Research & Technology

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--background-color:#01210e;--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;--overlay:;"> <div class="hero__container"> <figure class="hero-background block_background background_type_image has_overlay bg_fill_dt_cover block_background__media " style="--background-color:#01210e;--bg-position-x-dt:center;--bg-position-y-dt:center;--bg-position-x-mb:center;--bg-position-y-mb:center;--overlay:; "><picture><source media="(max-width:767px)" data-srcset="https://www.calicolabs.com/wp-content/uploads/2020/05/researchtech_hero_img_mobile@2x.jpg"><img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2020/05/researchtech_hero_desktop@2x-1024x639.jpg" data-srcset="https://www.calicolabs.com/wp-content/uploads/2020/05/researchtech_hero_desktop@2x-1024x639.jpg 1024w, https://www.calicolabs.com/wp-content/uploads/2020/05/researchtech_hero_desktop@2x-300x187.jpg 300w, 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https://www.calicolabs.com/wp-content/uploads/2020/05/researchtech_hero_desktop@2x-1536x958.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2020/05/researchtech_hero_desktop@2x-2048x1277.jpg 2048w" sizes="(max-width:2000px) 100vw, 2000px" alt=""/></noscript></picture></figure> <div class="hero__heading "> <div class="hero__heading__container"> <div class="hero__heading__title"> <h1 class="h1"> Understanding the biology of aging and longevity </h1 > </div> <div class="hero__heading__description"> <p>We are working to answer the most challenging biological questions of our time — how do humans age and how can we develop interventions to enable people to live longer, healthier lives.</p> </div> </div> </div> <div class="hero__scroll__container"> <div class="hero__scroll"> <a href=""> <svg height="39" viewBox="0 0 39 39" width="39" class=""> <g> <g id="scroll-icon-arrow"> <rect y="-40" fill="none" stroke="none" width="40" height="80"></rect> <path d="M27.5,19.5c-0.3-0.3-0.8-0.3-1.1,0l-5.7,5.7V13c0-0.4-0.3-0.8-0.8-0.8s-0.8,0.3-0.8,0.8v12.2l-5.7-5.7 c-0.3-0.3-0.8-0.3-1.1,0s-0.3,0.8,0,1.1l7,7c0.1,0.1,0.2,0.1,0.2,0.2c0.1,0,0.2,0.1,0.3,0.1s0.2,0,0.3-0.1c0.1,0,0.2-0.1,0.2-0.2 l7-7C27.8,20.2,27.8,19.8,27.5,19.5z"> </path> <path d="M27.5-20.5c-0.3-0.3-0.8-0.3-1.1,0l-5.7,5.7V-27c0-0.4-0.3-0.8-0.8-0.8s-0.8,0.3-0.8,0.8v12.2l-5.7-5.7 c-0.3-0.3-0.8-0.3-1.1,0s-0.3,0.8,0,1.1l7,7c0.1,0.1,0.2,0.1,0.2,0.2c0.1,0,0.2,0.1,0.3,0.1s0.2,0,0.3-0.1c0.1,0,0.2-0.1,0.2-0.2 l7-7C27.8-19.8,27.8-20.2,27.5-20.5z"> </path> </g>  </g> </svg> </a> <div class="hero__scroll__line"></div> </div> </div> </div> </div> <section id="page_section_block_adbd221310205a2cb999fa47db8840b9" class="page-section mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default block_background background_type_color " style=""> <div class="acf-innerblocks-container"> <div id="sizing_container_block_f17011e2cc51d06ef80ddf7c149f7e1e" class="sizing-container section__margin_auto container__small mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h4 id="heading_block_c21dab1d482ca12cf01172ecab62693d" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default eyebrow align-left align-left-mobile"> Approach </h4> <h2 id="heading_block_e321e005361ca37754446fcc1f529242" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Since our founding, Calico’s approach to understanding the biology of aging and age-related diseases has remained the foundation of our efforts </h2> <section id="grid_container_block_62f1e2e79da928176679836b69fb336c" class="grid-container section__margin_auto mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default container__default cols-2-dt cg-4-dt rg-4-dt align-top-dt justify-left-dt cols-1-mb cg-1-mb rg-1-mb align-top-mb justify-left-mb uses-mb-settings" style="" data-cols-dt="2" data-cols-mb="1"> <div class="grid-container_wrapper"> <section id="grid_container_block_d5c60bf11311b824db46885477a778df" class="grid-container section__margin_auto mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default container__default cols-1-dt cg-1-dt rg-4-dt align-top-dt justify-left-dt" style="" data-cols-dt="1"> <div class="grid-container_wrapper"> <div id="sizing_container_block_997fc4366fcef7db724d021168c10045" class="sizing-container section__margin_auto container__default mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default from-bottom__0 has_decorative_border top_border_border_top_light" style=""> <div class="sizing-container_wrapper"> <p>Focusing on both basic research and the translation of our discoveries into new interventions