", show the consequences, with patients suffering from severe complications due to denied abortions, potentially leading to increased maternal fatalities, the article stated.","_key":"a5ee149418b9","_type":"span"}],"_type":"block","style":"normal","_key":"3adc36cb41d1","markDefs":[]},{"style":"normal","_key":"24e5b709ee93","markDefs":[],"children":[{"marks":[],"text":"","_key":"b1b78f305f9a","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"43894ccf27f8","_type":"span","marks":[],"text":"“Make no mistake—the design of these laws is intentional,” Ivey wrote. “The vague wording of the law with detailed, severe penalties for physicians is deliberate. The chilling effect in health care is the desired outcome. The culture of fear among patients and physicians is real. This confusion led the Texas Supreme Court to request clarification from the state medical board. The board opined that the threat to maternal life need not be imminent, but a medical board cannot change law.”"}],"_type":"block","style":"normal","_key":"4234f2844d38"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"bf45f321cba0","_type":"span"}],"_type":"block","style":"normal","_key":"93ec045dc8c5"},{"children":[{"_type":"span","marks":["strong"],"text":"Consequences of “Legislative Intrusion” in Medicine","_key":"2866967d7018"}],"_type":"block","style":"h3","_key":"c9313c20834e","markDefs":[]},{"_type":"block","style":"normal","_key":"bdaa25ccddd7","markDefs":[{"_key":"99b4b83d73f5","nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/view/new-report-shows-worsening-health-outcomes-for-women-in-states-with-abortion-bans"}],"children":[{"_type":"span","marks":[],"text":"Of all US women of reproductive age, 10% reside in Texas.","_key":"9d0a293f333a"},{"_key":"5d488aaae73e","_type":"span","marks":["sup"],"text":"6"},{"text":" This subpopulation is also the most uninsured, with Texas ","_key":"2cfab7b14b6a","_type":"span","marks":[]},{"_type":"span","marks":["99b4b83d73f5"],"text":"ranking lowest","_key":"4727fbf1b612"},{"_type":"span","marks":[],"text":" across all 50 states for health care coverage and affordability in The Commonwealth Fund’s 2024 State Scorecard on Women’s Health and Reproductive Care.","_key":"af8a6423301f"},{"text":"7","_key":"703566984416","_type":"span","marks":["sup"]},{"_type":"span","marks":[],"text":" In 2022, 27% of Texas women went without needed care due to access issues.","_key":"02a3ce78e750"},{"marks":["sup"],"text":"6","_key":"bee0df368ce6","_type":"span"},{"_type":"span","marks":[],"text":" The state only recently extended postpartum Medicaid coverage to 1 year—far later than many other states.","_key":"1a3e3973718c"}]},{"_type":"block","style":"normal","_key":"458d6d17f314","markDefs":[],"children":[{"_key":"ea0ab07021bd","_type":"span","marks":[],"text":""}]},{"style":"normal","_key":"1dc16380c343","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Adding to the crisis is a worsening provider shortage, Ivey explained. Nearly half (48%) of practicing obstetrician-gynecologists (ob-gyns) nationwide are older than 55 years and expected to retire in the next decade. Texas is already seeing a decline in ob-gyn residency applications, with 57% of residents reporting that abortion laws are influencing their decision to leave the state after training. This exodus could have dire consequences, particularly in the 47% of Texas counties that are classified as maternity deserts; 17 rural labor and delivery units have closed in the last decade.","_key":"7ab04c9de839"}],"_type":"block"},{"markDefs":[],"children":[{"text":"","_key":"3d569c8bb7b7","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"cf93b2d208b1"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"e87760af48a2"},{"_type":"span","marks":["em"],"text":"Dobbs","_key":"cf96f15ba9f6"},{"_type":"span","marks":[],"text":" decision set forth a ripple effect of trigger laws and abortion bans that impacted the entire country, with restrictions imposed in some states while other states simultaneously aimed to fill those access gaps. However, it hasn't decreased the occurrence of abortion nationwide—possibly even moving the needle slightly in the opposite direction, as speculated in the Society of Family Planning