D2R | de l'ADN à l'ARN sur LinkedIn : This morning, we had the privilege of hosting an insightful Breakfast &…

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{"@context":"http://schema.org","@type":"SocialMediaPosting","@id":"https://fr.linkedin.com/posts/d2r-dna-to-rna_this-morning-we-had-the-privilege-of-hosting-activity-7262914383423451137-51i7","datePublished":"2024-11-14T19:48:47.400Z","image":{"url":"https://media.licdn.com/dms/image/v2/D4E22AQGjNiBgg2IcvQ/feedshare-shrink_2048_1536/feedshare-shrink_2048_1536/0/1731613722628?e=2147483647&v=beta&t=Wirs6eg5Zf_cVmmjMYrKrUTLG5OMAcXhekPSfjiQmjY","@type":"ImageObject"},"articleBody":"This morning, we had the privilege of hosting an insightful Breakfast & Learn session with PacBio, where experts from PacBio and researchers at McGill came together to discuss sequencing technologies to accelerate genomic research.\n\nA special thank you to our incredible speakers:\n✔ Janet Prince, Senior Industry Liaison, D2R\n✔Mathieu Bourgey, Data Science Director, D2R\n✔Patty Mudivarti, Senior Specialist, Sequencing Applications, PacBio\n✔Ioannis (Jiannis) Ragoussis, Professor of Human Genetics and Head of Genome Sciences at McGill Genome Centre\n✔Haïg Djambazian, Academic Associate, McGill Institute of Genomic Medicine\n\nThank you again to everyone who attended!\n\n***\n\nCe matin, nous avons eu le privilège d'organiser un Breakfast & Learn avec PacBio, où des experts de PacBio et des chercheurs de McGill se sont réunis pour discuter des technologies de séquençage afin d'accélérer la recherche génomique.\n\nNous remercions nos incroyables conférenciers :\n✔Janet Prince, Agente de liaison principale avec les industries, D2R\n✔Mathieu Bourgey, Directeur en science des données, D2R\n✔Patty Mudivarti, Spécialiste principale des applications de séquençage, PacBio\n✔Ioannis (Jiannis) Ragoussis, Professeur de génétique humaine et chef du département des sciences du génomec au Centre de génomique McGill\n✔Haïg Djambazian, Associé aux activités professorales, Institut de médecine génomique de McGill\n\nMerci encore à tous les participants 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leading-[1.33333] m-0 truncate">  1 013 abonnés </p> <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 1 sem.  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Ouvrir le menu" data-tracking-control-name="public_post_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list hidden container-raised absolute w-auto overflow-y-auto flex-col items-stretch z-1 bottom-auto top-[100%]" role="menu" tabindex="-1"> <li class="ellipsis-menu__item border-t-1 border-solid border-color-border-low-emphasis first-of-type:border-none flex"> <a href="https://www.linkedin.com/uas/login?session_redirect=https%3A%2F%2Ffr.linkedin.com%2Fposts%2Fd2r-dna-to-rna_this-morning-we-had-the-privilege-of-hosting-activity-7262914383423451137-51i7&trk=public_post_ellipsis-menu-semaphore-sign-in-redirect&guestReportContentType=POST&_f=guest-reporting" data-tracking-control-name="public_post_ellipsis-menu-semaphore-sign-in-redirect" data-tracking-will-navigate data-item-type="semaphore" data-semaphore-content-type="POST" data-semaphore-content-urn="urn:li:activity:7262914383423451137" data-semaphore-tracking-prefix="public_post_ellipsis-menu-semaphore" data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint focus:bg-color-background-container-tint hover:bg-color-background-container-tint outline-offset-[-2px]">  <icon class="ellipsis-menu__item-icon text-color-text h-[24px] w-[24px] mr-1" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/iq0x9q37wj214o129ai1yjut"> </icon> Signaler ce post </a>  </li>  </ul>  </div> </div> </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">This morning, we had the privilege of hosting an insightful Breakfast & Learn session with <a class="link" href="https://www.linkedin.com/company/pacbio?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>PacBio</a>, where experts from PacBio and researchers at McGill came together to discuss sequencing technologies to accelerate genomic research. A special thank you to our incredible speakers: ✔ <a class="link" href="https://ca.linkedin.com/in/janet-prince-3899b86?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Janet Prince</a>, Senior Industry Liaison, D2R ✔<a class="link" href="https://ca.linkedin.com/in/mathieubourgey?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Mathieu Bourgey</a>, Data Science Director, D2R ✔<a class="link" href="https://www.linkedin.com/in/patty-mudivarti-1b4aa87?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Patty Mudivarti</a>, Senior Specialist, Sequencing Applications, <a class="link" href="https://www.linkedin.com/company/pacbio?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>PacBio</a> ✔<a class="link" href="https://ca.linkedin.com/in/ioannis-jiannis-ragoussis-6ba311a4?