that may help people live healthier, and longer lives</p> </div> </div> <div id="sizing_container_block_997fc4366fcef7db724d021168c10045" class="sizing-container section__margin_auto container__default mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default from-bottom__0 has_decorative_border top_border_border_top_light" style=""> <div class="sizing-container_wrapper"> <p>Working at the convergence of biology and technology, coupled with a long-term perspective and funding</p> </div> </div> <div id="sizing_container_block_997fc4366fcef7db724d021168c10045" class="sizing-container section__margin_auto container__default mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default from-bottom__0 has_decorative_border top_border_border_top_light" style=""> <div class="sizing-container_wrapper"> <p>Collaborating with external organizations, including other biopharmaceutical companies and academic institutions, to combine our efforts</p> </div> </div> </div> </section> <section id="grid_container_block_d5c60bf11311b824db46885477a778df" class="grid-container section__margin_auto mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default container__default cols-1-dt cg-1-dt rg-4-dt align-top-dt justify-left-dt" style="" data-cols-dt="1"> <div class="grid-container_wrapper"> <div id="sizing_container_block_997fc4366fcef7db724d021168c10045" class="sizing-container section__margin_auto container__default mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default from-bottom__0 has_decorative_border top_border_border_top_light" style=""> <div class="sizing-container_wrapper"> <p>Taking a long-term approach, understanding that breakthroughs are made possible through persistent efforts over time</p> </div> </div> <div id="sizing_container_block_997fc4366fcef7db724d021168c10045" class="sizing-container section__margin_auto container__default mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default from-bottom__0 has_decorative_border top_border_border_top_light" style=""> <div class="sizing-container_wrapper"> <p>Employing an interdisciplinary approach, harnessing advanced technologies and computing, to accelerate discoveries. Inventing new methods when existing technology and approaches do not meet our needs</p> </div> </div> </div> </section> </div> </section> </div> </div> <div id="sizing_container_block_bd91c7fddba75af270c0d4d440c5ca8e" class="sizing-container section__margin_auto container__large mt-7 mb-3 pt-default pb-default mobile-mt-5 mobile-mb-3 mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <div class="featuredCard mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default " id="featured_card_block_6ec6a69edbefcb48e000654ff01903a7" style=" "> <div class="featuredCard post-4202 lab_story type-lab_story status-publish has-post-thumbnail hentry category-technology from-bottom__0"> <div class="featuredCard__container">  <div class="featuredCard__ribbon from-bottom__0"> <p class="t-label-small"> Calico Stories </p> </div>  <div class="featuredCard__heading"> <div class="featuredCard__heading-container">   <div class="featuredCard__date from-bottom__0"> <span> June 27, 2024 </span> </div>  <div class="featuredCard__title from-bottom__0"> <h4> <a href="https://www.calicolabs.com/story/mapping-the-mechanisms-of-aging/" target="_self"> Mapping the Mechanisms of Aging </a> </h4> </div>  <p class="featuredCard__description t-body-large from-bottom__0"> Aging is a universal experience, evident through changes like wrinkles and graying hair. However, aging goes beyond the surface; it begins within our cells. Over time, our cells… </p>  </div>  <div class="featuredCard__buttons from-bottom__0"> <div class="primary-button"> <a id="4202" class="btn btn__outlined white " style="" href="https://www.calicolabs.com/story/mapping-the-mechanisms-of-aging/" target="_self">Keep Reading</a> </div> <div class="secondary-button"> <a id="4202" class="btn btn__simple white " style="" href="https://www.calicolabs.com/calico-stories/" target="_self">See More Stories</a> </div> </div> </div>  <figure class="featuredCard__img"> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-2000x1125.png" data-srcset="https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-2000x1125.png 2000w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-1200x675.png 1200w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-768x432.png 768w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-1536x864.png 1536w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-2048x1152.png 