report.","_key":"95d4d106977f"},{"_type":"span","marks":["sup"],"text":"5","_key":"6424813c79a0"}],"_type":"block","style":"normal","_key":"a9f37b57e633"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"4a13dd3ea97c","_type":"span"}],"_type":"block","style":"normal","_key":"ed10535672d3"},{"children":[{"_type":"span","marks":["strong"],"text":"Reproductive Restrictions 2025: Current Policy Conversations","_key":"08131714422c"}],"_type":"block","style":"h3","_key":"bc462ada3bbd","markDefs":[]},{"_key":"088813ba90e1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Texas isn’t the only state setting trends in restricting abortion; key legislative efforts in Republican-led states to classify mifepristone and misoprostol as controlled dangerous substances have gained traction.","_key":"0612f0edc2f6"},{"_type":"span","marks":["sup"],"text":"8","_key":"8b55a1808155"},{"_type":"span","marks":[],"text":" Measures have been introduced in various states, including Idaho, Oklahoma, Tennessee, and Texas, aiming to replicate Louisiana, the first state to reclassify the medications as Schedule IV controlled substances under the state’s Controlled Dangerous Substances Law. ","_key":"6b496dcc8bc2"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"a8934894e6ad","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"901d18f101ff"},{"markDefs":[{"_key":"8ffd233454bc","nofollow":true,"blank":true,"_type":"link","href":"https://jamanetwork.com/journals/jama/fullarticle/2830292"}],"children":[{"_type":"span","marks":[],"text":"This move, enabled through Senate Bill 276, places these widely used reproductive health medications under the same regulatory framework as sedatives and barbiturates—despite clear scientific evidence that they do not pose a risk for addiction or abuse, according to ","_key":"36fb00bb63bb"},{"_type":"span","marks":["8ffd233454bc"],"text":"another ","_key":"e059d7f48aae"},{"_key":"8a160a6630c8","_type":"span","marks":["8ffd233454bc","em"],"text":"JAMA"},{"_type":"span","marks":["8ffd233454bc"],"text":" Viewpoint article","_key":"60b4b2998d62"},{"_type":"span","marks":[],"text":".","_key":"0313e4b21e4a"},{"_type":"span","marks":["sup"],"text":"9","_key":"8689720197a6"}],"_type":"block","style":"normal","_key":"07ddf7769ca5"},{"_key":"f3c8acf711ee","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"847ce836b964"}],"_type":"block","style":"normal"},{"children":[{"marks":[],"text":"Scientific data overwhelmingly confirm that mifepristone and misoprostol do not have addictive properties, these authors note. Neither drug affects the brain’s reward system, nor do they produce euphoria or withdrawal symptoms. Mifepristone, a progesterone receptor antagonist, is approved by the FDA for medication abortion and for managing hyperglycemia in patients with Cushing disease. Misoprostol, a prostaglandin E1 analog, is widely used in obstetrics and gynecology for labor induction, miscarriage management, and postpartum hemorrhage—one of the leading causes of maternal death.","_key":"d453bd9e41a3","_type":"span"}],"_type":"block","style":"normal","_key":"de86ad93c318","markDefs":[]},{"_key":"47611fe0486a","markDefs":[],"children":[{"text":"","_key":"2ca5a39acac1","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_key":"16b3fec484df","markDefs":[],"children":[{"_key":"bc3afd99a115","_type":"span","marks":[],"text":"While some attempts have already stalled in Indiana and Mississippi, experts state that even if these bills do not pass, their repeated introduction could help normalize restrictions on abortion medication."},{"_type":"span","marks":["sup"],"text":"8,9","_key":"b87962968fab"},{"_key":"123d1998e9f2","_type":"span","marks":[],"text":" Louisiana’s legislation “was not designed to make care safer or to improve health outcomes—rather, it increases barriers to health care and raises unnecessary fear around prescribing and dispensing these medications.”"},{"_type":"span","marks":["sup"],"text":"9","_key":"8c768bb2c67f"}],"_type":"block","style":"normal"},{"_key":"592aae93245d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f6fdab1062df"}],"_type":"block","style":"normal"},{"children":[{"_key":"2ac789999c70","_type":"span","marks":[],"text":"The debate on abortion access will continue, as will disagreements on the role of government in health care policy."