CINXE.COM

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href="/alnylam-netherlands">Nederlands</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--961 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Portugal</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-portugal">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--962 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Espagne</div> </span><span class="link-text"> <div class="field field--name-field-link1 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</section> </div> </div> </div> </div> <div id="clp-whole-header-top" class="container-fluid"> <div class="site-branding-menu-wrapper .row"> <div class="col-sm-4 site-branding"> <div class="clp-header-top_left"> <div class="region region-clp-header-top-left"> <section id="block-clplogo" class="block block-block-content block-block-contentbb568d43-f6bc-492d-b5aa-ecead699fbce clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><p><img alt="Alnylam® Pharmaceuticals Logo" src="/themes/custom/alnylam/logo.svg" /></p> </div> </section> </div> </div> </div> <div class="col-sm-8 menu"> <div class="row secondary-menu"> <div class="clp-header-right-top"> <div class="region region-clp-header-right-top"> <section id="block-secondarymenuclpluxembourgfrench" class="block block-block-content block-block-content63580917-c620-4a03-a35c-6afe9ade53d1 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><ul class="clp-secondary-menu"><li><a data-colorbox-inline=".cta-header-secondary-menu-Investisseurs">Investisseurs</a></li> <li><a data-colorbox-inline=".cta-header-secondary-menu-Carrières">Carrières</a></li> </ul><div class="popup-content" style="display:none; background:#fff; padding:opx;"> <div class="cta-header-secondary-menu-Investisseurs popup-content" style="display:none; background:#fff;"> <h2 class="text-align-center">REDIRECTION EN COURS</h2> <p class="text-align-center">Vous quittez le site www.alnylam.lu et allez être redirigé vers notre site international (www.alnylam.com) dont le contenu est en anglais.</p> <p class="text-align-center"><a class="button-more text-center" href="https://investors.alnylam.com/">CONTINUER</a></p> </div> </div> <div class="popup-content" style="display:none; background:#fff; padding:opx;"> <div class="cta-header-secondary-menu-Carrières popup-content" style="display:none; background:#fff;"> <h2 class="text-align-center">REDIRECTION EN COURS</h2> <p class="text-align-center">Vous quittez le site www.alnylam.lu et allez être redirigé vers notre site international (www.alnylam.com) dont le contenu est en anglais.</p> <p class="text-align-center"><a class="button-more text-center" href="/careers/">CONTINUER</a></p> </div> </div> </div> </section> <section id="block-language-4" class="block block-block-content block-block-content5a7dc698-6efe-4c02-a3cd-adb2377d4faf clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="language block" id="language-switcher-icon">language<i class="fas fa-angle-down"></i></div> </div> </section> </div> </div> </div> <div class="row ext-cta"> <div class="clp-header-right-bottom"> <div class="region region-clp-header-right-bottom"> <section id="block-clpheaderblockforluxembourgfrench" class="block block-block-content block-block-content76eb3bb3-c080-42db-8e3a-09b4c11c60e0 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><p><a data-colorbox-inline=".cta-header-luxembourg-french">Visiter le site international d’Alnylam (en anglais) ›</a></p> <div class="popup-content" style="display:none; background:#fff; padding:opx;"> <div class="cta-header-luxembourg-french popup-content" style="display:none; background:#fff;"> <h2 class="text-align-center">REDIRECTION EN COURS</h2> <p class="text-center text-align-center">Vous quittez le site www.alnylam.lu et allez être redirigé vers notre site international (www.alnylam.com) dont le contenu est en anglais.</p> <p class="text-align-center"><a class="button-more text-center" href="/">CONTINUER</a></p> </div> </div> </div> </section> </div> </div> </div> <div class="clp-language-switcher-block-wrapper"> <div class="clp-language-switcher-block"> <div class="region region-clp-header-language-block"> <section id="block-languageswitcherforclpluxembourgfrench-2" class="block block-block-content block-block-content18d8e3a1-6351-4554-b975-689722a7c0e1 clearfix"> <div class="field field--name-field-language-link field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--947 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Global</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--948 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Autriche</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-austria">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--949 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Belgique</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-belgium-dutch">Nederlands</a></div> <div class="field--item"><a href="/alnylam-belgium-french">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--950 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Brésil</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.com.br/">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--951 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Canada</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français</a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--952 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">République tchèque</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-czech-republic">Čeština</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--953 