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Saturday, March 15, 2025</div><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_SCIENCE" target="_blank" href="https://clarivate.com/news/bioworld-by-clarivate-releases-comprehensive-2024-year-in-review/">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/705938-explore-bioworlds-comprehensive-infographics-collection">Breaking News: Explore BioWorld’s comprehensive infographics collection</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/705938-explore-bioworlds-comprehensive-infographics-collection">Breaking News: Explore BioWorld’s comprehensive infographics collection</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a></section><section class="featured-stories__wrapper -primary-4 --secondary-4"><div class="featured-stories__primary "><section class="featured-stories "> <div class="featured-stories__items-wrapper"><ul class="featured-stories__items featured-stories__items-1"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><figure class="featured-stories__image"><a class="featured-stories__thumbnail-link" data-eventname="featured-stories" data-eventcategory="click" data-eventaction="featured-stories-image" data-eventlabel="https://www.bioworld.com/articles/718291-in-hiv-draining-the-reservoir-means-understanding-the-brain" href="https://www.bioworld.com/articles/718291-in-hiv-draining-the-reservoir-means-understanding-the-brain"><img class="featured-stories__image-thumb" alt="Illustration of magnifying glass inspecting brain" title="Illustration of magnifying glass inspecting brain" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Neurology-brain-magnifying-glass.jpg?height=355&t=1741964843&width=640" /></a></figure><div class="featured-stories__details featured-stories__details-1"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718291-in-hiv-draining-the-reservoir-means-understanding-the-brain">In HIV, draining the reservoir means understanding the brain</a></h1><div class="featured-stories__teaser">The availability of effective antiretroviral therapy has lowered the risk, and the severity, of neural sequelae of HIV infection. “Early in the HIV pandemic, approximately 15% of people with HIV had dementia and or encephalitis,” Howard Fox told his audience. “Fortunately, with treatment, the prevalence of these severe disorders has been greatly lowered. But there is persistence of what are called more minor disorders – which are not minor if you have them.”</div></div></article> </li> </ul><ul class="featured-stories__items featured-stories__items-2"> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718292-cgas-inhibition-suppresses-tumor-growth-and-sensitizes-dlbcl-cell-lines-to-ferroptosis">cGAS inhibition suppresses tumor growth and sensitizes DLBCL cell lines to ferroptosis</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718293-sutro-prioritizes-preclinical-adc-programs">Sutro prioritizes preclinical ADC programs</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718294-orka-002-potential-best-in-class-anti-il-17a-f-monoclonal-antibody-with-extended-half-life">ORKA-002: potential best-in-class anti-IL-17A/F monoclonal antibody with extended half-life</a></h1></article> </li> </ul></div> </section></div><div class="featured-stories__secondary"><section class="featured-stories "> <ul class="featured-stories__items"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718291-in-hiv-draining-the-reservoir-means-understanding-the-brain">In HIV, draining the reservoir means understanding the brain</a></h1><div class="featured-stories__teaser">The availability of effective antiretroviral therapy has lowered the risk, and the severity, of neural sequelae of HIV infection. “Early in the HIV pandemic, approximately 15% of people with HIV had dementia and or encephalitis,” Howard Fox told his audience. “Fortunately, with treatment, the prevalence of these severe disorders has been greatly lowered. But there is persistence of what are called more minor disorders – which are not minor if you have them.”</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718292-cgas-inhibition-suppresses-tumor-growth-and-sensitizes-dlbcl-cell-lines-to-ferroptosis">cGAS inhibition suppresses tumor growth and sensitizes DLBCL cell lines to ferroptosis</a></h1><div class="featured-stories__teaser">Researchers from Soochow University and affiliated organizations presented data from a study that aimed to investigate the role of cyclic GMP-AMP synthase (cGAS) in tumorigenesis and tumor progression.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718293-sutro-prioritizes-preclinical-adc-programs">Sutro prioritizes preclinical ADC programs</a></h1><div class="featured-stories__teaser">Sutro Biopharma Inc. has announced plans to prioritize its three wholly owned preclinical programs in its next-generation antibody-drug conjugate (ADC) pipeline, while deprioritizing additional investment into development of luveltamab tazevibulin across all indications.