},{"_type":"span","marks":["sup"],"text":"6","_key":"653d5cbb5062"},{"_type":"span","marks":[],"text":" Yet, Ivey argues that ongoing legislative interference in medical decision-making is inappropriate and impacts the health and well-being of patients and physicians. Specifically, he calls out harmful \"laws that require physicians to give, withhold, or restrict information that can be shared with patients; laws that mandate tests, procedures, or treatments; laws that criminalize evidence-based care; or laws that create content-specific informed consent.\"","_key":"a53f73b3c1c6"}],"_type":"block","style":"normal","_key":"7235059b64e9","markDefs":[]},{"_key":"539fc810157a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"50ca5bdb7ab4"}],"_type":"block","style":"normal"},{"_key":"2c723e249c86","markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"Health care policy determined by ideology is nothing short of dangerous,\" he concluded.","_key":"b6227e425d5c"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"6a85e81a0440"}],"_type":"block","style":"normal","_key":"f409114096a7","markDefs":[]},{"style":"normal","_key":"76baded918c8","markDefs":[],"children":[{"text":"Galea reinforced the power of complementing thorough peer-reviewed data with thoughtful commentary published in academic journals.","_key":"952376db3163","_type":"span","marks":[]},{"_type":"span","marks":["sup"],"text":"1","_key":"ce0bfda29e5e"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"339dfbfd724b"}],"_type":"block","style":"normal","_key":"f3fb60eb7f46","markDefs":[]},{"_key":"11c78c7160ee","markDefs":[],"children":[{"_key":"3e9be714cdb6","_type":"span","marks":[],"text":"\"There is plenty of evidence about the gap between data and implementation and between the generation of evidence and policy change,\" he wrote. \"However, this is exactly how a knowledge base is built, and how we can create a scaffold of ideas that inform public debate, and eventually change policy.”"}],"_type":"block","style":"normal"},{"children":[{"_key":"2f14b9fa619c","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"2b0965327e9e","markDefs":[]},{"_key":"5dbce8f19858","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a315cd158bf0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"94350e8f364c","_type":"span","marks":["strong"],"text":"References"}],"_type":"block","style":"normal","_key":"8c4d28fabb19"},{"_key":"9a897cee30ba","markDefs":[],"children":[{"_type":"span","marks":[],"text":"1. Galea S. Research on difficult social issues—the consequences of abortion bans. ","_key":"976289d7fb95"},{"text":"JAMA Health Forum.","_key":"9a8dfffef94d","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":" 2025;6(2):e250087. doi:10.1001/jamahealthforum.2025.0087","_key":"49409088642a"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"491ee6848866","markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/abortion-bans-linked-to-higher-infant-mortality-disproportionately-impact-black-infants","_key":"22214593fb6c"}],"children":[{"_type":"span","marks":[],"text":"2. Steinzor P. Abortion bans linked to higher infant mortality, disproportionately impact Black infants. ","_key":"56be59176172"},{"_key":"16d83729b9e4","_type":"span","marks":["em"],"text":"AJMC"},{"text":"®","_key":"aaa9e37d57a3","_type":"span","marks":["sup"]},{"_type":"span","marks":[],"text":". February 13, 2025. Accessed February 13, 2025. 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"},{"_type":"span","marks":["em"],"text":"JAMA.","_key":"d96a8a2453ed"},{"_type":"span","marks":[],"text":" Published online February 13, 2025. doi:10.1001/jama.2025.0381","_key":"a6c4aee37e96"}],"_type":"block","style":"normal","_key":"6aa436a7c6f0"},{"markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/new-report-shows-worsening-health-outcomes-for-women-in-states-with-abortion-bans","_key":"d25b6324f35f"}],"children":[{"_key":"36295fb37c3b","_type":"span","marks":[],"text":"7. Grossi G. New report shows worsening health outcomes for women in states with abortion bans. "},{"_type":"span","marks":["em"],"text":"AJMC","_key":"ae42c1be46bc"},{"text":". July 18, 2024. Accessed February 14, 