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class="mw-page-title-main">PLCG2</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">PLCG2</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_PLCG2_PDB_2K2J.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Protein_PLCG2_PDB_2K2J.png/250px-Protein_PLCG2_PDB_2K2J.png" decoding="async" width="250" height="208" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Protein_PLCG2_PDB_2K2J.png/375px-Protein_PLCG2_PDB_2K2J.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Protein_PLCG2_PDB_2K2J.png/500px-Protein_PLCG2_PDB_2K2J.png 2x" data-file-width="1200" data-file-height="1000" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q8CIH5%20or%20P16885">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q8CIH5,P16885">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2K2J">2K2J</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2W2W">2W2W</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2W2X">2W2X</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/9066">PLCG2</a></span>, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 2</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/600220">600220</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:97616">97616</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=55671">55671</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=PLCG2">PLCG2</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000197943">PLCG2 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_16.svg" class="mw-file-description" title="Chromosome 16 (human)"><img alt="Chromosome 16 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/300px-Ideogram_human_chromosome_16.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/450px-Ideogram_human_chromosome_16.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/600px-Ideogram_human_chromosome_16.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_16_(human)" class="mw-redirect" title="Chromosome 16 (human)">Chromosome 16 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_16_ideogram.svg" class="mw-file-description" title="Chromosome 16 (human)"><img alt="Chromosome 16 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/300px-Human_chromosome_16_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/450px-Human_chromosome_16_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Human_chromosome_16_ideogram.svg/600px-Human_chromosome_16_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 261.09884379309px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for PLCG2"><img alt="Genomic location for PLCG2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 267.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for PLCG2"><img alt="Genomic location for PLCG2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">16q23.3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">81,739,097 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">81,962,685 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_8.svg" class="mw-file-description" title="Chromosome 8 (mouse)"><img alt="Chromosome 8 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/260px-Ideogram_house_mouse_chromosome_8.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/390px-Ideogram_house_mouse_chromosome_8.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/520px-Ideogram_house_mouse_chromosome_8.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 8 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_8.svg" class="mw-file-description" title="Chromosome 8 (mouse)"><img alt="Chromosome 8 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/300px-Ideogram_of_house_mouse_chromosome_8.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/450px-Ideogram_of_house_mouse_chromosome_8.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/46/Ideogram_of_house_mouse_chromosome_8.svg/600px-Ideogram_of_house_mouse_chromosome_8.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 263.48490299757px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for PLCG2"><img alt="Genomic location for PLCG2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 269.