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718294-orka-002-potential-best-in-class-anti-il-17a-f-monoclonal-antibody-with-extended-half-life">ORKA-002: potential best-in-class anti-IL-17A/F monoclonal antibody with extended half-life</a></h1><div class="featured-stories__teaser">Patients with psoriatic arthritis exhibit high levels of both IL-17A and IL-17F cytokines in the synovium. Bimekizumab, a biologic that targets both IL-17A and IL-17F, was recently approved for the treatment of plaque psoriasis and psoriatic arthritis.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/712279-other-news-to-note-for-march-14-2025">Other news to note for March 14, 2025</a></h1><div class="featured-stories__teaser">Additional early-stage research and drug discovery news in brief.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718295-apg-777-plus-apg-990-combination-results-in-superior-suppression-of-inflammatory-cytokines">APG-777 plus APG-990 combination results in superior suppression of inflammatory cytokines</a></h1><div class="featured-stories__teaser">APG-777 is an anti-IL-13 humanized monoclonal antibody (mAb) designed to block Th2 inflammatory signaling mediated by the IL-13Rα1/IL-4Rα complex, while APG-990 is a fully human anti-OX40L mAb that that blocks type 1/2/3 inflammatory signaling. Apogee Therapeutics Inc. is studying the combination effects of APG-777 and APG-990 as potential therapy for atopic dermatitis (AD).</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718296-sotio-exercises-option-to-license-synaffix-technology-for-adc-programs">Sotio exercises option to license Synaffix technology for ADC programs</a></h1><div class="featured-stories__teaser">Sotio Biotech AS is exercising an option under a license and option agreement to obtain a license to Synaffix BV’s technology to develop two bispecific antibody-drug conjugate (ADC) programs  for solid tumors.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/718303-the-scripps-research-institute-patents-new-opioid-receptor-antagonists">The Scripps Research Institute patents new κ-opioid receptor antagonists</a></h1><div class="featured-stories__teaser">The Scripps Research Institute has disclosed κ-opioid receptor antagonists reported to be useful for the treatment of depression, anxiety, schizophrenia, obesity, migraine, substance abuse and dependence, epilepsy and eating disorders, among others.</div></article> </li> </ul> </section></div><div class="news-service articles-by-site-placement-tax"><section class="featured-stories-by-site-placement__wrapper"><section class="featured-stories-by-site-placement "> <div class="featured-stories-by-site-placement__items-wrapper"><ul class="featured-stories-by-site-placement__items featured-stories-by-site-placement__items-1"> <li class="featured-stories-by-site-placement__item"> <article 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href="https://www.bioworld.com/articles/718297-grant-supports-evaluation-of-myrobalans-gpr17-antagonist-for-progressive-ms"><img class="featured-stories-by-site-placement__image-thumb" alt="Multiple sclerosis" title="Multiple sclerosis" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Multiple-sclerosis.png?height=146&t=1607460204&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/718304-charles-university-and-mfmer-divulge-new-dna-topoisomerase-ii-inhibitors-to-treat-cardiotoxicity">Charles University and MFMER divulge new DNA topoisomerase II β inhibitors to treat cardiotoxicity</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/718305-selene-therapeutics-describes-new-brain-permeable-dhodh-inhibitors">Selene Therapeutics describes new brain permeable DHODH inhibitors</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/718298-recent-published-data-link-mir-708-5p-with-bipolar-disorder">Recent published data link miR-708-5p with bipolar disorder</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/718298-recent-published-data-link-mir-708-5p-with-bipolar-disorder" href="https://www.bioworld.com/articles/718298-recent-published-data-link-mir-708-5p-with-bipolar-disorder"><img class="featured-stories-by-site-placement__image-thumb" alt="Silhouette made of crumpled paper illustrating depression" title="Silhouette made of crumpled paper illustrating depression" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/neurology-depression.png?height=146&t=1589297245&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/718306-new-ebp-inhibitors-disclosed-in-biogen-patent">New EBP inhibitors disclosed in Biogen patent</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/718307-onkure-discovers-new-pi3k-inhibitors">Onkure discovers new PI3Kα inhibitors</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/718299-new-data-link-selenoo-expression-with-melanoma-metastasis">New data link SELENOO expression with melanoma