Cassia angustifolia and tacrolimus interaction in a liver transplant patient, a case report

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="NJfsog3Dg7YxXAKGX5ZtsIgrDYLfesYhcfjw2QMCVhR9H7jBD1Ik3kWLok9JDMBV"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="NJfsog3Dg7YxXAKGX5ZtsIgrDYLfesYhcfjw2QMCVhR9H7jBD1Ik3kWLok9JDMBV"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="NJfsog3Dg7YxXAKGX5ZtsIgrDYLfesYhcfjw2QMCVhR9H7jBD1Ik3kWLok9JDMBV"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="NJfsog3Dg7YxXAKGX5ZtsIgrDYLfesYhcfjw2QMCVhR9H7jBD1Ik3kWLok9JDMBV"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="38657592"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="https://doi.org/10.1111/bcp.16079" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3058&itool=Abstract-def&log$=linkouticon&uid=38657592&db=pubmed&nlmid=7503323" title="See full text options at Wiley" data-ga-category="full_text" data-ga-action="Wiley" data-ga-label="38657592" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7388-63-JWS-SH-PubMed-BJCP.gif" alt="full text provider logo"><span class="text"> Wiley </span></a> </div> </div> <div class="short-view"> <a href="#" class="full-text-links-button full-text-links-dialog-trigger"> Full text links </a> </div> </div> <div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/38657592/citations/" 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id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="NJfsog3Dg7YxXAKGX5ZtsIgrDYLfesYhcfjw2QMCVhR9H7jBD1Ik3kWLok9JDMBV"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 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Reports</div> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="British journal of clinical pharmacology" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal British journal of clinical pharmacology" data-pinger-ignore> Br J Clin Pharmacol </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal British journal of clinical pharmacology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Br+J+Clin+Pharmacol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Br+J+Clin+Pharmacol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Br J 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class="heading-title"> Cassia angustifolia and tacrolimus interaction in a liver transplant patient, a case report </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Beltr%C3%A1-Pic%C3%B3+I&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Iván Beltrá-Picó">Iván Beltrá-Picó</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy, Clinical Pharmacokinetics Unit, Dr.Balmis General University Hospital, Alicante, Spain." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=D%C3%ADaz-Gonz%C3%A1lez+M&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Marcos Díaz-González">Marcos Díaz-González</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy, Clinical Pharmacokinetics Unit, Dr.Balmis General University Hospital, Alicante, Spain." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nalda-Molina+R&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ricardo Nalda-Molina">Ricardo Nalda-Molina</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy and Pharmaceutical Technology, Miguel Hernandez University of Elche, Alicante, Spain." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ramon-Lopez+A&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Amelia Ramon-Lopez">Amelia Ramon-Lopez</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy and Pharmaceutical Technology, Miguel Hernandez University of Elche, Alicante, Spain." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pascual-Bartolom%C3%A9+S&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sonia Pascual-Bartolomé">Sonia Pascual-Bartolomé</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Miralles-Maci%C3%A0+CF&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Cayetano F Miralles-Macià">Cayetano F Miralles-Macià</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rodr%C3%ADguez-Soler+M&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="María Rodríguez-Soler">María Rodríguez-Soler</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=M%C3%A1s-Serrano+P&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patricio Más-Serrano">Patricio Más-Serrano</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy, Clinical Pharmacokinetics Unit, Dr.Balmis General University Hospital, Alicante, Spain." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/38657592/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Pharmacy, Clinical Pharmacokinetics Unit, Dr.Balmis General University Hospital, Alicante, Spain.</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2" ><sup class="key">2</sup> Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.</li> <li data-affiliation-id="full-view-affiliation-3" id="full-view-affiliation-3" ><sup class="key">3</sup> Pharmacy and Pharmaceutical Technology, Miguel Hernandez University of Elche, Alicante, Spain.</li> <li data-affiliation-id="full-view-affiliation-4" id="full-view-affiliation-4" ><sup class="key">4</sup> Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38657592</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1111/bcp.16079&id_type=DOI" href="https://doi.org/10.1111/bcp.16079" data-ga-category="full_text" data-ga-action="DOI" > 10.1111/bcp.16079 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <div class="publication-type" >Case Reports</div> <h1 class="heading-title"> Cassia angustifolia and tacrolimus interaction in a liver transplant patient, a case report </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Iván Beltrá-Picó</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Br J Clin Pharmacol<span class="citation-separator">.</span> </span> <span class="date"> <span class="citation-year">2024 Jul</span><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/38657592/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div 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Unit, Dr.Balmis General University Hospital, Alicante, Spain." