CINXE.COM

NIDDK Central Repository

<!DOCTYPE html><html><head><meta charSet="utf-8"/><meta name="viewport" content="width=device-width"/><title>NIDDK Central Repository</title><meta name="next-head-count" content="3"/><link data-next-font="size-adjust" rel="preconnect" href="/" crossorigin="anonymous"/><link rel="preload" href="/_next/static/css/93e60cbdc9b67ef2.css" as="style"/><link rel="stylesheet" href="/_next/static/css/93e60cbdc9b67ef2.css" data-n-g=""/><link rel="preload" href="/_next/static/css/6f66443a0b2033ad.css" as="style"/><link rel="stylesheet" href="/_next/static/css/6f66443a0b2033ad.css" data-n-p=""/><noscript data-n-css=""></noscript><script defer="" nomodule="" src="/_next/static/chunks/polyfills-42372ed130431b0a.js"></script><script src="/_next/static/chunks/webpack-dcf4136cb4ed4a3e.js" defer=""></script><script src="/_next/static/chunks/framework-e952fed463eb8e34.js" defer=""></script><script src="/_next/static/chunks/main-97bba83dfe7e8d62.js" defer=""></script><script src="/_next/static/chunks/pages/_app-daedab1e29253550.js" defer=""></script><script src="/_next/static/chunks/238-4af308b231a3ae46.js" defer=""></script><script src="/_next/static/chunks/pages/publications/%5BpublicationId%5D-f1ac5bf81884c184.js" defer=""></script><script src="/_next/static/4IwPCL7p9Vb_-_lB6rNWm/_buildManifest.js" defer=""></script><script src="/_next/static/4IwPCL7p9Vb_-_lB6rNWm/_ssgManifest.js" defer=""></script></head><body><div id="__next"><div class="CoreLayout_coreLayout__AbvUo "><div class="CoreLayout_container__C25fM"><div class="GovBanner_govBanner__l6GMd"><div class="GovBanner_bannerHeader__OJ1DM"><img src="/images/us_flag_small.png"/><p>An official website of the United States government</p><p><button><a>Here&#x27;s how you would know <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="10" height="10" fill="currentColor" class="bi bi-chevron-down"><path fill-rule="evenodd" d="M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708"></path></svg></a></button></p></div></div><div class="PageHeader_logoContainer__lq_Xl row"><div class="PageHeader_content__Yo7eT col"><a href="https://www.niddk.nih.gov"><div><svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="300px" height="100px" viewBox="-528 662 578 130" enable-background="new -528 662 578 130" xml:space="preserve"><title>NIH: National Institute of Diabetes and Digestive and Kidney Diseases</title><g><g><path fill="#646569" d="M-383.6,698.1v58h-10.1l0,0v-26.3h-26.6v26.3h-10.1v-58h10.1v23.2h26.6v-23.2l0,0H-383.6z M-440.6,756.4 L-440.6,756.4h-10.1v-58h10.1V756.4z M-460.7,756.4L-460.7,756.4h-10.8l-26.6-42.8h-0.3v42.8h-9.8l0,0v-58l0,0h10.8l0,0l26.6,42.8 h0.3v-42.8h9.8V756.4z M-347.7,727l-35.9-65h-132.6c-6.7,0-11.9,5.4-11.9,11.9v106c0,6.7,5.4,11.9,11.9,11.9h132.3L-347.7,727z"></path><path fill="#71963E" d="M-374.5,792l36.1-65l-35.9-65h9c4.9,0,10.8,3.6,13.2,7.7l31.5,57.3l-31.7,57.3c-2.3,4.4-8.3,7.7-13.4,7.7 H-374.5z"></path></g><g><path fill="#616365" d="M-305,674.6h4.4l10.8,17.5l0,0v-17.5h3.9v24h-4.4l-10.8-17.5l0,0v17.5h-3.9 C-305,698.6-305,674.6-305,674.6z"></path><path fill="#616365" d="M-266.6,694.8c0,0.3,0,0.8,0.3,1c0,0.3,0.3,0.3,0.8,0.3h1v2.6c-0.3,0-0.5,0-0.5,0.3c-0.3,0-0.5,0-0.8,0.3 h-1.3c-0.8,0-1.5-0.3-2.1-0.5c-0.5-0.3-1-1-1-1.5c-0.8,0.8-1.8,1.3-2.8,1.5c-1,0.3-2.1,0.5-3.1,0.5c-0.8,0-1.5,0-2.3-0.3 c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.5-1-1-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.5-2.6c0.3-0.5,1-1.3,1.5-1.5 c0.5-0.5,1.3-0.8,2.1-0.8c0.8-0.3,1.5-0.3,2.3-0.3c0.8-0.3,1.3-0.3,2.1-0.3c0.5,0,1,0,1.5-0.3c0.3,0,0.8-0.3,1-0.5 c0.3-0.3,0.5-0.8,0.5-1.3c0-0.5,0-0.8-0.3-1.3l-0.8-0.8c-0.3-0.3-0.8-0.3-1-0.3h-1.3c-1,0-1.8,0.3-2.6,0.8s-1.3,1.3-1.3,2.1h-3.9 c0-1,0.3-2.1,0.8-2.8c0.5-0.8,1-1.3,1.8-1.8c0.8-0.5,1.5-0.8,2.6-1c1-0.3,1.8-0.3,2.8-0.3c0.8,0,1.8,0,2.6,0.3l2.3,0.8 c0.5,0.3,1.3,1,1.5,1.5c0.5,0.8,0.8,1.5,0.5,2.3V694.8L-266.6,694.8L-266.6,694.8z M-270.5,689.9c-0.8,0.3-1.3,0.5-2.1,0.8 c-0.8,0-1.8,0.3-2.6,0.3s-0.8,0.3-1.3,0.3s-0.8,0.3-1,0.5l-0.8,0.8c-0.3,0.5-0.3,0.8-0.3,1.3c0,0.3,0,0.8,0.3,1l0.8,0.8 c0.3,0.3,0.8,0.3,1,0.3h1c0.5,0,0.8,0,1.3-0.3c0.5,0,1-0.3,1.3-0.5c0.5-0.3,0.8-0.5,1-1c0.3-0.5,0.5-1,0.5-1.5v-2.6L-270.5,689.9 L-270.5,689.9z"></path><path fill="#616365" d="M-264.3,681.3h2.8v-5.2h3.9v5.2h3.4v2.8h-3.4v10.3c0,0.3,0,0.5,0.3,0.8c0,0.3,0.3,0.5,0.5,0.5 c0.3,0.3,0.8,0.3,1,0.3h1.5v2.8c-0.5,0-0.8,0-1.3,0.3h-1.3c-0.8,0-1.5,0-2.3-0.3l-1.5-0.8c-0.3-0.5-0.5-0.8-0.8-1.3 c0-0.5-0.3-1.3-0.3-1.8v-10.3h-2.8v-3.4L-264.3,681.3L-264.3,681.3z"></path><path fill="#616365" d="M-251.4,674.6h3.9v3.6h-3.9V674.6z M-251.4,681.3h3.9v17.3h-3.9V681.3z"></path><path fill="#616365" d="M-235.4,699.1c-1.3,0-2.6-0.3-3.6-0.8c-2.1-0.8-3.9-2.6-4.6-4.6c-0.5-1-0.5-2.3-0.5-3.6s0.3-2.3,0.5-3.6 c0.5-1,1-2.1,1.8-2.8c0.8-0.8,1.8-1.5,2.8-1.8c2.3-1,4.9-1,7.2,0c2.1,0.8,3.9,2.6,4.6,4.6c0.5,1,0.5,2.3,0.5,3.6s-0.3,2.3-0.5,3.6 c-0.5,1-1,2.1-1.8,2.8c-0.8,0.8-1.8,1.5-2.8,1.8C-232.8,698.9-234.1,699.1-235.4,699.1z M-235.4,696c0.8,0,1.5-0.3,2.3-0.5 c0.5-0.3,1-0.8,1.5-1.3c0.5-0.5,0.8-1.3,0.8-2.1c0.3-1.5,0.3-3.1,0-4.6c-0.3-0.8-0.5-1.3-0.8-2.1c-0.5-0.5-1-1-1.5-1.3 c-0.8-0.3-1.5-0.5-2.3-0.5c-0.8,0-1.5,0.3-2.3,0.5c-0.5,0.3-1,0.8-1.5,1.3s-0.8,1.3-0.8,2.1c-0.3,1.5-0.3,3.1,0,4.6 c0.3,0.8,0.5,1.3,0.8,2.1c0.5,0.5,1,1,1.5,1.3C-236.9,696-236.2,696-235.4,696z"></path><path fill="#616365" d="M-223.3,681.3h3.6v2.6l0,0c0.5-1,1.3-1.8,2.3-2.3c1-0.5,2.1-0.8,3.1-0.8c2.8-0.3,5.7,1.8,5.9,4.9 c0,0.3,0,0.8,0,1v11.9h-3.9v-10.8c0-1-0.3-2.1-0.8-3.1c-0.5-0.8-1.5-1.3-2.6-1c-0.5,0-1.3,0-1.8,0.3s-1,0.5-1.3,1 