CINXE.COM

<!DOCTYPE html> <html class="no-js" lang="en" prefix="og: https://ogp.me/ns#"> <head> <script src="https://sp-library.prod.sp.aws.clarivate.net/oti/latest/index.umd.js"></script> <link href="https://www.bioworld.com/topics/520-bioworld-science" rel="canonical"> <meta charset="utf-8"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="dKOkyLWcSthap+s4VC4r08qRMPFvWlfTI+rtoxxGAYZDvCOSwmrMqz17NmnHtrEs9mwYumRzPhm8nCICvUbCxg==" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta name="timestamp" value="2025-02-17 05:52:33 -0500"> <meta name="description" content="Daily news focused on drug discovery, delivery and preclinical research. Coverage includes: Congress highlights, key studies from peer-reviewed journals, chemical structure images, pharmacology news that delineates drug/receptor and enzyme/target cell interactions, newly reported experimental models, and relationships between genes and diseases to gain insight into underlying biological mechanisms and identify potential new drug targets" /> <meta name="keywords" content="news, patents, congress, biotech, biotechnology, pharma, pharmaceutical, R&D, drugs, drug research, health, cancer, preclinical, financing, science, IND, partnerships, collaborations" /> <link rel="alternate" type="application/xml" title="BioWorld RSS Feed" href="https://www.bioworld.com/rss/articles" /> <meta property="og:title" /> <meta property="og:description" /> <meta property="og:url" /> <meta property="og:type" content="Website" /> <meta content="false" name="has-log-view" /> <title>BioWorld Science: The Daily Drug R&D News Source</title> <link rel="stylesheet" media="screen" href="/stylesheets/application.css?v=1739789553" /> <script src="/javascripts/jade.default.min.js?v=1739789553"></script> <script src="/javascripts/application.js?v=1739789553"></script>  <script>var dataLayer = window.dataLayer || [];</script> <script>let snowplowData = {"event":"SnowplowStructuredEvent","product":"BIOWORLD_SCIENCE"}; fetch('/user/snowplow', { method: 'GET', headers: { 'Content-Type': 'application/json' } }) .then(response => { if (!response.ok) { throw new Error(`HTTP error! status: ${response.status}`); } return response.json(); }) .then(data => { const evt = Object.assign({}, snowplowData, data); console.info('Snowplow Data:', evt); // Handle the fetched data dataLayer.push(evt); }) .catch(error => { console.error('Error fetching snowplow data:', error); // Handle any errors });</script><script>dataLayer.push({"id":520,"topics":["BioWorld Science"],"title":"BioWorld Science","page_type":["topics"],"date_posted":"07/06/2020","gated":false,"registered":true});</script> <script>typeof window.dataLayer[0] === 'object' && !('page_type' in window.dataLayer[0]) && window.dataLayer.push({"id":520,"topics":["BioWorld Science"],"title":"BioWorld Science","page_type":["topics"],"date_posted":"07/06/2020","gated":false,"registered":true});</script>   <script> //<![CDATA[ (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-5ZV86V9'); //]]> </script>  <script> window.epub = window.epub || {}; window.epub['AD_HISTORY_ENABLED'] = false; </script> <link rel="apple-touch-icon" sizes="180x180" href="/icons/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="/icons/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="/icons/favicon-16x16.png"> <link rel="manifest" href="/icons/site.webmanifest"> <link rel="mask-icon" href="/icons/safari-pinned-tab.svg" color="#5bbad5"> <link rel="shortcut icon" href="/icons/favicon.ico"> <meta name="msapplication-TileColor" content="#00aba9"> <meta name="msapplication-config" content="/icons/browserconfig.xml"> <meta name="theme-color" content="#ffffff"><script> var googletag = { cmd: [] }; var targeting = window.targeting = {"id":"520","tags":["BioWorld Science"],"taxonomy":["BioWorld Science"],"taxonomy_id":[520],"sponsored":"false","page_type":["topics"],"keyword":[],"reg_user":"false","page_name":"520-bioworld-science","search_terms":"","url":"/topics/520-bioworld-science","site_env":"production"}; </script> <script> (function(ac) { var d = document, s = 'script', id = 'adplugg-adjs'; var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.async = 1; js.src = '//www.adplugg.com/serve/' + ac + '/js/1.1/ad.js'; fjs.parentNode.insertBefore(js, fjs); }('A48225833')); </script><script>if (typeof Oti !== "undefined" && typeof Oti.OtiService !== "undefined") { $.post('/user/pendo', function(data) { const pendoVisitor = data.visitor const pendoAccount = Object.keys(pendoVisitor).length > 0 ? data.account : '' const anomID = localStorage.getItem('anomID') || (localStorage.setItem('anomID', `${navigator.userAgent}-${screen.width}x${screen.height}-${navigator.language}`.split('').reduce((hash, char) => ((hash << 5) - hash) + char.charCodeAt(0), 0).toString(36)) || localStorage.getItem('anomID')) const pendovistorID = (pendoVisitor && Object.keys(pendoVisitor).length > 0 && pendoVisitor.id) ? `${pendoVisitor.id}` : anomID; const otiService = new Oti.OtiService({ ot_key: "603e2c5b-3a1d-4eac-a9c9-fb20c3b528f2", prod_domain: "www.bioworld.com", pendo_key: "34b78be2-b210-4df9-7f2b-7552afe5341c", pendo_details: { visitor: { id: pendovistorID, firstName: pendoVisitor.first_name, lastName: pendoVisitor.last_name, email: pendoVisitor.email, country: pendoVisitor.country, company: pendoVisitor.company, last_login: pendoVisitor.last_login, opted_out_at: pendoVisitor.opted_out_at, }, account: { id: pendoAccount } }, pendo_visitor_payload: [{ visitorId: pendovistorID, values: { firstName: pendoVisitor.first_name, lastName: pendoVisitor.last_name, email: pendoVisitor.email, country: pendoVisitor.country, company: pendoVisitor.company, last_login: pendoVisitor.last_login, opted_out_at: pendoVisitor.opted_out_at, } }], pendo_visitor_url: '/ui/pendoapi/agent/value?create=true', pendo_dnp_url: `/ui/pendoapi/pendo/value/${pendovistorID}/donotprocess`, pendo_metadata_url: `/ui/pendoapi/custom/value/${pendovistorID}/bioworld_targetingcookies`, }); otiService.initialize(); }); }</script> <link rel="preload" as="script" href="https://cdn.ampproject.org/v0.js"> <script async src="https://cdn.ampproject.org/v0.js"></script>  <style amp-custom>/* Add your styles here */</style> <style amp-boilerplate>body{-webkit-animation:-amp-start 8s steps(1,end) 0s 1 normal both;-moz-animation:-amp-start 8s steps(1,end) 0s 1 normal both;-ms-animation:-amp-start 8s steps(1,end) 0s 1 normal both;animation:-amp-start 8s steps(1,end) 0s 1 normal both}@-webkit-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@-moz-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@-ms-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@-o-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}</style><noscript><style amp-boilerplate>body{-webkit-animation:none;-moz-animation:none;-ms-animation:none;animation:none}</style></noscript> <link rel="canonical" href="."> <script async custom-element="amp-iframe" src="https://cdn.ampproject.org/v0/amp-iframe-0.1.js"></script> <script>var _document$querySelect, _document$querySelect2; var $hasLogViewMeta = (_document$querySelect = document.querySelector('meta[name=has-log-view]')) === null || _document$querySelect === void 0 ? void 0 : _document$querySelect.getAttribute('content'); var $logViewUrlMeta = (_document$querySelect2 = document.querySelector('meta[name=log-view-url]')) === null || _document$querySelect2 === void 0 ? void 0 : _document$querySelect2.getAttribute('content'); if ($hasLogViewMeta === 'true') { var baseLogUrl = (typeof $logViewUrlMeta === "undefined" ? window.location.pathname : $logViewUrlMeta).replace(/(\d+)-.*$/, '$1'); var logUrl = baseLogUrl + '/log_view' + window.location.search; if (typeof navigator.sendBeacon === 'function') { navigator.sendBeacon(logUrl); } else { // Gotta love IE var request = new XMLHttpRequest(); request.open('POST', logUrl, true); request.setRequestHeader('Content-Type', 'application/x-www-form-urlencoded; charset=UTF-8'); request.send(); } }</script> </head> <body data-controller="taxonomies" data-action="show" data-prestitial-ad="false" data-poststitial-ad="false" data-news-services="BIOWORLD_SCIENCE">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5ZV86V9" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div class="document mmenu-placeholder"><header class="main-header"><div class="main-header__top"><h1> <a href="/" class="main-header__logo" data-eventaction="logo-link" data-eventcategory="click" data-eventlabel="link to homepage" data-eventname="logo-link"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 201 36" height="36" fill="none" preservAspectRatio="xMidYMid meet"> <title>BioWorld. Link to homepage.