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Ioannis (Jiannis) Ragoussis</a>, Professor of Human Genetics and Head of Genome Sciences at <a class="link" href="https://ca.linkedin.com/company/mcgill-genome-centre?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>McGill Genome Centre</a> ✔<a class="link" href="https://ca.linkedin.com/in/ha%C3%AFg-djambazian-a76640?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Haïg Djambazian</a>, Academic Associate, McGill Institute of Genomic Medicine Thank you again to everyone who attended! *** Ce matin, nous avons eu le privilège d'organiser un Breakfast & Learn avec <a class="link" href="https://www.linkedin.com/company/pacbio?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>PacBio</a>, où des experts de PacBio et des chercheurs de McGill se sont réunis pour discuter des technologies de séquençage afin d'accélérer la recherche génomique. Nous remercions nos incroyables conférenciers : ✔<a class="link" href="https://ca.linkedin.com/in/janet-prince-3899b86?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Janet Prince</a>, Agente de liaison principale avec les industries, D2R ✔<a class="link" href="https://ca.linkedin.com/in/mathieubourgey?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Mathieu Bourgey</a>, Directeur en science des données, D2R ✔<a class="link" href="https://www.linkedin.com/in/patty-mudivarti-1b4aa87?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Patty Mudivarti</a>, Spécialiste principale des applications de séquençage, PacBio ✔<a class="link" href="https://ca.linkedin.com/in/ioannis-jiannis-ragoussis-6ba311a4?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Ioannis (Jiannis) Ragoussis</a>, Professeur de génétique humaine et chef du département des sciences du génomec au Centre de génomique McGill ✔<a class="link" href="https://ca.linkedin.com/in/ha%C3%AFg-djambazian-a76640?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Haïg Djambazian</a>, Associé aux activités professorales, Institut de médecine génomique de McGill Merci encore à tous les participants !</p>  </div> <ul class="grid grid-cols-6 grid-rows-[60%_40%] w-main-feed-card-media feed-images-content list-none pl-0 gap-0.125 h-[425px] babybear:h-[360px]" data-test-id="feed-images-content"> <li class="bg-color-background-container-tint text-[0px] col-span-full " data-test-id="feed-images-content__list-item" data-position="0"> <img class="lazy-load w-full object-cover object-center h-full babybear:max-h-[400px]" 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pour Rafa&#39;s Moonshot, visuel">  </a> <div class="flex flex-col self-start min-w-0 ml-1 "> <div class="text-color-text "> <a class="text-sm link-styled no-underline leading-open" href="https://il.linkedin.com/company/rafas-moonshot?trk=public_post_feed-actor-name" data-tracking-control-name="public_post_feed-actor-name" aria-label="Voir la page Organisation pour Rafa&#39;s Moonshot" data-tracking-will-navigate> Rafa's Moonshot </a>  </div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  407 abonnés </p> <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 1 mois  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger 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By mapping approximately 3 billion DNA base pairs, the HGP provided the genetic "blueprint" that guides our work in developing treatments for STXBP1 and other rare genetic disorders. But what made the HGP so revolutionary? ✅ The primary objectives included sequencing the human DNA and identifying all human genes, effectively creating a "blueprint" for human biology. ✅ The project also sequenced the genomes of model organisms like yeast, bacteria, and mice, broadening our understanding of genetics. ✅ To achieve this feat, scientists developed new sequencing technologies and data analysis tools that continue to shape genomics research today. ✅ The HGP established an open approach to data sharing, which paved the way for future large-scale collaborative research. The Human Genome Project has profoundly impacted biology and medicine by identifying genes linked to various diseases, which has paved the way for personalized medicine and more effective treatments. By mapping human DNA, the HGP transformed biological research, allowing scientists to study human evolution, disease mechanisms, and more. At Rafa's Moonshot, we build upon these advances, using genomic insights to guide our research and develop targeted therapies for rare genetic disorders. <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fhumangenomeproject&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#HumanGenomeProject</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenomics&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#Genomics</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fscientificcollaboration&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#ScientificCollaboration</a> 