c-0.3,0.5-0.5,1-0.8,1.5c-0.3,0.5-0.3,1.3-0.3,1.8v10.3h-3.6V681.3z"></path><path fill="#616365" d="M-189.5,694.8c0,0.3,0,0.8,0.3,1c0,0.3,0.3,0.3,0.8,0.3h1v2.6c-0.3,0-0.5,0-0.5,0.3c-0.3,0-0.5,0-0.8,0.3 h-1.3c-0.8,0-1.5-0.3-2.1-0.5c-0.5-0.3-1-1-1-1.5c-0.8,0.8-1.8,1.3-2.8,1.5s-2.1,0.5-3.1,0.5c-0.8,0-1.5,0-2.3-0.3 c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.5-1-1-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.5-2.6c0.3-0.5,1-1.3,1.5-1.5 c0.5-0.5,1.3-0.8,2.1-0.8c0.8-0.3,1.5-0.3,2.3-0.3c0.8-0.3,1.3-0.3,2.1-0.3c0.5,0,1,0,1.5-0.3c0.3,0,0.8-0.3,1-0.5 c0.3-0.3,0.5-0.8,0.5-1.3c0-0.5,0-0.8-0.3-1.3l-0.8-0.8c-0.3-0.3-0.8-0.3-1-0.3h-1.3c-1,0-1.8,0.3-2.6,0.8 c-0.8,0.5-1.3,1.3-1.3,2.1h-3.9c0-1,0.3-2.1,0.8-2.8c0.5-0.8,1-1.3,1.8-1.8c0.8-0.5,1.5-0.8,2.6-1c1-0.3,1.8-0.3,2.8-0.3 c0.8,0,1.8,0,2.6,0.3l2.3,0.8c0.5,0.3,1.3,1,1.5,1.5c0.5,0.8,0.8,1.5,0.5,2.3V694.8L-189.5,694.8L-189.5,694.8z M-193.1,689.9 c-0.8,0.3-1.3,0.5-2.1,0.8c-0.8,0-1.8,0.3-2.6,0.3s-0.8,0.3-1.3,0.3c-0.5,0-0.8,0.3-1,0.5l-0.8,0.8c-0.3,0.5-0.3,0.8-0.3,1.3 c0,0.3,0,0.8,0.3,1l0.8,0.8c0.3,0.3,0.8,0.3,1,0.3h1c0.5,0,0.8,0,1.3-0.3c0.5,0,1-0.3,1.3-0.5c0.5-0.3,0.8-0.5,1-1 c0.3-0.5,0.5-1,0.5-1.5v-2.6L-193.1,689.9L-193.1,689.9z"></path><path fill="#616365" d="M-185.1,674.6h3.9v24h-3.9V674.6z"></path><path fill="#616365" d="M-167.3,674.6h4.1v24h-4.1V674.6z"></path><path fill="#616365" d="M-158.5,681.3h3.6v2.6l0,0c0.5-1,1.3-1.8,2.3-2.3c1-0.5,2.1-0.8,3.1-0.8c2.8-0.3,5.7,1.8,5.9,4.9 c0,0.3,0,0.8,0,1v11.9h-3.9v-10.8c0-1-0.3-2.1-0.8-3.1c-0.5-0.8-1.5-1.3-2.6-1c-0.5,0-1.3,0-1.8,0.3c-0.5,0.3-1,0.5-1.3,1 c-0.3,0.5-0.5,1-0.8,1.5c-0.3,0.5-0.3,1.3-0.3,1.8v10.3h-3.9v-17.3L-158.5,681.3L-158.5,681.3z"></path><path fill="#616365" d="M-136.3,693c0,1,0.5,1.8,1.3,2.3c0.8,0.5,1.5,0.8,2.6,0.8h1.3c0.5,0,0.8-0.3,1.3-0.3s0.8-0.3,1-0.8 c0.3-0.5,0.3-0.8,0.3-1.3c0-0.5-0.3-1-0.5-1.3c-0.5-0.3-0.8-0.5-1.3-0.8c-0.5-0.3-1.3-0.3-1.8-0.5c-0.8-0.3-1.3-0.3-2.1-0.5 c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.5-1-1-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.8-2.3 c0.5-0.5,1-1,1.8-1.5c0.8-0.5,1.5-0.8,2.3-0.8c1.8-0.3,3.4-0.3,5.2,0c0.8,0.3,1.5,0.5,2.3,1c1.5,0.8,2.3,2.6,2.3,4.1h-3.9 c0-0.8-0.5-1.5-1.3-1.8c-0.8-0.3-1.5-0.5-2.3-0.5h-1c-0.3,0-0.8,0-1,0.3c-0.3,0-0.5,0.3-0.8,0.5c-0.3,0.3-0.3,0.8-0.3,1 c0,0.5,0.3,0.8,0.5,1c0.5,0.3,0.8,0.5,1.3,0.8c0.5,0.3,1.3,0.3,1.8,0.5c0.8,0.3,1.3,0.3,2.1,0.5c0.8,0.3,1.3,0.3,2.1,0.5 c0.8,0.3,1.3,0.5,1.8,1c0.5,0.3,1,0.8,1.3,1.5c0.3,0.5,0.5,1.3,0.5,2.1c0,1-0.3,1.8-0.8,2.6c-0.5,0.8-1,1.3-1.8,1.8 c-0.8,0.5-1.5,0.8-2.6,1c-1,0.3-1.8,0.3-2.8,0.3c-1,0-2.1,0-3.1-0.3c-0.8-0.3-1.5-0.5-2.3-1c-0.8-0.5-1.3-1-1.5-1.8 c-0.5-0.8-0.5-1.8-0.5-2.6h3.6L-136.3,693L-136.3,693z"></path><path fill="#616365" d="M-123.7,681.3h2.8v-5.2h3.9v5.2h3.4v2.8h-3.4v10.3c0,0.3,0,0.5,0.3,0.8c0,0.3,0.3,0.5,0.5,0.5 c0.3,0,0.8,0.3,1,0.3h1.5v2.8c-0.5,0-0.8,0-1.3,0.3h-1.3c-0.8,0-1.5,0-2.3-0.3l-1.5-0.8c-0.3-0.5-0.5-0.8-0.8-1.3 c0-0.5-0.3-1.3-0.3-1.8v-10.3h-2.8v-3.4L-123.7,681.3L-123.7,681.3z"></path><path fill="#616365" d="M-110.5,674.6h3.9v3.6h-3.9V674.6z M-110.5,681.3h3.9v17.3h-3.9V681.3z"></path><path fill="#616365" d="M-104.4,681.3h2.8v-5.2h3.9v5.2h3.4v2.8h-3.4v10.3c0,0.3,0,0.5,0.3,0.8c0,0.3,0.3,0.5,0.5,0.5 c0.3,0,0.8,0.3,1,0.3h1.5v2.8c-0.5,0-0.8,0-1.3,0.3h-1.3c-0.8,0-1.5,0-2.3-0.3l-1.5-0.8c-0.3-0.5-0.5-0.8-0.8-1.3 c0-0.5-0.3-1.3-0.3-1.8v-10.3h-2.8v-3.4L-104.4,681.3L-104.4,681.3z"></path><path fill="#616365" d="M-76,698.6h-3.9v-2.3l0,0c-0.5,0.8-1.3,1.5-2.1,2.1c-0.8,0.5-1.8,0.8-2.8,0.8c-1.8,0.3-3.6-0.5-4.9-1.8 c-1.3-1.5-1.8-3.4-1.5-5.2v-11.1h3.9v10.6c-0.3,1,0.3,2.3,0.8,3.1c0.5,0.5,1.5,1,2.3,1c0.8,0,1.3,0,2.1-0.3c0.5-0.3,1-0.5,1.3-1 l0.8-1.5c0.3-0.5,0.3-1.3,0.3-1.8v-10.1h3.9V698.6L-76,698.6L-76,698.6z"></path><path fill="#616365" d="M-73.7,681.3h2.8v-5.2h3.9v5.2h3.4v2.8H-67v10.3c0,0.3,0,0.5,0.3,0.8c0,0.3,0.3,0.5,0.5,0.5 c0.3,0,0.8,0.3,1,0.3h1.5v2.8c-0.5,0-0.8,0-1.3,0.3h-1.3c-0.8,0-1.5,0-2.3-0.3l-1.5-0.8c-0.3-0.5-0.5-0.8-0.8-1.3 c0-0.5-0.3-1.3-0.3-1.8v-10.3h-2.8v-3.4L-73.7,681.3L-73.7,681.3z"></path><path fill="#616365" d="M-57.9,690.9c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.5,0.5,1,0.8,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.3,1 c-0.8,0.3-1.8,0.3-2.6,0.3c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6 s0.3-2.3,0.5-3.6c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8c1.3,0,2.6,0.3,3.6,0.8 c1,0.5,2.1,1.3,2.6,2.3c0.8,1,1.3,2.1,1.5,3.4c0.3,1.3,0.5,2.6,0.3,3.9L-57.9,690.9L-57.9,690.9z M-48.9,688.3 c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5 c-0.3,0.5-0.3,1.3-0.5,1.8H-48.9z"></path><path fill="#616365" d="M-24.9,699.1c-1.3,0-2.6-0.3-3.6-0.8c-2.1-0.8-3.9-2.6-4.6-4.6c-0.5-1-0.5-2.3-0.5-3.6s0.3-2.3,0.5-3.6 c0.5-1,1-2.1,1.8-2.8c0.8-0.8,1.8-1.5,2.8-1.8c2.3-1,4.9-1,7.2,0c2.1,0.8,3.9,2.6,4.6,4.6c0.5,1,0.5,2.3,0.5,3.6s-0.3,2.3-0.5,3.6 c-0.5,1-1,2.1-1.8,2.8c-0.8,0.8-1.8,1.5-2.8,1.8C-22.3,699.1-23.6,699.4-24.9,699.1z M-24.9,696c0.8,0,1.5-0.3,2.3-0.5 c0.5-0.3,1-0.8,1.5-1.3c0.5-0.5,0.8-1.3,0.8-2.1c0.3-1.5,0.3-3.1,0-4.6c-0.3-0.8-0.5-1.3-0.8-2.1c-0.5-0.5-1-1-1.5-1.3 c-0.8-0.3-1.5-0.5-2.3-0.5s-1.5,0.3-2.3,0.5c-0.5,0.3-1,0.8-1.5,1.3c-0.5,0.5-0.8,1.3-0.8,2.1c-0.3,1.5-0.3,3.1,0,4.6 c0.3,0.8,0.5,1.3,0.8,2.1c0.5,0.5,1,1,1.5,1.3C-26.5,696-25.7,696-24.9,696z"></path><path fill="#616365" d="M-14.6,681.3h2.8v-1.5c0-0.8,0.3-1.8,0.5-2.6c0-0.5,0.5-1.3,1-1.5l1.5-0.8c0.5,0,1.3-0.3,1.8-0.3 c0.8,0,1.8,0,2.6,0.3v3.1c-0.3,0-0.5,0-0.8-0.3h-1c-0.5,0-1,0-1.3,0.3c-0.3,0.5-0.5,1-0.5,1.5v1.8h3.4v2.8h-3.4v14.4h-3.9v-14.4 h-2.8L-14.6,681.3L-14.6,681.3L-14.6,681.3z"></path><path fill="#616365" d="M-304.8,715.1h9.8c1.5,0,3.4,0.3,4.6,1c1.3,0.8,2.3,1.5,3.4,2.6s1.5,2.6,1.8,3.9c0.5,1.5,0.5,3.1,0.5,4.6 