</title> <path fill="#000" d="M17.7999 16.5745v.1066c3.8891 1.5805 6.2511 4.4219 6.2511 8.3111 0 5.3809-3.9958 9.6608-11.0993 9.6608H1V1.01776h10.8506c6.9082 0 10.3712 4.27988 10.3712 8.59527 0 2.93017-1.4385 5.57627-4.4219 6.96147zM7.67732 6.68283v7.49427H11.087c2.3975 0 4.3687-1.2076 4.3687-3.8004 0-2.59283-2.06-3.69387-4.3687-3.69387H7.67732zm0 22.34057h3.46298c4.0313 0 5.9492-1.8646 5.9492-4.6173 0-2.8414-2.3619-4.2798-5.6118-4.2798H7.67732v8.8971zM35.239 34.6352h-6.2333v-16.711h-3.0723V12.632h9.3056v22.0032zM31.8293 1.01776c2.2554 0 4.0313 1.82916 4.0313 4.03125 0 2.25538-1.7759 3.97798-4.0313 3.97798-2.2021 0-3.9957-1.7226-3.9957-3.97798.0178-2.20209 1.7936-4.03125 3.9957-4.03125zM39.217 23.6425c0-6.7128 5.2389-11.5787 11.7564-11.5787 6.5175 0 11.7563 4.8481 11.7563 11.5787s-5.2388 11.5788-11.7563 11.5788c-6.5175 0-11.7564-4.8659-11.7564-11.5788zm6.2511 0c0 3.4097 2.2554 6.0025 5.523 6.0025 3.2144 0 5.4697-2.5928 5.4697-6.0025 0-3.463-2.2553-6.0025-5.4697-6.0025-3.2676 0-5.523 2.5395-5.523 6.0025zM88.7286 1.01776L95.1573 25.081h.0533l5.3814-24.06324h6.819L99.2064 34.6352h-7.7251l-6.3399-24.152-6.1979 24.152h-7.7251L62.9073 1.01776h7.2101L75.303 25.081h.0532l6.4287-24.06324h6.9437zM106.701 23.6425c0-6.7128 5.238-11.5787 11.756-11.5787 6.535 0 11.756 4.8481 11.756 11.5787s-5.239 11.5788-11.756 11.5788c-6.535-.0178-11.756-4.8659-11.756-11.5788zm6.233 0c0 3.4097 2.255 6.0025 5.523 6.0025 3.214 0 5.47-2.5928 5.47-6.0025 0-3.463-2.256-6.0025-5.47-6.0025-3.268 0-5.523 2.5395-5.523 6.0025zm34.772-4.8481h-2.646c-3.161 0-4.618 1.4917-4.618 5.3276v10.5132h-6.233V12.632h6.056v3.4985c.87-2.3441 2.983-3.8004 5.718-3.8004.586 0 1.154.0533 1.723.1954v6.2689zm9.696 15.8408h-6.198V1.01776h6.198V34.6352zm21.559-2.7881c-1.101 1.8292-3.694 3.3564-6.872 3.3564-6.056 0-10.656-4.8481-10.656-11.5787s4.564-11.5788 10.62-11.5788c3.357 0 5.914 1.545 7.015 3.4097 0-.7281-.089-2.5395-.089-4.1733V1h6.233v33.6175h-6.233v-2.7704h-.018zm-11.081-8.2046c0 3.3564 2.308 6.0558 5.612 6.0558 3.303 0 5.611-2.6994 5.611-6.0558 0-3.4097-2.308-6.0025-5.611-6.0025-3.304 0-5.612 2.5928-5.612 6.0025zM191.801 2.58054h2.06V1.01776h-5.772v1.56278h2.043V6.8249h1.669V2.58054zM201 6.8249V1.01776h-2.184l-1.119 2.84141-1.101-2.84141h-2.22V6.8249h1.652V3.13106l1.101 2.66382h1.065l1.101-2.68158v3.7116H201z"/> </svg> </a> </h1><a href='https://clarivate.com/cortellis/' target="_blank" class="main-header__logo -clarivate"> <img src="/images/Cortellis_Flagship_Logo.png" alt="Clarivate" title="Powering insights from Cortellis. Link to Cortellis page on Clarivate website."> </a></div><div class="main-nav-container"><div class="main-nav-container__wrapper"><nav id="main-nav" class="main-nav main-nav--horizontal"><div class="navigation"><ul class="main-nav-level1__items"><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld|/topics/84-bioworld" href="/topics/84-bioworld">BioWorld</a></li><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld MedTech|/topics/85-bioworld-medtech" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></li><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld Asia|/topics/86-bioworld-asia" href="/topics/86-bioworld-asia">BioWorld Asia</a></li><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld Science|/topics/520-bioworld-science" href="/topics/520-bioworld-science">BioWorld Science</a></li><li class="main-nav-level1__item"><a class="main-nav__link -has-children" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Data Snapshots|/snapshots" href="/snapshots">Data Snapshots</a><ul class="main-nav-level2__items"><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld|/snapshots" href="/snapshots">BioWorld</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld MedTech|/medtech_snapshots" href="/medtech_snapshots">BioWorld MedTech</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Infographics: Dynamic digital data analysis|/infographics-index" href="/infographics-index">Infographics: Dynamic digital data analysis</a></li></ul></li><li class="main-nav-level1__item"><a class="main-nav__link -has-children" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Special reports|/special_reports" href="/special_reports">Special reports</a><ul class="main-nav-level2__items"><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Infographics: Dynamic digital data analysis|/infographics-index" href="/infographics-index">Infographics: Dynamic digital data analysis</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Trump administration impacts|/Trump_administration_impacts" href="/Trump_administration_impacts">Trump administration impacts</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Biopharma M&A scorecard|/biopharma_MandA_scorecard" href="/biopharma_MandA_scorecard">Biopharma M&A scorecard</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld 2024 review|/BioWorld_2024_review" href="/BioWorld_2024_review">BioWorld 2024 review</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld MedTech 2024 review|https://www.bioworld.com/medtech_trends_2024" href="https://www.bioworld.com/medtech_trends_2024">BioWorld MedTech 2024 review</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld Science 2024 review|/BioWorld_Science_2024_review" href="/BioWorld_Science_2024_review">BioWorld Science 2024 review</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Women's health|/womens_health" href="/womens_health">Women's health</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="China's GLP-1 landscape|/China_GLP-1" href="/China_GLP-1">China's GLP-1 landscape</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="PFA re-energizes afib market|https://www.bioworld.com/articles/711618-pulsed-field-ablation-re-energizes-the-atrial-fibrillation-market" href="https://www.bioworld.com/articles/711618-pulsed-field-ablation-re-energizes-the-atrial-fibrillation-market">PFA re-energizes afib market</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="China CAR T|/China_CAR_T" href="/China_CAR_T">China CAR T</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Alzheimer's disease|/Alzheimers" href="/Alzheimers">Alzheimer's disease</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Israel|/israel" href="/israel">Israel</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Rise of obesity|/rise_of_obesity" href="/rise_of_obesity">Rise of obesity</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Radiopharmaceuticals|/radiopharmaceuticals" href="/radiopharmaceuticals">Radiopharmaceuticals</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Biosimilars|/biosimilars" href="/biosimilars">Biosimilars</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Aging|/aging" href="/aging">Aging</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="IVDs on the rise|/IVDs-2021" href="/IVDs-2021">IVDs on the rise</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Coronavirus|/articles/topic/517" href="/articles/topic/517">Coronavirus</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Artificial intelligence|/AI_series" href="/AI_series">Artificial intelligence</a></li></ul></li></ul></div></nav><div class="main-nav-container__mobile-nav"><a class="hamburger-nav-link" href="#" id="hamburger-nav-link"></a><h1> <a href="/" class="main-header__logo" data-eventaction="logo-link" data-eventcategory="click" data-eventlabel="link to homepage" data-eventname="logo-link"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 201 36" height="36" fill="none" preservAspectRatio="xMidYMid meet"> <title>BioWorld. Link to homepage.</title> <path fill="#000" d="M17.7999 16.5745v.1066c3.8891 1.5805 6.2511 4.4219 6.2511 8.3111 0 5.3809-3.9958 9.6608-11.0993 9.6608H1V1.01776h10.8506c6.9082 0 10.3712 4.27988 10.3712 8.59527 0 2.93017-1.4385 5.57627-4.4219 6.96147zM7.67732 6.68283v7.49427H11.087c2.3975 0 4.3687-1.2076 4.3687-3.8004 0-2.59283-2.06-3.69387-4.3687-3.69387H7.67732zm0 22.34057h3.46298c4.0313 0 5.9492-1.8646 5.9492-4.6173 0-2.8414-2.3619-4.2798-5.6118-4.2798H7.67732v8.8971zM35.239 34.6352h-6.2333v-16.711h-3.0723V12.632h9.3056v22.0032zM31.8293 1.01776c2.2554 0 4.0313 1.82916 4.0313 4.03125 0 2.25538-1.7759 3.97798-4.0313 3.97798-2.2021 0-3.9957-1.7226-3.9957-3.97798.0178-2.20209 1.7936-4.03125 3.9957-4.03125zM39.217 23.6425c0-6.7128 5.2389-11.5787 11.7564-11.5787 6.5175 0 11.7563 4.8481 11.7563 11.5787s-5.2388 11.5788-11.7563 11.5788c-6.5175 0-11.7564-4.8659-11.7564-11.5788zm6.2511 0c0 3.4097 2.2554 6.0025 5.523 6.0025 3.2144 0 5.4697-2.5928 5.4697-6.0025 0-3.463-2.2553-6.0025-5.4697-6.0025-3.2676 0-5.523 2.5395-5.523 6.0025zM88.7286 1.01776L95.1573 25.081h.0533l5.3814-24.06324h6.819L99.2064 34.6352h-7.7251l-6.3399-24.152-6.1979 24.152h-7.7251L62.9073 1.01776h7.2101L75.303 25.081h.0532l6.4287-24.06324h6.9437zM106.701 23.6425c0-6.7128 5.238-11.5787 11.756-11.5787 6.535 0 11.756 4.8481 11.756 11.5787s-5.239 11.5788-11.756 11.5788c-6.535-.0178-11.756-4.8659-11.756-11.5788zm6.233 0c0 3.4097 2.255 6.0025 5.523 6.0025 3.214 0 5.47-2.5928 5.47-6.0025 0-3.463-2.256-6.0025-5.47-6.0025-3.268 0-5.523 2.5395-5.523 6.0025zm34.772-4.8481h-2.646c-3.161 0-4.618 1.4917-4.618 5.3276v10.5132h-6.233V12.632h6.056v3.4985c.87-2.3441 2.983-3.8004 5.718-3.8004.586 0 1.154.0533 1.723.1954v6.2689zm9.696 15.8408h-6.198V1.01776h6.198V34.6352zm21.559-2.7881c-1.101 1.8292-3.694 3.3564-6.872 3.3564-6.056 0-10.656-4.8481-10.656-11.5787s4.564-11.5788 10.62-11.5788c3.357 0 5.914 1.545 7.015 3.4097 0-.7281-.089-2.5395-.089-4.1733V1h6.233v33.6175h-6.233v-2.7704h-.018zm-11.081-8.2046c0 3.3564 2.308 6.0558 5.612 6.0558 3.303 0 5.611-2.6994 5.611-6.0558 0-3.4097-2.308-6.0025-5.611-6.0025-3.304 0-5.612 2.5928-5.612 6.0025zM191.801 2.58054h2.06V1.01776h-5.772v1.56278h2.043V6.8249h1.669V2.58054zM201 