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href="http://jamanetwork.com/collections/42132/retinal-disorders">Retinal Disorders</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2825835">Full Text</a> <span>|</span> <a href="/journals/jamaophthalmology/articlepdf/2825835/jamaophthalmology_abuzaitoun_2024_oi_240071_1730236529.70183.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825835" data-article-url="/journals/jamaophthalmology/articlepdf/2825835/jamaophthalmology_abuzaitoun_2024_oi_240071_1730236529.70183.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> </div> </div> </li> <li class="article bd-jama-otolaryngology–head--neck-surgery"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2825856">Polygenic Risk Scores and Hearing Loss Phenotypes in Children</a> <div class="article--pub-name meta-item">JAMA Otolaryngology–Head & Neck Surgery</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">November 7, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This cross-sectional study examines the association of polygenic risk scores for self-reported hearing difficulty in adults with hearing loss phenotypes in childhood.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5775/neurogenetics">Neurogenetics</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5777/neurology">Neurology</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5811/otolaryngology">Otolaryngology</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/42098/audiology-and-hearing">Audiology and Hearing</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5843/pediatrics">Pediatrics</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2825856">Full Text</a> <span>|</span> <a href="/journals/jamaotolaryngology/articlepdf/2825856/jamaotolaryngology_wang_2024_oi_240079_1730308359.91474.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825856" data-article-url="/journals/jamaotolaryngology/articlepdf/2825856/jamaotolaryngology_wang_2024_oi_240079_1730308359.91474.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> </div> </div> </li> <li class="article bd-jama-cardiology"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2825839">Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease</a> <div class="article--pub-name meta-item">JAMA Cardiology</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">November 6, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This genomewide association study examined specific genetic variants, pathways, and tissues associated with aortic stenosis independent of coronary artery disease in a meta-analysis of participants from 3 European cohorts.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5547/valvular-heart-disease">Valvular Heart Disease</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5548/cardiology">Cardiology</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/42118/ischemic-heart-disease">Ischemic Heart Disease</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamacardiology/fullarticle/2825839">Full Text</a> <span>|</span> <a href="/journals/jamacardiology/articlepdf/2825839/jamacardiology_trenkwalder_2024_oi_240063_1730239161.36026.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825839" data-article-url="/journals/jamacardiology/articlepdf/2825839/jamacardiology_trenkwalder_2024_oi_240063_1730239161.36026.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> </div> </div> </li> <li class="article bd-jama-network-open"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825808">Clinical Variant Reclassification in Hereditary Disease Genetic Testing</a> <div class="article--pub-name meta-item">JAMA Network Open</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">November 6, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This cohort study analyzes the rates at which clinical genetic variants are reclassified and the types of evidence that enable reclassification among individuals who undergo genetic testing for hereditary disease.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825808">Full Text</a> <span>|</span> <a href="/journals/jamanetworkopen/articlepdf/2825808/kobayashi_2024_oi_241272_1730219461.91463.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825808" data-article-url="/journals/jamanetworkopen/articlepdf/2825808/kobayashi_2024_oi_241272_1730219461.91463.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> <span class="badge icon-open_access"><span class="sr-t">open access</span></span> </div> </div> </li> <li class="article bd-jama-dermatology"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamadermatology/fullarticle/2825851">Use of Anti-PD1 Blockade After Hedgehog Inhibitors or as First-Line Therapy for Gorlin Syndrome</a> <div class="article--pub-name meta-item">JAMA Dermatology</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">November 6, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This case series examines treatment with anti–programmed cell death 1 (PD1) immunotherapy for patients with basal cell nevus syndrome.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5529/congenital-defects">Congenital Defects</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5598/dermatology">Dermatology</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5784/nevi">Nevi</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5786/targeted-and-immune-therapy">Targeted and Immune Therapy</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5801/oncology">Oncology</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamadermatology/fullarticle/2825851">Full Text</a> <span>|</span> <a href="/journals/jamadermatology/articlepdf/2825851/jamadermatology_reschke_2024_ld_240024_1730307633.14915.