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id="toc-Bioactivity-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Self-assembly" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Self-assembly"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Self-assembly</span> </div> </a> <ul id="toc-Self-assembly-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Structural_hierarchy" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Structural_hierarchy"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Structural hierarchy</span> </div> </a> <ul id="toc-Structural_hierarchy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Applications" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Applications"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Applications</span> </div> </a> <button aria-controls="toc-Applications-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Applications subsection</span> </button> <ul id="toc-Applications-sublist" class="vector-toc-list"> <li id="toc-Bone_grafts" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Bone_grafts"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Bone grafts</span> </div> </a> <ul id="toc-Bone_grafts-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Heart_valves" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Heart_valves"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Heart valves</span> </div> </a> <ul id="toc-Heart_valves-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Skin_repair" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Skin_repair"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.3</span> <span>Skin repair</span> </div> </a> <ul id="toc-Skin_repair-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Properties" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Properties"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Properties</span> </div> </a> <button aria-controls="toc-Properties-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Properties subsection</span> </button> <ul id="toc-Properties-sublist" class="vector-toc-list"> <li id="toc-Host_response" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Host_response"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Host response</span> </div> </a> <ul id="toc-Host_response-sublist" class="vector-toc-list"> <li id="toc-Biomaterial_and_tissue_interactions" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Biomaterial_and_tissue_interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1.1</span> <span>Biomaterial and tissue interactions</span> </div> </a> <ul id="toc-Biomaterial_and_tissue_interactions-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Compatibility" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Compatibility"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Compatibility</span> </div> </a> <ul id="toc-Compatibility-sublist" class="vector-toc-list"> <li id="toc-Toxicity" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Toxicity"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2.1</span> <span>Toxicity</span> </div> </a> <ul id="toc-Toxicity-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Biodegradable_biomaterials" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Biodegradable_biomaterials"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2.2</span> <span>Biodegradable biomaterials</span> </div> </a> <ul id="toc-Biodegradable_biomaterials-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Biocompatible_plastics" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Biocompatible_plastics"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2.3</span> <span>Biocompatible plastics</span> </div> </a> <ul id="toc-Biocompatible_plastics-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Surface_and_bulk_properties" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Surface_and_bulk_properties"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>Surface and bulk properties</span> </div> </a> <ul id="toc-Surface_and_bulk_properties-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mechanical_properties" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mechanical_properties"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.4</span> <span>Mechanical properties</span> </div> </a> <ul id="toc-Mechanical_properties-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Structure" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Structure</span> </div> </a> <button aria-controls="toc-Structure-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Structure subsection</span> </button> <ul id="toc-Structure-sublist" class="vector-toc-list"> <li id="toc-Atomic_structure" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Atomic_structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Atomic structure</span> </div> </a> <ul id="toc-Atomic_structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Microstructure" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Microstructure"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2</span> <span>Microstructure</span> </div> </a> <ul id="toc-Microstructure-sublist" class="vector-toc-list"> <li id="toc-Crystalline_structure" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Crystalline_structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2.1</span> <span>Crystalline structure</span> </div> </a> <ul id="toc-Crystalline_structure-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Defects_of_crystalline_structure" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Defects_of_crystalline_structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2.2</span> <span>Defects of crystalline structure</span> </div> </a> <ul id="toc-Defects_of_crystalline_structure-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Macrostructure" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Macrostructure"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.3</span> <span>Macrostructure</span> </div> </a> <ul id="toc-Macrostructure-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Natural_biomaterials" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Natural_biomaterials"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Natural biomaterials</span> </div> </a> <button aria-controls="toc-Natural_biomaterials-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Natural biomaterials subsection</span> </button> <ul id="toc-Natural_biomaterials-sublist" class="vector-toc-list"> <li id="toc-Biopolymers" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Biopolymers"> <div class="vector-toc-text"> <span class="vector-toc-numb">8.1</span> <span>Biopolymers</span> </div> </a> <ul id="toc-Biopolymers-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Footnotes" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Footnotes"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>Footnotes</span> </div> </a> <ul id="toc-Footnotes-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">12</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav 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id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Biomaterial</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 28 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-28" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">28 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%A7%D8%AF%D8%A9_%D8%AD%D9%8A%D9%88%D9%8A%D8%A9" title="مادة حيوية – Arabic" lang="ar" hreflang="ar" data-title="مادة حيوية" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Biomaterial" title="Biomaterial – Catalan" lang="ca" hreflang="ca" data-title="Biomaterial" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Biomaterial" title="Biomaterial – German" lang="de" hreflang="de" data-title="Biomaterial" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Biomaterjal" title="Biomaterjal – Estonian" lang="et" hreflang="et" data-title="Biomaterjal" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Biomaterial" title="Biomaterial – Spanish" lang="es" hreflang="es" data-title="Biomaterial" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Biomaterialo" title="Biomaterialo – Esperanto" lang="eo" hreflang="eo" data-title="Biomaterialo" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A8%DB%8C%D9%88%D9%85%D8%AA%D8%B1%DB%8C%D8%A7%D9%84" title="بیومتریال – Persian" lang="fa" hreflang="fa" data-title="بیومتریال" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Biomat%C3%A9riau" title="Biomatériau – French" lang="fr" hreflang="fr" data-title="Biomatériau" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%83%9D%EC%B2%B4_%EC%9E%AC%EB%A3%8C" title="생체 재료 – Korean" lang="ko" hreflang="ko" data-title="생체 재료" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%9C%E0%A5%88%E0%A4%B5%E0%A4%B8%E0%A4%BE%E0%A4%AE%E0%A4%97%E0%A5%8D%E0%A4%B0%E0%A5%80" title="जैवसामग्री – Hindi" lang="hi" hreflang="hi" data-title="जैवसामग्री" data-language-autonym="हिन्दी" data-language-local-name="Hindi" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Biomaterial" title="Biomaterial – Indonesian" lang="id" hreflang="id" data-title="Biomaterial" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Biomateriale" title="Biomateriale – Italian" lang="it" hreflang="it" data-title="Biomateriale" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Biobahan" title="Biobahan – Malay" lang="ms" hreflang="ms" data-title="Biobahan" data-language-autonym="Bahasa Melayu" data-language-local-name="Malay" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-min mw-list-item"><a href="https://min.wikipedia.org/wiki/Biomaterial" title="Biomaterial – Minangkabau" lang="min" hreflang="min" data-title="Biomaterial" data-language-autonym="Minangkabau" data-language-local-name="Minangkabau" class="interlanguage-link-target"><span>Minangkabau</span></a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%91%D0%B8%D0%BE%D0%BC%D0%B0%D1%82%D0%B5%D1%80%D0%B8%D0%B0%D0%BB" title="Биоматериал – Mongolian" lang="mn" hreflang="mn" data-title="Биоматериал" data-language-autonym="Монгол" data-language-local-name="Mongolian" class="interlanguage-link-target"><span>Монгол</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Biomateriaal" title="Biomateriaal – Dutch" lang="nl" hreflang="nl" data-title="Biomateriaal" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E7%94%9F%E4%BD%93%E6%9D%90%E6%96%99" title="生体材料 – Japanese" lang="ja" hreflang="ja" data-title="生体材料" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Biomateriale" title="Biomateriale – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Biomateriale" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Biomateria%C5%82" title="Biomateriał – Polish" lang="pl" hreflang="pl" data-title="Biomateriał" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Biomaterial" title="Biomaterial – Portuguese" lang="pt" hreflang="pt" data-title="Biomaterial" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Biomaterial" title="Biomaterial – Romanian" lang="ro" hreflang="ro" data-title="Biomaterial" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Biomaterial" title="Biomaterial – Slovenian" lang="sl" hreflang="sl" data-title="Biomaterial" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%91%D0%B8%D0%BE%D0%BC%D0%B0%D1%82%D0%B5%D1%80%D0%B8%D1%98%D0%B0%D0%BB" title="Биоматеријал – Serbian" lang="sr" hreflang="sr" data-title="Биоматеријал" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Biomateriaalit" title="Biomateriaalit – Finnish" lang="fi" hreflang="fi" data-title="Biomateriaalit" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Biomassa" title="Biomassa – Swedish" lang="sv" hreflang="sv" data-title="Biomassa" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%A7%E0%B8%B1%E0%B8%AA%E0%B8%94%E0%B8%B8%E0%B8%8A%E0%B8%B5%E0%B8%A7%E0%B8%A0%E0%B8%B2%E0%B8%9E" title="วัสดุชีวภาพ – Thai" lang="th" hreflang="th" data-title="วัสดุชีวภาพ" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Biyomateryal" title="Biyomateryal – Turkish" lang="tr" hreflang="tr" data-title="Biyomateryal" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%91%D1%96%D0%BE%D0%BC%D0%B0%D1%82%D0%B5%D1%80%D1%96%D0%B0%D0%BB%D0%B8" title="Біоматеріали – Ukrainian" lang="uk" hreflang="uk" data-title="Біоматеріали" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q865663#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Biomaterial" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li 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<div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Any substance that has been engineered to interact with biological systems for a medical purpose</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">"Biomaterials" redirects here. For the journal, see <a href="/wiki/Biomaterials_(journal)" title="Biomaterials (journal)">Biomaterials (journal)</a>.</div> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Hip_joint_replacement,_United_States,_1998_Wellcome_L0060175.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/Hip_joint_replacement%2C_United_States%2C_1998_Wellcome_L0060175.jpg/220px-Hip_joint_replacement%2C_United_States%2C_1998_Wellcome_L0060175.jpg" decoding="async" width="220" height="146" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/Hip_joint_replacement%2C_United_States%2C_1998_Wellcome_L0060175.jpg/330px-Hip_joint_replacement%2C_United_States%2C_1998_Wellcome_L0060175.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/47/Hip_joint_replacement%2C_United_States%2C_1998_Wellcome_L0060175.jpg/440px-Hip_joint_replacement%2C_United_States%2C_1998_Wellcome_L0060175.jpg 2x" data-file-width="4256" data-file-height="2832" /></a><figcaption>A <a href="/wiki/Hip_implant" class="mw-redirect" title="Hip implant">hip implant</a> is an example of an application of biomaterials</figcaption></figure> <p>A <b>biomaterial</b> is a substance that has been <a href="/wiki/Biological_engineering" title="Biological engineering">engineered</a> to interact with <a href="/wiki/Biological_system" title="Biological system">biological systems</a> for a medical purpose – either a therapeutic (treat, augment, repair, or replace a tissue function of the body) or a <a href="/wiki/Medical_diagnosis" title="Medical diagnosis">diagnostic</a> one. The corresponding field of study, called <b>biomaterials science</b> or <b>biomaterials engineering</b>, is about fifty years old.<sup class="noprint Inline-Template" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Manual_of_Style/Dates_and_numbers#Chronological_items" title="Wikipedia:Manual of Style/Dates and numbers"><span title="Add Time ago template as well (March 2024)">needs update</span></a></i>]</sup> It has experienced steady growth over its history, with many companies investing large amounts of money into the development of new products. Biomaterials science encompasses elements of <a href="/wiki/Medicine" title="Medicine">medicine</a>, <a href="/wiki/Biology" title="Biology">biology</a>, <a href="/wiki/Chemistry" title="Chemistry">chemistry</a>, <a href="/wiki/Tissue_engineering" title="Tissue engineering">tissue engineering</a> and <a href="/wiki/Materials_science" title="Materials science">materials science</a>. </p><p>A biomaterial is different from a biological material, such as <a href="/wiki/Bone" title="Bone">bone</a>, that is produced by a <a href="/wiki/Biological_system" title="Biological system">biological system</a>. However, "biomaterial" and "biological material" are often used interchangeably. Further, the word "bioterial" has been proposed as a potential alternate word for biologically-produced materials such as bone, or fungal biocomposites.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (March 2023)">citation needed</span></a></i>]</sup> Additionally, care should be exercised in defining a biomaterial as <a href="/wiki/Biocompatibility" title="Biocompatibility">biocompatible</a>, since it is application-specific. A biomaterial that is biocompatible or suitable for one application may not be biocompatible in another.<sup id="cite_ref-SchmalzBio08_1-0" class="reference"><a href="#cite_note-SchmalzBio08-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <style data-mw-deduplicate="TemplateStyles:r1224211176">.mw-parser-output .quotebox{background-color:#F9F9F9;border:1px solid #aaa;box-sizing:border-box;padding:10px;font-size:88%;max-width:100%}.mw-parser-output .quotebox.floatleft{margin:.5em 1.4em .8em 0}.mw-parser-output .quotebox.floatright{margin:.5em 0 .8em 1.4em}.mw-parser-output .quotebox.centered{overflow:hidden;position:relative;margin:.5em auto .8em auto}.mw-parser-output .quotebox.floatleft span,.mw-parser-output .quotebox.floatright span{font-style:inherit}.mw-parser-output .quotebox>blockquote{margin:0;padding:0;border-left:0;font-family:inherit;font-size:inherit}.mw-parser-output .quotebox-title{text-align:center;font-size:110%;font-weight:bold}.mw-parser-output .quotebox-quote>:first-child{margin-top:0}.mw-parser-output .quotebox-quote:last-child>:last-child{margin-bottom:0}.mw-parser-output .quotebox-quote.quoted:before{font-family:"Times New Roman",serif;font-weight:bold;font-size:large;color:gray;content:" “ ";vertical-align:-45%;line-height:0}.mw-parser-output .quotebox-quote.quoted:after{font-family:"Times New Roman",serif;font-weight:bold;font-size:large;color:gray;content:" ” ";line-height:0}.mw-parser-output .quotebox .left-aligned{text-align:left}.mw-parser-output .quotebox .right-aligned{text-align:right}.mw-parser-output .quotebox .center-aligned{text-align:center}.mw-parser-output .quotebox .quote-title,.mw-parser-output .quotebox .quotebox-quote{display:block}.mw-parser-output .quotebox cite{display:block;font-style:normal}@media screen and (max-width:640px){.mw-parser-output .quotebox{width:100%!important;margin:0 0 .8em!important;float:none!important}}</style><div class="quotebox pullquote floatright" style=";"> <div class="quotebox-title" style=""><a href="/wiki/International_Union_of_Pure_and_Applied_Chemistry" title="International Union of Pure and Applied Chemistry">IUPAC</a> definition</div> <blockquote class="quotebox-quote left-aligned" style=""> <p><i>Material</i> exploited in contact with living tissues, organisms, or microorganisms.