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NIDDK Central Repository
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class="form-check-label">Doctoral Thesis/Dissertation (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="Journal" class="form-check-input"/><label title="" for="Journal" class="form-check-label">Journal (1783)</label></div></div></div></div></div></div><div tabindex="0" id="-1" aria-label="Study Acronym collapsable section" class=" Accordion_filterAccordion__FRmA3 accordion"><div class="undefined Accordion_filterItem__KJDOV accordion-item"><h2 class="undefined Accordion_filterHeader__RktDS accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed">Study Acronym</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_filterBody__n0i21 accordion-body"><div role="region" aria-live="polite"><div class="mb-3 row"><form class="FacetAggregate_clearIconContainer__2gP50"><input aria-label="Study Acronym filter search bar" type="text" placeholder="Search for filter..." value=""/><span><svg xmlns="http://www.w3.org/2000/svg" width="21" height="21" viewBox="0 0 21 21" fill="none"><circle cx="10.4286" cy="10.4286" r="9.92857" fill="white" stroke="#868686"></circle><path d="M15.2969 15.2958L5.56354 5.5625" stroke="#6C757D" stroke-width="2" stroke-miterlimit="10"></path><path d="M5.56354 15.2958L15.2969 5.5625" stroke="#6C757D" stroke-width="2" stroke-miterlimit="10"></path></svg></span></form></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="A2ALL" class="form-check-input"/><label title="" for="A2ALL" class="form-check-label">A2ALL (73)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="AALF" class="form-check-input"/><label title="" for="AALF" class="form-check-label">AALF (70)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="AASK Cohort" class="form-check-input"/><label title="" for="AASK Cohort" class="form-check-label">AASK Cohort (7)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="AASK Trial" class="form-check-input"/><label title="" for="AASK Trial" class="form-check-label">AASK Trial (14)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="ALTOLD" class="form-check-input"/><label title="" for="ALTOLD" class="form-check-label">ALTOLD (5)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="APRON" class="form-check-input"/><label title="" for="APRON" class="form-check-label">APRON (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="ASSESS-AKI" class="form-check-input"/><label title="" for="ASSESS-AKI" class="form-check-label">ASSESS-AKI (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="ATN" class="form-check-input"/><label title="" for="ATN" class="form-check-label">ATN (10)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="BACH" class="form-check-input"/><label title="" for="BACH" class="form-check-label">BACH (105)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="BARC" class="form-check-input"/><label title="" for="BARC" class="form-check-label">BARC (13)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="BASIC" class="form-check-input"/><label title="" for="BASIC" class="form-check-label">BASIC (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="BE-DRI" class="form-check-input"/><label title="" for="BE-DRI" class="form-check-label">BE-DRI (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CAMUS" class="form-check-input"/><label title="" for="CAMUS" class="form-check-label">CAMUS (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CDS" class="form-check-input"/><label title="" for="CDS" class="form-check-label">CDS (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CIT-01" class="form-check-input"/><label title="" for="CIT-01" class="form-check-label">CIT-01 (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CKiD" class="form-check-input"/><label title="" for="CKiD" class="form-check-label">CKiD (220)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CORI" class="form-check-input"/><label title="" for="CORI" class="form-check-label">CORI (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CRIC" class="form-check-input"/><label title="" for="CRIC" class="form-check-label">CRIC (73)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CRISP" class="form-check-input"/><label title="" for="CRISP" class="form-check-label">CRISP (20)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CUTIE" class="form-check-input"/><label title="" for="CUTIE" class="form-check-label">CUTIE (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CureGN" class="form-check-input"/><label title="" for="CureGN" class="form-check-label">CureGN (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="CyNCh" class="form-check-input"/><label title="" for="CyNCh" class="form-check-label">CyNCh (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="DCCT" class="form-check-input"/><label title="" for="DCCT" class="form-check-label">DCCT (200)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="DCCT/EDIC" class="form-check-input"/><label title="" for="DCCT/EDIC" class="form-check-label">DCCT/EDIC (19)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="DILIN Pro" class="form-check-input"/><label title="" for="DILIN Pro" class="form-check-label">DILIN Pro (9)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="DPP" class="form-check-input"/><label title="" for="DPP" class="form-check-label">DPP (32)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="DPPOS" class="form-check-input"/><label title="" for="DPPOS" class="form-check-label">DPPOS (14)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="DPT-1" class="form-check-input"/><label title="" for="DPT-1" class="form-check-label">DPT-1 (46)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="EPISOD" class="form-check-input"/><label title="" for="EPISOD" class="form-check-label">EPISOD (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FAVORIT" class="form-check-input"/><label title="" for="FAVORIT" class="form-check-label">FAVORIT (7)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FDTT" class="form-check-input"/><label title="" for="FDTT" class="form-check-label">FDTT (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FHN Daily" class="form-check-input"/><label title="" for="FHN Daily" class="form-check-label">FHN Daily (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FHN Nocturnal" class="form-check-input"/><label title="" for="FHN Nocturnal" class="form-check-label">FHN Nocturnal (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FIND" class="form-check-input"/><label title="" for="FIND" class="form-check-label">FIND (8)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FISTULA" class="form-check-input"/><label title="" for="FISTULA" class="form-check-label">FISTULA (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FLINT" class="form-check-input"/><label title="" for="FLINT" class="form-check-label">FLINT (3)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FONT II" class="form-check-input"/><label title="" for="FONT II" class="form-check-label">FONT II (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FSGS/FONT" class="form-check-input"/><label title="" for="FSGS/FONT" class="form-check-label">FSGS/FONT (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="FUSION" class="form-check-input"/><label title="" for="FUSION" class="form-check-label">FUSION (4)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="GLUMIT" class="form-check-input"/><label title="" for="GLUMIT" class="form-check-label">GLUMIT (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="GRAFT" class="form-check-input"/><label title="" for="GRAFT" class="form-check-label">GRAFT (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="GoKind" class="form-check-input"/><label title="" for="GoKind" class="form-check-label">GoKind (24)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="GpR" class="form-check-input"/><label title="" for="GpR" class="form-check-label">GpR (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HALT PKD" class="form-check-input"/><label title="" for="HALT PKD" class="form-check-label">HALT PKD (8)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HALT-C" class="form-check-input"/><label title="" for="HALT-C" class="form-check-label">HALT-C (10)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HAPO-FUS" class="form-check-input"/><label title="" for="HAPO-FUS" class="form-check-label">HAPO-FUS (5)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HBRN Cohort A" class="form-check-input"/><label title="" for="HBRN Cohort A" class="form-check-label">HBRN Cohort A (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HBRN Immune Active" class="form-check-input"/><label title="" for="HBRN Immune Active" class="form-check-label">HBRN Immune Active (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HBRN Immune Tolerant A" class="form-check-input"/><label title="" for="HBRN Immune Tolerant A" class="form-check-label">HBRN Immune Tolerant A (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HBRN Immune Tolerant P" class="form-check-input"/><label title="" for="HBRN Immune Tolerant P" class="form-check-label">HBRN Immune Tolerant P (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HEALTHY" class="form-check-input"/><label title="" for="HEALTHY" class="form-check-label">HEALTHY (14)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="HEMO" class="form-check-input"/><label title="" for="HEMO" class="form-check-label">HEMO (70)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="IBD" class="form-check-input"/><label title="" for="IBD" class="form-check-label">IBD (48)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="ICDB" class="form-check-input"/><label title="" for="ICDB" class="form-check-label">ICDB (29)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="LABS" class="form-check-input"/><label title="" for="LABS" class="form-check-label">LABS (98)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="LOGIC" class="form-check-input"/><label title="" for="LOGIC" class="form-check-label">LOGIC (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="LTD2" class="form-check-input"/><label title="" for="LTD2" class="form-check-label">LTD2 (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="LURN" class="form-check-input"/><label title="" for="LURN" class="form-check-label">LURN (5)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="Look AHEAD" class="form-check-input"/><label title="" for="Look AHEAD" class="form-check-label">Look AHEAD (11)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="MAPP I" class="form-check-input"/><label title="" for="MAPP I" class="form-check-label">MAPP I (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="MDRD" class="form-check-input"/><label title="" for="MDRD" class="form-check-label">MDRD (62)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="MTOPS" class="form-check-input"/><label title="" for="MTOPS" class="form-check-label">MTOPS (22)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="NAFLD Adult" class="form-check-input"/><label title="" for="NAFLD Adult" class="form-check-label">NAFLD Adult (4)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="NAFLD Pediatric" class="form-check-input"/><label title="" for="NAFLD Pediatric" class="form-check-label">NAFLD Pediatric (4)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="NANS" class="form-check-input"/><label title="" for="NANS" class="form-check-label">NANS (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="NEPTUNE" class="form-check-input"/><label title="" for="NEPTUNE" class="form-check-label">NEPTUNE (13)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="NORIG" class="form-check-input"/><label title="" for="NORIG" class="form-check-label">NORIG (23)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PALF" class="form-check-input"/><label title="" for="PALF" class="form-check-label">PALF (3)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PEDS-C" class="form-check-input"/><label title="" for="PEDS-C" class="form-check-label">PEDS-C (8)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PERL" class="form-check-input"/><label title="" for="PERL" class="form-check-label">PERL (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PIVENS" class="form-check-input"/><label title="" for="PIVENS" class="form-check-label">PIVENS (14)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PRESERVE" class="form-check-input"/><label title="" for="PRESERVE" class="form-check-label">PRESERVE (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PRIDE" class="form-check-input"/><label title="" for="PRIDE" class="form-check-label">PRIDE (21)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PROBE" class="form-check-input"/><label title="" for="PROBE" class="form-check-label">PROBE (120)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="PROTECT" class="form-check-input"/><label title="" for="PROTECT" class="form-check-label">PROTECT (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="RICE" class="form-check-input"/><label title="" for="RICE" class="form-check-label">RICE (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="RIVUR" class="form-check-input"/><label title="" for="RIVUR" class="form-check-label">RIVUR (3)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="SIGT" class="form-check-input"/><label title="" for="SIGT" class="form-check-label">SIGT (5)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="SISTEr" class="form-check-input"/><label title="" for="SISTEr" class="form-check-label">SISTEr (5)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="SPLIT" class="form-check-input"/><label title="" for="SPLIT" class="form-check-label">SPLIT (30)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="START" class="form-check-input"/><label title="" for="START" class="form-check-label">START (3)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="SyNCH" class="form-check-input"/><label title="" for="SyNCH" class="form-check-label">SyNCH (4)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="T1DGC" class="form-check-input"/><label title="" for="T1DGC" class="form-check-label">T1DGC (77)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="T1DGC-Special" class="form-check-input"/><label title="" for="T1DGC-Special" class="form-check-label">T1DGC-Special (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="TEDDY" class="form-check-input"/><label title="" for="TEDDY" class="form-check-label">TEDDY (43)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="TN01" class="form-check-input"/><label title="" for="TN01" class="form-check-label">TN01 (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="TN02" class="form-check-input"/><label title="" for="TN02" class="form-check-label">TN02 (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="TN05" class="form-check-input"/><label title="" for="TN05" class="form-check-label">TN05 (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="TN07" class="form-check-input"/><label title="" for="TN07" class="form-check-label">TN07 (2)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="TN08" class="form-check-input"/><label title="" for="TN08" class="form-check-label">TN08 (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="TN09" class="form-check-input"/><label title="" for="TN09" class="form-check-label">TN09 (1)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined 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id="Contributing Study" class="form-check-input"/><label title="" for="Contributing Study" class="form-check-label">Contributing Study (1834)</label></div></div><div class="undefined undefined Toggle_toggleContainer__t3y6e"><div class="undefined form-check"><input type="checkbox" id="Secondary Research" class="form-check-input"/><label title="" for="Secondary Research" class="form-check-label">Secondary Research (232)</label></div></div></div></div></div></div></div></div><div class="PublicationsExplorer_resultSection__MjfJ3 col-lg-9"><div class="mb-3 narrowTextBackground ResultActions_tableFunctionsContainer__DM_QE ResultActions_sidebarOpen__gnHcB row"><div class="ResultActions_rowAlign__aoDEJ"><div class="ResultActions_results__YlN54 undefined"><span class="ResultNumbers_bolded__hVqir">1 - 50</span><span class="ResultNumbers_text__DmiUL"> of 2066 Results</span><div class="Pagination_row__Gm3hz"><ul class="Pagination_pagination__BG_HW pagination"><li class="page-item disabled"><span 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aria-label="Download Results into an Excel Spreadsheet" class="Button_button__OFOdO Button_auto__peQWd Button_liteRounded__NxMDh ResultActions_tableFunctionButton__Qz7qZ ResultActions_download__RQnO6 Button_primary__WTwSy a a-primary"><span class="Button_iconLeft__dfwTS"><svg width="15" height="13" viewBox="0 0 15 13" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M13.8374 8.86925C13.6792 8.71158 13.4877 8.63281 13.262 8.63281H9.33759L8.18749 9.77963C7.85996 10.0939 7.47675 10.2514 7.03685 10.2514C6.59695 10.2514 6.21363 10.0944 5.88658 9.77963L4.74503 8.63281H0.812074C0.586529 8.63281 0.394885 8.71158 0.236696 8.86925C0.0790339 9.02639 0 9.21727 0 9.44219V12.14C0 12.3648 0.0790339 12.5558 0.236696 12.7129C0.394885 12.8701 0.586529 12.9488 0.812074 12.9488H13.262C13.4877 12.9488 13.6792 12.8701 13.8374 12.7129C13.995 12.5558 14.0741 12.3647 14.0741 12.14V9.44219C14.0741 9.21727 13.995 9.02639 13.8374 8.86925ZM10.6656 11.7101C10.5582 11.8167 10.4315 11.8702 10.285 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class="Table_table__b_0YI table table-sm table-striped table-bordered"><caption class="sr-only">Study Search Results Table</caption><thead><tr><th tabindex="0" colSpan="1" style="width:300px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">Title</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="transparent" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="transparent" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:130px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">PMID</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:130px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">PMCID</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:130px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">Public Release Type</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:150px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">Publication Year</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:150px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">DOI</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:130px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">Study Acronym</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:130px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">Request ID(s)</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th><th tabindex="0" colSpan="1" style="width:130px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_row__H0_2i"><div class="Table_sortTextHeader__PZjYh Table_textHeader__nU1f7">Public Release Origin</div><div class="Table_sortHeader__M9mVA"><a tabindex="0"><svg width="17" height="14" viewBox="0 0 17 14" fill="none" xmlns="http://www.w3.org/2000/svg"><g clip-path="url(#clip0_2495_34255)"><path d="M8.78516 4.46988L12.2503 1.46875L15.7419 4.46988" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M12.25 12.3402V2.34961" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M8.3111 9.31445L4.84596 12.3419L1.35437 9.31445" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path><path d="M4.84302 1.46875V11.4594" stroke="white" stroke-width="1.8" stroke-miterlimit="10"></path></g><defs><clipPath id="clip0_2495_34255"><rect width="15.7651" height="13.663" fill="white" transform="translate(0.664429 0.0722656)"></rect></clipPath></defs></svg></a></div></div></div></th></tr></thead><tbody><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2058">10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">19878986</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3135022</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2009</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/S0140-6736(09)61457-4</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DPPOS</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2928">130EBV Disease and Lymphoproliferative Disease (LPD) after a First Liver Transplant in Children Enrolled in the SPLIT Registry.