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href="https://tt.wikipedia.org/wiki/BLNK" title="BLNK – Tatar" lang="tt" hreflang="tt" data-title="BLNK" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/BLNK" title="BLNK – Ukrainian" lang="uk" hreflang="uk" data-title="BLNK" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q21173210#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> 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style="text-align:center;font-size:125%;font-weight:bold">BLNK</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q9QUN3%20or%20Q8WV28">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q9QUN3,Q8WV28">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2EO6">2EO6</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/14211">BLNK</a></span>, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca, B-cell linker, B cell linker</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/604515">604515</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:96878">96878</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=32038">32038</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=BLNK">BLNK</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000095585">BLNK - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_10.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/300px-Ideogram_human_chromosome_10.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/450px-Ideogram_human_chromosome_10.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/600px-Ideogram_human_chromosome_10.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_10_(human)" class="mw-redirect" title="Chromosome 10 (human)">Chromosome 10 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_10_ideogram.svg" class="mw-file-description" title="Chromosome 10 (human)"><img alt="Chromosome 10 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/300px-Human_chromosome_10_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/450px-Human_chromosome_10_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_10_ideogram.svg/600px-Human_chromosome_10_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 206.14779284524px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for BLNK"><img alt="Genomic location for BLNK" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 212.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for BLNK"><img alt="Genomic location for BLNK" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">10q24.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">96,189,171 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">96,271,587 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/260px-Ideogram_house_mouse_chromosome_19.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/390px-Ideogram_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/520px-Ideogram_house_mouse_chromosome_19.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 19 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/300px-Ideogram_of_house_mouse_chromosome_19.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/450px-Ideogram_of_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/600px-Ideogram_of_house_mouse_chromosome_19.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 190.66867691186px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for BLNK"><img alt="Genomic location for BLNK" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 196.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for BLNK"><img alt="Genomic location for BLNK" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">19 C3|19 34.26 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">40,917,371 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">40,982,978 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000095585">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">oral cavity</li><br /><li style="line-height: 137%;">corpus epididymis</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">jejunal mucosa</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">epithelium of nasopharynx</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">mucosa of pharynx</li><br /><li style="line-height: 137%;">lymph node</li><br /><li style="line-height: 137%;">right lobe of liver</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000061132">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">molar</li><br /><li style="line-height: 137%;">left colon</li><br /><li style="line-height: 137%;">seminal vesicula</li><br /><li style="line-height: 137%;">tail of embryo</li><br /><li style="line-height: 137%;">submandibular gland</li><br /><li style="line-height: 137%;">temporal muscle</li><br /><li style="line-height: 137%;">Ileal epithelium</li><br /><li style="line-height: 137%;">tibiofemoral