s-0.3,3.1-0.5,4.6c-0.3,1.3-1,2.8-1.8,3.9c-0.8,1-2.1,2.1-3.4,2.6c-1.5,0.5-3.1,1-4.6,1h-9.8V715.1L-304.8,715.1z M-300.6,735.8 h4.1c1.3,0,2.8-0.3,4.1-0.8c1-0.3,1.8-1,2.3-1.8c0.5-0.8,1-1.8,1.3-2.8c0.3-2.3,0.3-4.4,0-6.7c-0.3-1-0.5-2.1-1.3-2.8 c-0.8-0.8-1.5-1.3-2.3-1.8c-1.3-0.5-2.8-0.8-4.1-0.8h-4.1V735.8L-300.6,735.8z"></path><path fill="#616365" d="M-281,715.1h3.9v3.6h-3.9V715.1z M-281,721.8h3.9v17.3h-3.9V721.8z"></path><path fill="#616365" d="M-258.6,735.3c0,0.3,0,0.8,0.3,1c0,0.3,0.3,0.3,0.8,0.3h1v2.6c-0.3,0-0.5,0-0.5,0.3 c-0.3,0.3-0.5,0-0.8,0.3h-1.3c-0.8,0-1.5-0.3-2.1-0.5c-0.5-0.3-1-1-1-1.5c-0.8,0.8-1.8,1.3-2.8,1.5c-1,0.3-2.1,0.5-3.1,0.5 c-0.8,0-1.5,0-2.3-0.3s-1.3-0.5-1.8-1c-0.5-0.5-1-1-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.5-2.6 c0.3-0.5,1-1.3,1.5-1.5c0.5-0.5,1.3-0.8,2.1-0.8c0.8-0.3,1.5-0.3,2.3-0.3c0.8-0.3,1.3-0.3,2.1-0.3c0.5,0,1,0,1.5-0.3 c0.3,0,0.8-0.3,1-0.5c0.3-0.3,0.5-0.8,0.5-1.3c0-0.5,0-0.8-0.3-1.3l-0.8-0.8c-0.3-0.3-0.8-0.3-1-0.3h-1.3c-1,0-1.8,0.3-2.6,0.8 c-0.8,0.5-1.3,1.3-1.3,2.1h-3.9c0-1,0.3-2.1,0.8-2.8c0.5-0.8,1-1.3,1.8-1.8c0.8-0.5,1.5-0.8,2.6-1c1-0.3,1.8-0.3,2.8-0.3 c0.8,0,1.8,0,2.6,0.3l2.3,0.8c0.5,0.3,1.3,1,1.5,1.5c0.5,0.8,0.8,1.5,0.5,2.3V735.3L-258.6,735.3L-258.6,735.3z M-262.5,730.4 c-0.8,0.3-1.3,0.5-2.1,0.8c-0.8,0-1.8,0.3-2.6,0.3s-0.8,0.3-1.3,0.3s-0.8,0.3-1,0.5l-0.8,0.8c-0.3,0.5-0.3,0.8-0.3,1.3 c0,0.3,0,0.8,0.3,1l0.8,0.8c0.3,0.3,0.8,0.3,1,0.3h1c0.5,0,0.8,0,1.3-0.3c0.5,0,1-0.3,1.3-0.5c0.5-0.3,0.8-0.5,1-1 c0.3-0.5,0.5-1,0.5-1.5v-2.6L-262.5,730.4L-262.5,730.4z"></path><path fill="#616365" d="M-254.5,715.1h3.9v8.8l0,0c0.3-0.5,0.5-0.8,1-1c0.5-0.3,0.8-0.5,1.3-0.8s1-0.5,1.5-0.5 c0.5,0,1-0.3,1.5-0.3c1.3,0,2.6,0.3,3.6,0.8c1,0.5,1.8,1.3,2.6,2.1c0.8,0.8,1.3,1.8,1.5,2.8c0.3,1.3,0.5,2.3,0.5,3.6 c0,1-0.3,2.3-0.5,3.4c-0.3,1-0.8,2.1-1.3,2.8c-0.5,0.8-1.3,1.5-2.3,2.1c-1,0.5-2.3,0.8-3.4,0.8h-1.8c-0.5,0-1.3-0.3-1.8-0.5 c-0.5-0.3-1-0.5-1.5-0.8s-0.8-0.8-1-1.3l0,0v2.3h-3.9V715.1z M-241.1,730.4c0-0.8,0-1.5-0.3-2.3c-0.3-0.8-0.5-1.5-1-2.1 c-0.5-0.5-1-1-1.5-1.3c-0.5-0.3-1.3-0.5-2.1-0.5c-1.3,0-2.8,0.5-3.6,1.5c-0.8,1.3-1.3,2.8-1.3,4.4c0,0.8,0,1.5,0.3,2.3 c0.3,0.8,0.5,1.3,1,1.8s1,1,1.5,1.3s1.3,0.5,2.1,0.5c0.8,0,1.5-0.3,2.3-0.5c0.5-0.3,1-0.8,1.5-1.3c0.5-0.5,0.8-1.3,0.8-2.1 C-241.3,731.4-241.1,731.1-241.1,730.4z"></path><path fill="#616365" d="M-231,731.4c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.5,0.5,1,0.8,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-1.5,0.8-3.1,1.3-4.9,1.5 c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6s0.3-2.3,0.5-3.6 c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8c1.3,0,2.6,0.3,3.6,0.8c1,0.5,2.1,1.3,2.6,2.3 c0.8,1,1.3,2.1,1.5,3.4c0.3,1.3,0.5,2.6,0.3,3.9H-231V731.4L-231,731.4z M-221.7,728.8c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5 c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5c-0.3,0.5-0.3,1.3-0.3,1.8H-221.7z"></path><path fill="#616365" d="M-216.8,721.8h2.8v-5.2h3.9v5.2h3.4v2.8h-3.4V735c0,0.3,0,0.5,0.3,0.8c0,0.3,0.3,0.5,0.5,0.5 c0.3,0.3,0.8,0.3,1,0.3h1.5v2.8c-0.5,0-0.8,0-1.3,0.3h-1.3c-0.8,0-1.5,0-2.3-0.3l-1.5-0.8c-0.3-0.5-0.5-0.8-0.8-1.3 c0-0.5-0.3-1.3-0.3-1.8v-10.3h-2.8v-3.4L-216.8,721.8L-216.8,721.8z"></path><path fill="#616365" d="M-200.8,731.4c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.5,0.5,1,0.8,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-1.5,0.8-3.1,1.3-4.9,1.5 c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6s0.3-2.3,0.5-3.6 c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8c1.3,0,2.6,0.3,3.6,0.8c1,0.5,2.1,1.3,2.6,2.3 c0.8,1,1.3,2.1,1.5,3.4c0.3,1.3,0.5,2.6,0.3,3.9h-12.6V731.4L-200.8,731.4z M-192.1,728.8c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5 c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5c-0.3,0.5-0.3,1.3-0.3,1.8H-192.1z"></path><path fill="#616365" d="M-182.2,733.4c0,1,0.5,1.8,1.3,2.3c0.8,0.5,1.5,0.8,2.6,0.8h1.3c0.5,0,0.8-0.3,1.3-0.3 c0.5-0.3,0.8-0.5,1-0.8c0.3-0.5,0.3-0.8,0.3-1.3c0-0.5-0.3-1-0.5-1.3c-0.5-0.3-0.8-0.5-1.3-0.8c-0.5-0.3-1.3-0.3-1.8-0.5 c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.3-1-0.8-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3 c0-0.8,0.3-1.8,0.8-2.3c0.5-0.5,1-1,1.8-1.5c0.8-0.5,1.5-0.8,2.3-0.8c1.8-0.3,3.4-0.3,5.2,0c0.8,0.3,1.5,0.5,2.3,1 c1.5,0.8,2.3,2.6,2.3,4.1h-3.9c0-0.8-0.5-1.5-1.3-1.8c-0.8-0.3-1.5-0.5-2.3-0.5h-1c-0.3,0-0.8,0-1,0.3c-0.3,0-0.5,0.3-0.8,0.5 c-0.3,0.3-0.3,0.8-0.3,1c0,0.5,0.3,0.8,0.5,1c0.5,0.3,0.8,0.5,1.3,0.8c0.5,0.3,1.3,0.3,1.8,0.5c0.8,0.3,1.3,0.3,2.1,0.5 c0.8,0.3,1.3,0.3,2.1,0.5c0.8,0.3,1.3,0.5,1.8,1c0.5,0.3,1,0.8,1.3,1.5c0.3,0.5,0.5,1.3,0.5,2.1c0,1-0.3,1.8-0.8,2.6 c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.6,1c-1,0.3-1.8,0.3-2.8,0.3s-2.1,0-3.1-0.3c-0.8-0.3-1.5-0.5-2.3-1 c-0.8-0.5-1.3-1-1.5-1.8c-0.5-0.8-0.5-1.8-0.5-2.6h3.6V733.4L-182.2,733.4z"></path><path fill="#616365" d="M-144.1,735.3c0,0.3,0,0.8,0.3,1c0,0.3,0.3,0.3,0.8,0.3h1v2.6c-0.3,0-0.5,0-0.5,0.3 c-0.3,0.3-0.5,0-0.8,0.3h-1.3c-0.8,0-1.5-0.3-2.1-0.5c-0.5-0.3-1-1-1-1.5c-0.8,0.8-1.8,1.3-2.8,1.5c-1,0.3-2.1,0.5-3.1,0.5 c-0.8,0-1.5,0-2.3-0.3c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.5-1-1-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.5-2.6 c0.3-0.5,1-1.3,1.5-1.5c0.5-0.5,1.3-0.8,2.1-0.8c0.8-0.3,1.5-0.3,2.3-0.3c0.8-0.3,1.3-0.3,2.1-0.3c0.5,0,1,0,1.5-0.3 c0.3,0,0.8-0.3,1-0.5c0.3-0.3,0.5-0.8,0.5-1.3c0-0.5,0-0.8-0.3-1.3l-0.8-0.8c-0.3-0.3-0.8-0.3-1-0.3h-1.3c-1,0-1.8,0.3-2.6,0.8 c-0.8,0.5-1.3,1.3-1.3,2.1h-3.6c0-1,0.3-2.1,0.8-2.8c0.5-0.8,1-1.3,1.8-1.8c0.8-0.5,1.5-0.8,2.6-1c1-0.3,1.8-0.3,2.8-0.3 