metastasis</a></h1><figure class="featured-stories-by-site-placement__image"><a 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class="bioworld-podcasts-component"><div class="bioworld-podcasts-component__wrapper"><div class="bioworld-podcasts-component__content"><h3 class="bioworld-podcasts-component__headline"><a class="bioworld-podcasts-component__headline-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/54-mega-money-well-spent-mammoth-mergers-fall-short-of-the-dream">BioWorld Insider Podcast</a></h3><div class="bioworld-podcasts-component__body"><img src="https://www.bioworld.com/ext/resources/Podcast-files/play-circle-button.png?1718131949" style="display: inline-block; vertical-align: bottom; margin: 5px 0px 5px 5px; text-align: right; float: right; max-width: calc(100% - 5px); width: 95px;" alt="Play button" data-uuid="YTAtMTE1OTM1" align="right">Billion-dollar biopharma mergers fall short of the dream: Karen Carey, <em>BioWorld</em>’s senior managing editor and chief analyst, crunched the numbers on 21 of the biggest M&As and found very few have been, so far, good deals for the buyer.</div><a class="bioworld-podcasts-component__link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/54-mega-money-well-spent-mammoth-mergers-fall-short-of-the-dream">Listen now</a><div class="bioworld-podcasts-component__adplugg-ad"><div class="adplugg-tag" data-adplugg-zone="bioworld_podcasts_science"></div></div></div></div></section></div><section class="topics-section__wrapper"><div class="topics-section__primary"><section class="topics-section "> <h1 class="topics-section__title"><a class="topics-section__title-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-title" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">Conferences</a></h1><ul class="topics-section__items"> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a 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href="https://www.bioworld.com/articles/718222-first-in-class-oral-immunomodulator-shows-efficacy-in-psoriasis-models"><img class="topics-section__image-thumb" alt="Dry, thick and raised patches on the skin of knees and elbows" title="Dry, thick and raised patches on the skin of knees and elbows" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Dermatologic/Psoriasis-knees-elbow.jpg?height=355&t=1710256689&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/718222-first-in-class-oral-immunomodulator-shows-efficacy-in-psoriasis-models">First-in-class oral immunomodulator shows efficacy in psoriasis models</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/242,520">Dermatologic</a></div><div class="topics-section__teaser">Psoriasis is a chronic, recurrent and inflammatory skin disorder associated with immune system dysregulation. The abnormal immune response led to accelerated skin cell proliferation, resulting in thick plaques and chronic inflammation. The current gold-standard treatment is injectable...</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/718220-sp-38-potently-inhibits-hiv-1-replication-by-inducing-defective-particle-morphology" href="https://www.bioworld.com/articles/718220-sp-38-potently-inhibits-hiv-1-replication-by-inducing-defective-particle-morphology"><img class="topics-section__image-thumb" alt="Transmission electron micrograph of HIV-1 virus particles " title="Transmission electron micrograph of HIV-1 virus particles " width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/NIH-NIAID-HIV-1-virus-particles.jpg?height=355&t=1719502120&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/718220-sp-38-potently-inhibits-hiv-1-replication-by-inducing-defective-particle-morphology">SP-38 potently inhibits HIV-1 replication by inducing defective particle morphology</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/185,520">Conference on Retroviruses and Opportunistic Infections</a></div><div class="topics-section__teaser">It was previously demonstrated that the HIV-1 integrase (IN)-interacting host factor INI1/SMARCB1 binds to HIV-1 IN through its Rpt1 domain of INI1 (INI1-Rpt1) and plays a key role in assembly and particle production.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/718218-dkk1-knockout-mitigates-cell-proliferation-and-invasion-in-tnbc-cells">DKK1 knockout mitigates cell proliferation and invasion in TNBC cells</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="topics-section__teaser">Triple-negative breast cancer (TNBC) is among the most aggressive breast cancer subtypes, with high metastasis and recurrence rates, as well as poor survival. 