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<!DOCTYPE html> <html>  <head> <meta charset="UTF-8"> <meta http-equiv="Cache-Control" content="no-store"> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <title> KEGG PATHWAY: Terpenoid backbone biosynthesis - Reference pathway </title> <link rel="stylesheet" href="/css/kegg.css" type="text/css" /> <link rel="stylesheet" href="/css/jquery-ui.css" /> <style type="text/css">  </style> <script src="/js/jquery-3.1.0.min.js"></script> <script src="/js/jquery-ui.js"></script> <script src="/js/jquery.balloon.min.js"></script> <script src="/js/lz-string.min.js"></script> <script src="/kegg-bin/get_data.cgi?data=0021&id=show_pathway.merged.js&v2.11"></script> <script type="text/javascript">  </script> </head> <body>  <h1 class="page-title"> <a href="/kegg/pathway.html"><img alt="KEGG" border="0" src="/Fig/bget/kegg3.gif" /></a>  Terpenoid backbone biosynthesis - Reference pathway </h1>   <div class="nav"> [ <a href="/brite/query=00900&htext=br08901.keg&option=-a&node_proc=br08901_org&proc_enabled=map&panel=collapse" id="navPathwayMenu">Pathway menu</a> | <a id="navOrganismGroup" href="/kegg-bin/organism_stat?mapno=00900">Organism group</a> | <a href="/entry/map00900" id="navPathwayEntry">Pathway entry</a> | <a id="descLink" href="#description">Show description</a> | <a id="downloadMenu" href="#">Download</a> | <a href="javascript:void(window.open('/kegg/document/help_pathway.html','KEGG_Help','width=720,height=640'))">Help</a> ] <div id="description" class="hidden"> Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:<a href="/module/M00095">M00095</a>] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:<a href="/module/M00096">M00096</a>], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil monoterpenes and linalyl acetate, some sesquiterpenes, diterpenes, and carotenoids and phytol. The mevalonate pathway, operating in the cytosol, gives rise to triterpenes, sterols, and most sesquiterpenes. </div>  <form name="selmenu" method="get"> <input type="button" id="changePathwayTypeButton" value="Change pathway type"> <input type="text" class="hidden" name="mapno" value="00900" /> <input type="text" class="hidden" id="scale" name="scale" value="1" /> <input type="text" class="hidden" id="displayNoColoringImage" name="nocolor" value="0" /> <input type="text" class="hidden" id="displayDescription" name="show_description" value="hide" /> <input type="text" class="hidden" id="displayControlPanel" name="show_module_list" value="show" /> <input type="text" class="hidden" id="clickableMode" name="clickable_mode" value="" /> <input type="text" class="hidden" name="module" value="" /> </form>  </div>   <div class="image-block" style="position:static;"> <img src="/kegg/pathway/map/map00900.png?17403942631836318" srcset="/kegg/pathway/map/map00900.png?17403942631836318 1x" data-srcset="/kegg/pathway/map/map00900.png 1x" id="pathwayimage" usemap="#mapdata" border="0" width="1024" /> <map id="mapdata" name="mapdata" data-scale="1"> <area id="7CFA56CB" shape="circle" coords="325,1187,4" class="original" href="/entry/C05859" title="C05859 (ditrans,polycis-Polyprenyl diphosphate)" data-entry="C05859" /> <area id="7CE1A199" shape="circle" coords="253,1187,4" class="original" href="/entry/C06081" title="C06081 (Polyprenol)" data-entry="C06081" /> <area id="E8703CBB" shape="circle" coords="645,186,4" class="original" href="/entry/C00022" title="C00022 (Pyruvate)" data-entry="C00022" /> <area id="E7700A9D" shape="circle" coords="435,175,4" class="original" href="/entry/C00024" title="C00024 (Acetyl-CoA)" data-entry="C00024" /> <area id="0170102E" shape="circle" coords="500,256,4" class="original" href="/entry/C00332" title="C00332 (Acetoacetyl-CoA)" data-entry="C00332" /> <area id="DD703D01" shape="circle" coords="673,175,4" class="original" href="/entry/C00118" title="C00118 (D-Glyceraldehyde 3-phosphate)" data-entry="C00118" /> <area