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Explaining Contemporary Patterns of Cannabis Teratology | 25508

<!doctype html> <html lang="hi"> <head> <title>Explaining Contemporary Patterns of Cannabis Teratology | 25508</title> <meta name="keywords" content="Albert Stuart Reece and Gary Kenneth Hulse , "/> <meta name="description" content="Cannabis has been shown to be teratogenic in cells, animals and humans. Particular targets of prenatal exposure include brain, heart and blood vessels and ..25508"/> <meta name="citation_publisher" content="लॉन्गडम पब्लिशिंग एसएल" /> <meta name="citation_journal_title" content="क्लिनिकल पीडियाट्रिक्स: ओपन एक्सेस"> <meta name="citation_title" content="Explaining Contemporary Patterns of Cannabis Teratology "> <meta name="citation_author" content="Albert Stuart Reece" /> <meta name="citation_author" content="Gary Kenneth Hulse" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="4"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Cannabis has been shown to be teratogenic in cells, animals and humans. Particular targets of prenatal exposure include brain, heart and blood vessels and chromosomal segregation. Three longitudinal clinical studies report concerning cortical dysfunction persisting into adolescence and beyond, which are pertinent to the autism epidemic. Increased rates of congenital heart defects, gastroschisis, anencephaly and others have been reported. The pattern of neuroteratology seen after cannabis exposure strongly suggests a spectrum of dysfunction from mild to moderate to very severe. Downs syndrome, atrial septal defect (secundum type), ventricular septal defect and anotia / microtia were noted to be more common in prenatally cannabis exposed children in a large US epidemiological study which would appear to have been confirmed by recent experience in Colorado and other USA states. Studies in cells, together with the above mentioned epidemiology, implicate cannabidiol, cannabichromene, cannabidivarin and other cannabinoids in significant genotoxicity and / or epigenotoxicity. Notch signalling has recently been shown to be altered by cannabinoids, which is highly pertinent to morphogenesis of the neuraxis and cardiovasculature, and also to congenital and inheritable cancer induction. It is felt that subtle neurobehavioural psychosocial and educational deficits will likely be the most common expression of cannabinoid teratology at the population level. The far reaching implications of this wide spectrum of neuroteratological, pediatric cardiological and other defects and deficits should be carefully considered in increasingly liberal paradigms. Hence it is shown that the disparate presentations of cannabis teratology relate directly and closely to the distribution of CB1R&rsquo;s across the developing embryo and account for the polymorphous clinical presentations. 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class="">Explaining Contemporary Patterns of Cannabis Teratology </h3> <p> <i class="fas fa-user"></i> Albert Stuart Reece and Gary Kenneth Hulse </p> <p>Cannabis has been shown to be teratogenic in cells, animals and humans. Particular targets of prenatal exposure include brain, heart and blood vessels and chromosomal segregation. Three longitudinal clinical studies report concerning cortical dysfunction persisting into adolescence and beyond, which are pertinent to the autism epidemic. Increased rates of congenital heart defects, gastroschisis, anencephaly and others have been reported. The pattern of neuroteratology seen after cannabis exposure strongly suggests a spectrum of dysfunction from mild to moderate to very severe. Downs syndrome, atrial septal defect (secundum type), ventricular septal defect and anotia / microtia were noted to be more common in prenatally cannabis exposed children in a large US epidemiological study which would appear to have been confirmed by recent experience in Colorado and other USA states. Studies in cells, together with the above mentioned epidemiology, implicate cannabidiol, cannabichromene, cannabidivarin and other cannabinoids in significant genotoxicity and / or epigenotoxicity. Notch signalling has recently been shown to be altered by cannabinoids, which is highly pertinent to morphogenesis of the neuraxis and cardiovasculature, and also to congenital and inheritable cancer induction. It is felt that subtle neurobehavioural psychosocial and educational deficits will likely be the most common expression of cannabinoid teratology at the population level. The far reaching implications of this wide spectrum of neuroteratological, pediatric cardiological and other defects and deficits should be carefully considered in increasingly liberal paradigms. Hence it is shown that the disparate presentations of cannabis teratology relate directly and closely to the distribution of CB1R&rsquo;s across the developing embryo and account for the polymorphous clinical presentations.</p> <div class="alert alert-info text-left"><b>अस्वीकरण:</b> इस सार का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया था और अभी तक इसकी समीक्षा या सत्यापन नहीं किया गया है।</div> <div class="nav social-icons"> <a class="nav-link w-auto">इस लेख का हिस्सा</a> <a title="यहाँ क्लिक करें" target="_blank" href="https://www.facebook.com/sharer.php?u=https://hindi.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="यहाँ क्लिक करें" target="_blank" href="https://twitter.com/share?url=https://hindi.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="यहाँ क्लिक करें" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://hindi.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="यहाँ क्लिक करें" target="_blank" href="https://plus.google.com/share?url=https://hindi.longdom.org/abstract/explaining-contemporary-patterns-of-cannabis-teratology-25508.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">सामग्री लिंक</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://hindi.longdom.org/privacy-policy.html" title="यहाँ क्लिक करें">गोपनीयता नीति</a></li> <li><a class="" href="https://hindi.longdom.org/terms-conditions.html" title="यहाँ क्लिक करें">नियम एवं शर्तें</a></li> <li><a class="" href="https://hindi.longdom.org/authors-reviewers-editors.html" title="यहाँ क्लिक करें">लेखक, समीक्षक और संपादक</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">लॉन्गडोम से संपर्क करें</h4> <p><strong>लॉन्गडम ग्रुप एसए</strong><br /> एवेन्यू रोजर वांडेन्ड्रिस्शे,<br /> 18, 1150 ब्रुसेल्स, बेल्जियम<br /> फ़ोन: +442038085340<br/> <strong>ईमेल:</strong> <a class='white' href='mailto:info@longdom.org' title='यहां क्लिक करें'>info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">जोड़ना</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="यहाँ क्लिक करें" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="यहाँ क्लिक करें" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="यहाँ क्लिक करें" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="यहाँ क्लिक करें" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>कॉपीराइट &copy; 2024 <a href="https://hindi.longdom.org/" title="यहाँ क्लिक करें" class="white">लॉन्गडम पब्लिशिंग एसएल</a>.</p> </div> </div> </div> </footer> <!--========================== Scroll To Top ============================--> <a href="#0" class="cd-top js-cd-top">Top</a> <!-- Optional JavaScript --> <!-- jQuery first, then Popper.js, then Bootstrap JS --> <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script> <!--Get the app icon js--> <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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