<sup id="cite_ref-IUPAC_2-0" class="reference"><a href="#cite_note-IUPAC-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>a<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>b<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>c<span class="cite-bracket">]</span></a></sup> </p> </blockquote> </div> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Introduction">Introduction</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=1" title="Edit section: Introduction"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Biomaterials can be derived either from nature or <a href="/wiki/Biosynthesis" title="Biosynthesis">synthesized</a> in the laboratory using a variety of chemical approaches utilizing metallic components, <a href="/wiki/Polymers" class="mw-redirect" title="Polymers">polymers</a>, <a href="/wiki/Bioceramic" title="Bioceramic">ceramics</a> or <a href="/wiki/Composite_materials" class="mw-redirect" title="Composite materials">composite materials</a>. They are often used and/or adapted for a medical application, and thus comprise the whole or part of a living structure or biomedical device which performs, augments, or replaces a natural function. Such functions may be relatively passive, like being used for a <a href="/wiki/Heart_valve" title="Heart valve">heart valve</a>, or maybe <a href="/wiki/Biological_activity" title="Biological activity">bioactive</a> with a more interactive functionality such as <a href="/wiki/Hydroxylapatite" class="mw-redirect" title="Hydroxylapatite">hydroxy-apatite</a> coated <a href="/wiki/Hip_implant" class="mw-redirect" title="Hip implant">hip implants</a>. Biomaterials are also commonly used in dental applications, surgery, and drug delivery. For example, a construct with impregnated pharmaceutical products can be placed into the body, which permits the prolonged release of a drug over an extended period of time. A biomaterial may also be an <a href="/wiki/Autograft" class="mw-redirect" title="Autograft">autograft</a>, <a href="/wiki/Allograft" class="mw-redirect" title="Allograft">allograft</a> or <a href="/wiki/Xenograft" class="mw-redirect" title="Xenograft">xenograft</a> used as a <a href="/wiki/Organ_transplant" class="mw-redirect" title="Organ transplant">transplant</a> material.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (August 2020)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Bioactivity">Bioactivity</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=2" title="Edit section: Bioactivity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The ability of an engineered biomaterial to induce a physiological response that is supportive of the biomaterial's function and performance is known as bioactivity. Most commonly, in <a href="/wiki/Bioactive_glass" title="Bioactive glass">bioactive glasses</a> and bioactive ceramics this term refers to the ability of implanted materials to bond well with surrounding tissue in either osteo conductive or osseo productive roles.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Bone implant materials are often designed to promote bone growth while dissolving into surrounding body fluid.<sup id="cite_ref-SDHA_8-0" class="reference"><a href="#cite_note-SDHA-8"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Thus for many biomaterials good biocompatibility along with good strength and dissolution rates are desirable. Commonly, bioactivity of biomaterials is gauged by the surface biomineralization in which a native layer of <a href="/wiki/Hydroxyapatite" title="Hydroxyapatite">hydroxyapatite</a> is formed at the surface. These days, the development of clinically useful biomaterials is greatly enhanced by the advent of computational routines that can predict the molecular effects of biomaterials in a therapeutic setting based on limited <i>in vitro</i> experimentation.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Self-assembly">Self-assembly</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=3" title="Edit section: Self-assembly"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Self-assembly" title="Self-assembly">Self-assembly</a> is the most common term in use in the modern scientific community to describe the spontaneous aggregation of particles (atoms, molecules, <a href="/wiki/Colloids" class="mw-redirect" title="Colloids">colloids</a>, <a href="/wiki/Micelles" class="mw-redirect" title="Micelles">micelles</a>, etc.) without the influence of any external forces. Large groups of such particles are known to assemble themselves into <a href="/wiki/Thermodynamic" class="mw-redirect" title="Thermodynamic">thermodynamically</a> stable, structurally well-defined arrays, quite reminiscent of one of the seven crystal systems found in <a href="/wiki/Metallurgy" title="Metallurgy">metallurgy</a> and <a href="/wiki/Mineralogy" title="Mineralogy">mineralogy</a> (e.g., face-centered cubic, body-centered cubic, etc.). The fundamental difference in equilibrium structure is in the spatial scale of the <a href="/wiki/Unit_cell" title="Unit cell">unit cell</a> (lattice parameter) in each particular case. </p><p>Molecular self assembly is found widely in biological systems and provides the basis of a wide variety of complex biological structures. This includes an emerging class of mechanically superior biomaterials based on microstructural features and designs found in nature. Thus, self-assembly is also emerging as a new strategy in chemical synthesis and <a href="/wiki/Nanotechnology" title="Nanotechnology">nanotechnology</a>. Molecular crystals, liquid crystals, colloids, micelles, <a href="/wiki/Emulsions" class="mw-redirect" title="Emulsions">emulsions</a>, phase-separated polymers, thin films and self-assembled monolayers all represent examples of the types of highly ordered structures, which are obtained using these techniques. The distinguishing feature of these methods is self-organization.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structural_hierarchy">Structural hierarchy</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=4" title="Edit section: Structural hierarchy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nearly all materials could be seen as hierarchically structured, since the changes in spatial scale bring about different mechanisms of deformation and damage.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> However, in biological materials, this hierarchical organization is inherent to the microstructure. One of the first examples of this, in the history of structural biology, is the early <a href="/wiki/X-ray_scattering_techniques" title="X-ray scattering techniques">X-ray scattering</a> work on the hierarchical structure of <a href="/wiki/Hair" title="Hair">hair</a> and <a href="/wiki/Wool" title="Wool">wool</a> by Astbury and Woods.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> In bone, for example, <a href="/wiki/Collagen" title="Collagen">collagen</a> is the building block of the <a href="/wiki/Matrix_(biology)" title="Matrix (biology)">organic matrix</a>, a triple helix with diameter of 1.5 nm. These <a href="/wiki/Tropocollagen" class="mw-redirect" title="Tropocollagen">tropocollagen</a> molecules are <a href="/wiki/Intercalation_(chemistry)" title="Intercalation (chemistry)">intercalated</a> with the mineral phase (<a href="/wiki/Hydroxyapatite" title="Hydroxyapatite">hydroxyapatite</a>, calcium phosphate) forming <a href="/wiki/Fibril" title="Fibril">fibrils</a> that curl into <a href="/wiki/Helicoid" title="Helicoid">helicoids</a> of alternating directions. These "<a href="/wiki/Osteon" title="Osteon">osteons</a>" are the basic building blocks of bones, with the volume fraction distribution between organic and mineral phase being about 60/40. </p><p>In another level of complexity, the hydroxyapatite crystals are mineral platelets that have a diameter of approximately 70 to 100 nm and thickness of 1 nm. They originally nucleate at the gaps between collagen fibrils.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>Similarly, the hierarchy of <a href="/wiki/Abalone" title="Abalone">abalone</a> shell begins at the nanolevel, with an organic layer having a thickness of 20 to 30 nm. This layer proceeds with single crystals of <a href="/wiki/Aragonite" title="Aragonite">aragonite</a> (a polymorph of CaCO<sub>3</sub>) consisting of "bricks" with dimensions of 0.5 and finishing with layers approximately 0.3 mm (mesostructure).<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Crab" title="Crab">Crabs</a> are arthropods, whose carapace is made of a mineralized hard component (exhibits brittle fracture) and a softer organic component composed primarily of <a href="/wiki/Chitin" title="Chitin">chitin</a>. The brittle component is arranged in a helical pattern. Each of these mineral "rods" (1 μm diameter) contains chitin–protein fibrils with approximately 60 nm diameter. These fibrils are made of 3 nm diameter canals that link the interior and exterior of the shell. </p> <div class="mw-heading mw-heading2"><h2 id="Applications">Applications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=5" title="Edit section: Applications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Biomaterials are used in: </p> <ol><li><a href="/wiki/Joint_replacements" class="mw-redirect" title="Joint replacements">Joint replacements</a></li> <li>Bone plates <sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Intraocular_lens" title="Intraocular lens">Intraocular lenses</a> (IOLs) for eye surgery</li> <li><a href="/wiki/Bone_cement" title="Bone cement">Bone cement</a></li> <li>Artificial ligaments and tendons</li> <li><a href="/wiki/Dental_implants" class="mw-redirect" title="Dental implants">Dental implants</a> for tooth fixation</li> <li>Blood vessel prostheses</li> <li><a href="/wiki/Heart_valves" class="mw-redirect" title="Heart valves">Heart valves</a></li> <li>Skin repair devices (artificial tissue)</li> <li>Cochlear replacements</li> <li><a href="/wiki/Contact_lenses" class="mw-redirect" title="Contact lenses">Contact lenses</a></li> <li><a href="/wiki/Breast_implants" class="mw-redirect" title="Breast implants">Breast implants</a></li> <li>Drug delivery mechanisms</li> <li>Sustainable materials</li> <li>Vascular grafts</li> <li><a href="/wiki/Stents" class="mw-redirect" title="Stents">Stents</a></li> <li>Nerve conduits</li> <li><a href="/wiki/Surgical_sutures" class="mw-redirect" title="Surgical sutures">Surgical sutures</a>, clips, and staples for <a href="/wiki/Wound#Closure" title="Wound">wound closure</a><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup></li> <li>Pins and screws for fracture stabilisation<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Surgical_mesh" title="Surgical mesh">Surgical mesh</a><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li></ol> <p>Biomaterials must be compatible with the body, and there are often issues of <a href="/wiki/Biocompatibility" title="Biocompatibility">biocompatibility</a>, which must be resolved before a product can be placed on the market and used in a <a href="/wiki/Clinic" title="Clinic">clinical</a> setting. Because of this, biomaterials are usually subjected to the same requirements as those undergone by new <a href="/wiki/Drug" title="Drug">drug</a> therapies.<sup id="cite_ref-Meyers08_22-0" class="reference"><a href="#cite_note-Meyers08-22"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Espinosa09_23-0" class="reference"><a href="#cite_note-Espinosa09-23"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> All manufacturing companies are also required to ensure traceability of all of their products, so that if a defective product is discovered, others in the same batch may be traced. </p> <div class="mw-heading mw-heading3"><h3 id="Bone_grafts">Bone grafts</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=6" title="Edit section: Bone grafts"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Calcium_sulfate" title="Calcium sulfate">Calcium sulfate</a> (its α- and β-hemihydrates) is a well known biocompatible material that is widely used as a <a href="/wiki/Bone_grafting" title="Bone grafting">bone graft</a> substitute in <a href="/wiki/Dentistry" title="Dentistry">dentistry</a> or as its binder.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Heart_valves">Heart valves</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=7" title="Edit section: Heart valves"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In the United States, 49% of the 250,000 valve replacement procedures performed annually involve a mechanical valve implant. The most widely used valve is a bileaflet disc heart valve or St. Jude valve. The mechanics involve two semicircular discs moving back and forth, with both allowing the flow of blood as well as the ability to form a seal against backflow. The valve is coated with pyrolytic carbon and secured to the surrounding tissue with a mesh of woven fabric called Dacron (du Pont's trade name for <a href="/wiki/Polyethylene_terephthalate" title="Polyethylene terephthalate">polyethylene terephthalate</a>). The mesh allows for the body's tissue to grow, while incorporating the valve.<sup id="cite_ref-Chemistry_Textbook_26-0" class="reference"><a href="#cite_note-Chemistry_Textbook-26"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Skin_repair">Skin repair</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=8" title="Edit section: Skin repair"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Tissue_engineering" title="Tissue engineering">Tissue engineering</a></div> <p>Most of the time, artificial tissue is grown from the patient's own cells. However, when the damage is so extreme that it is impossible to use the patient's own cells, artificial tissue cells are grown. The difficulty is in finding a scaffold that the cells can grow and organize on. The characteristics of the scaffold must be that it is biocompatible, cells can adhere to the scaffold, mechanically strong and <a href="/wiki/Biodegradable" class="mw-redirect" title="Biodegradable">biodegradable</a>. One successful scaffold is a <a href="/wiki/Copolymer" title="Copolymer">copolymer</a> of <a href="/wiki/Lactic_acid" title="Lactic acid">lactic acid</a> and <a href="/wiki/Glycolic_acid" title="Glycolic acid">glycolic acid</a>.<sup id="cite_ref-Chemistry_Textbook_26-1" class="reference"><a href="#cite_note-Chemistry_Textbook-26"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Properties">Properties</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=9" title="Edit section: Properties"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>As discussed previously, biomaterials are used in medical devices to treat, assist, or replace a function within the human body. The application of a specific biomaterial must combine the necessary composition, material properties, structure, and desired <a href="/wiki/In_vivo" title="In vivo">in vivo</a> reaction in order to perform the desired function. Categorizations of different desired properties are defined in order to maximize functional results.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:0_28-0" class="reference"><a href="#cite_note-:0-28"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Host_response">Host response</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=10" title="Edit section: Host response"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Host response is defined as the "response of the host organism (local and systemic) to the implanted material or device". Most materials will have a reaction when in contact with the human body. The success of a biomaterial relies on the host tissue's reaction with the foreign material. Specific reactions between the host tissue and the biomaterial can be generated through the <a href="/wiki/Biocompatibility" title="Biocompatibility">biocompatibility</a> of the material.<sup id="cite_ref-:0_28-1" class="reference"><a href="#cite_note-:0-28"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Biomaterial_and_tissue_interactions">Biomaterial and tissue interactions</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=11" title="Edit section: Biomaterial and tissue interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/In_vivo" title="In vivo">in vivo</a> functionality and longevity of any implantable <a href="/wiki/Medical_device" title="Medical device">medical device</a> is affected by the body's response to the foreign material.