c0.8,0,1.8,0,2.6,0.3l2.3,0.8c0.5,0.3,1.3,1,1.5,1.5c0.5,0.8,0.8,1.5,0.5,2.3v8.8L-144.1,735.3L-144.1,735.3z M-147.9,730.4 c-0.8,0.3-1.3,0.5-2.1,0.8c-0.8,0-1.8,0.3-2.6,0.3s-0.8,0.3-1.3,0.3c-0.5,0-0.8,0.3-1,0.5l-0.8,0.8c-0.3,0.5-0.3,0.8-0.3,1.3 c0,0.3,0,0.8,0.3,1l0.8,0.8c0.3,0.3,0.8,0.3,1,0.3h1c0.5,0,0.8,0,1.3-0.3c0.5,0,1-0.3,1.3-0.5c0.5-0.3,0.8-0.5,1-1 c0.3-0.5,0.5-1,0.5-1.5v-2.6L-147.9,730.4L-147.9,730.4z"></path><path fill="#616365" d="M-139.9,721.8h3.6v2.6l0,0c0.5-1,1.3-1.8,2.3-2.3c1-0.5,2.1-0.8,3.1-0.8c2.8-0.3,5.7,1.8,5.9,4.9 c0,0.3,0,0.8,0,1v11.9h-3.9v-10.8c0-1-0.3-2.1-0.8-3.1c-0.5-0.8-1.5-1.3-2.6-1c-0.5,0-1.3,0-1.8,0.3s-1,0.5-1.3,1 c-0.3,0.5-0.5,1-0.8,1.5c-0.3,0.5-0.3,1.3-0.3,1.8v10.3h-3.9v-17.3L-139.9,721.8L-139.9,721.8z"></path><path fill="#616365" d="M-104.4,739.1h-3.6v-2.3l0,0c-0.5,1-1.3,1.8-2.3,2.1c-1,0.5-2.1,0.8-3.1,0.8c-1.3,0-2.6-0.3-3.6-0.8 c-1-0.5-1.8-1.3-2.6-2.1c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6c0-1.3,0.3-2.8,0.5-4.1c0.5-1,1-2.1,1.8-2.8 c0.5-0.8,1.5-1.3,2.3-1.5c1-0.3,1.8-0.5,2.8-0.5c0.5,0,1,0,1.5,0.3c0.5,0,1,0.3,1.5,0.5l1.5,0.8c0.5,0.3,0.8,0.8,1,1.3l0,0v-8.8 h3.9v23.7H-104.4z M-117.8,730.6c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1.3,0.8,1.8c0.5,0.5,1,1,1.5,1.3s1.3,0.5,2.1,0.5 c0.8,0,1.5-0.3,2.3-0.5c0.5-0.3,1-0.8,1.5-1.3c0.5-0.5,0.8-1.3,0.8-2.1c0.3-0.8,0.3-1.5,0.3-2.3c0-1.5-0.5-3.1-1.3-4.4 c-0.8-1-2.3-1.5-3.6-1.5c-0.8,0-1.5,0.3-2.3,0.5c-0.8,0.3-1.3,0.8-1.5,1.5c-0.5,0.5-0.8,1.3-0.8,2.1 C-117.5,729.1-117.5,729.8-117.8,730.6z"></path><path fill="#616365" d="M-90.2,715.1h9.8c1.5,0,3.4,0.3,4.6,1c1.3,0.5,2.3,1.5,3.4,2.6s1.5,2.3,1.8,3.9c0.5,1.5,0.5,3.1,0.5,4.6 s-0.3,3.1-0.5,4.6c-0.3,1.3-1,2.8-1.8,3.9c-0.8,1-2.1,2.1-3.4,2.6c-1.5,0.5-3.1,1-4.6,1h-9.8V715.1L-90.2,715.1z M-86,735.8h4.1 c1.3,0,2.8-0.3,4.1-0.8c1-0.3,1.8-1,2.3-1.8c0.5-0.8,1-1.8,1.3-2.8c0.3-2.3,0.3-4.4,0-6.7c-0.3-1-0.5-2.1-1.3-2.8 c-0.5-0.8-1.3-1.5-2.3-1.8c-1.3-0.5-2.8-0.8-4.1-0.8H-86L-86,735.8L-86,735.8z"></path><path fill="#616365" d="M-66.2,715.1h3.9v3.6h-3.9V715.1z M-66.2,721.8h3.9v17.3h-3.9V721.8z"></path><path fill="#616365" d="M-42.2,738.1c0.3,2.3-0.8,4.4-2.3,5.9c-1.8,1.3-4.1,2.1-6.4,1.8c-0.8,0-1.8,0-2.6-0.3 c-0.8-0.3-1.5-0.5-2.3-1c-0.8-0.5-1.3-1-1.8-1.8c-0.5-0.8-0.8-1.5-0.8-2.6h3.9c0,0.5,0.3,1,0.5,1.3c0.3,0.3,0.5,0.5,1,0.8 c0.5,0.3,0.8,0.3,1.3,0.3h1.3c2.1,0.5,4.1-1,4.4-2.8c0-0.5,0-1,0-1.5v-2.6l0,0c-0.5,1-1.3,1.8-2.3,2.3c-1,0.5-2.1,0.8-3.1,0.8 c-1.3,0-2.6-0.3-3.6-0.8c-1-0.5-1.8-1-2.3-2.1c-0.5-0.8-1-1.8-1.3-2.8c-0.3-1.3-0.5-2.3-0.5-3.6c0-1,0.3-2.3,0.5-3.4 c0.3-1,0.8-2.1,1.5-2.8c0.8-0.8,1.5-1.5,2.6-1.8c1-0.5,2.3-0.8,3.4-0.8s2.1,0.3,3.1,0.8c0.8,0.5,1.5,1.3,2.1,2.1l0,0v-2.3h3.9 L-42.2,738.1L-42.2,738.1z M-50.7,736c0.8,0,1.5-0.3,2.1-0.5c0.5-0.3,1-0.8,1.5-1.3c0.3-0.8,0.5-1.3,0.8-2.1 c0.3-0.8,0.3-1.5,0.3-2.3c0-0.8,0-1.3-0.3-2.1c-0.3-0.5-0.5-1.3-0.8-1.8c-0.3-0.5-0.8-1-1.5-1.3c-1.3-0.8-2.8-0.8-4.1,0 c-0.5,0.3-1,0.8-1.3,1.3c-0.3,0.8-0.5,1.3-0.8,2.1c-0.3,1.3-0.3,2.8,0,4.1c0.3,0.5,0.5,1.3,0.8,1.8c0.3,0.5,0.8,1,1.3,1.3 C-52.2,735.8-51.5,736-50.7,736L-50.7,736z"></path><path fill="#616365" d="M-35.5,731.4c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.5,0.5,1,0.8,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-1.5,0.8-3.1,1.3-4.9,1.5 c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6s0.3-2.3,0.5-3.6 c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8s2.6,0.3,3.6,0.8c1,0.5,2.1,1.3,2.6,2.3 c0.8,1,1.3,2.1,1.5,3.4s0.5,2.6,0.3,3.9h-12.6V731.4L-35.5,731.4z M-26.5,728.8c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5 c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5c-0.3,0.5-0.3,1.3-0.5,1.8H-26.5z"></path><path fill="#616365" d="M-16.9,733.4c0,1,0.5,1.8,1.3,2.3c0.8,0.5,1.5,0.8,2.6,0.8h1.3c0.5,0,0.8-0.3,1.3-0.3 c0.5-0.3,0.8-0.5,1-0.8c0.3-0.5,0.3-0.8,0.3-1.3c0-0.5-0.3-1-0.5-1.3c-0.5-0.3-0.8-0.5-1.3-0.8c-0.5-0.3-1.3-0.3-1.8-0.5 c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.3-1-0.8-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3 c0-0.8,0.3-1.8,0.8-2.3c0.5-0.5,1-1,1.8-1.5c0.8-0.5,1.5-0.8,2.3-0.8c1.8-0.3,3.4-0.3,5.2,0c0.8,0.3,1.5,0.5,2.3,1 c1.5,0.8,2.3,2.6,2.3,4.1h-3.9c0-0.8-0.5-1.5-1.3-1.8c-0.8-0.3-1.5-0.5-2.3-0.5h-1c-0.3,0-0.8,0-1,0.3c-0.3,0.3-0.5,0.3-0.8,0.5 c-0.3,0.3-0.3,0.8-0.3,1c0,0.5,0.3,0.8,0.5,1c0.5,0.3,0.8,0.5,1.3,0.8c0.5,0.3,1.3,0.3,1.8,0.5c0.8,0.3,1.3,0.3,2.1,0.5 c0.8,0.3,1.3,0.3,2.1,0.5c0.8,0.3,1.3,0.5,1.8,1c0.5,0.3,1,0.8,1.3,1.5c0.3,0.5,0.5,1.3,0.5,2.1c0,1-0.3,1.8-0.8,2.6 c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.6,1c-1,0.3-1.8,0.3-2.8,0.3s-2.1,0-3.1-0.3c-0.8-0.3-1.5-0.5-2.3-1s-1.3-1-1.5-1.8 c-0.5-0.8-0.5-1.8-0.5-2.6h3.6L-16.9,733.4L-16.9,733.4z"></path><path fill="#616365" d="M-4,721.8h2.8v-5.2h3.9v5.2H6v2.8H2.7V735c0,0.3,0,0.5,0.3,0.8l0.5,0.5c0.3,0,0.8,0.3,1,0.3H6v2.8 c-0.5,0-0.8,0-1.3,0.3H3.5c-0.8,0-1.5,0-2.3-0.3l-1.5-0.8c-0.3-0.5-0.5-0.8-0.8-1.3c0-0.5-0.3-1.3-0.3-1.8v-10.3h-2.8v-3.4H-4 L-4,721.8z"></path><path fill="#616365" d="M8.9,715.1h3.9v3.6H8.9V715.1z M8.9,721.8h3.9v17.3H8.9V721.8z"></path><path fill="#616365" d="M15.1,721.8h4.1l4.4,13.4l0,0l4.1-13.4h3.9l-6.2,17.3H21L15.1,721.8z"></path><path fill="#616365" d="M37.3,731.4c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.5,0.5,1,0.8,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-1.5,0.8-3.1,1.3-4.9,1.5 c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6s0.3-2.3,0.5-3.6 c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8c1.3,0,2.6,0.3,3.6,0.8c1,0.5,2.1,1.3,2.6,2.3 c0.8,1,1.3,2.1,1.5,3.4c0.3,1.3,0.5,2.6,0.3,3.9H37.3V731.4L37.3,731.4z M46.3,728.8c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5 