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cyst</title> <meta name="description" content="Search results for: ovarian cyst"> <meta name="keywords" content="ovarian cyst"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="ovarian cyst"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 197</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: ovarian cyst</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">197</span> Endometrioma Ethanol Sclerotherapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lamia%20Bensissaid">Lamia Bensissaid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Goals: Endometriosis affects 6 to 10% of women of childbearing age. 17 to 44% of them have ovarian endometriomas. Medical and surgical treatments represent the two therapeutic axes with which PMA can be associated. Laparoscopic intraperitoneal ovarian cystectomy is described as the reference technique in the management of endometriomas by learned societies (CNGOF, ESHRE, NICE). However, it leads to a significant short-term reduction in the AMH level and the number of antral follicles, especially in cases of bilateral cystectomy, large cyst size or cystectomy after recurrence. Often, the disease is at an advanced stage with several surgical patients. Most have adhesions, which increase the risk of surgical complications and suboptimal resection and, therefore recurrence of the cyst. These results led to a change of opinion towards a conservative approach. Sclerotherapy is an old technique which acts by fibrinoid necrosis. It consists of injecting a sclerosing agent into the cyst cavity. Results : Recurrence was less than 15% for a 12-month follow-up; these rates are comparable to those of surgery. It does not seem to have a negative impact on ovarian reserve, but this is not sufficiently evaluated. It has an advantage in IVF pregnancy rates compared to cystectomy, particularly in cases of recurrent endometriomas. It has the advantages: · To be done on an outpatient basis. · To be inexpensive. · To avoid sometimes difficult and iterative surgery: · To allow an increase in pregnancy rates and the preservation of the ovarian reserve compared to iterative surgery. · of great interest in cases of bilateral endometriomas (kissing ovaries) or recurrent endometriomas. Conclusions: Ethanol sclerotherapy could be a good alternative to surgery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Endometrioma" title="Endometrioma">Endometrioma</a>, <a href="https://publications.waset.org/abstracts/search?q=Sclerotherapy" title=" Sclerotherapy"> Sclerotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=infertility" title=" infertility"> infertility</a>, <a href="https://publications.waset.org/abstracts/search?q=Ethanol" title=" Ethanol"> Ethanol</a> </p> <a href="https://publications.waset.org/abstracts/176251/endometrioma-ethanol-sclerotherapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/176251.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">64</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">196</span> Precocious Puberty Due to an Autonomous Ovarian Cyst in a 3-Year-Old Girl: Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aleksandra%20Cha%C5%82upnik">Aleksandra Chałupnik</a>, <a href="https://publications.waset.org/abstracts/search?q=Zuzanna%20Chilimoniuk"> Zuzanna Chilimoniuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Joanna%20Borowik"> Joanna Borowik</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandra%20Borkowska"> Aleksandra Borkowska</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20Torres"> Anna Torres</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Precocious puberty is the occurrence of secondary sexual characteristics in girls before the age of 8. The diverse etiology of premature puberty is crucial to determine whether it is true precocious puberty, depending on the activation of the hypothalamic-pituitary-gonadal axis, or pseudo-precocious, which is independent of the activation of this axis. Whatever the cause, premature action of the sex hormones leads to the common symptoms of various forms of puberty. These include the development of sexual characteristics, acne, acceleration of growth rate and acceleration of skeletal maturation. Due to the possible genetic basis of the disorders, an interdisciplinary search for the cause is needed. Case report: The case report concerns a patient of a pediatric gynecology clinic who, at the age of two years, developed advanced thelarhe (M3) and started recurrent vaginal bleeding. In August 2019, gonadotropin suppression initially and after LHRH stimulation and high estradiol levels were reported at the Endocrinology Department. Imaging examinations showed a cyst in the right ovary projection. The bone age was six years. The entire clinical picture indicated pseudo- (peripheral) precocious in the course of ovarian autonomic cyst. In the follow-up ultrasound performed in September, the image of the cyst was stationary and normalization of estradiol levels and clinical symptoms was noted. In December 2019, cyst regression and normal gonadotropin and estradiol concentrations were found. In June 2020, white mucus tinged with blood on the underwear, without any other disturbing symptoms, was observed for several days. Two consecutive USG examinations carried out in the same month confirmed the change in the right ovary, the diameter of which was 25 mm with a very high level of estradiol. Germinal tumor markers were normal. On the Tanner scale, the patient scored M2P1. The labia and hymen had puberty features. The correct vaginal entrance was visible. Another active vaginal bleeding occurred in the first week of July 2020. The considered laparoscopic treatment was abandoned due to the lack of oncological indications. Treatment with Tamoxifen was recommended in July 2020. In the initiating period of treatment, no maturation progression, and even reduction of symptoms, no acceleration of growth and a marked reduction in the size of the cysts were noted. There was no bleeding. After the size of the cyst and hormonal activity increased again, the treatment was changed to Anastrozole, the effect of which led to a reduction in the size of the cyst. Conclusions: The entire clinical picture indicates alleged (peripheral) puberty. Premature puberty in girls, which is manifested as enlarged mammary glands with high levels of estrogens secreted by autonomic ovarian cysts and prepubertal levels of gonadotropins, may indicate McCune-Albright syndrome. Vaginal bleeding may also occur in this syndrome. Cancellation of surgical treatment of the cyst made it impossible to perform a molecular test that would allow to confirm the diagnosis. Taking into account the fact that cysts are often one of the first symptoms of McCune-Albrigt syndrome, it is important to remember about multidisciplinary care for the patient and careful search for skin and bone changes or other hormonal disorders. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=McCune%20Albrigth%27s%20syndrome" title="McCune Albrigth's syndrome">McCune Albrigth's syndrome</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cyst" title=" ovarian cyst"> ovarian cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=pediatric%20gynaecology" title=" pediatric gynaecology"> pediatric gynaecology</a>, <a href="https://publications.waset.org/abstracts/search?q=precocious%20puberty" title=" precocious puberty"> precocious puberty</a> </p> <a href="https://publications.waset.org/abstracts/140652/precocious-puberty-due-to-an-autonomous-ovarian-cyst-in-a-3-year-old-girl-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140652.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">190</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">195</span> WT1 Expression in Ovarian Malignant Surface Epithelial Tumors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahmoodreza%20Tahamtan">Mahmoodreza Tahamtan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Malignant surface epithelial ovarian tumors(SEOT) account for approximately 90% of primary ovarian cancer. We evaluate the immunohistochemical expression of WT1 protein among different histologic subtypes of SEOT. Immunohistochemistry for WT1 was done on 35 serous cystadenocarcinomas, 9 borderline serous tumors. A tumor was considered negative if < 1% of tumor cells were stained.Positive reactions were graded as follows:1+,1%-24%; 2+,25%-49%; 3+,50%-74%; 4+,75%-100%. Of the 35 cases of ovarian serous cystadenocarcinoma 30(85.7%)were diffusely positive(3+,4+),4 showed reactivity of < 50% of the tumor cells(1+,2+) and one were negative. All 9 borderline serous tumors showed immunoreactivity with WT1. WT1 is a good marker to distinguish primary ovarian serous carcinomas from other surface epithelial tumors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=WT1" title="WT1">WT1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovary" title=" ovary"> ovary</a>, <a href="https://publications.waset.org/abstracts/search?q=malignant" title=" malignant"> malignant</a>, <a href="https://publications.waset.org/abstracts/search?q=epithelial%20tumors" title=" epithelial tumors"> epithelial tumors</a> </p> <a href="https://publications.waset.org/abstracts/160272/wt1-expression-in-ovarian-malignant-surface-epithelial-tumors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/160272.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">102</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">194</span> Prostatic Cyst in Suprapubic Ultrasound Examination</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Angelis%20P.