joint</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000095585">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_BLNK_207655_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/PBB_GE_BLNK_207655_s_at_fs.png/250px-PBB_GE_BLNK_207655_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/PBB_GE_BLNK_207655_s_at_fs.png/375px-PBB_GE_BLNK_207655_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/04/PBB_GE_BLNK_207655_s_at_fs.png/500px-PBB_GE_BLNK_207655_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/29760/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005068">transmembrane receptor protein tyrosine kinase adaptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005622">intracellular anatomical structure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0036464">cytoplasmic ribonucleoprotein granule</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006959">humoral immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030183">B cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035556">intracellular signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042113">B cell activation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006954">inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009967">positive regulation of signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007169">transmembrane receptor protein tyrosine kinase signaling pathway</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=29760&rn=1">29760</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=17060&rn=1">17060</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000095585;db=core">ENSG00000095585</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000061132;db=core">ENSMUSG00000061132</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q8WV28">Q8WV28</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9QUN3">Q9QUN3</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001114094">NM_001114094</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001258440">NM_001258440</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001258441">NM_001258441</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001258442">NM_001258442</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_013314">NM_013314</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008528">NM_008528</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001365054">NM_001365054</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001107566">NP_001107566</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001245369">NP_001245369</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001245370">NP_001245370</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001245371">NP_001245371</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_037446">NP_037446</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032554">NP_032554</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001351983">NP_001351983</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr10:96189171-96271587">Chr 10: 96.19 – 96.27 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr19:40917371-40982978">Chr 19: 40.92 – 40.98 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q20970133" class="extiw" title="d:Q20970133">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18252130" class="extiw" title="d:Q18252130">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>B-cell linker (BLNK)</b> protein is expressed in <a href="/wiki/B_cell" title="B cell">B cells</a> and <a href="/wiki/Macrophage" title="Macrophage">macrophages</a> and plays a large role in <a href="/wiki/B_cell_receptor" class="mw-redirect" title="B cell receptor">B cell receptor</a> signaling.<sup id="cite_ref-pmid15654340_5-0" class="reference"><a href="#cite_note-pmid15654340-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Like all <a href="/wiki/Signal_transducing_adaptor_protein" title="Signal transducing adaptor protein">adaptor proteins</a>, BLNK has no known intrinsic enzymatic activity.<sup id="cite_ref-:0_6-0" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Its function is to temporally and spatially coordinate and regulate <a href="/wiki/Upstream_and_downstream_(transduction)" title="Upstream and downstream (transduction)">downstream</a> signaling effectors in <a href="/wiki/B_cell_receptor" class="mw-redirect" title="B cell receptor">B cell receptor</a> (BCR) signaling, which is important in B cell development.<sup id="cite_ref-pmid10023776_7-0" class="reference"><a href="#cite_note-pmid10023776-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Binding of these downstream effectors is dependent on BLNK phosphorylation.