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> The body undergoes a cascade of processes defined under the <a href="/wiki/Foreign_body_response" class="mw-redirect" title="Foreign body response">foreign body response</a> (FBR) in order to protect the host from the foreign material. The interactions between the device upon the host tissue/blood as well as the host tissue/blood upon the device must be understood in order to prevent complications and device failure. </p><p>Tissue injury caused by device implantation causes <a href="/wiki/Inflammation" title="Inflammation">inflammatory</a> and healing responses during FBR. The inflammatory response occurs within two time periods: the acute phase, and the chronic phase. The acute phase occurs during the initial hours to days of implantation, and is identified by fluid and protein exudation<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> along with a neutrophilic reaction.<sup id="cite_ref-:1_32-0" class="reference"><a href="#cite_note-:1-32"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> During the acute phase, the body attempts to clean and heal the wound by delivering excess blood, proteins, and monocytes are called to the site.<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> Continued inflammation leads to the chronic phase, which can be categorized by the presence of monocytes, macrophages, and lymphocytes.<sup id="cite_ref-:1_32-1" class="reference"><a href="#cite_note-:1-32"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> In addition, blood vessels and connective tissue form in order to heal the wounded area.<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Compatibility">Compatibility</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=12" title="Edit section: Compatibility"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Biocompatibility" title="Biocompatibility">Biocompatibility</a> is related to the behavior of biomaterials in various environments under various chemical and physical conditions. The term may refer to specific properties of a material without specifying where or how the material is to be used. For example, a material may elicit little or no <a href="/wiki/Immune_response" title="Immune response">immune response</a> in a given organism, and may or may not able to integrate with a particular cell type or <a href="/wiki/Tissue_(biology)" title="Tissue (biology)">tissue</a>. Immuno-informed biomaterials that direct the immune response rather than attempting to circumvent the process is one approach that shows promise.<sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> The ambiguity of the term reflects the ongoing development of insights into "how biomaterials interact with the <a href="/wiki/Human_body" title="Human body">human body</a>" and eventually "how those interactions determine the clinical success of a <a href="/wiki/Medical_device" title="Medical device">medical device</a> (such as <a href="/wiki/Pacemaker" title="Pacemaker">pacemaker</a> or <a href="/wiki/Hip_replacement" title="Hip replacement">hip replacement</a>)". Modern medical devices and <a href="/wiki/Prostheses" class="mw-redirect" title="Prostheses">prostheses</a> are often made of more than one material, so it might not always be sufficient to talk about the biocompatibility of a specific material.<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> Surgical implantation of a biomaterial into the body triggers an organism-inflammatory reaction with the associated healing of the damaged tissue. Depending upon the composition of the implanted material, the surface of the implant, the mechanism of fatigue, and chemical decomposition there are several other reactions possible. These can be local as well as systemic. These include immune response, foreign body reaction with the isolation of the implant with a vascular connective tissue, possible infection, and impact on the lifespan of the implant. <a href="/wiki/Graft-versus-host_disease" title="Graft-versus-host disease">Graft-versus-host disease</a> is an auto- and alloimmune disorder, exhibiting a variable clinical course. It can manifest in either acute or chronic form, affecting multiple organs and tissues and causing serious complications in clinical practice, both during transplantation and implementation of biocompatible materials.<sup id="cite_ref-VelnarBunc2016_37-0" class="reference"><a href="#cite_note-VelnarBunc2016-37"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Toxicity">Toxicity</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=13" title="Edit section: Toxicity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A biomaterial should perform its intended function within the living body without negatively affecting other bodily tissues and organs. In order to prevent unwanted organ and tissue interactions, biomaterials should be <a href="/wiki/Non-toxic" class="mw-redirect" title="Non-toxic">non-toxic</a>. The toxicity of a biomaterial refers to the substances that are emitted from the biomaterial while <a href="/wiki/In_vivo" title="In vivo">in vivo</a>. A biomaterial should not give off anything to its environment unless it is intended to do so. Nontoxicity means that biomaterial is: noncarcinogenic, <a href="/wiki/Nonpyogenic" class="mw-redirect" title="Nonpyogenic">nonpyrogenic</a>, <a href="/wiki/Non-allergenic" class="mw-redirect" title="Non-allergenic">nonallergenic</a>, blood compatible, and <a href="/wiki/Non-inflammatory_acne" class="mw-redirect" title="Non-inflammatory acne">noninflammatory</a>.<sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> However, a biomaterial can be designed to include toxicity for an intended purpose. For example, application of toxic biomaterial is studied during <a href="/wiki/In_vivo" title="In vivo">in vivo</a> and <a href="/wiki/In_vitro" title="In vitro">in vitro</a> <a href="/wiki/Cancer_immunotherapy" title="Cancer immunotherapy">cancer immunotherapy</a> testing. Toxic biomaterials offer an opportunity to manipulate and control cancer cells.<sup id="cite_ref-39" class="reference"><a href="#cite_note-39"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> One recent study states: "Advanced nanobiomaterials, including <a href="/wiki/Liposome" title="Liposome">liposomes</a>, <a href="/wiki/Polymer" title="Polymer">polymers</a>, and <a href="/wiki/Silica_gel" title="Silica gel">silica</a>, play a vital role in the codelivery of drugs and <a href="/wiki/Immunomodulators" class="mw-redirect" title="Immunomodulators">immunomodulators</a>. These nanobiomaterial-based delivery systems could effectively promote antitumor immune responses and simultaneously reduce toxic adverse effects."<sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> This is a prime example of how the biocompatibility of a biomaterial can be altered to produce any desired function. </p> <div class="mw-heading mw-heading4"><h4 id="Biodegradable_biomaterials">Biodegradable biomaterials</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=14" title="Edit section: Biodegradable biomaterials"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Biodegradable biomaterials refers to materials that are degradable through natural <a href="/wiki/Enzymatic_Reactions" class="mw-redirect" title="Enzymatic Reactions">enzymatic reactions</a>. The application of biodegradable synthetic polymers began in the later 1960s.<sup id="cite_ref-Song_3117–3145_41-0" class="reference"><a href="#cite_note-Song_3117–3145-41"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> Biodegradable materials have an advantage over other materials, as they have lower risk of harmful effects long term. In addition to ethical advancements using biodegradable materials, they also improve biocompatibility for materials used for implantation.<sup id="cite_ref-Song_3117–3145_41-1" class="reference"><a href="#cite_note-Song_3117–3145-41"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> Several properties including biocompatibility are important when considering different biodegradable biomaterials. Biodegradable biomaterials can be synthetic or natural depending on their source and type of extracellular matrix (ECM).<sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Biocompatible_plastics">Biocompatible plastics</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=15" title="Edit section: Biocompatible plastics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Some of the most commonly-used <a href="/wiki/Biocompatibility" title="Biocompatibility">biocompatible</a> materials (or biomaterials) are polymers due to their inherent flexibility and tunable <a href="/wiki/Mechanical_properties" class="mw-redirect" title="Mechanical properties">mechanical properties</a>. Medical devices made of plastics are often made of a select few including: <a href="/wiki/Cyclic_olefin_polymer" title="Cyclic olefin polymer">cyclic olefin polymer</a> (COP), <a href="/wiki/Cyclic_olefin_copolymer" title="Cyclic olefin copolymer">cyclic olefin copolymer</a> (COC), <a href="/wiki/Polycarbonate" title="Polycarbonate">polycarbonate</a> (PC), <a href="/wiki/Polyimide" title="Polyimide">polyetherimide</a> (PEI), medical grade <a href="/wiki/Polyvinyl_chloride" title="Polyvinyl chloride">polyvinylchloride</a> (PVC), <a href="/wiki/Polysulfone" title="Polysulfone">polyethersulfone</a> (PES), <a href="/wiki/Polyethylene" title="Polyethylene">polyethylene</a> (PE), <a href="/wiki/Polyether_ether_ketone" title="Polyether ether ketone">polyetheretherketone</a> (PEEK) and even <a href="/wiki/Polypropylene" title="Polypropylene">polypropylene</a> (PP). To ensure <a href="/wiki/Biocompatibility" title="Biocompatibility">biocompatibility</a>, there are a series of regulated tests that material must pass to be certified for use. These include the United States Pharmacopoeia IV (USP Class IV) Biological Reactivity Test and the International Standards Organization 10993 (ISO 10993) Biological Evaluation of Medical Devices. The main objective of biocompatibility tests is to quantify the acute and chronic toxicity of material and determine any potential adverse effects during use conditions, thus the tests required for a given material are dependent on its end-use (i.e. blood, central nervous system, etc.).<sup id="cite_ref-43" class="reference"><a href="#cite_note-43"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Surface_and_bulk_properties">Surface and bulk properties</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=16" title="Edit section: Surface and bulk properties"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Two properties that have a large effect on the functionality of a biomaterial is the <i>surface</i> and <i>bulk properties</i>.<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> </p><p><i>Bulk properties</i> refers to the physical and chemical properties that compose the biomaterial for its entire lifetime. They can be specifically generated to mimic the physiochemical properties of the tissue that the material is replacing. They are mechanical properties that are generated from a material's atomic and molecular construction. </p><p>Important bulk properties:<sup id="cite_ref-45" class="reference"><a href="#cite_note-45"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Chemical_composition" title="Chemical composition">Chemical Composition</a></li> <li><a href="/wiki/Microstructure" title="Microstructure">Microstructure</a></li> <li><a href="/wiki/Elasticity_(physics)" title="Elasticity (physics)">Elasticity</a></li> <li><a href="/wiki/Tensile_strength" class="mw-redirect" title="Tensile strength">Tensile Strength</a></li> <li><a href="/wiki/Density" title="Density">Density</a></li> <li><a href="/wiki/Hardness" title="Hardness">Hardness</a></li> <li><a href="/wiki/Electrical_conductivity" class="mw-redirect" title="Electrical conductivity">Electrical Conductivity</a></li> <li><a href="/wiki/Thermal_conductivity" class="mw-redirect" title="Thermal conductivity">Thermal Conductivity</a></li></ul> <p><i>Surface properties</i> refers to the chemical and topographical features on the surface of the biomaterial that will have direct interaction with the host blood/tissue.<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> Surface engineering and modification allows clinicians to better control the interactions of a biomaterial with the host living system. </p><p>Important surface properties:<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Wettability" class="mw-redirect" title="Wettability">Wettability</a> (surface energy)</li> <li>Surface chemistry</li> <li>Surface textures (smooth/rough) <ul><li>Topographical factors including: size, shape, alignment, structure determine the roughness of a material.<sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup></li></ul></li> <li><a href="/wiki/Surface_tension" title="Surface tension">Surface Tension</a></li> <li><a href="/wiki/Surface_charge" title="Surface charge">Surface Charge</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Mechanical_properties">Mechanical properties</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=17" title="Edit section: Mechanical properties"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In addition to a material being certified as <a href="/wiki/Biocompatibility" title="Biocompatibility">biocompatible</a>, biomaterials must be engineered specifically to their target application within a <a href="/wiki/Medical_device" title="Medical device">medical device</a>. This is especially important in terms of <a href="/wiki/Mechanical_properties_of_biomaterials" title="Mechanical properties of biomaterials">mechanical properties</a> which govern the way that a given biomaterial behaves. One of the most relevant material parameters is the <a href="/wiki/Young%27s_modulus" title="Young's modulus">Young's Modulus, <i>E</i></a>, which describes a material's <a href="/wiki/Stress%E2%80%93strain_curve" title="Stress–strain curve">elastic response to stresses</a>. The Young's Moduli of the tissue and the device that is being coupled to it must closely match for optimal compatibility between device and body, whether the device is <a href="/wiki/Implant_(medicine)" title="Implant (medicine)">implanted</a> or mounted externally. Matching the elastic modulus makes it possible to limit movement and <a href="/wiki/Delamination" title="Delamination">delamination</a> at the <a href="/wiki/Biointerface" title="Biointerface">biointerface</a> between implant and tissue as well as avoiding <a href="/wiki/Stress_concentration" title="Stress concentration">stress concentration</a> that can lead to <a href="/wiki/Mechanical_failure" class="mw-redirect" title="Mechanical failure">mechanical failure</a>. Other important properties are the <a href="/wiki/Tensile_testing" title="Tensile testing">tensile</a> and <a href="/wiki/Compression_(physics)" title="Compression (physics)">compressive</a> strengths which quantify the maximum stresses a material can withstand before breaking and may be used to set <a href="/wiki/Stress_(mechanics)" title="Stress (mechanics)">stress</a> limits that a device may be subject to within or external to the body. Depending on the application, it may be desirable for a biomaterial to have high strength so that it is resistant to failure when subjected to a load, however in other applications it may be beneficial for the material to be low strength. There is a careful balance between strength and stiffness that determines how robust to failure the biomaterial device is. Typically, as the <a href="/wiki/Elasticity_(physics)" title="Elasticity (physics)">elasticity</a> of the biomaterial increases, the <a href="/wiki/Ultimate_tensile_strength" title="Ultimate tensile strength">ultimate tensile strength</a> will decrease and vice versa. One application where a high-strength material is undesired is in <a href="/wiki/Microelectrode_array" title="Microelectrode array">neural probes</a>; if a high-strength material is used in these applications the tissue will always <a href="/wiki/Failure_cause" title="Failure cause">fail</a> before the device does (under applied <a href="/wiki/Mechanical_load" title="Mechanical load">load</a>) because the Young's Modulus of the <a href="/wiki/Dura_mater" title="Dura mater">dura mater</a> and <a href="/wiki/Cerebrum" title="Cerebrum">cerebral</a> tissue is on the order of 500 <a href="/wiki/Pascal_(unit)" title="Pascal (unit)">Pa</a>. When this happens, irreversible damage to the brain can occur, thus the biomaterial must have an elastic modulus less than or equal to brain tissue and a low tensile strength if an applied load is expected.