%20Barlampas">Angelis P. Barlampas</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghita%20Bianca-Andreea"> Ghita Bianca-Andreea</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A case of a prostatic midline cyst is presented, which was found during a routine general ultrasound examination in an otherwise healthy young man. The incidence of prostatic cysts discovered in suprapubic ultrasound examination has constantly been rising over the previous decades. Despite the fact that the majority of them are benign, a significant amount is related to symptoms, such as pain, dysuria, infertility, and even cancer. The wide use of ultrasound examination and the increasing availability of high-resolution ultrasound systems have rendered new diagnostic challenges. Once upon a time a suprapubic ultrasound was only useful for measuring only the size and the dimensions of the prostatic gland. It did not have the ability to analyze and resolve structures such as cystic or solid nodules. The current machine equipment has managed to depict the imaging characteristics of lesions with high acuity that compares of an intrarectal ultrasound. But the last one is a specialized examination, which demands expertise and good knowledge. Maybe the time has come for the general radiologist and, especially the one who uses suprapubic ultrasound, to pay more attention to the examination of the prostate gland and to take advantage of the superb abilities and the high resolution of the new ultrasound systems. That is exactly, what this case is emphasizing. The incidental discovery of prostatic cysts, and the relatively little available literature about managing them turns them into an interesting theme for exploring and studying. The prostatic cysts are further divided into midline and paramidline cysts, with the first being usually utricle cysts. A more precise categorization is as follows: A midline cystic lesion usually regards a Mullerian duct cyst, a prostatic utricle cyst, an ejaculatory duct cyst, a prostatic cystadenoma, a ductus deferens cyst, and a TURP. On the other hand, a lateral cystic lesion usually refers to a cystic degeneration of benign prostatic hyperplasia, a prostatic retention cyst, a seminal vesicle cyst, diverticular prostatitis, a prostatic abscess, cavitatory prostatitis from chronic prostatitis, a parasitic prostatic cyst, a cystic prostatic carcinoma, e.t.c. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=prostatic%20cyst" title="prostatic cyst">prostatic cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=radiology" title=" radiology"> radiology</a>, <a href="https://publications.waset.org/abstracts/search?q=benign%20prostatic%20lesions" title=" benign prostatic lesions"> benign prostatic lesions</a>, <a href="https://publications.waset.org/abstracts/search?q=prostatic%20cancer" title=" prostatic cancer"> prostatic cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=suprapubic%20prostatic%20ultrasound" title=" suprapubic prostatic ultrasound"> suprapubic prostatic ultrasound</a> </p> <a href="https://publications.waset.org/abstracts/183418/prostatic-cyst-in-suprapubic-ultrasound-examination" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/183418.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">58</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">193</span> Rathke’s Cleft Cyst Presenting as Unilateral Visual Field Defect</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ritesh%20Verma">Ritesh Verma</a>, <a href="https://publications.waset.org/abstracts/search?q=Manisha%20Rathi"> Manisha Rathi</a>, <a href="https://publications.waset.org/abstracts/search?q=Chand%20Singh%20Dhull"> Chand Singh Dhull</a>, <a href="https://publications.waset.org/abstracts/search?q=Sumit%20Sachdeva"> Sumit Sachdeva</a>, <a href="https://publications.waset.org/abstracts/search?q=Jitender%20Phogat"> Jitender Phogat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A Rathke's cleft cyst is a benign growth found on the pituitary gland in the brain, specifically a fluid-filled cyst in the posterior portion of the anterior pituitary gland. It occurs when the Rathke's pouch does not develop properly and ranges in size from 2 to 40mm in diameter. A 38-year-old male presented to the outpatient department with loss of vision in the inferior quadrant of the left eye since 15 days. Visual acuity was 6/6 in the right eye and 6/9 in the left eye. Visual field analysis by HFA-24-2 revealed an inferior field defect extending to the supero-temporal quadrant in the left eye. MRI brain and orbit was advised to the patient and it revealed a well defined cystic pituitary adenoma indenting left optic nerve near optic chiasm consistent with the diagnosis of Rathke’s cleft cyst (RCC). The patient was referred to neurosurgery department for further management. Symptoms vary greatly between individuals having RCCs. RCCs can be non-functioning, functioning, or both. Besides headaches, neurocognitive deficits are almost always present but have a high rate of immediate reversal if the cyst is properly treated or drained. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pituitary%20tumors" title="pituitary tumors">pituitary tumors</a>, <a href="https://publications.waset.org/abstracts/search?q=rathke%E2%80%99s%20cleft%20cyst" title=" rathke’s cleft cyst"> rathke’s cleft cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=visual%20field%20defects" title=" visual field defects"> visual field defects</a>, <a href="https://publications.waset.org/abstracts/search?q=vision%20loss" title=" vision loss"> vision loss</a> </p> <a href="https://publications.waset.org/abstracts/84547/rathkes-cleft-cyst-presenting-as-unilateral-visual-field-defect" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84547.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">205</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">192</span> Role of Human Epididymis Protein 4 as a Biomarker in the Diagnosis of Ovarian Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amar%20Ranjan">Amar Ranjan</a>, <a href="https://publications.waset.org/abstracts/search?q=Julieana%20Durai"> Julieana Durai</a>, <a href="https://publications.waset.org/abstracts/search?q=Pranay%20Tanwar"> Pranay Tanwar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background &Introduction: Ovarian cancer is one of the most common malignant tumor in the female. 70% of the cases of ovarian cancer are diagnosed at an advanced stage. The five-year survival rate associated with ovarian cancer is less than 30%. The early diagnosis of ovarian cancer becomes a key factor in improving the survival rate of patients. Presently, CAl25 (carbohydrate antigen125) is used for the diagnosis and therapeutic monitoring of ovarian cancer, but its sensitivity and specificity is not ideal. The introduction of HE4, human epididymis protein 4 has attracted much attention. HE4 has a sensitivity and specificity of 72.9% and 95% for differentiating between benign and malignant adnexal masses, which is better than CA125 detection. Methods: Serum HE4 and CA -125 were estimated using the chemiluminescence method. Our cases were 40 epithelial ovarian cancer, 9 benign ovarian tumor, 29 benign gynaecological diseases and 13 healthy individuals. This group include healthy woman those who have undergoing family planning and menopause-related medical consultations and they are negative for ovarian mass. Optimal cut off values for HE4 and CA125 were 55.89pmol/L and 40.25U/L respectively (determined by statistical analysis). Results: The level of HE4 was raised in all ovarian cancer patients (n=40) whereas CA125 levels were normal in 6/40 ovarian cancer patients, which were the cases of OC confirmed by histopathology. There is a significant decrease in the level of HE4 with comparison to CA125 in benign ovarian tumor cases. Both the levels of HE4 and CA125 were raised in the nonovarian cancer group, which includes cancer of endometrium and cervix. In the healthy group, HE4 was normal in all patients except in one case of the rudimentary horn, and the reason for this raised HE4 level is due to the incomplete development of uterus whereas CA125 was raised in 3 cases. Conclusions: Findings showed that the serum level of HE4 is an important indicator in the diagnosis of ovarian cancer, and it also distinguishes between benign and malignant pelvic masses. However, a combination of HE4 and CA125 panel will be extremely valuable in improving the diagnostic efficiency of ovarian cancer. These findings of our study need to be validated in the larger cohort of patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20epididymis%20protein%204" title="human epididymis protein 4">human epididymis protein 4</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=benign%20lesions" title=" benign lesions"> benign lesions</a> </p> <a href="https://publications.waset.org/abstracts/108113/role-of-human-epididymis-protein-4-as-a-biomarker-in-the-diagnosis-of-ovarian-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/108113.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">131</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">191</span> Utility of CK7, CK20 and CDX-2 as a Potential Panel in Differentiating Primary Ovarian Surface Epithelial Tumors from Metastatic Adenocarcinoma to the Ovary</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghada%20Esheba">Ghada Esheba</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghadeer%20Aldoobi"> Ghadeer Aldoobi</a>, <a href="https://publications.waset.org/abstracts/search?q=Salwa%20Almalk"> Salwa Almalk</a>, <a href="https://publications.waset.org/abstracts/search?q=Abrar%20Alshareef"> Abrar Alshareef</a>, <a href="https://publications.waset.org/abstracts/search?q=Eman%20Al-khairi"> Eman Al-khairi</a>, <a href="https://publications.waset.org/abstracts/search?q=Eman%20Yaseen"> Eman Yaseen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: In Saudi Arabia, ovarian cancer ranked seventh among female population and is the most common female genital tract malignancy after endometrial cancer. A slight increase in the incidence of ovarian cancer was observed from 2001–2008. Makkah, Riyadh, and the eastern region of Saudi Arabia had the highest incidence rate ratio for the number of ovarian cancer cases (1). Differentiating metastatic adenocarcinomas from primary ovarian carcinomas, especially those of endometrioid and mucinous type is clinically signiﬁcant and a challenge for clinicians and pathologists, yet the distinction has important therapeutic and prognostic implications. Aim: To clarify the most important histopathological criteria to differentiate between primary ovarian surface epithelial tumors especially mucinous and endometrioid subtypes, and metastatic adenocarcinoma and to evaluate the value of a panel of antibodies consisting of CK7, CK20, and CDX-2 in the distinction between primary ovarian surface epithelial tumors and metastatic adenocarcinoma. Material and methods: This study was carried out on 26 cases of primary ovarian surface epithelial neoplasms and 14 cases of metastatic ovarian adenocarcinoma. All cases were studied immunohistochemically using CK7, CK20, and CDX-2. Results: All cases of primary ovarian adenocarcinoma were positive for CK7. 