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2000</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">SPLIT</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1942">30-day Mortality in the Longitudinal Assessment of Bariatric Surgery</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2010</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">LABS</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1673">5-year continence rates, satisfaction and adverse events of burch urethropexy and fascial sling surgery for urinary incontinence.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">22341290</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3586411</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2012</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/j.juro.2011.11.087</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">SISTEr</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1307">5-year longitudinal followup after retropubic and transobturator mid urethral slings.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">25158274</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC4272663</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2015</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/j.juro.2014.08.089</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">TOMUS</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2121">A Comparison Of 30 Day Outcomes After Primary And Revisional Bariatric Surgical Procedures From The Longitudinal Assessment Of Bariatric Surgery (LABS) Study</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2009</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">LABS</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/308">A Multistage Rigid-Affine-Deformable Network for Three-Dimensional Multimodal Medical Image Registration</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2023</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.3390/app132413298</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">CRISP</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">22433</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1053">A New Brief Clinical Assessment of Lower Urinary Tract Symptoms for Women and Men: LURN SI-10.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">31364922</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC6904437</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2020</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1097/JU.0000000000000465</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">LURN</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1860">A Novel Immunohiostochemical Staining Pattern for Keratin 8/18 Plus Ubiquitin in Nonalcoholic Fatty Liver Disease Is Associated with Increased Disease Severity and Advanced Fibrosis</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/162">A Novel Risk Engine for Diabetes-related Complications among Individuals with Type 1 Diabetes</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2022</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/j.jval.2022.04.1637</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DCCT/EDIC</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">22982</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1745">A Randomized, Placebo-Controlled Trial of Oral Silymarin (Milk Thistle) For Chronic Hepatitis C: Final Results of the SYNCH Multicenter Study.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1002/hep.24666</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">SyNCH</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1068">A Reanalysis of the RIVUR Trial Using a Risk Classification System.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">29198997</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2018</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/j.juro.2017.11.080</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">RIVUR</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">21155</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1138">A Three-Year Evaluation of Eating Pathology and Outcome in the LABS-3 Study</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2015</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">LABS</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1084">A blended link approach to relative risk regression.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">29298596</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2018</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1177/0962280217698174</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">20517</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1515">A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised nonalcoholic fatty liver disease</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2013</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2586">A case-control study of risk factors in men with chronic pelvic pain syndrome.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">16104910</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2005</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1111/j.1464-410X.2005.05684.x</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1651">A clinical trial to maintain glycemic control in youth with type 2 diabetes.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">22540912</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3478667</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2012</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1056/NEJMoa1109333</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">TODAY</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2572">A comparison of adult living donor (LDLT) to deceased donor liver transplant (DDLT) for hepatocellular carcinoma (HCC): data from the A2ALL study</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2005</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">A2ALL</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2632">A comparison of iothalamate-GFR and serum creatinine-based outcomes: acceleration in the rate of GFR decline in the African American Study of Kidney Disease and Hypertension.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">15579521</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2004</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1097/01.ASN.0000146688.74084.A3</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1849">A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">20522170</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC2955175</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1111/j.1399-5448.2010.00662.x</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DPT-1</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/3118">A comparison of the study populations in the Diabetes Control and Complications Trial and the Wisconsin Epidemiologic Study of Diabetic Retinopathy.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">7695463</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">1995</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DCCT</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/3049">A controlled analysis of the transjugular intrahepatic portosystemic shunt in liver transplant recipients. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Liver Transplantation Database.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">9133467</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">1997</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1097/00007890-199704270-00005</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2479">A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">17068223</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC4410764</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2006</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1126/science.1135245</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">IBD</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1267">A genome-wide association study identifies THBS2 as a candidate modifier of liver disease severity in Alagille syndrome</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2014</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2059">A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">19875614</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC2809960</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2010</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.2337/db09-0653</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DCCT</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2432">A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">17463248</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3214617</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2007</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1126/science.1142382</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">FUSION</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1757">A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">21980299</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3183083</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1371/journal.pgen.1002293</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">T1DGC</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1690">A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">22412388</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3297573</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2012</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1371/journal.pgen.1002559</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">IBD</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1557">A genome-wide survey of transgenerational genetic effects in autism.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">24204716</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3811986</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2013</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1371/journal.pone.0076978</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">IBD</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2362">A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">17931054</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2007</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1089/dia.2007.0229</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">TEDDY</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2257">A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">18647951</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC2551699</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2008</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.2337/db08-0753</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">T1DGC</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1066">A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">29444133</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC5812629</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2018</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1371/journal.pone.0192472</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DPP, DPPOS</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">20879</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1752">A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">21911777</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3198298</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.2337/dc11-0981</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DPT-1</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/231">A machine learning-based approach for predicting the outbreak of cardiovascular diseases in patients on dialysis</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">31319965</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2019</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/j.cmpb.2019.05.005</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">HEMO</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">21866</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/157">A meta-analysis of GFR slope as a surrogate endpoint for kidney failure</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">37330614</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2023</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1038/s41591-023-02418-0</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">HALT PKD, FSGS/FONT, FONT II</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">22864, 23584</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1218">A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">25884839</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC4377063</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2015</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1186/s12887-015-0333-8</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">TEDDY</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2871">A model for a proportional treatment effect on disease progression.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">11414556</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2001</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1111/j.0006-341x.2001.00354.x</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">MDRD</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1715">A molecular signature of biliary atresia highly distinct from other cholestatic diseases at diagnosis</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1958">A motivation-focused weight loss maintenance program is an effective alternative to a skill-based approach.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">20680012</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC2974962</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1038/ijo.2010.138</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PRIDE</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2647">A multi-center analysis of outcome at 24 months of age in children with biliary atresia in the United States</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2004</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2492">A multi-institutional study of interobserver agreement on the histologic diagnosis of biliary obstruction in liver biopsies of cholestatic infants less than six months of age</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2006</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE, BARC</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2541">A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">16647406</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2006</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/j.jpeds.2005.12.054</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE, BARC</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2440">A multimodality correlation of hepatic steatosis in NAFLD</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2007</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1786">A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">21606838</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2011</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1097/SLA.0b013e31821ad86a</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">SPLIT</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2577">A new defect in beta-oxidation presenting as sudden liver failure</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2005</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2621">A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Conference Presentation</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2005</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/2401">A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">17564966</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC1950923</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2007</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1086/519219</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PROBE</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1054">A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) questionnaire.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">31225927</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC6660359</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2019</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1002/nau.24067</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">LURN</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/132">A nomogram-based diabetic sensorimotor polyneuropathy severity prediction using Michigan neuropathy screening instrumentations</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">34715551</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2021</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1016/j.compbiomed.2021.104954</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">DPPOS</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">23125</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Secondary Research</span></td></tr><tr class=""><td tabindex="0" class="Table_alignLeft__VdU8l"><a class="PublicationsExplorer_bold__AmpYR" href="/publications/1708">A novel bayesian graphical model for genome-wide multi-SNP association mapping.