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Ltd. discovers new androgen receptor degradation inducers</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718232-wee1-inhibitors-disclosed-in-schroedinger-patent">Wee1 inhibitors disclosed in Schroedinger patent</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718231-shenzhen-zhongge-biotechnology-describes-new-irak-4-degradation-inducers">Shenzhen Zhongge Biotechnology describes new IRAK-4 degradation inducers</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718230-shanghai-henlius-biologics-divulges-new-kat6a-and-kat6b-inhibitors">Shanghai Henlius Biologics divulges new KAT6A and KAT6B inhibitors </a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718229-xian-xintong-medicine-research-patents-new-thr-agonists">Xi’an Xintong Medicine Research patents new THR-β agonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718172-lucy-therapeutics-discovers-new-adenosine-receptor-agonists">Lucy Therapeutics discovers new adenosine receptor agonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718171-new-pde4-degradation-inducers-disclosed-in-katalytic-patent">New PDE4 degradation inducers disclosed in Katalytic patent </a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718170-universite-laval-describes-new-17-hsd1-inhibitors">Université Laval describes new 17β-HSD1 inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718169-laekna-pharmaceutical-divulges-new-pi3k-inhibitors-for-breast-cancer">Laekna Pharmaceutical divulges new PI3Kα inhibitors for breast cancer</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718168-korean-researchers-patent-new-raf-1-inhibitors">Korean researchers patent new RAF-1 inhibitors</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">Cancer</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/718219-rakovina-advances-atr-inhibitors-into-preclinical-testing" href="https://www.bioworld.com/articles/718219-rakovina-advances-atr-inhibitors-into-preclinical-testing"><img class="bioworld-biome__image-thumb" alt="Ribbons of digital data" title="Ribbons of digital data" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/AI/AI-network-machine-learning.png?height=355&t=1588275771&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/718219-rakovina-advances-atr-inhibitors-into-preclinical-testing">Rakovina advances ATR inhibitors into preclinical testing</a></h1><div class="bioworld-biome__teaser">Rakovina Therapeutics Inc. has received the first synthesized batch of AI-generated ATR inhibitor compounds developed in collaboration with Variational AI Inc. The companies partnered last year to leverage the Enki generative AI platform for the development of next-generation DNA damage response...</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/718161-pierre-fabre-and-redridge-bio-to-develop-biparatopic-antibody-drug-candidates">Pierre Fabre and Redridge Bio to develop biparatopic antibody drug candidates</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/544,520">Drug design, drug delivery and technologies</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/718160-ina-03-demonstrates-efficacy-in-preclinical-models-of-triple-negative-breast-cancer">INA-03 demonstrates efficacy in preclinical models of triple-negative breast cancer</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/718162-bifunctional-antibody-targeting-t-cell-receptor-is-effective-against-aggressive-prostate-tumors">Bifunctional antibody targeting T-cell receptor is effective against aggressive prostate tumors</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/718158-md-anderson-to-explore-apreas-wee1-kinase-inhibitor-for-hnscc">MD Anderson to explore Aprea’s WEE1 kinase inhibitor for HNSCC</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/217,520">Collaboration</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">More in Cancer</a> </section></div><div class="adplugg-tag" data-adplugg-zone="bioworld_science_promo_1"></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">Infection</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/718217-long-covid-science-is-progressing-though-therapies-have-not-yet-followed" href="https://www.bioworld.com/articles/718217-long-covid-science-is-progressing-though-therapies-have-not-yet-followed"><img class="clinical__image-thumb" alt="Red coronavirus with long shadow" title="Red coronavirus with long shadow" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Coronavirus-with-long-shadow.png?height=355&t=1674598407&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/718217-long-covid-science-is-progressing-though-therapies-have-not-yet-followed">Long COVID science is progressing, though therapies have not yet followed</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/110,520">Science</a></div><div class="clinical__teaser">In 2020, the Conference on Retroviruses and Opportunistic Infections (CROI) was the first scientific conference to move from in-person to virtual due to the COVID-19 pandemic. On the fifth anniversary of the virtual conference, and the pandemic, some of those earliest COVID-19 patients have still...