25% and 58% of mucinous borderline mucinous tumor and mucinous carcinoma respectively were positive for CK20. Only 42% of mucinous carcinoma were positive for CDX-2. All cases of endometrioid carcinomas were negative for both CK20 and CDX-2. All cases of metastatic adenocarcinoma from the colon were negative for CK7 and positive for CK20 and CDX-2. Conclusions: CK7 is an important positive marker for primary ovarian tumors, while CK20 and CDX-2 are useful markers for colorectal carcinoma metastatic to the ovary. Caution should be taken as primary ovarian mucinous tumors may stain positive for CK20, CDX-2, or both, however, they usually exhibit a focal pattern of reactivity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adenoma" title="adenoma">adenoma</a>, <a href="https://publications.waset.org/abstracts/search?q=endometrioid" title=" endometrioid"> endometrioid</a>, <a href="https://publications.waset.org/abstracts/search?q=malignancy" title=" malignancy"> malignancy</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian" title=" ovarian"> ovarian</a> </p> <a href="https://publications.waset.org/abstracts/43930/utility-of-ck7-ck20-and-cdx-2-as-a-potential-panel-in-differentiating-primary-ovarian-surface-epithelial-tumors-from-metastatic-adenocarcinoma-to-the-ovary" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43930.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">232</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">190</span> Congenital Sublingual Dermoid Cyst with Cutaneous Fistula</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rafael%20Ricieri">Rafael Ricieri</a>, <a href="https://publications.waset.org/abstracts/search?q=Rogerio%20Barros"> Rogerio Barros</a>, <a href="https://publications.waset.org/abstracts/search?q=Francisco%20Clovis"> Francisco Clovis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective– The Objective of this is study is to report a rare case of dermoid cyst, with a sublingual location and cutaneous fistula in a 4 year-old child.Methods: This study is a case report. The main study instrument was the medical record and the radiological and intraoperative image bank. Results: Infants with congenital cervical lesions eventually need tomography for diagnostic elucidation, and health services should be structured to perform sedation and thin tomographic sections in order to reduce morbidity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=congenital" title="congenital">congenital</a>, <a href="https://publications.waset.org/abstracts/search?q=sublingual%20dermoid%20cyst" title=" sublingual dermoid cyst"> sublingual dermoid cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=fistula" title=" fistula"> fistula</a>, <a href="https://publications.waset.org/abstracts/search?q=pediatric%20surgery" title=" pediatric surgery"> pediatric surgery</a>, <a href="https://publications.waset.org/abstracts/search?q=head%20and%20kneck%20surgery" title=" head and kneck surgery"> head and kneck surgery</a> </p> <a href="https://publications.waset.org/abstracts/156843/congenital-sublingual-dermoid-cyst-with-cutaneous-fistula" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156843.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">91</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">189</span> Endometriosis-Associated Ovarian Cancer: Clinical and Pathological Pattern</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Ramalho">I. Ramalho</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Campos"> S. Campos</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Dias"> M. Dias</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Endometriosis may play a role in the pathogenesis of ovarian cancer (OC), however, the risk and prognosis have not been well established. The association between these two pathologies could have an important impact on prevention and early diagnosis of OC. Objective: To analyze the prevalence of endometriosis associated ovarian cancer and related clinical, epidemiological and histopathological issues. Design: We conducted a retrospective case series analysis of patients diagnosed with endometriosis and ovarian cancer in the Gynecology Department of Coimbra University Hospital Center since 2006 to 2015. Methods: We collected data from women diagnosed with ovarian cancer, with anatomopathology records reporting findings of endometriosis in ovarian cancer patients. Patients were retrieved from the pathological records and appropriate medical records were retrospectively reviewed. Statistical analysis was performed using SPSS 22.0. Results: Histological evidence of endometriosis was found in 17 out of 261 patients diagnosed with ovarian cancer (OC) (6.51%). The most usual symptoms were pelvic pain, abdominal distension, asthenia, ascites, weight loss and nausea. Mean age at diagnosis was 61.2 ± 15.1, 41-86 years old, 33.3% were pre-menopausal patients and cancer stage distribution was predominantly stage I (31.3%) and stage III (56.3%). OC occurred unilaterally in 14 patients and 2 patients were diagnosed with a synchronous ovarian and endometrial cancer. Regarding histological type, 10 OC were classified as clear cell carcinoma (CCC), 4 endometrioid carcinomas (EC) and 3 mixed type (clear cell and endometrioid). Four ovarian carcinomas presumably arose from endometriomas: 3 CCC and 1 EC. Conclusions: In accordance with previous studies, clear cell was the most common pathological type in endometriotic patients, followed by endometrioid carcinomas, and two rare synchronous ovarian and endometrial carcinomas were registered. Although endometriosis association to OC is uncommon, endometriosis should be managed with special care in order to early diagnosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometriosis" title="endometriosis">endometriosis</a>, <a href="https://publications.waset.org/abstracts/search?q=histology" title=" histology"> histology</a>, <a href="https://publications.waset.org/abstracts/search?q=observational%20study" title=" observational study"> observational study</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a> </p> <a href="https://publications.waset.org/abstracts/71642/endometriosis-associated-ovarian-cancer-clinical-and-pathological-pattern" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71642.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">229</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">188</span> FDX1, a Cuproptosis-Related Gene, Identified as a Potential Target for Human Ovarian Aging</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Li-Te%20Lin">Li-Te Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Chia-Jung%20Li"> Chia-Jung Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Kuan-Hao%20Tsui"> Kuan-Hao Tsui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cuproptosis, a newly identified cell death mechanism, has attracted attention for its association with various diseases. However, the genetic interplay between cuproptosis and ovarian aging remains largely unexplored. This study aims to address this gap by analyzing datasets related to ovarian aging and cuproptosis. Spatial transcriptome analyses were conducted in the ovaries of both young and aged female mice to elucidate the role of FDX1. Comprehensive bioinformatics analyses, facilitated by R software, identified FDX1 as a potential cuproptosis-related gene with implications for ovarian aging. Clinical infertility biopsies were examined to validate these findings, showing consistent results in elderly infertile patients. Furthermore, pharmacogenomic analyses of ovarian cell lines explored the intricate association between FDX1 expression levels and sensitivity to specific small molecule drugs. Spatial transcriptome analyses revealed a significant reduction in FDX1 expression in aging ovaries, supported by consistent findings in biopsies from elderly infertile patients. Pharmacogenomic investigations indicated that modulating FDX1 could influence drug responses in ovarian-related therapies. This study pioneers the identification of FDX1 as a cuproptosis-related gene linked to ovarian aging. These findings not only contribute to understanding the mechanisms of ovarian aging but also position FDX1 as a potential diagnostic biomarker and therapeutic target. Further research may establish FDX1's pivotal role in advancing precision medicine and therapies for ovarian-related conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cuproptosis" title="cuproptosis">cuproptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=FDX1" title=" FDX1"> FDX1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20aging" title=" ovarian aging"> ovarian aging</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarker" title=" biomarker"> biomarker</a> </p> <a href="https://publications.waset.org/abstracts/186481/fdx1-a-cuproptosis-related-gene-identified-as-a-potential-target-for-human-ovarian-aging" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186481.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">39</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">187</span> Isolated Hydatidosis of Spleen: A Rare Entity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anshul%20Raja">Anshul Raja</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cystic lesions of the spleen are rare and splenic hydatid cysts account for only 0.5% to 8% of all hydatidosis. Authors hereby report a case where a 50-year-old female presented to our hospital with the complains of heaviness and pain over left upper abdomen over the past 8-10 years. On radiological examination, ultrasonography revealed findings consistent with isolated splenic hydatid cyst and was later on confirmed on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). No other organ or system involvement was seen. The patient underwent splenectomy and hydatid cyst was confirmed on histopathology. Owing to its rarity, it offers a diagnostic challenge to physicians but can reliably be diagnosed with great confidence employing various imaging modalities like CT and MRI. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gastrointestinal%20radiology" title="gastrointestinal radiology">gastrointestinal radiology</a>, <a href="https://publications.waset.org/abstracts/search?q=abdominal%20imaging" title=" abdominal imaging"> abdominal imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=hydatid%20cyst" title=" hydatid cyst"> hydatid cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20and%20health%20sciences" title=" medical and health sciences"> medical and health sciences</a> </p> <a href="https://publications.waset.org/abstracts/18260/isolated-hydatidosis-of-spleen-a-rare-entity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">405</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">186</span> Effect of Unilateral Unoperated Ovarian Endometrioma on Responsiveness to Hyperstimulation </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdelmaguid%20Ramzy">Abdelmaguid Ramzy</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Bahaa"> Mohamed Bahaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The effects of ovarian endometrioma on fertility outcomes with IVF have been always related to poor outcomes. Objective: To evaluate the effect of unilateral unoperated ovarian endometrioma < 2cm on the number of developing follicles and compare them with the contralateral ovary as a control. Design: Retrospective case control study. Setting: KasrEl-Aini IVF center. Patient(s): We studied 32 women with unilateral endometrioma who underwent their first IVF cycle. Methods: 32 Patients aged between 20-35 years selected for IVF who were diagnosed with one unilateral endometrioma (diameter <2 cm) and who did not undergo previous ovarian surgery were retrospectively identified. The number of follicles > 17 mm during folliculometry on the day of HCG trigger in the ovary that contained endometrioma were compared with those from the contralateral ovary. They were all hyperstimulated using long protocol with (225-300 IU) gonadotrophins. Primary outcome: The number of follicles > 17 mm during folliculometry on the day of HCG trigger. Result(s): The mean ± SD age, Day 3 serum FSH and LH were 27± 3.7 years, 5.8 ± 1.6 IU/ml and 4.5 ± 1.7 IU/ml respectively. There was no significant difference in the number of follicles > 17 mm on the day of HCG trigger in the ovary that contained endometrioma (4.4 ±2.5) and in the opposite ovary (4.5 ± 2.8) (P= 0.48). Conclusion: The presence of ovarian endometrioma in a controlled ovarian hyperstimulation cycle for IVF treatment is not associated with a reduced number of follicles > 17 mm during folliculometry on the day of HCG trigger. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometrioma" title="endometrioma">endometrioma</a>, <a href="https://publications.waset.org/abstracts/search?q=folliculometry" title=" folliculometry"> folliculometry</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperstimulation" title=" hyperstimulation"> hyperstimulation</a>, <a href="https://publications.waset.org/abstracts/search?q=fertility" title=" fertility"> fertility</a> </p> <a href="https://publications.waset.org/abstracts/8259/effect-of-unilateral-unoperated-ovarian-endometrioma-on-responsiveness-to-hyperstimulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8259.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">209</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">185</span> Expression of Hypoxia-Inducible Transmembrane Carbonic Anhydrases IX, Ca XII and Glut 1 in Ovarian Cancer </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Sunitha">M. Sunitha</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Nithyavani"> B. Nithyavani</a>, <a href="https://publications.waset.org/abstracts/search?q=Mathew%20Yohannan"> Mathew Yohannan</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Thiruvieni%20Balajji"> S. Thiruvieni Balajji</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20A.%20Rathi"> M. A. Rathi</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Arul%20Raj"> C. Arul Raj</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Ragavendran"> P. Ragavendran</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20K.%20Gopalkrishnan"> V. K. Gopalkrishnan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Establishment of an early and reliable biomarker for ovarian carcinogenesis whose expression can be monitored through noninvasive techniques will enable early diagnosis of cancer. Carbonic anhydrases (CA) isozymes IX and XII have been suggested to play a role in oncogenic processes. In von Hippel-Lindau (VHL)-defective tumors, the cell surface transmembrane carbonic anhydrase (CA) CA XI and CA XII genes are overexpressed because of the absence of pVHL. These enzymes are involved in causing a hypoxia condition, thereby providing an environment for metastasis. Aberrant expression of the facilitative glucose transporter GLUT I is found in a wide spectrum of epithelial malignancies. Studying the mRNA expression of CA IX, CA XII and Glut I isozymes in ovarian cancer cell lines (OAW-42 and PA-1) revealed the expression of these hypoxia genes. Immunohistochemical staining of carbonic anhydrases was also performed in 40 ovarian cancer tissues. CA IX and CA XII were expressed at 540 bp and 520 bp in OAW42, PA1 in ovarian cancer cell lines. GLUT-1 was expressed at 325bp in OAW 42, PA1 genes in ovarian cancer cell lines. Immunohistochemistry revealed high to moderate levels of expression of these enzymes. The immuostaining was seen predominantly on the cell surface membrane. The study concluded that these genes CA IX, CA XII and Glut I are expressed under hypoxic condition in tumor cells. From the present results expression of CA IX, XII and Glut I may represent potential targets in ovarian cancer therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title="ovarian cancer">ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=carbonic%20anhydrase%20IX" title=" carbonic anhydrase IX"> carbonic anhydrase IX</a>, <a href="https://publications.waset.org/abstracts/search?q=XII" title=" XII"> XII</a>, <a href="https://publications.waset.org/abstracts/search?q=Glut%20I" title=" Glut I"> Glut I</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20markers" title=" tumor markers "> tumor markers </a> </p> <a href="https://publications.waset.org/abstracts/9998/expression-of-hypoxia-inducible-transmembrane-carbonic-anhydrases-ix-ca-xii-and-glut-1-in-ovarian-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9998.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">369</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">184</span> Rejuvenation of Premature Ovarian Failure with Stem Cells/IVA Technique</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elham%20Vojoudi">Elham Vojoudi</a>, <a href="https://publications.waset.org/abstracts/search?q=Marzieh%20Mehrafza"> Marzieh Mehrafza</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmad%20Hosseini"> Ahmad Hosseini</a>, <a href="https://publications.waset.org/abstracts/search?q=Azadeh%20Raofi"> Azadeh Raofi</a>, <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Najafi"> Maryam Najafi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Premature ovarian failure (POF) has become one of the main causes of infertility in women of childbearing age and the incidence of this disorder is increasing year by year. In these patients, poor ovarian response (POR) to gonadotropins reflects a diminished ovarian reserve (DOR) that gives place to few follicles despite aggressive stimulation. Up to now, egg donation is the only way to resolve infertility problems in POF patients. Therefore, some novel aspects such as activating (Akt signaling pathway) and inhibiting (Hippo-signaling) elements have been identified as IVA procedure that promotes primordial follicle activation. In this study, we used the newly developed technique (combination of in vitro activation of dormant follicles (IVA) and stem cell therapy) to promote ovarian follicle growth much more efficiently than the natural, in vivo process for women with POF. Transplantation of Warton Jelly-MSCs to the ovaries of POF patients rescued overall ovarian function. Participants (10 patients) were followed up monthly for a period of six months by hormonal (AMH, FSH, LH and E2), clinical (resuming menstruation), and US (folliculometry) outcomes after a laparoscopic operation. In summary, IVA/WJ-MSC transplantation may provide an effective treatment for POF. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=POF" title="POF">POF</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20activation" title=" in vitro activation"> in vitro activation</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cell%20therapy" title=" stem cell therapy"> stem cell therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=infertility" title=" infertility"> infertility</a> </p> <a href="https://publications.waset.org/abstracts/149531/rejuvenation-of-premature-ovarian-failure-with-stem-cellsiva-technique" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149531.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">130</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">183</span> Rethinking the Value of Pancreatic Cyst CEA Levels from Endoscopic Ultrasound Fine-Needle Aspiration (EUS-FNA): A Longitudinal Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Giselle%20Tran">Giselle Tran</a>, <a href="https://publications.waset.org/abstracts/search?q=Ralitza%20Parina"> Ralitza Parina</a>, <a href="https://publications.waset.org/abstracts/search?q=Phuong%20T.%20Nguyen"> Phuong T. Nguyen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background/Aims: Pancreatic cysts (PC) have recently become an increasingly common entity, often diagnosed as incidental findings on cross-sectional imaging. Clinically, management of the lesions is difficult because of uncertainties in their potential for malignant degeneration. Prior series have reported that carcinoembryonic antigen (CEA), a biomarker collected from cyst fluid aspiration, has a high diagnostic accuracy for discriminating between mucinous and non-mucinous lesions, at the patient’s initial presentation. To the author’s best knowledge, no prior studies have reported PC CEA levels obtained from endoscopic ultrasound fine-needle aspiration (EUS-FNA) over years of serial EUS surveillance imaging. Methods: We report a consecutive retrospective series of 624 patients who underwent EUS evaluation for a PC between 11/20/2009 and 11/13/2018. Of these patients, 401 patients had CEA values obtained at the point of entry. Of these, 157 patients had two or more CEA values obtained over the course of their EUS surveillance. Of the 157 patients (96 F, 61 M; mean age 68 [range, 62-76]), the mean interval of EUS follow-up was 29.7 months [3.5-128]. The mean number of EUS procedures was 3 [2-7]. To assess CEA value fluctuations, we defined an appreciable increase in CEA as "spikes" – two-times increase in CEA on a subsequent EUS-FNA of the same cyst, with the second CEA value being greater than 1000 ng/mL. Using this definition, cysts with a spike in CEA were compared to those without a spike in a bivariate analysis to determine if a CEA spike is associated with poorer outcomes and the presence of high-risk features. Results: Of the 157 patients analyzed, 29 had a spike in CEA. Of these 29 patients, 5 had a cyst with size increase >0.5cm (p=0.93); 2 had a large cyst, >3cm (p=0.77); 1 had a cyst that developed a new solid component (p=0.03); 7 had a cyst with a solid component at any time during surveillance (p=0.08); 21 had a complex cyst (p=0.34); 4 had a cyst categorized as "Statistically Higher Risk" based on molecular analysis (p=0.11); and 0 underwent surgical resection (p=0.28). Conclusion: With serial EUS imaging in the surveillance of PC, an increase in CEA level defined as a spike did not predict poorer outcomes. Most notably, a spike in CEA did not correlate with the number of patients sent to surgery or patients with an appreciable increase in cyst size. A spike in CEA did not correlate with the development of a solid nodule within the PC nor progression on molecular analysis. Future studies should focus on the selected use of CEA analysis when patients undergo EUS surveillance evaluation for PCs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carcinoembryonic%20antigen%20%28CEA%29" title="carcinoembryonic antigen (CEA)">carcinoembryonic antigen (CEA)</a>, <a href="https://publications.waset.org/abstracts/search?q=endoscopic%20ultrasound%20%28EUS%29" title=" endoscopic ultrasound (EUS)"> endoscopic ultrasound (EUS)</a>, <a href="https://publications.waset.org/abstracts/search?q=fine-needle%20aspiration%20%28FNA%29" title=" fine-needle aspiration (FNA)"> fine-needle aspiration (FNA)</a>, <a href="https://publications.waset.org/abstracts/search?q=pancreatic%20cyst" title=" pancreatic cyst"> pancreatic cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=spike" title=" spike"> spike</a> </p> <a href="https://publications.waset.org/abstracts/148012/rethinking-the-value-of-pancreatic-cyst-cea-levels-from-endoscopic-ultrasound-fine-needle-aspiration-eus-fna-a-longitudinal-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/148012.