2048w" data-sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="" width="" height="" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2000px; --smush-placeholder-aspect-ratio: 2000/1125;"><noscript><img decoding="async" class="" src="https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-2000x1125.png" srcset="https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-2000x1125.png 2000w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-1200x675.png 1200w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-768x432.png 768w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-1536x864.png 1536w, https://www.calicolabs.com/wp-content/uploads/2024/06/c.elegans-umap-2048x1152.png 2048w" sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="" width="" height="" loading="lazy"></noscript> </figure> </div> </div> </div> </div> </div> <div id="sizing_container_block_f17011e2cc51d06ef80ddf7c149f7e1e" class="sizing-container section__margin_auto container__small mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h4 id="heading_block_6cae43276b1ffee0eb74ec0c2a1da180" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default eyebrow align-left align-left-mobile"> Basic research </h4> <h2 id="heading_block_822836cd91c68cc7a1dfd00090d0f3c3" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> We hire innovative scientists with a broad range of skills and experiences and encourage them to collaborate freely </h2> <p>Our Research group features <strong>Principal Investigator-led labs</strong> working to understand the biological pathways of aging and disease — efforts that are accelerated by advanced computing and technology that are at or beyond the state-of-the art.</p> <ul class="table_list mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default label-font-size-auto content-font-size-" id="table_listblock_2cdd494503d98df8ca7ca9d502abb2e9" style=""> <li class="table_list__item from-bottom__0"> <div class="table_list__heading"> <span>Small labs, big collaboration</span> </div> <div class="table_list__content"> <p>Our research efforts are designed to fuel intellectual freedom and creativity. Ours is a bottom-up approach. Labs at Calico are small and we encourage collaboration and interdisciplinary research at every turn.</p> </div> </li> <li class="table_list__item from-bottom__0"> <div class="table_list__heading"> <span>Biology that matters</span> </div> <div class="table_list__content"> <p>Scientists in our basic research labs are working to understand how experimental organisms age by observing the aging process at the levels of the whole organism, organs and tissues and individual cells. Through these research efforts, Calico scientists work to understand the biological underpinnings of aging by studying organisms such as yeast, <i>C. elegans</i> (worms), mice, and human cells and tissues. And our researchers, especially our computational biologists, are digging deep into large available human genetic data sets to inform both our research and our translational efforts.</p> <p><a href="https://www.calicolabs.com/publications">Our publications provide rich details about our research</a></p> </div> </li> </ul> </div> </div> <div id="sizing_container_block_32676d15ecb51ba02ff2228d042cccff" class="sizing-container section__margin_auto container__default mt-6 mb-6 pt-2 pb-default mobile-mt-3 mobile-mb-1 mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <figure class="media_block from-bottom__0 no_aspect_ratio mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default media_type_image alignment_dt_left alignment_mb_left size_dt_auto size_mb_auto" id="media_block_block_faa372f2d9bc47a0b89b842adf7dcc61" style=""> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2024/07/0S5A11625-4-2000x1137.jpg" srcset="" data-sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="" width="1894" height="1160" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 1894px; --smush-placeholder-aspect-ratio: 1894/1160;"><noscript><img decoding="async" class="" src="https://www.calicolabs.com/wp-content/uploads/2024/07/0S5A11625-4-2000x1137.jpg" srcset="" sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="" width="1894" height="1160" loading="lazy"></noscript> </figure> </div> </div> <div id="sizing_container_block_f17011e2cc51d06ef80ddf7c149f7e1e" class="sizing-container section__margin_auto container__small mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h4 id="heading_block_5812a643d96d74ab832f182e18eb4b26" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default eyebrow align-left align-left-mobile"> Technology </h4> <h2 id="heading_block_a04e5be32da85a23a98ffbb373dc3f4b" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Our research is powered by technology </h2> <p>We like to think of it as beyond state-of-the-art. At Calico, our technology labs work hand-in-hand with scientists throughout the company, advancing hypotheses on how specific technologies and know-how can help answer a research question or advance a clinical study at the depth required to progress the field.