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for PLCG2"><img alt="Genomic location for PLCG2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">8 E1|8 64.26 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">118,225,030 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">118,361,881 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000197943">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">glomerulus</li><br /><li style="line-height: 137%;">bone marrow cells</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">metanephric glomerulus</li><br /><li style="line-height: 137%;">epithelium of nasopharynx</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">endothelial cell</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">kidney tubule</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000034330">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">basilar part of occipital bone</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">tibiofemoral joint</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">bone marrow</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">sphenoid bone</li><br /><li style="line-height: 137%;">external carotid artery</li><br /><li style="line-height: 137%;">internal carotid artery</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000197943">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_PLCG2_204613_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/PBB_GE_PLCG2_204613_at_fs.png/250px-PBB_GE_PLCG2_204613_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/PBB_GE_PLCG2_204613_at_fs.png/375px-PBB_GE_PLCG2_204613_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/PBB_GE_PLCG2_204613_at_fs.png/500px-PBB_GE_PLCG2_204613_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/5336/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/">signal transducer activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008081">phosphoric diester hydrolase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004629">phospholipase C activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016787">hydrolase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004435">phosphatidylinositol phospholipase C activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001784">phosphotyrosine residue binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070062">extracellular exosome</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050853">B cell receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051209">release of sequestered calcium ion into cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035556">intracellular signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032959">inositol trisphosphate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038096">Fc-gamma receptor signaling pathway involved in phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002092">positive regulation of receptor internalization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006629">lipid metabolism</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002223">stimulatory C-type lectin receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043647">inositol phosphate metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016055">Wnt signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030168">platelet activation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038095">Fc-epsilon receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016042">lipid catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002316">follicular B cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032496">response to lipopolysaccharide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009395">phospholipid catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010468">regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006661">phosphatidylinositol biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043069">negative regulation of programmed cell death</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030183">B cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050852">T cell receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032237">activation of store-operated calcium channel activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032481">positive regulation of type I interferon production</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019722">calcium-mediated signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048015">phosphatidylinositol-mediated signaling</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=5336&rn=1">5336</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=234779&rn=1">234779</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000197943;db=core">ENSG00000197943</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000034330;db=core">ENSMUSG00000034330</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P16885">P16885</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q8CIH5">Q8CIH5</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_002661">NM_002661</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_172285">NM_172285</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_002652">NP_002652</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_758489">NP_758489</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr16:81739097-81962685">Chr 