<sup id="cite_ref-pmid9697839_8-0" class="reference"><a href="#cite_note-pmid9697839-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:1_9-0" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> BLNK is encoded by the <i>BLNK</i> <a href="/wiki/Gene" title="Gene">gene</a><sup id="cite_ref-pmid9697839_8-1" class="reference"><a href="#cite_note-pmid9697839-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_10-0" class="reference"><a href="#cite_note-entrez-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> and is also known as <b>SLP-65</b>,<sup id="cite_ref-pmid9705962_11-0" class="reference"><a href="#cite_note-pmid9705962-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> <b>BASH</b>,<sup id="cite_ref-pmid9834055_12-0" class="reference"><a href="#cite_note-pmid9834055-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> and <b>BCA</b>.<sup id="cite_ref-pmid9683264_13-0" class="reference"><a href="#cite_note-pmid9683264-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure_and_localization">Structure and localization</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=B-cell_linker&action=edit&section=1" title="Edit section: Structure and localization"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>BLNK consists of a N-terminal <a href="/wiki/Leucine_zipper" title="Leucine zipper">leucine zipper</a> motif followed by an acidic region, a proline-rich region, and a C-terminal <a href="/wiki/SH2_domain" title="SH2 domain">SH2 domain</a>.<sup id="cite_ref-:2_14-0" class="reference"><a href="#cite_note-:2-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid15654340_5-1" class="reference"><a href="#cite_note-pmid15654340-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> The leucine zipper motif allows BLNK to localize to the plasma membrane, presumably by coiled-coil interactions with a membrane protein.<sup id="cite_ref-pmid15654340_5-2" class="reference"><a href="#cite_note-pmid15654340-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> This leucine zipper motif distinguishes BLNK from <a href="/wiki/Lymphocyte_cytosolic_protein_2" title="Lymphocyte cytosolic protein 2">lymphoctye cytosolic protein 2</a>, also known as LCP-2 or SLP-76, which plays a similar role in <a href="/wiki/T-cell_receptor" title="T-cell receptor">T cell receptor</a> signaling.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Although LCP-2 has an N-terminal heptad-like organization of leucine and isoleucine residues like BLNK, it has not been experimentally shown to have the leucine zipper motif.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Recruitment of BLNK to the plasma membrane is also achieved by binding of the SH2 domain of BLNK to a non-<a href="/wiki/Immunoreceptor_tyrosine-based_activation_motif" title="Immunoreceptor tyrosine-based activation motif">ITAM</a> phospho-tyrosine on the cytoplasmic domain of <a href="/wiki/CD79A" title="CD79A">CD79A</a>, which is a part of <a href="/wiki/CD79A" title="CD79A">Igα</a> and the B cell receptor complex.<sup id="cite_ref-pmid11449366_17-0" class="reference"><a href="#cite_note-pmid11449366-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11909947_18-0" class="reference"><a href="#cite_note-pmid11909947-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid15699130_19-0" class="reference"><a href="#cite_note-pmid15699130-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=B-cell_linker&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:B_cell_signalling.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/B_cell_signalling.png/220px-B_cell_signalling.png" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/B_cell_signalling.png/330px-B_cell_signalling.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/39/B_cell_signalling.png/440px-B_cell_signalling.png 2x" data-file-width="960" data-file-height="720" /></a><figcaption>BLNK’s function and interaction shown in a schematic of BCR signaling pathways. BCR antigen recognition activates <a href="/wiki/Src_family_kinase" title="Src family kinase">Src family kinases</a>, including the <a href="/wiki/Syk" class="mw-redirect" title="Syk">SYK</a> and <a href="/wiki/Btk-type_zinc_finger" title="Btk-type zinc finger">BTK</a> <a href="/wiki/Tyrosine_kinase" title="Tyrosine kinase">tyrosine kinases</a>. Syk then phosphorylates BLNK, which can recruit downstream signaling molecules such as <a href="/wiki/Grb2" class="mw-redirect" title="Grb2">Grb2</a>, <a href="/wiki/PLCG2" title="PLCG2">PLCG2</a>, <a href="/wiki/Vav_(protein)" title="Vav (protein)">Vav</a> and <a href="/wiki/NCK1" title="NCK1">Nck</a>.</figcaption></figure> <p>BLNK's function and importance in B cell development were first illustrated in BLNK deficient DT40 cells, a <a href="/wiki/Chicken" title="Chicken">chicken</a> <a href="/wiki/B-cell" class="mw-redirect" title="B-cell">B cell</a> line.