c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5c-0.3,0.5-0.3,1.3-0.5,1.8H46.3z"></path><path fill="#616365" d="M-290.8,775.5c0,0.3,0,0.8,0.3,1c0,0.3,0.3,0.3,0.8,0.3h1v2.6c-0.3,0-0.5,0-0.5,0.3c-0.3,0-0.5,0-0.8,0.3 h-1.3c-0.8,0-1.5-0.3-2.1-0.5c-0.5-0.3-1-1-1-1.5c-0.8,0.8-1.8,1.3-2.8,1.5s-2.1,0.5-3.1,0.5c-0.8,0-1.5,0-2.3-0.3s-1.3-0.5-1.8-1 s-1-1-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.5-2.6c0.3-0.5,1-1.3,1.5-1.5c0.5-0.5,1.3-0.8,2.1-0.8 c0.8-0.3,1.5-0.3,2.3-0.5c0.8-0.3,1.3-0.3,2.1-0.3c0.5,0,1,0,1.5-0.3c0.3,0,0.8-0.3,1-0.5c0.3-0.3,0.5-0.8,0.5-1.3 c0-0.5,0-0.8-0.3-1.3l-0.8-0.8c-0.3-0.3-0.8-0.3-1-0.3h-1.3c-1,0-1.8,0.3-2.6,0.8c-0.8,0.5-1.3,1.3-1.3,2.1h-3.9 c0-1,0.3-2.1,0.8-2.8c0.5-0.8,1-1.3,1.8-1.8c0.8-0.5,1.5-0.8,2.6-1c1-0.3,1.8-0.3,2.8-0.3c0.8,0,1.8,0,2.6,0.3l2.3,0.8 c0.5,0.3,1.3,1,1.5,1.5c0.5,0.8,0.8,1.5,0.5,2.3V775.5L-290.8,775.5L-290.8,775.5z M-294.7,770.6c-0.8,0.3-1.3,0.5-2.1,0.8 c-0.8,0-1.8,0.3-2.6,0.3s-0.8,0.3-1.3,0.3c-0.5,0-0.8,0.3-1,0.5l-0.8,0.8c-0.3,0.5-0.3,0.8-0.3,1.3c0,0.3,0,0.8,0.3,1l0.8,0.8 c0.3,0.3,0.8,0.3,1,0.3h1c0.5,0,0.8,0,1.3-0.3c0.5,0,1-0.3,1.3-0.5c0.5-0.3,0.8-0.5,1-1c0.3-0.5,0.5-1,0.5-1.5v-2.6L-294.7,770.6 L-294.7,770.6z"></path><path fill="#616365" d="M-286.7,762.1h3.6v2.6l0,0c0.5-1,1.3-1.8,2.3-2.3c1-0.5,2.1-0.8,3.1-0.8c2.8-0.3,5.7,1.8,5.9,4.9 c0,0.3,0,0.8,0,1v11.9h-3.9v-10.8c0-1-0.3-2.1-0.8-3.1c-0.5-0.8-1.5-1.3-2.6-1c-0.5,0-1.3,0-1.8,0.3s-1,0.5-1.3,1 c-0.3,0.5-0.5,1-0.8,1.5c-0.3,0.5-0.3,1.3-0.3,1.8v10.3h-3.9v-17.3L-286.7,762.1L-286.7,762.1z"></path><path fill="#616365" d="M-251.1,779.4h-3.6V777l0,0c-0.5,1-1.3,1.8-2.3,2.1c-1,0.5-2.1,0.8-3.1,0.8c-1.3,0-2.6-0.3-3.6-0.8 c-1-0.5-1.8-1.3-2.6-2.1c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6s0.3-2.8,0.5-4.1c0.5-1,1-2.1,1.8-2.8 c0.5-0.8,1.5-1.3,2.3-1.5c1-0.3,1.8-0.5,2.8-0.5c0.5,0,1,0,1.5,0.3c0.5,0,1,0.3,1.5,0.5l1.5,0.8c0.5,0.3,0.8,0.8,1,1.3l0,0v-8.8 h3.9v23.7H-251.1L-251.1,779.4z M-264.5,770.8c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1.3,0.8,1.8c0.5,0.5,1,1,1.5,1.3s1.3,0.5,2.1,0.5 s1.5-0.3,2.3-0.5c0.5-0.3,1-0.8,1.5-1.3c0.5-0.5,0.8-1.3,0.8-2.1c0-0.8,0.3-1.5,0.3-2.3c0-1.5-0.5-3.1-1.3-4.4 c-0.8-1-2.3-1.5-3.6-1.5c-0.8,0-1.5,0.3-2.3,0.5c-0.5,0.3-1.3,1-1.5,1.5c-0.5,0.5-0.8,1.3-0.8,2.1V770.8L-264.5,770.8z"></path><path fill="#616365" d="M-237.2,755.4h4.1v10.8l10.6-10.8h5.2l-9.5,9.5l10.3,14.4h-5.2l-7.7-11.3l-3.4,3.4v8h-4.1v-24 L-237.2,755.4L-237.2,755.4z"></path><path fill="#616365" d="M-214.2,755.4h3.9v3.6h-3.9V755.4z M-214.2,762.1h3.9v17.3h-3.9V762.1z"></path><path fill="#616365" d="M-190,779.4h-3.6V777l0,0c-0.5,1-1.3,1.8-2.3,2.1c-1,0.5-2.1,0.8-3.1,0.8c-1.3,0-2.6-0.3-3.6-0.8 c-1-0.5-1.8-1.3-2.6-2.1c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6s0.3-2.8,0.5-4.1c0.5-1,1-2.1,1.8-2.8 c0.5-0.8,1.5-1.3,2.3-1.5c1-0.3,1.8-0.5,2.8-0.5c0.5,0,1,0,1.5,0.3c0.5,0,1,0.3,1.5,0.5l1.5,0.8c0.5,0.3,0.8,0.8,1,1.3l0,0v-8.8 h3.9v23.7H-190L-190,779.4z M-203.4,770.8c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1.3,0.8,1.8c0.5,0.5,1,1,1.5,1.3 c0.5,0.3,1.3,0.5,2.1,0.5c0.8,0,1.5-0.3,2.3-0.5c0.5-0.3,1-0.8,1.5-1.3c0.5-0.5,0.8-1.3,0.8-2.1c0-0.8,0.3-1.5,0.3-2.3 c0-1.5-0.5-3.1-1.3-4.4c-0.8-1-2.3-1.5-3.6-1.5c-0.8,0-1.5,0.3-2.3,0.5c-0.5,0.3-1.3,1-1.5,1.5c-0.5,0.5-0.8,1.3-0.8,2.1V770.8z"></path><path fill="#616365" d="M-185.9,762.1h3.6v2.6l0,0c0.5-1,1.3-1.8,2.3-2.3c1-0.5,2.1-0.8,3.1-0.8c2.8-0.3,5.7,1.8,5.9,4.9 c0,0.3,0,0.8,0,1v11.9h-3.9v-10.8c0-1-0.3-2.1-0.8-3.1c-0.5-0.8-1.5-1.3-2.6-1c-0.5,0-1.3,0-1.8,0.3c-0.5,0.3-1,0.5-1.3,1 c-0.3,0.5-0.5,1-0.8,1.5c-0.3,0.5-0.3,1.3-0.3,1.8v10.3h-3.9v-17.3L-185.9,762.1L-185.9,762.1z"></path><path fill="#616365" d="M-163.7,771.6c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.3,0.5,1,1,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.3,1 c-0.8,0.3-1.8,0.3-2.6,0.3c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6 s0.3-2.3,0.5-3.6c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8c1.3,0,2.6,0.3,3.6,0.8 c1,0.5,2.1,1.3,2.6,2.3c0.8,1,1.3,2.1,1.5,3.4c0.3,1.3,0.5,2.6,0.3,3.9L-163.7,771.6L-163.7,771.6z M-154.7,769 c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5 c-0.3,0.5-0.3,1.3-0.3,1.8H-154.7z"></path><path fill="#616365" d="M-150,762.1h4.1l4.6,12.9l0,0l4.4-12.9h3.9l-6.7,18.3c-0.3,0.8-0.5,1.5-1,2.3c-0.3,0.5-0.5,1.3-1,1.8 c-0.5,0.5-1,1-1.5,1.3c-0.8,0.3-1.8,0.5-2.6,0.5c-0.8,0-1.8,0-2.6-0.3V783c0.3,0,0.8,0,1,0.3s0.8,0.3,1,0c0.3,0,0.8,0,1-0.3 c0.3,0,0.5-0.3,0.8-0.5c0.3-0.3,0.3-0.5,0.5-0.8s0.3-0.8,0.3-1l0.5-1.3L-150,762.1z"></path><path fill="#616365" d="M-120.6,755.4h9.8c1.5,0,3.4,0.3,4.6,1c1.3,0.5,2.3,1.5,3.4,2.6c1,1,1.5,2.3,1.8,3.9 c0.5,1.5,0.5,3.1,0.5,4.6s-0.3,3.1-0.5,4.6c-0.5,1.3-1,2.6-1.8,3.9c-0.8,1-2.1,2.1-3.4,2.6c-1.5,0.5-3.1,1-4.6,1h-9.8V755.4 L-120.6,755.4z M-116.5,776h4.1c1.3,0,2.8-0.3,4.1-0.8c1-0.3,1.8-1,2.3-1.8s1-1.8,1.3-2.8c0.3-2.3,0.3-4.4,0-6.7 c-0.3-1-0.5-2.1-1.3-2.8c-0.5-0.8-1.3-1.5-2.3-1.8c-1.3-0.5-2.8-0.8-4.1-0.8h-4.1V776L-116.5,776z"></path><path fill="#616365" d="M-96.9,755.4h3.9v3.6h-3.9V755.4z M-96.9,762.1h3.9v17.3h-3.9V762.1z"></path><path fill="#616365" d="M-86,773.7c0,1,0.5,1.8,1.3,2.3c0.8,0.5,1.5,0.8,2.6,0.8h1.3c0.5,0,0.8-0.3,1.3-0.3c0.5,0,0.8-0.3,1-0.8 c0.3-0.5,0.3-0.8,0.3-1.3c0-0.5-0.3-1-0.5-1.3c-0.5-0.3-0.8-0.5-1.3-0.8s-1.3-0.3-1.8-0.5c-0.8-0.3-1.3-0.3-2.1-0.5 c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.3-1-0.8-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.8-2.3 c0.5-0.5,1-1,1.8-1.5c0.8-0.5,1.5-0.8,2.3-0.8c1.8-0.3,3.4-0.3,5.2,0c0.8,0.3,1.5,0.5,2.3,1c0.5,0.3,1.3,1,1.5,1.5 c0.5,0.8,0.8,1.5,0.8,2.6h-3.9c0-0.8-0.5-1.5-1.3-1.8c-0.8-0.3-1.5-0.5-2.3-0.5h-1c-0.3,0-0.8,0-1,0.3c-0.3,0-0.5,0.3-0.8,0.5 