6.8249V1.01776h-2.184l-1.119 2.84141-1.101-2.84141h-2.22V6.8249h1.652V3.13106l1.101 2.66382h1.065l1.101-2.68158v3.7116H201z"/> </svg> </a> </h1><a class="search-nav-link" href="#" id="search-nav-link"></a><form action="/search" class="mobile-search" id="mobile-search" method="get"><input class="mobile-search__field" name="q" placeholder="What are you looking for?" type="text" /><button class="mobile-search__icon" type="submit"></button></form></div><div class="main-nav-container__nav2"><nav class="user-actions" id="user-actions"> <ul class="user-actions__list"> <li class="user-actions__signin"> <a class="user-actions__signin-link" href="/user/login">Sign In</a> </li> <li class="user-actions__signout"> <a class="user-actions__signout-link" href="/user/logout">Sign Out</a> </li> <li class="user-actions__account"> <a class="user-actions__account-link" href="/user/profile">My Account</a> </li> </ul> </nav> <a class="main-nav-container__subscribe-link" href="/subscriptions">Subscribe</a><div class="quick-search" id="quick-search"><form action="/search" id="quick-search-form" method="GET" name="quick-search" target="_top"><div class="quick-search__wrapper" role="presentation"><input class="quick-search__search-field" id="q" name="q" placeholder="Search" type="text" /><button class="quick-search__button" title="Search" type="submit"></button></div></form></div></div></div></div></header><div class="container container-full"><section class="site-banner" id="site-banner"><div class="site-banner__date">BioWorld - Monday, February 17, 2025</div><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_SCIENCE" target="_blank" href="https://clarivate.com/news/bioworld-by-clarivate-releases-comprehensive-2024-year-in-review/">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/717493-five-med-tech-trends-to-watch-in-2025">Breaking News: Five med-tech trends to watch in 2025</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a></section><section class="featured-stories__wrapper -primary-4 --secondary-4"><div class="featured-stories__primary "><section class="featured-stories "> <div class="featured-stories__items-wrapper"><ul class="featured-stories__items featured-stories__items-1"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><figure class="featured-stories__image"><a class="featured-stories__thumbnail-link" data-eventname="featured-stories" data-eventcategory="click" data-eventaction="featured-stories-image" data-eventlabel="https://www.bioworld.com/articles/717284-insights-into-extracellular-matrix-are-metastasis-map" href="https://www.bioworld.com/articles/717284-insights-into-extracellular-matrix-are-metastasis-map"><img class="featured-stories__image-thumb" alt="Cancer cells under magnifying glass" title="Cancer cells under magnifying glass" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-cell-under-magnifying-glass.png?height=355&t=1611092780&width=640" /></a></figure><div class="featured-stories__details featured-stories__details-1"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717284-insights-into-extracellular-matrix-are-metastasis-map">Insights into extracellular matrix are metastasis map</a></h1><div class="featured-stories__teaser">New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ from ECM. The findings will make it easier to identify tumors that are likely to metastasize at an early stage.</div></div></article> </li> </ul><ul class="featured-stories__items featured-stories__items-2"> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717285-apd-94-a-dual-functional-inhibitor-of-bmi-1-and-tubulin">APD-94, a dual functional inhibitor of Bmi-1 and tubulin</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717286-ensomas-en-374-designated-orphan-drug-for-x-linked-chronic-granulomatous-disease">Ensoma’s EN-374 designated orphan drug for X-linked chronic granulomatous disease</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases">Seed funding at Junevity supports siRNA therapeutics for age-related diseases</a></h1></article> </li> </ul></div> </section></div><div class="featured-stories__secondary"><section class="featured-stories "> <ul class="featured-stories__items"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717284-insights-into-extracellular-matrix-are-metastasis-map">Insights into extracellular matrix are metastasis map</a></h1><div class="featured-stories__teaser">New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ from ECM. The findings will make it easier to identify tumors that are likely to metastasize at an early stage.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717285-apd-94-a-dual-functional-inhibitor-of-bmi-1-and-tubulin">APD-94, a dual functional inhibitor of Bmi-1 and tubulin</a></h1><div class="featured-stories__teaser">Researchers from Hebei Normal University and affiliated organizations presented the discovery and preclinical characterization of a novel B lymphoma Mo-MLV insertion region 1 (Bmi-1) expression inhibitor, APD-94, designed as an agent that could potentially overcome drug resistance in patients with colorectal cancer.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717286-ensomas-en-374-designated-orphan-drug-for-x-linked-chronic-granulomatous-disease">Ensoma’s EN-374 designated orphan drug for X-linked chronic granulomatous disease</a></h1><div class="featured-stories__teaser">Ensoma Inc.’s lead program, EN-374, has been granted orphan drug and rare pediatric disease designations by the FDA for the treatment of X-linked chronic granulomatous disease. Ensoma anticipates filing an IND application for EN-374 in the first half of this year.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases">Seed funding at Junevity supports siRNA therapeutics for age-related diseases</a></h1><div class="featured-stories__teaser">Junevity Inc. has raised $10 million in seed funding to support its work creating silencing RNA (siRNA) therapeutics to address metabolic and age-related diseases, including type 2 diabetes, obesity and frailty. The seed funding will be used to enhance the company’s RESET platform and develop its first therapeutic candidates in these indications.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/712279-other-news-to-note-for-feb-14-2025">Other news to note for Feb. 14, 2025</a></h1><div class="featured-stories__teaser">Additional early-stage research and drug discovery news in brief.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717296-apogee-pharmaceuticals-discloses-new-faah-inhibitors">Apogee Pharmaceuticals discloses new FAAH inhibitors</a></h1><div class="featured-stories__teaser">Apogee Pharmaceuticals Inc. has prepared fatty acid amide hydrolase (FAAH) inhibitors reported to be useful for the treatment of cancer, pain, inflammation, anxiety and mood disorders, cardiovascular disorders, autoimmune diseases and neurological disorders, among others.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717288-akesos-il-4r-st2-bispecific-antibody-gains-ind-clearance-in-china">Akeso’s IL-4Rα/ST2 bispecific antibody gains IND clearance in China</a></h1><div class="featured-stories__teaser">Akeso Inc. has received IND approval by China’s National Medical Products Administration (NMPA) for AK-139, an IL-4Rα/ST2 bispecific antibody under investigation for a number of indications, including respiratory and skin diseases.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717289-new-immunocompetent-syngeneic-dvl3-mouse-model-of-prostate-cancer">New immunocompetent syngeneic DVL3 mouse model of prostate cancer</a></h1><div class="featured-stories__teaser">Previous research has shown that aberrant sphingolipid metabolism, which is evidenced by elevated levels of circulating ceramide, is associated with poor prognosis in patients with prostate cancer (PC). Work at the University of Adelaide has led to the establishment of a new syngeneic mouse model to study the role of sphingolipid metabolism in PC.