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Danemark</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-denmark">Dansk</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--954 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">France </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.fr/">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--955 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Allemagne</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.de/">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--956 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Irlande</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-ireland">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--957 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italie</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--958 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Japon</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.jp/">Japanese</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--959 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Luxembourg</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-luxembourg-french">Français</a></div> <div class="field--item"><a href="/alnylam-luxembourg-german">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--960 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Pays-Bas</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-netherlands">Nederlands</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--961 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Portugal</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-portugal">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--962 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Espagne</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-espana">Español</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--963 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Suède</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-sverige">Svenska</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--964 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Suisse</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-switzerland-french">Français</a></div> <div class="field--item"><a href="/alnylam-switzerland-german">Deutsch</a></div> <div class="field--item"><a href="/alnylam-switzerland-italian">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--965 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Taïwan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-taiwan">Traditional Chinese</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--966 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Royaume-Uni</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> </div> </div> </header> <div id="maindiv" class="container-fluid"> <main id="midcontent-area" class="column main-content"> <div id="content"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="694" role="article" about="/alnylam-luxembourg-french" class="clp full clearfix"> <div class="content"> <div class="field field--name-field-add-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--banner-with-text paragraph-id--1388 paragraph--view-mode--default"> <div class="paragraph paragraph--type--banner-with-text paragraph-id--1388 paragraph--view-mode--default"> <div id="simple-banner-with-text-wrapper" style="background: url(/sites/default/files/2022-04/header_slider_belgium_french_0.jpg); background-size: cover; background-repeat: no-repeat;"> <div class="text-wrapper" style="width:1130px;margin:auto;"> <div class="upper-text"> <h2>À ceux qui déclarent que c’est « impossible, illusoire ou irréaliste, » nous répondons que nous</h2> <h1>Relevons Le Défi</h1> <p>Nous développons actuellement une nouvelle classe de médicaments appelés traitements ARNi qui, selon nous, peuvent potentiellement transformer la vie des personnes atteintes de maladies rares.</p> </div> </div> </div> <div class="mobile-upper-text"> <h2>À ceux qui déclarent que c’est « impossible, illusoire ou irréaliste, » nous répondons que nous</h2> <h1>Relevons Le Défi</h1> <p>Nous développons actuellement une nouvelle classe de médicaments appelés traitements ARNi qui, selon nous, peuvent potentiellement transformer la vie des personnes atteintes de maladies rares.</p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-banner-overlay paragraph-id--1390 paragraph--view-mode--default"> <div id="clp-banner-overlay"> <div class="banner-text-wrapper" style="width:1130px; margin:auto;"> <div class="text-box"> <section> <h1 class="text-align-center"><strong>À L’AVANT-GARDE DU CHANGEMENT</strong></h1> <p class="text-align-center">Alnylam conduit la transformation de l’ARN interférence (ARNi) en une nouvelle classe de médicaments destinés à des patients disposant d’options de traitement limitées ou inadaptées. Basés sur des données scientifiques récompensées d’un Prix Nobel, les traitements ARNi constituent une approche pour le traitement d'un large éventail de maladies graves et invalidantes.</p> <p class="text-align-center">Créée en 2002, la société Alnylam concrétise une vision audacieuse selon laquelle des possibilités scientifiques peuvent devenir une réalité en s’appuyant sur une solide plateforme de découverte et un large portefeuille de médicaments expérimentaux. Parmi eux, cinq produits ayant atteint un stade avancé de développement et quatre produits approuvés aux Etats-Unis et dans l'Union européenne.