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825851" data-article-url="/journals/jamadermatology/articlepdf/2825851/jamadermatology_reschke_2024_ld_240024_1730307633.14915.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> </div> </div> </li> <li class="article bd-jama-network-open"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825633">Disaggregated Cancer Research and Intervention for Asian American and Pacific Islander Populations</a> <div class="article--pub-name meta-item">JAMA Network Open</div> <div class="article--type meta-item">Opinion</div> <div class="article--date meta-item no-wrap">November 4, 2024</div> <div class="article--excerpt"></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/46387/equity-diversity-and-inclusion">Equity, Diversity, and Inclusion</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5571/colorectal-cancer">Colorectal Cancer</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5655/gastroenterology">Gastroenterology</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5657/gastrointestinal-cancer">Gastrointestinal Cancer</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5679/health-disparities">Health Disparities</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825633">Full Text</a> <span>|</span> <a href="/journals/jamanetworkopen/articlepdf/2825633/dee_2024_ic_240255_1729873085.31392.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825633" data-article-url="/journals/jamanetworkopen/articlepdf/2825633/dee_2024_ic_240255_1729873085.31392.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> <span class="badge icon-open_access"><span class="sr-t">open access</span></span> </div> </div> </li> <li class="article bd-jama-network-open"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825627">Actionable Structural Variant Detection via RNA-NGS and DNA-NGS in Patients With Advanced Non–Small Cell Lung Cancer</a> <div class="article--pub-name meta-item">JAMA Network Open</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">November 4, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This cohort study assesses clinical evidence from patients with advanced lung adenocarcinoma and compares the detection of National Comprehensive Cancer Network–recommended actionable structural variants (aSVs) via concurrent DNA next-generation sequencing (NGS) and RNA-NGS vs DNA-NGS alone.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5801/oncology">Oncology</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/38786/cancer-genetics">Cancer Genetics</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5542/cancer-biomarkers">Cancer Biomarkers</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5725/lung-cancer">Lung Cancer</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825627">Full Text</a> <span>|</span> <a href="/journals/jamanetworkopen/articlepdf/2825627/owen_2024_oi_241229_1729873071.76436.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825627" data-article-url="/journals/jamanetworkopen/articlepdf/2825627/owen_2024_oi_241229_1729873071.76436.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> <span class="badge icon-open_access"><span class="sr-t">open access</span></span> </div> </div> </li> <li class="article bd-jama-network-open"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825629">US Cancer Mortality Trends Among Asian and Pacific Islander Populations</a> <div class="article--pub-name meta-item">JAMA Network Open</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">November 4, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This cross-sectional study evaluates longitudinal cancer mortality trends among Asian American and Pacific Islander populations in the US by demographic characteristics.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/46387/equity-diversity-and-inclusion">Equity, Diversity, and Inclusion</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/44020/health-policy">Health Policy</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/46328/health-inequities">Health Inequities</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5916/research-methods-statistics">Research, Methods, Statistics</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5801/oncology">Oncology</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825629">Full Text</a> <span>|</span> <a href="/journals/jamanetworkopen/articlepdf/2825629/zhu_2024_oi_241220_1729873077.65161.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825629" data-article-url="/journals/jamanetworkopen/articlepdf/2825629/zhu_2024_oi_241220_1729873077.65161.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> <span class="badge icon-open_access"><span class="sr-t">open access</span></span> </div> </div> </li> <li class="article bd-jama-pediatrics"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamapediatrics/fullarticle/2825495">Time Trends in the Burden of Environmental Heat and Cold Exposure Among Children and Adolescents</a> <div class="article--pub-name meta-item">JAMA Pediatrics</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">November 4, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This cross-sectional study reports on environmental heat and cold exposure–related burden and analyzes its temporal trends among children and adolescents from 1990 to 2019 using data from the Global Burden of Disease Study 2019.