2025. ","_key":"bb1ed079ffb2","_type":"span","marks":[]},{"_type":"span","marks":["d25b6324f35f"],"text":"https://www.ajmc.com/view/new-report-shows-worsening-health-outcomes-for-women-in-states-with-abortion-bans","_key":"b27f4e956307"}],"_type":"block","style":"normal","_key":"6d6c766fc232"},{"_key":"b6398322ba2f","markDefs":[{"_type":"link","href":"https://www.pbs.org/newshour/nation/what-to-know-about-state-proposals-to-ban-abortion-pills-and-punish-women-who-seek-to-end-pregnancies","_key":"5020ae1bf494"}],"children":[{"_key":"5ab87bae2075","_type":"span","marks":[],"text":"8. Mulvihill G. What to know about state proposals to ban abortion pills and punish women who seek to end pregnancies. PBS. February 11, 2025. Accessed February 16, 2025. 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In December 2020, as alcohol use was rising around the globe during the COVID-19 pandemic, the National Cancer Institute (NCI) convened a workshop and public webinar of experts to evaluate existing evidence and identify gaps in what was known about the connections between alcohol and cancer.","_key":"550a509619e0"},{"text":"1 ","_key":"6d99c7ec5c11","_type":"span","marks":["sup"]},{"_type":"span","marks":[],"text":"The group also discussed what can be done to better communicate alcohol’s mortality risks.","_key":"26da5dfd380c"}],"_type":"block"},{"_type":"figure","imgcaption":[{"markDefs":[],"children":[{"marks":[],"text":"Noelle LoConte, MD | Image credit: University of Wisconsin","_key":"edcb31bc02b9","_type":"span"}],"_type":"block","style":"normal","_key":"803e83b1bdfb"}],"alignment":"left","asset":{"_ref":"image-c0ffc966125542010d43006654c25de2d5a8b433-141x118-jpg","_type":"reference"},"disableTextWrap":false,"disableLightBox":true,"alt":"Noelle LoConte, MD | Image credit: University of Wisconsin","widthP":25,"_key":"5956d0c5cd9a"},{"_type":"block","style":"normal","_key":"a4ad956fb437","markDefs":[],"children":[{"_type":"span","marks":[],"text":"One of those experts was Noelle LoConte, MD, a hematologist and medical oncologist at the University of Wisconsin–Madison and lead author of a 2018 statement on alcohol and cancer for the American Society of Clinical Oncology.","_key":"aaa1035f7441"},{"_type":"span","marks":["sup"],"text":"2","_key":"88bcf28f07c9"},{"_type":"span","marks":[],"text":" In 2023, LoConte was the senior author of a survey of Wisconsin patients with cancer, which found that increased alcohol consumption during the pandemic was associated with financial hardship and declining mental health.","_key":"df85e86b1b26"},{"marks":["sup"],"text":"3","_key":"8252668a7159","_type":"span"},{"marks":[],"text":"\n\nGiven that evidence about alcohol and cancer has been accumulating for decades, ","_key":"12b8ed84c9ce","_type":"span"},{"_key":"e44c47ab28ed","_type":"span","marks":["em"],"text":"Evidence-Based Oncology"},{"marks":[],"text":" (","_key":"2908eca9819e","_type":"span"},{"_type":"span","marks":["em"],"text":"EBO","_key":"5fb2b9a27b10"},{"_type":"span","marks":[],"text":") asked LoConte: What has changed? Here are LoConte’s answers to questions from ","_key":"39db32589cee"},{"_key":"4b111cd02193","_type":"span","marks":["em"],"text":"EBO"},{"text":", edited lightly for clarity:\n\n","_key":"b27e80ab3502","_type":"span","marks":[]},{"marks":["strong","em"],"text":"EBO:","_key":"3572d179b954","_type":"span"},{"_type":"span","marks":[],"text":" What are the most important things we have learned about the mechanisms of how alcohol drives cancer risk? Is there new evidence that has come to light that moved us past a “tipping point” and toward a stronger public education effort?\n\n","_key":"0d7570f2770d"},{"_type":"span","marks":["strong"],"text":"LoConte:","_key":"612f1559f43b"},{"_type":"span","marks":[],"text":" There is some newer evidence that, in my mind, has proven the “abstainer bias” as the cause of the J-shaped curve that, for some time, seemed to favor that 1 drink a day is healthier than not drinking [or drinking more]. The 2023 study","_key":"871e27b38860"},{"text":"4","_key":"9272412728e9","_type":"span","marks":["sup"]},{"marks":[],"text":" I am referring to was able to control for people [who] abstained but previously drank vs those who never drank. The abstainers group likely drank enough for that to impact their current health. The never-drinkers, indeed, were the healthiest group.