<sup id="cite_ref-pmid10023776_7-1" class="reference"><a href="#cite_note-pmid10023776-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> DT40 cells had interrupted B cell development: there was no calcium mobilization response in the B cell, impaired activation of the <a href="/wiki/Mitogen-activated_protein_kinase" title="Mitogen-activated protein kinase">mitogen-activated protein (MAP) kinases</a> <a href="/wiki/P38_mitogen-activated_protein_kinases" title="P38 mitogen-activated protein kinases">p38</a>, <a href="/wiki/C-Jun_N-terminal_kinases" title="C-Jun N-terminal kinases">JNK</a>, and somewhat inhibited <a href="/wiki/Extracellular_signal-regulated_kinases" title="Extracellular signal-regulated kinases">ERK</a> activation upon (BCR) activation as compared to wild type DT40 cells.<sup id="cite_ref-pmid10023776_7-2" class="reference"><a href="#cite_note-pmid10023776-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> In <a href="/wiki/Knockout_mouse" title="Knockout mouse">knockout mice</a>, BLNK deficiency results in a partial block in B cell development,<sup id="cite_ref-pmid10591180_20-0" class="reference"><a href="#cite_note-pmid10591180-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10583957_21-0" class="reference"><a href="#cite_note-pmid10583957-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> and in humans BLNK deficiency results in a much more profound block in B cell development.<sup id="cite_ref-pmid10583958_22-0" class="reference"><a href="#cite_note-pmid10583958-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid15654340_5-3" class="reference"><a href="#cite_note-pmid15654340-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins.<sup id="cite_ref-:0_6-1" class="reference"><a href="#cite_note-:0-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> BLNK is essential for normal B-cell development as part of the B cell receptor signaling pathway. [supplied by OMIM]<sup id="cite_ref-entrez_10-1" class="reference"><a href="#cite_note-entrez-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_24-0" class="reference"><a href="#cite_note-:4-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p><p>Evidence also suggests that BLNK may have tumor suppressive activity through its interaction with <a href="/wiki/Bruton%27s_tyrosine_kinase" title="Bruton's tyrosine kinase">Bruton's tyrosine kinase</a> (Btk) <sup id="cite_ref-pmid12093870_25-0" class="reference"><a href="#cite_note-pmid12093870-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10498607_26-0" class="reference"><a href="#cite_note-pmid10498607-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> and regulation of the pre-B cell checkpoint.<sup id="cite_ref-:2_14-1" class="reference"><a href="#cite_note-:2-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Phosphorylation_and_interactions">Phosphorylation and interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=B-cell_linker&action=edit&section=3" title="Edit section: Phosphorylation and interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The acidic region of BLNK contains several inducibly phosphorylated <a href="/wiki/Tyrosine" title="Tyrosine">tyrosine</a> residues, at least five of which are found in humans.<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> Evidence suggests that BLNK is phosphorylated by the <a href="/wiki/Tyrosine-protein_kinase_SYK" title="Tyrosine-protein kinase SYK">tyrosine-protein kinase Syk</a> after B cell receptor activation.<sup id="cite_ref-pmid9697839_8-2" class="reference"><a href="#cite_note-pmid9697839-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:1_9-1" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:4_24-1" class="reference"><a href="#cite_note-:4-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> Phosphorylation of these residues provides docking sites necessary for downstream <a href="/wiki/Protein%E2%80%93protein_interaction" title="Protein–protein interaction">protein-protein interactions</a> between BLNK and the SH2 domain-containing proteins <a href="/wiki/Grb2" class="mw-redirect" title="Grb2">Grb2</a>,<sup id="cite_ref-pmid9697839_8-3" class="reference"><a href="#cite_note-pmid9697839-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9705962_11-1" class="reference"><a href="#cite_note-pmid9705962-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11449366_17-1" class="reference"><a href="#cite_note-pmid11449366-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10820378_30-0" class="reference"><a href="#cite_note-pmid10820378-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> <a href="/wiki/PLCG2" title="PLCG2">PLCG2</a>, <a href="/wiki/Bruton%27s_tyrosine_kinase" title="Bruton's tyrosine kinase">Btk</a>, the <a href="/wiki/Vav_(protein)" title="Vav (protein)">Vav</a> protein family, and <a href="/wiki/NCK1" title="NCK1">Nck</a>.<sup id="cite_ref-pmid12456653_31-0" class="reference"><a href="#cite_note-pmid12456653-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:1_9-2" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9697839_8-4" class="reference"><a href="#cite_note-pmid9697839-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> BLNK has also been shown to interact with <a href="/wiki/SH3KBP1" title="SH3KBP1">SH3KBP1</a><sup id="cite_ref-pmid11071869_32-0" class="reference"><a href="#cite_note-pmid11071869-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/MAP4K1" title="MAP4K1">MAP4K1</a>.