id="DD7046E8" shape="circle" coords="673,325,4" class="original" href="/entry/C11434" title="C11434 (2-C-Methyl-D-erythritol 4-phosphate)" data-entry="C11434" /> <area id="DC70470B" shape="circle" coords="673,394,4" class="original" href="/entry/C11435" title="C11435 (4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol)" data-entry="C11435" /> <area id="DB704BFC" shape="circle" coords="673,463,4" class="original" href="/entry/C11436" title="C11436 (2-Phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol)" data-entry="C11436" /> <area id="DA7050ED" shape="circle" coords="673,532,4" class="original" href="/entry/C11453" title="C11453 (2-C-Methyl-D-erythritol 2,4-cyclodiphosphate)" data-entry="C11453" /> <area id="D97055DE" shape="circle" coords="673,601,4" class="original" href="/entry/C11811" title="C11811 (1-Hydroxy-2-methyl-2-butenyl 4-diphosphate)" data-entry="C11811" /> <area id="E7701484" shape="circle" coords="435,325,4" class="original" href="/entry/C00356" title="C00356 ((S)-3-Hydroxy-3-methylglutaryl-CoA)" data-entry="C00356" /> <area id="E67014A7" shape="circle" coords="435,394,4" class="original" href="/entry/C00418" title="C00418 ((R)-Mevalonate)" data-entry="C00418" /> <area id="E5701998" shape="circle" coords="435,463,4" class="original" href="/entry/C01107" title="C01107 ((R)-5-Phosphomevalonate)" data-entry="C01107" /> <area id="E4701E89" shape="circle" coords="435,532,4" class="original" href="/entry/C01143" title="C01143 ((R)-5-Diphosphomevalonate)" data-entry="C01143" /> <area id="F2700B38" shape="circle" coords="398,681,4" class="original" href="/entry/C02321" title="C02321 (cis-1,4-Polyisoprene)" data-entry="C02321" /> <area id="DE703CD4" shape="circle" coords="554,681,4" class="original" href="/entry/C00129" title="C00129 (Isopentenyl diphosphate)" data-entry="C00129" /> <area id="D9705606" shape="circle" coords="673,681,4" class="original" href="/entry/C00235" title="C00235 (Dimethylallyl diphosphate)" data-entry="C00235" /> <area id="D4708789" shape="circle" coords="822,681,4" class="original" href="/entry/C16521" title="C16521 (Isoprene)" data-entry="C16521" /> <area id="E2705AFC" shape="circle" coords="673,770,4" class="original" href="/entry/C00341" title="C00341 (Geranyl diphosphate)" data-entry="C00341" /> <area id="DE7041F7" shape="circle" coords="673,256,4" class="original" href="/entry/C11437" title="C11437 (1-Deoxy-D-xylulose 5-phosphate)" data-entry="C11437" /> <area id="EB702D8E" shape="circle" coords="435,849,4" class="original" href="/entry/C16826" title="C16826 (2-cis,6-trans-Farnesyl diphosphate)" data-entry="C16826" /> <area id="7DE1A685" shape="circle" coords="253,1248,4" class="original" href="/entry/C04574" title="C04574 (di-trans,poly-cis-Undecaprenyl diphosphate)" data-entry="C04574" /> <area id="7E45D885" shape="circle" coords="673,1248,4" class="original" href="/entry/C17432" title="C17432 (all-trans-Decaprenyl diphosphate)" data-entry="C17432" /> <area id="EB703284" shape="circle" coords="435,929,4" class="original" href="/entry/C00448" title="C00448 (trans,trans-Farnesyl diphosphate)" data-entry="C00448" /> <area id="7C45D37B" shape="circle" coords="673,1126,4" class="original" href="/entry/C04216" title="C04216 (all-trans-Heptaprenyl diphosphate)" data-entry="C04216" /> <area id="7D45D399" shape="circle" coords="673,1187,4" class="original" href="/entry/C04146" title="C04146 (all-trans-Octaprenyl diphosphate)" data-entry="C04146" /> <area id="78903D8F" shape="circle" coords="914,1112,4" class="original" href="/entry/C04145" title="C04145 (all-trans-Nonaprenyl diphosphate)" data-entry="C04145" /> <area id="7B45CE8F" shape="circle" coords="673,1065,4" class="original" href="/entry/C01230" title="C01230 (all-trans-Hexaprenyl diphosphate)" data-entry="C01230" /> <area id="DF70650B" shape="circle" coords="673,997,4" class="original" href="/entry/C00353" title="C00353 (Geranylgeranyl 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