\n\n","_key":"0bbbc6a1ace6","_type":"span"},{"_type":"span","marks":["strong","em"],"text":"EBO","_key":"4b5c7458be9a"},{"marks":["strong"],"text":": ","_key":"0ee115e56254","_type":"span"},{"_type":"span","marks":[],"text":"We have heard more about increased alcohol use among women. What are the particular issues with how alcohol drives cancer risk in the body that are of special concern to women?","_key":"d313bc8c8aaa"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"\n","_key":"e44c502ebca2"},{"_type":"span","marks":["strong"],"text":"LoConte: ","_key":"121cb7c0657d"},{"_type":"span","marks":[],"text":"The major concern here is breast cancer. Alcohol raises estrogen, which in turn raises the risk of breast cancer. The other issue is that alcohol use among women was shown to increase greatly during and after the pandemic,","_key":"b66644f79e72"},{"text":"5,6","_key":"e1c4bdff799e","_type":"span","marks":["sup"]},{"text":" which, based on other stressful events that led to communities increasing their alcohol consumption, [such as] 9/11 or Hurricane Katrina, will likely be sustained use.\n\n","_key":"acdf1ad5d052","_type":"span","marks":[]},{"text":"EBO","_key":"076f144176fe","_type":"span","marks":["strong","em"]},{"_type":"span","marks":["strong"],"text":":","_key":"d14516debce4"},{"_type":"span","marks":[],"text":" The 2020 NCI workshop","_key":"27459ad67dc4"},{"_type":"span","marks":["sup"],"text":"1","_key":"2c174d1b9556"},{"_type":"span","marks":[],"text":" addressed the challenges of communication on alcohol and cancer risk. What do you see as the chief barriers to building public awareness and acceptance that this risk merits action?\n","_key":"47c81393647e"},{"marks":["strong"],"text":"\nLoConte:","_key":"9c0ca59f3259","_type":"span"},{"_type":"span","marks":[],"text":" It’s a nuanced message—it’s some cancers, not all cancers. Some moderate or intermittent use likely is OK. The way alcohol causes cancer is variable, depending on the cancer, etc. That makes pithy or quick messaging hard. The other barrier is that a lot of doctors drink. For example, we know that doctors who are obese are less likely to speak to their patients about obesity, and back in the day, doctors who smoked were less likely to address tobacco use with their patients. Lastly, the alcohol industry is a powerful industry that is opposed to this messaging about alcohol as a carcinogen. \n\n","_key":"03aedddcbbf4"},{"_type":"span","marks":["strong"],"text":"References","_key":"da7d94cb46f0"},{"marks":[],"text":"\n1. Gapstur SM, Bandera EV, Jernigan DH, et al. Alcohol and cancer: existing knowledge and evidence gaps across the cancer continuum.","_key":"a6c5c1251678","_type":"span"},{"_type":"span","marks":["em"],"text":" Cancer Epidemiol Biomarkers Prev. ","_key":"e3e75d31f6db"},{"_type":"span","marks":[],"text":"2022;31(1):5-10. doi:10.1158/1055-9965.EPI-21-0934","_key":"4d8b45186116"}],"_type":"block","style":"normal","_key":"95054afd5982"},{"style":"normal","_key":"135761abeb23","markDefs":[],"children":[{"_type":"span","marks":[],"text":"2. LoConte NK, Brewster AM, Kaur JS, Merrill JK, Alberg AJ. Alcohol and cancer: a statement of the American Society of Clinical Oncology. ","_key":"c215d9f7ce8d"},{"_type":"span","marks":["em"],"text":"J Clin Oncol.","_key":"6ad460926466"},{"_type":"span","marks":[],"text":" 2018;36(1):83-93. doi:10.1200/JCO.2017.76.1155","_key":"7d73e039cecb"}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"3. Lawler T, Anderson SW, Trentham-Dietz A, et al. Change in alcohol consumption during the Covid-19 pandemic and associations with mental health and financial hardship: results from a survey of Wisconsin patients with cancer. ","_key":"59c82868408d","_type":"span"},{"_key":"93109cf4afad","_type":"span","marks":["em"],"text":"J Cancer Surviv"},{"_key":"bc4bdf464a9a","_type":"span","marks":[],"text":". Published November 28, 2023. doi:10.1007/s11764-023-01502-1"}],"_type":"block","style":"normal","_key":"55e287b5acbf"},{"_type":"block","style":"normal","_key":"7016f73a4bd9","markDefs":[],"children":[{"_key":"43595cb7eb95","_type":"span","marks":[],"text":"4. Zhao J, Stockwell T, Naimi T, Churchill S, Clay J, Sherk A. Association between daily alcohol intake and risk of all-cause mortality: a systematic review and meta-analyses. "},{"text":"JAMA Netw Open","_key":"a6793e0e36d4","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":". 