</p> <p>If an existing technology does not help us answer a research question, then we’ll invent something new. Or, we may invent a new technique that enables researchers to take completely different approaches. Scientists and engineers in our technology labs are not bound by the questions of others. They come up with their own approaches enabling scientists to ask big questions, and are encouraged to build and harness new technologies and tools that can support the entire scientific community.</p> <p class="has-gray-800-color has-text-color"><a href="https://www.calicolabs.com/story/power-couple-ai-together-with-cryo-em-reveals-new-insights-into-age-related-protein"><strong>See how two scientists in our microscopy lab invented a new microscope.</strong></a></p> </div> </div> </div> </section> <section id="page_section_block_68cf8dc3421525764d90fb913f7c8b65" class="page-section mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default block_background background_type_color sbg_top sbg_top_dt_custom sbg_top_mb_custom sbg_top_above" style="--background-color:#f5f4f5;--sbg-top-size-dt:150px;--sbg-top-size-mb:150px;--sbg-top-color:#ffffff;"> <div class="acf-innerblocks-container"> <div class="card_slider mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" id="card_sliderblock_07fad108ae1b737939745d3c2bebe748"> <div class="card_slider__inner"> <div class="card_slide"> <div class="card_slide__inner from-bottom__0"> <div class="card_slide__label"><span class="h3">Au</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Automation</span> <p>Building customized robots to perform tasks efficiently and fast</p> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__1"> <div class="card_slide__label"><span class="h3">Bc</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Biochemistry</span> <p>Purification and characterization of recombinant and native proteins</p> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__2"> <div class="card_slide__label"><span class="h3">Fc</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Flow Cytometry</span> <p>Techniques for multiparameter characterization and sorting of cells</p> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__3"> <div class="card_slide__label"><span class="h3">Ge</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Genomics</span> <div class="BlockSlider__ListItem-sc-1ph9zyl-4 hRWlMa aos-init aos-animate" data-aos="fade-up" data-aos-delay="300"> <div class="BlockSlider__ListItemContainer-sc-1ph9zyl-6 gsHLpX"> <p class="Text__Small-sc-1fxfdhx-7 BlockSlider__ListItemLabel-sc-1ph9zyl-5 jfMrXs">Using advanced genomic technologies to create high quality nucleic acid data</p> </div> </div> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__4"> <div class="card_slide__label"><span class="h3">Ms</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Mass Spectrometry</span> <p>Systems-level analysis of proteins, post-translational modifications, lipids and metabolites</p> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__5"> <div class="card_slide__label"><span class="h3">Mi</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Microscopy</span> <p>Faster, gentler, higher-resolution biological imaging</p> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__6"> <div class="card_slide__label"><span class="h3">Ph</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Physiology</span> <div class="BlockSlider__ListItem-sc-1ph9zyl-4 hRWlMa aos-init aos-animate" data-aos="fade-up" data-aos-delay="600"> <div class="BlockSlider__ListItemContainer-sc-1ph9zyl-6 gsHLpX"> <p class="Text__Small-sc-1fxfdhx-7 BlockSlider__ListItemLabel-sc-1ph9zyl-5 jfMrXs">Developing preclinical models with deeper understanding of disease pathophysiology</p> </div> </div> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__7"> <div class="card_slide__label"><span class="h3">Pa</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Pharmacology</span> <p>Pharmacodynamic and efficacy models, PK/PD correlation and pharmacological research</p> </div> </div> </div> <div class="card_slide"> <div