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Use of Anti-PD1 Blockade After Hedgehog Inhibitors or as First-Line Therapy for Gorlin Syndrome | Congenital Defects | JAMA Dermatology | JAMA Network

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data-type="array"></span> <span class="hide tagmanagervalue" data-attribute="articleDOI" data-value="10.1001/jamadermatol.2024.4445" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="articleTitle" data-value="Use of Anti-PD1 Blockade After Hedgehog Inhibitors or as First-Line Therapy for Gorlin Syndrome" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="type" data-value="Research Letter" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="publishDate" data-value="November 6, 2024" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="topics" data-value="Congenital Defects, Dermatology, Genetics and Genomics, Nevi, Targeted and Immune Therapy, Oncology, Pediatrics, Skin Cancer, Cancer Genetics, Dental Medicine" data-type="array"></span> <span class="hide tagmanagervalue" data-attribute="topicCode" data-value="5529, 5598, 5664, 5784, 5786, 5801, 5843, 5906, 38786, 44019" data-type="array"></span> <span class="hide tagmanagervalue" data-attribute="category" data-value="Research" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="journalClub" data-value="No" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="contentStatus" data-value="Locked" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="articlePubState" data-value="Final" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="contentMedium" data-value="Article" data-type="string"></span> <div class="meta-article-type-wrap"> <div class="meta-article-type thm-col">Research Letter </div> </div> <div class="meta-date"><span class="epreprint"><span class="month">November </span><span class="day">6, </span><span class="year">2024</span></span></div> <div class="meta-article-title-wrap"> <h1 class="meta-article-title ">Use of Anti-PD1 Blockade After Hedgehog Inhibitors or as First-Line Therapy for Gorlin Syndrome</h1> </div> <div class="meta-authors"> <span class="meta-authors--limited"><span class="wi-fullname brand-fg"><a href="/searchresults?author=Robin+Reschke&q=Robin+Reschke" rel=nofollow target="_blank">Robin Reschke, MD<sup>1,2,3</sup></a></span><span class='al-author-delim'>; </span><span class="wi-fullname brand-fg"><a href="/searchresults?author=Jasmin+Richter&q=Jasmin+Richter" rel=nofollow target="_blank">Jasmin Richter<sup>1</sup></a></span><span class='al-author-delim'>; </span><span class="wi-fullname brand-fg"><a href="/searchresults?author=Alexander+H.+Enk&q=Alexander+H.+Enk" rel=nofollow target="_blank">Alexander H. Enk, MD<sup>1</sup></a></span>; <a class="meta-authors--etal td-u stats-meta-authors--etal">et al</a></span> <span class="meta-authors--remaining"><span class="wi-fullname brand-fg"><a href="/searchresults?author=Jessica+C.+Hassel&q=Jessica+C.+Hassel" rel=nofollow target="_blank">Jessica C. Hassel, MD<sup>1,2,3</sup></a></span></span> </div> <div class="meta-author"> <a class="meta-author-title is-b stats-meta-author-toggle" data-tog-target=".meta-author-content">Author Affiliations</a> <a class="meta-articleinfo-jumplink section-jump-link scroll-to stats-scroll-to-articleinfo" data-tab-toggle=".tab-nav-full-text" href="#249982982">Article Information</a> <div class="meta-author-content"> <ul class="meta-author-affiliations"> <li class="meta-author-affiliation"> <div class="meta-author-name"><sup>1</sup>Medical Faculty Heidelberg, Department of Dermatology and National Center for Tumor Diseases, Heidelberg University, Heidelberg, Germany</div> </li> <li class="meta-author-affiliation"> <div class="meta-author-name"><sup>2</sup>German Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany</div> </li> <li class="meta-author-affiliation"> <div class="meta-author-name"><sup>3</sup>German Cancer Research Center, Heidelberg, Germany</div> </li> </ul> </div> </div> <div class="meta-citation-wrap"> <span class="meta-citation-journal-name">JAMA Dermatol. </span><span class="meta-citation"> Published online November 6, 2024. doi:10.1001/jamadermatol.2024.4445</span> </div> </div> <div class="widget-EditorsChoice widget-instance-AMA_EditorsChoice_Links"> </div> <div class="widget-LinkedContentToolbar widget-instance-AMA_LinkedContentToolbar"> <div class="linked-content-toolbar"> <div class="hidden js-search-open-multimedia-by-default" showContentByDefault="False"></div> <div class="linked-content-controls"> <a class="linked-content-trigger td-n stats-graphical-abstract" href="#graphical-abstract-tab"> <i class="icon-visual-abstract"><span class="sr-t">visual abstract icon</span></i> <div class="trigger-text d-ib va-m ta-l fw-5">Visual <div>Abstract</div></div> </a> <a class="linked-content-trigger td-n stats-editorial-comment" href="#editorial-comment-tab"> <i class="icon-document"><span class="sr-t">editorial comment icon</span></i> <div class="trigger-text d-ib va-m ta-l fw-5">Editorial 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Despite the effectiveness of hedgehog inhibitors (HHIs), their associated toxic effects and the development of resistance are associated with high discontinuation rates as high as 90%.<sup><a href="#dld240024r1" class="ref-link section-jump-link" data-tab-toggle=".tab-nav-references">1</a></sup> This study presents what is to our knowledge the first dataset from 5 patients with BCNS who were treated with anti–programmed cell death 1 (PD1) immunotherapy, potentially offering insight into this alternative treatment option.</p> <div class="movable-ad-target bta"> </div> </div> </div> <div class="widget-ArticleLinks widget-instance-AMA_Abstract_EditorialComments"> </div> <a class="full-text-link is-b d-b bd-none ta-c fl-n radius mt1 mb1 m-auto" data-url="" data-article-id="2825851"> <div class="full-text-link--text fw-b"><span class="full-text-link--text-top">Full </span>Text</div> </a> <div class="seamless-access-button--mobile-only"> <div class="widget-AmaAdvancedSeamlessAccess 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