</div></article> </li> </ul> </section></div><div class="news-service articles-by-site-placement-tax"><section class="featured-stories-by-site-placement__wrapper"><section class="featured-stories-by-site-placement "> <div class="featured-stories-by-site-placement__items-wrapper"><ul class="featured-stories-by-site-placement__items featured-stories-by-site-placement__items-1"> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders">Mair Therapeutics launches with focus on neurodegenerative disorders</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders" href="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders"><img class="featured-stories-by-site-placement__image-thumb" alt="Brain as light bulb filament" title="Brain as light bulb filament" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Brain-as-filament-in-light-bulb.jpg?height=146&t=1695308372&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717297-usp1-inhibitors-detailed-in-laekna-therapeutics-patents">USP1 inhibitors detailed in Laekna Therapeutics patents</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717298-roche-patents-new-sik-inhibitors">Roche patents new SIK inhibitors </a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia">RNA panel detects and differentiates prostate cancer from benign prostate hyperplasia</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia" href="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia"><img class="featured-stories-by-site-placement__image-thumb" alt="3D illustration showing presence of tumor inside prostate gland " title="3D illustration showing presence of tumor inside prostate gland " width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-prostate-illustration.jpg?height=146&t=1721842077&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717299-neumora-therapeutics-reports-nmda-receptor-positive-allosteric-modulators">Neumora Therapeutics reports NMDA receptor positive allosteric modulators</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717300-bsense-bio-therapeutics-identifies-new-kcnq2-3-and-trpv1-modulators">Bsense Bio Therapeutics identifies new KCNQ2/3 and TRPV1 modulators</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717292-boronic-acid-inhibitors-restore-cefepime-efficacy-in-multidrug-resistant-kpc-producing-emk-pneumoniae-em">Boronic acid inhibitors restore cefepime efficacy in multidrug-resistant KPC-producing <em>K. pneumoniae</em></a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/717292-boronic-acid-inhibitors-restore-cefepime-efficacy-in-multidrug-resistant-kpc-producing-emk-pneumoniae-em" href="https://www.bioworld.com/articles/717292-boronic-acid-inhibitors-restore-cefepime-efficacy-in-multidrug-resistant-kpc-producing-emk-pneumoniae-em"><img class="featured-stories-by-site-placement__image-thumb" alt="Klebsiella pneumoniae colonies in petri dish" title="Klebsiella pneumoniae colonies in petri dish" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Klebsiella-pneumoniae-colonies-petri-dish.jpg?height=146&t=1739551421&width=193" /></a></figure></div></article> </li> </ul></div> </section></section></div></section><div class="topic-podcast"><div class="adplugg-tag" data-adplugg-zone="bioworld_science_banner"></div><section class="bioworld-podcasts-component"><div class="bioworld-podcasts-component__wrapper"><div class="bioworld-podcasts-component__content"><h3 class="bioworld-podcasts-component__headline"><a class="bioworld-podcasts-component__headline-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast">BioWorld Insider Podcast</a></h3><div class="bioworld-podcasts-component__body"><img src="https://www.bioworld.com/ext/resources/Podcast-files/play-circle-button.png?1718131949" style="display: inline-block; vertical-align: bottom; margin: 5px 0px 5px 5px; text-align: right; float: right; max-width: calc(100% - 5px); width: 95px;" alt="Play button" data-uuid="YTAtMTE1OTM1" align="right">The <em>BioWorld Insider</em> podcast is a monthly dive into the business and science of drug development. Conversations with CEOs and <em>BioWorld</em> analysts in the past 12 months have included a wide range of chats with experts who are shaping the future.</div><a class="bioworld-podcasts-component__link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast">Listen now</a><div class="bioworld-podcasts-component__adplugg-ad"><div class="adplugg-tag" data-adplugg-zone="bioworld_podcasts_science"></div></div></div></div></section></div><section class="topics-section__wrapper"><div class="topics-section__primary"><section class="topics-section "> <h1 class="topics-section__title"><a class="topics-section__title-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-title" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">Conferences</a></h1><ul class="topics-section__items"> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717228-microglial-igsf6-knockdown-reduces-ischemic-brain-injury-post-stroke">Microglial IGSF6 knockdown reduces ischemic brain injury post-stroke</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/250,520">Immune</a></div><div class="topics-section__teaser">Researchers in from Nanjing Drum Tower Hospital have presented data from a study that investigated the role of immunoglobulin superfamily member 6 (IGSF6) microglia during ischemic stroke.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/717226-ca-1001-shows-potent-anti-thrombotic-effects-in-stroke" href="https://www.bioworld.com/articles/717226-ca-1001-shows-potent-anti-thrombotic-effects-in-stroke"><img class="topics-section__image-thumb" alt="Bloodstream with red and white blood cells and platelets" title="Bloodstream with red and white blood cells and platelets" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Hematologic/Bloodstream-illustration.jpg?height=355&t=1692650628&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717226-ca-1001-shows-potent-anti-thrombotic-effects-in-stroke">CA-1001 shows potent anti-thrombotic effects in stroke</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/240,520">Cardiovascular</a></div><div class="topics-section__teaser">CCOA Therapeutics Inc. has presented data on their anti-platelet glycoprotein Ibα (GPIbα) humanized antibody fragment CA-1001.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717191-lilrb4-relieves-brain-damage-through-decreased-microglial-necroptosis">LILRB4 relieves brain damage through decreased microglial necroptosis</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/240,520">Cardiovascular</a></div><div class="topics-section__teaser">Microglia play a crucial role in neuroinflammation after ischemic brain injury. Previous data have shown that leukocyte immunoglobulin-like receptor B4 (LILRB4) was upregulated in mice after middle cerebral artery occlusion (MCAO), but the role it plays here is not well understood. The role LILRB4...</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/717189-pali-2108-colon-activated-prodrug-prevents-ulcerative-colitis-progression" href="https://www.bioworld.com/articles/717189-pali-2108-colon-activated-prodrug-prevents-ulcerative-colitis-progression"><img class="topics-section__image-thumb" alt="Gastrointestinal system with ulcerative colitis." title="Gastrointestinal system with ulcerative colitis." width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/IBD-ulcerative-colitis.png?height=355&t=1668182386&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717189-pali-2108-colon-activated-prodrug-prevents-ulcerative-colitis-progression">PALI-2108 colon-activated prodrug prevents ulcerative colitis progression</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/247,520">Gastrointestinal</a></div><div class="topics-section__teaser">Ulcerative colitis is a chronic, immune-mediated disorder of the colon and rectum characterized by mucosal inflammation that damages the bowel wall surface. Current therapeutic options include 5-aminosalicylates, corticosteroids or anti-TNF agents, but there is a need for new strategies to obtain...</div></div></article> </li> </ul><a class="topics-section__more-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-more-link" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">More in Conferences</a> </section></div><div class="topics-section__aside"><section class="news-in-brief "> <h1 class="news-in-brief__title">Today's news in brief</h1><ul class="news-in-brief__items"> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/717301-other-news-to-note-for-feb-14-2025">Other news to note for Feb. 14, 2025</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689316-respiratory">Respiratory</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689317-dermatologic">Dermatologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689318-cardiovascular">Cardiovascular</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689319-hematologic">Hematologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689320-nephrology">Nephrology</a></h1></article> </li> </ul> </section></div></section><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/472-patents" href="/articles/topic/472-patents">Patents</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717255-university-of-minnesota-discovers-senolytic-compounds">University of Minnesota discovers senolytic compounds </a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717254-horizon-therapeutics-synthesizes-new-igf-1r-inhibitors-for-graves-ophthalmopathy">Horizon Therapeutics synthesizes new IGF-1R inhibitors for Graves’ ophthalmopathy</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717253-il-13ra2-adcs-disclosed-in-exelixis-patent">IL-13RA2 ADCs disclosed in Exelixis patent</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717252-brii-biosciences-patents-new-th-agonist-prodrugs-for-multiple-sclerosis">Brii Biosciences patents new TH-β agonist prodrugs for multiple sclerosis</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717251-merck-sharp-and-dohme-prepares-new-kras-g12d-degrader-protacs">Merck Sharp & Dohme prepares new KRAS G12D degrader PROTACs</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717237-tb-alliance-discovers-new-clpp1p2-protease-inhibitors-for-tuberculosis">TB Alliance discovers new ClpP1P2 protease inhibitors for tuberculosis</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717236-fgfr2-3-inhibitors-reported-in-genescience-pharmaceuticals-patent">FGFR2/3 