c-0.3,0.3-0.3,0.8-0.3,1c0,0.5,0.3,0.8,0.5,1c0.5,0.3,0.8,0.5,1.3,0.8s1.3,0.3,1.8,0.5c0.8,0.3,1.3,0.3,2.1,0.5 c0.8,0.3,1.3,0.3,2.1,0.5c0.8,0.3,1.3,0.5,1.8,1c0.5,0.3,1,0.8,1.3,1.5c0.3,0.5,0.5,1.3,0.5,2.1c0,1-0.3,1.8-0.8,2.6 c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.6,1c-1,0.3-1.8,0.3-2.8,0.3c-1,0-2.1,0-3.1-0.3c-0.8-0.3-1.5-0.5-2.3-1 c-0.8-0.5-1.3-1-1.5-1.8c-0.5-0.8-0.5-1.8-0.5-2.6h3.6L-86,773.7L-86,773.7z"></path><path fill="#616365" d="M-68.2,771.6c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.3,0.5,1,1,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.3,1 c-0.8,0.3-1.8,0.3-2.6,0.3c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6 s0.3-2.3,0.5-3.6c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8s2.6,0.3,3.6,0.8c1,0.5,2.1,1.3,2.6,2.3 c0.8,1,1.3,2.1,1.5,3.4c0.3,1.3,0.5,2.6,0.3,3.9L-68.2,771.6L-68.2,771.6z M-59.5,769c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5 c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5c-0.3,0.5-0.3,1.3-0.5,1.8H-59.5z"></path><path fill="#616365" d="M-38.1,775.5c0,0.3,0,0.8,0.3,1c0.3,0.3,0.5,0.3,0.8,0.3h1v2.6c-0.3,0-0.5,0-0.5,0.3c-0.3,0-0.5,0-0.8,0.3 c-0.3,0-0.5,0-0.8,0h-0.5c-0.8,0-1.5-0.3-2.1-0.5c-0.5-0.3-1-1-1-1.5c-0.8,0.8-1.8,1.3-2.8,1.5s-2.1,0.5-3.1,0.5 c-0.8,0-1.5,0-2.3-0.3c-0.8-0.3-1.3-0.5-1.8-1s-1-1-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.5-2.6 c0.3-0.5,1-1.3,1.5-1.5c0.5-0.5,1.3-0.8,2.1-0.8c0.8-0.3,1.5-0.3,2.3-0.5c0.8-0.3,1.3-0.3,2.1-0.3c0.5,0,1.3-0.3,1.5-0.3 c0.3,0,0.8-0.3,1-0.5c0.3-0.3,0.5-0.8,0.5-1.3c0-0.5,0-0.8-0.3-1.3l-0.8-0.8c-0.3-0.3-0.8-0.3-1-0.3h-1.3c-1,0-1.8,0.3-2.6,0.8 c-0.8,0.5-1.3,1.3-1.3,2.1H-53c0-1,0.3-2.1,0.8-2.8c0.5-0.8,1-1.3,1.8-1.8c0.8-0.5,1.5-0.8,2.6-1c1-0.3,1.8-0.3,2.8-0.3 c0.8,0,1.8,0,2.6,0.3l2.3,0.8c0.5,0.3,1.3,1,1.5,1.5c0.5,0.8,0.8,1.5,0.5,2.3V775.5L-38.1,775.5z M-41.9,770.6 c-0.8,0.3-1.3,0.5-2.1,0.8c-0.8,0-1.8,0.3-2.6,0.3c-0.8,0-0.8,0.3-1.3,0.3s-0.8,0.3-1,0.5l-0.8,0.8c-0.3,0.5-0.3,0.8-0.3,1.3 c0,0.3,0,0.8,0.3,1l0.8,0.8c0.3,0.3,0.8,0.3,1,0.3h1c0.5,0,0.8,0,1.3-0.3c0.5,0,1-0.3,1.3-0.5c0.5-0.3,0.8-0.5,1-1 c0.3-0.5,0.5-1,0.5-1.5v-2.6L-41.9,770.6L-41.9,770.6z"></path><path fill="#616365" d="M-31.1,773.7c0,1,0.5,1.8,1.3,2.3c0.8,0.5,1.5,0.8,2.6,0.8h1.3c0.5,0,0.8-0.3,1.3-0.3s0.8-0.3,1-0.8 c0.3-0.5,0.3-0.8,0.3-1.3c0-0.5-0.3-1-0.5-1.3c-0.5-0.3-0.8-0.5-1.3-0.8s-1.3-0.3-1.8-0.5c-0.8-0.3-1.3-0.3-2.1-0.5 c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.3-1-0.8-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.8-2.3 c0.5-0.5,1-1,1.8-1.5c0.8-0.5,1.5-0.8,2.3-0.8c1.8-0.3,3.4-0.3,5.2,0c0.8,0.3,1.5,0.5,2.3,1c0.5,0.3,1.3,1,1.5,1.5 c0.5,0.8,0.8,1.5,0.8,2.6h-3.9c0-0.8-0.5-1.5-1.3-1.8c-0.8-0.3-1.5-0.5-2.3-0.5h-1c-0.3,0-0.8,0-1,0.3c-0.3,0-0.5,0.3-0.8,0.5 c-0.3,0.3-0.3,0.8-0.3,1c0,0.5,0.3,0.8,0.5,1c0.5,0.3,0.8,0.5,1.3,0.8c0.5,0.3,1.3,0.3,1.8,0.5c0.8,0.3,1.3,0.3,2.1,0.5 c0.8,0.3,1.3,0.3,2.1,0.5c0.8,0.3,1.3,0.5,1.8,1c0.5,0.3,1,0.8,1.3,1.5c0.3,0.5,0.5,1.3,0.5,2.1c0,1-0.3,1.8-0.8,2.6 c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.6,1c-1,0.3-1.8,0.3-2.8,0.3s-2.1,0-3.1-0.3c-0.8-0.3-1.5-0.5-2.3-1 c-0.8-0.5-1.3-1-1.5-1.8c-0.5-0.8-0.5-1.8-0.5-2.6h3.6L-31.1,773.7L-31.1,773.7z"></path><path fill="#616365" d="M-13.6,771.6c0,0.8,0,1.3,0.3,2.1c0.3,0.5,0.5,1,0.8,1.5c0.3,0.5,1,1,1.5,1c0.5,0.3,1.3,0.5,2.1,0.5 c1,0,1.8-0.3,2.6-0.8c0.8-0.5,1.3-1.3,1.5-2.1h3.6c-0.3,1-0.5,1.8-1,2.6c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.3,1 c-0.8,0.3-1.8,0.3-2.6,0.3c-1.3,0-2.6-0.3-3.6-0.8c-1-0.3-1.8-1-2.6-1.8c-0.8-0.8-1.3-1.8-1.5-2.8c-0.3-1.3-0.5-2.3-0.5-3.6 s0.3-2.3,0.5-3.6c0.5-1,1-1.8,1.5-2.8c0.8-0.8,1.5-1.5,2.6-2.1c1-0.5,2.3-0.8,3.6-0.8s2.6,0.3,3.6,0.8c1,0.5,2.1,1.3,2.6,2.3 c0.8,1,1.3,2.1,1.5,3.4c0.3,1.3,0.5,2.6,0.3,3.9L-13.6,771.6L-13.6,771.6z M-4.8,769c0-0.5-0.3-1.3-0.3-1.8l-0.8-1.5 c-0.3-0.5-0.8-0.8-1.3-1c-1.3-0.3-2.3-0.3-3.6,0c-0.5,0.3-1,0.5-1.3,1c-0.5,0.5-0.8,1-1,1.5c-0.3,0.5-0.3,1.3-0.5,1.8H-4.8z"></path><path fill="#616365" d="M5,773.7c0,1,0.5,1.8,1.3,2.3c0.8,0.5,1.5,0.8,2.6,0.8h1.3c0.5,0,0.8-0.3,1.3-0.3c0.5,0,0.8-0.3,1-0.8 c0.3-0.5,0.3-0.8,0.3-1.3c0-0.5-0.3-1-0.5-1.3c-0.5-0.3-0.8-0.5-1.3-0.8s-1.3-0.3-1.8-0.5c-0.8-0.3-1.3-0.3-2.1-0.5 c-0.8-0.3-1.3-0.3-2.1-0.5c-0.8-0.3-1.3-0.5-1.8-1c-0.5-0.3-1-0.8-1.3-1.5c-0.3-0.8-0.5-1.5-0.5-2.3c0-0.8,0.3-1.8,0.8-2.3 c0.5-0.5,1-1,1.8-1.5c0.8-0.5,1.5-0.8,2.3-0.8c1.8-0.3,3.4-0.3,5.2,0c0.8,0.3,1.5,0.5,2.3,1c0.5,0.3,1.3,1,1.5,1.5 c0.5,0.8,0.8,1.5,0.8,2.6h-3.9c0-0.8-0.5-1.5-1.3-1.8c-0.8-0.3-1.5-0.5-2.3-0.5h-1c-0.3,0-0.8,0-1,0.3c-0.3,0-0.5,0.3-0.8,0.5 c-0.3,0.3-0.3,0.8-0.3,1c0,0.5,0.3,0.8,0.5,1c0.5,0.3,0.8,0.5,1.3,0.8s1.3,0.3,1.8,0.5c0.8,0.3,1.3,0.3,2.1,0.5 c0.8,0.3,1.3,0.3,2.1,0.5c0.8,0.3,1.3,0.5,1.8,1c0.5,0.3,1,0.8,1.3,1.5c0.3,0.5,0.5,1.3,0.5,2.1c0,1-0.3,1.8-0.8,2.6 c-0.5,0.8-1,1.3-1.8,1.8c-0.8,0.5-1.5,0.8-2.6,1c-1,0.3-1.8,0.3-2.8,0.3s-2.1,0-3.1-0.3c-0.8-0.3-1.5-0.5-2.3-1 c-0.8-0.5-1.3-1-1.5-1.8c-0.5-0.8-0.5-1.8-0.5-2.6H5L5,773.7L5,773.7z"></path></g></g></svg></div></a></div><div class="PageHeader_searchContent__5k0zQ col"><input name="query" type="text" placeholder="Search the Website..." value=""/><button aria-label="" class="Button_button__OFOdO Button_auto__peQWd Button_primary__WTwSy a a-primary"><svg xmlns="http://www.w3.org/2000/svg" width="23" height="23" fill="currentColor" class="bi bi-search" viewBox="0 0 16 16"><path d="M11.742 10.344a6.5 6.5 0 1 0-1.397 1.398h-.001c.03.04.062.078.098.115l3.85 3.85a1 1 0 0 0 1.415-1.414l-3.85-3.85a1.007 1.007 0 0 0-.115-.1zM12 6.5a5.5 5.5 0 1 1-11 0 5.5 5.5 0 0 1 11 0z"></path></svg></button></div></div><div class="NavBar_stickyContainer___XV6p"><div class="NavBar_headerContainer__KSr1m