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PhD" data-tracking-will-navigate> Alexis MOUGEOLLE, PhD </a>  </div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  Aide les Biotech & Pharma à améliorer leurs performances en R&D • Sr Key Account Manager • Life Sciences • </p> <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 4 mois  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Ouvrir le menu" data-tracking-control-name="public_post_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" 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dans la programmation génomique ! Les systèmes guidés par ARN ont transformé la biologie, simplifiant la reprogrammation moléculaire. Cependant, ces systèmes coupent ou détruisent leurs cibles. Après deux ans et demi de recherche, les scientifiques de l'Arc Institute ont découvert un nouveau système compact capable d'insérer directement des séquences d'ADN dans le génome à l'aide d'ARN de pont, une nouvelle classe d'ARN guides. Cette étude, publiée dans Nature, présente le premier recombinase ADN utilisant un ARN non codant pour sélectionner séquentiellement les cibles et les molécules d'ADN donneur. Programmable, cet ARN de pont permet de spécifier toute séquence génomique cible et toute molécule d'ADN à insérer. "Le système d'ARN de pont est un mécanisme fondamentalement nouveau pour la conception de génomes," explique Dr. Patrick Hsu, auteur principal et professeur adjoint de bioingénierie à l'Université de Californie, Berkeley. "La recombinaison par pont permet des modifications génétiques universelles, offrant un outil de conception de génomes au-delà de CRISPR." Perspectives Futures Ce mécanisme promet de surpasser les technologies CRISPR, permettant des réarrangements ADN programmables. Les recherches futures viseront à adapter ce système aux cellules humaines et à améliorer sa précision. Pour lire l'article : <a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FdUvr7VY7&urlhash=uGIH&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/dUvr7VY7</a></p> <button class="attributed-text-segment-list__btn-truncation absolute right-0 bottom-0 pl-1 bg-color-background-container text-color-text-secondary text-sm font-medium babybear:font-bold invisible cursor-pointer hover:text-color-link-hover hover:underline" data-feed-action="see-more-post" data-feed-action-category="EXPAND" data-feed-action-type="expandCommentaryText" data-feed-control="commentary_expand" aria-hidden="true" tabindex="0"> …plus </button> </div> <div class="flex flex-col " data-test-id="ingested-content-summary-external-video-content"> <iframe allowfullscreen data-delayed-url="https://www.youtube-nocookie.com/embed/hJ7zvZTxgT4?modestbranding=1&rel=0&autoplay=0&hl=fr" frameborder="0" 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initiatives to enhance diversity in genomics research? Check out this fact sheet to learn about their several projects! <a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FgF3BqkUv&urlhash=p0sq&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/gF3BqkUv</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenomicdiversity&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#GenomicDiversity</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenomics&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#Genomics</a></p>  </div>  <a 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data-tracking-control-name="public_post-text" data-tracking-will-navigate>Genoscope - Centre National de Séquençage</a>! Title: Développement de méthodes et d'outils en pangénomique pour l'analyse en génomique microbienne Résumé: Les procaryotes, qui comprennent les bactéries et les archées, constituent un domaine fascinant d'organismes vivants, représentant une diversité et une ubiquité remarquables. Leur impact sur la biosphère est immense, influençant la santé humaine et animale, la biogéochimie des sols et des océans, et bien d'autres choses encore. L'exploration à grande échelle des génomes microbiens a permis de découvrir les mécanismes moléculaires qui sous-tendent leur diversité, et en particulier le rôle des éléments génétiques mobiles. Ces dernières années, l'explosion des projets de séquençage a permis de stocker des centaines de milliers de génomes dans des bases de données publiques, offrant ainsi de nouvelles possibilités d'explorer la diversité, l'évolution, la physiologie et les interactions des procaryotes. Cependant, ces données repoussent les limites des approches génomiques classiques. De nouvelles méthodes et de nouveaux outils utilisant le concept de pangénomes sont apparus pour relever les défis de l'analyse génomique. La pangénomique vise à comprendre la variabilité génétique d'un groupe d'organismes, généralement d’une même espèce, en agrégeant l’information issue de l’ensemble des génomes disponibles plutôt que d’utiliser un seul génome de référence ou de réaliser des comparaisons deux