16: 81.74 – 81.96 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr8:118225030-118361881">Chr 8: 118.23 – 118.36 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18030586" class="extiw" title="d:Q18030586">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q18298372" class="extiw" title="d:Q18298372">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2</b> is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>PLCG2</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid7835906_5-0" class="reference"><a href="#cite_note-pmid7835906-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_6-0" class="reference"><a href="#cite_note-entrez-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PLCG2&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>From <a href="/wiki/OMIM" class="mw-redirect" title="OMIM">OMIM</a> as of March 24, 2020:<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <blockquote> <p>Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3. </p> </blockquote> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PLCG2&action=edit&section=2" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PLCG2 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <ul><li><a href="/wiki/Bruton%27s_tyrosine_kinase" title="Bruton's tyrosine kinase">Bruton's tyrosine kinase</a>,<sup id="cite_ref-pmid10981967_8-0" class="reference"><a href="#cite_note-pmid10981967-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12093870_9-0" class="reference"><a href="#cite_note-pmid12093870-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GAB2" title="GAB2">GAB2</a>,<sup id="cite_ref-pmid12135708_10-0" class="reference"><a href="#cite_note-pmid12135708-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/LYN" title="LYN">LYN</a>,<sup id="cite_ref-pmid10981967_8-1" class="reference"><a href="#cite_note-pmid10981967-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8395016_11-0" class="reference"><a href="#cite_note-pmid8395016-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PTPN11" title="PTPN11">PTPN11</a>,<sup id="cite_ref-pmid12135708_10-1" class="reference"><a href="#cite_note-pmid12135708-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/SHC1" title="SHC1">SHC1</a><sup id="cite_ref-pmid12135708_10-2" class="reference"><a href="#cite_note-pmid12135708-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10623845_12-0" class="reference"><a href="#cite_note-pmid10623845-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PLCG2&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist 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Biol</i>. <b>13</b> (9): 5877–87. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.13.9.5877">10.1128/MCB.13.9.5877</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC360336">360336</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8395016">8395016</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol.+Cell.+Biol.&rft.atitle=Mapping+of+sites+on+the+Src+family+protein+tyrosine+kinases+p55blk%2C+p59fyn%2C+and+p56lyn+which+interact+with+the+effector+molecules+phospholipase+C-gamma+2%2C+microtubule-associated+protein+kinase%2C+GTPase-activating+protein%2C+and+phosphatidylinositol+3-kinase&rft.volume=13&rft.issue=9&rft.pages=5877-87&rft.date=1993-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC360336%23id-name%3DPMC&rft_id=info%3Apmid%2F8395016&rft_id=info%3Adoi%2F10.1128%2FMCB.13.9.5877&rft.aulast=Pleiman&rft.aufirst=CM&rft.au=Clark%2C+MR&rft.au=Gauen%2C+LK&rft.au=Winitz%2C+S&rft.au=Coggeshall%2C+KM&rft.au=Johnson%2C+GL&rft.au=Shaw%2C+AS&rft.au=Cambier%2C+JC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC360336&rfr_id=info%3Asid%2Fen.wikipedia.org%3APLCG2" class="Z3988"></span></span> </li> <li id="cite_note-pmid10623845-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10623845_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPerskvistZhengStendahl2000" class="citation journal cs1">Perskvist N, Zheng L, Stendahl O (January 2000). 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Immunol</i>. <b>164</b> (2): 959–65. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4049%2Fjimmunol.164.2.959">10.4049/jimmunol.164.2.959</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10623845">10623845</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19134463">19134463</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Immunol.