2023;6(3):e236185. doi:10.1001/jamanetworkopen.2023.6185","_key":"856cdb53714f"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"5. Hahm HC, Hsu KC, Hyun S, Kane K, Liu CH. Psychological distress and heavy alcohol consumption among US young women during the COVID-19 pandemic. ","_key":"247907fd46c4"},{"_key":"9d6cedda92c5","_type":"span","marks":["em"],"text":"Womens Health Issues"},{"_type":"span","marks":[],"text":". 2023;33(1):17-24. doi:10.1016/j.whi.2022.09.002","_key":"86dbfafca70a"}],"_type":"block","style":"normal","_key":"867e269f2c30"},{"style":"normal","_key":"b2dbc5408c0a","markDefs":[],"children":[{"text":"6. Moskatel LS, Slusky DJG. The impact of COVID-19 on alcohol sales and consumption in the United States: a retrospective, observational analysis. ","_key":"26c005235f12","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"Alcohol. ","_key":"b1f417aae7b8"},{"_type":"span","marks":[],"text":"2023;111:25-31. doi:10.1016/j.alcohol.2023.05.003","_key":"23a2fa98d05f"}],"_type":"block"}],"is_visible":true,"_createdAt":"2025-02-19T03:48:11Z","title":"What Recent Evidence Is Telling Us About Alcohol and Cancer","factCheckAuthorMapping":null,"summary":"Evidence shows alcohol increases estrogen, raising breast cancer risk, with pandemic-related consumption spikes among women.","articleType":"Publication","audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/e4a32dfb-8008-41b9-82e8-569d97a87e7f_1739937000917.3c8c2e5c-4ce3-435e-9bfb-43280d387df2.mp3","_id":"e4a32dfb-8008-41b9-82e8-569d97a87e7f","drugMentions":"{\"drug_mentions\": [\"alcohol\", \"estrogen\"]}","seoTag":["alcohol","cancer","evidence","University of Wisconsin","National Cancer Institute","ASCO","abstainer bias","health related social needs"],"authors":[{"displayName":"Produced by Mary Caffrey","url":"produced-by-mary-caffrey"}],"factCheckAuthors":null,"gptSummary":"The US Surgeon General's report on alcohol and cancer risk aligns with longstanding research. A 2020 NCI workshop highlighted the need for better communication on this issue. Noelle LoConte, MD, emphasized the \"abstainer bias\" in alcohol studies and the specific risk of breast cancer in women due to increased estrogen levels. The pandemic exacerbated alcohol consumption, particularly among women, raising concerns. Communication challenges include the nuanced nature of alcohol's cancer risk, doctors' personal habits, and the alcohol industry's opposition to carcinogen messaging.","thumbnail":{"hotspot":{"_type":"sanity.imageHotspot","width":1,"x":0.5,"y":0.5254237288135594,"height":0.9491525423728814},"_type":"mainImage","alt":"Noelle LoConte, MD | Image credit: University of Wisconsin","caption":"Noelle LoConte, MD | Image credit: University of Wisconsin","asset":{"_ref":"image-c0ffc966125542010d43006654c25de2d5a8b433-141x118-jpg","_type":"reference"},"crop":{"_type":"sanity.imageCrop","right":0,"top":0.05084745762711864,"left":0,"bottom":0}},"documentGroup":null,"url":"what-recent-evidence-is-telling-us-about-alcohol-and-cancer","_rev":"CSoY17EC9M4O2Sf97ZO7Dt","issueSection":{"_ref":"65282bb4-b905-43a3-b11d-b9c4483f3438","_type":"reference"},"issueGroup":{"_ref":"6d917ea7-7e09-4a04-9a3f-85d7c6439c68","_type":"reference"},"documentGroupMapping":null,"_updatedAt":"2025-02-20T15:07:40Z","pageNumber":"SP74","gptTakeaways":"• The \"abstainer bias\" in alcohol studies has been challenged, showing never-drinkers as the healthiest group.\n\n• Alcohol increases estrogen, raising breast cancer risk, with pandemic-related consumption spikes among women.\n\n• Communicating alcohol's cancer risk is complex due to its variability and the influence of the alcohol industry.