à deux. Dans cette optique, le laboratoire LABGeM (<a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FeEF7KeqB&urlhash=N8Pp&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/eEF7KeqB</a>) travaille depuis plusieurs années sur un modèle de représentation des données génomiques sous forme de graphe de pangénomes au niveau des familles de gènes, permettant de compresser l'information de milliers de génomes tout en préservant l'organisation chromosomique des gènes. Nous développons ainsi tout un écosystème d’outils et de bases de données autour de la suite logicielle PPanGGOLiN (<a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FeCQPUEJv&urlhash=iWiK&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/eCQPUEJv</a>) dans le but de permettre aux microbiologistes de réaliser des analyses génomique à grande échelle en analysant plusieurs dizaines voire centaines de génomes de la même espèce. Ce type d’analyse permet de mieux appréhender la dynamique évolutive en termes de transferts horizontaux de modules fonctionnels à l’origine de l'adaptation des microorganismes à différents écosystèmes par une diversification de leur métabolisme.</p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flabgem%2Egenoscope%2Ecns%2Efr%2F&urlhash=bevJ&trk=public_post_feed-article-content" target="_self" data-tracking-control-name="public_post_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content"> <img alt="LABGeM prokaryote metabolism and genomics, MicroScope platform" class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/sync/v2/C4D27AQHMhqPx3EHs8Q/articleshare-shrink_800/articleshare-shrink_800/0/1720777918989?e=2147483647&v=beta&t=WEmd8_AbHhqEDucOnXk0nDUBO4NCOx6hoLEOkNIaM44" 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Cette étude offre des informations précieuses sur la remarquable résistance des tardigrades aux radiations ionisantes en montrant que le traitement par radiations induit une série de protéines de réparation de l'ADN. Dans cet article, les auteurs ont identifié une protéine de liaison à l'ADN spécifique aux tardigrades, fortement induite, qui peut réduire le nombre de cassures double brin dans des cellules humaines dérivées de cancers. Les résultats sont particulièrement impactants dans les domaines de la réparation de l'ADN et de la radiobiologie ainsi que les biologistes travaillant avec les tardigrades. <a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FgyGHddbD&urlhash=qKbH&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/gyGHddbD</a> Ici sur HAL en version BIORXIV : <a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FgfP8J8pS&urlhash=kpMP&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/gfP8J8pS</a></p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Felifesciences%2Eorg%2Freviewed-preprints%2F92621v1&urlhash=O1Bb&trk=public_post_feed-article-content" target="_self" 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This study by <a class="link" href="https://www.linkedin.com/school/harvard-university/?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Harvard University</a> delves into UCEs to resolve complex family relationships across Bivalvia, using innovative probe sets and computational tools like CIPRES for robust phylogenetic inference. <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fphylogenomics&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#Phylogenomics</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fnextgensequencing&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#NextGenSequencing</a> <a class="link" 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data-tracking-will-navigate>#scienceouverte</a> en partageant avec vous notre manuscrit détaillé résumant les méthodes que nous avons utilisées pour relever ce défi : <a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FdRGxc-n8&urlhash=69iY&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/dRGxc-n8</a> Dans ce défi CACHE, nous avons utilisé la méthode de conception moléculaire guidée par l'homme et par l'<a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fapprentissagemachine&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#apprentissagemachine</a> pour proposer de nouveaux modèles chimiques susceptibles de rivaliser avec le substrat de la NSP3. Pour tester et filtrer nos <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2FpetitesmolAezcules&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#petitesmolécules</a> conçues par l'<a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fia&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#IA</a>, nous avons mis à jour notre programme de docking <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Ffitted&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#FITTED</a> afin d'effectuer un docking basé sur un modèle à partir de fragments cristallisés. Nous sommes fiers de continuer à contribuer à la science en libre