<sup id="cite_ref-pmid11514608_33-0" class="reference"><a href="#cite_note-pmid11514608-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> A more recent <a href="/wiki/Mass_spectrometry" title="Mass spectrometry">mass spectrometry</a> study of BLNK in DT40 cells found that at least 41 unique serine, threonine, and tyrosine residues are phosphorylated on BLNK.<sup id="cite_ref-pmid19372136_34-0" class="reference"><a href="#cite_note-pmid19372136-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=B-cell_linker&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000095585">GRCh38: Ensembl release 89: ENSG00000095585</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000061132">GRCm38: Ensembl release 89: ENSMUSG00000061132</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output 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(identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12456653">12456653</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+EMBO+Journal&rft.atitle=BLNK%3A+molecular+scaffolding+through+%27cis%27-mediated+organization+of+signaling+proteins&rft.volume=21&rft.issue=23&rft.pages=6461-6472&rft.date=2002-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC136961%23id-name%3DPMC&rft_id=info%3Apmid%2F12456653&rft_id=info%3Adoi%2F10.1093%2Femboj%2Fcdf658&rft.aulast=Chiu&rft.aufirst=CW&rft.au=Dalton%2C+M&rft.au=Ishiai%2C+M&rft.au=Kurosaki%2C+T&rft.au=Chan%2C+AC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC136961&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></span> </li> <li id="cite_note-pmid11071869-32"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11071869_32-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWatanabeTakeTakedaYu2000" class="citation journal cs1">Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). <a rel="nofollow" class="external text" href="https://zenodo.org/record/1229524">"Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes"</a>. <i>Biochemical and Biophysical Research Communications</i>. <b>278</b> (1): 167–174. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.2000.3760">10.1006/bbrc.2000.3760</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11071869">11071869</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Characterization+of+the+CIN85+adaptor+protein+and+identification+of+components+involved+in+CIN85+complexes&rft.volume=278&rft.issue=1&rft.pages=167-174&rft.date=2000-11&rft_id=info%3Adoi%2F10.1006%2Fbbrc.2000.3760&rft_id=info%3Apmid%2F11071869&rft.aulast=Watanabe&rft.aufirst=S&rft.au=Take%2C+H&rft.au=Takeda%2C+K&rft.au=Yu%2C+ZX&rft.au=Iwata%2C+N&rft.au=Kajigaya%2C+S&rft_id=https%3A%2F%2Fzenodo.org%2Frecord%2F1229524&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></span> </li> <li id="cite_note-pmid11514608-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11514608_33-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTsujiOkamotoYamadaOkamoto2001" class="citation journal cs1">Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, et al. (August 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193495">"B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1"</a>. <i>The Journal of Experimental Medicine</i>. <b>194</b> (4): 529–539. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1084%2Fjem.194.4.529">10.1084/jem.194.4.529</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193495">2193495</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11514608">11514608</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Experimental+Medicine&rft.atitle=B+cell+adaptor+containing+src+homology+2+domain+%28BASH%29+links+B+cell+receptor+signaling+to+the+activation+of+hematopoietic+progenitor+kinase+1&rft.volume=194&rft.issue=4&rft.pages=529-539&rft.date=2001-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2193495%23id-name%3DPMC&rft_id=info%3Apmid%2F11514608&rft_id=info%3Adoi%2F10.1084%2Fjem.194.4.529&rft.aulast=Tsuji&rft.aufirst=S&rft.au=Okamoto%2C+M&rft.au=Yamada%2C+K&rft.au=Okamoto%2C+N&rft.au=Goitsuka%2C+R&rft.au=Arnold%2C+R&rft.au=Kiefer%2C+F&rft.au=Kitamura%2C+D&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2193495&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></span> </li> <li id="cite_note-pmid19372136-34"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19372136_34-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFOellerichGrønborgNeumannHsiao2009" class="citation journal cs1">Oellerich T, Grønborg M, Neumann K, Hsiao HH, Urlaub H, Wienands J (July 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709198">"SLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteins"</a>. <i>Molecular & Cellular Proteomics</i>. <b>8</b> (7): 1738–1750. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fmcp.M800567-MCP200">10.1074/mcp.M800567-MCP200</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709198">2709198</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19372136">19372136</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+%26+Cellular+Proteomics&rft.atitle=SLP-65+phosphorylation+dynamics+reveals+a+functional+basis+for+signal+integration+by+receptor-proximal+adaptor+proteins&rft.volume=8&rft.issue=7&rft.pages=1738-1750&rft.date=2009-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2709198%23id-name%3DPMC&rft_id=info%3Apmid%2F19372136&rft_id=info%3Adoi%2F10.1074%2Fmcp.M800567-MCP200&rft.aulast=Oellerich&rft.aufirst=T&rft.au=Gr%C3%B8nborg%2C+M&rft.au=Neumann%2C+K&rft.au=Hsiao%2C+HH&rft.au=Urlaub%2C+H&rft.au=Wienands%2C+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2709198&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=B-cell_linker&action=edit&section=5" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMaruyamaSugano1994" class="citation journal cs1">Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". <i>Gene</i>. <b>138</b> (1–2): 171–174. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0378-1119%2894%2990802-8">10.1016/0378-1119(94)90802-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8125298">8125298</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Oligo-capping%3A+a+simple+method+to+replace+the+cap+structure+of+eukaryotic+mRNAs+with+oligoribonucleotides&rft.volume=138&rft.issue=1%E2%80%932&rft.pages=171-174&rft.date=1994-01&rft_id=info%3Adoi%2F10.1016%2F0378-1119%2894%2990802-8&rft_id=info%3Apmid%2F8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFuChan1997" class="citation journal cs1">Fu C, Chan AC (October 1997). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.272.43.27362">"Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation"</a>. <i>The Journal of Biological Chemistry</i>. <b>272</b> (43): 27362–27368. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.272.43.27362">10.1074/jbc.272.43.27362</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9341187">9341187</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Identification+of+two+tyrosine+phosphoproteins%2C+pp70+and+pp68%2C+which+interact+with+phospholipase+Cgamma%2C+Grb2%2C+and+Vav+after+B+cell+antigen+receptor+activation&rft.volume=272&rft.issue=43&rft.pages=27362-27368&rft.date=1997-10&rft_id=info%3Adoi%2F10.1074%2Fjbc.272.43.27362&rft_id=info%3Apmid%2F9341187&rft.aulast=Fu&rft.aufirst=C&rft.au=Chan%2C+AC&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.272.43.27362&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSuzukiYoshitomo-NakagawaMaruyamaSuyama1997" class="citation journal cs1">Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". <i>Gene</i>. <b>200</b> (1–2): 149–156. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0378-1119%2897%2900411-3">10.1016/S0378-1119(97)00411-3</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9373149">9373149</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Construction+and+characterization+of+a+full+length-enriched+and+a+5%27-end-enriched+cDNA+library&rft.volume=200&rft.issue=1%E2%80%932&rft.pages=149-156&rft.date=1997-10&rft_id=info%3Adoi%2F10.1016%2FS0378-1119%2897%2900411-3&rft_id=info%3Apmid%2F9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa%2C+K&rft.au=Maruyama%2C+K&rft.au=Suyama%2C+A&rft.au=Sugano%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWienandsSchweikertWollscheidJumaa1998" class="citation journal cs1">Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M (August 1998). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213353">"SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation"</a>. <i>The Journal of Experimental Medicine</i>. <b>188</b> (4): 791–795. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1084%2Fjem.188.4.791">10.1084/jem.188.4.791</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213353">2213353</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9705962">9705962</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Experimental+Medicine&rft.atitle=SLP-65%3A+a+new+signaling+component+in+B+lymphocytes+which+requires+expression+of+the+antigen+receptor+for+phosphorylation&rft.volume=188&rft.issue=4&rft.pages=791-795&rft.date=1998-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2213353%23id-name%3DPMC&rft_id=info%3Apmid%2F9705962&rft_id=info%3Adoi%2F10.1084%2Fjem.188.4.791&rft.aulast=Wienands&rft.aufirst=J&rft.au=Schweikert%2C+J&rft.au=Wollscheid%2C+B&rft.au=Jumaa%2C+H&rft.au=Nielsen%2C+PJ&rft.au=Reth%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2213353&rfr_id=info%3Asid%2Fen.wikipedia.org%3AB-cell+linker" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHashimotoIwamatsuIshiaiOkawa1999" class="citation journal cs1">Hashimoto S, Iwamatsu A, Ishiai M, Okawa K, Yamadori T, Matsushita M, et al. 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