</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/718260-study-looks-to-noncoding-gene-variants-for-new-drug-targets">Study looks to noncoding gene variants for new drug targets</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/129,520">Omics</a></div><div class="clinical__teaser">A new multi-omics approach to unpicking how noncoding gene variants influence the development of common chronic diseases has identified tens of thousands of instances where variants have an impact on gene expression levels and gene splicing, the post-transcriptional modification that allows one...</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/718191-at-croi-hiv-cure-trials-raise-hopes-for-broader-applicability">At CROI, HIV cure trials raise hopes for broader applicability</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/110,520">Science</a></div><div class="clinical__teaser">At the 2025 meeting of the Conference on Retroviruses and Opportunistic Infections (CROI) it was the best of times, it was the worst of times. On the first full day of the conference, reports from the first HIV cure trial conducted in Africa, the RIO trial and others showed that perhaps, a broadly...</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/718139-using-computational-biology-to-develop-pan-h5-vaccine-against-avian-influenza">Using computational biology to develop pan-H5 vaccine against avian influenza</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/718133-at-croi-hiv-cure-trials-raise-hopes-for-broader-applicability">At CROI, HIV cure trials raise hopes for broader applicability</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/110,520">Science</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/718050-new-organ-targeted-antimicrobial-agent-for-the-treatment-of-systemic-infections-and-pyelonephritis">New organ-targeted antimicrobial agent for the treatment of systemic infections and pyelonephritis</a></h1></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717920-merck-sharp-and-dohme-divulges-new-viral-replication-inhibitors">Merck Sharp & Dohme divulges new viral replication inhibitors</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/472,520">Patents</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">More in Infection</a> </section></div></div></section><div class="deals-m-a__wrapper"><section class="deals-m-a "> <h1 class="deals-m-a__title"><a class="deals-m-a__title-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-title" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">Neurology/psychiatric</a></h1><ul class="deals-m-a__items"> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/718163-novel-imidazoline-i2-receptor-ligand-disclosed">Novel imidazoline I2 receptor ligand disclosed </a></h1><div class="deals-m-a__teaser">Researchers from the University of Barcelona and collaborators reported the discovery and preclinical characterization of novel imidazoline I2 receptor ligands (I2-IRs). Among the series, the most potent compound, [I], had a Ki value of 1.05 nM for the I2-IR and no I2/α2 selectivity.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/718146-biogen-patents-new-gpr17-antagonists-for-multiple-sclerosis">Biogen patents new GPR17 antagonists for multiple sclerosis</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Biogen Inc. has disclosed uracil nucleotide/cysteinyl leukotriene receptor (GPR17; P2Y-Like) antagonists with improved brain penetration reported to be useful for the treatment of multiple sclerosis.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/718051-de-novo-mutations-in-ppp2r5c-cause-neurodevelopmental-disorder" href="https://www.bioworld.com/articles/718051-de-novo-mutations-in-ppp2r5c-cause-neurodevelopmental-disorder"><img class="deals-m-a__image-thumb" alt="Brain and DNA" title="Brain and DNA" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/brain-neuro-dna.png?height=355&t=1589297363&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/718051-de-novo-mutations-in-ppp2r5c-cause-neurodevelopmental-disorder">De novo mutations in PPP2R5C cause neurodevelopmental disorder</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/543,520">Biomarkers</a></div><div class="deals-m-a__teaser">Neurodevelopmental disorders related to protein phosphatase 2A (PP2A) have been recently renamed as Houge-Janssens syndrome and they are caused by heterozygous, de novo pathogenic genetic variants in the <em>PPP2R5D</em>, <em>PPP2R1A</em> or <em>PPP2CA</em> genes. The syndrome is characterized by features such as...</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/718045-inflammation-appears-to-cause-mutations-linked-to-ms-progression" href="https://www.bioworld.com/articles/718045-inflammation-appears-to-cause-mutations-linked-to-ms-progression"><img class="deals-m-a__image-thumb" alt="Justin Rubio working in the lab" title="Justin Rubio working in the lab" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-source/Florey-Inst-Justin-Rubio-hero-3-10.jpg?height=355&t=1741616070&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/718045-inflammation-appears-to-cause-mutations-linked-to-ms-progression">Inflammation appears to cause mutations linked to MS progression</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/543,520">Biomarkers</a></div><div class="deals-m-a__teaser">For the first time, researchers have identified that inflammation – long associated with multiple sclerosis (MS) – appears to cause increased mutations that damage neurons linked to MS progression. Researchers at the Florey Institute and the University of Melbourne studied MS brain lesions, which...