<sup id="cite_ref-Saini2015_49-0" class="reference"><a href="#cite_note-Saini2015-49"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-LacourCourtine2016_50-0" class="reference"><a href="#cite_note-LacourCourtine2016-50"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </p><p>For implanted biomaterials that may experience <a href="/wiki/Temperature" title="Temperature">temperature</a> <a href="/wiki/Thermal_fluctuations" title="Thermal fluctuations">fluctuations</a>, e.g., <a href="/wiki/Dental_implant" title="Dental implant">dental implants</a>, <a href="/wiki/Ductility" title="Ductility">ductility</a> is important. The material must be ductile for a similar reason that the tensile strength cannot be too high, ductility allows the material to bend without <a href="/wiki/Fracture_mechanics" title="Fracture mechanics">fracture</a> and also prevents the <a href="/wiki/Stress_concentration" title="Stress concentration">concentration of stresses</a> in the tissue when the temperature changes. The material property of <a href="/wiki/Toughness" title="Toughness">toughness</a> is also important for dental implants as well as any other rigid, load-bearing <a href="/wiki/Implant_(medicine)" title="Implant (medicine)">implant</a> such as a <a href="/wiki/Hip_replacement" title="Hip replacement">replacement hip joint</a>. Toughness describes the material's ability to <a href="/wiki/Deformation_(mechanics)" class="mw-redirect" title="Deformation (mechanics)">deform</a> under applied stress without <a href="/wiki/Fracture" title="Fracture">fracturing</a> and having a high toughness allows biomaterial implants to last longer within the body, especially when subjected to large stress or <a href="/wiki/Cyclic_stress" title="Cyclic stress">cyclically loaded stresses</a>, like the stresses applied to a <a href="/wiki/Hip" title="Hip">hip joint</a> during running.<sup id="cite_ref-Saini2015_49-1" class="reference"><a href="#cite_note-Saini2015-49"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> </p><p>For medical devices that are implanted or attached to the skin, another important property requiring consideration is the <a href="/wiki/Flexural_rigidity" title="Flexural rigidity">flexural rigidity, <i>D</i></a>. <a href="/wiki/Flexural_rigidity" title="Flexural rigidity">Flexural rigidity</a> will determine how well the device surface can maintain <a href="https://en.wiktionary.org/wiki/Special:Search/conformal" class="extiw" title="wikt:Special:Search/conformal">conformal</a> contact with the <a href="/wiki/Tissue_(biology)" title="Tissue (biology)">tissue</a> surface, which is especially important for devices that are measuring tissue motion (<a href="/wiki/Deformation_(mechanics)" class="mw-redirect" title="Deformation (mechanics)">strain</a>), <a href="/wiki/Electrophysiology" title="Electrophysiology">electrical signals</a> (<a href="/wiki/Impedance_cardiography" title="Impedance cardiography">impedance</a>), or are designed to stick to the skin without <a href="/wiki/Delamination" title="Delamination">delaminating</a>, as in epidermal electronics. Since flexural rigidity depends on the thickness of the material, <i>h</i>, to the third power (<i>h</i><sup>3</sup>), it is very important that a biomaterial can be formed into <a href="/wiki/Thin_film" title="Thin film">thin layers</a> in the previously mentioned applications where <a href="/wiki/Conformal_geometry" title="Conformal geometry">conformality</a> is paramount.<sup id="cite_ref-ChoiLee2016_51-0" class="reference"><a href="#cite_note-ChoiLee2016-51"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=18" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The molecular composition of a biomaterial determines the physical and chemical properties of a biomaterial. These compositions create complex structures that allow the biomaterial to function, and therefore are necessary to define and understand in order to develop a biomaterial. biomaterials can be designed to replicate natural organisms, a process known as <a href="/wiki/Biomimetics" title="Biomimetics">biomimetics</a>.<sup id="cite_ref-52" class="reference"><a href="#cite_note-52"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> The structure of a biomaterial can be observed at different at different levels to better understand a materials properties and function. </p> <div class="mw-heading mw-heading3"><h3 id="Atomic_structure">Atomic structure</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=19" title="Edit section: Atomic structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Atomic_structure_of_Lithium-7.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Atomic_structure_of_Lithium-7.svg/170px-Atomic_structure_of_Lithium-7.svg.png" decoding="async" width="170" height="193" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Atomic_structure_of_Lithium-7.svg/255px-Atomic_structure_of_Lithium-7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/15/Atomic_structure_of_Lithium-7.svg/340px-Atomic_structure_of_Lithium-7.svg.png 2x" data-file-width="512" data-file-height="582" /></a><figcaption><a href="/wiki/Rutherford_model" title="Rutherford model">Rutherford model</a> of lithium-7's atomic structure</figcaption></figure> <p>The arrangement of <a href="/wiki/Atom" title="Atom">atoms</a> and <a href="/wiki/Ion" title="Ion">ions</a> within a material is one of the most important structural properties of a biomaterial. The <a href="/wiki/Atomic_structure" class="mw-redirect" title="Atomic structure">atomic structure</a> of a material can be viewed at different levels, the <a href="/wiki/Subatomic_scale" title="Subatomic scale">sub atomic</a> level, atomic or <a href="/wiki/Molecule" title="Molecule">molecular</a> level, as well as the <a href="/wiki/Ultrastructure" title="Ultrastructure">ultra-structure</a> created by the atoms and molecules. <a href="/wiki/Intermolecular_force" title="Intermolecular force">Intermolecular forces</a> between the atoms and molecules that compose the material will determine its material and chemical properties.<sup id="cite_ref-53" class="reference"><a href="#cite_note-53"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup> </p><p>The sub atomic level observes the electrical structure of an individual atom to define its interactions with other atoms and molecules. The molecular structure observes the arrangement of atoms within the material. Finally the ultra-structure observes the 3-D structure created from the atomic and molecular structures of the material. The solid-state of a material is characterized by the intramolecular bonds between the atoms and molecules that comprise the material. Types of intramolecular bonds include: <a href="/wiki/Ionic_bonding" title="Ionic bonding">ionic bonds</a>, <a href="/wiki/Covalent_bond" title="Covalent bond">covalent bonds</a>, and <a href="/wiki/Metallic_bonding" title="Metallic bonding">metallic bonds</a>. These bonds will dictate the physical and chemical properties of the material, as well as determine the type of material (<a href="/wiki/Ceramic" title="Ceramic">ceramic</a>, <a href="/wiki/Metal" title="Metal">metal</a>, or <a href="/wiki/Polymer" title="Polymer">polymer</a>). </p> <div class="mw-heading mw-heading3"><h3 id="Microstructure">Microstructure</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=20" title="Edit section: Microstructure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:CNX_Chem_10_06_UnitCell1.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/CNX_Chem_10_06_UnitCell1.png/220px-CNX_Chem_10_06_UnitCell1.png" decoding="async" width="220" height="106" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/CNX_Chem_10_06_UnitCell1.png/330px-CNX_Chem_10_06_UnitCell1.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9a/CNX_Chem_10_06_UnitCell1.png/440px-CNX_Chem_10_06_UnitCell1.png 2x" data-file-width="650" data-file-height="314" /></a><figcaption>A unit cell shows the locations of lattice points repeating in all directions.</figcaption></figure> <p>The <a href="/wiki/Microstructure" title="Microstructure">microstructure</a> of a material refers to the structure of an object, organism, or material as viewed at magnifications exceeding 25 times.<sup id="cite_ref-54" class="reference"><a href="#cite_note-54"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> It is composed of the different phases of form, size, and distribution of grains, pores, precipitates, etc. The majority of solid microstructures are <a href="/wiki/Crystalline" class="mw-redirect" title="Crystalline">crystalline</a>, however some materials such as certain polymers will not crystallize when in the solid state.<sup id="cite_ref-55" class="reference"><a href="#cite_note-55"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Crystalline_structure">Crystalline structure</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=21" title="Edit section: Crystalline structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Crystal_structure" title="Crystal structure">Crystalline structure</a> is the composition of ions, atoms, and molecules that are held together and ordered in a 3D shape. The main difference between a crystalline structure and an <a href="/wiki/Amorphous_solid" title="Amorphous solid">amorphous</a> structure is the order of the components. Crystalline has the highest level of order possible in the material where amorphous structure consists of irregularities in the ordering pattern.<sup id="cite_ref-56" class="reference"><a href="#cite_note-56"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup> One way to describe crystalline structures is through the <a href="/wiki/Crystal_lattice" class="mw-redirect" title="Crystal lattice">crystal lattice</a>, which is a three-dimensional representation of the location of a repeating factor (<a href="/wiki/Unit_cell" title="Unit cell">unit cell</a>) in the structure denoted with <a href="/wiki/Lattice_structure" class="mw-redirect" title="Lattice structure">lattices</a>.<sup id="cite_ref-57" class="reference"><a href="#cite_note-57"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup> There are 14 different configurations of atom arrangement in a crystalline structure, and are all represented under <a href="/wiki/Bravais_lattice" title="Bravais lattice">Bravais lattices</a>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (May 2024)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading4"><h4 id="Defects_of_crystalline_structure">Defects of crystalline structure</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=22" title="Edit section: Defects of crystalline structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Crystallographic_defect" title="Crystallographic defect">Crystallographic defect</a></div> <p>During the formation of a crystalline structure, different impurities, irregularities, and other defects can form. These imperfections can form through deformation of the solid, rapid cooling, or high energy radiation.<sup id="cite_ref-58" class="reference"><a href="#cite_note-58"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> Types of defects include point defects, line defects, as well as edge dislocation. </p> <div class="mw-heading mw-heading3"><h3 id="Macrostructure">Macrostructure</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=23" title="Edit section: Macrostructure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Macrostructure refers to the overall geometric properties that will influence the force at failure, stiffness, bending, stress distribution, and the weight of the material. It requires little to no magnification to reveal the macrostructure of a material. Observing the macrostructure reveals properties such as <a href="https://en.wiktionary.org/wiki/cavity" class="extiw" title="wikt:cavity">cavities</a>, <a href="/wiki/Porosity" title="Porosity">porosity</a>, gas bubbles, <a href="https://en.wiktionary.org/wiki/stratification" class="extiw" title="wikt:stratification">stratification</a>, and <a href="/wiki/Fissure" title="Fissure">fissures</a>.<sup id="cite_ref-59" class="reference"><a href="#cite_note-59"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup> The material's strength and elastic modulus are both independent of the macrostructure. </p> <div class="mw-heading mw-heading2"><h2 id="Natural_biomaterials">Natural biomaterials</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=24" title="Edit section: Natural biomaterials"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Biomaterials can be constructed using only materials sourced from plants and animals in order to alter, replace, or repair human tissue/organs. Use of natural biomaterials were used as early as ancient Egypt, where indigenous people used animal skin as sutures. A more modern example is a hip replacement using ivory material which was first recorded in Germany 1891.<sup id="cite_ref-60" class="reference"><a href="#cite_note-60"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup> </p><p>Valuable criteria for viable natural biomaterials: </p> <ul><li><a href="/wiki/Biodegradable" class="mw-redirect" title="Biodegradable">Biodegradable</a></li> <li><a href="/wiki/Biocompatibility" title="Biocompatibility">Biocompatible</a></li> <li>Able to promote cell attachment and growth</li> <li>Non-toxic</li></ul> <p>Examples of natural biomaterials: </p> <ul><li><a href="/wiki/Alginate" class="mw-redirect" title="Alginate">Alginate</a><sup id="cite_ref-61" class="reference"><a href="#cite_note-61"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Matrigel" title="Matrigel">Matrigel</a></li> <li><a href="/wiki/Fibrin" title="Fibrin">Fibrin</a></li> <li><a href="/wiki/Collagen" title="Collagen">Collagen</a></li> <li>Myocardial tissue engineering<sup id="cite_ref-62" class="reference"><a href="#cite_note-62"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Biopolymers">Biopolymers</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=25" title="Edit section: Biopolymers"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Biopolymer" title="Biopolymer">Biopolymer</a></div> <p>Biopolymers are <a href="/wiki/Polymer" title="Polymer">polymers</a> produced by living organisms. <a href="/wiki/Cellulose" title="Cellulose">Cellulose</a> and <a href="/wiki/Starch" title="Starch">starch</a>, <a href="/wiki/Protein" title="Protein">proteins</a> and <a href="/wiki/Peptide" title="Peptide">peptides</a>, and <a href="/wiki/DNA" title="DNA">DNA</a> and <a href="/wiki/RNA" title="RNA">RNA</a> are all examples of biopolymers, in which the <a href="/wiki/Monomer" title="Monomer">monomeric</a> units, respectively, are <a href="/wiki/Sugar" title="Sugar">sugars</a>, <a href="/wiki/Amino_acid" title="Amino acid">amino acids</a>, and <a href="/wiki/Nucleotide" title="Nucleotide">nucleotides</a>.<sup id="cite_ref-63" class="reference"><a href="#cite_note-63"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup> Cellulose is both the most common biopolymer and the most common organic compound on Earth. About 33% of all plant matter is cellulose.<sup id="cite_ref-64" class="reference"><a href="#cite_note-64"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-65" class="reference"><a href="#cite_note-65"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup> On a similar manner, silk (proteinaceous biopolymer) has garnered tremendous research interest in a myriad of domains including tissue engineering and regenerative medicine, microfluidics, drug delivery.<sup id="cite_ref-66" class="reference"><a href="#cite_note-66"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-67" class="reference"><a href="#cite_note-67"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=26" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Bionics" title="Bionics">Bionics</a></li> <li><a href="/wiki/Hydrogel" title="Hydrogel">Hydrogel</a></li> <li><a href="/wiki/Polymeric_surface" title="Polymeric surface">Polymeric surface</a></li> <li><a href="/wiki/Surface_modification_of_biomaterials_with_proteins" title="Surface modification of biomaterials with proteins">Surface modification of biomaterials with proteins</a></li> <li><a href="/wiki/Synthetic_biodegradable_polymer" title="Synthetic biodegradable polymer">Synthetic biodegradable polymer</a></li> <li><a href="/wiki/Category:Biomaterials" title="Category:Biomaterials">List of biomaterials</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Footnotes">Footnotes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=27" title="Edit section: Footnotes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-lower-alpha"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text">The notion of exploitation includes utility for applications and for fundamental research to understand reciprocal perturbations as well.<sup id="cite_ref-IUPAC_2-1" class="reference"><a href="#cite_note-IUPAC-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text">The definition "non-viable material used in a medical device, intended to interact with biological systems" recommended in ref.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> cannot be extended to the environmental field where people mean "material of natural origin".<sup id="cite_ref-IUPAC_2-2" class="reference"><a href="#cite_note-IUPAC-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text">This general term should not be confused with the terms <i>biopolymer</i> or <i>biomacromolecule</i>. The use of "polymeric biomaterial" is recommended when one deals with <i><a href="/wiki/Polymer" title="Polymer">polymer</a></i> or polymer device of therapeutic or biological interest.<sup id="cite_ref-IUPAC_2-3" class="reference"><a href="#cite_note-IUPAC-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Biomaterial&action=edit&section=28" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239543626"><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-SchmalzBio08-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-SchmalzBio08_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFSchmalz,_G.Arenholdt-Bindslev,_D.2008" class="citation book cs1">Schmalz, G.; Arenholdt-Bindslev, D. (2008). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=mrreTHuo54wC&pg=PA1">"Chapter 1: Basic Aspects"</a>. <i>Biocompatibility of Dental Materials</i>. Berlin: Springer-Verlag. pp. <span class="nowrap">1–</span>12. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9783540777823" title="Special:BookSources/9783540777823"><bdi>9783540777823</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20171209201948/https://books.google.com/books?id=mrreTHuo54wC&pg=PA1">Archived</a> from the original on 9 December 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">29 February</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Chapter+1%3A+Basic+Aspects&rft.btitle=Biocompatibility+of+Dental+Materials&rft.place=Berlin&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1-%3C%2Fspan%3E12&rft.pub=Springer-Verlag&rft.date=2008&rft.isbn=9783540777823&rft.au=Schmalz%2C+G.&rft.au=Arenholdt-Bindslev%2C+D.&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DmrreTHuo54wC%26pg%3DPA1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-IUPAC-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-IUPAC_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-IUPAC_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-IUPAC_2-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-IUPAC_2-3"><sup><i><b>d</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVertDoiHellwichHess2012" class="citation journal cs1">Vert, M.; Doi, Y.; Hellwich, K. H.; Hess, M.; Hodge, P.; Kubisa, P.; Rinaudo, M.; Schué, F. O. (2012). <a rel="nofollow" class="external text" href="https://doi.org/10.1351%2FPAC-REC-10-12-04">"Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)"</a>. <i>Pure and Applied Chemistry</i>. <b>84</b> (2): 377. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1351%2FPAC-REC-10-12-04">10.1351/PAC-REC-10-12-04</a></span>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:98107080">98107080</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pure+and+Applied+Chemistry&rft.atitle=Terminology+for+biorelated+polymers+and+applications+%28IUPAC+Recommendations+2012%29&rft.volume=84&rft.issue=2&rft.pages=377&rft.date=2012&rft_id=info%3Adoi%2F10.1351%2FPAC-REC-10-12-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A98107080%23id-name%3DS2CID&rft.aulast=Vert&rft.aufirst=M.&rft.au=Doi%2C+Y.&rft.au=Hellwich%2C+K.+H.&rft.au=Hess%2C+M.&rft.au=Hodge%2C+P.&rft.au=Kubisa%2C+P.&rft.au=Rinaudo%2C+M.&rft.au=Schu%C3%A9%2C+F.+O.&rft_id=https%3A%2F%2Fdoi.org%2F10.1351%252FPAC-REC-10-12-04&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWilliams,_D._F.2004" class="citation book cs1">Williams, D. F., ed. (2004). <i>Definitions in Biomaterials, Proceedings of a Consensus Conference of the European Society for Biomaterials</i>. Amsterdam: Elsevier.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Definitions+in+Biomaterials%2C+Proceedings+of+a+Consensus+Conference+of+the+European+Society+for+Biomaterials&rft.place=Amsterdam&rft.pub=Elsevier&rft.date=2004&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCaoHench1996" class="citation journal cs1">Cao, Wanpeng; Hench, Larry (1996). "Bioactive Materials". <i>Ceramics International</i>. <b>22</b> (6): <span class="nowrap">493–</span>507. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0272-8842%2895%2900126-3">10.1016/0272-8842(95)00126-3</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Ceramics+International&rft.atitle=Bioactive+Materials&rft.volume=22&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E493-%3C%2Fspan%3E507&rft.date=1996&rft_id=info%3Adoi%2F10.1016%2F0272-8842%2895%2900126-3&rft.aulast=Cao&rft.aufirst=Wanpeng&rft.au=Hench%2C+Larry&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-SDHA-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-SDHA_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhu2018" class="citation journal cs1">Zhu, H.; et al. (2018). "Nanostructural insights into the dissolution behavior of Sr-doped hydroxyapatite". <i>Journal of the European Ceramic Society</i>. <b>38</b> (16): <span class="nowrap">5554–</span>5562. <a href="/wiki/ArXiv_(identifier)" class="mw-redirect" title="ArXiv (identifier)">arXiv</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://arxiv.org/abs/1910.10610">1910.10610</a></span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jeurceramsoc.2018.07.056">10.1016/j.jeurceramsoc.2018.07.056</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:105932012">105932012</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+the+European+Ceramic+Society&rft.atitle=Nanostructural+insights+into+the+dissolution+behavior+of+Sr-doped+hydroxyapatite&rft.volume=38&rft.issue=16&rft.pages=%3Cspan+class%3D%22nowrap%22%3E5554-%3C%2Fspan%3E5562&rft.date=2018&rft_id=info%3Aarxiv%2F1910.10610&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A105932012%23id-name%3DS2CID&rft_id=info%3Adoi%2F10.1016%2Fj.jeurceramsoc.2018.07.056&rft.aulast=Zhu&rft.aufirst=H.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFerreiraMilanoRangelPeppelenbosch2020" class="citation journal cs1">Ferreira, Marcel; Milano, Renato; Rangel, Elidiano; Peppelenbosch, Maikel; Zambuzzi, Willian (2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578266">"OsteoBLAST: Computational Routine of Global Molecular Analysis Applied to Biomaterials Development"</a>. <i>Frontiers in Bioengineering and Biotechnology</i>. <b>8</b>: 565901. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffbioe.2020.565901">10.3389/fbioe.2020.565901</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578266">7578266</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/33117780">33117780</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Frontiers+in+Bioengineering+and+Biotechnology&rft.atitle=OsteoBLAST%3A+Computational+Routine+of+Global+Molecular+Analysis+Applied+to+Biomaterials+Development&rft.volume=8&rft.pages=565901&rft.date=2020&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7578266%23id-name%3DPMC&rft_id=info%3Apmid%2F33117780&rft_id=info%3Adoi%2F10.3389%2Ffbioe.2020.565901&rft.aulast=Ferreira&rft.aufirst=Marcel&rft.au=Milano%2C+Renato&rft.au=Rangel%2C+Elidiano&rft.au=Peppelenbosch%2C+Maikel&rft.au=Zambuzzi%2C+Willian&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7578266&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWhitesidesMathiasSeto1991" class="citation journal cs1">Whitesides, G.; Mathias, J.; Seto, C. (1991). "Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures". <i>Science</i>. <b>254</b> (5036): <span class="nowrap">1312–</span>9. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1991Sci...254.1312W">1991Sci...254.1312W</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.1962191">10.1126/science.1962191</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1962191">1962191</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Molecular+self-assembly+and+nanochemistry%3A+A+chemical+strategy+for+the+synthesis+of+nanostructures&rft.volume=254&rft.issue=5036&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1312-%3C%2Fspan%3E9&rft.date=1991&rft_id=info%3Apmid%2F1962191&rft_id=info%3Adoi%2F10.1126%2Fscience.1962191&rft_id=info%3Abibcode%2F1991Sci...254.1312W&rft.aulast=Whitesides&rft.aufirst=G.&rft.au=Mathias%2C+J.&rft.au=Seto%2C+C.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDabbsAksay2000" class="citation journal cs1">Dabbs, D. M.; Aksay, I. A. (2000). "Self-Assembledceramicsproduced Bycomplex-Fluidtemplation". <i>Annual Review of Physical Chemistry</i>. <b>51</b>: <span class="nowrap">601–</span>22. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2000ARPC...51..601D">2000ARPC...51..601D</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev.physchem.51.1.601">10.1146/annurev.physchem.51.1.601</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11031294">11031294</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annual+Review+of+Physical+Chemistry&rft.atitle=Self-Assembledceramicsproduced+Bycomplex-Fluidtemplation&rft.volume=51&rft.pages=%3Cspan+class%3D%22nowrap%22%3E601-%3C%2Fspan%3E22&rft.date=2000&rft_id=info%3Apmid%2F11031294&rft_id=info%3Adoi%2F10.1146%2Fannurev.physchem.51.1.601&rft_id=info%3Abibcode%2F2000ARPC...51..601D&rft.aulast=Dabbs&rft.aufirst=D.+M.&rft.au=Aksay%2C+I.+A.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFArigaHillLeeVinu2008" class="citation journal cs1">Ariga, K.; Hill, J. P.; Lee, M. V.; Vinu, A.; Charvet, R.; Acharya, S. (2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099804">"Challenges and breakthroughs in recent research on self-assembly"</a>. <i>Science and Technology of Advanced Materials</i>. <b>9</b> (1): 014109. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2008STAdM...9a4109A">2008STAdM...9a4109A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1088%2F1468-6996%2F9%2F1%2F014109">10.1088/1468-6996/9/1/014109</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099804">5099804</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27877935">27877935</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science+and+Technology+of+Advanced+Materials&rft.atitle=Challenges+and+breakthroughs+in+recent+research+on+self-assembly&rft.volume=9&rft.issue=1&rft.pages=014109&rft.date=2008&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5099804%23id-name%3DPMC&rft_id=info%3Apmid%2F27877935&rft_id=info%3Adoi%2F10.1088%2F1468-6996%2F9%2F1%2F014109&rft_id=info%3Abibcode%2F2008STAdM...9a4109A&rft.aulast=Ariga&rft.aufirst=K.&rft.au=Hill%2C+J.+P.&rft.au=Lee%2C+M.+V.&rft.au=Vinu%2C+A.&rft.au=Charvet%2C+R.&rft.au=Acharya%2C+S.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5099804&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNepalKangAdstedtKanhaiya2022" class="citation journal cs1">Nepal, Dhriti; Kang, Saewon; Adstedt, Katarina M.; Kanhaiya, Krishan; Bockstaller, Michael R.; Brinson, L. Catherine; Buehler, Markus J.; Coveney, Peter V.; Dayal, Kaushik; El-Awady, Jaafar A.; Henderson, Luke C.; <a href="/wiki/David_L._Kaplan_(engineer)" title="David L. Kaplan (engineer)">Kaplan, David L.</a>; Keten, Sinan; Kotov, Nicholas A.; Schatz, George C. (2022-11-28). <a rel="nofollow" class="external text" href="https://discovery.ucl.ac.uk/10179540/1/main_article_v265_reduced_file_size.pdf">"Hierarchically structured bioinspired nanocomposites"</a> <span class="cs1-format">(PDF)</span>. <i>Nature Materials</i>. <b>22</b> (1): <span class="nowrap">18–</span>35. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fs41563-022-01384-1">10.1038/s41563-022-01384-1</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1476-1122">1476-1122</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/36446962">36446962</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:254094123">254094123</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Materials&rft.atitle=Hierarchically+structured+bioinspired+nanocomposites&rft.volume=22&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E18-%3C%2Fspan%3E35&rft.date=2022-11-28&rft.issn=1476-1122&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A254094123%23id-name%3DS2CID&rft_id=info%3Apmid%2F36446962&rft_id=info%3Adoi%2F10.1038%2Fs41563-022-01384-1&rft.aulast=Nepal&rft.aufirst=Dhriti&rft.au=Kang%2C+Saewon&rft.au=Adstedt%2C+Katarina+M.&rft.au=Kanhaiya%2C+Krishan&rft.au=Bockstaller%2C+Michael+R.&rft.au=Brinson%2C+L.+Catherine&rft.au=Buehler%2C+Markus+J.&rft.au=Coveney%2C+Peter+V.&rft.au=Dayal%2C+Kaushik&rft.au=El-Awady%2C+Jaafar+A.&rft.au=Henderson%2C+Luke+C.&rft.au=Kaplan%2C+David+L.&rft.au=Keten%2C+Sinan&rft.au=Kotov%2C+Nicholas+A.&rft.au=Schatz%2C+George+C.&rft_id=https%3A%2F%2Fdiscovery.ucl.ac.uk%2F10179540%2F1%2Fmain_article_v265_reduced_file_size.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStroud2006" class="citation journal cs1">Stroud, R. M. (2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222831">"<i>Present at the flood: How structural biology came about</i>, by Richard E. Dickerson"</a>. <i>Protein Science</i>. <b>16</b> (1): <span class="nowrap">135–</span>136. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1110%2Fps.062627807">10.1110/ps.062627807</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222831">2222831</a></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Present+at+the+flood%3A+How+structural+biology+came+about%2C+by+Richard+E.+Dickerson&rft.volume=16&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E135-%3C%2Fspan%3E136&rft.date=2006&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2222831%23id-name%3DPMC&rft_id=info%3Adoi%2F10.1110%2Fps.062627807&rft.aulast=Stroud&rft.aufirst=R.+M.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2222831&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMeyers,_Marc_A.2014" class="citation book cs1">Meyers, Marc A. (2014-07-31). <i>Biological materials science : biological materials, bioinspired materials, and biomaterials</i>. Chen, Po-Yu. New York. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-107-01045-1" title="Special:BookSources/978-1-107-01045-1"><bdi>978-1-107-01045-1</bdi></a>. <a href="/wiki/OCLC_(identifier)" class="mw-redirect" title="OCLC (identifier)">OCLC</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/oclc/869269337">869269337</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Biological+materials+science+%3A+biological+materials%2C+bioinspired+materials%2C+and+biomaterials&rft.place=New+York&rft.date=2014-07-31&rft_id=info%3Aoclcnum%2F869269337&rft.isbn=978-1-107-01045-1&rft.au=Meyers%2C+Marc+A.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/Template:Cite_book" title="Template:Cite book">cite book</a>}}</code>: CS1 maint: location missing publisher (<a href="/wiki/Category:CS1_maint:_location_missing_publisher" title="Category:CS1 maint: location missing publisher">link</a>)</span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPal2013" class="citation book cs1">Pal, Subrata (2013-08-31). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=U4u9BAAAQBAJ&q=the+hierarchy+of+abalone+shell+begins+at+the+nanolevel%2C+with+an+organic+layer+having+a+thickness+of+20%E2%80%9330+nm.&pg=PA56"><i>Design of Artificial Human Joints & Organs</i></a>. Springer Science & Business Media. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4614-6255-2" title="Special:BookSources/978-1-4614-6255-2"><bdi>978-1-4614-6255-2</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Design+of+Artificial+Human+Joints+%26+Organs&rft.pub=Springer+Science+%26+Business+Media&rft.date=2013-08-31&rft.isbn=978-1-4614-6255-2&rft.aulast=Pal&rft.aufirst=Subrata&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DU4u9BAAAQBAJ%26q%3Dthe%2Bhierarchy%2Bof%2Babalone%2Bshell%2Bbegins%2Bat%2Bthe%2Bnanolevel%252C%2Bwith%2Ban%2Borganic%2Blayer%2Bhaving%2Ba%2Bthickness%2Bof%2B20%25E2%2580%259330%2Bnm.%26pg%3DPA56&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFIbrahimEsfahaniPoorganjiDean2017" class="citation journal cs1">Ibrahim, H.; Esfahani, S. N.; Poorganji, B.; Dean, D.; Elahinia, M. (January 2017). <a rel="nofollow" class="external text" href="https://zenodo.org/record/996947">"Resorbable bone fixation alloys, forming, and post-fabrication treatments"</a>. <i>Materials Science and Engineering: C</i>. <b>70</b> (1): <span class="nowrap">870–</span>888. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.msec.2016.09.069">10.1016/j.msec.2016.09.069</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27770965">27770965</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Materials+Science+and+Engineering%3A+C&rft.atitle=Resorbable+bone+fixation+alloys%2C+forming%2C+and+post-fabrication+treatments&rft.volume=70&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E870-%3C%2Fspan%3E888&rft.date=2017-01&rft_id=info%3Adoi%2F10.1016%2Fj.msec.2016.09.069&rft_id=info%3Apmid%2F27770965&rft.aulast=Ibrahim&rft.aufirst=H.&rft.au=Esfahani%2C+S.+N.&rft.au=Poorganji%2C+B.&rft.au=Dean%2C+D.&rft.au=Elahinia%2C+M.&rft_id=https%3A%2F%2Fzenodo.org%2Frecord%2F996947&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPillaiSharma2010" class="citation journal cs1">Pillai, C. K. S.; Sharma, C. P. (2010). "Review Paper: Absorbable Polymeric Surgical Sutures: Chemistry, Production, Properties, Biodegradability, and Performance". <i>Journal of Biomaterials Applications</i>. <b>25</b> (4): <span class="nowrap">291–</span>366. <a href="/wiki/CiteSeerX_(identifier)" class="mw-redirect" title="CiteSeerX (identifier)">CiteSeerX</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1013.5873">10.1.1.1013.5873</a></span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F0885328210384890">10.1177/0885328210384890</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20971780">20971780</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:20278355">20278355</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Biomaterials+Applications&rft.atitle=Review+Paper%3A+Absorbable+Polymeric+Surgical+Sutures%3A+Chemistry%2C+Production%2C+Properties%2C+Biodegradability%2C+and+Performance&rft.volume=25&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E291-%3C%2Fspan%3E366&rft.date=2010&rft_id=https%3A%2F%2Fciteseerx.ist.psu.edu%2Fviewdoc%2Fsummary%3Fdoi%3D10.1.1.1013.5873%23id-name%3DCiteSeerX&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A20278355%23id-name%3DS2CID&rft_id=info%3Apmid%2F20971780&rft_id=info%3Adoi%2F10.1177%2F0885328210384890&rft.aulast=Pillai&rft.aufirst=C.