</a></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">22127647</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">PMC3337957</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Journal</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">2012</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">10.1002/gepi.20661</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">IBD</span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR"></span></td><td tabindex="0" class="Table_alignLeft__VdU8l"><span class="PublicationsExplorer_bold__AmpYR">Contributing Study</span></td></tr></tbody></table></div></div><div class="mb-3 narrowTextBackground ResultActions_tableFunctionsContainer__DM_QE row"><div class="ResultActions_rowAlign__aoDEJ"><div class="ResultActions_results__YlN54 undefined"><div 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href="https://amt.coretrustseal.org/certificates">Core Trustworthy Data Repository</a></div></div></div></div></footer></div></div></div><script id="__NEXT_DATA__" type="application/json">{"props":{"pageProps":{"searchResults":{"took":55,"timed_out":false,"_shards":{"total":5,"successful":5,"skipped":0,"failed":0},"hits":{"total":{"value":2066,"relation":"eq"},"max_score":null,"hits":[{"_index":"publications_v001","_id":"Iv3kapMBC2xkvCSBWBZR","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":"10.1016/S0140-6736(09)61457-4","request_id":null,"study_name":"Diabetes Prevention Program Outcomes Study","author_array":["Weinzierl V","Williams-Cleaves B","Metzger BE","Molitch ME","Johnson MK","Giles MM","Larsen D","Niznik C","Pen SC","Schinleber PA","Nathan DM","McKitrick C","Turgeon H","Abbott K","Altshuler D","Anderson E","Bissett L","Cagliero E","D'Anna K","Delahanty L","Florez JC","Goldman V","Poulos A","Tseng B","Barrett-Connor E","Carrion-Petersen ML","Horne 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We investigated the persistence of these effects in the long term.","@timestamp":"2024-11-26T23:52:43.034Z","study_name_array":["Diabetes Prevention Program Outcomes Study"],"pmcid":"PMC3135022","publication_year":2009,"study_acronym_array":["DPPOS"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study."]},{"_index":"publications_v001","_id":"iP3kapMBC2xkvCSBVRUt","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":null,"request_id":null,"study_name":"Studies of Pediatric Liver Transplantation","author_array":["The SPLIT Research Group","McDiarmid SV","Anand R"],"@version":"1","id":2928,"title":"130EBV Disease and Lymphoproliferative Disease (LPD) after a First Liver Transplant in Children Enrolled in the SPLIT Registry.","pmid":null,"publication_type":"Journal","citation":"\u003cspan\u003eMcDiarmid SV, Anand R, The SPLIT Research Group. 130EBV Disease and Lymphoproliferative Disease (LPD) after a First Liver Transplant in Children Enrolled in the SPLIT Registry. \u003ci\u003eLiver Transplant\u003c/i\u003e 2000;6(3):C33.\u003c/span\u003e","author":"The SPLIT Research Group, McDiarmid SV, Anand R","study_acronym":"SPLIT","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:42.996Z","study_name_array":["Studies of Pediatric Liver Transplantation"],"pmcid":null,"publication_year":2000,"study_acronym_array":["SPLIT"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["130EBV Disease and Lymphoproliferative Disease (LPD) after a First Liver Transplant in Children Enrolled in the SPLIT Registry."]},{"_index":"publications_v001","_id":"JMLkapMBHb0XhPerUtkT","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"Longitudinal Assessment of Bariatric Surgery","author_array":["Wahed A","Patterson E","Smith MD","Courcoulas AP","Dakin G","Flum D","Machado L","Mitchell JE","Pender J","Pomp A","Pories WJ","Ramanathan RC","Schrope B","Ude A","Wolfe B"],"@version":"1","id":1942,"title":"30-day Mortality in the Longitudinal Assessment of Bariatric Surgery","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003ePatterson E, Smith MD, Courcoulas AP, Dakin G, Flum D, Machado L, Mitchell JE, Pender J, Pomp A, Pories WJ, Ramanathan RC, Schrope B, Ude A, Wolfe B, Wahed A. 30-day Mortality in the Longitudinal Assessment of Bariatric Surgery. \u003ci\u003eProceedings of International Federation for the Surgery of Obesity and Metabolic Disorders\u003c/i\u003e; September 2010; Los Angeles, CA. 2010 Sep.\u003c/span\u003e","author":"Wahed A, Patterson E, Smith MD, Courcoulas AP, Dakin G, Flum D, Machado L, Mitchell JE, Pender J, Pomp A, Pories WJ, Ramanathan RC, Schrope B, Ude A, Wolfe B","study_acronym":"LABS","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:43.026Z","study_name_array":["Longitudinal Assessment of Bariatric Surgery"],"pmcid":"","publication_year":2010,"study_acronym_array":["LABS"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["30-day Mortality in the Longitudinal Assessment of Bariatric Surgery"]},{"_index":"publications_v001","_id":"-_3kapMBC2xkvCSBUxTQ","_score":null,"_source":{"affiliation":"Department of Obstetrics and Gynecology, Loyola University Chicago, Stritch School of Medicine, Chicago, Illinois 60153, USA. L.Brubaker@lumc.edu","request_id_array":null,"doi":"10.1016/j.juro.2011.11.087","request_id":null,"study_name":"The Stress Incontinence Surgical Treatment Efficacy Trial","author_array":["Gormley EA","Urinary Incontinence Treatment Network","Xu Y","Brubaker L","Chai TC","Zyczynski HM","Albo M","Norton PA","Richter HE","Zimmern P","Kraus S","Sirls L","Kusek JW","Stoddard A","Tennstedt S"],"@version":"1","id":1673,"title":"5-year continence rates, satisfaction and adverse events of burch urethropexy and fascial sling surgery for urinary incontinence.","pmid":"22341290","publication_type":"Journal","citation":"\u003cspan\u003eBrubaker L, Richter HE, Norton PA, Albo M, Zyczynski HM, Chai TC, Zimmern P, Kraus S, Sirls L, Kusek JW, Stoddard A, Tennstedt S, Gormley EA, Urinary Incontinence Treatment Network. 5-year continence rates, satisfaction and adverse events of burch urethropexy and fascial sling surgery for urinary incontinence. \u003ci\u003eJ Urol\u003c/i\u003e 2012 Apr;187(4):1324-30. Epub 2012 Feb 15.\u003c/span\u003e","author":"Gormley EA, Urinary Incontinence Treatment Network, Xu Y, Brubaker L, Chai TC, Zyczynski HM, Albo M, Norton PA, Richter HE, Zimmern P, Kraus S, Sirls L, Kusek JW, Stoddard A, Tennstedt S","study_acronym":"SISTEr","study_type":"Interventional","abstract":"We characterized continence, satisfaction and adverse events in women at least 5 years after Burch urethropexy or fascial sling with longitudinal followup of randomized clinical trial participants.","@timestamp":"2024-11-26T23:52:42.965Z","study_name_array":["The Stress Incontinence Surgical Treatment Efficacy Trial"],"pmcid":"PMC3586411","publication_year":2012,"study_acronym_array":["SISTEr"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["5-year continence rates, satisfaction and adverse events of burch urethropexy and fascial sling surgery for urinary incontinence."]},{"_index":"publications_v001","_id":"d_3kapMBC2xkvCSBUBSl","_score":null,"_source":{"affiliation":"University of Alabama at Birmingham, Birmingham, Alabama for the Urinary Incontinence Treatment Network.","request_id_array":null,"doi":"10.1016/j.juro.2014.08.089","request_id":null,"study_name":"Trial Of Mid-Urethral Slings","author_array":["Rickey L","Richter HE","Chang RP","Litman HJ","Kusek JW","Sirls LT","Kraus SR","Wai C","Norton P","Albo M","Zyczynski H","Stoddard AM","Kenton K"],"@version":"1","id":1307,"title":"5-year longitudinal followup after retropubic and transobturator mid urethral slings.","pmid":"25158274","publication_type":"Journal","citation":"\u003cspan\u003eKenton K, Stoddard AM, Zyczynski H, Albo M, Rickey L, Norton P, Wai C, Kraus SR, Sirls LT, Kusek JW, Litman HJ, Chang RP, Richter HE. 5-year longitudinal followup after retropubic and transobturator mid urethral slings. \u003ci\u003eJ Urol\u003c/i\u003e 2015 Jan;193(1):203-10. Epub 2014 Aug 23.\u003c/span\u003e","author":"Rickey L, Richter HE, Chang RP, Litman HJ, Kusek JW, Sirls LT, Kraus SR, Wai C, Norton P, Albo M, Zyczynski H, Stoddard AM, Kenton K","study_acronym":"TOMUS","study_type":"Interventional","abstract":"Few studies have characterized longer-term outcomes after retropubic and transobturator mid urethral slings.","@timestamp":"2024-11-26T23:52:42.944Z","study_name_array":["Trial Of Mid-Urethral Slings"],"pmcid":"PMC4272663","publication_year":2015,"study_acronym_array":["TOMUS"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["5-year longitudinal followup after retropubic and transobturator mid urethral slings."]},{"_index":"publications_v001","_id":"JsLkapMBHb0XhPerWdr7","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"Longitudinal Assessment of Bariatric Surgery","author_array":["Belle SH","Wolfe BM","Ramanathan R","Pories W","Pomp A","Pender J","Oelschlager B","Mitchell J","Miles CM","Garcia L","Dellinger P","Courcoulas A","Inabnet WB","O’Rourke R","Wahed A","Bessler M"],"@version":"1","id":2121,"title":"A Comparison Of 30 Day Outcomes After Primary And Revisional Bariatric Surgical Procedures From The Longitudinal Assessment Of Bariatric Surgery (LABS) Study","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eInabnet WB, O’Rourke R, Wahed A, Bessler M, Courcoulas A, Dellinger P, Garcia L, Miles CM, Mitchell J, Oelschlager B, Pender J, Pomp A, Pories W, Ramanathan R, Wolfe BM, Belle SH. A Comparison Of 30 Day Outcomes After Primary And Revisional Bariatric Surgical Procedures From The Longitudinal Assessment Of Bariatric Surgery (LABS) Study. \u003ci\u003eProceedings of American Society for Metabolic and Bariatric Surgery\u003c/i\u003e; June 2009; Grapevine, TX. 2009 Jun.\u003c/span\u003e","author":"Belle SH, Wolfe BM, Ramanathan R, Pories W, Pomp A, Pender J, Oelschlager B, Mitchell J, Miles CM, Garcia L, Dellinger P, Courcoulas A, Inabnet WB, O’Rourke R, Wahed A, Bessler M","study_acronym":"LABS","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:43.038Z","study_name_array":["Longitudinal Assessment of Bariatric Surgery"],"pmcid":"","publication_year":2009,"study_acronym_array":["LABS"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A Comparison Of 30 Day Outcomes After Primary And Revisional Bariatric Surgical Procedures From The Longitudinal Assessment Of Bariatric Surgery (LABS) Study"]},{"_index":"publications_v001","_id":"V_3kapMBC2xkvCSBWBZR","_score":null,"_source":{"affiliation":"1 Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University,\nTheodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany\n2 Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University,\nTheodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany\n3 Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Gian Battista\nCamozzi 3, Ranica, BG, 24020, Italy","request_id_array":["22433"],"doi":"10.3390/app132413298","request_id":"22433","study_name":"Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease","author_array":["Caroli A","Strittmatter A","Zöllner FG"],"@version":"1","id":308,"title":"A Multistage Rigid-Affine-Deformable Network for\nThree-Dimensional Multimodal Medical Image Registration","pmid":null,"publication_type":"Journal","citation":null,"author":"Caroli A, Strittmatter A, Zöllner FG","study_acronym":"CRISP","study_type":"Observational","abstract":"Abstract: Multimodal image registration is an important component of medical image processing, allowing the integration of complementary information from various imaging modalities to improve clinical applications like diagnosis and treatment planning. We proposed a novel multistage neural network for three-dimensional multimodal medical image registration, which addresses the challenge of larger rigid deformations commonly present in medical images due to variations in patient positioning in different scanners and rigid anatomical structures. This multistage network combines rigid, affine and deformable transformations in three stages. The network was trained unsupervised with Mutual Information and Gradient L2 loss. We compared the results of our proposed multistage \nnetwork with a rigid-affine-deformable registration with the classical registration method NiftyReg as baseline and a multistage network, which combines affine and deformable transformation, as benchmark. To evaluate the performance of the proposed multistage network, we used four three- \ndimensional multimodal in-vivo datasets: Three renal MR datasets consisting of T1-weighted and \nT2-weighted MR scans and one liver dataset containing CT and T1-weighted MR scans. Experimental results showed that combining rigid, affine and deformable transformations in a multistage network leads to registration results with a high structural similarity, overlap of the corresponding structures (Dice: 76.7 ± 12.5, 61.1 ± 14.0, 64.8 ± 16.2, 68.1 ± 24.6 for the four datasets) and a low level of image folding (|J| ? 0: less than or equal to 1.1%), resulting in a medical plausible registration result.","@timestamp":"2024-11-26T23:52:43.098Z","study_name_array":["Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease"],"pmcid":null,"publication_year":2023,"study_acronym_array":["CRISP"],"publication_origin":"Secondary Research","study_type_array":["Observational"]},"sort":["A Multistage Rigid-Affine-Deformable Network for\nThree-Dimensional Multimodal Medical Image Registration"]},{"_index":"publications_v001","_id":"dMLkapMBHb0XhPerSddl","_score":null,"_source":{"affiliation":"Duke University Medical Center, Durham, North Carolina.","request_id_array":null,"doi":"10.1097/JU.0000000000000465","request_id":null,"study_name":"Symptoms of Lower Urinary Tract Dysfunction Phenotyping Study","author_array":["Cella D","Gillespie BW","Jelovsek JE","Flynn KE","Bradley CS","Kirkali Z","Smith AR","Griffith JW","LURN Study Group","Weinfurt KP","Talaty P","Helfand BT"],"@version":"1","id":1053,"title":"A New Brief Clinical Assessment of Lower Urinary Tract Symptoms for Women and Men: LURN SI-10.","pmid":"31364922","publication_type":"Journal","citation":"\u003cspan\u003eCella D, Smith AR, Griffith JW, Kirkali Z, Flynn KE, Bradley CS, Jelovsek JE, Gillespie BW, Helfand BT, Talaty P, Weinfurt KP, LURN Study Group. A New Brief Clinical Assessment of Lower Urinary Tract Symptoms for Women and Men: LURN SI-10. \u003ci\u003eJ Urol\u003c/i\u003e 2020 Jan;203(1):164-170. Epub 2019 Jul 31.\u003c/span\u003e","author":"Cella D, Gillespie BW, Jelovsek JE, Flynn KE, Bradley CS, Kirkali Z, Smith AR, Griffith JW, LURN Study Group, Weinfurt KP, Talaty P, Helfand BT","study_acronym":"LURN","study_type":"Observational","abstract":"Lower urinary tract symptoms are common in men and women. Members of the LURN (Lower Urinary Tract Dysfunction Research Network) sought to create a brief, clinically relevant tool to improve existing measurements of lower urinary tract symptoms in men and women.","@timestamp":"2024-11-26T23:52:42.893Z","study_name_array":["Symptoms of Lower Urinary Tract Dysfunction Phenotyping Study"],"pmcid":"PMC6904437","publication_year":2020,"study_acronym_array":["LURN"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A New Brief Clinical Assessment of Lower Urinary Tract Symptoms for Women and Men: LURN SI-10."]},{"_index":"publications_v001","_id":"pP3kapMBC2xkvCSBTBMz","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":null,"request_id":null,"study_name":null,"author_array":["Brunt EM","Abelmalek MF","Cardona D","McCall SJ","Unlap A","Belt P","Ferrell LD","Wilson L","Diehl AM","Guy CD","Suzuki A","Burchette JL"],"@version":"1","id":1860,"title":"A Novel Immunohiostochemical Staining Pattern for Keratin 8/18 Plus Ubiquitin in Nonalcoholic Fatty Liver Disease Is Associated with Increased Disease Severity and Advanced Fibrosis","pmid":null,"publication_type":"Journal","citation":"\u003cspan\u003eGuy CD , Suzuki A , Burchette JL , Brunt EM , Abelmalek MF , Cardona D , McCall SJ , Unlap A , Belt P , Wilson L , Ferrell LD , Diehl AM. A Novel Immunohiostochemical Staining Pattern for Keratin 8/18 Plus Ubiquitin in Nonalcoholic Fatty Liver Disease Is Associated with Increased Disease Severity and Advanced Fibrosis. \u003ci\u003eMod Pathol\u003c/i\u003e 2011 Feb;24(Supplement 1s):361A.\u003c/span\u003e","author":"Brunt EM, Abelmalek MF, Cardona D, McCall SJ, Unlap A, Belt P, Ferrell LD, Wilson L, Diehl AM, Guy CD, Suzuki A, Burchette JL","study_acronym":null,"study_type":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is a global health dilemma. The gold standard for diagnosis is liver biopsy. Ballooned hepatocytes (BH) are histologic manifestations of hepatocellular injury and are characteristic features of steatohepatitis (SH), the more severe and potentially more progressive form of NAFLD. Definitive histologic identification of BH on routine stains, however, can be difficult. Immunohistochemical (IHC) staining for loss of the normal hepatocytic keratin 8/18 (K8/18) can serve as an objective marker of BH. We sought to explore the utility of a K8/18 plus ubiquitin (Ub) double IHC stain for the histologic evaluation of adult NAFLD.","@timestamp":"2024-11-26T23:52:43.018Z","study_name_array":null,"pmcid":null,"publication_year":2011,"study_acronym_array":null,"publication_origin":"Contributing Study","study_type_array":null},"sort":["A Novel Immunohiostochemical Staining Pattern for Keratin 8/18 Plus Ubiquitin in Nonalcoholic Fatty Liver Disease Is Associated with Increased Disease Severity and Advanced Fibrosis"]},{"_index":"publications_v001","_id":"48LkapMBHb0XhPerT9gh","_score":null,"_source":{"affiliation":"1School of Public Health and Tropical Medicine Tulane University, 2 School of Medicine, Tulane University\n","request_id_array":["22982"],"doi":"10.1016/j.jval.2022.04.1637","request_id":"22982","study_name":"Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventions and Complications","author_array":["Lin Y","Shi L","Fonseca V","Tang T","Shao H"],"@version":"1","id":162,"title":"A Novel Risk Engine for Diabetes-related Complications among Individuals with Type 1 Diabetes","pmid":null,"publication_type":"Conference Presentation","citation":null,"author":"Lin Y, Shi L, Fonseca V, Tang T, Shao H","study_acronym":"DCCT/EDIC","study_type":"Interventional","abstract":"Type 1 diabetes (T1D) is often characterized by the destruction of insulin-producing pancreatic ?? cells1,\nEven though T1D affects people of all ages, the risk of developing T1D peaks for children that are aged from 5-7\nThe prevalence of T1D among people that are under 30 years old was 2.6/1000 at the time of 2010\nThe average increase rate for T1D during the period 1999-2010 was 0.08% per 4 years2\nAs evidenced by Diabetes Controls and Complications Trial (DCCT) and the following Epidemiology of Diabetes Interventions and Complications (EDIC) study3, compared to conventional therapy,\nIntensive T1D management approaches, which include using insulin injections/pump together with self-monitored glucose measurement to keep blood glucose within normal range, have long-term protection effect against the development and progression of T1D related complications4\nThere is an inverse relationship between the intensive T1D treatment and the incidence of severe hypoglycemia4\nT1D complications are a concern,\nT1D complications are the major cause of morbidity and mortality among T1D patients5\nCVD complications are the leading causes of death among T1D patients5\nUnderstanding and identifying risk factors of T1D complications is crucial to better T1D care management, which protects T1D patients against T1D complications,\nNo threshold effect: any decrease in the hemoglobin A1C (HbA1c) level is associated with a comparable decrease in the relative risk of complications4\nThere is also no specific HbA1c level that indicates the occurrence of T1D complications, which suggest the presence of other risk factors such as hypertension, smoking, and obesity4\nRisk engine for T1D complications,\nCurrently, there is no generally accepted risk-predicting model for the T1D population in the United States\n","@timestamp":"2024-11-26T23:52:43.101Z","study_name_array":["Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventions and Complications"],"pmcid":null,"publication_year":2022,"study_acronym_array":["DCCT/EDIC"],"publication_origin":"Secondary Research","study_type_array":["Interventional"]},"sort":["A Novel Risk Engine for Diabetes-related Complications among Individuals with Type 1 Diabetes"]},{"_index":"publications_v001","_id":"JP3kapMBC2xkvCSBShO_","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":"10.1002/hep.24666","request_id":null,"study_name":"Silymarin Trial for Hepatitis C and NASH","author_array":["Doo EC","Fried MW","Meyers CM","Reddy KR","The SYNCH Study Group","Navarro VJ","Belle SH","Wahed AS","Afdhal NH","Hawke RL"],"@version":"1","id":1745,"title":"A Randomized, Placebo-Controlled Trial of Oral Silymarin (Milk Thistle) For Chronic Hepatitis C: Final Results of the SYNCH Multicenter Study.","pmid":null,"publication_type":"Journal","citation":"\u003cspan\u003eFried MW, Navarro VJ, Afdhal NH, Belle SH, Wahed AS, Hawke RL, Doo EC, Meyers CM, Reddy KR, The SYNCH Study Group. A Randomized, Placebo-Controlled Trial of Oral Silymarin (Milk Thistle) For Chronic Hepatitis C: Final Results of the SYNCH Multicenter Study. \u003ci\u003eHepatology\u003c/i\u003e 2011 Oct;54(Suppl S1):475A.