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class="wp-site-blocks"><header class="header wp-block-template-part"> <div class="wp-block-group header__content is-layout-flow wp-block-group-is-layout-flow"><div class="header__logo wp-block-site-logo"><a href="https://admescope.com/" class="custom-logo-link" rel="home"><img width="240" height="55" src="https://admescope.com/wp-content/uploads/sites/2/2023/06/logo-admescope-2023.svg" class="custom-logo" alt="Admescope" decoding="async" /></a></div> <div id="mega-menu-wrap-max_mega_menu_1" class="mega-menu-wrap"><div class="mega-menu-toggle"><div class="mega-toggle-blocks-left"></div><div class="mega-toggle-blocks-center"></div><div class="mega-toggle-blocks-right"><div class='mega-toggle-block mega-menu-toggle-animated-block mega-toggle-block-0' id='mega-toggle-block-0'><button aria-label="Toggle Menu" class="mega-toggle-animated mega-toggle-animated-slider" type="button" aria-expanded="false"> <span class="mega-toggle-animated-box"> <span class="mega-toggle-animated-inner"></span> 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class="hero__heading"> <h1>Symeres</h1> </div> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group main__content is-layout-constrained wp-block-group-is-layout-constrained"> <div id="ez-toc-container" class="ez-toc-v2_0_69_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction"> <div class="ez-toc-title-container"> <p class="ez-toc-title" style="cursor:inherit">Table of Contents</p> <span class="ez-toc-title-toggle"></span></div> <nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-1" href="#Drug_Discovery" title="Drug Discovery">Drug Discovery</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-2" href="#Synthetic_Chemistry" title="Synthetic Chemistry">Synthetic Chemistry</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-3" href="#API_Development" title="API Development">API Development</a></li></ul></nav></div> <div class="entry-content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <p class="has-medium-font-size"><a data-type="URL" data-id="https://symeres.com/" href="https://symeres.com/" target="_blank" rel="noreferrer noopener">Symeres</a> is the leading mid-sized trans-Atlantic contract research organization for your drug discovery and development needs. With over 600 scientists at several locations (Groningen, Nijmegen, Weert and Oss in the Netherlands, Prague in the Czech Republic, Boston and Princeton in USA and Oulu in Finland) Symeres offers best-in-class solutions for drug discovery and drug development for small molecules and beyond.</p> <p class="has-medium-font-size">The services span from early-stage hit finding all the way to the delivery of your early clinical drug substance API. At Symeres, deep scientific knowledge base is blend with creativity to deliver the quality results your project needs.</p> <figure class="wp-block-image size-large is-resized"><img decoding="async" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/05/Symeres_Purple_Blue-1024x293.png" alt="Symeres logo - Symeres offers best-in-class solutions for drug discovery and drug development for small molecules and beyond" class="wp-image-1042" width="380" height="109" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/05/Symeres_Purple_Blue-1024x293.png 1024w, https://admescope.com/wp-content/uploads/sites/2/2023/05/Symeres_Purple_Blue-300x86.png 300w, https://admescope.com/wp-content/uploads/sites/2/2023/05/Symeres_Purple_Blue-768x220.png 768w, https://admescope.com/wp-content/uploads/sites/2/2023/05/Symeres_Purple_Blue-1536x440.png 1536w, https://admescope.com/wp-content/uploads/sites/2/2023/05/Symeres_Purple_Blue.png 1728w" sizes="(max-width: 380px) 100vw, 380px" /></figure> <h4 class="wp-block-heading has-medium-font-size"><span class="ez-toc-section" id="Drug_Discovery"></span><strong>Drug Discovery</strong><span class="ez-toc-section-end"></span></h4> <p class="has-medium-font-size">Symeres delivers best-in-class chemistry solutions for drug discovery and early drug development. The <a href="https://symeres.com/services/drug-discovery/" target="_blank" rel="noreferrer noopener">discovery services</a> span from early stage hit finding to clinical candidate identification. Symeres also partners with leading CROs for specific biological platforms, offering an integrated solution to your drug discovery needs.</p> <h4 class="wp-block-heading has-medium-font-size"><span class="ez-toc-section" id="Synthetic_Chemistry"></span><strong>Synthetic Chemistry</strong><span class="ez-toc-section-end"></span></h4> <p class="has-medium-font-size">Symeres offers high-quality services for synthetic chemistry and preparation of research compounds, including extensive experience in metabolite synthesis. The <a href="https://symeres.com/services/synthetic-chemistry/" target="_blank" rel="noreferrer noopener">synthesis services</a> span from route design to milligram- and kilogram-scale supply of materials, for any application where complex molecules matter.