row"><div class="NavBar_content__GxtKX col"><a href="/home">NIDDK Central Repository</a></div><div class="NavBar_content__GxtKX col"><a href="/user/login"><button aria-label="Sign In / Register" class="Button_button__OFOdO Button_auto__peQWd Button_login__gkznn a a-primary">Sign In / Register</button></a></div></div><nav class="NavBar_NavigationBar__3wGqF navbar navbar-expand navbar-light"><button aria-controls="navbar-collapse" type="button" aria-label="Toggle navigation" class="NavBar_toggle__rY7gT navbar-toggler collapsed"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="30" height="30" fill="white" class="bi bi-list"><path fill-rule="evenodd" d="M2.5 12a.5.5 0 0 1 .5-.5h10a.5.5 0 0 1 0 1H3a.5.5 0 0 1-.5-.5m0-4a.5.5 0 0 1 .5-.5h10a.5.5 0 0 1 0 1H3a.5.5 0 0 1-.5-.5m0-4a.5.5 0 0 1 .5-.5h10a.5.5 0 0 1 0 1H3a.5.5 0 0 1-.5-.5"></path></svg></button><div class="NavBar_collapse__Ki_F1 navbar-collapse collapse" id="navbar-collapse"><div class="NavBar_navItem__ePCO5 dropdown nav-item"><a id="react-aria-:R9ssm:" aria-expanded="false" role="button" class="NavBar_dropdownToggle__8BR17 dropdown-toggle nav-link" tabindex="0" href="#"><div>Repository Resources<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="1em" height="1em" fill="currentColor" class="bi bi-caret-down-fill"><path d="M7.247 11.14 2.451 5.658C1.885 5.013 2.345 4 3.204 4h9.592a1 1 0 0 1 .753 1.659l-4.796 5.48a1 1 0 0 1-1.506 0z"></path></svg></div></a></div><div class="NavBar_navItem__ePCO5 dropdown nav-item"><a id="react-aria-:Rassm:" aria-expanded="false" role="button" class="NavBar_dropdownToggle__8BR17 dropdown-toggle nav-link" tabindex="0" href="#"><div>Helpful Information<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="1em" height="1em" fill="currentColor" class="bi bi-caret-down-fill"><path d="M7.247 11.14 2.451 5.658C1.885 5.013 2.345 4 3.204 4h9.592a1 1 0 0 1 .753 1.659l-4.796 5.48a1 1 0 0 1-1.506 0z"></path></svg></div></a></div><div class="NavBar_navItem__ePCO5 dropdown nav-item"><a id="react-aria-:Rbssm:" aria-expanded="false" role="button" class="NavBar_dropdownToggle__8BR17 dropdown-toggle nav-link" tabindex="0" href="#"><div>Requests<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="1em" height="1em" fill="currentColor" class="bi bi-caret-down-fill"><path d="M7.247 11.14 2.451 5.658C1.885 5.013 2.345 4 3.204 4h9.592a1 1 0 0 1 .753 1.659l-4.796 5.48a1 1 0 0 1-1.506 0z"></path></svg></div></a></div><div class="NavBar_navItem__ePCO5 dropdown nav-item"><a id="react-aria-:Rcssm:" aria-expanded="false" role="button" class="NavBar_dropdownToggle__8BR17 dropdown-toggle nav-link" tabindex="0" href="#"><div>About NIDDK-CR<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="1em" height="1em" fill="currentColor" class="bi bi-caret-down-fill"><path d="M7.247 11.14 2.451 5.658C1.885 5.013 2.345 4 3.204 4h9.592a1 1 0 0 1 .753 1.659l-4.796 5.48a1 1 0 0 1-1.506 0z"></path></svg></div></a></div></div></nav></div><div style="position:relative;overflow:hidden;width:100%" class="Banner_parallax__Gp6_i"></div><div class="PublicationOverview_Container__b6CEI container-fluid"><div class="PublicationOverview_alignBetween__YwqeY"><h4 class="PublicationOverview_bold__wVi7r">Publication Information</h4><div class="pullRight PublicationOverview_mobile__vM_qo"><button aria-label="Login to Start a Request" class="Button_button__OFOdO Button_auto__peQWd Button_primary__WTwSy a a-primary">Login to Start a Request</button></div></div><div class="PublicationOverview_Row__VtCdx PublicationOverview_topRow__Eiai4 PublicationOverview_graybox__OAwLA row"><div class="col-lg-6"><div class="PublicationOverview_representativeItem__ioGsR"><div><div class="PublicationOverview_bold__wVi7r">DOI</div><div><a href="https://doi.org/10.1016/j.juro.2017.11.080">10.1016/j.juro.2017.11.080</a></div></div></div><div class="PublicationOverview_representativeItem__ioGsR"><div><div class="PublicationOverview_bold__wVi7r">PubMed ID</div><div><a href="https://www.pubmed.ncbi.nlm.nih.gov/29198997">29198997</a></div></div></div><div class="PublicationOverview_representativeItem__ioGsR"><div><div class="PublicationOverview_bold__wVi7r">Public Release Type</div><div>Journal</div></div></div><div class="PublicationOverview_representativeItem__ioGsR"><div><div class="PublicationOverview_bold__wVi7r">Publication Year</div><div>2018</div></div></div></div><div class="col-lg-6"><div class="PublicationOverview_representativeItem__ioGsR"><div><div class="PublicationOverview_bold__wVi7r">Affiliation</div><div>University of California, Irvine, Irvine, California; Children&#x27;s Hospital of Orange County, Orange, California. Electronic address: aekhoury@uci.edu.</div></div></div><div class="PublicationOverview_representativeItem__ioGsR"><div><div class="PublicationOverview_bold__wVi7r">Authors</div><div>Alam Y, Khoury A, Wang ZT, Wehbi E</div></div></div><div class="PublicationOverview_representativeItem__ioGsR"><div><div class="PublicationOverview_bold__wVi7r">Studies</div><div><a href="/study/51">RIVUR</a></div></div></div></div></div><div class="PublicationOverview_Row__VtCdx row"><h6><strong>Citation</strong></h6><span><span>Wang ZT, Wehbi E, Alam Y, Khoury A. A Reanalysis of the RIVUR Trial Using a Risk Classification System. <i>J Urol</i> 2018 Jun;199(6):1608-1614. Epub 2017 Dec 2.