+K.+S.&rft.au=Sharma%2C+C.+P.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWarisAshammakhiKaarelaRaatikainen2004" class="citation journal cs1">Waris, E; Ashammakhi, N; Kaarela, O; Raatikainen, T; Vasenius, J (December 2004). "Use of bioabsorbable osteofixation devices in the hand". <i>Journal of Hand Surgery (Edinburgh, Scotland)</i>. <b>29</b> (6): <span class="nowrap">590–</span>8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jhsb.2004.02.005">10.1016/j.jhsb.2004.02.005</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15542222">15542222</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:24385943">24385943</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Hand+Surgery+%28Edinburgh%2C+Scotland%29&rft.atitle=Use+of+bioabsorbable+osteofixation+devices+in+the+hand.&rft.volume=29&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E590-%3C%2Fspan%3E8&rft.date=2004-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A24385943%23id-name%3DS2CID&rft_id=info%3Apmid%2F15542222&rft_id=info%3Adoi%2F10.1016%2Fj.jhsb.2004.02.005&rft.aulast=Waris&rft.aufirst=E&rft.au=Ashammakhi%2C+N&rft.au=Kaarela%2C+O&rft.au=Raatikainen%2C+T&rft.au=Vasenius%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDeasisLapinGitelisUjiki2015" class="citation journal cs1">Deasis, F. J.; Lapin, B; Gitelis, M. E.; Ujiki, M. B. (2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524825">"Current state of laparoscopic parastomal hernia repair: A meta-analysis"</a>. <i>World Journal of Gastroenterology</i>. <b>21</b> (28): <span class="nowrap">8670–</span>7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3748%2Fwjg.v21.i28.8670">10.3748/wjg.v21.i28.8670</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524825">4524825</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26229409">26229409</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=World+Journal+of+Gastroenterology&rft.atitle=Current+state+of+laparoscopic+parastomal+hernia+repair%3A+A+meta-analysis&rft.volume=21&rft.issue=28&rft.pages=%3Cspan+class%3D%22nowrap%22%3E8670-%3C%2Fspan%3E7&rft.date=2015&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4524825%23id-name%3DPMC&rft_id=info%3Apmid%2F26229409&rft_id=info%3Adoi%2F10.3748%2Fwjg.v21.i28.8670&rft.aulast=Deasis&rft.aufirst=F.+J.&rft.au=Lapin%2C+B&rft.au=Gitelis%2C+M.+E.&rft.au=Ujiki%2C+M.+B.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4524825&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-21">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBanyardBourgeoisWidgerowEvans2015" class="citation journal cs1">Banyard, D. A.; Bourgeois, J. M.; Widgerow, A. D.; Evans, G. R. (2015). "Regenerative biomaterials: A review". <i>Plastic and Reconstructive Surgery</i>. <b>135</b> (6): <span class="nowrap">1740–</span>8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FPRS.0000000000001272">10.1097/PRS.0000000000001272</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26017603">26017603</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:33728690">33728690</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Plastic+and+Reconstructive+Surgery&rft.atitle=Regenerative+biomaterials%3A+A+review&rft.volume=135&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1740-%3C%2Fspan%3E8&rft.date=2015&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A33728690%23id-name%3DS2CID&rft_id=info%3Apmid%2F26017603&rft_id=info%3Adoi%2F10.1097%2FPRS.0000000000001272&rft.aulast=Banyard&rft.aufirst=D.+A.&rft.au=Bourgeois%2C+J.+M.&rft.au=Widgerow%2C+A.+D.&rft.au=Evans%2C+G.+R.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-Meyers08-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-Meyers08_22-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMeyersChenLinSeki2008" class="citation journal cs1">Meyers, M. A.; Chen, P. Y.; Lin, A. Y. M.; Seki, Y. (2008). "Biological materials: Structure and mechanical properties". <i>Progress in Materials Science</i>. <b>53</b>: <span class="nowrap">1–</span>206. <a href="/wiki/CiteSeerX_(identifier)" class="mw-redirect" title="CiteSeerX (identifier)">CiteSeerX</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.466.3753">10.1.1.466.3753</a></span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pmatsci.2007.05.002">10.1016/j.pmatsci.2007.05.002</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Progress+in+Materials+Science&rft.atitle=Biological+materials%3A+Structure+and+mechanical+properties&rft.volume=53&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1-%3C%2Fspan%3E206&rft.date=2008&rft_id=https%3A%2F%2Fciteseerx.ist.psu.edu%2Fviewdoc%2Fsummary%3Fdoi%3D10.1.1.466.3753%23id-name%3DCiteSeerX&rft_id=info%3Adoi%2F10.1016%2Fj.pmatsci.2007.05.002&rft.aulast=Meyers&rft.aufirst=M.+A.&rft.au=Chen%2C+P.+Y.&rft.au=Lin%2C+A.+Y.+M.&rft.au=Seki%2C+Y.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-Espinosa09-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-Espinosa09_23-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEspinosaRimBarthelatBuehler2009" class="citation journal cs1">Espinosa, H. D.; Rim, J. E.; Barthelat, F.; Buehler, M. J. (2009). "Merger of structure and material in nacre and bone – Perspectives on de novo biomimetic materials". <i>Progress in Materials Science</i>. <b>54</b> (8): <span class="nowrap">1059–</span>1100. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pmatsci.2009.05.001">10.1016/j.pmatsci.2009.05.001</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Progress+in+Materials+Science&rft.atitle=Merger+of+structure+and+material+in+nacre+and+bone+%E2%80%93+Perspectives+on+de+novo+biomimetic+materials&rft.volume=54&rft.issue=8&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1059-%3C%2Fspan%3E1100&rft.date=2009&rft_id=info%3Adoi%2F10.1016%2Fj.pmatsci.2009.05.001&rft.aulast=Espinosa&rft.aufirst=H.+D.&rft.au=Rim%2C+J.+E.&rft.au=Barthelat%2C+F.&rft.au=Buehler%2C+M.+J.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-24">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhaoYangCooperKhurshid2021" class="citation journal cs1">Zhao, Rusin; Yang, Ruijia; Cooper, Paul R.; Khurshid, Zohaib; Shavandi, Amin; Ratnayake, Jithendra (2021-05-18). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158510">"Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments"</a>. <i>Molecules</i>. <b>26</b> (10): 3007. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3390%2Fmolecules26103007">10.3390/molecules26103007</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1420-3049">1420-3049</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158510">8158510</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34070157">34070157</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecules&rft.atitle=Bone+Grafts+and+Substitutes+in+Dentistry%3A+A+Review+of+Current+Trends+and+Developments&rft.volume=26&rft.issue=10&rft.pages=3007&rft.date=2021-05-18&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8158510%23id-name%3DPMC&rft.issn=1420-3049&rft_id=info%3Apmid%2F34070157&rft_id=info%3Adoi%2F10.3390%2Fmolecules26103007&rft.aulast=Zhao&rft.aufirst=Rusin&rft.au=Yang%2C+Ruijia&rft.au=Cooper%2C+Paul+R.&rft.au=Khurshid%2C+Zohaib&rft.au=Shavandi%2C+Amin&rft.au=Ratnayake%2C+Jithendra&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8158510&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-25">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFThomasPuleoAl-Sabbagh2005" class="citation journal cs1">Thomas, Mark V.; Puleo, David A.; Al-Sabbagh, Mohanad (2005). <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16393128/">"Calcium sulfate: a review"</a>. <i>Journal of Long-Term Effects of Medical Implants</i>. <b>15</b> (6): <span class="nowrap">599–</span>607. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1615%2Fjlongtermeffmedimplants.v15.i6.30">10.1615/jlongtermeffmedimplants.v15.i6.30</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1050-6934">1050-6934</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16393128">16393128</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Long-Term+Effects+of+Medical+Implants&rft.atitle=Calcium+sulfate%3A+a+review&rft.volume=15&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E599-%3C%2Fspan%3E607&rft.date=2005&rft.issn=1050-6934&rft_id=info%3Apmid%2F16393128&rft_id=info%3Adoi%2F10.1615%2Fjlongtermeffmedimplants.v15.i6.30&rft.aulast=Thomas&rft.aufirst=Mark+V.&rft.au=Puleo%2C+David+A.&rft.au=Al-Sabbagh%2C+Mohanad&rft_id=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F16393128%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-Chemistry_Textbook-26"><span class="mw-cite-backlink">^ <a href="#cite_ref-Chemistry_Textbook_26-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Chemistry_Textbook_26-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBrownLeMayBursten2000" class="citation book cs1">Brown, Theodore L.; LeMay, H. Eugene, Jr.; Bursten, Bruce E. (2000). "12.3 Biomaterials". <span class="id-lock-limited" title="Free access subject to limited trial, subscription normally required"><a rel="nofollow" class="external text" href="https://archive.org/details/chemistrycentral00brow_5/page/451"><i>Chemistry: The Central Science</i></a></span> (Annotated Instructor's 8th ed.). Prentice-Hall, Inc. p. <a rel="nofollow" class="external text" href="https://archive.org/details/chemistrycentral00brow_5/page/452">452</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-13-084090-5" title="Special:BookSources/978-0-13-084090-5"><bdi>978-0-13-084090-5</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=12.3+Biomaterials&rft.btitle=Chemistry%3A+The+Central+Science&rft.pages=452&rft.edition=Annotated+Instructor%27s+8th&rft.pub=Prentice-Hall%2C+Inc&rft.date=2000&rft.isbn=978-0-13-084090-5&rft.aulast=Brown&rft.aufirst=Theodore+L.&rft.au=LeMay%2C+H.+Eugene%2C+Jr.&rft.au=Bursten%2C+Bruce+E.&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fchemistrycentral00brow_5%2Fpage%2F451&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span><span class="cs1-maint citation-comment"><code class="cs1-code">{{<a href="/wiki/Template:Cite_book" title="Template:Cite book">cite book</a>}}</code>: CS1 maint: multiple names: authors list (<a href="/wiki/Category:CS1_maint:_multiple_names:_authors_list" title="Category:CS1 maint: multiple names: authors list">link</a>)</span></span> </li> <li id="cite_note-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-27">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1">"Chapter 4: Biomaterials: Basic principles". <i>An Introduction to Biomaterials Science and Engineering</i>. WORLD SCIENTIFIC. May 2021. pp. <span class="nowrap">82–</span>93. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1142%2F9789811228186_0004">10.1142/9789811228186_0004</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-981-12-2817-9" title="Special:BookSources/978-981-12-2817-9"><bdi>978-981-12-2817-9</bdi></a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:240851982">240851982</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Chapter+4%3A+Biomaterials%3A+Basic+principles&rft.btitle=An+Introduction+to+Biomaterials+Science+and+Engineering&rft.pages=%3Cspan+class%3D%22nowrap%22%3E82-%3C%2Fspan%3E93&rft.pub=WORLD+SCIENTIFIC&rft.date=2021-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A240851982%23id-name%3DS2CID&rft_id=info%3Adoi%2F10.1142%2F9789811228186_0004&rft.isbn=978-981-12-2817-9&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-:0-28"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_28-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_28-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBadylak2015" class="citation book cs1">Badylak, Stephen F. (2015-05-08). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=-tucBAAAQBAJ&pg=PP1"><i>Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection</i></a>. Academic Press. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-12-800500-2" title="Special:BookSources/978-0-12-800500-2"><bdi>978-0-12-800500-2</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Host+Response+to+Biomaterials%3A+The+Impact+of+Host+Response+on+Biomaterial+Selection&rft.pub=Academic+Press&rft.date=2015-05-08&rft.isbn=978-0-12-800500-2&rft.aulast=Badylak&rft.aufirst=Stephen+F.&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3D-tucBAAAQBAJ%26pg%3DPP1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-29">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWilliams2008" class="citation journal cs1">Williams, David F. (2008-07-01). "On the mechanisms of biocompatibility". <i>Biomaterials</i>. <b>29</b> (20): <span class="nowrap">2941–</span>2953. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.biomaterials.2008.04.023">10.1016/j.biomaterials.2008.04.023</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0142-9612">0142-9612</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18440630">18440630</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=On+the+mechanisms+of+biocompatibility&rft.volume=29&rft.issue=20&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2941-%3C%2Fspan%3E2953&rft.date=2008-07-01&rft.issn=0142-9612&rft_id=info%3Apmid%2F18440630&rft_id=info%3Adoi%2F10.1016%2Fj.biomaterials.2008.04.023&rft.aulast=Williams&rft.aufirst=David+F.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-30">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMorais2010" class="citation journal cs1">Morais, Jacqueline (2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844517">"Biomaterials/Tissue Interactions: Possible Solutions to Overcome Foreign Body Response"</a>. <i>The AAPS Journal</i>. <b>12</b> (2): <span class="nowrap">188–</span>196. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1208%2Fs12248-010-9175-3">10.1208/s12248-010-9175-3</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844517">2844517</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20143194">20143194</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+AAPS+Journal&rft.atitle=Biomaterials%2FTissue+Interactions%3A+Possible+Solutions+to+Overcome+Foreign+Body+Response&rft.volume=12&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E188-%3C%2Fspan%3E196&rft.date=2010&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2844517%23id-name%3DPMC&rft_id=info%3Apmid%2F20143194&rft_id=info%3Adoi%2F10.1208%2Fs12248-010-9175-3&rft.aulast=Morais&rft.aufirst=Jacqueline&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2844517&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-31"><span class="mw-cite-backlink"><b><a href="#cite_ref-31">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://medlineplus.gov/ency/article/002357.htm">"Exudate: MedlinePlus Medical Encyclopedia"</a>. <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a><span class="reference-accessdate">. Retrieved <span class="nowrap">July 11,</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Exudate%3A+MedlinePlus+Medical+Encyclopedia&rft.pub=United+States+National+Library+of+Medicine&rft_id=https%3A%2F%2Fmedlineplus.gov%2Fency%2Farticle%2F002357.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-:1-32"><span class="mw-cite-backlink">^ <a href="#cite_ref-:1_32-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:1_32-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRn2003" class="citation journal cs1">Rn, Mitchell (2003). <a rel="nofollow" class="external text" href="https://cir.nii.ac.jp/crid/1572261550104557056">"Acute and chronic inflammation"</a>. <i>Robbins Basic Pathology</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Robbins+Basic+Pathology&rft.atitle=Acute+and+chronic+inflammation&rft.date=2003&rft.aulast=Rn&rft.aufirst=Mitchell&rft_id=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1572261550104557056&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-33">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJohnston1988" class="citation journal cs1">Johnston, R. B. (1988-03-24). <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3279314/">"Current concepts: immunology. Monocytes and macrophages"</a>. <i>The New England Journal of Medicine</i>. <b>318</b> (12): <span class="nowrap">747–</span>752. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJM198803243181205">10.1056/NEJM198803243181205</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0028-4793">0028-4793</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3279314">3279314</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Current+concepts%3A+immunology.+Monocytes+and+macrophages&rft.volume=318&rft.issue=12&rft.pages=%3Cspan+class%3D%22nowrap%22%3E747-%3C%2Fspan%3E752&rft.date=1988-03-24&rft.issn=0028-4793&rft_id=info%3Apmid%2F3279314&rft_id=info%3Adoi%2F10.1056%2FNEJM198803243181205&rft.aulast=Johnston&rft.aufirst=R.+B.&rft_id=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F3279314%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-34"><span class="mw-cite-backlink"><b><a href="#cite_ref-34">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKovacs1991" class="citation journal cs1">Kovacs, E. J. (January 1991). <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2015044/">"Fibrogenic cytokines: the role of immune mediators in the development of scar tissue"</a>. <i>Immunology Today</i>. <b>12</b> (1): <span class="nowrap">17–</span>23. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0167-5699%2891%2990107-5">10.1016/0167-5699(91)90107-5</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0167-5699">0167-5699</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2015044">2015044</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Immunology+Today&rft.atitle=Fibrogenic+cytokines%3A+the+role+of+immune+mediators+in+the+development+of+scar+tissue&rft.volume=12&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E17-%3C%2Fspan%3E23&rft.date=1991-01&rft.issn=0167-5699&rft_id=info%3Apmid%2F2015044&rft_id=info%3Adoi%2F10.1016%2F0167-5699%2891%2990107-5&rft.aulast=Kovacs&rft.aufirst=E.+J.&rft_id=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F2015044%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-35"><span class="mw-cite-backlink"><b><a href="#cite_ref-35">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSridharanCavanaghCameronKelly2019" class="citation journal cs1">Sridharan, Rukmani; Cavanagh, Brenton; Cameron, Andrew R.; Kelly, Daniel J.; O'Brien, Fergal J. (February 2019). "Material stiffness influences the polarization state, function and migration mode of macrophages". <i>Acta Biomaterialia</i>. <b>89</b>: <span class="nowrap">47–</span>59. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.actbio.2019.02.048">10.1016/j.actbio.2019.02.048</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30826478">30826478</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:73489194">73489194</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Material+stiffness+influences+the+polarization+state%2C+function+and+migration+mode+of+macrophages&rft.volume=89&rft.pages=%3Cspan+class%3D%22nowrap%22%3E47-%3C%2Fspan%3E59&rft.date=2019-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A73489194%23id-name%3DS2CID&rft_id=info%3Apmid%2F30826478&rft_id=info%3Adoi%2F10.1016%2Fj.actbio.2019.02.048&rft.aulast=Sridharan&rft.aufirst=Rukmani&rft.au=Cavanagh%2C+Brenton&rft.au=Cameron%2C+Andrew+R.&rft.au=Kelly%2C+Daniel+J.&rft.au=O%27Brien%2C+Fergal+J.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-36"><span class="mw-cite-backlink"><b><a href="#cite_ref-36">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKammulaMorris2001" class="citation web cs1">Kammula, Raju G.; Morris, Janine M. (May 1, 2001). <a rel="nofollow" class="external text" href="http://www.mddionline.com/article/considerations-biocompatibility-evaluation-medical-devices">"Considerations for the Biocompatibility Evaluation of Medical Devices"</a>. <i>Medical Device & Diagnostic Industry</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Medical+Device+%26+Diagnostic+Industry&rft.atitle=Considerations+for+the+Biocompatibility+Evaluation+of+Medical+Devices&rft.date=2001-05-01&rft.aulast=Kammula&rft.aufirst=Raju+G.&rft.au=Morris%2C+Janine+M.&rft_id=http%3A%2F%2Fwww.mddionline.com%2Farticle%2Fconsiderations-biocompatibility-evaluation-medical-devices&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-VelnarBunc2016-37"><span class="mw-cite-backlink"><b><a href="#cite_ref-VelnarBunc2016_37-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVelnarBuncKlobucarGradisnik2016" class="citation journal cs1">Velnar, Tomaz; Bunc, Gorazd; Klobucar, Robert; Gradisnik, Lidija (2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853000">"Biomaterials and host versus graft response: a short review"</a>. <i>Bosnian Journal of Basic Medical Sciences</i>. <b>16</b> (2): <span class="nowrap">82–</span>90. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.17305%2Fbjbms.2016.525">10.17305/bjbms.2016.525</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1840-4812">1840-4812</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853000">4853000</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26894284">26894284</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bosnian+Journal+of+Basic+Medical+Sciences&rft.atitle=Biomaterials+and+host+versus+graft+response%3A+a+short+review&rft.volume=16&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E82-%3C%2Fspan%3E90&rft.date=2016&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4853000%23id-name%3DPMC&rft.issn=1840-4812&rft_id=info%3Apmid%2F26894284&rft_id=info%3Adoi%2F10.17305%2Fbjbms.2016.525&rft.aulast=Velnar&rft.aufirst=Tomaz&rft.au=Bunc%2C+Gorazd&rft.au=Klobucar%2C+Robert&rft.au=Gradisnik%2C+Lidija&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4853000&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-38"><span class="mw-cite-backlink"><b><a href="#cite_ref-38">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFThomasGrohensNinan2015" class="citation book cs1">Thomas, Sabu; Grohens, Yves; Ninan, Neethu (8 January 2015). <a rel="nofollow" class="external text" href="https://www.sciencedirect.com/book/9780323328890/nanotechnology-applications-for-tissue-engineering"><i>Nanotechnology Applications for Tissue Engineering</i></a>. Elsevier Science. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780323328890" title="Special:BookSources/9780323328890"><bdi>9780323328890</bdi></a><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Nanotechnology+Applications+for+Tissue+Engineering&rft.pub=Elsevier+Science&rft.date=2015-01-08&rft.isbn=9780323328890&rft.aulast=Thomas&rft.aufirst=Sabu&rft.au=Grohens%2C+Yves&rft.au=Ninan%2C+Neethu&rft_id=https%3A%2F%2Fwww.sciencedirect.com%2Fbook%2F9780323328890%2Fnanotechnology-applications-for-tissue-engineering&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-39"><span class="mw-cite-backlink"><b><a href="#cite_ref-39">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGuMooney2016" class="citation journal cs1">Gu, Luo; Mooney, David J (January 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790726">"Biomaterials and emerging anticancer therapeutics: engineering the microenvironment"</a>. <i>Nature Reviews. Cancer</i>. <b>16</b> (1): <span class="nowrap">56–</span>66. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnrc.2015.3">10.1038/nrc.2015.3</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1474-1768">1474-1768</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790726">4790726</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26694936">26694936</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Reviews.+Cancer&rft.atitle=Biomaterials+and+emerging+anticancer+therapeutics%3A+engineering+the+microenvironment&rft.volume=16&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E56-%3C%2Fspan%3E66&rft.date=2016-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4790726%23id-name%3DPMC&rft.issn=1474-1768&rft_id=info%3Apmid%2F26694936&rft_id=info%3Adoi%2F10.1038%2Fnrc.2015.3&rft.aulast=Gu&rft.aufirst=Luo&rft.au=Mooney%2C+David+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4790726&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-40"><span class="mw-cite-backlink"><b><a href="#cite_ref-40">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYangShiJiaHao2020" class="citation journal cs1">Yang, Fan; Shi, Kun; Jia, Yan-peng; Hao, Ying; Peng, Jin-rong; Qian, Zhi-yong (July 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468530">"Advanced biomaterials for cancer immunotherapy"</a>. <i>Acta Pharmacologica Sinica</i>. <b>41</b> (7): <span class="nowrap">911–</span>927. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fs41401-020-0372-z">10.1038/s41401-020-0372-z</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1745-7254">1745-7254</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468530">7468530</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32123302">32123302</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Acta+Pharmacologica+Sinica&rft.atitle=Advanced+biomaterials+for+cancer+immunotherapy&rft.volume=41&rft.issue=7&rft.pages=%3Cspan+class%3D%22nowrap%22%3E911-%3C%2Fspan%3E927&rft.date=2020-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7468530%23id-name%3DPMC&rft.issn=1745-7254&rft_id=info%3Apmid%2F32123302&rft_id=info%3Adoi%2F10.1038%2Fs41401-020-0372-z&rft.aulast=Yang&rft.aufirst=Fan&rft.au=Shi%2C+Kun&rft.au=Jia%2C+Yan-peng&rft.au=Hao%2C+Ying&rft.au=Peng%2C+Jin-rong&rft.au=Qian%2C+Zhi-yong&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7468530&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-Song_3117–3145-41"><span class="mw-cite-backlink">^ <a href="#cite_ref-Song_3117–3145_41-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Song_3117–3145_41-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSongMurphyLiTing2018" class="citation journal cs1">Song, Richard; Murphy, Maxwell; Li, Chenshuang; Ting, Kang; Soo, Chia; Zheng, Zhong (2018-09-24). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161720">"Current development of biodegradable polymeric materials for biomedical applications"</a>. <i>Drug Design, Development and Therapy</i>. <b>12</b>: <span class="nowrap">3117–</span>3145. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2147%2FDDDT.S165440">10.2147/DDDT.S165440</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1177-8881">1177-8881</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161720">6161720</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30288019">30288019</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Design%2C+Development+and+Therapy&rft.atitle=Current+development+of+biodegradable+polymeric+materials+for+biomedical+applications&rft.volume=12&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3117-%3C%2Fspan%3E3145&rft.date=2018-09-24&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6161720%23id-name%3DPMC&rft.issn=1177-8881&rft_id=info%3Apmid%2F30288019&rft_id=info%3Adoi%2F10.2147%2FDDDT.S165440&rft.aulast=Song&rft.aufirst=Richard&rft.au=Murphy%2C+Maxwell&rft.au=Li%2C+Chenshuang&rft.au=Ting%2C+Kang&rft.au=Soo%2C+Chia&rft.au=Zheng%2C+Zhong&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6161720&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-42"><span class="mw-cite-backlink"><b><a href="#cite_ref-42">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSongMurphyLiTing2018" class="citation journal cs1">Song, Richard; Murphy, Maxwell; Li, Chenshuang; Ting, Kang; Soo, Chia; Zheng, Zhong (2018-09-24). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161720">"Current development of biodegradable polymeric materials for biomedical applications"</a>. <i>Drug Design, Development and Therapy</i>. <b>12</b>: <span class="nowrap">3117–</span>3145. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2147%2FDDDT.S165440">10.2147/DDDT.S165440</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1177-8881">1177-8881</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161720">6161720</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30288019">30288019</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Design%2C+Development+and+Therapy&rft.atitle=Current+development+of+biodegradable+polymeric+materials+for+biomedical+applications&rft.volume=12&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3117-%3C%2Fspan%3E3145&rft.date=2018-09-24&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6161720%23id-name%3DPMC&rft.issn=1177-8881&rft_id=info%3Apmid%2F30288019&rft_id=info%3Adoi%2F10.2147%2FDDDT.S165440&rft.aulast=Song&rft.aufirst=Richard&rft.au=Murphy%2C+Maxwell&rft.au=Li%2C+Chenshuang&rft.au=Ting%2C+Kang&rft.au=Soo%2C+Chia&rft.au=Zheng%2C+Zhong&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6161720&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-43"><span class="mw-cite-backlink"><b><a href="#cite_ref-43">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGadGad-McDonald2015" class="citation book cs1">Gad, Shayne Cox; Gad-McDonald, Samantha (2015-12-01). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=qI_wCgAAQBAJ&q=biocompatibility+testing+regulations&pg=PP1"><i>Biomaterials, Medical Devices, and Combination Products: Biocompatibility Testing and Safety Assessment</i></a>. CRC Press. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4822-4838-8" title="Special:BookSources/978-1-4822-4838-8"><bdi>978-1-4822-4838-8</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Biomaterials%2C+Medical+Devices%2C+and+Combination+Products%3A+Biocompatibility+Testing+and+Safety+Assessment&rft.pub=CRC+Press&rft.date=2015-12-01&rft.isbn=978-1-4822-4838-8&rft.aulast=Gad&rft.aufirst=Shayne+Cox&rft.au=Gad-McDonald%2C+Samantha&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DqI_wCgAAQBAJ%26q%3Dbiocompatibility%2Btesting%2Bregulations%26pg%3DPP1&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-44"><span class="mw-cite-backlink"><b><a href="#cite_ref-44">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.kratos.com/applications/techniques/importance-surfaces-or-why-surface-analysis-important">"what is a surface, why is surface analysis important"</a>. <i>www.kratos.com</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.kratos.com&rft.atitle=what+is+a+surface%2C+why+is+surface+analysis+important&rft_id=https%3A%2F%2Fwww.kratos.com%2Fapplications%2Ftechniques%2Fimportance-surfaces-or-why-surface-analysis-important&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-45"><span class="mw-cite-backlink"><b><a href="#cite_ref-45">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangViney2020" class="citation book cs1">Zhang, Guigen; Viney, Christopher (2020-01-01). <a rel="nofollow" class="external text" href="https://www.sciencedirect.com/science/article/pii/B9780128161371000052">"1.2.3 - Bulk Properties of Materials"</a>. In Wagner, William R.; <a href="/wiki/Shelly_Sakiyama-Elbert" title="Shelly Sakiyama-Elbert">Sakiyama-Elbert, Shelly E.</a>; Zhang, Guigen; Yaszemski, Michael J. (eds.). <i>Biomaterials Science</i> (Fourth ed.). Academic Press. pp. <span class="nowrap">41–</span>51. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-12-816137-1" title="Special:BookSources/978-0-12-816137-1"><bdi>978-0-12-816137-1</bdi></a><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-07-26</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=1.2.3+-+Bulk+Properties+of+Materials&rft.btitle=Biomaterials+Science&rft.pages=%3Cspan+class%3D%22nowrap%22%3E41-%3C%2Fspan%3E51&rft.edition=Fourth&rft.pub=Academic+Press&rft.date=2020-01-01&rft.isbn=978-0-12-816137-1&rft.aulast=Zhang&rft.aufirst=Guigen&rft.au=Viney%2C+Christopher&rft_id=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FB9780128161371000052&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-46"><span class="mw-cite-backlink"><b><a href="#cite_ref-46">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRoachEglinRohdePerry2007" class="citation journal cs1">Roach, Paul; Eglin, David; Rohde, Kirsty; Perry, Carole C. (2007). <a rel="nofollow" class="external text" href="https://www.researchgate.net/publication/6386093">"Modern biomaterials: A review—Bulk properties and implications of surface modifications"</a>. <i>Journal of Materials Science: Materials in Medicine</i>. <b>18</b> (7): <span class="nowrap">1263–</span>1277. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10856-006-0064-3">10.1007/s10856-006-0064-3</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17443395">17443395</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:46254118">46254118</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Materials+Science%3A+Materials+in+Medicine&rft.atitle=Modern+biomaterials%3A+A+review%E2%80%94Bulk+properties+and+implications+of+surface+modifications&rft.volume=18&rft.issue=7&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1263-%3C%2Fspan%3E1277&rft.date=2007&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A46254118%23id-name%3DS2CID&rft_id=info%3Apmid%2F17443395&rft_id=info%3Adoi%2F10.1007%2Fs10856-006-0064-3&rft.aulast=Roach&rft.aufirst=Paul&rft.au=Eglin%2C+David&rft.au=Rohde%2C+Kirsty&rft.au=Perry%2C+Carole+C.&rft_id=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F6386093&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-47"><span class="mw-cite-backlink"><b><a href="#cite_ref-47">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVogler2013" class="citation book cs1">Vogler, Erwin A. (2013). "Chapter 8 - Surface Modification for Biocompatibility". In Lakhtakia, Akhlesh; Martín-Palma, Raúl J. (eds.). <i>Engineered Biomimicry</i>. Boston: Elsevier. pp. <span class="nowrap">189–</span>220. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-12-415995-2" title="Special:BookSources/978-0-12-415995-2"><bdi>978-0-12-415995-2</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Chapter+8+-+Surface+Modification+for+Biocompatibility&rft.btitle=Engineered+Biomimicry&rft.place=Boston&rft.pages=%3Cspan+class%3D%22nowrap%22%3E189-%3C%2Fspan%3E220&rft.pub=Elsevier&rft.date=2013&rft.isbn=978-0-12-415995-2&rft.aulast=Vogler&rft.aufirst=Erwin+A.