\n\n• Doctors' personal alcohol use may hinder effective patient communication about alcohol-related cancer risks.","targeting":{"content_placement":["topic/clinical","compendium/womens-health"],"document_url":["what-recent-evidence-is-telling-us-about-alcohol-and-cancer"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"AChR-Ab Titers Associated With Myasthenia Gravis Severity","url":{"current":"achr-ab-titers-associated-with-myasthenia-gravis-severity","_type":"slug"},"thumbnail":{"_type":"mainImage","alt":"AChR-Ab titers and the AChR-Ab rates of change correlated with myasthenia gravis disease severity scores in a recent study. | Image credit: luchschenF - 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Not only would these initiatives reduce waste and alleviate administrative burdens, but they could also bring down costs and allow for more concerted efforts to improve patient care and access.","_key":"8a4cd5d34f39"},{"_type":"span","marks":["sup"],"text":"1","_key":"a3442e7fdb68"}],"_type":"block","style":"normal","_key":"9a412028f896"},{"_key":"d19198d2cd94","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.caqh.org/news/new-caqh-index-reveals-20b-savings-opportunity-to-cut-waste-reduce-costs-and-improve-patient-access","_key":"f30e4baa385e"},{"blank":true,"_type":"link","href":"https://www.ajmc.com/partners/caqh","_key":"6c930d5b52a3","nofollow":false}],"children":[{"_type":"span","marks":[],"text":"“Healthcare should be about patients, not paperwork,” Sarah Ahmad, CEO of ","_key":"b4516ff510b6"},{"_key":"00ef58f35210","_type":"span","marks":["6c930d5b52a3"],"text":"CAQH"},{"_key":"8f4280556710","_type":"span","marks":[],"text":", said in a "},{"_type":"span","marks":["f30e4baa385e"],"text":"statement","_key":"e4d14d100150"},{"_type":"span","marks":[],"text":".","_key":"3443cb3be372"},{"_type":"span","marks":["sup"],"text":"2","_key":"f4076d75a6e3"},{"_type":"span","marks":[],"text":" “The efficiencies gained through automation are not just numbers on a page; they represent time returned to patients, resources reallocated to care, and stress removed from already burdened systems.”","_key":"ed557f360e87"}],"_type":"block","style":"normal"},{"_key":"91fd0a833d70","asset":{"_ref":"image-fd38171d9f05fa36e30cd34c60777981e9667cb6-3796x2000-jpg","_type":"reference"},"_type":"figure","alignment":"right","disableTextWrap":false,"disableLightBox":true,"imgcaption":[{"_type":"block","style":"normal","_key":"dedc735b38f9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Manual workflows bog down administrative tasks in health care, automated and electronic systems could provide major relief for the health care system | image credit: Valeri Luzina - stock.adobe.com","_key":"920cf974dab5"}]}],"alt":"Manual workflows bog down administrative tasks in health care, automated and electronic systems could provide major relief for the health care system | image credit: Valeri Luzina - stock.adobe.com","widthP":35},{"_key":"5e56a8ab096c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"This annual report, published since 2011, has been a valuable resource for federal agencies, researchers, providers, and industry leaders alike for considerations related to resource allocation, regulatory development, and all-around prioritization.","_key":"8d22373b3bb9"},{"_type":"span","marks":["sup"],"text":"1","_key":"326c5baa3bb6"},{"_type":"span","marks":[],"text":" In this year’s report, insights from patients and providers were highlighted to demonstrate the real-world effects of health care processes and transactions. More than 600 organizations throughout the dental and medical fields, as well as health plans, collaborated in this effort, representing 63% of insured individuals.","_key":"67837ed530ea"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The report finds that administrative process greatly benefited from the adoption of fully electronic transactions, web portals, artificial intelligence (AI), and interactive voice response systems, among other forms of automation. The adoption of automated processes grew by an average of 2 percentage points, allowing the medical and dentistry industries to keep their administrative spending steady while contending with staff shortages, rising staff costs, and spending on administrative tasks. Furthermore, the volume of administrative transactions for the medical and dental industries increased by 13% and 20%, with the total electronic volume rising by 15% and 33%, respectively. As a result, more services are being provided to patients in a more efficient, streamlined manner.","_key":"2f55cea4a303"}],"_type":"block","style":"normal","_key":"fccb87ef14ac"},{"markDefs":[],"children":[{"text":"In 