accès et à la <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2FdAezcouvertedemAezdicaments&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#découvertedemédicaments</a>. Consultez également nos manuscrits résultant des deux premiers défis : <a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FdnEN24CK&urlhash=0P4w&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/dnEN24CK</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fcompchem&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#compchem</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Ftransparence&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#transparence</a> </p>  </div>  <a href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Fchemrxiv%2Eorg%2Fengage%2Fchemrxiv%2Farticle-details%2F65c6e60b66c1381729521e8f&urlhash=ANz2&trk=public_post_feed-article-content" target="_self" data-tracking-control-name="public_post_feed-article-content" data-tracking-will-navigate class="flex flex-col feed-article-content" data-test-id="article-content"> <img alt="The Third CACHE Challenge – Finding Ligands Targeting the Macrodomain of SARS-CoV-2 NSP3 Using AI-inspired and Knowledge-Based Approaches." class="lazy-load w-main-feed-card-media object-cover babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/sync/v2/D4D27AQFbP8Nfip0xSg/articleshare-shrink_800/articleshare-shrink_800/0/1711575948378?e=2147483647&v=beta&t=1bsrI18ASVMCXwqS5kwE9iSk89QYLd8kNc2dYeQuksY" data-ghost-classes="tw-feed-content-ghost-image" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/42byfw7gh464l64dlwodbbdez">  <section class="flex justify-between 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text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">Exciting New Insights into DNA Structure! In a groundbreaking study, researchers have mapped DNA i-motif structures in human cells using innovative techniques like high-affinity i-motif immunoprecipitation and sequencing. While i-motifs have been previously observed in human cells, their precise abundance and distribution within the genome were unclear—until now. Through this approach, validated by advanced spectroscopy, scientists uncovered that i-motifs are widely distributed throughout the human genome, particularly in genes upregulated during the G0/G1 cell cycle phases. This discovery opens new doors for understanding how these unique DNA structures contribute to genomic regulation and cellular function. This study not only provides critical insights into the role of i-motifs but also lays the foundation for future research exploring their potential implications in human biology and disease. <a class="link" href="https://www.linkedin.com/redir/redirect?url=https%3A%2F%2Flnkd%2Ein%2FeRZ9Xy9i&urlhash=NeDD&trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/eRZ9Xy9i</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenomics&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#Genomics</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fdnaresearch&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#DNAResearch</a> <a 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block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-en_US" data-locale="en_US" role="menuitem" lang="en_US"> English (Anglais) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Español (Espagnol)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-es_ES" data-locale="es_ES" role="menuitem" lang="es_ES"> Español (Espagnol) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="فارسی (Perse)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-fa_IR" data-locale="fa_IR" role="menuitem" lang="fa_IR"> فارسی (Perse) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Suomi (Finnois)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-fi_FI" data-locale="fi_FI" role="menuitem" lang="fi_FI"> Suomi (Finnois) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Français (Français) sélectionné" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link--selected" data-tracking-control-name="language-selector-fr_FR" data-locale="fr_FR" role="menuitem" lang="fr_FR"> <strong>Français (Français)</strong> </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="हिंदी (Hindi)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-hi_IN" data-locale="hi_IN" role="menuitem" lang="hi_IN"> हिंदी (Hindi) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Magyar (Hongrois)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-hu_HU" data-locale="hu_HU" role="menuitem" lang="hu_HU"> Magyar (Hongrois) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Bahasa Indonesia (Indonésien)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-in_ID" data-locale="in_ID" role="menuitem" lang="in_ID"> Bahasa Indonesia (Indonésien) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Italiano (Italien)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-it_IT" data-locale="it_IT" role="menuitem" lang="it_IT"> Italiano (Italien) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="עברית (Hébreu)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-iw_IL" data-locale="iw_IL" role="menuitem" lang="iw_IL"> עברית (Hébreu) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="日本語 (Japonais)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-ja_JP" data-locale="ja_JP" role="menuitem" lang="ja_JP"> 日本語 (Japonais) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="한국어 (Coréen)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-ko_KR" data-locale="ko_KR" role="menuitem" lang="ko_KR"> 한국어 (Coréen) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="मराठी (Marathi)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-mr_IN" data-locale="mr_IN" role="menuitem" lang="mr_IN"> मराठी (Marathi) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Bahasa Malaysia (Malaisien)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-ms_MY" data-locale="ms_MY" role="menuitem" lang="ms_MY"> Bahasa Malaysia (Malaisien) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Nederlands (Néerlandais)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-nl_NL" data-locale="nl_NL" role="menuitem" lang="nl_NL"> Nederlands (Néerlandais) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Norsk (Norvégien)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-no_NO" data-locale="no_NO" role="menuitem" lang="no_NO"> Norsk (Norvégien) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="ਪੰਜਾਬੀ (Penjabi)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-pa_IN" data-locale="pa_IN" role="menuitem" lang="pa_IN"> ਪੰਜਾਬੀ (Penjabi) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Polski (Polonais)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-pl_PL" data-locale="pl_PL" role="menuitem" lang="pl_PL"> Polski (Polonais) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Português (Portugais)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-pt_BR" data-locale="pt_BR" role="menuitem" lang="pt_BR"> Português (Portugais) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Română (Roumain)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-ro_RO" data-locale="ro_RO" role="menuitem" lang="ro_RO"> Română (Roumain) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Русский (Russe)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-ru_RU" data-locale="ru_RU" role="menuitem" lang="ru_RU"> Русский (Russe) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Svenska (Suédois)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-sv_SE" data-locale="sv_SE" role="menuitem" lang="sv_SE"> Svenska (Suédois) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="తెలుగు (Télougou)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-te_IN" data-locale="te_IN" role="menuitem" lang="te_IN"> తెలుగు (Télougou) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="ภาษาไทย (Thaï)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-th_TH" data-locale="th_TH" role="menuitem" lang="th_TH"> ภาษาไทย (Thaï) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Tagalog (Tagalog)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-tl_PH" data-locale="tl_PH" role="menuitem" lang="tl_PH"> Tagalog (Tagalog) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Türkçe (Turc)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-tr_TR" data-locale="tr_TR" role="menuitem" lang="tr_TR"> Türkçe (Turc) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Українська (Ukrainien)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-uk_UA" data-locale="uk_UA" role="menuitem" lang="uk_UA"> Українська (Ukrainien) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Tiạng Viạt (Vietnamien)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-vi_VN" data-locale="vi_VN" role="menuitem" lang="vi_VN"> Tiạng Viạt (Vietnamien) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="简体中文 (Chinois simplifié)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-zh_CN" data-locale="zh_CN" role="menuitem" lang="zh_CN"> 简体中文 (Chinois simplifié) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="正體中文 (Chinois traditionnel)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-zh_TW" data-locale="zh_TW" role="menuitem" lang="zh_TW"> 正體中文 (Chinois traditionnel) </button> </li>  </ul> <button class="language-selector__button select-none relative pr-2 font-sans text-xs font-bold text-color-text-low-emphasis hover:text-color-link-hover hover:cursor-pointer focus:text-color-link-focus focus:outline-dotted focus:outline-1" aria-expanded="false" data-tracking-control-name="footer-lang-dropdown_trigger"> <span class="language-selector__label-text mr-0.5 break-words"> Langue </span> <icon class="language-selector__label-chevron w-2 h-2 absolute top-0 right-0" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/cyolgscd0imw2ldqppkrb84vo"></icon> </button> </div> </li> </ul>  </footer> <div