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-48"><span class="mw-cite-backlink"><b><a href="#cite_ref-48">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.biolinscientific.com/blog/how-surface-roughness-and-wettability-affects-biocompatibility-0">"How surface roughness and wettability affects biocompatibility"</a>. <i>www.biolinscientific.com</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.biolinscientific.com&rft.atitle=How+surface+roughness+and+wettability+affects+biocompatibility&rft_id=https%3A%2F%2Fwww.biolinscientific.com%2Fblog%2Fhow-surface-roughness-and-wettability-affects-biocompatibility-0&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-Saini2015-49"><span class="mw-cite-backlink">^ <a href="#cite_ref-Saini2015_49-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Saini2015_49-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSainiSinghAroraArora2015" class="citation journal cs1">Saini, Monika; Singh, Yashpal; Arora, Pooja; Arora, Vipin; Jain, Krati (January 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295219">"Implant biomaterials: A comprehensive review"</a>. <i>World Journal of Clinical Cases</i>. <b>3</b> (1): <span class="nowrap">52–</span>7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.12998%2Fwjcc.v3.i1.52">10.12998/wjcc.v3.i1.52</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/2307-8960">2307-8960</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295219">4295219</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25610850">25610850</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=World+Journal+of+Clinical+Cases&rft.atitle=Implant+biomaterials%3A+A+comprehensive+review&rft.volume=3&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E52-%3C%2Fspan%3E7&rft.date=2015-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4295219%23id-name%3DPMC&rft.issn=2307-8960&rft_id=info%3Apmid%2F25610850&rft_id=info%3Adoi%2F10.12998%2Fwjcc.v3.i1.52&rft.aulast=Saini&rft.aufirst=Monika&rft.au=Singh%2C+Yashpal&rft.au=Arora%2C+Pooja&rft.au=Arora%2C+Vipin&rft.au=Jain%2C+Krati&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4295219&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-LacourCourtine2016-50"><span class="mw-cite-backlink"><b><a href="#cite_ref-LacourCourtine2016_50-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLacourCourtineGuck2016" class="citation journal cs1">Lacour, Stéphanie P.; Courtine, Grégoire; Guck, Jochen (2016). <a rel="nofollow" class="external text" href="http://infoscience.epfl.ch/record/221479/files/natrevmats201663.pdf">"Materials and technologies for soft implantable neuroprostheses"</a> <span class="cs1-format">(PDF)</span>. <i>Nature Reviews Materials</i>. <b>1</b> (10): 16063. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2016NatRM...116063L">2016NatRM...116063L</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnatrevmats.2016.63">10.1038/natrevmats.2016.63</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/2058-8437">2058-8437</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:10104005">10104005</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Reviews+Materials&rft.atitle=Materials+and+technologies+for+soft+implantable+neuroprostheses&rft.volume=1&rft.issue=10&rft.pages=16063&rft.date=2016&rft_id=info%3Adoi%2F10.1038%2Fnatrevmats.2016.63&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A10104005%23id-name%3DS2CID&rft.issn=2058-8437&rft_id=info%3Abibcode%2F2016NatRM...116063L&rft.aulast=Lacour&rft.aufirst=St%C3%A9phanie+P.&rft.au=Courtine%2C+Gr%C3%A9goire&rft.au=Guck%2C+Jochen&rft_id=http%3A%2F%2Finfoscience.epfl.ch%2Frecord%2F221479%2Ffiles%2Fnatrevmats201663.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-ChoiLee2016-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-ChoiLee2016_51-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChoiLeeGhaffariHyeon2016" class="citation journal cs1">Choi, Suji; Lee, Hyunjae; Ghaffari, Roozbeh; Hyeon, Taeghwan; Kim, Dae-Hyeong (June 2016). "Recent Advances in Flexible and Stretchable Bio-Electronic Devices Integrated with Nanomaterials". <i>Advanced Materials</i>. <b>28</b> (22): <span class="nowrap">4203–</span>4218. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2016AdM....28.4203C">2016AdM....28.4203C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fadma.201504150">10.1002/adma.201504150</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0935-9648">0935-9648</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26779680">26779680</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:205264592">205264592</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Advanced+Materials&rft.atitle=Recent+Advances+in+Flexible+and+Stretchable+Bio-Electronic+Devices+Integrated+with+Nanomaterials&rft.volume=28&rft.issue=22&rft.pages=%3Cspan+class%3D%22nowrap%22%3E4203-%3C%2Fspan%3E4218&rft.date=2016-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A205264592%23id-name%3DS2CID&rft_id=info%3Abibcode%2F2016AdM....28.4203C&rft.issn=0935-9648&rft_id=info%3Adoi%2F10.1002%2Fadma.201504150&rft_id=info%3Apmid%2F26779680&rft.aulast=Choi&rft.aufirst=Suji&rft.au=Lee%2C+Hyunjae&rft.au=Ghaffari%2C+Roozbeh&rft.au=Hyeon%2C+Taeghwan&rft.au=Kim%2C+Dae-Hyeong&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-52"><span class="mw-cite-backlink"><b><a href="#cite_ref-52">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKuhn2005" class="citation book cs1">Kuhn, Liisa T. (2005-01-01). "Chapter 6 - BIOMATERIALS". In Enderle, John D.; Blanchard, Susan M.; Bronzino, Joseph D. (eds.). <i>Introduction to Biomedical Engineering</i> (2nd ed.). Boston: Academic Press. pp. <span class="nowrap">255–</span>312. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-12-238662-6" title="Special:BookSources/978-0-12-238662-6"><bdi>978-0-12-238662-6</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Chapter+6+-+BIOMATERIALS&rft.btitle=Introduction+to+Biomedical+Engineering&rft.place=Boston&rft.pages=%3Cspan+class%3D%22nowrap%22%3E255-%3C%2Fspan%3E312&rft.edition=2nd&rft.pub=Academic+Press&rft.date=2005-01-01&rft.isbn=978-0-12-238662-6&rft.aulast=Kuhn&rft.aufirst=Liisa+T.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-53"><span class="mw-cite-backlink"><b><a href="#cite_ref-53">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPartlow2022" class="citation web cs1">Partlow, William (2022-03-13). <a rel="nofollow" class="external text" href="https://www.beyonddiscovery.org/biomaterials/1.html">"1 - Biomaterials"</a>. <i>Beyond Discovery</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Beyond+Discovery&rft.atitle=1+-+Biomaterials&rft.date=2022-03-13&rft.aulast=Partlow&rft.aufirst=William&rft_id=https%3A%2F%2Fwww.beyonddiscovery.org%2Fbiomaterials%2F1.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-54"><span class="mw-cite-backlink"><b><a href="#cite_ref-54">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://depts.washington.edu/matseed/ces_guide/microstructure.htm#:~:text=Microstructure%20are%20material%20structures%20seen,,%20grains,%20and%20grain%20boundary.">"Microstructure"</a>. <i>CES Information Guide - Materials Science Engineering</i>. depts.washington.edu<span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=CES+Information+Guide+-+Materials+Science+Engineering&rft.atitle=Microstructure&rft_id=https%3A%2F%2Fdepts.washington.edu%2Fmatseed%2Fces_guide%2Fmicrostructure.htm%23%3A~%3Atext%3DMicrostructure%2520are%2520material%2520structures%2520seen%2C%2C%2520grains%2C%2520and%2520grain%2520boundary.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-55"><span class="mw-cite-backlink"><b><a href="#cite_ref-55">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMercierZambelliKurz2002" class="citation book cs1">Mercier, Jean-Pierre; Zambelli, Gérald; Kurz, Wilfried (2002). <a rel="nofollow" class="external text" href="https://www.sciencedirect.com/book/9782842992866/introduction-to-materials-science"><i>Introduction to Materials Science</i></a>. Elsevier. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9782842992866" title="Special:BookSources/9782842992866"><bdi>9782842992866</bdi></a><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Introduction+to+Materials+Science&rft.pub=Elsevier&rft.date=2002&rft.isbn=9782842992866&rft.aulast=Mercier&rft.aufirst=Jean-Pierre&rft.au=Zambelli%2C+G%C3%A9rald&rft.au=Kurz%2C+Wilfried&rft_id=https%3A%2F%2Fwww.sciencedirect.com%2Fbook%2F9782842992866%2Fintroduction-to-materials-science&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-56"><span class="mw-cite-backlink"><b><a href="#cite_ref-56">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://study.com/academy/lesson/crystalline-structure-definition-structure-bonding.html">"Crystalline Structure: Definition, Structure & Bonding"</a>. <i>Study.com</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Study.com&rft.atitle=Crystalline+Structure%3A+Definition%2C+Structure+%26+Bonding&rft_id=https%3A%2F%2Fstudy.com%2Facademy%2Flesson%2Fcrystalline-structure-definition-structure-bonding.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-57"><span class="mw-cite-backlink"><b><a href="#cite_ref-57">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://opentextbc.ca/chemistry/chapter/10-6-lattice-structures-in-crystalline-solids/">"10.6 Lattice Structures in Crystalline Solids – Chemistry"</a>. <i>opentextbc.ca</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=opentextbc.ca&rft.atitle=10.6+Lattice+Structures+in+Crystalline+Solids+%E2%80%93+Chemistry&rft_id=https%3A%2F%2Fopentextbc.ca%2Fchemistry%2Fchapter%2F10-6-lattice-structures-in-crystalline-solids%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-58"><span class="mw-cite-backlink"><b><a href="#cite_ref-58">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.britannica.com/science/crystal-defect">"crystal defect | Definition, Types, & Facts | Britannica"</a>. <i>www.britannica.com</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.britannica.com&rft.atitle=crystal+defect+%7C+Definition%2C+Types%2C+%26+Facts+%7C+Britannica&rft_id=https%3A%2F%2Fwww.britannica.com%2Fscience%2Fcrystal-defect&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-59"><span class="mw-cite-backlink"><b><a href="#cite_ref-59">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://encyclopedia2.thefreedictionary.com/Macrostructure">"Macrostructure"</a>. <i>TheFreeDictionary.com</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=TheFreeDictionary.com&rft.atitle=Macrostructure&rft_id=https%3A%2F%2Fencyclopedia2.thefreedictionary.com%2FMacrostructure&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-60"><span class="mw-cite-backlink"><b><a href="#cite_ref-60">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://openwetware.org/wiki/Natural_Biomaterials_by_Isabel_Hand">"Natural Biomaterials by Isabel Hand - OpenWetWare"</a>. <i>openwetware.org</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=openwetware.org&rft.atitle=Natural+Biomaterials+by+Isabel+Hand+-+OpenWetWare&rft_id=https%3A%2F%2Fopenwetware.org%2Fwiki%2FNatural_Biomaterials_by_Isabel_Hand&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-61"><span class="mw-cite-backlink"><b><a href="#cite_ref-61">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://irishseaweeds.com/kelp-laminaria-digitata/">"Kelp (Laminaria digitata) – Irish Seaweeds"</a><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-05-06</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Kelp+%28Laminaria+digitata%29+%E2%80%93+Irish+Seaweeds&rft_id=https%3A%2F%2Firishseaweeds.com%2Fkelp-laminaria-digitata%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-62"><span class="mw-cite-backlink"><b><a href="#cite_ref-62">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFReisChiuFericFu2016" class="citation journal cs1">Reis, Lewis A; Chiu, Loraine L Y; Feric, Nicole; Fu, Lara; Radisic, Milica (January 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933503">"Biomaterials in myocardial tissue engineering"</a>. <i>Journal of Tissue Engineering and Regenerative Medicine</i>. <b>10</b> (1): <span class="nowrap">11–</span>28. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fterm.1944">10.1002/term.1944</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/1932-7005">1932-7005</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933503">4933503</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25066525">25066525</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Tissue+Engineering+and+Regenerative+Medicine&rft.atitle=Biomaterials+in+myocardial+tissue+engineering&rft.volume=10&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E11-%3C%2Fspan%3E28&rft.date=2016-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4933503%23id-name%3DPMC&rft.issn=1932-7005&rft_id=info%3Apmid%2F25066525&rft_id=info%3Adoi%2F10.1002%2Fterm.1944&rft.aulast=Reis&rft.aufirst=Lewis+A&rft.au=Chiu%2C+Loraine+L+Y&rft.au=Feric%2C+Nicole&rft.au=Fu%2C+Lara&rft.au=Radisic%2C+Milica&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4933503&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-63"><span class="mw-cite-backlink"><b><a href="#cite_ref-63">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBuehlerYung2009" class="citation journal cs1">Buehler, M. J.; Yung, Y. C. (2009). "Deformation and failure of protein materials in physiologically extreme conditions and disease". <i>Nature Materials</i>. <b>8</b> (3): <span class="nowrap">175–</span>88. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2009NatMa...8..175B">2009NatMa...8..175B</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnmat2387">10.1038/nmat2387</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19229265">19229265</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Materials&rft.atitle=Deformation+and+failure+of+protein+materials+in+physiologically+extreme+conditions+and+disease&rft.volume=8&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E175-%3C%2Fspan%3E88&rft.date=2009&rft_id=info%3Apmid%2F19229265&rft_id=info%3Adoi%2F10.1038%2Fnmat2387&rft_id=info%3Abibcode%2F2009NatMa...8..175B&rft.aulast=Buehler&rft.aufirst=M.+J.&rft.au=Yung%2C+Y.+C.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-64"><span class="mw-cite-backlink"><b><a href="#cite_ref-64">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStuppBraun1997" class="citation journal cs1">Stupp, S. I.; Braun, P. V. (1997). "Molecular manipulation of microstructures: Biomaterials, ceramics, and semiconductors". <i>Science</i>. <b>277</b> (5330): <span class="nowrap">1242–</span>8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.277.5330.1242">10.1126/science.277.5330.1242</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9271562">9271562</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Molecular+manipulation+of+microstructures%3A+Biomaterials%2C+ceramics%2C+and+semiconductors&rft.volume=277&rft.issue=5330&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1242-%3C%2Fspan%3E8&rft.date=1997&rft_id=info%3Adoi%2F10.1126%2Fscience.277.5330.1242&rft_id=info%3Apmid%2F9271562&rft.aulast=Stupp&rft.aufirst=S.+I.&rft.au=Braun%2C+P.+V.&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-65"><span class="mw-cite-backlink"><b><a href="#cite_ref-65">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKlemmHeubleinFinkBohn2005" class="citation journal cs1">Klemm, D; Heublein, B; Fink, H. P.; Bohn, A (2005). "Cellulose: Fascinating biopolymer and sustainable raw material". <i>Angewandte Chemie International Edition</i>. <b>44</b> (22): <span class="nowrap">3358–</span>93. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fanie.200460587">10.1002/anie.200460587</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15861454">15861454</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Angewandte+Chemie+International+Edition&rft.atitle=Cellulose%3A+Fascinating+biopolymer+and+sustainable+raw+material&rft.volume=44&rft.issue=22&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3358-%3C%2Fspan%3E93&rft.date=2005&rft_id=info%3Adoi%2F10.1002%2Fanie.200460587&rft_id=info%3Apmid%2F15861454&rft.aulast=Klemm&rft.aufirst=D&rft.au=Heublein%2C+B&rft.au=Fink%2C+H.+P.&rft.au=Bohn%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-66"><span class="mw-cite-backlink"><b><a href="#cite_ref-66">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKonwarh2019" class="citation journal cs1">Konwarh, Rocktotpal (2019). "Can the venerated silk be the next-generation nanobiomaterial for biomedical-device designing, regenerative medicine and drug delivery? Prospects and hitches". <i>Bio-Design and Manufacturing</i>. <b>2</b> (4): <span class="nowrap">278–</span>286. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs42242-019-00052-9">10.1007/s42242-019-00052-9</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:208833880">208833880</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bio-Design+and+Manufacturing&rft.atitle=Can+the+venerated+silk+be+the+next-generation+nanobiomaterial+for+biomedical-device+designing%2C+regenerative+medicine+and+drug+delivery%3F+Prospects+and+hitches&rft.volume=2&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E278-%3C%2Fspan%3E286&rft.date=2019&rft_id=info%3Adoi%2F10.1007%2Fs42242-019-00052-9&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A208833880%23id-name%3DS2CID&rft.aulast=Konwarh&rft.aufirst=Rocktotpal&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABiomaterial" class="Z3988"></span></span> </li> <li id="cite_note-67"><span class="mw-cite-backlink"><b><a href="#cite_ref-67">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMehrotra2019" class="citation journal cs1">Mehrotra, Shreya (2019). "Comprehensive Review on Silk at Nanoscale for Regenerative Medicine and Allied Applications". <i>ACS Biomater. Sci. Eng</i>. <b>5</b> (5): <span class="nowrap">2054–</span>2078. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2Facsbiomaterials.8b01560">10.1021/acsbiomaterials.8b01560</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/33405710">33405710</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:132470283">132470283</a>.</cite><span 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