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">182</span> Effects of New Anthraquinone Derivatives on Resistance Ovarian Cancer Cells and The Mechanism Investigation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hui-Hsin%20Huang">Hui-Hsin Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Sheng-Tung%20Huang"> Sheng-Tung Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi-Ming%20Lee"> Chi-Ming Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Chiao-Han%20Yen"> Chiao-Han Yen</a>, <a href="https://publications.waset.org/abstracts/search?q=Chun-Mao%20Lin"> Chun-Mao Lin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> At initiation stage, there are no symptoms at initiation stage; however, at late stage, patients suffer symptoms as soon as ovarian cancer metastasis. Moreover, ovarian cancer cells are resistant to some anti-ovarian cancer drugs in clinical. Thus, it is very important to find an effective treatment for resistant ovarian cancer. Anthraquinone derivatives are able to induce DNA damage and lead to cell apoptosis, so several derivatives have been used for clinical application. Therefore, to explore more effective anti-ovarian cancer drugs, this study investigates the mechanism of three new anthraquinone compounds bearing different functional groups to camptothecin-resistance ovarian cell line A2780R2000. Cell viability was determined by MTT assay after treating A2780R2000 with the three new anthraquinone compounds. The results indicated that IC50 values are 33.44μM (Compound I), 25.77μM (Compound II) and 24.59μM (Compound III). Next, through cell cycle analysis, the results demonstrated that three new anthraquinone compounds not only induced A2780R2000 cell cycle arrest at early stage but also apoptosis at late stage. Besides, through apoptosis assay, the results indicated new anthraquinone compound induced apoptosis at late stage. Furthermore, the results of western blot show that the three new anthraquinone compounds lead to A2780R2000 apoptosis through intrinsic pathway. Theses results suggested that three new anthraquinone compounds may be potential new drugs for clinical cancer treatment in the future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anthraquinone" title="anthraquinone">anthraquinone</a>, <a href="https://publications.waset.org/abstracts/search?q=camptothecin" title=" camptothecin"> camptothecin</a>, <a href="https://publications.waset.org/abstracts/search?q=resistance" title=" resistance"> resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a> </p> <a href="https://publications.waset.org/abstracts/44883/effects-of-new-anthraquinone-derivatives-on-resistance-ovarian-cancer-cells-and-the-mechanism-investigation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44883.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">394</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">181</span> Risk Factors and Biomarkers for the Recurrence of Ovarian Endometrioma: About the Immunoreactivity of Progesterone Receptor Isoform B and Nuclear Factor Kappa B.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ae%20Ra%20Han">Ae Ra Han</a>, <a href="https://publications.waset.org/abstracts/search?q=Taek%20Hoo%20Lee"> Taek Hoo Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Sun%20Zoo%20Kim"> Sun Zoo Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Hwa%20Young%20%20Lee"> Hwa Young Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Ovarian endometrioma is one of the important causes of poor ovarian reserve and up to half of them have recurred. However, the treatment for recurrence prevention has limited efficiency and repeated surgical management makes worsen the ovarian reserve. To find better management for recurrence prevention, we investigated risk factors and biomarkers for the recurrence of ovarian endometrioma. Methods: The medical records of women with the history of surgical dissection for ovarian endometrioma were collected. After exclusion of the cases with concurrent hysterectomy, been menopaused during follow-up, incomplete medical record, and loss of follow-up, a total of 134 women were enrolled. Immunohistochemical staining for progesterone receptor isoform B (PR-B) and nuclear factor kappa B (NFκB) was done with the fixed tissue blocks of their endometriomas which were collected at the time of surgery. Results: Severity of dysmenorrhea and co-existence of adenomyosis had significant correlation with recurrence of endometrioma. Increased PR-B (P = .041) and decreased NFκB (P = .036) immunoreactivity were found in recurrent group. Serum CA-125 level at the time of recurrence was higher than the highest level of CA-125 during follow-up in unrecurred group (55.6 vs. 21.3 U/mL, P = .014). Conclusion: We found that the severity of dysmenorrhea and coexistence of adenomyosis are risk factors for recurrence of ovarian endometrioma, and serial follow-up of CA-125 is effective to detect and prevent the recurrence. However, to determine the possibility of immunoreactivity of PR-B and NFκB as biomarkers for ovarian endometrioma, further studies of various races and large numbers with prospective design are needed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometriosis" title="endometriosis">endometriosis</a>, <a href="https://publications.waset.org/abstracts/search?q=recurrence" title=" recurrence"> recurrence</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarker" title=" biomarker"> biomarker</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20factor" title=" risk factor"> risk factor</a> </p> <a href="https://publications.waset.org/abstracts/50727/risk-factors-and-biomarkers-for-the-recurrence-of-ovarian-endometrioma-about-the-immunoreactivity-of-progesterone-receptor-isoform-b-and-nuclear-factor-kappa-b" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50727.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">553</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">180</span> Ovarian Stimulation and Oocyte Cryopreservation for Fertility Preservation in Adolescent Females at the Royal Children’s Hospital: A Case Series</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kira%20Merigan">Kira Merigan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> BACKGROUND- Fertility preservation (FP) measures are increasingly recognised as an important consideration for children and adolescents planned to undergo potentially damaging gonadotoxic therapy. Worldwide, there are very few documented cases of FP in young females by way of ovarian stimulation and oocyte cryopreservation.AIM – To report a case series of mature oocyte cryopreservation in 5post-pubertal adolescents aged 14-17 years old, with varied medical conditions requiring gonadotoxic treatment. SETTING-These cases took place via a multidisciplinary team approach at The Royal Children’s Hospital, a large tertiary centre in Melbourne, Australia. INTERVENTION– Ovarian stimulation and oocyte collection was performed as detailed in each case. RESULTS –Across the 5 patients, 3-28 oocytes were retrieved. We report pre-treatment workup, complications, and delays to treatment. CONCLUSION- Oocyte cryopreservation may be a safe alternative to ovarian tissue cryopreservation (OTC) in the adolescent population <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fertility%20preservation" title="fertility preservation">fertility preservation</a>, <a href="https://publications.waset.org/abstracts/search?q=adolescent" title=" adolescent"> adolescent</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20stimulation" title=" ovarian stimulation"> ovarian stimulation</a>, <a href="https://publications.waset.org/abstracts/search?q=oocyte%20cryopreservation" title=" oocyte cryopreservation"> oocyte cryopreservation</a> </p> <a href="https://publications.waset.org/abstracts/145436/ovarian-stimulation-and-oocyte-cryopreservation-for-fertility-preservation-in-adolescent-females-at-the-royal-childrens-hospital-a-case-series" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/145436.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">167</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">179</span> Comprehensive Multi-Omics Study Highlights Osteopontin/SPP1 in Ovarian Aging Control</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chia-Jung%20Li">Chia-Jung Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Li-Te%20Lin"> Li-Te Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Kuan-Hao%20Tsui"> Kuan-Hao Tsui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study identifies SPP1 as a potential gene associated with ovarian aging, revealing a significant decline in its expression in aged ovaries. SPP1, also known as osteopontin (OPN), is a multifunctional glycoprotein involved with regulatory proteins and pro-inflammatory immune chemokines. However, its genetic links to ovarian aging have not been extensively explored. Spatial transcriptomic analyses were conducted on ovaries from young and aged female mice, along with a sample from a 73-year-old individual. Additionally, single-cell RNA sequencing analysis was performed to identify associations between SPP1 and key genes. The study focused on crucial genes, including ITGAV, ITGB1, CD44, MMP3, and FN1, with a particular emphasis on the correlation between SPP1 and ITGB1. The findings indicate a significant decline in SPP1 expression in aged ovaries, which was consistent in the 73-year-old sample. Single-cell RNA sequencing unveiled associations between SPP1 and key genes, emphasizing a strong co-expression correlation between SPP1 and ITGB1. While the study provides valuable insights, further research is necessary to understand the broader implications and potential applications of SPP1 in ovarian aging. Translating these findings to clinical settings requires careful consideration. The identification of SPP1 as a gene implicated in ovarian aging opens new avenues for advancing precision medicine and refining treatment strategies for conditions related to ovarian aging. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=SPP1" title="SPP1">SPP1</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20aging" title=" ovarian aging"> ovarian aging</a>, <a href="https://publications.waset.org/abstracts/search?q=spatial%20transcriptomic" title=" spatial transcriptomic"> spatial transcriptomic</a>, <a href="https://publications.waset.org/abstracts/search?q=single-cell%20RNA%20sequencing" title=" single-cell RNA sequencing"> single-cell RNA sequencing</a> </p> <a href="https://publications.waset.org/abstracts/186479/comprehensive-multi-omics-study-highlights-osteopontinspp1-in-ovarian-aging-control" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186479.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">35</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">178</span> Stomach Perforation, due to Chronic External Pressure</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Angelis%20P.%20Barlampas">Angelis P. Barlampas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> PURPOSE: The purpose of this paper is to demonstrate the important role of taking an appropriate and detailed history, in order to reach the best possible diagnostic conclusion. MATERIAL: A patient presented to the emergency department due to the sudden onset of continuous abdominal pain, during the last hour and with the clinical symptoms of an acute abdomen. During the clinical examination, signs of peritoneal irritation and diffuse abdominal tenderness were found. The rest of the clinical and laboratory tests did not reveal anything important. From the reported medical history, nothing of note was found, except for the report of a large liver cyst, for which he was advised not to take any further action, except from regular ultrasound examination . METHOD: A computed tomography examination was performed after per os administration of gastrografin, which revealed a hyperdense ascitic effusion, similar in density to that of gastrografin within the intestinal tract. The presence of a large cyst of the left hepatic lobe was confirmed, contacting and pushing against the stomach. In the area of the contact between the liver cyst and the pylorus, there were extraluminal air bubbles and local opacity of the peritoneal fat, with a small hyperdense effusion. Result : The above, as well as the absence of a history of stomach ulcer or recent trauma, or other pathology, argue in favor of acute pyloric perforation, due to mural necrosis, in response to chronic external pressure from the pre-existing large liver cyst. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=perforation" title="perforation">perforation</a>, <a href="https://publications.waset.org/abstracts/search?q=stomach" title=" stomach"> stomach</a>, <a href="https://publications.waset.org/abstracts/search?q=large%20liver%20cyst" title=" large liver cyst"> large liver cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=CT%20abdomen" title=" CT abdomen"> CT abdomen</a>, <a href="https://publications.waset.org/abstracts/search?q=acute%20abdominal%20pain" title=" acute abdominal pain"> acute abdominal pain</a>, <a href="https://publications.waset.org/abstracts/search?q=intraperitoneal%20leakage" title=" intraperitoneal leakage"> intraperitoneal leakage</a>, <a href="https://publications.waset.org/abstracts/search?q=constrast%20leakage" title=" constrast leakage"> constrast leakage</a> </p> <a href="https://publications.waset.org/abstracts/170426/stomach-perforation-due-to-chronic-external-pressure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170426.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">96</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">177</span> Genetic Determinants of Ovarian Response to Gonadotropin Stimulation in Women Undergoing Assisted Reproductive Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20Tohlob">D. Tohlob</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Abo%20Hashem"> E. Abo Hashem</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Ghareeb"> N. Ghareeb</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Ghanem"> M. Ghanem</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Elfarahaty"> R. Elfarahaty</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20A.%20Roberts"> S. A. Roberts</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Pemberton"> P. Pemberton</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Mohiyiddeen"> L. Mohiyiddeen</a>, <a href="https://publications.waset.org/abstracts/search?q=W.%20G.%20Newman"> W. G. Newman </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gonadotropin stimulation is used in females undergoing assisted reproductive treatment for ovulation induction, but ovarian response is variable and unpredictable in these women. More effective protocols and individualization of treatment are needed to increase the success rate of IVF/ICSI cycles. We genotyped seven variants reported in previous studies to be associated with ovarian response (number of ova retrieved and total gonadotropin dose) in women undergoing IVF treatment including FSHR variants Asn 680 Ser (c.2039 A > G), Thr 307 Ala (c. 919 > A), -29 G > A, HRG c.610 C > T gene, BMP15 -9 C > G, AMH Ile 49 Ser (c.146 G > T), and AMHR -489A˃G in 118 Egyptian females attending Mansoura Integrated Fertility Center in Egypt, these females were undergoing their first cycle of controlled ovarian hyper stimulation for IVF/ICSI treatment. They were analyzed by TaqMan allelic discrimination assay in Manchester Center of Genomic Medicine. We found no evidence of any significant difference (p value < 0.05) in the number of eggs retrieved or the gonadotropin dose used between individuals in all genotypes except for HRG c.610 C > T gene polymorphism where regression analysis gives a p value of 0.04 with a fewer eggs number in TT genotyped females. These results indicate that these variants do not provide sufficient clinically relevant data to individualize the treatment protocols. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20ovarian%20hyperstimulation" title="controlled ovarian hyperstimulation">controlled ovarian hyperstimulation</a>, <a href="https://publications.waset.org/abstracts/search?q=gene%20variants" title=" gene variants"> gene variants</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20response" title=" ovarian response"> ovarian response</a>, <a href="https://publications.waset.org/abstracts/search?q=assisted%20reproduction" title=" assisted reproduction"> assisted reproduction</a> </p> <a href="https://publications.waset.org/abstracts/37258/genetic-determinants-of-ovarian-response-to-gonadotropin-stimulation-in-women-undergoing-assisted-reproductive-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37258.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">319</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">176</span> Coexisting Pathology of Unruptured Ectopic Pregnancy With Concurrent Ipsilateral Dermoid Cyst: A Rare Occurrence</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anne%20Nicole%20Fuentes">Anne Nicole Fuentes</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A 29 year old Gravida 1 Para 0 who presented at the hospital with a 5-week history of amenorrhea, abdominal pain and vaginal bleeding. Transvaginal ultrasound revealed 3 pathologic findings : Tuboovarian complex on the right adnexa, a complex mass indicative of an unruptured ectopic pregnancy and right ovarian new growth probably endometrioma. Pelvic laparotomy was done and histopathologic finding revealed tubal pregnancy, right and mature cystic teratoma of the right ovary. This case report demonstrates the importance of considering the coexistence of different gynecologic pathologies in the same patient and clinical importance of an accurate diagnostic evaluation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mature%20cystic%20teratoma" title="mature cystic teratoma">mature cystic teratoma</a>, <a href="https://publications.waset.org/abstracts/search?q=ectopic%20pregnancy" title=" ectopic pregnancy"> ectopic pregnancy</a>, <a href="https://publications.waset.org/abstracts/search?q=Tuboovarian%20abscess" title=" Tuboovarian abscess"> Tuboovarian abscess</a>, <a href="https://publications.waset.org/abstracts/search?q=bHCG" title=" bHCG"> bHCG</a> </p> <a href="https://publications.waset.org/abstracts/168096/coexisting-pathology-of-unruptured-ectopic-pregnancy-with-concurrent-ipsilateral-dermoid-cyst-a-rare-occurrence" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168096.