class="card_slide__inner from-bottom__8"> <div class="card_slide__label"><span class="h3">Pr</span></div> <div class="card_slide__content"> <span class="card_slide__heading">Preclinical Imaging</span> <p>Non-invasive imaging to understand changes in physiology and identify biomarkers</p> </div> </div> </div> </div> </div> <div id="sizing_container_block_efa53e2cb379ec3ef05290964078dbcc" class="sizing-container section__margin_auto container__default mt-default mb-6 pt-default pb-default mobile-mt-3 mobile-mb-1 mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <figure class="media_block from-bottom__0 no_aspect_ratio mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default media_type_image alignment_dt_left alignment_mb_left size_dt_auto size_mb_auto" id="media_block_block_1cd562f3cdaa07d6daed6f0d0dde4984" style=""> <picture class=""> <source media="(max-width:768px)" data-srcset="https://www.calicolabs.com/wp-content/uploads/2020/05/tech_img_mobile@2x.jpg"> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-1024x624.jpg" data-srcset="https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-1024x624.jpg 1024w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-300x183.jpg 300w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-768x468.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-1536x935.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-2048x1247.jpg 2048w" data-sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="" width="2220" height="1352" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2220px; --smush-placeholder-aspect-ratio: 2220/1352;"><noscript><img decoding="async" src="https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-1024x624.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-1024x624.jpg 1024w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-300x183.jpg 300w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-768x468.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-1536x935.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2020/05/computing_img_2@2x-2048x1247.jpg 2048w" sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="" width="2220" height="1352" loading="lazy"></noscript> </picture> </figure> </div> </div> <div id="sizing_container_block_f17011e2cc51d06ef80ddf7c149f7e1e" class="sizing-container section__margin_auto container__small mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h4 id="heading_block_aaaa241737951defe050cffba6f91aac" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default eyebrow align-left align-left-mobile"> Computing </h4> <h2 id="heading_block_1c993fec88804ddecb718f8d9a5e308e" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Answering the big questions requires iterating between theory and experiment </h2> <ul class="table_list mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default label-font-size-auto content-font-size-" id="table_listblock_4e9d3250597c5f41ed947e1bb359f4bc" style=""> <li class="table_list__item from-bottom__0"> <div class="table_list__heading"> <span>Biology has become an informatics field</span> </div> <div class="table_list__content"> <p>The amount of scientific data being generated by new high-throughput technologies far outpaces the ability to interpret it. Our Computing team works closely with our R&D colleagues to understand which data that we create may generate the most impactful hypotheses. We then design experiments to test these hypotheses, and interpret, learn and generate more hypotheses that help us understand aging better.</p> <p>We use advanced computing to answer meaningful biological questions and advance clinical research. We aim to accelerate scientific discovery by collaborating closely with our colleagues and collaborators to build infrastructure, develop software, advance technology and invent new methods and algorithms.</p> </div> </li> <li class="table_list__item from-bottom__0"> <div class="table_list__heading"> <span>Freedom to explore, technology to lead the way</span> </div> <div class="table_list__content"> <p>Our team of machine learning experts, software engineers and data scientists bring quantitative rigor to the study of aging and age-related disease. We’re interpreting large sets of genotypic and phenotypic data from model organisms and humans to enable new insights into how we age; we’re using machine learning and advanced computer vision to analyze images generated by our various research labs; and we’re using computing to measure genomic, metabolic and physiological traits to observe and better understand the changes that occur as an organism ages — just to name a few of our ongoing efforts.