</span></span></div><div class="PublicationOverview_Row__VtCdx row"><h4><strong>Abstract</strong></h4><div>The RIVUR (Randomized Intervention for Children with Vesicoureteral Reflux) trial showed a 50% decrease in the risk of urinary tract infection recurrence in children with reflux receiving continuous antibiotic prophylaxis. We reanalyzed the RIVUR data with the purpose of using a risk classification system to identify children who are more likely to benefit from continuous antibiotic prophylaxis.</div></div></div><footer class="Footer_footer__ylvxI"><div class="Footer_footerBackground__oz0ra Footer_colorful__6nhIt "></div><div class="Footer_content__kdMvs"><div class="container"><div class="Footer_footerHeader__BQGGW row">NIH... Turning Discovery into Health 庐</div><div class="mb-2 row"><div class="Footer_column__P3enx undefined col-sm-3"><p class="Footer_columnTitle__wFePf Footer_gray__JEbav"><a href="/pages/repository">Repository Resources</a></p><a href="/search/study">Studies</a><a href="/search/counts">Material Counts</a><a href="/requests/approved/data">List of Approved Requestors</a><a href="/publications">Publications</a></div><div class="Footer_column__P3enx col-sm-3"><p class="Footer_columnTitle__wFePf Footer_teal__of3yb"><a href="/pages/helpful_information">Helpful Information</a></p><a href="/pages/general_information">General Information</a><a href="/pages/for_requestors">For Requestors</a><a href="/pages/for_submitters">For Submitters</a><a href="/pages/instructional_materials">Educational/Instructional Information</a><a href="/pages/data_challenges">Data Challenges</a><a href="/pages/externa_links">External Links</a></div><div class="Footer_column__P3enx col-sm-3"><p class="Footer_columnTitle__wFePf Footer_blue__h5Qmd"><a href="/pages/requests">Requests</a></p><a href="/requests/reuse/data-request">Data Request</a><a href="/requests/biospecimen_types">Specimen Request</a></div><div class="Footer_column__P3enx col-sm-3"><p class="Footer_columnTitle__wFePf Footer_blue__h5Qmd"><a href="/pages/about_niddk_cr">About NIDDK-CR</a></p><a href="/pages/about">About NIDDK-CR</a><a href="/news">R4R News</a><a href="/faq">Frequently Asked Questions</a><a href="/pages/site_map">Site Navigation Map</a><a href="/pages/definitions">Definitions</a><a href="/contact">Contact the NIDDK-CR</a></div></div></div></div><div class="Footer_blackFooter__dTd_Q"><div class="Footer_blackFooterContainer__eegTA container"><div class="Footer_footerLinks__5nXNj row"><ul><li>v. 02.0.1</li><li><a href="/pages/privacy/">Privacy Policy</a></li><li><a href="https://www.niddk.nih.gov/freedom-information-act">Freedom of Information Act</a></li><li><a href="/pages/accessibility/">Accessibility</a></li><li><a href="https://www.niddk.nih.gov/disclaimers">Disclaimers</a></li><li><a href="https://www.niddk.nih.gov/copyright">Copyright</a></li><li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html">Vulnerability Disclosure Policy</a></li><li><a href="/pages/site_map/">Site Map</a></li></ul><ul><li><a href="https://www.hhs.gov/"><span>U.S. Department of Health and Human Services</span></a></li><li itemProp="memberOf" itemType="http://schema.org/GovernmentOrganization"><a href="https://www.nih.gov/" itemProp="url"><span itemProp="name">National Institutes of Health</span></a></li><li><a href="https://www.niddk.nih.gov/">NIDDK Home</a></li></ul></div><div class="Footer_ctsContainer__dnT05 row"><a href="https://doi.org/10.34894/NOYYSF" target="_blank" rel="noopener noreferrer"><img src="/images/CoreTrustSeal-logo-transparent.png" class="Footer_ctsLogo__nRZwO" alt="Core Trust Seal Logo"/></a><div><a href="https://amt.coretrustseal.org/certificates">Core Trustworthy Data Repository</a></div></div></div></div></footer></div></div></div><script id="__NEXT_DATA__" type="application/json">{"props":{"pageProps":{"publicationId":"1068","publicationData":{"Title":[{"propertyValue":["A Reanalysis of the RIVUR Trial Using a Risk Classification System."],"label":"Title"}],"Representative":[{"propertyValue":["29198997"],"label":"PMID"},{"propertyValue":["Journal"],"label":"Public Release Type"},{"propertyValue":["2018"],"label":"Publication Year"},{"propertyValue":["10.1016/j.juro.2017.11.080"],"label":"DOI"},{"propertyValue":["Secondary Research"],"label":"Public Release Origin"}],"Detail":[{"propertyValue":["The RIVUR (Randomized Intervention for Children with Vesicoureteral Reflux) trial showed a 50% decrease in the risk of urinary tract infection recurrence in children with reflux receiving continuous antibiotic prophylaxis. We reanalyzed the RIVUR data with the purpose of using a risk classification system to identify children who are more likely to benefit from continuous antibiotic prophylaxis."],"label":"Abstract"},{"propertyValue":["\u003cspan\u003eWang ZT, Wehbi E, Alam Y, Khoury A. A Reanalysis of the RIVUR Trial Using a Risk Classification System. \u003ci\u003eJ Urol\u003c/i\u003e 2018 Jun;199(6):1608-1614. Epub 2017 Dec 2.\u003c/span\u003e"],"label":"Citation"},{"propertyValue":["University of California, Irvine, Irvine, California; Children's Hospital of Orange County, Orange, California. Electronic address: aekhoury@uci.edu."],"label":"Affiliation"},{"propertyValue":["Alam Y","Khoury A","Wang ZT","Wehbi E"],"label":"Author"}]},"publicationStudies":[{"studyId":51,"studyName":"Randomized Intervention for Children with Vesico Ureteral Reflux","studyAcronym":"RIVUR"}],"baseUrl":"https://repository.niddk.nih.gov","siteUrl":"https://repository.niddk.nih.gov"},"__N_SSP":true},"page":"/publications/[publicationId]","query":{"publicationId":"1068"},"buildId":"4IwPCL7p9Vb_-_lB6rNWm","isFallback":false,"isExperimentalCompile":false,"gssp":true,"scriptLoader":[]}</script></body></html>

Pages： 1 2 3 4 5 6 7 8 9 10