\u003c/span\u003e","author":"Doo EC, Fried MW, Meyers CM, Reddy KR, The SYNCH Study Group, Navarro VJ, Belle SH, Wahed AS, Afdhal NH, Hawke RL","study_acronym":"SyNCH","study_type":"Interventional","abstract":"The botanical extract silymarin, commonly known\r\nas milk thistle, is a polyphenolic flavonoid with anti-oxidant,\r\nanti-inflammatory, and immunomodulatory properties in vitro\r\nand is used extensively by patients with chronic liver disease.\r\nThis trial evaluated the effect of high doses of oral silymarin on\r\ndisease activity in patients with chronic hepatitis C.","@timestamp":"2024-11-26T23:52:43.014Z","study_name_array":["Silymarin Trial for Hepatitis C and NASH"],"pmcid":null,"publication_year":2011,"study_acronym_array":["SyNCH"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["A Randomized, Placebo-Controlled Trial of Oral Silymarin (Milk Thistle) For Chronic Hepatitis C: Final Results of the SYNCH Multicenter Study."]},{"_index":"publications_v001","_id":"5cLkapMBHb0XhPerWdn7","_score":null,"_source":{"affiliation":"University of California, Irvine, Irvine, California; Children's Hospital of Orange County, Orange, California. Electronic address: aekhoury@uci.edu.","request_id_array":["21155"],"doi":"10.1016/j.juro.2017.11.080","request_id":"21155","study_name":"Randomized Intervention for Children with Vesico Ureteral Reflux","author_array":["Wehbi E","Alam Y","Wang ZT","Khoury A"],"@version":"1","id":1068,"title":"A Reanalysis of the RIVUR Trial Using a Risk Classification System.","pmid":"29198997","publication_type":"Journal","citation":"\u003cspan\u003eWang ZT, Wehbi E, Alam Y, Khoury A. A Reanalysis of the RIVUR Trial Using a Risk Classification System. \u003ci\u003eJ Urol\u003c/i\u003e 2018 Jun;199(6):1608-1614. Epub 2017 Dec 2.\u003c/span\u003e","author":"Wehbi E, Alam Y, Wang ZT, Khoury A","study_acronym":"RIVUR","study_type":"Interventional","abstract":"The RIVUR (Randomized Intervention for Children with Vesicoureteral Reflux) trial showed a 50% decrease in the risk of urinary tract infection recurrence in children with reflux receiving continuous antibiotic prophylaxis. We reanalyzed the RIVUR data with the purpose of using a risk classification system to identify children who are more likely to benefit from continuous antibiotic prophylaxis.","@timestamp":"2024-11-26T23:52:42.890Z","study_name_array":["Randomized Intervention for Children with Vesico Ureteral Reflux"],"pmcid":null,"publication_year":2018,"study_acronym_array":["RIVUR"],"publication_origin":"Secondary Research","study_type_array":["Interventional"]},"sort":["A Reanalysis of the RIVUR Trial Using a Risk Classification System."]},{"_index":"publications_v001","_id":"6v3kapMBC2xkvCSBUxTQ","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"Longitudinal Assessment of Bariatric Surgery","author_array":["White GE","Devlin MJ","King WC","Kalarchian M","Marcus MD","Garcia L","Yanovski SZ","Mitchell JE"],"@version":"1","id":1138,"title":"A Three-Year Evaluation of Eating Pathology and Outcome in the LABS-3 Study","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eDevlin MJ, King WC, Kalarchian M, White GE, Marcus MD, Garcia L, Yanovski SZ, Mitchell JE. A Three-Year Evaluation of Eating Pathology and Outcome in the LABS-3 Study. \u003ci\u003eProceedings of 32nd Annual Meeting of the American Society for Metabolic and Bariatric Surgery\u003c/i\u003e; November 2015; Los Angeles, California. 2015 Nov.\u003c/span\u003e","author":"White GE, Devlin MJ, King WC, Kalarchian M, Marcus MD, Garcia L, Yanovski SZ, Mitchell JE","study_acronym":"LABS","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:42.906Z","study_name_array":["Longitudinal Assessment of Bariatric Surgery"],"pmcid":"","publication_year":2015,"study_acronym_array":["LABS"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A Three-Year Evaluation of Eating Pathology and Outcome in the LABS-3 Study"]},{"_index":"publications_v001","_id":"Cv3kapMBC2xkvCSBShO_","_score":null,"_source":{"affiliation":"2 Sax Institute, Sydney, NSW, Australia.","request_id_array":["20517"],"doi":"10.1177/0962280217698174","request_id":"20517","study_name":null,"author_array":["Barr M","Clark RG"],"@version":"1","id":1084,"title":"A blended link approach to relative risk regression.","pmid":"29298596","publication_type":"Journal","citation":"\u003cspan\u003eClark RG, Barr M. A blended link approach to relative risk regression. \u003ci\u003eStat Methods Med Res\u003c/i\u003e 2018 Nov;27(11):3325-3339. Epub 2017 Mar 13.\u003c/span\u003e","author":"Barr M, Clark RG","study_acronym":null,"study_type":null,"abstract":"A binary health outcome may be regressed on covariates using a log link, rather than more typical link functions such as the logit. This allows the exponentiated regression coefficient for each covariate to be interpreted as a relative risk conditional on the remaining covariates. Relative risks are simpler to interpret than the odds ratios which arise with a logit link. There are practical and conceptual challenges in log-link binary regression, mainly due to the requirement that probabilities are less than or equal to 1. Viable probabilities are now usually achieved by the imposition of a constraint on the parameter space, but the log link function is still more work to apply in practice. We propose instead a new smooth link function which is equal to the log up to a cutoff and a linearly scaled logit function above the cutoff. The new approach is conceptually clearer, simpler to implement and generally less biased, and it retains the relative risk interpretation for all but the highest risk individuals. Alternative binary regressions are compared using a simulation study and a diabetic retinopathy dataset.","@timestamp":"2024-11-26T23:52:42.973Z","study_name_array":null,"pmcid":null,"publication_year":2018,"study_acronym_array":null,"publication_origin":"Secondary Research","study_type_array":null},"sort":["A blended link approach to relative risk regression."]},{"_index":"publications_v001","_id":"gsLkapMBHb0XhPerT9gg","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":null,"request_id":null,"study_name":null,"author_array":["Clement K","Kotronen A","Yki-Jarvinen H","Chalasani N","Kleiner DE","Rotter J","Burt A","Ratziu V","Anstee QM","Darlay R","Aithal G","Cordell HJ","Van Gaal L","Leathart J","Liu Y-L","Tordjman J","Valenti L","Day CP","Daly AK","Stickel F","Alison M","Romero-Gomez M","Andrade R","Reeves H","Bedossa P","Pihlajamaki J"],"@version":"1","id":1515,"title":"A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised nonalcoholic fatty liver disease","pmid":null,"publication_type":"Journal","citation":"\u003cspan\u003eAnstee QM, Darlay R, Leathart J, Liu Y-L , Tordjman J, Clement K, Aithal G, Valenti L, Van Gaal L, Stickel F, Alison M, Romero-Gomez M, Andrade R, Reeves H, Bedossa P, Pihlajamaki J, Kotronen A, Yki-Jarvinen H, Chalasani N, Kleiner DE, Rotter J, Burt A, Ratziu V, Cordell HJ, Daly AK, Day CP. A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised nonalcoholic fatty liver disease. \u003ci\u003eJ Hepatol\u003c/i\u003e 2013 Apr;58(Supplement 1):S46.\u003c/span\u003e","author":"Clement K, Kotronen A, Yki-Jarvinen H, Chalasani N, Kleiner DE, Rotter J, Burt A, Ratziu V, Anstee QM, Darlay R, Aithal G, Cordell HJ, Van Gaal L, Leathart J, Liu Y-L, Tordjman J, Valenti L, Day CP, Daly AK, Stickel F, Alison M, Romero-Gomez M, Andrade R, Reeves H, Bedossa P, Pihlajamaki J","study_acronym":null,"study_type":null,"abstract":"Inter-patient genetic variation and environment determine severity and progression of non-alcoholic fatty liver disease (NAFLD). Previous genome-wide association studies (GWAS) have provided important insights into modifier genes influencing\r\nradiologically determined steatosis (Romeo, 2008; Speliotes, 2011) and clinical biochemistry (Chambers, 2011) but have been unable to assess effect on steatohepatitis and fibrosis. Using data drawn form a large GWAS study of patients with histologically characterised NAFLD, we adopted a candidate-gene approach to re-examine the broader validity of these associations.","@timestamp":"2024-11-26T23:52:42.966Z","study_name_array":null,"pmcid":null,"publication_year":2013,"study_acronym_array":null,"publication_origin":"Contributing Study","study_type_array":null},"sort":["A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised nonalcoholic fatty liver disease"]},{"_index":"publications_v001","_id":"w_3kapMBC2xkvCSBVRUt","_score":null,"_source":{"affiliation":"Temple University School of Medicine, Philadelphia, PA 19140, USA. Pontarm@tuhs.temple.edu","request_id_array":null,"doi":"10.1111/j.1464-410X.2005.05684.x","request_id":null,"study_name":null,"author_array":["O'leary MP","Kusek JW","Landis JR","Knauss J","Litwin MS","CPCRN Study Group","Calhoun EA","Jang T","Pontari MA","McNaughton-Collins M"],"@version":"1","id":2586,"title":"A case-control study of risk factors in men with chronic pelvic pain syndrome.","pmid":"16104910","publication_type":"Journal","citation":"\u003cspan\u003ePontari MA, McNaughton-Collins M, O'leary MP, Calhoun EA, Jang T, Kusek JW, Landis JR, Knauss J, Litwin MS, CPCRN Study Group. A case-control study of risk factors in men with chronic pelvic pain syndrome. \u003ci\u003eBJU Int\u003c/i\u003e 2005 Sep;96(4):559-65.\u003c/span\u003e","author":"O'leary MP, Kusek JW, Landis JR, Knauss J, Litwin MS, CPCRN Study Group, Calhoun EA, Jang T, Pontari MA, McNaughton-Collins M","study_acronym":null,"study_type":null,"abstract":"To compare the demographic, behavioural, clinical and medical history characteristics of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and asymptomatic controls, to identify characteristics that might be associated with this syndrome.","@timestamp":"2024-11-26T23:52:43.074Z","study_name_array":null,"pmcid":"","publication_year":2005,"study_acronym_array":null,"publication_origin":"Contributing Study","study_type_array":null},"sort":["A case-control study of risk factors in men with chronic pelvic pain syndrome."]},{"_index":"publications_v001","_id":"EsLkapMBHb0XhPerUtkT","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":"10.1056/NEJMoa1109333","request_id":null,"study_name":"Treatment Options for Type 2 Diabetes in Adolescents \u0026 Youth","author_array":["Levitt Katz L","Yasuda P","Xu YK","Wexler K","Ward A","Ortiz R","Muñoz C","Miller D","Mansilla V","Law E","Kaufman F","Hollen B","Hernandez S","Fleury-Milfort E","Fisher L","Estrada S","Dreimane D","Conrad B","Chang N","Barraza V","Geffner M","Rogers D","Narasimhan S","McGuigan P","MacLeish S","Koontz M","Kaminski B","Ievers-Landis C","Haider A","Davis A","Dahms W","Casey T","Abrams E","Cuttler L","Zarate M","Thamotharan S","Schreiner B","McGirk S","Kamath N","Jones SM","Haymond M","Gunn S","Bush C","Anderson B","McKay S","Kaufman F","Wilfley D","Tollefsen S","Nathan DM","Cuttler L","Arslanian S","Copeland K","Linder B","Pyle L","Hirst K","Libman I","Kriska A","Hannon T","Galvin B","Foster S","Bacha F","Arslanian S","Willi S","Schwartzman B","McKnight H","McGinley G","Lipman T","Lassiter C","Keating C","Kaplan J","Johnson B","Boyd S","Berkowitz R","Robbins K","Seidman D","Siegel-Czarkowski L","Speiser P","Laffel L","Goebel-Fabbri A","Hall M","Higgins L","Keady J","Malloy M","Milaszewski K","Orkin L","Nathan DM","Angelescu A","Bissett L","Ciccarelli C","Delahanty L","Goldman V","Hardy O","Larkin M","Levitsky L","McEachern R","Norman D","Nwosu D","Park-Bennett S","Richards D","Sherry N","Steiner B","Tollefsen S","Carnes S","Dempsher D","Flomo D","Kociela V","Whelan T","Wolff B","Weinstock R","Bowerman D","Bristol S","Bulger J","Hartsig J","Izquierdo R","Kearns J","Saletsky R","Trief P","Zeitler P","Abramson N","Bradhurst A","Celona-Jacobs N","Downey M","Higgins J","Kelsey M","Klingensmith G","Nadeau K","Witten T","Copeland K","Boss E","Brown R","Chadwick J","Chalmers L","Chernausek S","Hebensperger A","Macha C","Newgent R","Nordyke A","Olson D","Poulsen T","Pratt L","Preske J","Schanuel J","Sternlof S","Lynch J","Amodei N","Barajas R","Cody C","Hale D","Hernandez J","Ibarra C","Morales E","Rivera S","Rupert G","Wauters A","White N","Arbeláez A","Flomo D","Jones J","Jones T","Sadler M","Tanner M","Timpson A","Welch R","Caprio S","Grey M","Guandalini C","Lavietes S","Rose P","Syme A","Tamborlane W","Hirst K","Edelstein S","Feit P","Grover N","Long C","Pyle L","Linder B","Marcovina SM","Harting J","Shepherd J","Fan B","Marquez L","Sherman M","Wang J","Nichols M","Mayer-Davis E","Liu Y","Lima J","Gidding S","Puccella J","Ricketts E","Danis R","Domalpally A","Goulding A","Neill S","Vargo P","Wilfley D","Aldrich-Rasche D","Franklin K","Massmann C","O'Brien D","Patterson J","Tibbs T","Van Buren D","Palmert M","Ratner R","Dremaine D","Silverstein J","Holden H","TODAY Study Group","Zeitler P","Pellizzari M","Ovalles M","Ng D","Motaghedi R","Leibel N","Kringas P","Gallagher D","Fennoy I","Cain R","Goland R","Venditti E","Songer T","Porter K","Marcus M"],"@version":"1","id":1651,"title":"A clinical trial to maintain glycemic control in youth with type 2 diabetes.","pmid":"22540912","publication_type":"Journal","citation":"\u003cspan\u003eTODAY Study Group, Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F. A clinical trial to maintain glycemic control in youth with type 2 diabetes. \u003ci\u003eN Engl J Med\u003c/i\u003e 2012 Jun 14;366(24):2247-56. Epub 2012 Apr 29.\u003c/span\u003e","author":"Levitt Katz L, Yasuda P, Xu YK, Wexler K, Ward A, Ortiz R, Muñoz C, Miller D, Mansilla V, Law E, Kaufman F, Hollen B, Hernandez S, Fleury-Milfort E, Fisher L, Estrada S, Dreimane D, Conrad B, Chang N, Barraza V, Geffner M, Rogers D, Narasimhan S, McGuigan P, MacLeish S, Koontz M, Kaminski B, Ievers-Landis C, Haider A, Davis A, Dahms W, Casey T, Abrams E, Cuttler L, Zarate M, Thamotharan S, Schreiner B, McGirk S, Kamath N, Jones SM, Haymond M, Gunn S, Bush C, Anderson B, McKay S, Kaufman F, Wilfley D, Tollefsen S, Nathan DM, Cuttler L, Arslanian S, Copeland K, Linder B, Pyle L, Hirst K, Libman I, Kriska A, Hannon T, Galvin B, Foster S, Bacha F, Arslanian S, Willi S, Schwartzman B, McKnight H, McGinley G, Lipman T, Lassiter C, Keating C, Kaplan J, Johnson B, Boyd S, Berkowitz R, Robbins K, Seidman D, Siegel-Czarkowski L, Speiser P, Laffel L, Goebel-Fabbri A, Hall M, Higgins L, Keady J, Malloy M, Milaszewski K, Orkin L, Nathan DM, Angelescu A, Bissett L, Ciccarelli C, Delahanty L, Goldman V, Hardy O, Larkin M, Levitsky L, McEachern R, Norman D, Nwosu D, Park-Bennett S, Richards D, Sherry N, Steiner B, Tollefsen S, Carnes S, Dempsher D, Flomo D, Kociela V, Whelan T, Wolff B, Weinstock R, Bowerman D, Bristol S, Bulger J, Hartsig J, Izquierdo R, Kearns J, Saletsky R, Trief P, Zeitler P, Abramson N, Bradhurst A, Celona-Jacobs N, Downey M, Higgins J, Kelsey M, Klingensmith G, Nadeau K, Witten T, Copeland K, Boss E, Brown R, Chadwick J, Chalmers L, Chernausek S, Hebensperger A, Macha C, Newgent R, Nordyke A, Olson D, Poulsen T, Pratt L, Preske J, Schanuel J, Sternlof S, Lynch J, Amodei N, Barajas R, Cody C, Hale D, Hernandez J, Ibarra C, Morales E, Rivera S, Rupert G, Wauters A, White N, Arbeláez A, Flomo D, Jones J, Jones T, Sadler M, Tanner M, Timpson A, Welch R, Caprio S, Grey M, Guandalini C, Lavietes S, Rose P, Syme A, Tamborlane W, Hirst K, Edelstein S, Feit P, Grover N, Long C, Pyle L, Linder B, Marcovina SM, Harting J, Shepherd J, Fan B, Marquez L, Sherman M, Wang J, Nichols M, Mayer-Davis E, Liu Y, Lima J, Gidding S, Puccella J, Ricketts E, Danis R, Domalpally A, Goulding A, Neill S, Vargo P, Wilfley D, Aldrich-Rasche D, Franklin K, Massmann C, O'Brien D, Patterson J, Tibbs T, Van Buren D, Palmert M, Ratner R, Dremaine D, Silverstein J, Holden H, TODAY Study Group, Zeitler P, Pellizzari M, Ovalles M, Ng D, Motaghedi R, Leibel N, Kringas P, Gallagher D, Fennoy I, Cain R, Goland R, Venditti E, Songer T, Porter K, Marcus M","study_acronym":"TODAY","study_type":"Interventional","abstract":"Despite the increasing prevalence of type 2 diabetes in youth, there are few data to guide treatment. We compared the efficacy of three treatment regimens to achieve durable glycemic control in children and adolescents with recent-onset type 2 diabetes.","@timestamp":"2024-11-26T23:52:43.002Z","study_name_array":["Treatment Options for Type 2 Diabetes in Adolescents \u0026 Youth"],"pmcid":"PMC3478667","publication_year":2012,"study_acronym_array":["TODAY"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["A clinical trial to maintain glycemic control in youth with type 2 diabetes."]},{"_index":"publications_v001","_id":"wv3kapMBC2xkvCSBVRUt","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":null,"request_id":null,"study_name":"Adult Living Donor Liver Transplantation Studies","author_array":["A2ALL Study Group","Kulik LM","Freise CE","Lok AS","Stravitz RT","Hulbert-Shearon TE","Fisher RA"],"@version":"1","id":2572,"title":"A comparison of adult living donor (LDLT) to deceased donor liver transplant (DDLT) for hepatocellular carcinoma (HCC): data from the A2ALL study","pmid":null,"publication_type":"Journal","citation":"\u003cspan\u003eKulik LM, Freise CE, Lok AS, Stravitz RT, Hulbert-Shearon TE, Fisher RA, A2ALL Study Group. A comparison of adult living donor (LDLT) to deceased donor liver transplant (DDLT) for hepatocellular carcinoma (HCC): data from the A2ALL study. \u003ci\u003eHepatology\u003c/i\u003e 2005 Oct 5;42(Suppl S1):199A.