class="contextual-sign-in-modal" data-impression-id="public_post_contextual-sign-in-modal" data-cool-off-enabled data-show-on-page-load>  <div class>  <div id="public_post_contextual-sign-in" class="modal modal--contextual-sign-in" data-outlet="public_post_contextual-sign-in">  <div class="modal__overlay flex items-center bg-color-background-scrim justify-center fixed bottom-0 left-0 right-0 top-0 opacity-0 invisible pointer-events-none z-[1000] transition-[opacity] ease-[cubic-bezier(0.25,0.1,0.25,1.0)] duration-[0.17s] py-4 " aria-hidden="true"> <section aria-modal="true" role="dialog" aria-labelledby="public_post_contextual-sign-in-modal-header" tabindex="-1" class="max-h-full modal__wrapper overflow-auto p-0 bg-color-surface max-w-[1128px] min-h-[160px] relative scale-[0.25] shadow-sm shadow-color-border-faint transition-[transform] ease-[cubic-bezier(0.25,0.1,0.25,1.0)] duration-[0.33s] focus:outline-0 w-[1128px] mamabear:w-[744px] babybear:w-[360px] rounded-md"> <button class="modal__dismiss btn-tertiary h-[40px] w-[40px] p-0 rounded-full indent-0 contextual-sign-in-modal__modal-dismiss absolute right-0 m-[20px] cursor-pointer" aria-label="Ignorer" data-tracking-control-name="public_post_contextual-sign-in-modal_modal_dismiss"> <icon class="contextual-sign-in-modal__modal-dismiss-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/gs508lg3t2o81tq7pmcgn6m2"></icon> </button> <div class="modal__main w-full"> <div class="contextual-sign-in-modal__screen contextual-sign-in-modal__context-screen flex flex-col my-4 mx-3"> <img class="inline-block relative w-16 h-16 contextual-sign-in-modal__img m-auto" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/5k9cgtx8rhoyqkcxfoncu1svl" data-ghost-classes="bg-color-entity-ghost-background" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/9l8dv1r8a09nem281grvopn9l" alt> <h2 class="contextual-sign-in-modal__context-screen-title font-sans text-xl text-color-text my-2 mx-4 text-center" id="public_post_contextual-sign-in-modal-header"> Découvrez plus d’informations sur le secteur </h2> <p class="contextual-sign-in-modal__subtitle mb-2 mx-12 babybear:mx-0 text-center font-sans text-md text-color-text"> Créez votre compte gratuit ou identifiez-vous pour continuer votre recherche </p>  <div class="contextual-sign-in-modal__btn-container m-auto w-[320px] babybear:w-full">  <div class="w-full max-w-[400px] mx-auto"> <div class="google-auth-button">  <div class="google-auth-button__placeholder " data-theme="filled_blue" data-logo-alignment="center"></div>  </div> </div> <div class="sign-in-modal" data-impression-id="public_post_contextual-sign-in-modal_sign-in-modal"> <button class="sign-in-modal__outlet-btn cursor-pointer btn-md btn-primary btn-secondary" data-tracking-client-ingraph data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_outlet-button" data-modal="public_post_contextual-sign-in_sign-in-modal">  S’identifier </button> <div class>  <div id="public_post_contextual-sign-in_sign-in-modal" class="modal modal--sign-in" data-outlet="public_post_contextual-sign-in_sign-in-modal">  <div class="modal__overlay flex items-center bg-color-background-scrim justify-center fixed bottom-0 left-0 right-0 top-0 opacity-0 invisible pointer-events-none z-[1000] transition-[opacity] ease-[cubic-bezier(0.25,0.1,0.25,1.0)] duration-[0.17s] py-4 " aria-hidden="true"> <section aria-modal="true" role="dialog" aria-labelledby="public_post_contextual-sign-in_sign-in-modal-modal-header" tabindex="-1" class="max-h-full modal__wrapper overflow-auto p-0 bg-color-surface max-w-[1128px] min-h-[160px] relative scale-[0.25] shadow-sm shadow-color-border-faint transition-[transform] ease-[cubic-bezier(0.25,0.1,0.25,1.0)] duration-[0.33s] focus:outline-0 w-[1128px] mamabear:w-[744px] babybear:w-[360px] rounded-md"> <button class="modal__dismiss btn-tertiary h-[40px] w-[40px] p-0 rounded-full indent-0 sign-in-modal__dismiss absolute right-0 cursor-pointer m-[20px]" aria-label="Ignorer" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_dismiss"> <icon class="sign-in-modal__dismiss-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/gs508lg3t2o81tq7pmcgn6m2"></icon> </button> <div class="modal__main w-full"> <div class="sign-in-modal__screen flex flex-col py-4 w-[513px] babybear:w-full px-3"> <h2 class="sign-in-modal__header font-sans text-display-md text-color-text "> Bon retour parmi nous </h2> <code id="i18n_sign_in_form_show_text" style="display: none"></code> <code id="i18n_sign_in_form_show_label" style="display: none"></code> <code id="i18n_sign_in_form_hide_text" style="display: none"></code> <code id="i18n_sign_in_form_hide_label" style="display: none"></code> <code id="i18n_username_error_empty" style="display: none"></code> <code id="i18n_username_error_too_long" style="display: none"></code> <code id="i18n_username_error_too_short" style="display: none"></code> <code id="i18n_password_error_empty" style="display: none"></code> <code