inhibitors reported in Genescience Pharmaceuticals patent</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717235-bristol-myers-squibb-discloses-new-pad4-inhibitors-for-rheumatoid-arthritis">Bristol Myers Squibb discloses new PAD4 inhibitors for rheumatoid arthritis</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717234-university-of-florida-patent-describes-rev-erba-antagonists">University of Florida patent describes Rev-erbA-α antagonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717233-lilly-patents-compounds-with-lpa-lowering-activity">Lilly patents compounds with Lp(a)-lowering activity</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">Cancer</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/717245-ksp-targeting-protac-with-potent-antitumor-efficacy" href="https://www.bioworld.com/articles/717245-ksp-targeting-protac-with-potent-antitumor-efficacy"><img class="bioworld-biome__image-thumb" alt="Art concept for tumor" title="Art concept for tumor" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-tumor-blood-supply-vessels.jpg?height=355&t=1683905894&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717245-ksp-targeting-protac-with-potent-antitumor-efficacy">KSP-targeting PROTAC with potent antitumor efficacy</a></h1><div class="bioworld-biome__teaser">Researchers from Wuyi University presented the discovery and preclinical characterization of kinesin spindle protein (KSP) degraders developed using proteolysis-targeting chimera (PROTAC) technology.</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717242-xilio-advances-masked-t-cell-engagers-targeting-psma-cldn182-and-steap1">Xilio advances masked T-cell engagers targeting PSMA, CLDN18.2 and STEAP1</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/217,520">Collaboration</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717240-nanrilkefusp-alfa-stimulates-nk-and-cd8-t-cells-in-the-tumor-microenvironment">Nanrilkefusp alfa stimulates NK and CD8+ T cells in the tumor microenvironment</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/280,520">Immuno-oncology</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717232-broad-ceacam6-targeted-strategy-for-solid-tumors">Broad CEACAM6-targeted strategy for solid tumors</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/269,520">Antibody-drug conjugate</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717231-chimeric-nanoparticles-tested-in-t-cell-lymphomas-gastric-cancer">Chimeric nanoparticles tested in T-cell lymphomas, gastric cancer</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/280,520">Immuno-oncology</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">More in Cancer</a> </section></div><div class="adplugg-tag" data-adplugg-zone="bioworld_science_promo_1"></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">Infection</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/717241-gates-foundation-novo-nordisk-foundation-and-wellcome-set-sights-on-antimicrobial-resistance" href="https://www.bioworld.com/articles/717241-gates-foundation-novo-nordisk-foundation-and-wellcome-set-sights-on-antimicrobial-resistance"><img class="clinical__image-thumb" alt="Bacterial colonies in petri dishes" title="Bacterial colonies in petri dishes" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Bacterial-colonies-in-petri-dishes.png?height=355&t=1646348605&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717241-gates-foundation-novo-nordisk-foundation-and-wellcome-set-sights-on-antimicrobial-resistance">Gates Foundation, Novo Nordisk Foundation and Wellcome set sights on antimicrobial resistance</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/117,520">Drug resistance</a></div><div class="clinical__teaser">The Gates Foundation, Novo Nordisk Foundation and Wellcome have announced the launch of the Gram-Negative Antibiotic Discovery Innovator (Gr-ADI), a $50 million investment that will focus on combatting antimicrobial resistance (AMR) caused by a specific range of bacteria that are among the leading...</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717239-emplasmodium-em-essential-gene-map-gives-malaria-pharmacologic-clues"><em>Plasmodium</em> essential gene map gives malaria pharmacologic clues</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/249,520">Hematologic</a></div><div class="clinical__teaser">Two simultaneous but independent studies published in <em>Science</em> identified, by introducing mutants into its genome, the essential and nonessential genes of <em>Plasmodium knowlesi</em>, one of the malaria parasites related to the dreaded <em>Plasmodium vivax</em>. Their results could help in the development and...</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717230-bioversys-identifies-optimized-lead-compounds-in-bv500-ntm-program">Bioversys identifies optimized lead compounds in BV500 NTM program</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/263,520">Respiratory</a></div><div class="clinical__teaser">Bioversys AG has announced that its BV500 NTM program has reached its second milestone with the identification of up to five optimized lead compounds, under the CF AMR Syndicate collaborative discovery program agreement.</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717190-organogold-compound-disrupts-emleishmania-em-mitochondria-and-delays-lesion-progression-in-vivo">Organogold compound disrupts <em>Leishmania</em> mitochondria and delays lesion progression in vivo</a></h1></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717132-cspcs-herpes-zoster-vaccine-gains-clinical-trial-clearance-in-china">CSPC’s herpes zoster vaccine gains clinical trial clearance in China</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/402,520">Regulatory</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717057-new-multi-epitope-hiv-1-vaccine-based-on-virus-like-particles-engineered-to-enhance-immune-response">New multi-epitope HIV-1 vaccine based on virus-like particles engineered to enhance immune response</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/542,520">HIV/AIDS</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717044-merck-sharp-and-dohme-describes-new-gag-polyprotein-hiv-1-protein-pol-dimerization-inducers">Merck Sharp & Dohme describes new Gag polyprotein (HIV-1)/protein Pol dimerization inducers</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/542,520">HIV/AIDS</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">More in Infection</a> </section></div></div></section><div class="deals-m-a__wrapper"><section class="deals-m-a "> <h1 class="deals-m-a__title"><a class="deals-m-a__title-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-title" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">Neurology/psychiatric</a></h1><ul class="deals-m-a__items"> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/717244-fkbp5-inhibition-protects-from-neurodegeneration-in-parkinsons-disease-models" href="https://www.bioworld.com/articles/717244-fkbp5-inhibition-protects-from-neurodegeneration-in-parkinsons-disease-models"><img class="deals-m-a__image-thumb" alt="Brain and neural networks" title="Brain and neural networks" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Neurodegenerative-disease.png?height=355&t=1623075193&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717244-fkbp5-inhibition-protects-from-neurodegeneration-in-parkinsons-disease-models">FKBP5 inhibition protects from neurodegeneration in Parkinson’s disease models</a></h1><div class="deals-m-a__teaser">Loss of dopaminergic neurons in the substantia nigra and accumulation of α-synuclein (α-Syn) aggregates are the major hallmarks of Parkinson’s disease (PD).</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717225-voyager-to-evaluate-alternate-payloads-for-als-gene-therapy-program">Voyager to evaluate alternate payloads for ALS gene therapy program</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/278,520">Gene therapy</a></div><div class="deals-m-a__teaser">Voyager Therapeutics Inc. has announced its decision to assess alternate payloads related to its gene therapy program for superoxide dismutase 1 (SOD1) amyotrophic lateral sclerosis (ALS). Emerging preclinical data indicate the siRNA payload component of VY-9323 does not meet its standards due to...</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717188-gl-ii-73-demonstrates-procognitive-and-neurotrophic-effects-in-amyloid-deposition-mouse-model">GL-II-73 demonstrates procognitive and neurotrophic effects in β-amyloid deposition mouse model</a></h1><div class="deals-m-a__teaser">Researchers from the Centre for Addiction and Mental Health (CAMH) and affiliated organizations presented preclinical data for the α5-GABA-A receptor (α5-GABAAR) positive allosteric modulator GL-II-73 (DPX-101), which is being developed by Damona Pharmaceuticals Inc. for the treatment of...