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class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">29797</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (3495)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (19710)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">Nanoparticles/chemistry</label> </div> <div 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Magnetic mesoporous silica nanoparticles loaded with peptides for the targeted repair of cavernous nerve injury underlying erectile dysfunction. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122811. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39265373' target='_blank'>39265373</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122811' target='_blank'>10.1016/j.biomaterials.2024.122811</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122811','39265373', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122811' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/14/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.biomaterials.2024.122811" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Erectile dysfunction (ED) is a common male sexual disorder characterized by repeated or persistent difficulty in achieving or maintaining an erection. It can arise from various factors, with cavernous nerve injury (CNI) from radical prostatectomy being a predominant cause of iatrogenic ED, posing significant clinical concerns. The complexity of cavernous tissue damage in CNI-induced ED (CNIED) often results in poor efficacy and resistance to conventional vascular ED treatments. To address CNI-induced ED, this study developed a system of magnetic mesoporous silica nanoparticles (MSNs) loaded with peptides for targeted treatment. Core-shell Fe3O4-coated MSNs were used as drug carriers and loaded with RADA16-I/RAD-RGI peptides (PD) to create a neurotrophic microenvironment to treat peripheral nerve defects. Furthermore, the neuro-targeting peptide HLNILSTLWKYR (PT) was grafted onto MSNs. The in vivo therapeutic effect was evaluated using a rat bilateral cavernous nerve injury (BCNI) model. The results showed that the neuro-targeted Fe3O4@SiO2-PT-PD nanoparticles significantly promoted regeneration of the cavernous nerve and restored erectile function. This promising strategy offers significant clinical potential for treating CNI-induced ED. Nanomedicine technology has the potential to not only improve treatment outcomes but also reduce side effects in healthy cells, paving the way for more accurate targeted repair of cavernous nerve damage. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cavernous+nerve+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cavernous nerve injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Erectile+dysfunction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Erectile dysfunction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetic+mesoporous+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetic mesoporous nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve regeneration</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Erectile+Dysfunction%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Erectile Dysfunction/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Erectile+Dysfunction%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Erectile Dysfunction/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Silicon+Dioxide%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Silicon Dioxide/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%2c+Sprague-Dawley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats, Sprague-Dawley</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Penis%2finnervation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Penis/innervation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Porosity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Porosity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnetite+Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnetite Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peripheral+Nerve+Injuries%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peripheral Nerve Injuries/therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Wang K</b>, Sun Y, Zhu K, Liu Y, Zheng X, Yang Z, Man F, Huang L, Zhu Z, Huang Q, Li Y, Dong H, Zhao J, Li Y. Anti-pyroptosis biomimetic nanoplatform loading puerarin for myocardial infarction repair: From drug discovery to drug delivery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122890. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39427429' target='_blank'>39427429</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122890' target='_blank'>10.1016/j.biomaterials.2024.122890</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122890','39427429', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122890' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.biomaterials.2024.122890" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis is a critical pathological mechanism implicated in myocardial damage following myocardial infarction (MI), and the crosstalk between macrophages and pyroptotic cardiomyocytes presents a formidable challenge for anti-pyroptosis therapies of MI. However, as single-target pyroptosis inhibitors frequently fail to address this crosstalk, the efficacy of anti-pyroptosis treatment post-MI remains inadequate. Therefore, the exploration of more potent anti-pyroptosis approaches is imperative for improving outcomes in MI treatment, particularly in addressing the crosstalk between macrophages and pyroptotic cardiomyocytes. Here, in response to this crosstalk, we engineered an anti-pyroptosis biomimetic nanoplatform (NM@PDA@PU), employing polydopamine (PDA) nanoparticles enveloped with neutrophil membrane (NM) for targeted delivery of puerarin (PU). Notably, network pharmacology is deployed to discern the most efficacious anti-pyroptosis drug (puerarin) among the 7 primary active monomers of TCM formulations widely applied in clinical practice and reveal the effect of puerarin on the crosstalk. Additionally, targeted delivery of puerarin could disrupt the malignant crosstalk between macrophages and pyroptotic cardiomyocytes, and enhance the effect of anti-pyroptosis by not only directly inhibiting cardiomyocytes pyroptosis through NLRP3-CASP1-IL-1β/IL-18 signal pathway, but reshaping the inflammatory microenvironment by reprogramming macrophages to anti-inflammatory M2 subtype. Overall, NM@PDA@PU could enhance anti-pyroptosis effect by disrupting the crosstalk between M1 macrophages and pyroptotic cardiomyocytes to protect cardiomyocytes, ameliorate cardiac function and improve ventricular remodeling, which providing new insights for the efficient treatment of MI. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crosstalk%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crosstalk</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardial+infarction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardial infarction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Puerarin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Puerarin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardial+Infarction%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardial Infarction/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Cardiac%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Cardiac/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Indoles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Indoles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Nie S</b>, Yang B, Ma R, Zha L, Qin Y, Ou L, Chen X, Li L. Synthetic nanomaterials for spleen-specific mRNA delivery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122859. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39362024' target='_blank'>39362024</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122859' target='_blank'>10.1016/j.biomaterials.2024.122859</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122859','39362024', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122859' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.biomaterials.2024.122859" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In recent years, mRNA vaccine has achieved increasing interest owing to its high potency, safety, ease of production, and low-cost manufacturing. Currently approved mRNA vaccines are administered intramuscularly to transfect local antigen-presenting cells (APCs) to initiate low to moderate immune responses. Spleen, the largest secondary lymphoid organ in the body which contains a large number of APCs close to B and T lymphocytes, could be the ideal site for effective initiation of an enhanced immune response. Here, we provide an overview of the recent advances in the development of synthetic materials for spleen-specific mRNA delivery, and lipid nanoparticle-based approaches will be highlighted. We further discuss the main challenges for spleen-specific mRNA delivery to provide a reference for the development of next-generation synthetic nanomaterials with optimal properties. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LNPs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LNPs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipoplexes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipoplexes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polyplexes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polyplexes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spleen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spleen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA delivery</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spleen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spleen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanostructures%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanostructures/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Bhansali D</b>, Tu NH, Inoue K, Teng S, Li T, Tran HD, Kim DH, Dong J, Peach CJ, Sokrat B, Jensen DD, Dolan JC, Yamano S, Robinson VM, Bunnett NW, Albertson DG, Leong KW, Schmidt BL. PAR<sub>2</sub> on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122874. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39418848' target='_blank'>39418848</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122874' target='_blank'>10.1016/j.biomaterials.2024.122874</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122874','39418848', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(4);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122874' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.biomaterials.2024.122874" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR2, encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral cancer pain. PAR2 is a G protein-coupled receptor (GPCR) expressed on neurons and cells in the cancer microenvironment. Sustained signaling of PAR2 from endosomes of neurons mediates sensitization and nociception. We focused on the differential contribution of PAR2 on oral cancer cells and neurons to oral cancer pain and whether encapsulation of a PAR2 inhibitor, AZ3451 in nanoparticles (NP) more effectively reverses PAR2 activation. We report that F2RL1 was overexpressed in human oral cancers and cancer cell lines. Deletion of F2RL1 on cancer cells reduced cancer-associated mechanical allodynia. A third-generation polyamidoamine dendrimer, functionalized with cholesterol was self-assembled into NPs encapsulating AZ3451. NP encapsulated AZ3451 (PAMAM-Chol-AZ NPs) more effectively reversed activation of PAR2 at the plasma membrane and early endosomes than free drug. The PAMAM-Chol-AZ NPs showed greater efficacy in reversing nociception than free drug, with respect to both level and duration, in three preclinical mouse models of oral cancer pain. The antinociceptive efficacy was confirmed with an operant orofacial assay. Genetic deletion of F2RL1 on cancer cells or F2rl1 on neurons each partially reversed mechanical cancer allodynia. The remaining nociception could be effectively reversed by PAMAM-Chol-AZ NPs. These findings suggest that PAR2 on oral cancer cells and neurons contribute to oral cancer nociception and NPs loaded with a PAR2 antagonist provide increased antinociception and improved oral function compared to free drug. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+cancer+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral cancer pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PAR(2)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PAR(2)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protease-activated+receptor+2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protease-activated receptor 2</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+PAR-2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, PAR-2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+Pain%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer Pain/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nociceptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nociceptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nociceptors%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nociceptors/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDCR+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DE029694 NIDCR NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Kim HL</b>, Saravanakumar G, Lee S, Jang S, Kang S, Park M, Sobha S, Park SH, Kim SM, Lee JA, Shin E, Kim YJ, Jeong HS, Kim D, Kim WJ. Poly(β-amino ester) polymer library with monomer variation for mRNA delivery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122896. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39426123' target='_blank'>39426123</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122896' target='_blank'>10.1016/j.biomaterials.2024.122896</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122896','39426123', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122896' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.biomaterials.2024.122896" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Non-viral vectors for mRNA delivery primarily include lipid nanoparticles (LNPs) and polymers. While LNPs are known for their high mRNA delivery efficiency, they can induce excessive immune responses and cause off-target effects, potentially leading to side effects. In this study, we aimed to explore polymer-based mRNA delivery systems as a viable alternative to LNPs, focusing on their mRNA delivery efficiency and potential application in mRNA vaccines. We created a library of poly(β-amino ester) (PBAE) polymers by combining various amine monomers and acrylate monomers. Through screening this polymer library, we identified specific polymer nanoparticles (PNPs) that demonstrated high mRNA expression efficiency, with sustained mRNA expression for up to two weeks. Furthermore, the PNPs showed mRNA expression only at the injection site and did not exhibit liver toxicity. Additionally, when assessing immune activation, the PNPs significantly induced T-cell immune activation and were effective in the plaque reduction neutralization test. These results suggest that polymer-based mRNA delivery systems not only hold potential for use in mRNA vaccines but also show promise for therapeutic applications. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Poly(%ce%b2-amino+ester)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Poly(β-amino ester)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymer+library%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymer library</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymer+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymer nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+vaccine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA vaccine</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Transfer+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Transfer Techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Huang Y</b>, Xu J, Sun G, Cheng X, An Y, Yao X, Nie G, Zhang Y. Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122822. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39270625' target='_blank'>39270625</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122822' target='_blank'>10.1016/j.biomaterials.2024.122822</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122822','39270625', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122822' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.biomaterials.2024.122822" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Reactive oxygen species (ROS) play crucial roles in the pathogenesis of inflammatory bowel disease (IBD) by disrupting the mucosal barrier and subsequently leading to the dysregulation of the gut microbiome. Therefore, ROS scavengers present a promising and comprehensive strategy for the effective IBD treatment. In the current work, we explored the therapeutic potential of cerium dioxide (CeO2) nano-enzyme, which is well-known for their potent antioxidant properties and capability to mimic natural antioxidant enzymes in the regulation of oxidative stress. We developed a novel enteric-coated nanomedicine (CeO2@S100) aiming at improving the oral delivery efficacy of CeO2 in the complex gastrointestinal environment. CeO2@S100 is composed of a CeO2 nanoparticle core and a protective polyacrylic acid resin shell (Eudragit S100), ensuring targeted delivery of the core specifically at inflamed intestinal sites due to the negative surface charge. In vivo experiments revealed CeO2@S100 significantly alleviates the IBD by balancing oxidative stress and regulating gut microbiota in a dextran sulfate sodium-induced mouse colitis model. The uncomplicated synthesis of CeO2@S100 highlights its promise for clinical use, presenting an effective and safe approach to managing IBD. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CeO(2)+nano-enzyme%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CeO(2) nano-enzyme</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eudragit+S100%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eudragit S100</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+microbiota+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal microbiota regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+scavenger%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS scavenger</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerium%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerium/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerium%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerium/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dextran+Sulfate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dextran Sulfate</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Wang X</b>, Xue Y, Hao K, Peng B, Chen H, Liu H, Wang J, Cao J, Dong W, Zhang S, Yang Q, Li J, Lei W, Feng Y. Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122845. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39326362' target='_blank'>39326362</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122845' target='_blank'>10.1016/j.biomaterials.2024.122845</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122845','39326362', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122845' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.biomaterials.2024.122845" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoarthritis (OA) is a prevalent degenerative disease characterized by irreversible destruction of articular cartilage, for which no current drugs are known to modify its progression. While intra-articular (IA) injections of hyaluronic acid (HA) offer temporary relief, their effectiveness and long-term benefits are debated. Alpha-ketoglutarate (αKG) has potential chondroprotective properties, but its use is limited by a short half-life and poor cartilage-targeting efficiency. Here, we developed self-assembled HA-αKG nanoparticles (NPs) to combine the benefits of both HA and αKG, showing stability, bioavailability, and sustained pH-responsive release in the knee joint. In both early and advanced OA stages in mice, HA, αKG, and HA-αKG NPs could relieve pain, enhance mobility, and reduce cartilage damage, with HA-αKG NPs demonstrating the best efficacy. Mechanistically, αKG not only promotes cartilage matrix synthesis but also inhibits degradation by activating the PERK-ATF4 signaling pathway to reduce endoplasmic reticulum stress (ERS) in chondrocytes. This study highlights the therapeutic potential of HA-αKG NPs for treating various OA stages, with efficient and sustained effects, suggesting rapid clinical adoption and high acceptability among clinicians and patients. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATF4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATF4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alpha-ketoglutarate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alpha-ketoglutarate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+reticulum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic reticulum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+Acid%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic Acid/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketoglutaric+Acids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketoglutaric Acids/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketoglutaric+Acids%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketoglutaric Acids/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Delayed-Action+Preparations%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Delayed-Action Preparations/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Zhang K</b>, Li S, Li J, Zhou X, Qin Y, Wu L, Ling J. Ultra-pH-sensitive nanoplatform for precise tumor therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122858. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366182' target='_blank'>39366182</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122858' target='_blank'>10.1016/j.biomaterials.2024.122858</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122858','39366182', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122858' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.biomaterials.2024.122858" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The emergence of precision cancer treatment has triggered a paradigm shift in the field of oncology, facilitating the implementation of more effective and personalized therapeutic approaches that enhance patient outcomes. The pH of the tumor microenvironment (TME) plays a pivotal role in both the initiation and progression of cancer, thus emerging as a promising focal point for precision cancer treatment. By specifically targeting the acidic conditions inherent to the tumor microenvironment, innovative therapeutic interventions have been proposed, exhibiting significant potential in augmenting treatment efficacy and ameliorating patient prognosis. The concept of ultra-pH-sensitive (UPS) nanoplatform was proposed several years ago, demonstrating exceptional pH sensitivity and an adjustable pH transition point. Subsequently, diverse UPS nanoplatforms have been actively explored for biomedical applications, enabling the loading of fluorophores, therapeutic drugs, and photosensitizers. This review aims to elucidate the design strategy and response mechanism of the UPS nanoplatform, with a specific emphasis on its applications in surgical therapy, immunotherapy, drug delivery, photodynamic therapy, and photothermal therapy. The potential and challenges of translating in the clinic on UPS nanoplatforms are finally explored. Thanks to its responsive and easily modifiable nature, the integration of multiple functional units within a UPS nanoplatform holds great promise for future advancements in tumor precision theranositcs. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fluorescence+guide+surgery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fluorescence guide surgery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ultra-pH+sensitive%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ultra-pH sensitive</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen-Ion+Concentration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen-Ion Concentration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photochemotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photochemotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Precision+Medicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Precision Medicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photosensitizing+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photosensitizing Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photosensitizing+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photosensitizing Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Zhang Z</b>, Li W, Zheng C, Chen K, Pang H, Shi W, Lu J. Insight into the bimetallic structure sensibility of catalytic nitrate reduction over Pd-Cu nanocrystals. <em class='incite-journal-name' onclick='ShowInCiteJournal(169368);'>J Environ Sci (China)</em> 2025;<b>149</b>:221-233. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39181637' target='_blank'>39181637</a> DOI: <a href='https://dx.doi.org/10.1016/j.jes.2024.01.011' target='_blank'>10.1016/j.jes.2024.01.011</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jes.2024.01.011','39181637', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jes.2024.01.011' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169368);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.jes.2024.01.011" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Catalytic reduction of nitrate over bimetallic catalysts has emerged as a technology for sustainable treatment of nitrate-containing groundwater. However, the structure of bimetallic has been much less investigated for catalyst optimization. Herein, two main types of Pd-Cu bimetallic nanocrystal structures, heterostructure and intermetallic, were prepared and characterized using high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The results show that two individual Pd and Cu nanocrystals with a mixed interface exist in the heterostructure nanocrystals, while Pd and Cu atoms are uniformly distributed across the intermetallic Pd-Cu nanocrystals. The catalytic nitrate reduction experiments were carried out in a semibatch reactor under constant hydrogen flow. The nitrate conversion rate of the heterostructure Pd-Cu nanocrystals supported on α-Al2O3, γ-Al2O3, SBA-15, and XC-72R exhibited 3.82-, 6.76-, 4.28-, 2.44-fold enhancements relative to the intermetallic nanocrystals, and the nitrogen and nitrite were the main products for the heterostructure and intermetallic Pd-Cu nanocrystals, respectively. This indicates that the catalytic nitrate reduction over Pd-Cu catalyst is sensitive to the bimetallic structures of the catalysts, and heterostructure bimetallic nanocrystals exhibit better catalytic performances on both the activity and selectivity, which may provide new insights into the design and optimization of catalysts to improve catalytic activity and selectivity for nitrate reduction in water. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Activity+and+selectivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Activity and selectivity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Catalytic+nitrate+reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Catalytic nitrate reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heterostructure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heterostructure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intermetallic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intermetallic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pd-Cu+bimetallic+catalyst%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pd-Cu bimetallic catalyst</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Catalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Catalysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Copper%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Copper/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Palladium%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Palladium/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nitrates%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nitrates/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal+Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Water+Pollutants%2c+Chemical%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Water Pollutants, Chemical/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Chemical%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Chemical</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Li T</b>, Li Q, Liu S, Cao J, Mei J, Gong J, Chen J, Wang X, Zhang R, Li X, Wang Q, Zhang H, Wang B, Cao H, Yang H, Fung SY. Targeted V-type peptide-decorated nanoparticles prevent colitis by inhibiting endosomal TLR signaling and modulating intestinal macrophage polarization. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122843. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39321686' target='_blank'>39321686</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122843' target='_blank'>10.1016/j.biomaterials.2024.122843</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122843','39321686', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122843' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.biomaterials.2024.122843" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inflammatory bowel disease (IBD) has become a serious and challenging health problem globally without curative medical treatments. Mounting evidence suggests that intestinal macrophages and their phenotypes are key players in the pathogenesis of IBD. Modulating the phenotypes and functions of intestinal macrophages through targeted interventions could be a promising approach to manage detrimental gut inflammation in IBD. In this study, we rationally design and fabricate a novel class of V-type peptide-decorated nanoparticles, VP-NP, with potent anti-inflammatory activity. Such a design allows two functional motifs FFD in a single peptide molecule to enhance the bioactivity of the nanoparticles. As expected, VP-NP exhibits a strong inhibitory activity on endosomal Toll-like receptor (TLR) signaling. Surprisingly, VP-NP can inhibit M1 polarization while facilitating M2 polarization in mouse bone marrow-derived macrophages through regulating the key transcription factors NF-κB, STAT1 and PPAR-γ. Mechanistically, VP-NP is internalized by macrophages in the endosomes, where it blocks endosomal acidification to inhibit endosomal TLR signaling; the transcriptomic analysis reveals that VP-NP potently down-regulates many genes in TLR, NF-κB, JAK-STAT, and cytokine/chemokine signaling pathways associated with inflammatory responses. In a colitis mouse model, the intraperitoneally administered VP-NP effectively alleviates the disease activities by decreasing colon inflammation and injuries, pro-inflammatory cytokine production, and myeloid cell infiltration in the gut. Furthermore, VP-NP primarily targets intestinal macrophages and alters their phenotypes from inflammatory M1-type toward the anti-inflammatory M2-type. This study provides a new nanotherapeutic strategy to specifically regulate macrophage activation and phenotypes through a dual mechanism to control gut inflammation, which may augment current clinical treatments for IBD. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+responses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory responses</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-like+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-like receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Hu L</b>, Li T, Deng S, Gao H, Jiang Y, Chen Q, Chen H, Xiao Z, Shuai X, Su Z. Tertiary lymphoid structure formation induced by LIGHT-engineered and photosensitive nanoparticles-decorated bacteria enhances immune response against colorectal cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122846. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39317142' target='_blank'>39317142</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122846' target='_blank'>10.1016/j.biomaterials.2024.122846</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122846','39317142', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122846' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/26/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.biomaterials.2024.122846" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Tertiary lymphoid structures (TLSs) are known to enhance the prognosis of patients with colorectal cancer (CRC) by fostering an immunologically active tumor microenvironment (TME). Inducing TLS formation therapeutically holds promise for treating immunologically cold CRC, though it poses technical challenges. Here, we design and fabricate a photosensitive bacterial system named E@L-P/ICG. This system is engineered bacteria internally loaded with the cytokine LIGHT and surface-modified with PLGA/ICG nanoparticles (P/ICG NPs). Once accumulated in orthotopic colonic tumors in mice, E@L-P/ICG generates a mild photothermal effect under laser irradiation due to the photosensitive P/ICG NPs. This photothermal effect triggers the self-rupture of E@L-P/ICG and the death of surrounding tumor cells to release adjuvants and antigens, respectively, which in turn synergistically activate the adaptive immune responses. Furthermore, the cytokine LIGHT released from ruptured E@L-P/ICG stimulates the generation of high endothelial vessels (HEVs), promoting lymphocyte recruitment within the TME. These mechanisms lead to the TLS formation in CRC, which further boosts adaptive immune responses through effective infiltration of T cells and B cells, resulting in effectively inhibited tumor growth and extended survival of mice. Our study shows the potential of the E@L-P/ICG system in photosensitively inducing the TLS formation to treat CRC in clinic. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Engineered+bacteria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Engineered bacteria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22High+endothelial+vessels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">High endothelial vessels</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tertiary+lymphoid+structures%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tertiary lymphoid structures</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colorectal+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colorectal Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tertiary+Lymphoid+Structures%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tertiary Lymphoid Structures/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photosensitizing+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photosensitizing Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photosensitizing+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photosensitizing Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Light%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Light</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Indocyanine+Green%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Indocyanine Green/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Ming P</b>, Li B, Li Q, Yuan L, Jiang X, Liu Y, Cai R, Zhou P, Lan X, Tao G, Xiao J. Multifunctional sericin-based biomineralized nanoplatforms with immunomodulatory and angio/osteo-genic activity for accelerated bone regeneration in periodontitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122885. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39423514' target='_blank'>39423514</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122885' target='_blank'>10.1016/j.biomaterials.2024.122885</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122885','39423514', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122885' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.biomaterials.2024.122885" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontitis is a chronic inflammation caused by dental plaque. It is characterized by the accumulation of excessive reactive oxygen species (ROS) and inflammatory mediators in the periodontal area. This affects the function of host cells, activates osteoclasts, and destroys periodontal tissue. Treatments such as local debridement or antibiotic therapy for ameliorating the overactive inflammatory microenvironment and repairing periodontal tissues are challenging. This paper reports multifunctional nanoplatforms (Se-CuSrHA@EGCG) based on sericin with ROS-scavenging, immunomodulatory, angiogenic, and osteogenic capabilities. The natural protein sericin, derived from silk cocoons, is used in water/oil emulsification and cross-linking processes to create sericin nanoparticles (Se NPs). Numerous binding sites are present on the surface of Se NPs. Ion-doped hydroxyapatite nanoparticles (Se-CuSrHA NPs) can be constructed using the force between positive and negative charges. After mineralization, an antioxidant coating is formed on the surface using polyethyleneimine (PEI)/epigallocatechin gallate (EGCG). Research conducted both in vitro and in vivo demonstrates that Se-CuSrHA@EGCG NPs can efficiently scavenge ROS, regulate macrophage polarization, increase the secretion of anti-inflammatory cytokines, and balance the immune microenvironment. In addition, Se-CuSrHA@EGCG stimulates angiogenesis, inhibits osteoclasts, and accelerates periodontal tissue repair. Therefore, this is a preferable strategy to accelerate bone regeneration in patients with periodontitis. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+mineralization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic mineralization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multifunctional+nanoplatforms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multifunctional nanoplatforms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontal+tissue+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontal tissue regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS-scavenging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS-scavenging</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sericin+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sericin nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sericins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sericins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sericins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sericins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunologic+Factors%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunologic Factors/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunologic+Factors%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunologic Factors/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunologic+Factors%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunologic Factors/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Physiologic%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Physiologic/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomineralization%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomineralization/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Lam W</b>, Yao Y, Tang C, Wang Y, Yuan Q, Peng L. Bifunctional mesoporous HMUiO-66-NH<sub>2</sub> nanoparticles for bone remodeling and ROS scavenging in periodontitis therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122872. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39383779' target='_blank'>39383779</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>10.1016/j.biomaterials.2024.122872</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122872','39383779', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.biomaterials.2024.122872" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontal bone defects represent an irreversible consequence of periodontitis associated with reactive oxygen species (ROS). However, indiscriminate removal of ROS proves to be counterproductive for tissue repair and insufficient for addressing existing bone defects. In the treatment of periodontitis, it is crucial to rationally alleviate local ROS while simultaneously promoting bone regeneration. In this study, Zr-based large-pore hierarchical mesoporous metal-organic framework (MOF) nanoparticles (NPs) HMUiO-66-NH2 were successfully proposed as bifunctional nanomaterials for bone regeneration and ROS scavenging in periodontitis therapy. HMUiO-66-NH2 NPs demonstrated outstanding biocompatibility both in vitro and in vivo. Significantly, these NPs enhanced the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) under normal and high ROS conditions, upregulating osteogenic gene expression and mitigating oxidative stress. Furthermore, in vivo imaging revealed a gradual degradation of HMUiO-66-NH2 NPs in periodontal tissues. Local injection of HMUiO-66-NH2 effectively reduced bone defects and ROS levels in periodontitis-induced C57BL/6 mice. RNA sequencing highlighted that differentially expressed genes (DEGs) are predominantly involved in bone tissue development, with notable upregulation in Wnt and TGF-β signaling pathways. In conclusion, HMUiO-66-NH2 exhibits dual functionality in alleviating oxidative stress and promoting bone repair, positioning it as an effective strategy against bone resorption in oxidative stress-related periodontitis. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bifunctional+nanomaterials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bifunctional nanomaterials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HMUiO-66-NH(2)+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HMUiO-66-NH(2) nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenic+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenic differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+scavenging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS scavenging</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a 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Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Remodeling%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Remodeling/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-Organic+Frameworks%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-Organic Frameworks/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-Organic+Frameworks%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-Organic Frameworks/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Porosity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Porosity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Free+Radical+Scavengers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Free Radical Scavengers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Guo Z</b>, Huang T, Lv X, Yin R, Wan P, Li G, Zhang P, Xiao C, Chen X. Tumor microenvironment-activated polypeptide nanoparticles for oncolytic immunotherapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122870. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39369669' target='_blank'>39369669</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122870' target='_blank'>10.1016/j.biomaterials.2024.122870</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122870','39369669', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122870' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.biomaterials.2024.122870" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cationic oncolytic polypeptides have gained increasing attention owing to their ability to directly lyse cancer cells and activate potent antitumor immunity. However, the low tumor cell selectivity and inherent toxicity induced by positive charges of oncolytic polypeptides hinder their systemic application. Herein, a tumor microenvironment-responsive nanoparticle (DNP) is developed by the self-assembly of a cationic oncolytic polypeptide (PLP) with a pH-sensitive anionic polypeptide via electrostatic interactions. After the formation of DNP, the positive charges of PLP are shielded. DNPs can keep stable in physiological conditions (pH 7.4) but respond to acidic tumor microenvironment (pH 6.8) to release oncolytic PLP. As a result, DNPs evoke potent immunogenic cell death by disrupting cell membranes, damaging mitochondria and increasing intracellular levels of reactive oxygen species. In vivo results indicate that DNPs significantly improve the biocompatibility of PLP, and inhibit tumor growth, recurrence and metastasis by direct oncolysis and activation of antitumor immune responses. In summary, these results indicate that pH-sensitive DNPs represent a prospective strategy to improve the tumor selectivity and biosafety of cationic polymers for oncolytic immunotherapy. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cationic+polypeptide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cationic polypeptide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunogenic+cell+death%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunogenic cell death</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oncolytic+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oncolytic therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pH-sensitivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pH-sensitivity</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen-Ion+Concentration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen-Ion Concentration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oncolytic+Virotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oncolytic Virotherapy/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Zheng R</b>, Zhu J, Liao P, Wang D, Wu P, Mao W, Zhang Y, Wang W. Environmental colloid behaviors of humic acid - Cadmium nanoparticles in aquatic environments. <em class='incite-journal-name' onclick='ShowInCiteJournal(169368);'>J Environ Sci (China)</em> 2025;<b>149</b>:663-675. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39181676' target='_blank'>39181676</a> DOI: <a href='https://dx.doi.org/10.1016/j.jes.2024.02.015' target='_blank'>10.1016/j.jes.2024.02.015</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jes.2024.02.015','39181676', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jes.2024.02.015' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169368);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.jes.2024.02.015" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Humic acid (HA), a principal constituent of natural organic matter (NOM), manifests ubiquitously across diverse ecosystems and can significantly influence the environmental behaviors of Cd(II) in aquatic systems. Previous studies on NOM-Cd(II) interactions have primarily focused on the immobilization of Cd(II) solids, but little is known about the colloidal stability of organically complexed Cd(II) particles in the environment. In this study, we investigated the formation of HA-Cd(II) colloids and quantified their aggregation, stability, and transport behaviors in a saturated porous media representative of typical subsurface conditions. Results from batch experiments indicated that the relative quantity of HA-Cd(II) colloids increased with increasing C/Cd molar ratio and that the carboxyl functional groups of HA dominated the stability of HA-Cd(II) colloids. The results of correlation analysis between particle size, critical aggregation concentration (CCC), and zeta potential indicated that both Derjaguin-Landau-Verwey-Overbeek (DLVO) and non-DLVO interactions contributed to the enhanced colloidal stability of HA-Cd(II) colloids. Column results further confirmed that the stable HA-Cd(II) colloid can transport fast in a saturated media composed of clean sand. Together, this study provides new knowledge of the colloidal behaviors of NOM-Cd(II) nanoparticles, which is important for better understanding the ultimate cycling of Cd(II) in aquatic systems. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colloid+aggregation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colloid aggregation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colloid+formation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colloid formation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HA-Cd(II)+colloids%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HA-Cd(II) colloids</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transport%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transport</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humic+Substances%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humic Substances/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cadmium%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cadmium/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colloids%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colloids/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Water+Pollutants%2c+Chemical%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Water Pollutants, Chemical/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Water+Pollutants%2c+Chemical%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Water Pollutants, Chemical/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal+Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Chemical%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Chemical</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Yu Y</b>, Jiang X, Yu T, Chen F, Huang R, Xun Z, Wang X, Liu X, Xie X, Sun C, Xu Y, Liu X, Sun H, Yuan X, Ma C, Li Y, Song X, Wang D, Shao D, Shi X, Cao L. Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122863. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366185' target='_blank'>39366185</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122863' target='_blank'>10.1016/j.biomaterials.2024.122863</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122863','39366185', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122863' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.biomaterials.2024.122863" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Sarcopenia is a progressive skeletal muscle disorder characterized by the accelerated loss of muscle mass and function, with no promising pharmacotherapies. Understanding the imbalance of myoprotein homeostasis within myotubes, which causes sarcopenia, may facilitate the development of novel treatments for clinical use. In this study, we found a strong correlation between low serum selenium levels and muscle function in elderly patients with sarcopenia. We hypothesized that supplementation with selenium might be beneficial for the management of sarcopenia. To verify this hypothesis, we developed diselenide-bridged mesoporous silica nanoparticles (Se-Se-MSNs) with ROS-responsive degradation and release to supplement selenium. Se-Se-MSNs outperformed free selenocysteine in alleviating sarcopenia in both dexamethasone (Dex)- and denervation-induced mouse models. Subsequently, Se-Se-MSNs were loaded with leucine (Leu@Se-Se-MSNs), another nutritional supplement used in sarcopenia management. Oral administration of Leu@Se-Se-MSNs restored myoprotein homeostasis by enhancing mTOR/S6K signaling and inactivating Akt/FoxO3a/MuRF1 signaling, thus exerting optimal therapeutic effects against sarcopenia and exhibiting a more favorable in vivo safety profile. This study provides a proof of concept for treating sarcopenia by maintaining myoprotein and redox homeostasis simultaneously and offers valuable insights into the development of multifunctional nanoparticle-based supplements for sarcopenia management. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leucine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leucine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myoprotein+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myoprotein homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sarcopenia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sarcopenia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Selenium%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Selenium</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sarcopenia%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sarcopenia/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Homeostasis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Homeostasis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dietary+Supplements%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dietary Supplements</a></li><li><a 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Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Qiu P</b>, Wen M, Zhuang Z, Niu S, Tao C, Yu N, Chen Z. Biomimetic polymeric nanoreactors with photooxidation-initiated therapies and reinvigoration of antigen-dependent and antigen-free immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122884. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39405823' target='_blank'>39405823</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122884' target='_blank'>10.1016/j.biomaterials.2024.122884</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122884','39405823', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122884' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.biomaterials.2024.122884" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Immune cell-mediated anticancer modalities usually suffer from immune cell exhaustion and limited efficacy in solid tumors. Herein, the oxygen-carrying biomimetic nanoreactors (BNR2(O2)) have been developed with photooxidation-driven therapies and antigen-dependent/antigen-free immune reinvigoration against xenograft tumors. The BNR2(O2) composes polymeric nanoreactors camouflaged with cancer cell membranes can efficiently target homotypic tumors. It continuously releases O2 to boost intracellular reactive oxygen species (ROS) to oxide diselenide bonds, which controllably releases seleninic acids and anti-folate Pemetrexed compared to hydrogen peroxide and glutathione incubation. The O2-rich microenvironment sensitizes Pemetrexed and blocks programmed cell-death ligand 1 (PD-L1) to reverse T cell immunosuppression. The ROS and Pemetrexed upregulate pro-apoptosis proteins and inhibit folate-related enzymes, which cause significant apoptosis and immunogenic cell death to stimulate dendritic cell maturation for improved secretion of cytokines, expanding antigen-dependent T cell immunity. Furthermore, by regulating the release of seleninic acids, the checkpoint receptor human leukocyte antigen E of tumor cells can be blocked to reinvigorate antigen-free natural killer cell immunity. This work offers an advanced antitumor strategy by bridging biomimetic nanoreactors and modulation of multiple immune cells. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diselenide+bond%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diselenide bond</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Membrane+camouflage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Membrane camouflage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoreactor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoreactor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Photooxidation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Photooxidation</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pemetrexed%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pemetrexed/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pemetrexed%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pemetrexed/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Mei T</b>, Zhang P, Hu Y, Xiao L, Hou J, Nagasaki Y. Engineering hirudin encapsulation in pH-responsive antioxidant nanoparticles for therapeutic efficacy in ischemic stroke model mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122860. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366183' target='_blank'>39366183</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122860' target='_blank'>10.1016/j.biomaterials.2024.122860</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122860','39366183', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122860' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.biomaterials.2024.122860" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study introduces a novel pH-sensitive, hirudin-loaded antioxidant nanoparticle (HD@iNanoAOX) aimed at addressing the challenges of hirudin's short half-life and hemorrhagic transformation. HD@iNanoAOX was engineered to safeguard and prolong hirudin's bioactivity by encapsulating it within antioxidative nanoparticles, facilitating its gradual release in acidic environments. The efficacy of this approach was validated through both ex vivo and in vivo experiments. Ex vivo thrombolytic assays demonstrated that HD@iNanoAOX maintained effective clot lysis activity under acidic conditions. In vivo assessments revealed that HD@iNanoAOX significantly prolonged hirudin's half-life and reduced cerebral infarct volume in a mouse model of middle cerebral artery occlusion (MCAO). Furthermore, HD@iNanoAOX treatment mitigated cerebral oxidative stress, suppressed hemorrhagic transformation, and prevented blood-brain barrier (BBB) disruption. These findings suggest that the combined thrombolytic and antioxidative properties of HD@iNanoAOX offer a promising therapeutic approach for ischemic stroke. Nonetheless, further research is warranted to optimize the formulation and assess its safety and efficacy in clinical settings. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antioxidants%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antioxidants/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hirudins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hirudins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hirudins%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hirudins/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen-Ion+Concentration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen-Ion Concentration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ischemic+Stroke%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ischemic Stroke/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infarction%2c+Middle+Cerebral+Artery%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infarction, Middle Cerebral Artery/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Kuan CH</b>, Chang L, Ho CY, Tsai CH, Liu YC, Huang WY, Wang YN, Wang WH, Wang TW. Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122848. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39342917' target='_blank'>39342917</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122848' target='_blank'>10.1016/j.biomaterials.2024.122848</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122848','39342917', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122848' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/01/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.biomaterials.2024.122848" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chronic wound healing often encounters challenges characterized by prolonged inflammation and impaired angiogenesis. While the immune response plays a pivotal role in orchestrating the intricate process of wound healing, excessive inflammation can hinder tissue repair. In this study, a bilayer alginate hydrogel system encapsulating polyelectrolyte complex nanoparticles (PCNs) loaded with anti-inflammatory cytokines and angiogenic growth factors is developed to address the challenges of chronic wound healing. The alginate hydrogel is designed using two distinct crosslinking methods to achieve differential degradation, thereby enabling precise spatial and temporal controlled release of PCNs. Initially, interleukin-10 (IL-10) is released to mitigate inflammation, while unsaturated PCNs bind and remove accumulated pro-inflammatory cytokines at the wound site. Subsequently, angiogenic growth factors, including vascular endothelial growth factor and platelet-derived growth factor, are released to promote vascularization and vessel maturation. Our results demonstrate that the bilayer hydrogel exhibits distinct degradation kinetics between the two layers, facilitating the staged release of multiple signaling molecules. In vitro experiments reveal that IL-10 can activate the Jak1/STAT3 pathway, thereby suppressing pro-inflammatory cytokines and chemokines while down-regulating inflammation-related genes. In vivo studies demonstrate that application of the hydrogel in chronic wounds using diabetic murine model promotes healing by positively modulating multiple integral reparative mechanisms. These include reducing inflammation, promoting macrophage polarization towards a pro-regenerative phenotype, enhancing keratinocyte migration, stimulating angiogenesis, and expediting wound closure. In conclusion, our hydrogel system effectively mitigates inflammatory responses and provides essential physiological cues by inducing a synergistic angiogenic effect, thus offering a promising approach for the treatment of chronic wounds. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Angiogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Angiogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chronic+wound+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chronic wound healing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogel</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polyelectrolyte+complex+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polyelectrolyte complex nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Physiologic%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Physiologic/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alginates%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alginates/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-10%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-10/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulating+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulating Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulating+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulating Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Angiogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Angiogenesis</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Li X</b>, Hua S, Zhong D, Zhou M, Ding Z. Metal-organic framework-edaravone nanoparticles for radiotherapy-induced brain injury treatment. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122868. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39413653' target='_blank'>39413653</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122868' target='_blank'>10.1016/j.biomaterials.2024.122868</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122868','39413653', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122868' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.biomaterials.2024.122868" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cranial radiotherapy may cause damage to normal brain tissues and induce cognitive dysfunction, so developing an effective strategy to prevent radiotherapy-induced brain injury is essential. Metal-organic frameworks (MOFs) can be used as vectors for the delivery of neuroprotective drugs due to their high drug loading capacity and low toxicity. In this study, we synthesized MIL-53(Cr) nanoparticles, which were used to deliver edaravone, and modified the surface of the nanoparticles with polyethylene glycol and Angiopep-2 (EDA@MIL-53(Cr)-P/A) to improve their oral bioavailability and ability to cross the blood-brain barrier (BBB). We confirmed that MIL-53(Cr)-P/A nanoparticles could achieve the sustained release of edaravone and enhance its ability to cross the BBB. The results of in vitro experiments showed that EDA@MIL-53(Cr)-P/A could exert radioprotective effects on HT22 and BV2 cells. We also demonstrated that EDA@MIL-53(Cr)-P/A could alleviate brain injury and cognitive dysfunction in mice receiving whole-brain irradiation. Mechanistically, EDA@MIL-53(Cr)-P/A alleviated irradiation-induced brain damage by inhibiting oxidative stress, DNA damage, apoptosis and inflammatory reactions. This study provides a new strategy for the protection against radiotherapy-induced brain injury. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+dysfunction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive dysfunction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-organic+framework%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-organic framework</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiotherapy</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-Organic+Frameworks%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-Organic Frameworks/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiation-Protective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiation-Protective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiation-Protective+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiation-Protective Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Yang Z</b>, Zhou Y, Liu X, Ren L, Liu X, Yun R, Jia L, Ren X, Wang Y, Sun Y, Li J, Gao D, Tian Z. Mitochondrial-uncoupling nanomedicine for self-heating and immunometabolism regulation in cancer cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122883. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39405827' target='_blank'>39405827</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122883' target='_blank'>10.1016/j.biomaterials.2024.122883</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122883','39405827', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122883' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.biomaterials.2024.122883" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Developing endogenous hyperthermia offers a promising strategy to address challenges with current exogenous hyperthermia techniques in clinics. Herein, a CD44-targeted and thermal-responsive nanocarrier was developed for the simultaneous delivery of 2,4-dinitrophenol and syrosingopine. The objective was to induce endogenous hyperthermia and regulate immunometabolism, ultimately augmenting anti-tumour immune responses. Dinitrophenol as mitochondrial uncoupler can convert electrochemical potential energy of inner mitochondrial membrane into heat, facilitating endogenous hyperthermia. Meanwhile, syrosingopine not only inhibits excessive lactate efflux caused by dinitrophenol but also downregulates tumour cell glycolysis, thus alleviating immunosuppression and heat shock protein (HSP)-dependent thermo-resistance through immunometabolism regulation. The synergistic effects of endogenous hyperthermia and immunometabolism regulation by this nanomedicine have potential to enhance tumor immunogenicity, reshape the tumour immune microenvironment, and effectively suppress the growth of subcutaneous tumours and patient-derived organoids in triple-negative breast cancer. Therefore, the endogenous hyperthermia strategy developed in this study would revolutionize hyperthermia for cancer treatment. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endogenous+hyperthermia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endogenous hyperthermia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunometabolism+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunometabolism regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanomedicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanomedicine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thermo-sensitivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thermo-sensitivity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Upper+critical+solution+temperature%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Upper critical solution temperature</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanomedicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanomedicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyperthermia%2c+Induced%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyperthermia, Induced</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%222%2c4-Dinitrophenol%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2,4-Dinitrophenol/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Uncoupling+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Uncoupling Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+BALB+C%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred BALB C</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Das S</b>, Yadav GD. Tailored design of novel Co<sup>0</sup>-Co<sup>δ+</sup> dual phase nanoparticles for selective CO<sub>2</sub> hydrogenation to ethanol. <em class='incite-journal-name' onclick='ShowInCiteJournal(169368);'>J Environ Sci (China)</em> 2025;<b>149</b>:598-615. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39181671' target='_blank'>39181671</a> DOI: <a href='https://dx.doi.org/10.1016/j.jes.2024.01.047' target='_blank'>10.1016/j.jes.2024.01.047</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.jes.2024.01.047','39181671', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.jes.2024.01.047' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169368);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.jes.2024.01.047" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Catalytic hydrogenation of CO2 to ethanol is a promising solution to address the greenhouse gas (GHG) emissions, but many current catalysts face efficiency and cost challenges. Cobalt based catalysts are frequently examined due to their abundance, cost-efficiency, and effectiveness in the reaction, where managing the Co0 to Coδ+ ratio is essential. In this study, we adjusted support nature (Al2O3, MgO-MgAl2O4, and MgO) and reduction conditions to optimize this balance of Co0 to Coδ+ sites on the catalyst surface, enhancing ethanol production. The selectivity of ethanol reached 17.9% in a continuous flow fixed bed micro-reactor over 20 mol% Co@MgO-MgAl2O4 (CoMgAl) catalyst at 270 °C and 3.0 MPa, when reduced at 400 °C for 8 h. Characterisation results coupled with activity analysis confirmed that mild reduction condition (400 °C, 10% H2 balance N2, 8 h) with intermediate metal support interaction favoured the generation of partially reduced Co sites (Coδ+ and Co0 sites in single atom) over MgO-MgAl2O4 surface, which promoted ethanol synthesis by coupling of dissociative (CHx*)/non-dissociative (CHxO*) intermediates, as confirmed by density functional theory analysis. Additionally, the CoMgAl, affordably prepared through the coprecipitation method, offers a potential alternative for CO2 hydrogenation to yield valuable chemicals. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CO(2)+hydrogenation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CO(2) hydrogenation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Co-based+catalysts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Co-based catalysts</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DFT+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DFT analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ethanol%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ethanol</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal+support+ineraction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal support ineraction</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carbon+Dioxide%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carbon Dioxide/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ethanol%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ethanol/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogenation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogenation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cobalt%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cobalt/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Catalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Catalysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Chemical%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Chemical</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Liu Y</b>, Yu D, Ge X, Huang L, Pan PY, Shen H, Pettigrew RI, Chen SH, Mai J. Novel platinum therapeutics induce rapid cancer cell death through triggering intracellular ROS storm. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122835. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39276409' target='_blank'>39276409</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560510' target='_blank'>PMC11560510</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122835' target='_blank'>10.1016/j.biomaterials.2024.122835</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122835','39276409', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(23);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122835' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.biomaterials.2024.122835" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Induction of reactive oxygen species (ROS) production in cancer cells plays a critical role for cancer treatment. However, therapeutic efficiency remains challenging due to insufficient ROS production of current ROS inducers. We designed a novel platinum (Pt)-based drug named "carrier-platin" that integrates ultrasmall Pt-based nanoparticles uniformly confined within a poly(amino acids) carrier. Carrier-platin dramatically triggered a burst of ROS in cancer cells, leading to cancer cell death as quick as 30 min. Unlike traditional Pt-based drugs which induce cell apoptosis through DNA intercalation, carrier-platin with superior ROS catalytic activities induces a unique pattern of cancer cell death that is neither apoptosis nor ferroptosis and operates independently of DNA damage. Importantly, carrier-platin demonstrates superior anti-tumor efficacy against a broad spectrum of cancers, particularly those with multidrug resistance, while maintaining minimal systemic toxicity. Our findings reveal a distinct mechanism of action of Pt in cancer cell eradication, positioning carrier-platin as a novel category of anti-cancer chemotherapeutics. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Platinum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Platinum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+oxygen+species%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive oxygen species</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Platinum%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Platinum/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Platinum%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Platinum/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Death%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Death/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Carriers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Carriers/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA222959 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Poudel K</b>, Vithiananthan T, Kim JO, Tsao H. Recent progress in cancer vaccines and nanovaccines. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122856. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366184' target='_blank'>39366184</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122856' target='_blank'>10.1016/j.biomaterials.2024.122856</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122856','39366184', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122856' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.biomaterials.2024.122856" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Vaccine science, nanotechnology, and immunotherapy are at the forefront of cancer treatment strategies, each offering significant potential for enhancing tumor-specific immunity and establishing long-lasting immune memory to prevent tumor recurrence. Despite the promise of these personalized and precision-based anti-cancer approaches, challenges such as immunosuppression, suboptimal immune activation, and T-cell exhaustion continue to hinder their effectiveness. The limited clinical success of cancer vaccines often stems from difficulties in identifying effective antigens, efficiently targeting immune cells, lymphoid organs, and the tumor microenvironment, overcoming immune evasion, enhancing immunogenicity, and avoiding lysosomal degradation. However, numerous studies have demonstrated that integrating nanotechnology with immunotherapeutic strategies in vaccine development can overcome these challenges, leading to potent antitumor immune responses and significant progress in the field. This review highlights the critical components of cancer vaccine and nanovaccine strategies for immunomodulatory antitumor therapy. It covers general vaccine strategies, types of vaccines, antigen forms, nanovaccine platforms, challenges faced, potential solutions, and key findings from preclinical and clinical studies, along with future perspectives. To fully unlock the potential of cancer vaccines and nanovaccines, precise immunological monitoring during early-phase trials is essential. This approach will help identify and address obstacles, ultimately expanding the available options for patients who are resistant to conventional cancer immunotherapies. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanovaccines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanovaccines</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vaccines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vaccines</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+Vaccines%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer Vaccines/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanotechnology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanotechnology/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanovaccines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanovaccines</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Pang X</b>, Zhang T, Li J, Yu L, Liu Z, Liu Y, Li L, Cheng L, Zhu R. LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122873. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39369670' target='_blank'>39369670</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122873' target='_blank'>10.1016/j.biomaterials.2024.122873</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122873','39369670', 'Nanoparticles/chemistry')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122873' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1016/j.biomaterials.2024.122873" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Spinal cord injury (SCI) triggers interconnected malignant pathological cascades culminating in structural abnormalities and composition changes of neural tissues and impairs spinal cord tissue function. Cellulose nanofibers (CNF) have considerable potential in mimicking tissue microstructure for nerve regeneration, but the effectiveness of CNF in repairing SCI remains poorly understood. In this study, we designed a Mg-Fe layered double hydroxide (LDH)-doped cellulose nanofiber (CNF) scaffold with aligned intact microchannels and homogeneously distributed pores (CNF-LDH), loaded with retinoic acid and sonic hedgehog (CNF-LDH-RS) for neuroregeneration. The aligned microchannel structure and chemical cues in the scaffold were designed further to enhance the differentiation of neural stem cells towards neurons and promote axon growth while inhibiting differentiation to astrocytes. Transplanting the scaffolds into a completely transected SCI mice model dramatically improved behavioral and electrophysiological outcomes underpinned by robust neuronal regeneration, significant axonal growth and orderly neural circuit remodeling. RNA-seq analysis revealed the pivotal roles of the RhoA/Rock/Myosin II pathway and neuroactive ligand-receptor interaction pathway in SCI repair by CNF-LDH-RS. Particularly, Myosin II emerged as a key gene for functional recovery, and its effect on negative regulation of axon growth was suppressed by the scaffolds, resulting in a distinctly oriented growth of the axons along the microchannel structure. The results indicate that CNF-LDH scaffolds rationally combined with physical and biochemical cues create promising tissue-engineered substrates to facilitate the repair of spinal cord injury. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aligned+microchannels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aligned microchannels</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellulose+nanofiber%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellulose nanofiber</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myosin+II%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myosin II</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+cord+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal cord injury</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanofibers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanofibers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Scaffolds%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Scaffolds/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rho-Associated+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rho-Associated Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellulose%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellulose/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rhoA+GTP-Binding+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rhoA GTP-Binding Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+Cord+Injuries%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal Cord Injuries/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+Cord+Injuries%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal Cord Injuries/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myosin+Type+II%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myosin Type II/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a 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id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Nanoparticles/chemistry (29797 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Nanoparticles/chemistry (29797 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>