</p> <h4 class="wp-block-heading has-medium-font-size"><span class="ez-toc-section" id="API_Development"></span><strong>API Development</strong><span class="ez-toc-section-end"></span></h4> <p class="has-medium-font-size">With two separate non-GMP and cGMP supporting business units, Symeres is able to offer <a href="https://symeres.com/services/drug-development/" target="_blank" rel="noreferrer noopener">chemistry solutions for early drug development</a>. The services include route scouting, risk assessments, catalyst screens, solid-state chemistry, and early safety studies, to ensure that the route chosen for clinical supply will be robust, reliable, and ultimately scalable. Symeres delivers your early clinical drug substance API (phase I/II).</p> <figure class="wp-block-image size-large is-resized"><img fetchpriority="high" decoding="async" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-admescope-1024x587.png" alt="Chemistry solutions for early drug development" class="wp-image-696" width="768" height="440" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-admescope-1024x587.png 1024w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-admescope-300x172.png 300w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-admescope-768x440.png 768w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-admescope-1536x880.png 1536w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-admescope.png 1595w" sizes="(max-width: 768px) 100vw, 768px" /></figure> <p class="has-medium-font-size">More information about how we can support with <a href="https://symeres.com/?__hstc=116170073.11e3763ff583ba74de6af6e22c9be3c2.1683792673327.1685092172936.1685112071912.16&__hssc=116170073.7.1685112071912&__hsfp=3795293077">integrated drug discovery</a> services is available on Symeres website.</p> <figure class="wp-block-image size-large"><img decoding="async" width="1024" height="526" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-symeres-and-admescope-1-1024x526.png" alt="Integrated drug discovery聽services" class="wp-image-1046" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-symeres-and-admescope-1-1024x526.png 1024w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-symeres-and-admescope-1-300x154.png 300w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-symeres-and-admescope-1-768x395.png 768w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-symeres-and-admescope-1-1536x789.png 1536w, https://admescope.com/wp-content/uploads/sites/2/2023/05/integrated-drug-discovery-services-symeres-and-admescope-1-2048x1052.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></figure> </div></div> <section class="block block--primary"> <div class="block__content block__content--right"> <div class="block__text"> <h2>Feel free to contact us!</h2> <p><strong>Curious to know more about what can we do for you? 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src="//js-eu1.hs-scripts.com/25214463.js"></script>  </div></div> <section class="downloads__aside" id="sidebar-downloads"> <button class="downloads__label"> <span>0</span> <svg><use xlink:href="#icon-download"></use></svg> </button> <div class="downloads__content"> <button class="downloads__close" id="downloads-close"><svg xmlns:xlink="http://www.w3.org/1999/xlink"><title>Close this panel</title><use xlink:href="#icon-times"></use></svg></button> <div id="selected-files" class="downloads__files"> <h3>Files</h3> <div> <ul></ul> </div> <button style="margin-top:20px;" id="remove-all-files" type="submit" class="button">Remove all</button> </div> <form class="downloads__form form" action="https://admescope.com/wp-admin/admin-ajax.php" method="POST" id="symeresdownloads"> <p>Please, provide us your email address so that we can send you a link for downloading the requested files.</p> <div class="form__row"> <div class="form__col"> <label for="email">Email</label> <input id="email" name="email" type="email" placeholder="Email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script> jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); $('.downloads__content').css('display', 'flex'); }); $('body').on('change', 'form.downloads', function(){ let downloadsList = ''; let filenames = {}; $('input:checkbox[name=download]').each(function(){ filenames[$(this).data('filename')] = $(this).data('filetitle'); if (this.checked) { downloads[$(this).data('download')] = $(this).data('filename'); } else { if ($(this).data('download') in downloads) { delete downloads[$(this).data('download')]; } if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsFromLocalStorage) { delete downloadsFromLocalStorage[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsFromLocalStorage)); } } } $('input[name="downloaded_files"]').val(Object.values(filenames).join(',')); }); // set filenames + titles in localStorage if (Object.keys(filenames).length) { let filenamesJson = JSON.stringify(filenames); if (localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#symeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#symeresdownloads'); var email = $("#symeresdownloads :input[name='email']").val(); var firstName = $("#symeresdownloads :input[name='first-name']").val(); var lastName = $("#symeresdownloads :input[name='last-name']").val(); var company = $("#symeresdownloads :input[name='company']").val(); var action = $("#symeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#symeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#symeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ 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