</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717149-us-uk-team-reports-compounds-for-diagnosis-and-treatment-of-neurodegenerative-disorders">US, UK team reports compounds for diagnosis and treatment of neurodegenerative disorders</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">The Brigham and Women's Hospital Inc., Massachusetts General Hospital and UCL Business Ltd. have jointly patented new benzo[<em>c</em>][l,2,5]thiadiazolyl compounds and radiolabeled derivatives targeting α-synuclein, amyloid-β (Aβ) protein and microtubule-associated protein tau.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717060-s1p1-receptor-agonist-protects-brain-from-small-vessel-disease">S1P1 receptor agonist protects brain from small vessel disease</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="deals-m-a__teaser">Early dysfunction of the endothelial/blood-brain barrier (BBB) is involved in the pathogenesis of cerebral small vessel disease (SVD), which is a contributor to about 50% of dementias. Sphingosine-1-phosphate (S1P) is a sphingolipid that regulates the BBB integrity when bound to its receptor S1P1...</div></div></article> </li> </ul><a class="deals-m-a__more-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-more-link" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">More in Neurology/psychiatric</a> </section></div><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/250-immune" href="/articles/topic/250-immune">Immune</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717243-lycia-therapeutics-advances-protein-degradation-therapies">Lycia Therapeutics advances protein degradation therapies</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717120-rbm47-a-new-target-to-watch-in-thyroid-associated-ophthalmopathy">RBM47, a new target to watch in thyroid-associated ophthalmopathy</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717035-grifols-collaborates-with-fcr-therapeutics-on-autoimmune-diseases">Grifols collaborates with FcR Therapeutics on autoimmune diseases</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716853-kat6a-inhibition-as-new-therapeutic-strategy-for-ige-mediated-allergic-diseases">KAT6A inhibition as new therapeutic strategy for IgE-mediated allergic diseases</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716852-lactigas-secretory-iga-replacement-therapy-for-compromised-immune-function-receives-niaid-funding">Lactiga’s secretory IgA replacement therapy for compromised immune function receives NIAID funding</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716761-antibody-prevents-severe-bird-flu-in-macaques">Antibody prevents severe bird flu in macaques </a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716748-updated-rna-vaccine-protects-mice-against-emerging-h5n1-strain">Updated RNA vaccine protects mice against emerging H5N1 strain</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716698-allogenes-allo-329-gains-ind-clearance-for-autoimmune-diseases">Allogene’s ALLO-329 gains IND clearance for autoimmune diseases</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716694-the-brain-ages-and-survives-differently-in-females-and-males">The brain ages and survives differently in females and males</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716645-ocugens-ocu-500-inhaled-mucosal-vaccine-for-covid-19-gains-ind-clearance">Ocugen’s OCU-500 inhaled mucosal vaccine for COVID-19 gains IND clearance</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">Endocrine/metabolic</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717247-scaav9-sumf1-shows-safety-and-efficacy-as-gene-replacement-therapy-for-the-treatment-of-multiple-sulfatase-deficiency">scAAV9/SUMF1 shows safety and efficacy as gene replacement therapy for the treatment of multiple sulfatase deficiency</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/278,520">Gene therapy</a></div><div class="bioworld-biome__teaser">Multiple sulfatase deficiency is an autosomal recessive lysosomal storage disorder caused by homozygous or compound heterozygous loss-of-function mutations in the <em>SUMF1</em> gene, which encodes formylglycine generating enzyme (FGE), which catalyzes the post-translational modification of all known 17...</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717221-adrenomedullin-pathway-leads-to-insulin-resistance-in-obesity">Adrenomedullin pathway leads to insulin resistance in obesity </a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/240,520">Cardiovascular</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717116-new-prophylactic-immunomodulation-for-upcoming-4d-310-trials-presented">New prophylactic immunomodulation for upcoming 4D-310 trials presented</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717036-arbors-abo-101-awarded-us-orphan-drug-designation-for-primary-hyperoxaluria-type-1">Arbor’s ABO-101 awarded US orphan drug designation for primary hyperoxaluria type 1</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/402,520">Regulatory</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717032-entos-awarded-cirm-grant-to-advance-entlep-001-for-congenital-generalized-lipodystrophy">Entos awarded CIRM grant to advance ENTLEP-001 for congenital generalized lipodystrophy</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/223,520">Grant</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">More in Endocrine/metabolic</a> </section></div><div class="adplugg-tag" data-adplugg-zone="bioworld_science_promo_2"></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">Biomarkers</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/717192-cdca4-as-new-molecular-target-for-bladder-cancer" href="https://www.bioworld.com/articles/717192-cdca4-as-new-molecular-target-for-bladder-cancer"><img class="clinical__image-thumb" alt="Bladder cancer illustration" title="Bladder cancer illustration" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Bladder-cancer.png?height=355&t=1588882820&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717192-cdca4-as-new-molecular-target-for-bladder-cancer">CDCA4 as new molecular target for bladder cancer</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="clinical__teaser">Previous research has shown that cell division cycle associated 4 (CDCA4) is overexpressed in multiple tumors and is involved in tumor progression. Researchers from Yangtze University and affiliated organizations investigated the role of CDCA4 in bladder cancer.</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716615-ep400-variants-linked-to-epilepsy-neurodevelopmental-disorders">EP400 variants linked to epilepsy, neurodevelopmental disorders</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/256,520">Neurology/psychiatric</a></div><div class="clinical__teaser">Researchers from Guangzhou Medical University and affiliated organizations presented data from a study that aimed to investigate the disease-causing mechanism of EP400, a gene that encodes the E1A binding protein p400, which is a core catalytic ATPase subunit of ATP-dependent chromatin remodeling...</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716568-dap3-gene-behind-perrault-syndrome-study-finds">DAP3 gene behind Perrault syndrome, study finds</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/548,520">Genetic/congenital</a></div><div class="clinical__teaser">Mitoribosomes are present in the mitochondria of all eukaryotic cells. Their function is to allow the translation of mitochondrial mRNA that exclusively encodes components of the oxidative phosphorylation complexes (OXPHOS). </div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716491-wnt-pcp-signaling-mediators-identified-as-new-markers-in-yellow-nail-syndrome">Wnt/PCP signaling mediators identified as new markers in yellow nail syndrome</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/242,520">Dermatologic</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716320-new-findings-tie-tlx3-to-autism-spectrum-disorder">New findings tie TLX3 to autism spectrum disorder</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/256,520">Neurology/psychiatric</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/715806-rare-btnl8-variants-associated-with-altered-intestinal-permeability-are-enriched-in-mis-c-patients">Rare BTNL8 variants associated with altered intestinal permeability are enriched in MIS-C patients</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/250,520">Immune</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/715743-circulating-splicing-factor-srrm1-a-potential-biomarker-and-therapeutic-target-in-prostate-cancer">Circulating splicing factor SRRM1: a potential biomarker and therapeutic target in prostate cancer </a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/239,520">Cancer</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">More in Biomarkers</a> </section></div></div></section><section class="topics-section-3__wrapper"><div class="topics-section-3__col"><section class="regulatory "> <h1 class="regulatory__title"><a class="regulatory__title-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-title" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">Gastrointestinal</a></h1><ul class="regulatory__items"> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717223-hmga1-modulates-wnt-driven-tumorigenesis-in-colorectal-cancer">HMGA1 modulates Wnt-driven tumorigenesis in colorectal cancer</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="regulatory__teaser">A recent study published in the <em>Journal of Clinical Investigation</em> by researchers at Johns Hopkins University School of Medicine and collaborators identified HMGA1 as a key epigenetic regulator that enhances Wnt signaling in colon cancer.