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">144</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">175</span> Borderline Ovarian Tumor: Management of Recurrence After Conservative Surgical Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghorbeli%20Eya">Ghorbeli Eya</a>, <a href="https://publications.waset.org/abstracts/search?q=Naija%20Lamia"> Naija Lamia</a>, <a href="https://publications.waset.org/abstracts/search?q=Khessairi%20Nayssem"> Khessairi Nayssem</a>, <a href="https://publications.waset.org/abstracts/search?q=Saadallah%20Fatma"> Saadallah Fatma</a>, <a href="https://publications.waset.org/abstracts/search?q=Slimane%20Maher"> Slimane Maher</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarek%20Ben%20Dhiab"> Tarek Ben Dhiab</a> </p> <p class="card-text"><strong>Abstract:</strong></p> INTRODUCTION: Borderline ovarian tumors account for 15 to 20% of ovarian tumors. Prognostic factors of recurrence include the stage of the disease, presence of peritoneal implants, micropapillary pattern, microinvasion and intra-epithelial carcinoma. Fertility sparing constitutes a major therapeutic issue in young patients that leads to conservative surgical treatment in specific cases. METHODS: We conducted a retrospective descriptive study including patients treated at the Salah Azaiez Institute for Borderline Ovarian Tumor who underwent conservative surgical treatment from 2003 to 2018. RESULTS: Nine patients were included in our study. The median age was 33 years. Three patients were nulliparous. Given the age, conservative treatment was indicated in all these patients. Cystectomy without ovariectomy was indicated in 5 of the 9 women, which was within the margin of tumor resection on definitive anatomopathic examination in 3 of the 5 women. In contrast, given the impossibility of ovarian conservation, total annexectomy was carried out in 4 of all these women. All of the patients were followed regularly postoperatively; three had a carcinomatous transformation as an ovarian adenocarcinoma at an average interval of 18 months. Among these three patients, a single one presented intra-peritoneal metastases, requiring radical surgical treatment and adjuvant chemotherapy with 6 cures of Carbo-Taxol, with a good tolerance and a complete response. Moreover, one patient had a recurrence on the contralateral ovary as a Borderline mucinous ovarian tumor. For the remaining four women, after a median follow-up of 35 months, one patient fell spontaneously pregnant during follow-up, and three patients were in complete remission at 16 months. CONCLUSION: Borderline tumors of the ovary usually occur in young patients, which makes conservative treatment advisable if possible, but this always comes with a risk of recurrence and/or carcinomatous transformation, especially if the conservative surgical procedure was a cystectomy instead of a total annexectomy, and even more so if the resection margins were tumoral. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ovarian%20tumor" title="ovarian tumor">ovarian tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=conservative%20treatment" title=" conservative treatment"> conservative treatment</a>, <a href="https://publications.waset.org/abstracts/search?q=surgical%20management" title=" surgical management"> surgical management</a>, <a href="https://publications.waset.org/abstracts/search?q=borderline%20ovarian%20tumor" title=" borderline ovarian tumor"> borderline ovarian tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=recurrence%20management" title=" recurrence management"> recurrence management</a> </p> <a href="https://publications.waset.org/abstracts/190122/borderline-ovarian-tumor-management-of-recurrence-after-conservative-surgical-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/190122.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">28</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">174</span> Sexual Satifaction in Women with Polycystic Ovarian Syndrome</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nashi%20Khan">Nashi Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Amina%20Khalid"> Amina Khalid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: The purpose of this research was to find the psychiatric morbidity and level of sexual satisfaction among women with polycystic ovarian syndrome and their comparison with women with general medical conditions and to examine the correlation between psychiatric morbidity and sexual satisfaction among these women. Design: Cross sectional research design was used. Method: A total of 176 (M age = 30, SD = 5.83) women were recruited from both private and public sector hospitals in Pakistan. About 88 (50%) of the participants were diagnosed with polycystic ovarian syndrome (cases), whereas other 50% belonged to control group. Data were collected using semi structured interview. Sexual satisfaction scale for women (SSS-W) was administered to measure sexual satisfaction level and psychiatric morbidity was assessed by Symptom Checklist-Revised. Results: Results showed that participant’s depression and anxiety level had significant negative correlation with their sexual satisfaction level, whereas, anxiety and depression shared a significant positive correlation. There was a significant difference in the scores for sexual satisfaction, depression and anxiety for both cases and controls. These results suggested that women suffering from polycystic ovarian syndrome tend to be less sexually satisfied and experienced relatively more symptoms of depression and anxiety as compared to controls. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=level%20of%20sexual%20satisfaction" title="level of sexual satisfaction">level of sexual satisfaction</a>, <a href="https://publications.waset.org/abstracts/search?q=psychiatric%20morbidity" title=" psychiatric morbidity"> psychiatric morbidity</a>, <a href="https://publications.waset.org/abstracts/search?q=polycystic%20ovarian%20syndrome" title=" polycystic ovarian syndrome"> polycystic ovarian syndrome</a> </p> <a href="https://publications.waset.org/abstracts/36350/sexual-satifaction-in-women-with-polycystic-ovarian-syndrome" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36350.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">462</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">173</span> Umbilical Epidermal Inclusion Cysts, a Rare Cause of Umbilical Mass: A Case Report and Review of Literature</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Christine%20Li">Christine Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Amanda%20Robertson"> Amanda Robertson</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Epidermal inclusion cysts occur when epidermal cells are implanted in the dermis following trauma, or surgery. They are a rare cause of an umbilical mass, with very few cases previously reported following abdominal surgery. These lesions can present with a range of symptoms, including palpable mass, pain, redness, or discharge. This paper reports a case of an umbilical epidermal inclusion cyst in a 52-year-old female presenting with a six-week history of a painful, red umbilical lump on a background of two previous diagnostic laparoscopies. Abdominal computed tomography (CT) scans revealed non-specific soft tissue thickening in the umbilical region. This was successfully treated with complete excision of the lesion. Umbilical lumps are a common presentation but can represent a diagnostic challenge. The differential diagnosis should include an epidermal inclusion cyst, particularly in a patient who has had previous abdominal surgery, including laparoscopic surgery. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epidermal%20inclusion%20cyst" title="epidermal inclusion cyst">epidermal inclusion cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=laparoscopy" title=" laparoscopy"> laparoscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=umbilical%20mass" title=" umbilical mass"> umbilical mass</a>, <a href="https://publications.waset.org/abstracts/search?q=umbilicus" title=" umbilicus"> umbilicus</a> </p> <a href="https://publications.waset.org/abstracts/138636/umbilical-epidermal-inclusion-cysts-a-rare-cause-of-umbilical-mass-a-case-report-and-review-of-literature" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138636.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">83</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">172</span> A Prenylflavanoid, HME5 with Antiproliferative Activity in Human Ovarian Cancer Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mashitoh%20Abd%20Rahman">Mashitoh Abd Rahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Najihah%20Mohd%20Hashim"> Najihah Mohd Hashim</a>, <a href="https://publications.waset.org/abstracts/search?q=Faiqah%20Ramli"> Faiqah Ramli</a>, <a href="https://publications.waset.org/abstracts/search?q=Syam%20Mohan"> Syam Mohan</a>, <a href="https://publications.waset.org/abstracts/search?q=Noraziah%20Nordin"> Noraziah Nordin</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamed%20Karimian"> Hamed Karimian</a>, <a href="https://publications.waset.org/abstracts/search?q=Hapipah%20Mohd%20Ali"> Hapipah Mohd Ali</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ovarian cancer is the most lethal gynecological malignancies. HME5, a prenylflavanoid has been isolated from local medicinal plant. This compound has been reported to possess a broad spectrum of biological activities including anticancer property. However, the potential of HME5 as an antiproliferative and cytotoxic agent on an ovarian cancer cells has not yet been investigated. In this present study, we examined the antiproliferative and cytotoxic effect of HME5 on Caov-3 (Human Ovarian Adenocarcinoma) cell line by using 3-[4,5-dimethylthizol-2-y]-2,5-diphenyltetrazolium bromide (MTT) assay, Acridine orange and propidium Iodide (AOPi) and cell cycle analysis study. HME5 has shown to inhibit Caov-3 in a time-dependent manner with the IC50 values of 5µg/ml, 2µg/ml and 1µg/ml after 24h, 48h and 72h treatment, respectively. Morphological study from AOPi analysis showed that HME5 induced apoptosis after 24 and 48h post-treatment. Nevertheless, HME5 exhibited cell cycle arrest at G1 phase as indicated in flow cytometry cell cycle profiling. In conclusion, HME5 inhibited proliferation of Caov-3 through induction of apoptosis and cell cycle arrest at G1 phase. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title="apoptosis">apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=prenylflavanoid" title=" prenylflavanoid"> prenylflavanoid</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=HME5" title=" HME5 "> HME5 </a> </p> <a href="https://publications.waset.org/abstracts/13503/a-prenylflavanoid-hme5-with-antiproliferative-activity-in-human-ovarian-cancer-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13503.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">461</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">171</span> Metastatic Ovarian Tumor Discovered Accidentally during Cesarean Section in a 34 Year Old Woman: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghada%20E.