</p> </section> <div class="counter-box"> <h3 class="text-center">Alnylam by the Numbers</h3> <div class="row"> <div class="col-sm-2"> <h1 class="text-align-center">><span>1k</span></h1> <p class="count-text text-align-center">Employés</p> </div> <div class="col-sm-2"> <h1 class="text-align-center"><span>19</span></h1> <p class="count-text text-align-center">Pays</p> </div> <div class="col-sm-2"> <h1 class="text-align-center"><span>11</span></h1> <p class="count-text text-align-center">Programmes ayant actuellement atteint le stade de développement clinique</p> </div> <div class="col-sm-2"> <h1 class="text-align-center"><span>4</span></h1> <p class="count-text text-align-center">Produits approuvés</p> </div> <div class="col-sm-2"> <h1 class="text-align-center">><span>35</span></h1> <p class="count-text text-align-center">Études cliniques à ce jour</p> </div> <div class="col-sm-2"> <h1 class="text-align-center">><span>8</span></h1> <p class="count-text text-align-center">Ans durée d’exposition la plus longue</p> </div> </div> <p class="text-center margin-top-24px"><em>Mise à jour en juin 2022</em></p> </div> </div> </div> <div class=" popup-content" style="display:none; background:#fff;"> <div class="field field--name-field-pop-up-field field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-full-bleed-bg paragraph-id--1392 paragraph--view-mode--default"> <div class="paragraph paragraph--type--clp-full-bleed-bg paragraph-id--1392 paragraph--view-mode--default"> <div id="clp-full-bleed-bg" style="background: url(/sites/default/files/2022-01/cta_rnai_6.jpg); background-size: cover; background-repeat: no-repeat;"> <div class="text-wrapper" style="width:900px;margin:auto;"> <h1 class="text-align-center"><strong>ARNi : UNE INNOVATION DANS LE DOMAINE DE LA BIOLOGIE QUI S’APPUIE SUR DES RECHERCHES RÉCOMPENSÉES PAR UN PRIX NOBEL</strong></h1> <p class="text-align-center">L’ARN interférence (ARNi) constitue une percée dans la compréhension de la façon dont les gènes sont régulés dans les cellules. C’est également une approche totalement nouvelle appliquée à la découverte et au développement de médicaments. Le Prix Nobel 2006 de physiologie ou de médecine, décerné à Craig Mello et Andrew Fire, a reconnu l’importance de l’ARNi comme une découverte scientifique majeure.</p> <p class="text-align-center"><a data-colorbox-inline=".cta-full-bleed-luxembourg-french">En savoir plus ›</a></p> </div> <div class="cta-full-bleed-luxembourg-french popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-pop-up-content field--type-entity-reference-revisions field--label-hidden field--item"> <div> <h2 class="text-center">REDIRECTION EN COURS</h2> <h4>Vous quittez le site www.alnylam.lu et allez être redirigé vers notre site international (www.alnylam.com) dont le contenu est en anglais.</h4> <p class="text-center"> <a class="button-more" href="/our-science/the-science-of-rnai" target= "_blank">CONTINUER</a> </p> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-html-background paragraph-id--1394 paragraph--view-mode--default"> <div id="clp-html-content-background" style="background-color:#f8f8f8;"> <div class="content-wrapper" style="width:1130px; margin:auto; "> <div class="clp-html-background-desc"> <h2 class="text-align-center"><strong>NOTRE PRIORITÉ</strong></h2> <p class="text-align-center">L’ensemble de nos traitements RNAi expérimentaux visent à traiter des maladies dont les besoins médicaux ne sont pas satisfaits et qui s’inscrivent dans le cadre de 4 domaines thérapeutiques stratégiques (STArs, Strategic Therapeutic Areas) : médicaments génétiques, maladies cardio-métaboliques, maladies infectieuses et maladies du système nerveux central (SNC) et oculaires.</p> <p class="text-align-center"> </p> <p class="text-align-center">Nos produits approuvés à l'intention des patients dans l'Union européenne traitent les neuropathies amyloïdes héréditaires (NAH) à transthyrétine (TTR), la porphyrie hépatique aiguë (PHA), et l'hyperoxalurie primitive (HP). Nos produits thérapeutiques ayant atteint un stade avancé (Phase 2 - Phase 3) de développement se concentrent sur le traitement des amyloses TTR héréditaires (hATTR), de l’hémophilie et des troubles rares de la coagulation, de l’hypercholestérolémie et des maladies liées à un déficit en complément.</p> </div> <div class=" popup-content" style="display:none; background:#fff; overflow:hidden;"> <div class="field field--name-field-html-pop-up field--type-entity-reference-revisions field--label-hidden field--item"> <div> </div> </div> </div> </div> <div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--clp-left-img-text paragraph-id--1396 paragraph--view-mode--default"> <div id="clp-left-img-text"> <div class="img-text-wrapper" style="width:1130px; margin:auto;"> <div class="img-box"> <div class="field field--name-field-upload-image field--type-image field--label-hidden field--item"> <img src="/sites/default/files/2023-05/join_our_team_clps_tptwa_5.png" width="751" height="435" alt="join_our_team_clps_tptwa" loading="lazy" typeof="foaf:Image" class="img-responsive" /> </div> </div> <div class="text-box"> <h2>RE<strong>JOINDRE NOTRE ÉQUIPE</strong></h2> <p>Alors que nous nous efforçons d’atteindre notre but, à savoir devenir une entreprise commerciale pouvant fournir des médicaments aux patients de façon indépendante, nous recherchons des personnes possédant des compétences, expériences, origines et cultures diverses pour nous aider à créer une équipe de classe internationale. 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