</p> <p><strong><a href="https://www.calicolabs.com/story/power-couple-ai-together-with-cryo-em-reveals-new-insights-into-age-related-protein">See how members of the Technology and Computing teams combine the power of AI and advanced microscopy to reveal new insights into age-related proteins</a></strong></p> </div> </li> </ul> </div> </div> </div> </section> <section id="page_section_block_03b48d35d1e71d4da26e729bb2e0f046" class="page-section mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default block_background background_type_color " style="--background-color:#ffffff;"> <div class="acf-innerblocks-container"> <div id="sizing_container_block_efa53e2cb379ec3ef05290964078dbcc" class="sizing-container section__margin_auto container__default mt-default mb-6 pt-default pb-default mobile-mt-3 mobile-mb-1 mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <figure class="media_block from-bottom__0 has_aspect_ratio aspect_ratio_mb mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default media_type_image alignment_dt_left alignment_mb_left size_dt_auto size_mb_auto" id="media_block_block_d95b12b375ce9b4287e462d8e4fbfa0b" style="--aspect-ratio-mb:750/672;--media-position-mb:center;"> <img decoding="async" data-src="https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-1024x683.jpg" data-srcset="https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-1024x683.jpg 1024w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-300x200.jpg 300w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-768x512.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-1536x1025.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-2048x1366.jpg 2048w" data-sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="Ellie and Aimee" width="2400" height="1601" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="lazyload" style="--smush-placeholder-width: 2400px; --smush-placeholder-aspect-ratio: 2400/1601;"><noscript><img decoding="async" class="" src="https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-1024x683.jpg" srcset="https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-1024x683.jpg 1024w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-300x200.jpg 300w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-768x512.jpg 768w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-1536x1025.jpg 1536w, https://www.calicolabs.com/wp-content/uploads/2023/09/Ellie-and-Aimee-2048x1366.jpg 2048w" sizes="auto, (max-width: 2000px) 100vw, 2000px" alt="Ellie and Aimee" width="2400" height="1601" loading="lazy"></noscript> </figure> </div> </div> <div id="sizing_container_block_f17011e2cc51d06ef80ddf7c149f7e1e" class="sizing-container section__margin_auto container__small mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default" style=""> <div class="sizing-container_wrapper"> <h4 id="heading_block_a26a11280fb98eb076d4e3ac80a9cabc" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default eyebrow align-left align-left-mobile"> Partnering with Calico </h4> <h2 id="heading_block_442283c4db5310ee3ab2bc5711ebc115" class="custom_heading from-bottom__0 mt-default mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default align-left align-left-mobile"> Why collaborate with Calico </h2> <p>We are different by design. Calico combines the focus and drive of a start-up with the resources and world class R&D capabilities of the leading biotechnology and pharmaceutical companies. Partnering with Calico, therefore, provides a different type of collaboration ⁠— a mindset focused on tackling big, complex scientific questions, scientists who enjoy the opportunity to explore new avenues of research, a culture that supports collaborative efforts, and a commitment to developing potential new interventions that may improve the quality of life during aging and benefit patients.</p> <p id="cta_block_8df76ba03f0dda20316a13bc1fc8fc88_p" class="btn__block mt-3 mb-default pt-default pb-default mobile-mt-default mobile-mb-default mobile-pt-default mobile-pb-default"> <a id="cta_block_8df76ba03f0dda20316a13bc1fc8fc88" class="btn btn__simple green width_auto alignment_dt_left alignment_mb_left " style="" href="https://calicolabs.wpenginepowered.com/partnering/" target="">Read More</a> </p> </div> </div> </div> </section> </div> </article> </main> </div> </div> <footer id="colophon" class="site-footer"> <div class="site-footer__container container"> <div class="site-footer__logo 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