</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717187-anti-dr3-antibody-demonstrates-efficacy-in-the-treatment-of-ibd">Anti-DR3 antibody demonstrates efficacy in the treatment of IBD</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="regulatory__teaser">Death receptor 3 (DR3) is the only signaling receptor for TNF superfamily ligand TL1A, the dysregulation of which has been implicated in multiple inflammatory diseases such as inflammatory bowel disease (IBD). Blockade of TL1A has been shown to...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717015-study-hints-at-new-target-for-acute-pancreatitis">Study HINTs at new target for acute pancreatitis</a></h1><div class="regulatory__teaser">Acute pancreatitis (AP) is a gastrointestinal disorder characterized by inflammation and necrosis of the pancreatic acinar cells. Mitochondrial homeostasis is key to energy metabolism and redox homeostasis, both of which are essential for...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/716766-mr-2938-regulates-gut-microbiota-composition-and-alleviates-dss-induced-colitis">MR-2938 regulates gut microbiota composition and alleviates DSS-induced colitis</a></h1><div class="regulatory__teaser">Researchers from Ocean University of China and Qingdao Marine Science and Technology Center published data from a preclinical study that investigated the impact of the quinazolinone derivative MR-2938 on gut microbiota during colitis. A dextran...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/716743-combined-strategy-can-prevent-pancreatic-cancer-drug-resistance">Combined strategy can prevent pancreatic cancer drug resistance</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/117,520">Drug resistance</a></div><div class="regulatory__teaser">Understanding the mechanisms of resistance to cancer treatments is necessary to find effective therapies at different stages of the disease. Scientists at UT Southwestern Medical Center studied the most frequent mutation in pancreatic ductal...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/716716-tlr4-behind-severity-of-ileitis-and-enteric-neuropathy">TLR4 behind severity of ileitis and enteric neuropathy</a></h1><div class="regulatory__teaser">It was hypothesized that the crosstalk between Toll-like receptors, especially Toll-like receptor 4 (TLR4), and serotonergic machinery during inflammation may be an important factor for understanding the neuroimmune mechanisms participating in...</div></article> </li> </ul><a class="regulatory__more-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-more-link" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">More in Gastrointestinal</a> </section></div><div class="topics-section-3__col"><h2><a class="topics-section__title-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast"><strong>BioWorld Insider Podcast</strong></a></h2> <p> <strong>One-on-one with medical innovators</strong> </p> <table style="width: 100%;"><tbody><tr><td style="width: 100.0000%;"> <p class="regulatory__teaser"> <img src="/ext/resources/images/podcast-section-image.png" style="display: inline-block; vertical-align: bottom; margin: 2px 15px 5px 0px; text-align: left; float: left; max-width: calc(100% - 5px); width: 221px;" alt="podcast microphone, sound waves on purple background" data-uuid="YTAtMTA2MzQz" align="left">Breakthrough medicines, billion-dollar deals, spectacular clinical successes and crushing failures all play a part in biopharma’s dynamic story. Developers make scientific advancements with the potential to change everything, only to face regulatory conundrums and ever-fluctuating markets. BioWorld tracks key events in the fast-moving sector every business day. Now, the BioWorld Insider podcast lets you hear directly from the movers and shakers whose collective work is changing how we all live. Join us each week for a new conversation. </p> </td></tr> <tr><td style="width: 100.0000%;"> <p class="regulatory__teaser"> <br><strong>Recent episodes:</strong> </p> <ul class="regulatory__teaser"> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/53-healing-the-health-divide-for-women" rel=" " target="_self">Healing the health divide for women</a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/52-modifi-gets-creative-on-the-rocky-road-to-a-multibillion-dollar-buyout" rel=" " target="_self">Modifi gets creative on the rocky road to a multibillion-dollar buyout</a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/51-a-quantum-leap-into-the-future-of-drug-development" rel=" noopener noreferrer">A quantum leap into the future of drug development<br></a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/50-gene-and-cell-therapies-will-propel-innovation-says-astellas-cco" rel=" noopener noreferrer" target="_self">Gene and cell therapies will propel innovation, says Astellas CCO<br></a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/49-capricor-s-ceo-pursues-a-bla-and-talks-rare-disease" rel=" noopener noreferrer">Capricor’s CEO pursues a BLA and talks rare disease<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/48-the-first-half-of-2024-was-strong-as-m-as-and-financings-dominate" rel=" ">The first half of 2024 was strong as M&As and financings dominate<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/47-the-cost-of-delays-in-development-and-sales-it-s-probably-not-what-you-think" rel=" ">The cost of delays in development and sales: It’s probably not what you think</a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/46-asco-preview-adcs-and-radiotherapies-at-the-forefront-of-this-year-s-conference" rel=" " target="_self">ASCO preview: ADCs and radiotherapies at the forefront of this year’s conference<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/45-fibrobiologics-walks-the-unconventional-financing-path" rel=" " target="_self">Fibrobiologics walks the unconventional financing path<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/44-back-to-fundamentals-the-latest-numbers-point-to-better-times" rel=" " target="_self">Back to fundamentals: The latest numbers point to better times<br></a></li> </ul> <p class="regulatory__teaser"> <a href="https://www.bioworld.com/media/podcasts/532?audio_file_id=0&id_raw=532&page=1"><u>View all</u></a> </p> </td></tr></tbody></table></div></section><section class="topics-cta__wrapper"><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld</h1><div class="topics-cta__teaser">The news source of record covering the development of innovative human therapies for 25+ years</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld MedTech</h1><div class="topics-cta__teaser">Actionable and timely intelligence on advances in medical devices and technologies for 20+ years</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld Asia</h1><div class="topics-cta__teaser">A weekly monitor of biopharmaceutical news from the industry’s fastest-growing region</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld Science</h1><div class="topics-cta__teaser">Essential discovery and preclinical research news to support crucial drug R&D decisions at the earliest stages</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld Premium</h1><div class="topics-cta__teaser">Enjoy extended coverage for the most complete market view with BioWorld, BioWorld MedTech, and BioWorld Asia in a single, easy to access subscription</div><a class="topics-cta__link" href="/order">Subscribe</a></div></section></div><footer class="main-footer"><div class="main-footer__top"><nav id="footer-1" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="BioWorld|/topics/84-bioworld" href="/topics/84-bioworld">BioWorld</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Today's news|/topics/84-bioworld" href="/topics/84-bioworld">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Analysis and data insight|/articles/topic/84,109-analysis-and-data-insight-bioworld" href="/articles/topic/84,109-analysis-and-data-insight-bioworld">Analysis and data insight</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Clinical|/articles/topic/84,153-clinical-bioworld" href="/articles/topic/84,153-clinical-bioworld">Clinical</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Data Snapshots|/snapshots" href="/snapshots">Data Snapshots</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Deals and M&A|/articles/topic/84,214-deals-bioworld" href="/articles/topic/84,214-deals-bioworld">Deals and M&A</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Financings|/articles/topic/84,292-financings-bioworld" href="/articles/topic/84,292-financings-bioworld">Financings</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Newco news|/articles/topic/84,391-newco-news-bioworld" href="/articles/topic/84,391-newco-news-bioworld">Newco