\u003c/span\u003e","author":"A2ALL Study Group, Kulik LM, Freise CE, Lok AS, Stravitz RT, Hulbert-Shearon TE, Fisher RA","study_acronym":"A2ALL","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:43.073Z","study_name_array":["Adult Living Donor Liver Transplantation Studies"],"pmcid":null,"publication_year":2005,"study_acronym_array":["A2ALL"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A comparison of adult living donor (LDLT) to deceased donor liver transplant (DDLT) for hepatocellular carcinoma (HCC): data from the A2ALL study"]},{"_index":"publications_v001","_id":"08LkapMBHb0XhPerSddo","_score":null,"_source":{"affiliation":"Nephrology Clinical Trials Center, Vanderbilt University Medical Center, 1211 21st Avenue South, 215 Medical Arts Building, Nashville, TN 37232-1371, USA. julia.lewis@vanderbilt.edu","request_id_array":null,"doi":"10.1097/01.ASN.0000146688.74084.A3","request_id":null,"study_name":null,"author_array":["Douglas J","Greene T","Contreras G","AASK Study Group","Wright JT Jr","Wang X","Lewis J","Appel L","Van Lente F","Toto R","Lash J"],"@version":"1","id":2632,"title":"A comparison of iothalamate-GFR and serum creatinine-based outcomes: acceleration in the rate of GFR decline in the African American Study of Kidney Disease and Hypertension.","pmid":"15579521","publication_type":"Journal","citation":"\u003cspan\u003eLewis J, Greene T, Appel L, Contreras G, Douglas J, Lash J, Toto R, Van Lente F, Wang X, Wright JT Jr, AASK Study Group. A comparison of iothalamate-GFR and serum creatinine-based outcomes: acceleration in the rate of GFR decline in the African American Study of Kidney Disease and Hypertension. \u003ci\u003eJ Am Soc Nephrol\u003c/i\u003e 2004 Dec;15(12):3175-83.\u003c/span\u003e","author":"Douglas J, Greene T, Contreras G, AASK Study Group, Wright JT Jr, Wang X, Lewis J, Appel L, Van Lente F, Toto R, Lash J","study_acronym":null,"study_type":null,"abstract":"In renal clinical trials, both slope-based and time-to-event renal outcomes have been used. These outcomes are typically based on estimates of GFR obtained using creatinine or iothalamate GFR (iGFR). The African American Study of Kidney Disease and Hypertension (AASK) was a trial in 1094 African Americans with hypertensive nephrosclerosis, which examined the effects of two levels of BP control and three antihypertensive regimens. This study compared the effects of the AASK interventions on outcomes based on serum creatinine with corresponding outcomes based on iGFR using 9742 matched pairs of iGFR and serum creatinine measurements. The iGFR-based outcomes included (1) a time-to-event composite outcome including a 50% GFR decline, ESRD, or death; (2) a composite outcome including a 50% GFR decline or ESRD; (3) mean decline in GFR in the first 3 mo after randomization (acute slope); (4) mean decline in GFR starting 3 mo after randomization (chronic slope); and (5) mean decline in GFR from baseline (total slope). The corresponding creatinine-based outcomes were (1) a composite of doubling of serum creatinine, ESRD, or death and (2) a composite of doubling of serum creatinine or ESRD and acute, chronic, and total slopes defined by the mean change in estimated GFR (eGFR), where eGFR was estimated from a regression equation for GFR depending primarily on serum creatinine and developed in AASK enrollees. Mean changes in iGFR and eGFR were also compared under extended models that allowed for the possibility that the rate of GFR decline may change over time during the chronic phase. an apparent acceleration in rate of decline of renal function over time was found. Subtle differences were observed between effects of the interventions on some of the creatinine and iGFR slope-based outcomes, but the main conclusions of the trial were similar for the serum creatinine and iothalamate-based measurements. This has important implications for the design of clinical trials with renal outcomes.","@timestamp":"2024-11-26T23:52:43.076Z","study_name_array":null,"pmcid":null,"publication_year":2004,"study_acronym_array":null,"publication_origin":"Contributing Study","study_type_array":null},"sort":["A comparison of iothalamate-GFR and serum creatinine-based outcomes: acceleration in the rate of GFR decline in the African American Study of Kidney Disease and Hypertension."]},{"_index":"publications_v001","_id":"Gf3kapMBC2xkvCSBWBZR","_score":null,"_source":{"affiliation":"Division of Endocrinology, University of Miami, Miami, FL, USA. jsosenko@med.miami.edu","request_id_array":null,"doi":"10.1111/j.1399-5448.2010.00662.x","request_id":null,"study_name":"Diabetes Prevention Trial of Type 1 Diabetes","author_array":["Krischer JP","Krause-Steinrauf H","Lachin JM","Diabetes Prevention Trial-Type 1 and TrialNet Study Groups","Mahon J","Sosenko JM","Rafkin L","Skyler JS","Greenbaum CJ","Thompson C","Palmer JP","Cuthbertson D"],"@version":"1","id":1849,"title":"A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants.","pmid":"20522170","publication_type":"Journal","citation":"\u003cspan\u003eSosenko JM, Mahon J, Rafkin L, Lachin JM, Krause-Steinrauf H, Krischer JP, Cuthbertson D, Palmer JP, Thompson C, Greenbaum CJ, Skyler JS, Diabetes Prevention Trial-Type 1 and TrialNet Study Groups. A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants. \u003ci\u003ePediatr Diabetes\u003c/i\u003e 2011 Mar;12(2):85-90.\u003c/span\u003e","author":"Krischer JP, Krause-Steinrauf H, Lachin JM, Diabetes Prevention Trial-Type 1 and TrialNet Study Groups, Mahon J, Sosenko JM, Rafkin L, Skyler JS, Greenbaum CJ, Thompson C, Palmer JP, Cuthbertson D","study_acronym":"DPT-1","study_type":"Interventional","abstract":"We assessed whether differing autoantibody screening criteria for type 1 diabetes (T1D) prevention trials result in different baseline metabolic profiles of those who screen positive.","@timestamp":"2024-11-26T23:52:43.022Z","study_name_array":["Diabetes Prevention Trial of Type 1 Diabetes"],"pmcid":"PMC2955175","publication_year":2011,"study_acronym_array":["DPT-1"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants."]},{"_index":"publications_v001","_id":"XsLkapMBHb0XhPerTdiJ","_score":null,"_source":{"affiliation":"Diabetes Control and Complications Trial Research Group, Bethesda, Md.","request_id_array":null,"doi":"","request_id":null,"study_name":"Diabetes Control and Complications Trial","author_array":["Klein R","Moss S"],"@version":"1","id":3118,"title":"A comparison of the study populations in the Diabetes Control and Complications Trial and the Wisconsin Epidemiologic Study of Diabetic Retinopathy.","pmid":"7695463","publication_type":"Journal","citation":"\u003cspan\u003eKlein R, Moss S. A comparison of the study populations in the Diabetes Control and Complications Trial and the Wisconsin Epidemiologic Study of Diabetic Retinopathy. \u003ci\u003eArch Intern Med\u003c/i\u003e 1995 Apr 10;155(7):745-54.\u003c/span\u003e","author":"Klein R, Moss S","study_acronym":"DCCT","study_type":"","abstract":"We compared the Diabetes Control and Complications Trial (DCCT) cohort with patients who had insulin-dependent diabetes mellitus (IDDM) in the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) to determine whether the DCCT cohort was similar to the patients with IDDM in the general population and whether the DCCT results are generalizable to a nonresearch population.","@timestamp":"2024-11-26T23:52:43.091Z","study_name_array":["Diabetes Control and Complications Trial"],"pmcid":"","publication_year":1995,"study_acronym_array":["DCCT"],"publication_origin":"Contributing Study","study_type_array":[null]},"sort":["A comparison of the study populations in the Diabetes Control and Complications Trial and the Wisconsin Epidemiologic Study of Diabetic Retinopathy."]},{"_index":"publications_v001","_id":"28LkapMBHb0XhPerT9gh","_score":null,"_source":{"affiliation":"Department of Medicine, University of California, San Francisco 94143, USA.","request_id_array":null,"doi":"10.1097/00007890-199704270-00005","request_id":null,"study_name":null,"author_array":["Lake JR","Wiesner RH","Zetterman RK","Somberg KA","Lombardero MS","Lawlor SM","Ascher NL"],"@version":"1","id":3049,"title":"A controlled analysis of the transjugular intrahepatic portosystemic shunt in liver transplant recipients. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Liver Transplantation Database.","pmid":"9133467","publication_type":"Journal","citation":"\u003cspan\u003eSomberg KA, Lombardero MS, Lawlor SM, Ascher NL, Lake JR, Wiesner RH, Zetterman RK. A controlled analysis of the transjugular intrahepatic portosystemic shunt in liver transplant recipients. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Liver Transplantation Database. \u003ci\u003eTransplantation\u003c/i\u003e 1997 Apr 27;63(8):1074-9.\u003c/span\u003e","author":"Lake JR, Wiesner RH, Zetterman RK, Somberg KA, Lombardero MS, Lawlor SM, Ascher NL","study_acronym":null,"study_type":null,"abstract":"The transjugular intrahepatic portosystemic shunt (TIPS) is an important treatment for complications of portal hypertension. As some authors have suggested that TIPS may facilitate liver transplantation technically, the objective of this study was to determine the impact of TIPS on the liver transplant operation and its outcome.","@timestamp":"2024-11-26T23:52:43.090Z","study_name_array":null,"pmcid":"","publication_year":1997,"study_acronym_array":null,"publication_origin":"Contributing Study","study_type_array":null},"sort":["A controlled analysis of the transjugular intrahepatic portosystemic shunt in liver transplant recipients. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Liver Transplantation Database."]},{"_index":"publications_v001","_id":"QsLkapMBHb0XhPerUtkT","_score":null,"_source":{"affiliation":"Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C-Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA.","request_id_array":null,"doi":"10.1126/science.1135245","request_id":null,"study_name":"Inflammatory Bowel Disease Genetics","author_array":["Griffiths A","Yang H","Duerr RH","Taylor KD","Brant SR","Rioux JD","Silverberg MS","Daly MJ","Steinhart AH","Abraham C","Regueiro M","Dassopoulos T","Bitton A","Targan S","Datta LW","Kistner EO","Cho JH","Nicolae DL","Rotter JI","Barmada MM","Gregersen PK","Lee AT","Schumm LP"],"@version":"1","id":2479,"title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.","pmid":"17068223","publication_type":"Journal","citation":"\u003cspan\u003eDuerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. \u003ci\u003eScience\u003c/i\u003e 2006 Dec 1;314(5804):1461-3. Epub 2006 Oct 26.\u003c/span\u003e","author":"Griffiths A, Yang H, Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Dassopoulos T, Bitton A, Targan S, Datta LW, Kistner EO, Cho JH, Nicolae DL, Rotter JI, Barmada MM, Gregersen PK, Lee AT, Schumm LP","study_acronym":"IBD","study_type":"Observational","abstract":"The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify genetic factors that might contribute to these disorders, we performed a genome-wide association study. We found a highly significant association between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23. An uncommon coding variant (rs11209026, c.1142G\u0026gt;A, p.Arg381Gln) confers strong protection against Crohn's disease, and additional noncoding IL23R variants are independently associated. Replication studies confirmed IL23R associations in independent cohorts of patients with Crohn's disease or ulcerative colitis. These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.","@timestamp":"2024-11-26T23:52:43.067Z","study_name_array":["Inflammatory Bowel Disease Genetics"],"pmcid":"PMC4410764","publication_year":2006,"study_acronym_array":["IBD"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A genome-wide association study identifies IL23R as an inflammatory bowel disease gene."]},{"_index":"publications_v001","_id":"-8LkapMBHb0XhPerTdeI","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis","author_array":["Spinner NB","Loomes KM","Hankenson KD","Tsai EA","Grochowski C","Falsey A","Kamath BM","Lin H","Underkoffler LA","Devoto M"],"@version":"1","id":1267,"title":"A genome-wide association study identifies THBS2 as a candidate modifier of liver disease severity in Alagille syndrome","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eLoomes KM, Tsai EA, Underkoffler LA, Grochowski C, Falsey A, Kamath BM, Lin H, Hankenson KD, Devoto M, Spinner NB. A genome-wide association study identifies THBS2 as a candidate modifier of liver disease severity in Alagille syndrome. \u003ci\u003eProceedings of American Association for the Study of Liver Diseases (AASLD) 65th Annual Meeting\u003c/i\u003e; November 10, 2014; Boston, MA. 2014 Nov. p. 252A.\u003c/span\u003e","author":"Spinner NB, Loomes KM, Hankenson KD, Tsai EA, Grochowski C, Falsey A, Kamath BM, Lin H, Underkoffler LA, Devoto M","study_acronym":"PROBE","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:42.934Z","study_name_array":["A Prospective Database of Infants With Cholestasis"],"pmcid":"","publication_year":2014,"study_acronym_array":["PROBE"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A genome-wide association study identifies THBS2 as a candidate modifier of liver disease severity in Alagille syndrome"]},{"_index":"publications_v001","_id":"scLkapMBHb0XhPerSddm","_score":null,"_source":{"affiliation":"Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada. andrew.paterson@utoronto.ca","request_id_array":null,"doi":"10.2337/db09-0653","request_id":null,"study_name":"Diabetes Control and Complications Trial","author_array":["Waggott D","Wong I","Sylvestre MP","Shen E","Hosseini SM","Boright AP","Paterson AD","Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group","Bull SB","Sun L","Canty AJ","Cox NJ","Nicolae D","Below JE","MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium)","Lachin JM","Cleary PA","Bharaj B"],"@version":"1","id":2059,"title":"A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.","pmid":"19875614","publication_type":"Journal","citation":"\u003cspan\u003ePaterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, Wong I, Bharaj B, Cleary PA, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Below JE, Nicolae D, Cox NJ, Canty AJ, Sun L, Bull SB, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. \u003ci\u003eDiabetes\u003c/i\u003e 2010 Feb;59(2):539-49. Epub 2009 Oct 29.\u003c/span\u003e","author":"Waggott D, Wong I, Sylvestre MP, Shen E, Hosseini SM, Boright AP, Paterson AD, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group, Bull SB, Sun L, Canty AJ, Cox NJ, Nicolae D, Below JE, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Lachin JM, Cleary PA, Bharaj B","study_acronym":"DCCT","study_type":"","abstract":"Glycemia is a major risk factor for the development of long-term complications in type 1 diabetes; however, no specific genetic loci have been identified for glycemic control in individuals with type 1 diabetes. To identify such loci in type 1 diabetes, we analyzed longitudinal repeated measures of A1C from the Diabetes Control and Complications Trial.","@timestamp":"2024-11-26T23:52:43.034Z","study_name_array":["Diabetes Control and Complications Trial"],"pmcid":"PMC2809960","publication_year":2010,"study_acronym_array":["DCCT"],"publication_origin":"Contributing Study","study_type_array":[null]},"sort":["A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose."]},{"_index":"publications_v001","_id":"tP3kapMBC2xkvCSBWxbg","_score":null,"_source":{"affiliation":"Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.","request_id_array":null,"doi":"10.1126/science.1142382","request_id":null,"study_name":"The Finland-United States Investigation of NIDDM Genetics Study","author_array":["Buchanan TA","Goldstein JL","Bark CW","Barnhart MW","Hetrick KN","White PP","Tong M","Sprau AG","Riebow NL","Conneely KN","Li XY","Xiao R","Pruim R","Hu T","Narisu N","Swift AJ","Ding CJ","Li Y","Duren WL","Erdos MR","Stringham HM","Chines PS","Jackson AU","Prokunina-Olsson L","Scott LJ","Mohlke KL","Bonnycastle LL","Boehnke M","Collins FS","Willer CJ","Tuomilehto J","Saramies J","Bergman RN","Doheny KF","Pugh EW","Abecasis GR","Kinnunen L","Valle TT","Watanabe RM","Xiang F","Watkins L"],"@version":"1","id":2432,"title":"A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.","pmid":"17463248","publication_type":"Journal","citation":"\u003cspan\u003eScott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. \u003ci\u003eScience\u003c/i\u003e 2007 Jun 1;316(5829):1341-5. Epub 2007 Apr 26.\u003c/span\u003e","author":"Buchanan TA, Goldstein JL, Bark CW, Barnhart MW, Hetrick KN, White PP, Tong M, Sprau AG, Riebow NL, Conneely KN, Li XY, Xiao R, Pruim R, Hu T, Narisu N, Swift AJ, Ding CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Scott LJ, Mohlke KL, Bonnycastle LL, Boehnke M, Collins FS, Willer CJ, Tuomilehto J, Saramies J, Bergman RN, Doheny KF, Pugh EW, Abecasis GR, Kinnunen L, Valle TT, Watanabe RM, Xiang F, Watkins L","study_acronym":"FUSION","study_type":"","abstract":"Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with \u0026gt;315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional \u0026gt;2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10.","@timestamp":"2024-11-26T23:52:43.064Z","study_name_array":["The Finland-United States Investigation of NIDDM Genetics Study"],"pmcid":"PMC3214617","publication_year":2007,"study_acronym_array":["FUSION"],"publication_origin":"Contributing Study","study_type_array":[null]},"sort":["A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants."]},{"_index":"publications_v001","_id":"EP3kapMBC2xkvCSBShO_","_score":null,"_source":{"affiliation":"The Center for Applied Genomics, The Children's Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America.","request_id_array":null,"doi":"10.1371/journal.pgen.1002293","request_id":null,"study_name":"Type 1 Diabetes Genetics Consortium","author_array":["Monos DS","Bakay M","Hakonarson H","Polychronakos C","Grant SF","Sleiman PM","Kim CE","Bradfield JP","Mentch FD","Qiu H","Glessner JT","Thomas KA","Frackelton EC","Chiavacci RM","Imielinski M","Qu HQ","Wang K","Zhang H","Pandey R"],"@version":"1","id":1757,"title":"A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.","pmid":"21980299","publication_type":"Journal","citation":"\u003cspan\u003eBradfield JP, Qu HQ, Wang K, Zhang H, Sleiman PM, Kim CE, Mentch FD, Qiu H, Glessner JT, Thomas KA, Frackelton EC, Chiavacci RM, Imielinski M, Monos DS, Pandey R, Bakay M, Grant SF, Polychronakos C, Hakonarson H. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. \u003ci\u003ePLoS Genet\u003c/i\u003e 2011 Sep;7(9):e1002293. Epub 2011 Sep 29.