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RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" 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Anti-pyroptosis biomimetic nanoplatform loading puerarin for myocardial infarction repair: From drug discovery to drug delivery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122890. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39427429' target='_blank'>39427429</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122890' target='_blank'>10.1016/j.biomaterials.2024.122890</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122890','39427429', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122890' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.biomaterials.2024.122890" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pyroptosis is a critical pathological mechanism implicated in myocardial damage following myocardial infarction (MI), and the crosstalk between macrophages and pyroptotic cardiomyocytes presents a formidable challenge for anti-pyroptosis therapies of MI. However, as single-target pyroptosis inhibitors frequently fail to address this crosstalk, the efficacy of anti-pyroptosis treatment post-MI remains inadequate. Therefore, the exploration of more potent anti-pyroptosis approaches is imperative for improving outcomes in MI treatment, particularly in addressing the crosstalk between macrophages and pyroptotic cardiomyocytes. Here, in response to this crosstalk, we engineered an anti-pyroptosis biomimetic nanoplatform (NM@PDA@PU), employing polydopamine (PDA) nanoparticles enveloped with neutrophil membrane (NM) for targeted delivery of puerarin (PU). Notably, network pharmacology is deployed to discern the most efficacious anti-pyroptosis drug (puerarin) among the 7 primary active monomers of TCM formulations widely applied in clinical practice and reveal the effect of puerarin on the crosstalk. Additionally, targeted delivery of puerarin could disrupt the malignant crosstalk between macrophages and pyroptotic cardiomyocytes, and enhance the effect of anti-pyroptosis by not only directly inhibiting cardiomyocytes pyroptosis through NLRP3-CASP1-IL-1β/IL-18 signal pathway, but reshaping the inflammatory microenvironment by reprogramming macrophages to anti-inflammatory M2 subtype. Overall, NM@PDA@PU could enhance anti-pyroptosis effect by disrupting the crosstalk between M1 macrophages and pyroptotic cardiomyocytes to protect cardiomyocytes, ameliorate cardiac function and improve ventricular remodeling, which providing new insights for the efficient treatment of MI. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crosstalk%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crosstalk</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardial+infarction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardial infarction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Network+pharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Network pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Puerarin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Puerarin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Isoflavones%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Isoflavones/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pyroptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pyroptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocardial+Infarction%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocardial Infarction/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myocytes%2c+Cardiac%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myocytes, Cardiac/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Indoles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Indoles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+Materials%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic Materials/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Bhansali D</b>, Tu NH, Inoue K, Teng S, Li T, Tran HD, Kim DH, Dong J, Peach CJ, Sokrat B, Jensen DD, Dolan JC, Yamano S, Robinson VM, Bunnett NW, Albertson DG, Leong KW, Schmidt BL. PAR<sub>2</sub> on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122874. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39418848' target='_blank'>39418848</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122874' target='_blank'>10.1016/j.biomaterials.2024.122874</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122874','39418848', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(2);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122874' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1016/j.biomaterials.2024.122874" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR2, encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral cancer pain. PAR2 is a G protein-coupled receptor (GPCR) expressed on neurons and cells in the cancer microenvironment. Sustained signaling of PAR2 from endosomes of neurons mediates sensitization and nociception. We focused on the differential contribution of PAR2 on oral cancer cells and neurons to oral cancer pain and whether encapsulation of a PAR2 inhibitor, AZ3451 in nanoparticles (NP) more effectively reverses PAR2 activation. We report that F2RL1 was overexpressed in human oral cancers and cancer cell lines. Deletion of F2RL1 on cancer cells reduced cancer-associated mechanical allodynia. A third-generation polyamidoamine dendrimer, functionalized with cholesterol was self-assembled into NPs encapsulating AZ3451. NP encapsulated AZ3451 (PAMAM-Chol-AZ NPs) more effectively reversed activation of PAR2 at the plasma membrane and early endosomes than free drug. The PAMAM-Chol-AZ NPs showed greater efficacy in reversing nociception than free drug, with respect to both level and duration, in three preclinical mouse models of oral cancer pain. The antinociceptive efficacy was confirmed with an operant orofacial assay. Genetic deletion of F2RL1 on cancer cells or F2rl1 on neurons each partially reversed mechanical cancer allodynia. The remaining nociception could be effectively reversed by PAMAM-Chol-AZ NPs. These findings suggest that PAR2 on oral cancer cells and neurons contribute to oral cancer nociception and NPs loaded with a PAR2 antagonist provide increased antinociception and improved oral function compared to free drug. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+cancer+pain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral cancer pain</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PAR(2)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PAR(2)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Protease-activated+receptor+2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Protease-activated receptor 2</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Receptor%2c+PAR-2%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Receptor, PAR-2/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mouth+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mouth Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+Pain%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer Pain/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nociceptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nociceptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nociceptors%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nociceptors/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDCR+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DE029694 NIDCR NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Jin Z</b>, Zhang Y, Hu H, Li Q, Zhang L, Zhao K, Liu W, Li L, Gao C. Closed-loop theranostic microgels for immune microenvironment modulation and microbiota remodeling in ulcerative colitis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122834. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39288617' target='_blank'>39288617</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122834' target='_blank'>10.1016/j.biomaterials.2024.122834</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122834','39288617', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122834' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.biomaterials.2024.122834" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inflammatory bowel disease (IBD) is characterized by the upregulation of reactive oxygen species (ROS) and dysfunction of gut immune system, and microbiota. The conventional treatments mainly focus on symptom control with medication by overuse of drugs. There is an urgent need to develop a closed-loop strategy that combines in situ monitoring and precise treatment. Herein, we innovatively designed the 'cluster munition structure' theranostic microgels to realize the monitoring and therapy for ulcerative colitis (a subtype of IBD). The superoxide anion specific probe (tetraphenylethylene-coelenterazine, TPC) and ROS-responsive nanogels consisting of postbiotics urolithin A (UA) were loaded into alginate and ion-crosslinked to obtain the theranostic microgels. The theranostic microgels could be delivered to the inflammatory site, where the environment-triggered breakup of the microgels and release of the nanogels were achieved in sequence. The TPC-UA group had optimal results in reducing inflammation, repairing colonic epithelial tissue, and remodeling microbiota, leading to inflammation amelioration and recovery of tight junction between the colonic epithelium, and maintenance of gut microbiota. During the recovery process, the local chemiluminescence intensity, which is proportional to the degree of inflammation, was gradually inhibited. The cluster munition of theranostic microgels displayed promising outcomes in monitoring inflammation and precise therapy, and demonstrated the potential for inflammatory disease management. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oral+administration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oral administration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Postbiotics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Postbiotics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+monitoring%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS monitoring</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22theranostic+microgels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">theranostic microgels</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Theranostic+Nanomedicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Theranostic Nanomedicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microgels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microgels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Kim HL</b>, Saravanakumar G, Lee S, Jang S, Kang S, Park M, Sobha S, Park SH, Kim SM, Lee JA, Shin E, Kim YJ, Jeong HS, Kim D, Kim WJ. Poly(β-amino ester) polymer library with monomer variation for mRNA delivery. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122896. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39426123' target='_blank'>39426123</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122896' target='_blank'>10.1016/j.biomaterials.2024.122896</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122896','39426123', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122896' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1016/j.biomaterials.2024.122896" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Non-viral vectors for mRNA delivery primarily include lipid nanoparticles (LNPs) and polymers. While LNPs are known for their high mRNA delivery efficiency, they can induce excessive immune responses and cause off-target effects, potentially leading to side effects. In this study, we aimed to explore polymer-based mRNA delivery systems as a viable alternative to LNPs, focusing on their mRNA delivery efficiency and potential application in mRNA vaccines. We created a library of poly(β-amino ester) (PBAE) polymers by combining various amine monomers and acrylate monomers. Through screening this polymer library, we identified specific polymer nanoparticles (PNPs) that demonstrated high mRNA expression efficiency, with sustained mRNA expression for up to two weeks. Furthermore, the PNPs showed mRNA expression only at the injection site and did not exhibit liver toxicity. Additionally, when assessing immune activation, the PNPs significantly induced T-cell immune activation and were effective in the plaque reduction neutralization test. These results suggest that polymer-based mRNA delivery systems not only hold potential for use in mRNA vaccines but also show promise for therapeutic applications. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Poly(%ce%b2-amino+ester)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Poly(β-amino ester)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymer+library%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymer library</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymer+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymer nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+vaccine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA vaccine</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Transfer+Techniques%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Transfer Techniques</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Li C</b>, Fang F, Wang E, Yang H, Yang X, Wang Q, Si L, Zhang Z, Liu X. Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122832. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39270628' target='_blank'>39270628</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122832' target='_blank'>10.1016/j.biomaterials.2024.122832</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122832','39270628', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122832' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1016/j.biomaterials.2024.122832" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Extracellular vesicles (EVs) secreted by endothelial cells in response to blood laminar flow play a crucial role in maintaining vascular homeostasis. However, the potential of these EVs to modulate the immune microenvironment within plaques for treating atherosclerosis remains unclear. Here, we present compelling evidence that EVs secreted by endothelial cells sheared by atheroprotective laminar shear stress (LSS-EVs) exhibit excellent immunoregulatory effects against atherosclerosis. LSS-EVs demonstrated a robust capacity to induce the conversion of M1-type macrophages into M2-type macrophages. Mechanistic investigations confirmed that LSS-EVs were enriched in miR-34c-5p and reprogrammed macrophages by targeting the TGF-β-Smad3 signaling pathway. Moreover, we employed click chemistry to modify hyaluronic acid (HA) on the surface of LSS-EVs, enabling specific binding to the CD44 receptor expressed by inflammatory macrophages within plaques. These HA-modified LSS-EVs (HA@LSS-EVs) exhibited exceptional abilities for targeting atherosclerosis and demonstrated promising therapeutic effects both in vitro and in vivo. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+vesicles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular vesicles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Laminar+shear+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Laminar shear stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage reprogramming</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Vesicles%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Vesicles/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atherosclerosis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atherosclerosis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+Acid%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic Acid/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+Acid%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic Acid/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellular+Reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellular Reprogramming</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endothelial Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Human+Umbilical+Vein+Endothelial+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Human Umbilical Vein Endothelial Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Mechanical%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Mechanical</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transforming+Growth+Factor+beta%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transforming Growth Factor beta/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Huang Y</b>, Xu J, Sun G, Cheng X, An Y, Yao X, Nie G, Zhang Y. Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122822. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39270625' target='_blank'>39270625</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122822' target='_blank'>10.1016/j.biomaterials.2024.122822</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122822','39270625', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122822' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1016/j.biomaterials.2024.122822" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Reactive oxygen species (ROS) play crucial roles in the pathogenesis of inflammatory bowel disease (IBD) by disrupting the mucosal barrier and subsequently leading to the dysregulation of the gut microbiome. Therefore, ROS scavengers present a promising and comprehensive strategy for the effective IBD treatment. In the current work, we explored the therapeutic potential of cerium dioxide (CeO2) nano-enzyme, which is well-known for their potent antioxidant properties and capability to mimic natural antioxidant enzymes in the regulation of oxidative stress. We developed a novel enteric-coated nanomedicine (CeO2@S100) aiming at improving the oral delivery efficacy of CeO2 in the complex gastrointestinal environment. CeO2@S100 is composed of a CeO2 nanoparticle core and a protective polyacrylic acid resin shell (Eudragit S100), ensuring targeted delivery of the core specifically at inflamed intestinal sites due to the negative surface charge. In vivo experiments revealed CeO2@S100 significantly alleviates the IBD by balancing oxidative stress and regulating gut microbiota in a dextran sulfate sodium-induced mouse colitis model. The uncomplicated synthesis of CeO2@S100 highlights its promise for clinical use, presenting an effective and safe approach to managing IBD. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CeO(2)+nano-enzyme%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CeO(2) nano-enzyme</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eudragit+S100%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eudragit S100</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+microbiota+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal microbiota regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+scavenger%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS scavenger</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerium%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerium/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cerium%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cerium/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidation-Reduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidation-Reduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dextran+Sulfate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dextran Sulfate</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Ghosh S</b>, Zheng M, He J, Wu Y, Zhang Y, Wang W, Shen J, Yeung KWK, Neelakantan P, Xu C, Qiao W. Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122908. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39454504' target='_blank'>39454504</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122908' target='_blank'>10.1016/j.biomaterials.2024.122908</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122908','39454504', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122908' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1016/j.biomaterials.2024.122908" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Fungal infections affect over 13 million people worldwide and are responsible for 1.5 million deaths annually. Some deep cutaneous fungal infections may extend the dermal barriers to cause systemic infection, resulting in substantial morbidity and mortality. However, the management of deep cutaneous fungal infection is challenging and yet overlooked by traditional treatments, which only offer limited drug availability within deep tissue. In this study, we have developed an electrically stimulated microneedle patch to deliver miconazole into the subcutaneous layer. We tested its antifungal efficacy using in vitro and ex vivo models that mimic fungal infection. Moreover, we confirmed its anti-fungal and wound-healing effects in a murine subcutaneous fungal infection model. Furthermore, our findings also showed that the combination of miconazole and applied current synergistically stimulated the nociceptive sensory nerves, thereby activating protective cutaneous immunity mediated by dermal dendritic and γδ-T cells. Collectively, this study provides a new strategy for minimally invasive delivery of therapeutic agents and the modulation of the neuro-immune axis in deep tissue. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electroconductive+microneedle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electroconductive microneedle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infected+wound+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infected wound healing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neuro-immune+crosstalk%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neuro-immune crosstalk</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Needles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Needles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antifungal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antifungal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Miconazole%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Miconazole/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Miconazole%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Miconazole/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Skin%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Skin/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electric+Conductivity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electric Conductivity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dermatomycoses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dermatomycoses</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Wang X</b>, Xue Y, Hao K, Peng B, Chen H, Liu H, Wang J, Cao J, Dong W, Zhang S, Yang Q, Li J, Lei W, Feng Y. Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122845. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39326362' target='_blank'>39326362</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122845' target='_blank'>10.1016/j.biomaterials.2024.122845</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122845','39326362', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122845' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1016/j.biomaterials.2024.122845" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Osteoarthritis (OA) is a prevalent degenerative disease characterized by irreversible destruction of articular cartilage, for which no current drugs are known to modify its progression. While intra-articular (IA) injections of hyaluronic acid (HA) offer temporary relief, their effectiveness and long-term benefits are debated. Alpha-ketoglutarate (αKG) has potential chondroprotective properties, but its use is limited by a short half-life and poor cartilage-targeting efficiency. Here, we developed self-assembled HA-αKG nanoparticles (NPs) to combine the benefits of both HA and αKG, showing stability, bioavailability, and sustained pH-responsive release in the knee joint. In both early and advanced OA stages in mice, HA, αKG, and HA-αKG NPs could relieve pain, enhance mobility, and reduce cartilage damage, with HA-αKG NPs demonstrating the best efficacy. Mechanistically, αKG not only promotes cartilage matrix synthesis but also inhibits degradation by activating the PERK-ATF4 signaling pathway to reduce endoplasmic reticulum stress (ERS) in chondrocytes. This study highlights the therapeutic potential of HA-αKG NPs for treating various OA stages, with efficient and sustained effects, suggesting rapid clinical adoption and high acceptability among clinicians and patients. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ATF4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ATF4</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alpha-ketoglutarate%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alpha-ketoglutarate</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endoplasmic+reticulum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endoplasmic reticulum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+acid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic acid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronic+Acid%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronic Acid/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketoglutaric+Acids%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketoglutaric Acids/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ketoglutaric+Acids%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ketoglutaric Acids/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cartilage%2c+Articular%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cartilage, Articular/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Delayed-Action+Preparations%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Delayed-Action Preparations/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Mahanty M</b>, Dutta B, Ou W, Zhu X, Bromberg JS, He X, Rahaman SO. Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122855. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39362025' target='_blank'>39362025</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560625' target='_blank'>PMC11560625</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122855' target='_blank'>10.1016/j.biomaterials.2024.122855</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122855','39362025', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122855' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.biomaterials.2024.122855" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Host recognition and immune-mediated foreign body response (FBR) to biomaterials can adversely affect the functionality of implanted materials. FBR presents a complex bioengineering and medical challenge due to the lack of current treatments, making the detailed exploration of its molecular mechanisms crucial for developing new and effective therapies. To identify key molecular targets underlying the generation of FBR, here we perform analysis of microRNAs (miR) and mRNAs responses to implanted biomaterials. We found that (a) miR-146a levels inversely affect macrophage accumulation, foreign body giant cell (FBGC) formation, and fibrosis in a murine implant model; (b) macrophage-derived miR-146a is a crucial regulator of the FBR and FBGC formation, as confirmed by global and cell-specific knockout of miR-146a; (c) miR-146a modulates genes related to inflammation, fibrosis, and mechanosensing; (d) miR-146a modulates tissue stiffness near the implant during FBR as assessed by atomic force microscopy; and (e) miR-146a is linked to F-actin production and cellular traction force induction as determined by traction force microscopy, which are vital for FBGC formation. These novel findings suggest that targeting macrophage miR-146a could be a selective strategy to inhibit FBR, potentially improving the biocompatibility of biomaterials. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomaterials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomaterials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foreign+body+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foreign body response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Giant+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Giant cell</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miR-146a%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miR-146a</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foreign-Body+Reaction%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foreign-Body Reaction/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biocompatible+Materials%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biocompatible Materials/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Giant+Cells%2c+Foreign-Body%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Giant Cells, Foreign-Body/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prostheses+and+Implants%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prostheses and Implants/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibrosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibrosis</a></li></ul> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAID+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 AI172086 NIAID NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Li H</b>, Ma L, Zhu N, Liang X, Tian X, Liu K, Fu X, Wang X, Zhang H, Chen H, Liu Q, Yang J. Mesenchymal stromal cells surface engineering for efficient hematopoietic reconstitution. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122882. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39423513' target='_blank'>39423513</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122882' target='_blank'>10.1016/j.biomaterials.2024.122882</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122882','39423513', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122882' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1016/j.biomaterials.2024.122882" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Mesenchymal stromal cells (MSCs) are believed to migrate to injury sites, release chemical attractants, and either recruit local stem cells or modulate the immune system positively. Although MSCs are highly desired for their potential to reduce inflammation and promote tissue regeneration, their limited lifespan restricts their applications. This study presents a simple approach for protecting MSCs with epigallocatechin-3-gallate (EGCG) and magnesium (Mg) based metal-organic framework coatings (E-Mg@MSC). The layer strengthens MSCs resistant to harmful stresses and creates a favorable microenvironment for repair by providing Mg to facilitate MSCs' osteogenic differentiation and using EGCG to neutralize excessive reactive oxygen species (ROS). E-Mg@MSC serves as a treatment for hematopoietic injury induced by ionizing radiation (IR). Coated MSCs exhibit sustained secretion of hematopoietic growth factors and precise homing to radiation-sensitive tissues. In vivo studies show substantial enhancement in hematopoietic system recovery and multi-organ protection. Mechanistic investigations suggest that E-Mg@MSC mitigates IR-induced ROS, cell apoptosis, and ferroptosis, contributing to reduced radiation damage. The system represents a versatile and compelling strategy for cell-surface engineering with functional materials to advance MSCs therapy. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell-surface+engineering%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell-surface engineering</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematopoietic+reconstitution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematopoietic reconstitution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+stromal+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal stromal cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-organic+frameworks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-organic frameworks</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Catechin%2fanalogs+%26amp%3b+derivatives%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Catechin/analogs & derivatives</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Catechin%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Catechin/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Magnesium%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Magnesium/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hematopoiesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hematopoiesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-Organic+Frameworks%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-Organic Frameworks/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-Organic+Frameworks%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-Organic Frameworks/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Li T</b>, Li Q, Liu S, Cao J, Mei J, Gong J, Chen J, Wang X, Zhang R, Li X, Wang Q, Zhang H, Wang B, Cao H, Yang H, Fung SY. Targeted V-type peptide-decorated nanoparticles prevent colitis by inhibiting endosomal TLR signaling and modulating intestinal macrophage polarization. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122843. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39321686' target='_blank'>39321686</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122843' target='_blank'>10.1016/j.biomaterials.2024.122843</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122843','39321686', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122843' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1016/j.biomaterials.2024.122843" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Inflammatory bowel disease (IBD) has become a serious and challenging health problem globally without curative medical treatments. Mounting evidence suggests that intestinal macrophages and their phenotypes are key players in the pathogenesis of IBD. Modulating the phenotypes and functions of intestinal macrophages through targeted interventions could be a promising approach to manage detrimental gut inflammation in IBD. In this study, we rationally design and fabricate a novel class of V-type peptide-decorated nanoparticles, VP-NP, with potent anti-inflammatory activity. Such a design allows two functional motifs FFD in a single peptide molecule to enhance the bioactivity of the nanoparticles. As expected, VP-NP exhibits a strong inhibitory activity on endosomal Toll-like receptor (TLR) signaling. Surprisingly, VP-NP can inhibit M1 polarization while facilitating M2 polarization in mouse bone marrow-derived macrophages through regulating the key transcription factors NF-κB, STAT1 and PPAR-γ. Mechanistically, VP-NP is internalized by macrophages in the endosomes, where it blocks endosomal acidification to inhibit endosomal TLR signaling; the transcriptomic analysis reveals that VP-NP potently down-regulates many genes in TLR, NF-κB, JAK-STAT, and cytokine/chemokine signaling pathways associated with inflammatory responses. In a colitis mouse model, the intraperitoneally administered VP-NP effectively alleviates the disease activities by decreasing colon inflammation and injuries, pro-inflammatory cytokine production, and myeloid cell infiltration in the gut. Furthermore, VP-NP primarily targets intestinal macrophages and alters their phenotypes from inflammatory M1-type toward the anti-inflammatory M2-type. This study provides a new nanotherapeutic strategy to specifically regulate macrophage activation and phenotypes through a dual mechanism to control gut inflammation, which may augment current clinical treatments for IBD. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-Inflammatory+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-Inflammatory nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+responses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory responses</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+polarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage polarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-like+receptor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-like receptor</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Endosomes%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Endosomes/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Toll-Like+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Toll-Like Receptors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestines%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestines/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Polarity%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Polarity/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Lam W</b>, Yao Y, Tang C, Wang Y, Yuan Q, Peng L. Bifunctional mesoporous HMUiO-66-NH<sub>2</sub> nanoparticles for bone remodeling and ROS scavenging in periodontitis therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122872. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39383779' target='_blank'>39383779</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>10.1016/j.biomaterials.2024.122872</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122872','39383779', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122872' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1016/j.biomaterials.2024.122872" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Periodontal bone defects represent an irreversible consequence of periodontitis associated with reactive oxygen species (ROS). However, indiscriminate removal of ROS proves to be counterproductive for tissue repair and insufficient for addressing existing bone defects. In the treatment of periodontitis, it is crucial to rationally alleviate local ROS while simultaneously promoting bone regeneration. In this study, Zr-based large-pore hierarchical mesoporous metal-organic framework (MOF) nanoparticles (NPs) HMUiO-66-NH2 were successfully proposed as bifunctional nanomaterials for bone regeneration and ROS scavenging in periodontitis therapy. HMUiO-66-NH2 NPs demonstrated outstanding biocompatibility both in vitro and in vivo. Significantly, these NPs enhanced the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) under normal and high ROS conditions, upregulating osteogenic gene expression and mitigating oxidative stress. Furthermore, in vivo imaging revealed a gradual degradation of HMUiO-66-NH2 NPs in periodontal tissues. Local injection of HMUiO-66-NH2 effectively reduced bone defects and ROS levels in periodontitis-induced C57BL/6 mice. RNA sequencing highlighted that differentially expressed genes (DEGs) are predominantly involved in bone tissue development, with notable upregulation in Wnt and TGF-β signaling pathways. In conclusion, HMUiO-66-NH2 exhibits dual functionality in alleviating oxidative stress and promoting bone repair, positioning it as an effective strategy against bone resorption in oxidative stress-related periodontitis. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bifunctional+nanomaterials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bifunctional nanomaterials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HMUiO-66-NH(2)+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HMUiO-66-NH(2) nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenic+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenic differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ROS+scavenging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ROS scavenging</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Periodontitis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Periodontitis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mesenchymal+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mesenchymal Stem 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class="article-citation"> <b>Yu Y</b>, Jiang X, Yu T, Chen F, Huang R, Xun Z, Wang X, Liu X, Xie X, Sun C, Xu Y, Liu X, Sun H, Yuan X, Ma C, Li Y, Song X, Wang D, Shao D, Shi X, Cao L. Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122863. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366185' target='_blank'>39366185</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122863' target='_blank'>10.1016/j.biomaterials.2024.122863</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122863','39366185', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122863' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.biomaterials.2024.122863" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Sarcopenia is a progressive skeletal muscle disorder characterized by the accelerated loss of muscle mass and function, with no promising pharmacotherapies. Understanding the imbalance of myoprotein homeostasis within myotubes, which causes sarcopenia, may facilitate the development of novel treatments for clinical use. In this study, we found a strong correlation between low serum selenium levels and muscle function in elderly patients with sarcopenia. We hypothesized that supplementation with selenium might be beneficial for the management of sarcopenia. To verify this hypothesis, we developed diselenide-bridged mesoporous silica nanoparticles (Se-Se-MSNs) with ROS-responsive degradation and release to supplement selenium. Se-Se-MSNs outperformed free selenocysteine in alleviating sarcopenia in both dexamethasone (Dex)- and denervation-induced mouse models. Subsequently, Se-Se-MSNs were loaded with leucine (Leu@Se-Se-MSNs), another nutritional supplement used in sarcopenia management. Oral administration of Leu@Se-Se-MSNs restored myoprotein homeostasis by enhancing mTOR/S6K signaling and inactivating Akt/FoxO3a/MuRF1 signaling, thus exerting optimal therapeutic effects against sarcopenia and exhibiting a more favorable in vivo safety profile. This study provides a proof of concept for treating sarcopenia by maintaining myoprotein and redox homeostasis simultaneously and offers valuable insights into the development of multifunctional nanoparticle-based supplements for sarcopenia management. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leucine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leucine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myoprotein+homeostasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myoprotein homeostasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sarcopenia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sarcopenia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Selenium%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Selenium</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reactive+Oxygen+Species%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reactive Oxygen Species/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Li Y</b>, Lv J, Liu S, Wang Z, Gao Y, Fan Z, Huang L, Cui J, Zhang B, Liu X, Zhang Z, Liu T, Li D, Yang M. Macrophage corpses for immunoregulation and targeted drug delivery in treatment of collagen-induced arthritis mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122867. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366181' target='_blank'>39366181</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122867' target='_blank'>10.1016/j.biomaterials.2024.122867</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122867','39366181', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122867' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1016/j.biomaterials.2024.122867" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The role of pro-inflammatory macrophages (M1) in rheumatoid arthritis (RA) is significant, as they produce excessive cytokines. Targeting efferocytosis is a potential manner to repolarize M1 macrophages into pro-resolving M2 phenotype, which restores immune homeostasis by releasing anti-inflammatory mediators. In this study, liquid nitrogen-treated dead macrophages (DM) are employed to act as a dead cell-derived active targeted drug carrier for shikonin (SHK) and induce efferocytosis in M1 macrophages with the enhancement of SHK as an AMP-activated protein kinase (AMPK)-activator. The synergistic activation of AMPK leads to uncoupled protein 2 (UCP2) upregulation and reprograms M1 macrophages into M2 phenotypes by promoting oxidative phosphorylation. In the mouse model of collagen-induced arthritis, the intravenous administration of DM/SHK leads to a consistent transformation of M1 macrophages into the M2 phenotype within the infiltrative synovium. This transformation of macrophages results in the restoration of immune homeostasis in the synovium through an increase in the production of pro-resolving mediators. Additionally, it inhibits synovial proliferation and infiltration and provides protection against erosion of cartilage and bone. In summary, LNT-based DM serves as an active targeting drug carrier to M1 macrophages and also acts synergistically with SHK to target immunometabolism. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Efferocytosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Efferocytosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunometabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunometabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liquid+nitrogen-treated+cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liquid nitrogen-treated cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophage+repolarization%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophage repolarization</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rheumatoid arthritis</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Experimental%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Experimental/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Naphthoquinones%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Naphthoquinones/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Naphthoquinones%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Naphthoquinones/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Arthritis%2c+Rheumatoid%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Arthritis, Rheumatoid/pathology</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Long D</b>, Deng Z, Zhao X, Xu Y, Li W, Mo X, Zhong Y, Li M, He A, Zhang Z, Kang Y, Mao G. m<sup>7</sup>G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122903. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39454503' target='_blank'>39454503</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122903' target='_blank'>10.1016/j.biomaterials.2024.122903</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122903','39454503', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122903' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/28/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.biomaterials.2024.122903" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">N7-methylguanosine (m7G) modification is one of the most prevalent RNA modifications, and methyltransferase-like protein-1 (METTL1) is a key component of the m7G methyltransferase complex. METTL1-catalyzed m7G as a new RNA modification pathway that regulates RNA structure, biogenesis, and cell migration. Increasing evidence indicates that m7G modification has been implicated in the pathophysiological process of osteoarthritis (OA). However, the underlying molecular mechanisms of m7G modification remains incompletely elucidated during the progression of OA. Here we found that METTL1 and m7G levels were markedly increased in OA chondrocytes. In addition, METTL1-mediated m7G modification upregulated mt-tRF3b-LeuTAA expression to exacerbate chondrocyte degeneration. Mechanistically, mt-tRF3b-LeuTAA decreased the SUMO-specific protease 1 (SENP1) protein expression and upregulated the level of sirtuin 3 (SIRT3) SUMOylation to inhibit PTEN induced kinase 1 (PINK1)/Parkin-mediated mitochondrial mitophagy. Intra-articular injection of PMC-tRF3b-LeuTAA inhibitor (Polyamidoamine-polyethylene glycol surface-modified with Minimal self-peptides and Chondrocyte-affinity peptides, PMC) attenuated destabilization of the medial meniscus (DMM) mouse cartilage degeneration in vivo. Our study demonstrates that METTL1/m7G/mt-tRF3b-LeuTAA axis accelerate cartilage degradation by inhibiting mitophagy and promoting mitochondrial dysfunction through SIRT3 SUMOylation, and suggest that targeting METTL1 and its downstream signaling axis could be a promising therapeutic target for OA treatment. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic reprogramming</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22N7-methylguanosine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">N7-methylguanosine</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tRNA-derived+fragments%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tRNA-derived fragments</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chondrocytes%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chondrocytes/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitophagy%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitophagy/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methyltransferases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methyltransferases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sumoylation%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sumoylation/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sirtuin+3%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sirtuin 3/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sirtuin+3%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sirtuin 3/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteoarthritis%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteoarthritis/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metabolic+Reprogramming%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metabolic Reprogramming</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metallothionein+3%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metallothionein 3</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Mei T</b>, Zhang P, Hu Y, Xiao L, Hou J, Nagasaki Y. Engineering hirudin encapsulation in pH-responsive antioxidant nanoparticles for therapeutic efficacy in ischemic stroke model mice. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122860. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39366183' target='_blank'>39366183</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122860' target='_blank'>10.1016/j.biomaterials.2024.122860</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122860','39366183', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122860' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/06/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.biomaterials.2024.122860" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">This study introduces a novel pH-sensitive, hirudin-loaded antioxidant nanoparticle (HD@iNanoAOX) aimed at addressing the challenges of hirudin's short half-life and hemorrhagic transformation. HD@iNanoAOX was engineered to safeguard and prolong hirudin's bioactivity by encapsulating it within antioxidative nanoparticles, facilitating its gradual release in acidic environments. The efficacy of this approach was validated through both ex vivo and in vivo experiments. Ex vivo thrombolytic assays demonstrated that HD@iNanoAOX maintained effective clot lysis activity under acidic conditions. In vivo assessments revealed that HD@iNanoAOX significantly prolonged hirudin's half-life and reduced cerebral infarct volume in a mouse model of middle cerebral artery occlusion (MCAO). Furthermore, HD@iNanoAOX treatment mitigated cerebral oxidative stress, suppressed hemorrhagic transformation, and prevented blood-brain barrier (BBB) disruption. These findings suggest that the combined thrombolytic and antioxidative properties of HD@iNanoAOX offer a promising therapeutic approach for ischemic stroke. Nonetheless, further research is warranted to optimize the formulation and assess its safety and efficacy in clinical settings. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antioxidants%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antioxidants/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hirudins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hirudins/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hirudins%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hirudins/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen-Ion+Concentration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen-Ion Concentration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ischemic+Stroke%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ischemic Stroke/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infarction%2c+Middle+Cerebral+Artery%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infarction, Middle Cerebral Artery/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Kuan CH</b>, Chang L, Ho CY, Tsai CH, Liu YC, Huang WY, Wang YN, Wang WH, Wang TW. Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122848. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39342917' target='_blank'>39342917</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122848' target='_blank'>10.1016/j.biomaterials.2024.122848</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122848','39342917', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122848' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/01/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1016/j.biomaterials.2024.122848" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Chronic wound healing often encounters challenges characterized by prolonged inflammation and impaired angiogenesis. While the immune response plays a pivotal role in orchestrating the intricate process of wound healing, excessive inflammation can hinder tissue repair. In this study, a bilayer alginate hydrogel system encapsulating polyelectrolyte complex nanoparticles (PCNs) loaded with anti-inflammatory cytokines and angiogenic growth factors is developed to address the challenges of chronic wound healing. The alginate hydrogel is designed using two distinct crosslinking methods to achieve differential degradation, thereby enabling precise spatial and temporal controlled release of PCNs. Initially, interleukin-10 (IL-10) is released to mitigate inflammation, while unsaturated PCNs bind and remove accumulated pro-inflammatory cytokines at the wound site. Subsequently, angiogenic growth factors, including vascular endothelial growth factor and platelet-derived growth factor, are released to promote vascularization and vessel maturation. Our results demonstrate that the bilayer hydrogel exhibits distinct degradation kinetics between the two layers, facilitating the staged release of multiple signaling molecules. In vitro experiments reveal that IL-10 can activate the Jak1/STAT3 pathway, thereby suppressing pro-inflammatory cytokines and chemokines while down-regulating inflammation-related genes. In vivo studies demonstrate that application of the hydrogel in chronic wounds using diabetic murine model promotes healing by positively modulating multiple integral reparative mechanisms. These include reducing inflammation, promoting macrophage polarization towards a pro-regenerative phenotype, enhancing keratinocyte migration, stimulating angiogenesis, and expediting wound closure. In conclusion, our hydrogel system effectively mitigates inflammatory responses and provides essential physiological cues by inducing a synergistic angiogenic effect, thus offering a promising approach for the treatment of chronic wounds. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Angiogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Angiogenesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chronic+wound+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chronic wound healing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogel</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polyelectrolyte+complex+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polyelectrolyte complex nanoparticles</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neovascularization%2c+Physiologic%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neovascularization, Physiologic/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alginates%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alginates/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RAW+264.7+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RAW 264.7 Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytokines%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytokines/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Interleukin-10%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Interleukin-10/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulating+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulating Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunomodulating+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunomodulating Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Angiogenesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Angiogenesis</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Li X</b>, Hua S, Zhong D, Zhou M, Ding Z. Metal-organic framework-edaravone nanoparticles for radiotherapy-induced brain injury treatment. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122868. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39413653' target='_blank'>39413653</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122868' target='_blank'>10.1016/j.biomaterials.2024.122868</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122868','39413653', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122868' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.biomaterials.2024.122868" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Cranial radiotherapy may cause damage to normal brain tissues and induce cognitive dysfunction, so developing an effective strategy to prevent radiotherapy-induced brain injury is essential. Metal-organic frameworks (MOFs) can be used as vectors for the delivery of neuroprotective drugs due to their high drug loading capacity and low toxicity. In this study, we synthesized MIL-53(Cr) nanoparticles, which were used to deliver edaravone, and modified the surface of the nanoparticles with polyethylene glycol and Angiopep-2 (EDA@MIL-53(Cr)-P/A) to improve their oral bioavailability and ability to cross the blood-brain barrier (BBB). We confirmed that MIL-53(Cr)-P/A nanoparticles could achieve the sustained release of edaravone and enhance its ability to cross the BBB. The results of in vitro experiments showed that EDA@MIL-53(Cr)-P/A could exert radioprotective effects on HT22 and BV2 cells. We also demonstrated that EDA@MIL-53(Cr)-P/A could alleviate brain injury and cognitive dysfunction in mice receiving whole-brain irradiation. Mechanistically, EDA@MIL-53(Cr)-P/A alleviated irradiation-induced brain damage by inhibiting oxidative stress, DNA damage, apoptosis and inflammatory reactions. This study provides a new strategy for the protection against radiotherapy-induced brain injury. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain injury</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+dysfunction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive dysfunction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-organic+framework%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-organic framework</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiotherapy</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metal-Organic+Frameworks%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metal-Organic Frameworks/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Injuries%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Injuries/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Edaravone%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Edaravone/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Blood-Brain+Barrier%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Blood-Brain Barrier/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxidative+Stress%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxidative Stress/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiation-Protective+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiation-Protective Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiation-Protective+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiation-Protective Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peptides%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peptides</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Liu N</b>, Yan M, Lu C, Tao Q, Wu J, Zhou Z, Chen J, Chen X, Peng C. Eravacycline improves the efficacy of anti-PD1 immunotherapy via AP1/CCL5 mediated M1 macrophage polarization in melanoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122815. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39288620' target='_blank'>39288620</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122815' target='_blank'>10.1016/j.biomaterials.2024.122815</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122815','39288620', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122815' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1016/j.biomaterials.2024.122815" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Screening approved library is a promising and safe strategy to overcome the limitation of low response rate and drug resistance in immunotherapy. Accumulating evidence showed that the application of antibiotics has been considered to reduce the effectiveness of anti-PD1 immunotherapy in tumor treatment, however, in this study, an antibiotic drug (Eravacycline, ERV) was identified to improve the efficacy of anti-PD1 immunotherapy in melanoma through screening approved library. Administration of ERV significantly attenuated melanoma cells growth as well as directly or indirectly benefited M1 macrophage polarization. Meanwhile, ERV treatment significantly induced cellular autophagy via damage of mitochondria, leading to up-regulation of ROS production, subsequently, raised CCL5 secretion through elevation AP1 binding to CCL5 promoter via p38 or JNK1/2 activation. Knockdown of Ccl5 expression attenuated ERV triggered M1 macrophage polarization in melanoma cells. Clinical analysis revealed a positive association between high expression of CCL5 and improved prognosis as well as a favorable anti-PD1 therapy in melanoma patients. As expected, application of ERV improved the efficacy of anti-PD1. Overall, our results approved that ERV enhances the efficacy of anti-PD1 immunotherapy in melanoma by promoting the polarization of M1 macrophages, which provided novel therapeutic strategy for improving the effectiveness of melanoma anti-PD1 immunotherapy. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-PD1+immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-PD1 immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CCL5%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CCL5</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eravacycline%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eravacycline</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22M1+macrophage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">M1 macrophage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Melanoma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Melanoma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemokine+CCL5%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemokine CCL5/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macrophages%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macrophages/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factor+AP-1%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factor AP-1/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Programmed+Cell+Death+1+Receptor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Programmed Cell Death 1 Receptor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Programmed+Cell+Death+1+Receptor%2fantagonists+%26amp%3b+inhibitors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Programmed Cell Death 1 Receptor/antagonists & inhibitors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-fos%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-fos</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Pang X</b>, Zhang T, Li J, Yu L, Liu Z, Liu Y, Li L, Cheng L, Zhu R. LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122873. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39369670' target='_blank'>39369670</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122873' target='_blank'>10.1016/j.biomaterials.2024.122873</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122873','39369670', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122873' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.biomaterials.2024.122873" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Spinal cord injury (SCI) triggers interconnected malignant pathological cascades culminating in structural abnormalities and composition changes of neural tissues and impairs spinal cord tissue function. Cellulose nanofibers (CNF) have considerable potential in mimicking tissue microstructure for nerve regeneration, but the effectiveness of CNF in repairing SCI remains poorly understood. In this study, we designed a Mg-Fe layered double hydroxide (LDH)-doped cellulose nanofiber (CNF) scaffold with aligned intact microchannels and homogeneously distributed pores (CNF-LDH), loaded with retinoic acid and sonic hedgehog (CNF-LDH-RS) for neuroregeneration. The aligned microchannel structure and chemical cues in the scaffold were designed further to enhance the differentiation of neural stem cells towards neurons and promote axon growth while inhibiting differentiation to astrocytes. Transplanting the scaffolds into a completely transected SCI mice model dramatically improved behavioral and electrophysiological outcomes underpinned by robust neuronal regeneration, significant axonal growth and orderly neural circuit remodeling. RNA-seq analysis revealed the pivotal roles of the RhoA/Rock/Myosin II pathway and neuroactive ligand-receptor interaction pathway in SCI repair by CNF-LDH-RS. Particularly, Myosin II emerged as a key gene for functional recovery, and its effect on negative regulation of axon growth was suppressed by the scaffolds, resulting in a distinctly oriented growth of the axons along the microchannel structure. The results indicate that CNF-LDH scaffolds rationally combined with physical and biochemical cues create promising tissue-engineered substrates to facilitate the repair of spinal cord injury. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aligned+microchannels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aligned microchannels</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellulose+nanofiber%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellulose nanofiber</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myosin+II%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myosin II</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+regeneration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve regeneration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+cord+injury%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal cord injury</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanofibers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanofibers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nerve+Regeneration%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nerve Regeneration/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Scaffolds%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Scaffolds/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rho-Associated+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rho-Associated Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cellulose%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cellulose/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rhoA+GTP-Binding+Protein%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rhoA GTP-Binding Protein/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+Cord+Injuries%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal Cord Injuries/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spinal+Cord+Injuries%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spinal Cord Injuries/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Myosin+Type+II%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Myosin Type II/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanoparticles%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanoparticles/chemistry</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neural+Stem+Cells%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neural Stem Cells/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neural+Stem+Cells%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neural Stem Cells/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Guo Y</b>, Wang F, Wan S, Liu X, Huang Y, Xie M, Wei X, Zhu W, Yao T, Li Y, Zhang C, Zhu Y. Endothelium-targeted NF-κB siRNA nanogel for magnetic resonance imaging and visualized-anti-inflammation treatment of atherosclerosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122897. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39437581' target='_blank'>39437581</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122897' target='_blank'>10.1016/j.biomaterials.2024.122897</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122897','39437581', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122897' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/15/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.biomaterials.2024.122897" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Atherosclerosis-induced lethal cardiovascular disease remains a severe healthcare threat due to the limited drug efficiency and untimely prediction of high-risk events caused by inadequate target specificity of medications, incapable recognition of insensitive patients, and variable morphology of vulnerable plaques. Therefore, it is necessary to develop efficient strategies to improve the diagnosis accuracy and achieve visualized treatment of atherosclerosis. Herein, we establish an inflamed endothelium-targeted three-in-one nucleic acid nanogel system that can reverse the inflammatory state of endothelial cells (ECs) in plaques and simultaneously achieve real-time monitoring of the therapy process for efficient atherosclerosis diagnosis and treatment. For this purpose, contrast agent (Gd-DOTA) and VCAM-1-targeted peptide (VP) are first covalently conjugated onto DNA strands by click reaction respectively, which could self-assemble into Y-shaped structures (Gd-Y1 and VP-Y2 motifs) with magnetic resonance (MR) imaging and endothelium targeting capacities. Thereafter, NF-κB subunit p65-targeting siRNA (siNF-κB) is crosslinked with Gd-Y1 and VP-Y2 motifs to construct the endothelium-targeting nanogel platform. With contrast agents inside, the nanogel enables MR-based diagnosis and visualized therapy of atherosclerosis, providing accurate prognostic analysis and indications for treatment results, which ensures timely disclosure of insensitive individuals and avoids acute lethal events. By delivering siNF-κB to inflammatory endothelium, the nanogel significantly regresses plaques in both the aorta and carotid artery with reduced inflammation cytokines, collagens, macrophages, and apoptotic cells, providing a potential anti-inflammation strategy to treat atherosclerosis and avoid acute cardiovascular disease. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-inflammation+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-inflammation therapy</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heterocyclic+Compounds%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heterocyclic Compounds</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Organometallic+Compounds%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Organometallic Compounds</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Novak CM</b>, Wheat JS, Ghadiali SN, Ballinger MN. Mechanomemory of pulmonary fibroblasts demonstrates reversibility of transcriptomics and contraction phenotypes. <em class='incite-journal-name' onclick='ShowInCiteJournal(3556);'>Biomaterials</em> 2025;<b>314</b>:122830. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39276408' target='_blank'>39276408</a> DOI: <a href='https://dx.doi.org/10.1016/j.biomaterials.2024.122830' target='_blank'>10.1016/j.biomaterials.2024.122830</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biomaterials.2024.122830','39276408', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biomaterials.2024.122830' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3556);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/17/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1016/j.biomaterials.2024.122830" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Fibroblasts are cells responsible for producing extracellular matrix (ECM) components, which provides physical support for organs. Although these mesenchymal cells are responsive to mechanical cues in their environment, the permanence of these mechanophenotypes is not well defined. We investigated the mechanomemory of lung fibroblasts and determined how switching culture conditions modulate cell responses and function. Primary murine lung fibroblasts were isolated and cultured on 2D tissue culture plates or within 3D collagen hydrogels and were then passaged within the same or opposite culture condition to assess changes in gene expression, protein production, fibroblast subpopulation, contractile behavior, and traction forces. Compared to fibroblasts isolated on 2D tissue culture plates, fibroblasts within 3D hydrogels exhibited a decreased activation phenotype including reduced contraction profiles, diminished cell traction forces and decreased αSMA gene expression. Cells initially isolated via 2D culture and then cultured in 3D hydrogels exhibited a reversal in activation phenotype as measured by gene expression and contraction profiles. Bulk RNAseq identified groups of genes that exhibit reversible and non-reversable expression patterns. Overall, these findings indicate that lung fibroblasts have a mechanical memory that is altered by culture condition and can be reversible through precondition of cells within a softer 3D microenvironment. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%223D+culture%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">3D culture</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Collagen+hydrogel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Collagen hydrogel</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+matrix%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular matrix</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mechanomemory%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mechanomemory</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fibroblasts%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fibroblasts/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung%2fcytology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung/cytology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phenotype%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phenotype</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogels%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogels/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cells%2c+Cultured%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cells, Cultured</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Extracellular+Matrix%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Extracellular Matrix/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Culture+Techniques%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Culture Techniques/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mechanotransduction%2c+Cellular%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mechanotransduction, Cellular</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Lahogue C</b>, Boulouard M, Menager F, Freret T, Billard JM, Bouet V. A new 2-hit model combining serine racemase deletion and maternal separation displays behavioral and cognitive deficits associated with schizophrenia. <em class='incite-journal-name' onclick='ShowInCiteJournal(3378);'>Behav Brain Res</em> 2025;<b>477</b>:115301. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39442565' target='_blank'>39442565</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbr.2024.115301' target='_blank'>10.1016/j.bbr.2024.115301</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbr.2024.115301','39442565', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbr.2024.115301' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3378);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.bbr.2024.115301" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Schizophrenia (SCZ) is a multifactorial psychotic disorder characterized by positive and negative symptoms as well as cognitive impairments. To advance the current treatments, it is important to improve animal models by considering the multifactorial etiology, thus by combining different risk factors. The objective of our study was to explore in a new mouse model, the impact of genetic deletion of serine racemase (genetic vulnerability) combined with an early stress factor induced by maternal separation (early environmental exposure) in the context of SCZ development. The face validity of the model was assessed through a wide range of behavioral experiments. The 2-hit mice displayed an increased locomotor activity mimicking positive symptoms, working memory impairment, cognitive deficits and recognition memory alterations, which could reflect neophobia. This new multifactorial model therefore presents an interesting phenotype for modelling animal model with partial behavioral and cognitive deficits associated with SCZ. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maternal+separation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maternal separation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memory%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memory</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiple-hit%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiple-hit</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Psychosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Psychosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Serine+racemase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Serine racemase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schizophrenia%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schizophrenia/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Racemases+and+Epimerases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Racemases and Epimerases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Racemases+and+Epimerases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Racemases and Epimerases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maternal+Deprivation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maternal Deprivation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Dysfunction%2fetiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Dysfunction/etiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cognitive+Dysfunction%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cognitive Dysfunction/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Memory%2c+Short-Term%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Memory, Short-Term/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Recognition%2c+Psychology%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Recognition, Psychology/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schizophrenic+Psychology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schizophrenic Psychology</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Hu W</b>, Jiang L, Wang Q, Hu Q, Zhong T, Wu J, Chen X, Liu T. Chronic unpredictable stress during adolescence exerts sex-specific effects on depressive-like behavior and neural activation triggered by tail suspension test. <em class='incite-journal-name' onclick='ShowInCiteJournal(3378);'>Behav Brain Res</em> 2025;<b>477</b>:115314. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39461371' target='_blank'>39461371</a> DOI: <a href='https://dx.doi.org/10.1016/j.bbr.2024.115314' target='_blank'>10.1016/j.bbr.2024.115314</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bbr.2024.115314','39461371', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.bbr.2024.115314' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3378);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/29/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1016/j.bbr.2024.115314" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">During adolescence, acute stress can modify neuronal excitability in various brain regions, leading to negative behavioral outcomes. However, the impact of chronic stress during adolescence on neuronal responses to acute stimuli remains unclear. To address this, we subjected adolescent mice to 12 days of chronic unpredictable stress (CUS). Anxiety and depressive behaviors were evaluated, along with changes in c-Fos expression, which is one of the most widely used markers of neuronal activation. By comparing c-Fos immunoreactivity between the CUS and control groups both before and after the tail suspension test (TST), we found that adolescent CUS induced depressive behaviors in male mice, but not in female mice. Adolescent CUS primarily affected the excitability of neurons in the infralimbic cortex (IL), the dorsomedial and dorsolateral area of the bed nucleus of the stria terminalis (BNST), and the ventral hippocampus CA3. TST exerted a significant main effect on the density of c-Fos+ neurons in the prelimbic cortex (PL), infralimbic cortex (IL), cingulate areas 1 and 2 (Cg1, Cg2), the lateral septum (LS), BNST, and lateral habenular (LHb). Furthermore, the excitability of neurons in the paraventricular thalamic nucleus (PVT) was impacted by sex. These data suggest that adolescent CUS elicits region- and sex-specific modifications in TST-induced c-Fos expression, establishing a theoretical basis for understanding the pathophysiological alterations in mood disorders following adolescent stress. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22C-Fos%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">C-Fos</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chronic+unpredictable+stress%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chronic unpredictable stress</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+differences%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex differences</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stress%2c+Psychological%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stress, Psychological/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neurons%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neurons/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-fos%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-fos/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hindlimb+Suspension%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hindlimb Suspension</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Behavior%2c+Animal%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Behavior, Animal/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+Characteristics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex Characteristics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Models%2c+Animal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Models, Animal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxiety%2fphysiopathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxiety/physiopathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anxiety%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anxiety/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sex+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sex Factors</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Arbogast F</b>, Sal-Carro R, Boufenghour W, Frenger Q, Bouis D, Filippi De La Palavesa L, Fauny JD, Griso O, Puccio H, Fima R, Huby T, Gautier EL, Molitor A, Carapito R, Bahram S, Romani N, Clausen BE, Voisin B, Mueller CG, Gros F, Flacher V. Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism. <em class='incite-journal-name' onclick='ShowInCiteJournal(13273);'>J Cell Biol</em> 2025;<b>224</b>:e202403178. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39535446' target='_blank'>39535446</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561468' target='_blank'>PMC11561468</a> DOI: <a href='https://dx.doi.org/10.1083/jcb.202403178' target='_blank'>10.1083/jcb.202403178</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1083/jcb.202403178','39535446', 'Mice, Inbred C57BL')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1083/jcb.202403178' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13273);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1083/jcb.202403178" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Macroautophagy (often-named autophagy), a catabolic process involving autophagy-related (Atg) genes, prevents the accumulation of harmful cytoplasmic components and mobilizes energy reserves in long-lived and self-renewing cells. Autophagy deficiency affects antigen presentation in conventional dendritic cells (DCs) without impacting their survival. However, previous studies did not address epidermal Langerhans cells (LCs). Here, we demonstrate that deletion of either Atg5 or Atg7 in LCs leads to their gradual depletion. ATG5-deficient LCs showed metabolic dysregulation and accumulated neutral lipids. Despite increased mitochondrial respiratory capacity, they were unable to process lipids, eventually leading them to ferroptosis. Finally, metabolically impaired LCs upregulated proinflammatory transcripts and showed decreased expression of neuronal interaction receptors. Altogether, autophagy represents a critical regulator of lipid storage and metabolism in LCs, allowing their maintenance in the epidermis. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Langerhans+Cells%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Langerhans Cells/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lipid+Metabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lipid Metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epidermis%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epidermis/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein+7%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein 7/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein+7%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein 7/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein+5%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein 5/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Autophagy-Related+Protein+5%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Autophagy-Related Protein 5/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Inbred+C57BL%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Inbred C57BL</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Knockout%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Knockout</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mitochondria%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mitochondria/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(25);" 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class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Mice, Inbred C57BL (188701 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Mice, Inbred C57BL (188701 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>