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=D%C3%ADaz-Gonz%C3%A1lez+M&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Marcos Díaz-González">Marcos Díaz-González</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy, Clinical Pharmacokinetics Unit, Dr.Balmis General University Hospital, Alicante, Spain." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nalda-Molina+R&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ricardo Nalda-Molina">Ricardo Nalda-Molina</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy and Pharmaceutical Technology, Miguel Hernandez University of Elche, Alicante, Spain." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ramon-Lopez+A&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Amelia Ramon-Lopez">Amelia Ramon-Lopez</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy and Pharmaceutical Technology, Miguel Hernandez University of Elche, Alicante, Spain." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pascual-Bartolom%C3%A9+S&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sonia Pascual-Bartolomé">Sonia Pascual-Bartolomé</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Miralles-Maci%C3%A0+CF&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Cayetano F Miralles-Macià">Cayetano F Miralles-Macià</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rodr%C3%ADguez-Soler+M&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="María Rodríguez-Soler">María Rodríguez-Soler</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=M%C3%A1s-Serrano+P&cauthor_id=38657592" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Patricio Más-Serrano">Patricio Más-Serrano</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Pharmacy, Clinical Pharmacokinetics Unit, Dr.Balmis General University Hospital, Alicante, Spain." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Pharmacy, Clinical Pharmacokinetics Unit, Dr.Balmis General University Hospital, Alicante, Spain.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Pharmacy and Pharmaceutical Technology, Miguel Hernandez University of Elche, Alicante, Spain.</li> <li data-affiliation-id="short-view-affiliation-4" id="short-view-affiliation-4" ><sup class="key">4</sup> Hepatology and Liver Unit, Dr. Balmis General University Hospital, Alicante, Spain.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38657592</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1111/bcp.16079&id_type=DOI" href="https://doi.org/10.1111/bcp.16079" data-ga-category="full_text" data-ga-action="DOI" > 10.1111/bcp.16079 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/38657592/citations/" data-citation-style="nlm" data-pubmed-format-link="/38657592/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Cassia angustifolia is a species of plant from the Senna family that has traditionally been used as a laxative in different herbal products and commercial medicines. Even though there are few documented drug-plant interactions, the use of C. angustifolia with different drugs may have additive effects, such as with other laxatives or potassium-depleting diuretics. Its use also increases peristalsis which, may reduce drug absorption. The combination with digoxin has been associated with an increased risk of digoxin toxicity, probably due to an increase in plasma digoxin concentrations and hypokalaemia. We present a case with supratherapeutic trough concentration of tacrolimus, an immunosuppressive agent, and a herbal product in a liver transplant patient after concomitant intake of tacrolimus and a herbal product based on C. angustifolia, suggesting a possible drug-lant interaction through by P-glycoprotein. We observed an increase in the patient's blood concentration 2.8-fold and the area under the curve at steady state 2.1-fold. This interaction could be of clinical relevance, given the dose-dependent side effects of tacrolimus, such as nephrotoxicity, neurotoxicity, hypertension, hyperglycaemia, or electrolyte alterations. </p> </div> <p> <strong class="sub-title"> Keywords: </strong> food/herbal drug interactions; immunosuppression; liver; pharmacokinetic–pharmacodynamic; transplantation. </p> </div> <p class="copyright" id="copyright"> © 2024 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. </p> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/26976646/" ref="article_id=26976646&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="26976646" data-ga-label=""> A Pilot Study of the Pharmacokinetics of the Modified-Release Once-Daily Tacrolimus Formulation Administered to Living-Donor Liver Transplant Recipients. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Song GW, Lee SG, Hwang S, Kim KH, Kim WJ, Sin MH, Yoon YI, Tak EY.</span> <span class="docsum-authors short-authors">Song GW, et al.</span> <span class="docsum-journal-citation full-journal-citation">Exp Clin Transplant. 2016 Aug;14(4):412-8. doi: 10.6002/ect.2015.0227. 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Population pharmacokinetic model and Bayesian estimator for two tacrolimus formulations – twice daily Prograf®and once daily Advagraf®. Br J Clin Pharmacol. 2011;71(3):391‐402. doi:10.1111/j.1365‐2125.2010.03837.x </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing; 2023. <a class="external-link-urlize" href="https://www.R-project.org/" rel="nofollow noopener" target="_blank">https://www.R-project.org/</a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Rstudio: Posit Team. RStudio: Integrated Development Environment for R. Posit Software, PBC; 2023. <a class="external-link-urlize" href="http://www.posit.co/" rel="nofollow noopener" target="_blank">http://www.posit.co/</a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Ulbricht C, Conquer J, Costa D, et al. An evidence‐based systematic review of senna (Cassia senna) by the Natural Standard Research Collaboration. J Diet Suppl. 2011;8(2):189‐238. doi:10.3109/19390211.2011.573186 </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Waltenberger B, Avula B, Ganzera M, Khan IA, Stuppner H, Khan SI. Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco‐2 monolayers—an in vitro model for intestinal absorption. 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Cassia angustifolia and tacrolimus interaction in a liver transplant patient, a case report - PubMed