%20Esheba">Ghada E. Esheba</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghufran%20Kheshaifaty"> Ghufran Kheshaifaty</a>, <a href="https://publications.waset.org/abstracts/search?q=Kholoud%20%20Al-Harbi"> Kholoud Al-Harbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Wafa%27a%20Al-Harbi"> Wafa'a Al-Harbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ala%27a%20Al-Orabi"> Ala'a Al-Orabi</a>, <a href="https://publications.waset.org/abstracts/search?q=Moayad%20Turkistani"> Moayad Turkistani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Krukenberg tumor is a rare metastatic ovarian carcinoma that usually occurs in female between 30 - 40 year old and rarely seen after menopause. Stomach is the most common primary site. Histopathological features of krukenberg tumors appear as diffuse stromal proliferation, mucus-production, and numerous signet-cells and these tumors spread mostly by lymphatic route. Treatment and prognostic factors are not well established. This study describes a 34 year old female with a unilateral ovarian mass discovered accidentally during cesarean section delivery and it was misdiagnosed as luteoma of pregnancy, but histopathological examination showed a diffuse infiltration of the ovary and omentum by signet ring cells. These findings were not correlated with luteoma of pregnancy or any other types of primary ovarian tumors like surface epithelial tumor, sex cord stromal tumor or germ cell tumor. However, after the analysis of immunohistochemical results (negative CK7, positive CK20 and CDX-2), the finding was the diagnostic of metastatic krukenberg tumor. Two weeks later, the patient was evaluated and a large gastric tumor was found in her stomach and she underwent gastrectomy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CK7" title="CK7">CK7</a>, <a href="https://publications.waset.org/abstracts/search?q=CK20" title=" CK20"> CK20</a>, <a href="https://publications.waset.org/abstracts/search?q=CDX-2" title=" CDX-2"> CDX-2</a>, <a href="https://publications.waset.org/abstracts/search?q=Krukenburg%20tumor" title=" Krukenburg tumor"> Krukenburg tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=metastatic%20ovarian%20tumor" title=" metastatic ovarian tumor"> metastatic ovarian tumor</a> </p> <a href="https://publications.waset.org/abstracts/59354/metastatic-ovarian-tumor-discovered-accidentally-during-cesarean-section-in-a-34-year-old-woman-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59354.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">315</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">170</span> Anomalous Course of Left Ovarian Vein Associated with Pelvic Congestion Syndrome</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Viyango%20Pandian">Viyango Pandian</a>, <a href="https://publications.waset.org/abstracts/search?q=Kumaresh%20Athiyappan"> Kumaresh Athiyappan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Pelvic congestion Syndrome (PCS) is usually seen in multiparous women who give history of chronic dull-aching pelvic pain. We report a case of a 17 year old unmarried female, who presented with acute onset of chronic dull-aching abdominal pain in the left iliac fossa, which particularly increased during menstruation and was finally diagnosed to be pelvic congestion syndrome. On ultrasonography, multiple tortuous and dilated veins were observed in the left adnexa. Both ovaries appeared normal in size, volume and echotexture. Computed tomography (CT) angiography was performed to precisely delineate the venous pathway and to assess any associated abnormality; which showed a dilated and tortuous left ovarian vein with an anomalous course around the left kidney and draining into the left renal vein. Clinical parameters and hormonal levels were within normal limits. This is a rare case of anomalous course of left ovarian vein associated with pelvic congestion syndrome. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anomalous%20course%20of%20ovarian%20vein" title="anomalous course of ovarian vein">anomalous course of ovarian vein</a>, <a href="https://publications.waset.org/abstracts/search?q=computed%20tomography" title=" computed tomography"> computed tomography</a>, <a href="https://publications.waset.org/abstracts/search?q=pelvic%20congestion%20syndrome" title=" pelvic congestion syndrome"> pelvic congestion syndrome</a>, <a href="https://publications.waset.org/abstracts/search?q=ultrasonography" title=" ultrasonography"> ultrasonography</a> </p> <a href="https://publications.waset.org/abstracts/70992/anomalous-course-of-left-ovarian-vein-associated-with-pelvic-congestion-syndrome" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/70992.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">418</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">169</span> Exercise Intervention For Women After Treatment For Ovarian Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Deirdre%20Mc%20Grath">Deirdre Mc Grath</a>, <a href="https://publications.waset.org/abstracts/search?q=Joanne%20Reid"> Joanne Reid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Ovarian cancer is the leading cause of mortality among gynaecologic cancers in developed countries and the seventh most common cancer worldwide with nearly 240,000 women diagnosed each year. Although it is recognized engaging in exercise results in positive health care outcomes, women with ovarian cancer are reluctant to participate. No evidence currently exists focusing on how to successfully implement an exercise intervention program for patients with ovarian cancer, using a realist approach. There is a requirement for the implementation of exercise programmes within the oncology health care setting as engagement in such interventions has positive health care outcomes for women with ovarian cancer both during and following treatment. Aim: To co-design the implementation of an exercise intervention for women following treatment for ovarian cancer. Methods: This study is a realist evaluation using quantitative and qualitative methods of data collection and analysis. Realist evaluation is well-established within the health and social care setting and has in relation to this study enabled a flexible approach to investigate how to optimise implementation of an exercise intervention for this patient population. This single centre study incorporates three stages in order to identify the underlying contexts and mechanisms which lead to the successful implementation of an exercise intervention for women who have had treatment for ovarian cancer. Stage 1 - A realist literature review. Stage 2 -Co-design of the implementation of an exercise intervention with women following treatment for ovarian cancer, their carer’s, and health care professionals. Stage 3 –Implementation of an exercise intervention with women following treatment for ovarian cancer. Evaluation of the implementation of the intervention from the perspectives of the women who participated in the intervention, their informal carers, and health care professionals. The underlying program theory initially conceptualised before and during the realist review was developed further during the co-design stage. The evolving program theory in relation to how to successfully implement an exercise for these women is currently been refined and tested during the final stage of this realist evaluation which is the implementation and evaluation stage. Results: This realist evaluation highlights key issues in relation to the implementation of an exercise intervention within this patient population. The underlying contexts and mechanisms which influence recruitment, adherence, and retention rates of participants are identified. Conclusions: This study will inform future research on the implementation of exercise interventions for this patient population. It is anticipated that this intervention will be implemented into practice as part of standard care for this group of patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title="ovarian cancer">ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=exercise%20intervention" title=" exercise intervention"> exercise intervention</a>, <a href="https://publications.waset.org/abstracts/search?q=implementation" title=" implementation"> implementation</a>, <a href="https://publications.waset.org/abstracts/search?q=Co-design" title=" Co-design"> Co-design</a> </p> <a href="https://publications.waset.org/abstracts/143648/exercise-intervention-for-women-after-treatment-for-ovarian-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143648.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">186</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">168</span> Ectopic Pregnancy: A Case of Consecutive Occurrences of Different Types</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wania%20Mohammad%20Akram">Wania Mohammad Akram</a>, <a href="https://publications.waset.org/abstracts/search?q=Swetha%20Kannan"> Swetha Kannan</a>, <a href="https://publications.waset.org/abstracts/search?q=Urooj%20Shahid"> Urooj Shahid</a>, <a href="https://publications.waset.org/abstracts/search?q=Aisha%20Sajjad"> Aisha Sajjad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ovarian ectopic pregnancy, a rare manifestation of ectopic gestation, involves the implantation of a fertilized egg on the ovarian surface. This condition poses diagnostic challenges and is associated with significant maternal morbidity if not promptly managed. This report presents the case of a 33-year-old nulliparous woman with a history of polycystic ovary syndrome (PCOS) undergoing ovulation induction therapy. Following her first conception in October 2021, she presented with symptoms of per vaginal spotting and low back pain, prompting a diagnosis of left adnexal ectopic pregnancy confirmed by transvaginal ultrasound and serum beta-human chorionic gonadotropin (B-HCG) levels. Medical management with methotrexate was initiated successfully. In August 2022, the patient conceived again, with subsequent ultrasound revealing a large pelvic collection suggestive of a complex ectopic pregnancy involving both ovaries. Despite initial stability, she developed abdominal pain necessitating emergency laparoscopy, which revealed an ovarian ectopic pregnancy with hemoperitoneum. Laparotomy was performed due to the complexity of the presentation, and histopathology confirmed viable chorionic villi within ovarian tissue. This case underscores the clinical management challenges posed by ovarian ectopic pregnancies, particularly in patients with previous ectopic pregnancies. The discussion reviews current literature on diagnostic modalities, treatment strategies, and outcomes associated with ovarian ectopic pregnancies, emphasizing the role of surgical intervention in cases refractory to conservative management. Tailored approaches considering individual patient factors are crucial to optimize outcomes and preserve fertility in such complex scenarios. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=obgyn" title="obgyn">obgyn</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20ectopic%20pregnancy" title=" ovarian ectopic pregnancy"> ovarian ectopic pregnancy</a>, <a href="https://publications.waset.org/abstracts/search?q=laproscopy" title=" laproscopy"> laproscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=pcos" title=" pcos"> pcos</a> </p> <a href="https://publications.waset.org/abstracts/188354/ectopic-pregnancy-a-case-of-consecutive-occurrences-of-different-types" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188354.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> 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