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<!doctype html> <html lang="pt"> <head> <title>Explaining Contemporary Patterns of Cannabis Teratology | 25508</title> <meta name="keywords" content="Albert Stuart Reece and Gary Kenneth Hulse , "/> <meta name="description" content="Cannabis has been shown to be teratogenic in cells, animals and humans. Particular targets of prenatal exposure include brain, heart and blood vessels and ..25508"/> <meta name="citation_publisher" content="Longdom Publishing SL" /> <meta name="citation_journal_title" content="Pediatria Cl铆nica: Acesso Aberto"> <meta name="citation_title" content="Explaining Contemporary Patterns of Cannabis Teratology "> <meta name="citation_author" content="Albert Stuart Reece" /> <meta name="citation_author" content="Gary Kenneth Hulse" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="4"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Cannabis has been shown to be teratogenic in cells, animals and humans. Particular targets of prenatal exposure include brain, heart and blood vessels and chromosomal segregation. Three longitudinal clinical studies report concerning cortical dysfunction persisting into adolescence and beyond, which are pertinent to the autism epidemic. Increased rates of congenital heart defects, gastroschisis, anencephaly and others have been reported. The pattern of neuroteratology seen after cannabis exposure strongly suggests a spectrum of dysfunction from mild to moderate to very severe. Downs syndrome, atrial septal defect (secundum type), ventricular septal defect and anotia / microtia were noted to be more common in prenatally cannabis exposed children in a large US epidemiological study which would appear to have been confirmed by recent experience in Colorado and other USA states. Studies in cells, together with the above mentioned epidemiology, implicate cannabidiol, cannabichromene, cannabidivarin and other cannabinoids in significant genotoxicity and / or epigenotoxicity. Notch signalling has recently been shown to be altered by cannabinoids, which is highly pertinent to morphogenesis of the neuraxis and cardiovasculature, and also to congenital and inheritable cancer induction. It is felt that subtle neurobehavioural psychosocial and educational deficits will likely be the most common expression of cannabinoid teratology at the population level. The far reaching implications of this wide spectrum of neuroteratological, pediatric cardiological and other defects and deficits should be carefully considered in increasingly liberal paradigms. Hence it is shown that the disparate presentations of cannabis teratology relate directly and closely to the distribution of CB1R’s across the developing embryo and account for the polymorphous clinical presentations. 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</div>     <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Peri贸dicos de Acesso Aberto</h6> <div class="card-body p-0 scroll_mang"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://portuguese.longdom.org/agri-and-aquaculture-journals.html" title="Clique aqui">Agro e Aquicultura</a><br> <a class="nav-item nav-link" href="https://portuguese.longdom.org/food-and-nutrition-journals.html" title="Clique aqui">Alimentos e Nutri莽茫o</a><br> <a class="nav-item nav-link" href="https://portuguese.longdom.org/bioinformatics-and-systems-biology-journals.html" title="Clique aqui">Bioinform谩tica e Biologia de Sistemas</a><br> <a class="nav-item nav-link" href="https://portuguese.longdom.org/biochemistry-journals.html" title="Clique aqui">Bioqu铆mica</a><br> <a class="nav-item nav-link" href="https://portuguese.longdom.org/clinical-sciences-journals.html" title="Clique aqui">Ci锚ncias Cl铆nicas</a><br> <a 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Particular targets of prenatal exposure include brain, heart and blood vessels and chromosomal segregation. Three longitudinal clinical studies report concerning cortical dysfunction persisting into adolescence and beyond, which are pertinent to the autism epidemic. Increased rates of congenital heart defects, gastroschisis, anencephaly and others have been reported. The pattern of neuroteratology seen after cannabis exposure strongly suggests a spectrum of dysfunction from mild to moderate to very severe. Downs syndrome, atrial septal defect (secundum type), ventricular septal defect and anotia / microtia were noted to be more common in prenatally cannabis exposed children in a large US epidemiological study which would appear to have been confirmed by recent experience in Colorado and other USA states. Studies in cells, together with the above mentioned epidemiology, implicate cannabidiol, cannabichromene, cannabidivarin and other cannabinoids in significant genotoxicity and / or epigenotoxicity. Notch signalling has recently been shown to be altered by cannabinoids, which is highly pertinent to morphogenesis of the neuraxis and cardiovasculature, and also to congenital and inheritable cancer induction. It is felt that subtle neurobehavioural psychosocial and educational deficits will likely be the most common expression of cannabinoid teratology at the population level. The far reaching implications of this wide spectrum of neuroteratological, pediatric cardiological and other defects and deficits should be carefully considered in increasingly liberal paradigms. Hence it is shown that the disparate presentations of cannabis teratology relate directly and closely to the distribution of CB1R’s across the developing embryo and account for the polymorphous clinical presentations.</p> <div class="alert alert-info text-left"><b>Isen莽茫o de responsabilidade:</b> Este resumo foi traduzido com recurso a ferramentas de intelig锚ncia artificial e ainda n茫o foi revisto ou verificado.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Compartilhe este artigo</a> <a title="Clique aqui" target="_blank" href="https://www.facebook.com/sharer.php?u=https://portuguese.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Clique aqui" target="_blank" href="https://twitter.com/share?url=https://portuguese.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Clique aqui" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://portuguese.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Clique aqui" target="_blank" href="https://plus.google.com/share?url=https://portuguese.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Links de conte煤do</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://portuguese.longdom.org/privacy-policy.html" title="Clique aqui">pol铆tica de Privacidade</a></li> <li><a class="" href="https://portuguese.longdom.org/terms-conditions.html" title="Clique aqui">termos e Condi莽玫es</a></li> <li><a class="" href="https://portuguese.longdom.org/authors-reviewers-editors.html" title="Clique aqui">Autores, Revisores e Edi莽茫o</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contato Longdom</h4> <p><strong>Grupo Longdom SA</strong><br /> Avenida Roger Vandendriessche,<br /> 18, 1150 Bruxelas, B茅lgica<br /> Telefone: +442038085340<br /> <strong>E-mail:</strong> <a class="white" href="mailto:info@longdom.org" title="Clique aqui">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Conectar</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Clique aqui" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Clique aqui" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="Clique aqui" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="Clique aqui" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>direito autoral © 2024 <a href="https://portuguese.longdom.org/" title="Clique aqui" class="white">Longdom Publishing SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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