2024, “Automation helped the industry avoid spending $222 billion on administrative tasks measured in the CAQH Index — a 15 percent increase from the previous year,” the report states. “Reducing manual tasks not only lowered costs and saved time but has the potential to boost staff satisfaction and ultimately patient care.”","_key":"975003909eb8","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"ac909cb55d9a"},{"_key":"57b9ecd579a7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"When it came to electronic eligibility and benefit verification, automation adoption increased for both the medical and dental industries in 2024 (2% and 3%, respectively).","_key":"5e3105a0cf94"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"ef6921038d1f","_type":"span","marks":[],"text":"In total, the opportunity to save on costs for the medical industry rose to $18.4 billion, a 12% increase, and for the dental industry to $2.1 billion, constituting an 11% increase. Additionally, medical plans and providers saw a 5% increase in verifications, totaling 31.5 billion, and the dental industry saw a 24% increase, totaling 1.2 billion. When these checks are done electronically, rather than manually, the repots estimates that the medical industry could save upwards of $11.7 billion, a 27% increase, and the dental industry upwards of $580 million, a 7% increase."}],"_type":"block","style":"normal","_key":"a4f5d1685a0a"},{"_key":"b8072abb91ad","markDefs":[],"children":[{"_key":"ca101ef67c34","_type":"span","marks":[],"text":"Other highlights from the report included a 3% reduction in prior authorization volume—which remains one of the most time-consuming processes for providers and can greatly delay care. This result could be due to 25% of medical services no longer mandating precertification or prior authorization."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Electronic claims submissions also saw an increase for the medical and dental industries (1% and 16%, respectively) while manual submissions declined (6% and 14%). Spending related to claims submission, however, rose by 1% and 13% in the medical and dental industries. The report spotlights that, although these increases could be considered minor, administrative spending dedicated to claim submission makes up 23% and 21% of the medical and dental industries’ total spending for the year. Accurate claim submission remains a priority for providers in these fields, the report adds, due to “concern over the growing number of denials, as some plans have begun relying more on artificial intelligence (AI) to review submitted claims, which may result in delayed payments and multiple submissions to resolve as models and algorithms continue to become more refined.”","_key":"1124dc621c41"}],"_type":"block","style":"normal","_key":"beb4a16aa117"},{"_type":"block","style":"normal","_key":"cb62826fcc17","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Ultimately, this report demonstrates the potential benefits to patients from more cost-effective and streamlined health care. The integration of automated systems and AI have shown to be useful for tackling the inefficiencies that lead to care delays and growing costs, while also enhancing data management and cybersecurity. Collaborative efforts between stakeholders remains imperative as these industries seek to build a better care network for their patients.","_key":"1c7e435b961d"}]},{"children":[{"_type":"span","marks":[],"text":"“By centering patients and providers in the conversation and fostering collaboration, this year’s Index not only identifies inefficiencies but offers actionable insights to transform the system,” Erin Weber, chief policy and research officer, CAQH, said in the ","_key":"fac868d71610"},{"marks":["0c12bbb1e89e"],"text":"statement","_key":"6990b749cd55","_type":"span"},{"_type":"span","marks":[],"text":".","_key":"a4cbd858afbd"},{"_key":"ce12e1b0337e","_type":"span","marks":["sup"],"text":"2"},{"_key":"0a66baea85b4","_type":"span","marks":[],"text":" At present, routine administrative processes, including verifying insurance, contribute to $90 billion in annual spending. 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