</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/718107-uk-firm-trimtech-emerges-with-31m-seed-round-for-trim21-bispecifics" href="https://www.bioworld.com/articles/718107-uk-firm-trimtech-emerges-with-31m-seed-round-for-trim21-bispecifics"><img class="deals-m-a__image-thumb" alt="Trimtech Therapeutics’ team" title="Trimtech Therapeutics’ team" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BW-source/2025/Trimtech-Therapeutics-team-3-5.jpg?height=355&t=1741213881&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/718107-uk-firm-trimtech-emerges-with-31m-seed-round-for-trim21-bispecifics">UK firm Trimtech emerges with $31M seed round for TRIM21 bispecifics</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/292,520">Financings</a></div><div class="deals-m-a__teaser">Trimtech Therapeutics closed a £25 million (US$31 million) oversubscribed seed funding round to advance its targeted protein degradation treatments for neurodegenerative and inflammatory diseases.</div></div></article> </li> </ul><a class="deals-m-a__more-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-more-link" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">More in Neurology/psychiatric</a> </section></div><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/250-immune" href="/articles/topic/250-immune">Immune</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718137-preclinical-data-reported-for-astrias-anti-ox40-monoclonal-antibody">Preclinical data reported for Astria’s anti-OX40 monoclonal antibody</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718048-seismic-therapeutic-presents-new-strategy-for-ige-mediated-diseases">Seismic Therapeutic presents new strategy for IgE-mediated diseases</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/718047-half-life-extended-trispecific-anti-peanut-antibody-provides-continuous-protection-from-allergic-reactions">Half-life extended trispecific anti-peanut antibody provides continuous protection from allergic reactions</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717915-thb-335-counteracts-cutaneous-anaphylaxis-in-vivo">THB-335 counteracts cutaneous anaphylaxis in vivo</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717902-irl-201104-shows-efficacy-with-different-routes-of-administration-in-preclinical-models">IRL-201104 shows efficacy with different routes of administration in preclinical models</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717888-blu-808-effectively-inhibits-mast-cell-activation-in-preclinical-models">BLU-808 effectively inhibits mast cell activation in preclinical models</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717886-apg-333-counteracts-type-2-inflammation-with-an-extended-half-life-profile">APG-333 counteracts type 2 inflammation with an extended half-life profile</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717556-in8bio-advances-t-cell-engager-targeting-cd19">In8bio advances γδ T-cell engager targeting CD19</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717555-celldexs-cdx-622-shows-promise-for-inflammatory-disorders">Celldex’s CDX-622 shows promise for inflammatory disorders</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717518-fkbp5-inhibition-ameliorates-inflammation-in-preclinical-multiple-sclerosis">FKBP5 inhibition ameliorates inflammation in preclinical multiple sclerosis</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">Endocrine/metabolic</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/718159-harbour-biomeds-new-elance-therapeutics-takes-aim-at-obesity" href="https://www.bioworld.com/articles/718159-harbour-biomeds-new-elance-therapeutics-takes-aim-at-obesity"><img class="bioworld-biome__image-thumb" alt="Woman measuring her body fat with caliper" title="Woman measuring her body fat with caliper" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Obesity/stomach-weight-loss-caliper-body-fat.jpg?height=355&t=1736785357&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/718159-harbour-biomeds-new-elance-therapeutics-takes-aim-at-obesity">Harbour Biomed’s new Élancé Therapeutics takes aim at obesity</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/273,520">Bispecific antibody</a></div><div class="bioworld-biome__teaser">Harbour Biomed Ltd. has announced the launch of Élancé Therapeutics with an aim to improve the treatment of obesity. 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