&rft.atitle=Activation+of+human+neutrophils+by+Mycobacterium+tuberculosis+H37Ra+involves+phospholipase+C+gamma+2%2C+Shc+adapter+protein%2C+and+p38+mitogen-activated+protein+kinase&rft.volume=164&rft.issue=2&rft.pages=959-65&rft.date=2000-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A19134463%23id-name%3DS2CID&rft_id=info%3Apmid%2F10623845&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.164.2.959&rft.aulast=Perskvist&rft.aufirst=N&rft.au=Zheng%2C+L&rft.au=Stendahl%2C+O&rfr_id=info%3Asid%2Fen.wikipedia.org%3APLCG2" class="Z3988"></span></span> </li> </ol></div></div> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=PLCG2&action=edit&section=4" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFrumanSatterthwaiteWitte2000" class="citation journal cs1">Fruman DA, Satterthwaite AB, Witte ON (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2800%2900002-9">"Xid-like phenotypes: a B cell signalosome takes shape"</a>. <i>Immunity</i>. <b>13</b> (1): 1–3. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1074-7613%2800%2900002-9">10.1016/S1074-7613(00)00002-9</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10933389">10933389</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Immunity&rft.atitle=Xid-like+phenotypes%3A+a+B+cell+signalosome+takes+shape&rft.volume=13&rft.issue=1&rft.pages=1-3&rft.date=2000&rft_id=info%3Adoi%2F10.1016%2FS1074-7613%2800%2900002-9&rft_id=info%3Apmid%2F10933389&rft.aulast=Fruman&rft.aufirst=DA&rft.au=Satterthwaite%2C+AB&rft.au=Witte%2C+ON&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS1074-7613%252800%252900002-9&rfr_id=info%3Asid%2Fen.wikipedia.org%3APLCG2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCefaiDebreKaczorekIdziorek1990" class="citation journal cs1">Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329852">"Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway"</a>. <i>J. 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hydrolases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a> <ul><li><a href="/wiki/Acetylcholinesterase" title="Acetylcholinesterase">Acetylcholinesterase</a></li> <li><a href="/wiki/Butyrylcholinesterase" title="Butyrylcholinesterase">Butyrylcholinesterase</a></li></ul></li> <li><a href="/wiki/Pectinesterase" title="Pectinesterase">Pectinesterase</a></li> <li><a href="/wiki/6-phosphogluconolactonase" title="6-phosphogluconolactonase">6-phosphogluconolactonase</a></li> <li><a href="/wiki/PAF_acetylhydrolase" class="mw-redirect" title="PAF acetylhydrolase">PAF acetylhydrolase</a></li></ul> <ul><li><a href="/wiki/Lipase" title="Lipase">Lipase</a> <ul><li><a href="/wiki/Bile_salt-dependent_lipase" title="Bile salt-dependent lipase">Bile salt-dependent</a></li> <li><a href="/wiki/Gastric_lipase" title="Gastric lipase">Gastric</a>/<a href="/wiki/Lingual_lipase" title="Lingual lipase">Lingual</a></li> <li><a href="/wiki/Pancreatic_lipase" class="mw-redirect" title="Pancreatic lipase">Pancreatic</a></li> <li><a href="/wiki/Lysosomal_lipase" title="Lysosomal lipase">Lysosomal</a></li> <li><a href="/wiki/Hormone-sensitive_lipase" title="Hormone-sensitive lipase">Hormone-sensitive</a></li> <li><a href="/wiki/Endothelial_lipase" title="Endothelial lipase">Endothelial</a></li> <li><a href="/wiki/Hepatic_lipase" title="Hepatic lipase">Hepatic</a></li> <li><a href="/wiki/Lipoprotein_lipase" title="Lipoprotein lipase">Lipoprotein</a></li> <li><a href="/wiki/Monoacylglycerol_lipase" title="Monoacylglycerol lipase">Monoacylglycerol</a></li> <li><a href="/wiki/Diacylglycerol_lipase" title="Diacylglycerol lipase">Diacylglycerol</a></li></ul></li></ul> <ul><li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_A1" title="Phospholipase A1">A1</a></li> <li><a href="/wiki/Phospholipase_A2" title="Phospholipase A2">A2</a></li> <li><a href="/wiki/Phospholipase_B" title="Phospholipase B">B</a></li></ul></li></ul> <ul><li><a href="/wiki/Cutinase" title="Cutinase">Cutinase</a></li> <li><a href="/wiki/PETase" title="PETase">PETase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.2:_Thioester_Hydrolases" title="List of EC numbers (EC 3)">3.1.2</a>: <a href="/wiki/Thioesterase" title="Thioesterase">Thioesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Palmitoyl_protein_thioesterase" class="mw-redirect" title="Palmitoyl protein thioesterase">Palmitoyl protein thioesterase</a></li> <li><a href="/wiki/Ubiquitin_carboxy-terminal_hydrolase_L1" title="Ubiquitin carboxy-terminal hydrolase L1">Ubiquitin carboxy-terminal hydrolase L1</a></li> <li><a href="/wiki/4-hydroxybenzoyl-CoA_thioesterase" title="4-hydroxybenzoyl-CoA thioesterase">4-hydroxybenzoyl-CoA thioesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.3:_Phosphoric_Monoester_Hydrolases" title="List of EC numbers (EC 