\u003c/span\u003e","author":"Monos DS, Bakay M, Hakonarson H, Polychronakos C, Grant SF, Sleiman PM, Kim CE, Bradfield JP, Mentch FD, Qiu H, Glessner JT, Thomas KA, Frackelton EC, Chiavacci RM, Imielinski M, Qu HQ, Wang K, Zhang H, Pandey R","study_acronym":"T1DGC","study_type":"Observational","abstract":"Diabetes impacts approximately 200 million people worldwide, of whom approximately 10% are affected by type 1 diabetes (T1D). The application of genome-wide association studies (GWAS) has robustly revealed dozens of genetic contributors to the pathogenesis of T1D, with the most recent meta-analysis identifying in excess of 40 loci. To identify additional genetic loci for T1D susceptibility, we examined associations in the largest meta-analysis to date between the disease and ∼2.54 million SNPs in a combined cohort of 9,934 cases and 16,956 controls. Targeted follow-up of 53 SNPs in 1,120 affected trios uncovered three new loci associated with T1D that reached genome-wide significance. The most significantly associated SNP (rs539514, P = 5.66×10⁻¹¹) resides in an intronic region of the LMO7 (LIM domain only 7) gene on 13q22. The second most significantly associated SNP (rs478222, P = 3.50×10⁻⁹ resides in an intronic region of the EFR3B (protein EFR3 homolog B) gene on 2p23; however, the region of linkage disequilibrium is approximately 800 kb and harbors additional multiple genes, including NCOA1, C2orf79, CENPO, ADCY3, DNAJC27, POMC, and DNMT3A. The third most significantly associated SNP (rs924043, P = 8.06×10⁻⁹ lies in an intergenic region on 6q27, where the region of association is approximately 900 kb and harbors multiple genes including WDR27, C6orf120, PHF10, TCTE3, C6orf208, LOC154449, DLL1, FAM120B, PSMB1, TBP, and PCD2. These latest associated regions add to the growing repertoire of gene networks predisposing to T1D.","@timestamp":"2024-11-26T23:52:42.986Z","study_name_array":["Type 1 Diabetes Genetics Consortium"],"pmcid":"PMC3183083","publication_year":2011,"study_acronym_array":["T1DGC"],"publication_origin":"Secondary Research","study_type_array":["Observational"]},"sort":["A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci."]},{"_index":"publications_v001","_id":"_cLkapMBHb0XhPerUtgT","_score":null,"_source":{"affiliation":"Department of Computer Sciences, Columbia University, New York, New York, United States of America.","request_id_array":null,"doi":"10.1371/journal.pgen.1002559","request_id":null,"study_name":"Inflammatory Bowel Disease Genetics","author_array":["Ullman T","Barzilai N","Kenny EE","Pe'er I","Karban A","Ozelius L","Mitchell AA","Ng SM","Erazo M","Ostrer H","Abraham C","Abreu MT","Atzmon G","Warren ST","Waterman M","Zhang W","Bergman A","Mayer L","Katz S","Desnick RJ","Cho JH","Peter I","Brant SR","Bressman S","Burns ER","Chowers Y","Clark LN","Darvasi A","Doheny D","Duerr RH","Eliakim R","Giladi N","Gregersen PK","Hakonarson H","Jones MR","Marder K","McGovern DP","Mulle J","Orr-Urtreger A","Proctor DD","Pulver A","Rotter JI","Silverberg MS"],"@version":"1","id":1690,"title":"A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.","pmid":"22412388","publication_type":"Journal","citation":"\u003cspan\u003eKenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. \u003ci\u003ePLoS Genet\u003c/i\u003e 2012;8(3):e1002559. Epub 2012 Mar 8.\u003c/span\u003e","author":"Ullman T, Barzilai N, Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS","study_acronym":"IBD","study_type":"Observational","abstract":"Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal microbiota with the host immune system in genetically susceptible individuals. The largest meta-analysis of genome-wide association to date identified 71 CD-susceptibility loci in individuals of European ancestry. An important epidemiological feature of CD is that it is 2-4 times more prevalent among individuals of Ashkenazi Jewish (AJ) descent compared to non-Jewish Europeans (NJ). To explore genetic variation associated with CD in AJs, we conducted a genome-wide association study (GWAS) by combining raw genotype data across 10 AJ cohorts consisting of 907 cases and 2,345 controls in the discovery stage, followed up by a replication study in 971 cases and 2,124 controls. We confirmed genome-wide significant associations of 9 known CD loci in AJs and replicated 3 additional loci with strong signal (p\u0026lt;5×10⁻⁶). Novel signals detected among AJs were mapped to chromosomes 5q21.1 (rs7705924, combined p = 2×10⁻⁸; combined odds ratio OR = 1.48), 2p15 (rs6545946, p = 7×10⁻⁹; OR = 1.16), 8q21.11 (rs12677663, p = 2×10⁻⁸; OR = 1.15), 10q26.3 (rs10734105, p = 3×10⁻⁸; OR = 1.27), and 11q12.1 (rs11229030, p = 8×10⁻⁹; OR = 1.15), implicating biologically plausible candidate genes, including RPL7, CPAMD8, PRG2, and PRG3. In all, the 16 replicated and newly discovered loci, in addition to the three coding NOD2 variants, accounted for 11.2% of the total genetic variance for CD risk in the AJ population. This study demonstrates the complementary value of genetic studies in the Ashkenazim.","@timestamp":"2024-11-26T23:52:42.963Z","study_name_array":["Inflammatory Bowel Disease Genetics"],"pmcid":"PMC3297573","publication_year":2012,"study_acronym_array":["IBD"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci."]},{"_index":"publications_v001","_id":"Df3kapMBC2xkvCSBUxXQ","_score":null,"_source":{"affiliation":"Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America.","request_id_array":null,"doi":"10.1371/journal.pone.0076978","request_id":null,"study_name":"Inflammatory Bowel Disease Genetics","author_array":["Tsang KM","Delorenze GN","Weiss LA","Yoshida CK","Zerbo O","Windham GC","Croen LA","Kharrazi M","Torres AR"],"@version":"1","id":1557,"title":"A genome-wide survey of transgenerational genetic effects in autism.","pmid":"24204716","publication_type":"Journal","citation":"\u003cspan\u003eTsang KM, Croen LA, Torres AR, Kharrazi M, Delorenze GN, Windham GC, Yoshida CK, Zerbo O, Weiss LA. A genome-wide survey of transgenerational genetic effects in autism. \u003ci\u003ePLoS One\u003c/i\u003e 2013 Oct 24;8(10):e76978. doi: 10.1371/journal.pone.0076978. eCollection 2013.\u003c/span\u003e","author":"Tsang KM, Delorenze GN, Weiss LA, Yoshida CK, Zerbo O, Windham GC, Croen LA, Kharrazi M, Torres AR","study_acronym":"IBD","study_type":"Observational","abstract":"Effects of parental genotype or parent-offspring genetic interaction are well established in model organisms for a variety of traits. However, these transgenerational genetic models are rarely studied in humans. We have utilized an autism case-control study with 735 mother-child pairs to perform genome-wide screening for maternal genetic effects and maternal-offspring genetic interaction. We used simple models of single locus parent-child interaction and identified suggestive results (P\u0026lt;10(-4)) that cannot be explained by main effects, but no genome-wide significant signals. Some of these maternal and maternal-child associations were in or adjacent to autism candidate genes including: PCDH9, FOXP1, GABRB3, NRXN1, RELN, MACROD2, FHIT, RORA, CNTN4, CNTNAP2, FAM135B, LAMA1, NFIA, NLGN4X, RAPGEF4, and SDK1. We attempted validation of potential autism association under maternal-specific models using maternal-paternal comparison in family-based GWAS datasets. Our results suggest that further study of parental genetic effects and parent-child interaction in autism is warranted. ","@timestamp":"2024-11-26T23:52:42.999Z","study_name_array":["Inflammatory Bowel Disease Genetics"],"pmcid":"PMC3811986","publication_year":2013,"study_acronym_array":["IBD"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A genome-wide survey of transgenerational genetic effects in autism."]},{"_index":"publications_v001","_id":"xv3kapMBC2xkvCSBSRKu","_score":null,"_source":{"affiliation":"Immunogenetics Laboratory and MediCity Research Laboratory, University of Turku, Finland. minna.kiviniemi@utu.fi","request_id_array":null,"doi":"10.1089/dia.2007.0229","request_id":null,"study_name":"The Environmental Determinants of Diabetes in the Young","author_array":["Simell O","Hermann R","Kiviniemi M","Ilonen J","Ziegler AG","Nurmi J","TEDDY Study Group","Knip M","Lövgren T","Veijola R"],"@version":"1","id":2362,"title":"A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study.","pmid":"17931054","publication_type":"Journal","citation":"\u003cspan\u003eKiviniemi M, Hermann R, Nurmi J, Ziegler AG, Knip M, Simell O, Veijola R, Lövgren T, Ilonen J, TEDDY Study Group. A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study. \u003ci\u003eDiabetes Technol Ther\u003c/i\u003e 2007 Oct;9(5):460-72.\u003c/span\u003e","author":"Simell O, Hermann R, Kiviniemi M, Ilonen J, Ziegler AG, Nurmi J, TEDDY Study Group, Knip M, Lövgren T, Veijola R","study_acronym":"TEDDY","study_type":"Observational","abstract":"In the TEDDY (The Environmental Determinants of Diabetes in the Young) study patient eligibility is based on the presence of some selected type 1 diabetes risk-associated human leukocyte antigen DR-DQ genotypes. A practical screening strategy was needed with efficient exclusion of ineligible patients at an early stage. Also, a simple, low-cost, and fast screening system was essential for the primary step of the risk assessment including thousands of samples.","@timestamp":"2024-11-26T23:52:43.059Z","study_name_array":["The Environmental Determinants of Diabetes in the Young"],"pmcid":"","publication_year":2007,"study_acronym_array":["TEDDY"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study."]},{"_index":"publications_v001","_id":"OP3kapMBC2xkvCSBTRQW","_score":null,"_source":{"affiliation":"Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA. pjc6n@virginia.edu","request_id_array":null,"doi":"10.2337/db08-0753","request_id":null,"study_name":"Type 1 Diabetes Genetics Consortium","author_array":["Smyth DJ","Chen WM","Morahan G","Type 1 Diabetes Genetics Consortium","Rich SS","Julier C","Hilner JE","Erlich HA","Akolkar B","Pociot F","Concannon P","Onengut-Gumuscu S","Todd JA","Bergholdt R","Nierras CR","Nerup J"],"@version":"1","id":2257,"title":"A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.","pmid":"18647951","publication_type":"Journal","citation":"\u003cspan\u003eConcannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS, Type 1 Diabetes Genetics Consortium. A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. \u003ci\u003eDiabetes\u003c/i\u003e 2008 Oct;57(10):2858-61. Epub 2008 Jul 22.\u003c/span\u003e","author":"Smyth DJ, Chen WM, Morahan G, Type 1 Diabetes Genetics Consortium, Rich SS, Julier C, Hilner JE, Erlich HA, Akolkar B, Pociot F, Concannon P, Onengut-Gumuscu S, Todd JA, Bergholdt R, Nierras CR, Nerup J","study_acronym":"T1DGC","study_type":"Observational","abstract":"The Type 1 Diabetes Genetics Consortium (T1DGC) has assembled and genotyped a large collection of multiplex families for the purpose of mapping genomic regions linked to type 1 diabetes. In the current study, we tested for evidence of loci associated with type 1 diabetes utilizing genome-wide linkage scan data and family-based association methods.","@timestamp":"2024-11-26T23:52:43.051Z","study_name_array":["Type 1 Diabetes Genetics Consortium"],"pmcid":"PMC2551699","publication_year":2008,"study_acronym_array":["T1DGC"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3."]},{"_index":"publications_v001","_id":"B8LkapMBHb0XhPerTdiI","_score":null,"_source":{"affiliation":"PricewaterhouseCoopers LLP, New York, New York, United States of America.","request_id_array":["20879"],"doi":"10.1371/journal.pone.0192472","request_id":"20879","study_name":"Diabetes Prevention Program, Diabetes Prevention Program Outcomes Study","author_array":["Chelini CM","Sheu IE","Chen Q","Dwivedi G","Sarkar J","Paich M","Burns SP","D'Alessandro PM"],"@version":"1","id":1066,"title":"A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual.","pmid":"29444133","publication_type":"Journal","citation":"\u003cspan\u003eSarkar J, Dwivedi G, Chen Q, Sheu IE, Paich M, Chelini CM, D'Alessandro PM, Burns SP. A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual. \u003ci\u003ePLoS One\u003c/i\u003e 2018 Feb 14;13(2):e0192472. doi: 10.1371/journal.pone.0192472. eCollection 2018.\u003c/span\u003e","author":"Chelini CM, Sheu IE, Chen Q, Dwivedi G, Sarkar J, Paich M, Burns SP, D'Alessandro PM","study_acronym":"DPP, DPPOS","study_type":"Interventional","abstract":"A computational model of the physiological mechanisms driving an individual's health towards onset of type 2 diabetes (T2D) is described, calibrated and validated using data from the Diabetes Prevention Program (DPP). The objective of this model is to quantify the factors that can be used for prevention of T2D. The model is energy and mass balanced and continuously simulates trajectories of variables including body weight components, fasting plasma glucose, insulin, and glycosylated hemoglobin among others on the time-scale of years. Modeled mechanisms include dynamic representations of intracellular insulin resistance, pancreatic beta-cell insulin production, oxidation of macronutrients, ketogenesis, effects of inflammation and reactive oxygen species, and conversion between stored and activated metabolic species, with body-weight connected to mass and energy balance. The model was calibrated to 331 placebo and 315 lifestyle-intervention DPP subjects, and one year forecasts of all individuals were generated. Predicted population mean errors were less than or of the same magnitude as clinical measurement error; mean forecast errors for weight and HbA1c were ~5%, supporting predictive capabilities of the model. Validation of lifestyle-intervention prediction is demonstrated by synthetically imposing diet and physical activity changes on DPP placebo subjects. Using subject level parameters, comparisons were made between exogenous and endogenous characteristics of subjects who progressed toward T2D (HbA1c \u0026gt; 6.5) over the course of the DPP study to those who did not. The comparison revealed significant differences in diets and pancreatic sensitivity to hyperglycemia but not in propensity to develop insulin resistance. A computational experiment was performed to explore relative contributions of exogenous versus endogenous factors between these groups. Translational uses to applications in public health and personalized healthcare are discussed.","@timestamp":"2024-11-26T23:52:42.971Z","study_name_array":["Diabetes Prevention Program","Diabetes Prevention Program Outcomes Study"],"pmcid":"PMC5812629","publication_year":2018,"study_acronym_array":["DPP","DPPOS"],"publication_origin":"Secondary Research","study_type_array":["Interventional"]},"sort":["A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual."]},{"_index":"publications_v001","_id":"FP3kapMBC2xkvCSBWBZR","_score":null,"_source":{"affiliation":"ivision of Endocrinology, University of Miami, Miami, Florida, USA. jsosenko@med.miami.edu","request_id_array":null,"doi":"10.2337/dc11-0981","request_id":null,"study_name":"Diabetes Prevention Trial of Type 1 Diabetes","author_array":["Eisenbarth G","Krischer JP","Yu L","Schatz DA","Orban T","Cuthbertson D","Sosenko JM","Skyler JS","Palmer JP","Diabetes Prevention Trial–Type 1 and Type 1 Diabetes TrialNet Study Groups"],"@version":"1","id":1752,"title":"A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants.","pmid":"21911777","publication_type":"Journal","citation":"\u003cspan\u003eSosenko JM, Skyler JS, Palmer JP, Krischer JP, Cuthbertson D, Yu L, Schatz DA, Orban T, Eisenbarth G, Diabetes Prevention Trial–Type 1 and Type 1 Diabetes TrialNet Study Groups. A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants. \u003ci\u003eDiabetes Care\u003c/i\u003e 2011 Nov;34(11):2435-7. Epub 2011 Sep 12.\u003c/span\u003e","author":"Eisenbarth G, Krischer JP, Yu L, Schatz DA, Orban T, Cuthbertson D, Sosenko JM, Skyler JS, Palmer JP, Diabetes Prevention Trial–Type 1 and Type 1 Diabetes TrialNet Study Groups","study_acronym":"DPT-1","study_type":"Interventional","abstract":"We examined changes in GAD65 and ICA-512 autoantibodies (GADA and IA-2A) during progression to type 1 diabetes (T1D).","@timestamp":"2024-11-26T23:52:43.015Z","study_name_array":["Diabetes Prevention Trial of Type 1 Diabetes"],"pmcid":"PMC3198298","publication_year":2011,"study_acronym_array":["DPT-1"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants."]},{"_index":"publications_v001","_id":"bsLkapMBHb0XhPerXtoZ","_score":null,"_source":{"affiliation":"a Department of Mathematics and Computer Science, Physical Sciences and Earth Sciences, University of Messina, Messina, Italy b Institute of Clinical Physiology - Reggio Calabria Unit, Laboratory of Bioinformatics, National Research Council, Italy c Department of Ancient and Modern Civilizations, University of Messina, Messina, Italy","request_id_array":["21866"],"doi":"10.1016/j.cmpb.2019.05.005","request_id":"21866","study_name":"Hemodialysis Study","author_array":["Vilasi A","Mezzatestaa S","Fiumaraa G","De Meoc P","Torino C"],"@version":"1","id":231,"title":"A machine learning-based approach for predicting the outbreak of\ncardiovascular diseases in patients on dialysis","pmid":"31319965","publication_type":"Journal","citation":null,"author":"Vilasi A, Mezzatestaa S, Fiumaraa G, De Meoc P, Torino C","study_acronym":"HEMO","study_type":"Interventional","abstract":"Background and Objective: Patients with End- Stage Kidney Disease (ESKD) have a unique cardiovascular\nrisk. This study aims at predicting, with a certain precision, death and cardiovascular diseases in dialysis\npatients.\nMethods: To achieve our aim, machine learning techniques have been used. Two datasets have been taken\ninto consideration: the first is an Italian dataset obtained from the Istituto di Fisiologia Clinica of Consiglio\nNazionale delle Ricerche of Reggio Calabria; the second is an American dataset provided by the National\nInstitute of Diabetes and Digestive and Kidney Diseases (NIDDK) repository. From each one we obtained\n5 datasets, according to the outcome of interest. We tested different types of algorithm (both linear and\nnon-linear), but the final choice was to use Support Vector Machine. In particular, we obtained the best\nperformances using the non-linear SVC with RBF kernel algorithm, optimizing it with GridSearch. The last\nis an algorithm useful to search the best combination of hyper-parameters (in our case, to find the best\ncouple (C, ? )), in order to improve the accuracy of the algorithm.\nResults: The use of non-linear SVC with RBF kernel algorithm, optimized with GridSearch, allowed to\nobtain an accuracy of 95.25% in the Italian dataset and of 92.15% in the American dataset, in a timeframe\nof 2.5 years,in the prediction of Ischaemic Heart Disease. A worse performance was obtained for the other\noutcomes.