news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Opinion|/blogs/1-bioworld-perspectives" href="/blogs/1-bioworld-perspectives">Opinion</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Regulatory|/articles/topic/84,402-regulatory-bioworld" href="/articles/topic/84,402-regulatory-bioworld">Regulatory</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Science|/articles/topic/84,110-science-bioworld" href="/articles/topic/84,110-science-bioworld">Science</a></li></ul></li></ul></div></nav><nav id="footer-2" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="BioWorld MedTech|/topics/85-bioworld-medtech" href="/topics/85-bioworld-medtech">BioWorld MedTech</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Today's news|/topics/85-bioworld-medtech" href="/topics/85-bioworld-medtech">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Clinical|/articles/topic/85,153-clinical-bioworld-medtech" href="/articles/topic/85,153-clinical-bioworld-medtech">Clinical</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Data Snapshots|/medtech_snapshots" href="/medtech_snapshots">Data Snapshots</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Deals and M&A|/articles/topic/85,214-deals-bioworld-medtech" href="/articles/topic/85,214-deals-bioworld-medtech">Deals and M&A</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Financings|/articles/topic/85,292-financings-bioworld-medtech" href="/articles/topic/85,292-financings-bioworld-medtech">Financings</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Newco news|/articles/topic/85,391-newco-news-bioworld-medtech" href="/articles/topic/85,391-newco-news-bioworld-medtech">Newco news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Opinion|/blogs/2-bioworld-medtech-perspectives" href="/blogs/2-bioworld-medtech-perspectives">Opinion</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Regulatory|/articles/topic/85,402-regulatory-bioworld-medtech" href="/articles/topic/85,402-regulatory-bioworld-medtech">Regulatory</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Science|/articles/topic/85,110-science-bioworld-medtech" href="/articles/topic/85,110-science-bioworld-medtech">Science</a></li></ul></li></ul></div></nav><nav id="footer-3" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="BioWorld Asia|/topics/86-bioworld-asia" href="/topics/86-bioworld-asia">BioWorld Asia</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Today's news|/topics/86-bioworld-asia" href="/topics/86-bioworld-asia">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Analysis and data insight|/articles/topic/86,109-analysis-and-data-insight-bioworld-asia" href="/articles/topic/86,109-analysis-and-data-insight-bioworld-asia">Analysis and data insight</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Australia|/articles/topic/86,394-australia-bioworld-asia" href="/articles/topic/86,394-australia-bioworld-asia">Australia</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="China|/articles/topic/86,395-china-bioworld-asia" href="/articles/topic/86,395-china-bioworld-asia">China</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Clinical|/articles/topic/86,153-clinical-bioworld-asia" href="/articles/topic/86,153-clinical-bioworld-asia">Clinical</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Deals and M&A|/articles/topic/86,214-deals-bioworld-asia" href="/articles/topic/86,214-deals-bioworld-asia">Deals and M&A</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Financings|/articles/topic/86,292-financings-bioworld-asia" href="/articles/topic/86,292-financings-bioworld-asia">Financings</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Newco news|/articles/topic/86,391-newco-news-bioworld-asia" href="/articles/topic/86,391-newco-news-bioworld-asia">Newco news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Regulatory|/articles/topic/86,402-regulatory-bioworld-asia" href="/articles/topic/86,402-regulatory-bioworld-asia">Regulatory</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Science|/articles/topic/86,110-science-bioworld-asia" href="/articles/topic/86,110-science-bioworld-asia">Science</a></li></ul></li></ul></div></nav><nav id="footer-5" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="BioWorld Science|/topics/520-bioworld-science" href="/topics/520-bioworld-science">BioWorld Science</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Today's news|/topics/520-bioworld-science" href="/topics/520-bioworld-science">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Biomarkers|/articles/topic/520,543-biomarkers-bioworld-science" href="/articles/topic/520,543-biomarkers-bioworld-science">Biomarkers</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Cancer|/articles/topic/520,239-cancer-bioworld-science" href="/articles/topic/520,239-cancer-bioworld-science">Cancer</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Conferences|/articles/topic/520,154-conferences-bioworld-science" href="/articles/topic/520,154-conferences-bioworld-science">Conferences</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Endocrine/Metabolic|/articles/topic/520,246-endocrine-metabolic-bioworld-science" href="/articles/topic/520,246-endocrine-metabolic-bioworld-science">Endocrine/Metabolic</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Immune|/articles/topic/520,250-immune-bioworld-science" href="/articles/topic/520,250-immune-bioworld-science">Immune</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Infection|/articles/topic/520,251-infection-bioworld-science" href="/articles/topic/520,251-infection-bioworld-science">Infection</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Neurology/Psychiatric|/articles/topic/520,256-neurology-psychiatric-bioworld-science" href="/articles/topic/520,256-neurology-psychiatric-bioworld-science">Neurology/Psychiatric</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Patents|/articles/topic/520,472-patents-bioworld-science" href="/articles/topic/520,472-patents-bioworld-science">Patents</a></li></ul></li></ul></div></nav><nav id="footer-4" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="More|javascript:void(0);" href="javascript:void(0);">More</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="About|/about" href="/about">About</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Advertise with BioWorld|/advertising" href="/advertising">Advertise with BioWorld</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Archives|/newsletters" href="/newsletters">Archives</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Article reprints and permissions|/reprints" href="/reprints">Article reprints and permissions</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Contact us|https://clarivate.com/cortellis/contact-us/" target="_blank" href="https://clarivate.com/cortellis/contact-us/">Contact us</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Cookie policy|https://clarivate.com/legal/cookie-policy/" target="_blank" href="https://clarivate.com/legal/cookie-policy/">Cookie policy</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Copyright notice|https://clarivate.com/legal/copyright-notice/" target="_blank" href="https://clarivate.com/legal/copyright-notice/">Copyright notice</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Data methodology|/content/methodology-chart" href="/content/methodology-chart">Data methodology</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Infographics: Dynamic digital data analysis|/infographics-index" href="/infographics-index">Infographics: Dynamic digital data analysis</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Podcasts|/media/podcasts/532-bioworld-insider-podcast" href="/media/podcasts/532-bioworld-insider-podcast">Podcasts</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Privacy policy|https://clarivate.com/legal/privacy-policy/" target="_blank" href="https://clarivate.com/legal/privacy-policy/">Privacy policy</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Share your news with BioWorld|/share_your_news" href="/share_your_news">Share your news with BioWorld</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Staff|/staff" href="/staff">Staff</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Terms of use|https://clarivate.com/legal/terms-of-use/" target="_blank" href="https://clarivate.com/legal/terms-of-use/">Terms of use</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Topic alerts|/rss" href="/rss">Topic alerts</a></li></ul></li></ul></div></nav></div><div class="main-footer__bottom"><a class="social-media-links" title="Follow us" href="/social-media"><div class="social-media-links__callout">Follow Us</div><div class="social-media-links__twitter"></div> <div class="social-media-links__linkedin"></div></a></div><p class="main-footer__copyright">Copyright ©2025. All Rights Reserved. Design, CMS, Hosting & Web Development :: <a href="http://www.epublishing.com" target="_blank">ePublishing</a><br /><button class="ot-sdk-show-settings" id="ot-sdk-btn" style="margin-top: 1rem">Cookie Settings</button></p></footer></div> <script async="async"> //<![CDATA[ require(['bundle/main.bundle']); //]]> </script> </body></html>