3)">3.1.3</a>: <a href="/wiki/Phosphatase" title="Phosphatase">Phosphatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alkaline_phosphatase" title="Alkaline phosphatase">Alkaline phosphatase</a> <ul><li><a href="/wiki/ALPI" title="ALPI">ALPI</a></li> <li><a href="/wiki/ALPL" title="ALPL">ALPL</a></li> <li><a href="/wiki/Placental_alkaline_phosphatase" class="mw-redirect" title="Placental alkaline phosphatase">ALPP</a></li></ul></li> <li><a href="/wiki/Acid_phosphatase" title="Acid phosphatase">Acid phosphatase</a> (<a href="/wiki/Prostatic_acid_phosphatase" title="Prostatic acid phosphatase">Prostatic</a>)/<a href="/wiki/Tartrate-resistant_acid_phosphatase" title="Tartrate-resistant acid phosphatase">Tartrate-resistant acid phosphatase</a>/<a href="/wiki/Purple_acid_phosphatases" title="Purple acid phosphatases">Purple acid phosphatases</a></li> <li><a href="/wiki/Nucleotidase" title="Nucleotidase">Nucleotidase</a></li> <li><a href="/wiki/Glucose_6-phosphatase" title="Glucose 6-phosphatase">Glucose 6-phosphatase</a></li> <li><a href="/wiki/Fructose_1,6-bisphosphatase" title="Fructose 1,6-bisphosphatase">Fructose 1,6-bisphosphatase</a> <ul><li><a href="/wiki/Calcineurin" title="Calcineurin">Calcineurin</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a> <ul><li><a href="/wiki/PP2A" class="mw-redirect" title="PP2A">PP2A</a></li></ul></li> <li><a href="/wiki/OCRL" title="OCRL">OCRL</a></li> <li><a href="/wiki/Pyruvate_dehydrogenase_phosphatase" title="Pyruvate dehydrogenase phosphatase">Pyruvate dehydrogenase phosphatase</a></li> <li><a href="/wiki/Phosphofructokinase_2" title="Phosphofructokinase 2">Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase</a></li> <li><a href="/wiki/PTEN_(gene)" title="PTEN (gene)">PTEN</a></li> <li><a href="/wiki/Phytase" title="Phytase">Phytase</a> <ul><li><a href="/wiki/Beta-propeller_phytase" title="Beta-propeller phytase">Beta-propeller phytase</a></li></ul></li> <li><a href="/wiki/Inositol-phosphate_phosphatase" title="Inositol-phosphate phosphatase">Inositol-phosphate phosphatase</a> <ul><li><a href="/wiki/Inositol_monophosphatase_1" title="Inositol monophosphatase 1">IMPA1</a>, <a href="/wiki/Inositol_monophosphatase_2" title="Inositol monophosphatase 2">IMPA2</a>, <a href="/wiki/Inositol_monophosphatase_3" title="Inositol monophosphatase 3">IMPA3</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a>: <a href="/wiki/Protein_tyrosine_phosphatase" title="Protein tyrosine phosphatase">Protein tyrosine phosphatase</a></li> <li><a href="/wiki/Protein_serine/threonine_phosphatase" title="Protein serine/threonine phosphatase">Protein serine/threonine phosphatase</a></li> <li><a href="/wiki/Dual-specificity_phosphatase" title="Dual-specificity phosphatase">Dual-specificity phosphatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.4:_Phosphoric_Diester_Hydrolases" title="List of EC numbers (EC 3)">3.1.4</a>:<br /><a href="/wiki/Phosphodiesterase" title="Phosphodiesterase">Phosphodiesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autotaxin" title="Autotaxin">Autotaxin</a></li> <li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_C" title="Phospholipase C">C</a></li> <li><a href="/wiki/Phospholipase_D" title="Phospholipase D">D</a></li></ul></li> <li><a href="/wiki/Sphingomyelin_phosphodiesterase" title="Sphingomyelin phosphodiesterase">Sphingomyelin phosphodiesterase</a> <ul><li><a href="/wiki/Sphingomyelin_phosphodiesterase_1" title="Sphingomyelin phosphodiesterase 1">1</a></li></ul></li> <li><a href="/wiki/PDE1" title="PDE1">PDE1</a></li> <li><a href="/wiki/Phosphodiesterase_2" title="Phosphodiesterase 2">PDE2</a></li> <li><a href="/wiki/Phosphodiesterase_3" title="Phosphodiesterase 3">PDE3</a></li> <li><a href="/wiki/PDE4A" title="PDE4A">PDE4A</a>/<a href="/wiki/PDE4B" title="PDE4B">PDE4B</a></li> <li><a href="/wiki/CGMP-specific_phosphodiesterase_type_5" title="CGMP-specific phosphodiesterase type 5">PDE5</a></li> <li><a href="/wiki/Lecithinase" title="Lecithinase">Lecithinase</a> (<a href="/wiki/Clostridium_perfringens_alpha_toxin" title="Clostridium perfringens alpha toxin">Clostridium perfringens alpha toxin</a>)</li> <li><a href="/wiki/Cyclic_nucleotide_phosphodiesterase" title="Cyclic nucleotide phosphodiesterase">Cyclic nucleotide phosphodiesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.6:_Sulfuric_Ester_Hydrolases" title="List of EC numbers (EC 3)">3.1.6</a>: <a href="/wiki/Sulfatase" title="Sulfatase">Sulfatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Arylsulfatase" title="Arylsulfatase">arylsulfatase</a></i> <ul><li><a href="/wiki/Arylsulfatase_A" title="Arylsulfatase A">Arylsulfatase