\nConclusions: The machine learning-based approach applied in our study is able to predict, with a high\naccuracy, the outbreak of cardiovascular diseases in patients on dialysis.","@timestamp":"2024-11-26T23:52:43.112Z","study_name_array":["Hemodialysis Study"],"pmcid":null,"publication_year":2019,"study_acronym_array":["HEMO"],"publication_origin":"Secondary Research","study_type_array":["Interventional"]},"sort":["A machine learning-based approach for predicting the outbreak of\ncardiovascular diseases in patients on dialysis"]},{"_index":"publications_v001","_id":"5_3kapMBC2xkvCSBSRKu","_score":null,"_source":{"affiliation":" Division of Nephrology, Tufts Medical Center, Boston, MA USA\n Population Health Sciences, University of Utah School of Medicine, UT, USA\n Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands\n Renal and Metabolic Division, the George Institute for Global Health, NSW, Australia\n Instituto de Investigación Hospital 12 de octubre (i+12), Madrid, Spain\n Division of Nephrology, RWTH Aachen University, Aachen, Germany\n Department of Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain\n Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK\n Nakayamadera Imai Clinic, Takarazuka, Japan\n Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore\n Division of Nephrology, Vanderbilt University, Nashville, TN, USA\n Division of Nephrology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong\n Department of Nephrology, AZ Delta, Roeselare, Belgium\n Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy\n Renal, Dialysis and Transplant Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy\n Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA\n Department of Nephrology and Dialysis, Sant’Anna Hospital, ASST Lariana, 22042 Como, Italy\n Division of Nephrology, University Hospital of Würzburg, Würzburg, Germany\n The George Institute for Global Health, University of New South Wales, Sydney, Australia\n Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China\n","request_id_array":["22864","23584"],"doi":"10.1038/s41591-023-02418-0","request_id":"22864, 23584","study_name":"The HALT Progression of Polycystic Kidney Disease, Novel Therapies to Treat Resistant Focal Segmental Glomerulosclerosis: Phase II Clinical Trial, FONT 2 Study: Novel Therapies for Resistant FSGS Phase II Clinical Trials","author_array":["Haaland B","Inker LA","Collier W","Greene T","Miao S","Chaudhari J","Appel GB","Badve SV","Caravaca-Fontán F","del Vecchio L","Floege J","Goicoechea M","Herrington WG","Imai E","Jafar TH","Lewis JB","Li PKT","Maes BD","Neuen BL","Perrone RD","Remuzzi G","Schena FP","Wanner C","Wetzels JFM","Woodward M","Heerspink HJL"],"@version":"1","id":157,"title":"A meta-analysis of GFR slope as a surrogate endpoint for kidney failure","pmid":"37330614","publication_type":"Journal","citation":null,"author":"Haaland B, Inker LA, Collier W, Greene T, Miao S, Chaudhari J, Appel GB, Badve SV, Caravaca-Fontán F, del Vecchio L, Floege J, Goicoechea M, Herrington WG, Imai E, Jafar TH, Lewis JB, Li PKT, Maes BD, Neuen BL, Perrone RD, Remuzzi G, Schena FP, Wanner C, Wetzels JFM, Woodward M, Heerspink HJL","study_acronym":"HALT PKD, FSGS/FONT, FONT II","study_type":"Interventional","abstract":"Glomerular filtration rate (GFR) decline is causally associated with kidney failure and is a candidate surrogate endpoint for clinical trials of chronic kidney disease (CKD) progression. Analyses across a diverse spectrum of interventions and populations is required for acceptance of GFR decline as an endpoint. In an analysis of individual participant data, for each of 66 studies (total of 186,312 participants), we estimated treatment effects on the total GFR slope, computed from baseline to 3 years, and chronic slope, starting at 3 months after randomization, and on the clinical endpoint (doubling of serum creatinine, GFR \u003c 15 ml min−1 per 1.73 m2 or kidney failure with replacement therapy). We used a Bayesian mixed-effects meta-regression model to relate treatment effects on GFR slope with those on the clinical endpoint across all studies and by disease groups (diabetes, glomerular diseases, CKD or cardiovascular diseases). Treatment effects on the clinical endpoint were strongly associated with treatment effects on total slope (median coefficient of determination (R2) = 0.97 (95% Bayesian credible interval (BCI) 0.82–1.00)) and moderately associated with those on chronic slope (R2 = 0.55 (95% BCI 0.25–0.77)). There was no evidence of heterogeneity across disease. Our results support the use of total slope as a primary endpoint for clinical trials of CKD progression.","@timestamp":"2024-11-26T23:52:43.101Z","study_name_array":["The HALT Progression of Polycystic Kidney Disease","Novel Therapies to Treat Resistant Focal Segmental Glomerulosclerosis: Phase II Clinical Trial","FONT 2 Study: Novel Therapies for Resistant FSGS Phase II Clinical Trials"],"pmcid":null,"publication_year":2023,"study_acronym_array":["HALT PKD","FSGS/FONT","FONT II"],"publication_origin":"Secondary Research","study_type_array":["Interventional"]},"sort":["A meta-analysis of GFR slope as a surrogate endpoint for kidney failure"]},{"_index":"publications_v001","_id":"6f3kapMBC2xkvCSBWBVR","_score":null,"_source":{"affiliation":"Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland. heikki.hyoty@uta.fi.","request_id_array":null,"doi":"10.1186/s12887-015-0333-8","request_id":null,"study_name":"The Environmental Determinants of Diabetes in the Young","author_array":["Hummel M","Beyerlein A","Ziegler AG","Anderson SW","Foghis G","Williams J","Sharma A","Nechtman J","Liu H","McIndoe R","Gardiner M","Sheehan E","Shankar M","Haller M","Silvis K","Thomas J","Steed L","Hopkins D","Schatz D","She JX","Davis B","Steck A","Samper-Imaz A","Waugh K","Norris J","Liu E","Karban R","Ide L","Hoffman M","Gesualdo P","Frank N","Eisenbarth G","Bedoy R","Baxter J","Bautista K","Barriga K","Rewers M","TEDDY Study Group","Hyöty H","Krischer J","Akolkar B","Ziegler AG","Simell O","She JX","Hagopian W","Rewers M","Lernmark Å","Larsson HE","Lynch K","Lönnrot M","Broadhurst J","Carreno G","Caygill C","Curnock R","Easton P","Geoghan I","Goode J","Long A","Payne M","Pearson J","Reed C","Ridewood S","Wyatt R","Davis B","Eriksson EA","Karlsson EL","Erlund I","Salminen I","Sundvall J","Leiviskä J","Lehtonen M","Little RR","Tennill AL","Erlich H","Mack SJ","Fear AL","Fiehn O","Wikoff B","Kind T","Palazoglu M","Wong J","Wohlgemuth G","Petrosino JF","Marcovina SM","Gaur VP","Higgins H","Ke S","She JX","McIndoe R","Liu H","Nechtman J","Zhao Y","Jiang N","Rich SS","Chen WM","Onengut-Gumuscu S","Farber E","Pickin RR","Davis J","Gallo D","Boldison J","Butterly J","Rokni S","Chandler K","Williams A","Bingley P","Miao D","Yu L","Triplett E","Oberste S","Johnson SB","Briese T","Bourcier K","Akolkar B","Yang J","Vehik K","Uusitalo U","Tamura R","Smith S","Smith L","McLeod W","McCarthy C","Malloy J","Lynch K","Liu X","Liu S","Lee HS","Hadley D","Gowda V","Fiske S","Eberhard C","Cuthbertson D","Butterworth M","Burkhardt B","Brown R","Austin-Gonzalez S","Abbondondolo M","Krischer JP","Klein MB","Daftary A","Smith MD","Franciscus M","Becker D","Willis J","Williams N","Stabbert J","Scott E","Mulenga D","Meyer A","Kindschi R","Hervey R","Heaney D","Dunson K","Ayres S","Skidmore J","Crouch CC","Killian M","Yan X","Hagopian WA","Åberg S","Wimar Å","Wallin A","Törn C","Trulsson E","Swartling U","Sjöberg B","Sibthorpe S","Järvirova MS","Rosenquist A","Ramelius A","Rahmati K","Mestan Z","Melin J","Massadakis T","Markan M","Månsson-Martinez M","Lernmark B","Larsson H","Jonsson L","Jonasdottir B","Johansen F","Hyberg S","Hansson G","Hansen M","Håkansson R","Gerardsson J","Gard T","Fransson L","Ericson-Hallström E","Cilio C","Carlsson UM","Bremer J","Ask M","Andrén-Aronsson C","Agardh D","Lernmark Å","Åkerlund M","Virtanen SM","Veijola R","Varjonen E","Stenius A","Sjöberg M","Simell V","Simell T","Simell S","Simell B","Simell A","Romo M","Riikonen A","Rautanen J","Nyblom M","Niininen T","Näntö-Salonen K","Mykkänen J","Multasuo K","Mäntymäki E","Lönnrot M","Kurppa K","Koreasalo M","Koivu A","Knip M","Kähönen M","Ilonen J","Hyöty H","Toppari J","Simell OG","Winkler C","Warncke K","Strauss E","Stock J","Schenkel J","Roth R","Peplow C","Koletzko S","Knopff A","Kersting M","Foterek K","Hummel S","Bonifacio E"],"@version":"1","id":1218,"title":"A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY.","pmid":"25884839","publication_type":"Journal","citation":"\u003cspan\u003eLönnrot M, Lynch K, Larsson HE, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Ziegler AG, Akolkar B, Krischer J, Hyöty H, TEDDY Study Group. A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY. \u003ci\u003eBMC Pediatr\u003c/i\u003e 2015 Mar 20;15:24.\u003c/span\u003e","author":"Hummel M, Beyerlein A, Ziegler AG, Anderson SW, Foghis G, Williams J, Sharma A, Nechtman J, Liu H, McIndoe R, Gardiner M, Sheehan E, Shankar M, Haller M, Silvis K, Thomas J, Steed L, Hopkins D, Schatz D, She JX, Davis B, Steck A, Samper-Imaz A, Waugh K, Norris J, Liu E, Karban R, Ide L, Hoffman M, Gesualdo P, Frank N, Eisenbarth G, Bedoy R, Baxter J, Bautista K, Barriga K, Rewers M, TEDDY Study Group, Hyöty H, Krischer J, Akolkar B, Ziegler AG, Simell O, She JX, Hagopian W, Rewers M, Lernmark Å, Larsson HE, Lynch K, Lönnrot M, Broadhurst J, Carreno G, Caygill C, Curnock R, Easton P, Geoghan I, Goode J, Long A, Payne M, Pearson J, Reed C, Ridewood S, Wyatt R, Davis B, Eriksson EA, Karlsson EL, Erlund I, Salminen I, Sundvall J, Leiviskä J, Lehtonen M, Little RR, Tennill AL, Erlich H, Mack SJ, Fear AL, Fiehn O, Wikoff B, Kind T, Palazoglu M, Wong J, Wohlgemuth G, Petrosino JF, Marcovina SM, Gaur VP, Higgins H, Ke S, She JX, McIndoe R, Liu H, Nechtman J, Zhao Y, Jiang N, Rich SS, Chen WM, Onengut-Gumuscu S, Farber E, Pickin RR, Davis J, Gallo D, Boldison J, Butterly J, Rokni S, Chandler K, Williams A, Bingley P, Miao D, Yu L, Triplett E, Oberste S, Johnson SB, Briese T, Bourcier K, Akolkar B, Yang J, Vehik K, Uusitalo U, Tamura R, Smith S, Smith L, McLeod W, McCarthy C, Malloy J, Lynch K, Liu X, Liu S, Lee HS, Hadley D, Gowda V, Fiske S, Eberhard C, Cuthbertson D, Butterworth M, Burkhardt B, Brown R, Austin-Gonzalez S, Abbondondolo M, Krischer JP, Klein MB, Daftary A, Smith MD, Franciscus M, Becker D, Willis J, Williams N, Stabbert J, Scott E, Mulenga D, Meyer A, Kindschi R, Hervey R, Heaney D, Dunson K, Ayres S, Skidmore J, Crouch CC, Killian M, Yan X, Hagopian WA, Åberg S, Wimar Å, Wallin A, Törn C, Trulsson E, Swartling U, Sjöberg B, Sibthorpe S, Järvirova MS, Rosenquist A, Ramelius A, Rahmati K, Mestan Z, Melin J, Massadakis T, Markan M, Månsson-Martinez M, Lernmark B, Larsson H, Jonsson L, Jonasdottir B, Johansen F, Hyberg S, Hansson G, Hansen M, Håkansson R, Gerardsson J, Gard T, Fransson L, Ericson-Hallström E, Cilio C, Carlsson UM, Bremer J, Ask M, Andrén-Aronsson C, Agardh D, Lernmark Å, Åkerlund M, Virtanen SM, Veijola R, Varjonen E, Stenius A, Sjöberg M, Simell V, Simell T, Simell S, Simell B, Simell A, Romo M, Riikonen A, Rautanen J, Nyblom M, Niininen T, Näntö-Salonen K, Mykkänen J, Multasuo K, Mäntymäki E, Lönnrot M, Kurppa K, Koreasalo M, Koivu A, Knip M, Kähönen M, Ilonen J, Hyöty H, Toppari J, Simell OG, Winkler C, Warncke K, Strauss E, Stock J, Schenkel J, Roth R, Peplow C, Koletzko S, Knopff A, Kersting M, Foterek K, Hummel S, Bonifacio E","study_acronym":"TEDDY","study_type":"Observational","abstract":"Early childhood environmental exposures, possibly infections, may be responsible for triggering islet autoimmunity and progression to type 1 diabetes (T1D). The Environmental Determinants of Diabetes in the Young (TEDDY) follows children with increased HLA-related genetic risk for future T1D. TEDDY asks parents to prospectively record the child's infections using a diary book. The present paper shows how these large amounts of partially structured data were reduced into quantitative data-sets and further categorized into system-specific infectious disease episodes. The numbers and frequencies of acute infections and infectious episodes are shown.","@timestamp":"2024-11-26T23:52:42.925Z","study_name_array":["The Environmental Determinants of Diabetes in the Young"],"pmcid":"PMC4377063","publication_year":2015,"study_acronym_array":["TEDDY"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY."]},{"_index":"publications_v001","_id":"0_3kapMBC2xkvCSBUBSm","_score":null,"_source":{"affiliation":"Department of Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Ohio 44195, USA. tgreene@bio.ri.ccf.org","request_id_array":null,"doi":"10.1111/j.0006-341x.2001.00354.x","request_id":null,"study_name":"Modification of Diet in Renal Disease","author_array":["Greene T"],"@version":"1","id":2871,"title":"A model for a proportional treatment effect on disease progression.","pmid":"11414556","publication_type":"Journal","citation":"\u003cspan\u003eGreene T. A model for a proportional treatment effect on disease progression. \u003ci\u003eBiometrics\u003c/i\u003e 2001 Jun;57(2):354-60.\u003c/span\u003e","author":"Greene T","study_acronym":"MDRD","study_type":"Interventional","abstract":"Treatments intended to slow the progression of chronic diseases are often hypothesized to reduce the rate of further injury to a biological system without improving the current level of functioning. In this situation, the treatment effect may be negligible for patients whose disease would have been stable without the treatment but would be expected to be an increasing function of the progression rate in patients with worsening disease. This article considers a variation of the Laird Ware mixed effects model in which the effect of the treatment on the slope of a longitudinal outcome is assumed to be proportional to the progression rate for patients with progressive disease. Inference based on maximum likelihood and a generalized estimating equations procedure is considered. Under the proportional effect assumption, the precision of the estimated treatment effect can be increased by incorporating the functional relationship between the model parameters and the variance of the outcome variable, particularly when the magnitude of the mean slope of the outcome is small compared with the standard deviation of the slopes. An example from a study of chronic renal disease is used to illustrate insights provided by the proportional effect model that may be overlooked with models assuming additive treatment effects.","@timestamp":"2024-11-26T23:52:43.086Z","study_name_array":["Modification of Diet in Renal Disease"],"pmcid":"","publication_year":2001,"study_acronym_array":["MDRD"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["A model for a proportional treatment effect on disease progression."]},{"_index":"publications_v001","_id":"_sLkapMBHb0XhPerUtgT","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis","author_array":["Rao M","Xu H","Jegga AG","Bezerra JA","Shivakumar P","Bessho K","Mourya R","Dilbone E","Kaimal V"],"@version":"1","id":1715,"title":"A molecular signature of biliary atresia highly distinct from other cholestatic diseases at diagnosis","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eBessho K, Mourya R, Dilbone E, Kaimal V, Xu H, Shivakumar P, Rao M, Jegga AG, Bezerra JA. A molecular signature of biliary atresia highly distinct from other cholestatic diseases at diagnosis. \u003ci\u003eProceedings of American Association for the Study of Liver Diseases (AASLD) 62nd Annual Meeting\u003c/i\u003e; November 4-8, 2011; San Francisco, CA. 2011 Nov.\u003c/span\u003e","author":"Rao M, Xu H, Jegga AG, Bezerra JA, Shivakumar P, Bessho K, Mourya R, Dilbone E, Kaimal V","study_acronym":"PROBE","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:42.965Z","study_name_array":["A Prospective Database of Infants With Cholestasis"],"pmcid":"","publication_year":2011,"study_acronym_array":["PROBE"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A molecular signature of biliary atresia highly distinct from other cholestatic diseases at diagnosis"]},{"_index":"publications_v001","_id":"ocLkapMBHb0XhPerVtmK","_score":null,"_source":{"affiliation":"Department of Health Behavior and Health Education, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 7205, USA. WestDelia@uams.edu","request_id_array":null,"doi":"10.1038/ijo.2010.138","request_id":null,"study_name":"Program to Reduce Incontinence by Diet and Exercise","author_array":["Wing RR","West DS","Gorin AA","Subak LL","Foster G","Bragg C","Hecht J","Schembri M","Program to Reduce Incontinence by Diet and Exercise (PRIDE) Research Group"],"@version":"1","id":1958,"title":"A motivation-focused weight loss maintenance program is an effective alternative to a skill-based approach.","pmid":"20680012","publication_type":"Journal","citation":"\u003cspan\u003eWest DS, Gorin AA, Subak LL, Foster G, Bragg C, Hecht J, Schembri M, Wing RR, Program to Reduce Incontinence by Diet and Exercise (PRIDE) Research Group. A motivation-focused weight loss maintenance program is an effective alternative to a skill-based approach. \u003ci\u003eInt J Obes (Lond)\u003c/i\u003e 2011 Feb;35(2):259-69. Epub 2010 Aug 3.\u003c/span\u003e","author":"Wing RR, West DS, Gorin AA, Subak LL, Foster G, Bragg C, Hecht J, Schembri M, Program to Reduce Incontinence by Diet and Exercise (PRIDE) Research Group","study_acronym":"PRIDE","study_type":"Interventional","abstract":"Maintaining weight loss is a major challenge in obesity treatment. Individuals often indicate that waning motivation prompts cessation of effective weight management behaviors. Therefore, a novel weight loss maintenance program that specifically targets motivational factors was evaluated.","@timestamp":"2024-11-26T23:52:43.026Z","study_name_array":["Program to Reduce Incontinence by Diet and Exercise"],"pmcid":"PMC2974962","publication_year":2011,"study_acronym_array":["PRIDE"],"publication_origin":"Contributing Study","study_type_array":["Interventional"]},"sort":["A motivation-focused weight loss maintenance program is an effective alternative to a skill-based approach."]},{"_index":"publications_v001","_id":"0MLkapMBHb0XhPerT9gh","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis","author_array":["BARC","Whitington P","Sokol R","Bucuvalas J","Brown M","Shneider B","Robuck P","Rosenthal P","Shepherd R","Haber B","Squires R","Schwarz K"],"@version":"1","id":2647,"title":"A multi-center analysis of outcome at 24 months of age in children with biliary atresia in the United States","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eShneider B, Brown M, Sokol R, Whitington P, Schwarz K, Squires R, Bucuvalas J, Haber B, Shepherd R, Rosenthal P, Robuck P, BARC. A multi-center analysis of outcome at 24 months of age in children with biliary atresia in the United States. \u003ci\u003eProceedings of American Association for the Study of Liver Disease (AASLD) 55th Annual Meeting\u003c/i\u003e; October 29-November 2, 2004; Boston, MA. 2004 Oct.\u003c/span\u003e","author":"BARC, Whitington P, Sokol R, Bucuvalas J, Brown M, Shneider B, Robuck P, Rosenthal P, Shepherd R, Haber B, Squires R, Schwarz K","study_acronym":"PROBE","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:43.077Z","study_name_array":["A Prospective Database of Infants With Cholestasis"],"pmcid":"","publication_year":2004,"study_acronym_array":["PROBE"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A multi-center analysis of outcome at 24 months of age in children with biliary atresia in the United States"]},{"_index":"publications_v001","_id":"R_3kapMBC2xkvCSBTRQW","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis, Biliary Atresia Research Consortium","author_array":["Jaffe R","BARC","Russo P","Boitnott J","Bove K","Brown M","Finegold M","Haas J","Kim G","Magee J","Magid M","Melin-Aldana H","Sokol R","White F"],"@version":"1","id":2492,"title":"A multi-institutional study of interobserver agreement on the histologic diagnosis of biliary obstruction in liver biopsies of cholestatic infants less than six months of age","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eRusso P, Boitnott J, Bove K, Brown M, Finegold M, Haas J, Jaffe R, Kim G, Magee J, Magid M, Melin-Aldana H, Sokol R, White F, BARC. A multi-institutional study of interobserver agreement on the histologic diagnosis of biliary obstruction in liver biopsies of cholestatic infants less than six months of age. \u003ci\u003eProceedings of American Association for the Study of Liver Diseases (AASLD) 57th Annual Meeting\u003c/i\u003e; October 27-31, 2006; Boston, MA. 2006 Oct.