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5843/pediatrics">Pediatrics</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5495/adolescent-medicine">Adolescent Medicine</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5702/infectious-diseases">Infectious Diseases</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/46387/equity-diversity-and-inclusion">Equity, Diversity, and Inclusion</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5670/global-health">Global Health</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamapediatrics/fullarticle/2825495">Full Text</a> <span>|</span> <a href="/journals/jamapediatrics/articlepdf/2825495/jamapediatrics_he_2024_oi_240077_1730388836.9042.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825495" data-article-url="/journals/jamapediatrics/articlepdf/2825495/jamapediatrics_he_2024_oi_240077_1730388836.9042.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> </div> </div> </li> <li class="article bd-jama"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jama/fullarticle/2825534">Ovarian Odyssey</a> <div class="article--pub-name meta-item">JAMA</div> <div class="article--type meta-item">Opinion</div> <div class="article--date meta-item no-wrap">October 31, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>In this narrative medicine essay, a pediatrician thwarted a likely fatal cancer after undergoing genetic testing after noticing a pattern in her family that turned out to be caused by a genetic variation.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5514/humanities">Humanities</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5558/pediatric-cancer">Pediatric Cancer</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5766/narrative-medicine">Narrative Medicine</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/38786/cancer-genetics">Cancer Genetics</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/44046/a-piece-of-my-mind">A Piece of My Mind</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jama/fullarticle/2825534">Full Text</a> <span>|</span> <a href="/journals/jama/articlepdf/2825534/jama_di_maggio_2024_po_240037_1729804592.94258.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825534" data-article-url="/journals/jama/articlepdf/2825534/jama_di_maggio_2024_po_240037_1729804592.94258.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> </div> </div> </li> <li class="article bd-jama-psychiatry"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2825462">Sexual Trauma, Polygenic Scores, and Mental Health Diagnoses and Outcomes</a> <div class="article--pub-name meta-item">JAMA Psychiatry</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">October 30, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This genetic association study examined the associations between sexual trauma, polygenic liability to mental health outcomes, and clinical diagnoses of schizophrenia, bipolar disorder, and major depressive disorder in a clinical biobank setting.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5871/psychiatry-and-behavioral-health">Psychiatry and Behavioral Health</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/42137/trauma-and-stressor-related-psychiatric-disorders">Trauma- and Stressor-Related Psychiatric Disorders</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/42134/schizophrenia-spectrum-and-other-psychotic-disorders">Schizophrenia Spectrum and Other Psychotic Disorders</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5595/depressive-disorders">Depressive Disorders</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/5528/bipolar-and-related-disorders">Bipolar and Related Disorders</a> </div> <div class="article--bottom"> <div class="article--formats"> <a href="https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2825462">Full Text</a> <span>|</span> <a href="/journals/jamapsychiatry/articlepdf/2825462/jamapsychiatry_lake_2024_oi_240068_1729697256.24592.pdf" class="pdfaccess-text js-pdfaccess" title="PDF of article" data-article-id="2825462" data-article-url="/journals/jamapsychiatry/articlepdf/2825462/jamapsychiatry_lake_2024_oi_240068_1729697256.24592.pdf" data-ajax-url="/Content/CheckPdfAccess"><span class="icon-pdf"><span class="sr-t">pdf link</span></span> PDF</a> <span class="badge icon-open_access"><span class="sr-t">open access</span></span> </div> </div> </li> <li class="article bd-jama-network-open"> <a class="article--title d-b mb05" href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825342">Male Gender Expressivity and Diagnosis and Treatment of Cardiovascular Disease Risks in Men</a> <div class="article--pub-name meta-item">JAMA Network Open</div> <div class="article--type meta-item">Research</div> <div class="article--date meta-item no-wrap">October 25, 2024</div> <div class="article--excerpt"><Content><abstract abstract-type="teaser"><p>This cohort study examines the association between male gender expressivity--a measure reflecting sociocultural pressures to convey male gender identity--during adolescence and adulthood and diagnosis and treatment of cardiovascular disease (CVD) risks in men.</p></abstract></Content></div> <div class="topic-suggestions personalized-topics"> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/42128/public-health">Public Health</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/46327/lgbtqia-medicine">LGBTQIA Medicine</a> <a class="topic-suggestion personalized-topic no-wrap" href="http://jamanetwork.com/collections/46387/equity-diversity-and-inclusion">Equity, Diversity, and Inclusion</a> <a 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