A</a></li> <li><a href="/wiki/Arylsulfatase_B" title="Arylsulfatase B">Arylsulfatase B</a></li> <li><a href="/wiki/Arylsulfatase_L" title="Arylsulfatase L">Arylsulfatase L</a></li> <li><a href="/wiki/Steroid_sulfatase" title="Steroid sulfatase">Steroid sulfatase</a></li></ul></li> <li><a href="/wiki/Galactosamine-6_sulfatase" title="Galactosamine-6 sulfatase">Galactosamine-6 sulfatase</a></li> <li><a href="/wiki/Iduronate-2-sulfatase" title="Iduronate-2-sulfatase">Iduronate-2-sulfatase</a></li> <li><a href="/wiki/N-acetylglucosamine-6-sulfatase" title="N-acetylglucosamine-6-sulfatase">N-acetylglucosamine-6-sulfatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nuclease" title="Nuclease">Nuclease</a> (includes<br /><a href="/wiki/Deoxyribonuclease" title="Deoxyribonuclease">deoxyribonuclease</a><br />and <a href="/wiki/Ribonuclease" title="Ribonuclease">ribonuclease</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.11:_Exodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.11</a>-16:<br /><a href="/wiki/Exonuclease" title="Exonuclease">Exonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exodeoxyribonuclease" title="Exodeoxyribonuclease">Exodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RecBCD" title="RecBCD">RecBCD</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exoribonuclease" title="Exoribonuclease">Exoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oligonucleotidase" title="Oligonucleotidase">Oligonucleotidase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.21:_Endodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.21</a>-31:<br /><a href="/wiki/Endonuclease" title="Endonuclease">Endonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endodeoxyribonuclease" title="Endodeoxyribonuclease">Endodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Deoxyribonuclease_I" title="Deoxyribonuclease I">Deoxyribonuclease I</a></li> <li><a href="/wiki/Deoxyribonuclease_II" title="Deoxyribonuclease II">Deoxyribonuclease II</a></li> <li><a href="/wiki/Deoxyribonuclease_IV" title="Deoxyribonuclease IV">Deoxyribonuclease IV</a></li> <li><a href="/wiki/Restriction_enzyme" title="Restriction enzyme">Restriction enzyme</a>;see <span class="nowrap">{{</span><a href="/wiki/Template:Restriction_enzyme" title="Template:Restriction enzyme">Restriction enzyme</a><span class="nowrap">}}</span></li> <li><a href="/wiki/UvrABC_endonuclease" title="UvrABC endonuclease">UvrABC endonuclease</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endoribonuclease" title="Endoribonuclease">Endoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RNase_III" class="mw-redirect" title="RNase III">RNase III</a> <ul><li><a href="/wiki/Drosha" title="Drosha">Drosha</a>: <a href="/wiki/Microprocessor_complex" title="Microprocessor complex">Microprocessor complex</a></li> <li><a href="/wiki/Dicer" title="Dicer">Dicer</a>: <a href="/wiki/RNA-induced_silencing_complex" title="RNA-induced silencing complex">RNA-induced silencing complex</a></li></ul></li> <li><a href="/wiki/RNase_H" class="mw-redirect" title="RNase H">RNase H</a> <ul><li><a href="/wiki/RNASEH1" title="RNASEH1">1</a></li> <li><a href="/wiki/RNASEH2A" title="RNASEH2A">2A</a></li> <li><a href="/wiki/RNASEH2B" title="RNASEH2B">2B</a></li> <li><a href="/wiki/RNASEH2C" title="RNASEH2C">2C</a></li></ul></li> <li><a href="/wiki/RNase_P" class="mw-redirect" title="RNase P">RNase P</a></li> <li><a href="/wiki/Ribonuclease_A" class="mw-redirect" title="Ribonuclease A">RNase A</a></li> <li><a href="/wiki/Ribonuclease_Z" title="Ribonuclease Z">RNase Z</a></li> <li><a href="/wiki/Ribonuclease_E" title="Ribonuclease E">RNase E</a> <ul><li><a href="/wiki/RNASE1" title="RNASE1">1</a></li> <li><a href="/wiki/Eosinophil-derived_neurotoxin" title="Eosinophil-derived neurotoxin">2</a></li> <li><a href="/wiki/Eosinophil_cationic_protein" title="Eosinophil cationic protein">3</a></li> <li><a href="/wiki/Angiogenin" title="Angiogenin">4/5</a></li></ul></li> <li><a href="/wiki/Ribonuclease_T1" title="Ribonuclease T1">RNase T1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">either deoxy- or ribo-    </th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclease_S1" title="Nuclease S1">Nuclease S1</a> <ul><li><a href="/wiki/Mung_bean_nuclease" title="Mung bean nuclease">Mung bean nuclease</a></li></ul></li> <li><a href="/wiki/Serratia_marcescens_nuclease" title="Serratia marcescens nuclease">Serratia marcescens nuclease</a></li> <li><a href="/wiki/Micrococcal_nuclease" title="Micrococcal nuclease">Micrococcal nuclease</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output 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