\u003c/span\u003e","author":"Jaffe R, BARC, Russo P, Boitnott J, Bove K, Brown M, Finegold M, Haas J, Kim G, Magee J, Magid M, Melin-Aldana H, Sokol R, White F","study_acronym":"PROBE, BARC","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:43.067Z","study_name_array":["A Prospective Database of Infants With Cholestasis","Biliary Atresia Research Consortium"],"pmcid":"","publication_year":2006,"study_acronym_array":["PROBE","BARC"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A multi-institutional study of interobserver agreement on the histologic diagnosis of biliary obstruction in liver biopsies of cholestatic infants less than six months of age"]},{"_index":"publications_v001","_id":"T_3kapMBC2xkvCSBShPA","_score":null,"_source":{"affiliation":"Department of Pediatrics, Mount Sinai Medical Center, New York, NY 10029, Department of Biostatistics, University of Michigan, Ann Arbor, MI, and Department of Pediatrics, Children's Hospital of Philadelphia, PA, USA. Benjamin.Shneider@mssm.edu","request_id_array":null,"doi":"10.1016/j.jpeds.2005.12.054","request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis, Biliary Atresia Research Consortium","author_array":["Bezerra J","Biliary Atresia Research Consortium","Sokol RJ","Hoofnagle JH","Rosenthal P","Shepherd R","Squires R","Schwarz K","Whitington PF","Haber B","Brown MB","Shneider BL"],"@version":"1","id":2541,"title":"A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000.","pmid":"16647406","publication_type":"Journal","citation":"\u003cspan\u003eShneider BL, Brown MB, Haber B, Whitington PF, Schwarz K, Squires R, Bezerra J, Shepherd R, Rosenthal P, Hoofnagle JH, Sokol RJ, Biliary Atresia Research Consortium. A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000. \u003ci\u003eJ Pediatr\u003c/i\u003e 2006 Apr;148(4):467-474.\u003c/span\u003e","author":"Bezerra J, Biliary Atresia Research Consortium, Sokol RJ, Hoofnagle JH, Rosenthal P, Shepherd R, Squires R, Schwarz K, Whitington PF, Haber B, Brown MB, Shneider BL","study_acronym":"PROBE, BARC","study_type":"Observational","abstract":"To determine the prognostic factors and optimal approaches to the diagnosis and management of biliary atresia, the leading indication for liver transplantation in children.","@timestamp":"2024-11-26T23:52:43.071Z","study_name_array":["A Prospective Database of Infants With Cholestasis","Biliary Atresia Research Consortium"],"pmcid":null,"publication_year":2006,"study_acronym_array":["PROBE","BARC"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000."]},{"_index":"publications_v001","_id":"lcLkapMBHb0XhPerSddl","_score":null,"_source":{"affiliation":null,"request_id_array":null,"doi":null,"request_id":null,"study_name":null,"author_array":["Sirlin CB","Wolfson T","Gamst A","Middleton M","Hamilton G","Schwimmer J","Lavine JE","Behling C","Grimm PC","Yen T"],"@version":"1","id":2440,"title":"A multimodality correlation of hepatic steatosis in NAFLD","pmid":null,"publication_type":"Journal","citation":"\u003cspan\u003eYen T, Sirlin CB, Grimm PC, Wolfson T, Gamst A, Middleton M, Hamilton G, Behling C, Schwimmer J, Lavine JE. A multimodality correlation of hepatic steatosis in NAFLD. \u003ci\u003eGastroenterology\u003c/i\u003e 2007 Apr;132(Issue 4, Supplement 2):A809.\u003c/span\u003e","author":"Sirlin CB, Wolfson T, Gamst A, Middleton M, Hamilton G, Schwimmer J, Lavine JE, Behling C, Grimm PC, Yen T","study_acronym":null,"study_type":null,"abstract":null,"@timestamp":"2024-11-26T23:52:42.993Z","study_name_array":null,"pmcid":null,"publication_year":2007,"study_acronym_array":null,"publication_origin":"Contributing Study","study_type_array":null},"sort":["A multimodality correlation of hepatic steatosis in NAFLD"]},{"_index":"publications_v001","_id":"jf3kapMBC2xkvCSBWxbg","_score":null,"_source":{"affiliation":"Department of Pediatrics and Surgery, University of California, Los Angeles, CA, USA. smcdiarmid@mednet.ucla.edu","request_id_array":null,"doi":"10.1097/SLA.0b013e31821ad86a","request_id":null,"study_name":"Studies of Pediatric Liver Transplantation","author_array":["Mazariegos G","Millis MJ","Martz K","Anand R","McDiarmid SV"],"@version":"1","id":1786,"title":"A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation.","pmid":"21606838","publication_type":"Journal","citation":"\u003cspan\u003eMcDiarmid SV, Anand R, Martz K, Millis MJ, Mazariegos G. A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation. \u003ci\u003eAnn Surg\u003c/i\u003e 2011 Jul;254(1):145-54.\u003c/span\u003e","author":"Mazariegos G, Millis MJ, Martz K, Anand R, McDiarmid SV","study_acronym":"SPLIT","study_type":"Observational","abstract":"The purpose of this study was to identify significant, independent factors that predicted 6 month patient and graft survival after pediatric liver transplantation.","@timestamp":"2024-11-26T23:52:43.012Z","study_name_array":["Studies of Pediatric Liver Transplantation"],"pmcid":"","publication_year":2011,"study_acronym_array":["SPLIT"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation."]},{"_index":"publications_v001","_id":"wf3kapMBC2xkvCSBWxbg","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis","author_array":["Kelly D","Vockley J","He M","Rutledge SL","Goetzman E"],"@version":"1","id":2577,"title":"A new defect in beta-oxidation presenting as sudden liver failure","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eHe M, Rutledge SL, Kelly D, Goetzman E, Vockley J. A new defect in beta-oxidation presenting as sudden liver failure. \u003ci\u003eProceedings of American Society of Human Genetics (ASHG) 55th Annual Meeting\u003c/i\u003e; October 25-29, 2005; Salt Lake City, UT. 2005 Oct.\u003c/span\u003e","author":"Kelly D, Vockley J, He M, Rutledge SL, Goetzman E","study_acronym":"PROBE","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:43.073Z","study_name_array":["A Prospective Database of Infants With Cholestasis"],"pmcid":"","publication_year":2005,"study_acronym_array":["PROBE"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A new defect in beta-oxidation presenting as sudden liver failure"]},{"_index":"publications_v001","_id":"0f3kapMBC2xkvCSBSRKu","_score":null,"_source":{"affiliation":"","request_id_array":null,"doi":null,"request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis","author_array":["Murdoch G","Palmer CA","Kelly DR","Rutledge SL","He M","Vockley J","Watkins PA","Pei Z","Nicholls RD","Majumder N"],"@version":"1","id":2621,"title":"A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency","pmid":"","publication_type":"Conference Presentation","citation":"\u003cspan\u003eHe M, Rutledge SL, Kelly DR, Palmer CA, Murdoch G, Majumder N, Nicholls RD, Pei Z, Watkins PA, Vockley J. A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency. \u003ci\u003eProceedings of International Congress on Inborn Errors of Metabolism\u003c/i\u003e; 2005; 2005.\u003c/span\u003e","author":"Murdoch G, Palmer CA, Kelly DR, Rutledge SL, He M, Vockley J, Watkins PA, Pei Z, Nicholls RD, Majumder N","study_acronym":"PROBE","study_type":"Observational","abstract":null,"@timestamp":"2024-11-26T23:52:43.075Z","study_name_array":["A Prospective Database of Infants With Cholestasis"],"pmcid":"","publication_year":2005,"study_acronym_array":["PROBE"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency"]},{"_index":"publications_v001","_id":"wsLkapMBHb0XhPerT9gh","_score":null,"_source":{"affiliation":"Children's Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, 15213, USA.","request_id_array":null,"doi":"10.1086/519219","request_id":null,"study_name":"A Prospective Database of Infants With Cholestasis","author_array":["Nicholls RD","Pei Z","Watkins PA","Vockley J","Palmer CA","Majumder N","He M","Kelly DR","Rutledge SL","Murdoch G"],"@version":"1","id":2401,"title":"A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency.","pmid":"17564966","publication_type":"Journal","citation":"\u003cspan\u003eHe M, Rutledge SL, Kelly DR, Palmer CA, Murdoch G, Majumder N, Nicholls RD, Pei Z, Watkins PA, Vockley J. A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency. \u003ci\u003eAm J Hum Genet\u003c/i\u003e 2007 Jul;81(1):87-103. Epub 2007 Jun 4.\u003c/span\u003e","author":"Nicholls RD, Pei Z, Watkins PA, Vockley J, Palmer CA, Majumder N, He M, Kelly DR, Rutledge SL, Murdoch G","study_acronym":"PROBE","study_type":"Observational","abstract":"The acyl-CoA dehydrogenases are a family of multimeric flavoenzymes that catalyze the alpha,beta -dehydrogenation of acyl-CoA esters in fatty acid beta -oxidation and amino acid catabolism. Genetic defects have been identified in most of the acyl-CoA dehydrogenases in humans. Acyl-CoA dehydrogenase 9 (ACAD9) is a recently identified acyl-CoA dehydrogenase that demonstrates maximum activity with unsaturated long-chain acyl-CoAs. We now report three cases of ACAD9 deficiency. Patient 1 was a 14-year-old, previously healthy boy who died of a Reye-like episode and cerebellar stroke triggered by a mild viral illness and ingestion of aspirin. Patient 2 was a 10-year-old girl who first presented at age 4 mo with recurrent episodes of acute liver dysfunction and hypoglycemia, with otherwise minor illnesses. Patient 3 was a 4.5-year-old girl who died of cardiomyopathy and whose sibling also died of cardiomyopathy at age 21 mo. Mild chronic neurologic dysfunction was reported in all three patients. Defects in ACAD9 mRNA were identified in the first two patients, and all patients manifested marked defects in ACAD9 protein. Despite a significant overlap of substrate specificity, it appears that ACAD9 and very-long-chain acyl-CoA dehydrogenase are unable to compensate for each other in patients with either deficiency. Studies of the tissue distribution and gene regulation of ACAD9 and very-long-chain acyl-CoA dehydrogenase identify the presence of two independently regulated functional pathways for long-chain fat metabolism, indicating that these two enzymes are likely to be involved in different physiological functions.","@timestamp":"2024-11-26T23:52:43.063Z","study_name_array":["A Prospective Database of Infants With Cholestasis"],"pmcid":"PMC1950923","publication_year":2007,"study_acronym_array":["PROBE"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency."]},{"_index":"publications_v001","_id":"CMLkapMBHb0XhPerWdr7","_score":null,"_source":{"affiliation":"Duke University Medical Center, Durham, North Carolina.","request_id_array":null,"doi":"10.1002/nau.24067","request_id":null,"study_name":"Symptoms of Lower Urinary Tract Dysfunction Phenotyping Study","author_array":["Talaty P","Helfand BT","Kirkali Z","Gillespie BW","Jelovsek JE","Bradley CS","Flynn KE","Griffith JW","Smith AR","Cella D","LURN Study Group","Weinfurt KP"],"@version":"1","id":1054,"title":"A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) questionnaire.","pmid":"31225927","publication_type":"Journal","citation":"\u003cspan\u003eCella D, Smith AR, Griffith JW, Flynn KE, Bradley CS, Gillespie BW, Kirkali Z, Talaty P, Jelovsek JE, Helfand BT, Weinfurt KP, LURN Study Group. A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) questionnaire. \u003ci\u003eNeurourol Urodyn\u003c/i\u003e 2019 Aug;38(6):1751-1759. Epub 2019 Jun 21.\u003c/span\u003e","author":"Talaty P, Helfand BT, Kirkali Z, Gillespie BW, Jelovsek JE, Bradley CS, Flynn KE, Griffith JW, Smith AR, Cella D, LURN Study Group, Weinfurt KP","study_acronym":"LURN","study_type":"Observational","abstract":"To develop a representative, self-report assessment of lower urinary tract symptoms (LUTS) for men and women, the symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29).","@timestamp":"2024-11-26T23:52:42.995Z","study_name_array":["Symptoms of Lower Urinary Tract Dysfunction Phenotyping Study"],"pmcid":"PMC6660359","publication_year":2019,"study_acronym_array":["LURN"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index-29 (LURN SI-29) questionnaire."]},{"_index":"publications_v001","_id":"5cLkapMBHb0XhPerSddo","_score":null,"_source":{"affiliation":"epartment of Electrical, Electronic and System Engineering, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor, Malaysia b Department of Electrical Engineering, Qatar University, Doha, 2713, Qatar c Graduate School of Engineering, University of Hyogo, Hyogo, Japan d P. R. Pote College of Engineering and Management, Kathora Road, Amravati, 444602, India e Department Electrical and Electronic Engineering, Xiamen University Malaysia, Bandar Sunsuria, Sepang, 43900, Selangor, Malaysia ","request_id_array":["23125"],"doi":"10.1016/j.compbiomed.2021.104954","request_id":"23125","study_name":"Diabetes Prevention Program Outcomes Study","author_array":["Arif Sobhan Bhuiyan M","Haque F","Bin Ibne Reaz M","Chowdhury MEH","Hamid Md Ali S","Ashrif A Bakar A","Rahman T","Kobashi S","Dhawale CA"],"@version":"1","id":132,"title":"A nomogram-based diabetic sensorimotor polyneuropathy severity \nprediction using Michigan neuropathy screening instrumentations","pmid":"34715551","publication_type":"Journal","citation":null,"author":"Arif Sobhan Bhuiyan M, Haque F, Bin Ibne Reaz M, Chowdhury MEH, Hamid Md Ali S, Ashrif A Bakar A, Rahman T, Kobashi S, Dhawale CA","study_acronym":"DPPOS","study_type":"Interventional","abstract":"Background: Diabetic Sensorimotor polyneuropathy (DSPN) is one of the major indelible complications in dia\u0002betic patients. Michigan neuropathy screening instrumentation (MNSI) is one of the most common screening \ntechniques used for DSPN, however, it does not provide any direct severity grading system. \nMethod: For designing and modeling the DSPN severity grading systems for MNSI, 19 years of data from \nEpidemiology of Diabetes Interventions and Complications (EDIC) clinical trials were used. Different Machine \nlearning-based feature ranking techniques were investigated to identify the important MNSI features associated \nwith DSPN diagnosis. A multivariable logistic regression-based nomogram was generated and validated for DSPN \nseverity grading using the best performing top-ranked MNSI features. \nResults: Top-10 ranked features from MNSI features: Appearance of Feet (R), Ankle Reflexes (R), Vibration \nperception (L), Vibration perception (R), Appearance of Feet (L), 10-gm filament (L), Ankle Reflexes (L), 10-gm \nfilament (R), Bed Cover Touch, and Ulceration (R) were identified as important features for identifying DSPN by \nMulti-Tree Extreme Gradient Boost model. The nomogram-based prediction model exhibited an accuracy of \n97.95% and 98.84% for the EDIC test set and an independent test set, respectively. A DSPN severity score \ntechnique was generated for MNSI from the DSPN severity prediction model. DSPN patients were stratified into \nfour severity levels: absent, mild, moderate, and severe using the cut-off values of 17.6, 19.1, 20.5 for the DSPN \nprobability less than 50%, 75%–90%, and above 90%, respectively. \nConclusions: The findings of this work provide a machine learning-based MNSI severity grading system which has \nthe potential to be used as a secondary decision support system by health professionals in clinical applications \nand large clinical trials to identify high-risk DSPN patients.","@timestamp":"2024-11-26T23:52:43.098Z","study_name_array":["Diabetes Prevention Program Outcomes Study"],"pmcid":null,"publication_year":2021,"study_acronym_array":["DPPOS"],"publication_origin":"Secondary Research","study_type_array":["Interventional"]},"sort":["A nomogram-based diabetic sensorimotor polyneuropathy severity \nprediction using Michigan neuropathy screening instrumentations"]},{"_index":"publications_v001","_id":"HP3kapMBC2xkvCSBTRQW","_score":null,"_source":{"affiliation":"Department of Statistics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. yuzhang@stat.psu.edu","request_id_array":null,"doi":"10.1002/gepi.20661","request_id":null,"study_name":"Inflammatory Bowel Disease Genetics","author_array":["Zhang Y"],"@version":"1","id":1708,"title":"A novel bayesian graphical model for genome-wide multi-SNP association mapping.","pmid":"22127647","publication_type":"Journal","citation":"\u003cspan\u003eZhang Y. A novel bayesian graphical model for genome-wide multi-SNP association mapping. \u003ci\u003eGenet Epidemiol\u003c/i\u003e 2012 Jan;36(1):36-47. Epub 2011 Nov 29.\u003c/span\u003e","author":"Zhang Y","study_acronym":"IBD","study_type":"Observational","abstract":"Most disease association mapping algorithms are based on hypothesis testing procedures that test one variant at a time. Those methods lose power when the disease mutations are jointly tagged by multiple variants, or when gene-gene interaction exist. Nearby variants are also correlated, for which procedures ignoring the dependence between variants will inevitably produce redundant results. With a large number of variants genotyped in current genome-wide disease association studies, simultaneous multivariant association mapping algorithms are strongly desired. We present a novel Bayesian method for automatic detection of multivariant joint association in genome-wide case-control studies. Our method has improved power and specificity over existing tools. We fit a joint probabilistic model to the entire data and identify disease variants simultaneously. The method dynamically accounts for the strong linkage disequilibrium (LD) between variants. As a result, only the primary disease variants will be identified, with all secondary associations due to LD effects filtered out. Our method better pinpoints the disease variants with improved resolution. The method is also computationally efficient for genome-wide studies. When applied to a real data set of inflammatory bowel disease (IBD) containing 401,473 variants in 4,720 individuals, our method detected all previously reported IBD loci in the same data, and recovered two missed loci. We further detected two novel interchromosome interactions. The first is between STAT3 and PARD6G, and the second is between DLG5 and an intergenic region at 5p14. We further validated the two interactions in an independent study.","@timestamp":"2024-11-26T23:52:43.009Z","study_name_array":["Inflammatory Bowel Disease Genetics"],"pmcid":"PMC3337957","publication_year":2012,"study_acronym_array":["IBD"],"publication_origin":"Contributing Study","study_type_array":["Observational"]},"sort":["A novel bayesian graphical model for genome-wide multi-SNP association mapping."]}]},"aggregations":{"filters#publication_year":{"meta":{},"buckets":[{"doc_count":2066,"sterms#publication_year":{"doc_count_error_upper_bound":0,"sum_other_doc_count":0,"buckets":[]}}]},"filters#study_acronym_array":{"meta":{},"buckets":[{"doc_count":2066,"sterms#study_acronym_array":{"doc_count_error_upper_bound":0,"sum_other_doc_count":0,"buckets":[{"key":"A2ALL","doc_count":73},{"key":"AALF","doc_count":70},{"key":"AASK Cohort","doc_count":7},{"key":"AASK 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