id="i18n_password_error_too_short" style="display: none"></code> <code id="i18n_password_error_too_long" style="display: none"></code>  <form data-id="sign-in-form" action="https://www.linkedin.com/uas/login-submit" method="post" novalidate class="mt-1.5 mb-2"> <input name="loginCsrfParam" value="5ecf3876-2f32-4cb3-8d18-cf8aeb43bf7c" type="hidden"> <div class="flex flex-col"> <div class="mt-1.5" data-js-module-id="guest-input"> <div class="flex flex-col"> <label class="input-label mb-1" for="public_post_contextual-sign-in_sign-in-modal_session_key"> E-mail ou téléphone </label> <div class="text-input flex"> <input class="text-color-text font-sans text-md outline-0 bg-color-transparent grow" autocomplete="username" id="public_post_contextual-sign-in_sign-in-modal_session_key" name="session_key" required data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_sign-in-session-key" data-tracking-client-ingraph type="text"> </div> </div> <p class="input-helper mt-1.5" for="public_post_contextual-sign-in_sign-in-modal_session_key" role="alert" data-js-module-id="guest-input__message"></p> </div> <div class="mt-1.5" data-js-module-id="guest-input"> <div class="flex flex-col"> <label class="input-label mb-1" for="public_post_contextual-sign-in_sign-in-modal_session_password"> Mot de passe </label> <div class="text-input flex"> <input class="text-color-text font-sans text-md outline-0 bg-color-transparent grow" autocomplete="current-password" id="public_post_contextual-sign-in_sign-in-modal_session_password" name="session_password" required data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_sign-in-password" data-tracking-client-ingraph type="password"> <button aria-live="assertive" aria-relevant="text" data-id="sign-in-form__password-visibility-toggle" class="font-sans text-md font-bold text-color-action z-10 ml-[12px] hover:cursor-pointer" aria-label="Affichez votre mot de passe LinkedIn" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_sign-in-password-visibility-toggle-btn" type="button">Afficher</button> </div> </div> <p class="input-helper mt-1.5" for="public_post_contextual-sign-in_sign-in-modal_session_password" role="alert" data-js-module-id="guest-input__message"></p> </div> <input name="session_redirect" value="https://fr.linkedin.com/posts/d2r-dna-to-rna_this-morning-we-had-the-privilege-of-hosting-activity-7262914383423451137-51i7" type="hidden">  </div> <div data-id="sign-in-form__footer" class="flex justify-between sign-in-form__footer--full-width"> <a data-id="sign-in-form__forgot-password" class="font-sans text-md font-bold link leading-regular sign-in-form__forgot-password--full-width" href="https://www.linkedin.com/uas/request-password-reset?trk=public_post_contextual-sign-in-modal_sign-in-modal_forgot_password" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_forgot_password" data-tracking-will-navigate>Mot de passe oublié ?</a>  <input name="trk" value="public_post_contextual-sign-in-modal_sign-in-modal_sign-in-submit" type="hidden"> <button class="btn-md btn-primary flex-shrink-0 cursor-pointer sign-in-form__submit-btn--full-width" data-id="sign-in-form__submit-btn" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_sign-in-submit-btn" data-tracking-client-ingraph data-tracking-litms type="submit"> S’identifier </button> </div> <div class="sign-in-form__divider left-right-divider pt-2 pb-3"> <p class="sign-in-form__divider-text font-sans text-sm text-color-text px-2"> ou </p> </div> </form> <div class="w-full max-w-[400px] mx-auto"> <div class="google-auth-button" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_google-auth-button" data-tracking-client-ingraph> <code id="isTermsAndConditionsSkipEnabledAuthButton" style="display: none"></code> <p class="linkedin-tc__text text-color-text-low-emphasis text-xs pb-2" data-impression-id="public_post_contextual-sign-in-modal_sign-in-modal__button-skip-tc-text"> En cliquant sur Continuer pour vous inscrire ou vous identifier, vous acceptez les <a href="/legal/user-agreement?trk=public_post_contextual-sign-in-modal_sign-in-modal_auth-button_user-agreement" target="_blank" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_auth-button_user-agreement" data-tracking-will-navigate="true">Conditions d’utilisation</a>, la <a href="/legal/privacy-policy?trk=public_post_contextual-sign-in-modal_sign-in-modal_auth-button_privacy-policy" target="_blank" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_auth-button_privacy-policy" data-tracking-will-navigate="true">Politique de confidentialité</a> et la <a href="/legal/cookie-policy?trk=public_post_contextual-sign-in-modal_sign-in-modal_auth-button_cookie-policy" target="_blank" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_auth-button_cookie-policy" data-tracking-will-navigate="true">Politique relative aux cookies</a> de LinkedIn. </p> <div class="google-auth-button__placeholder google-auth-button__placeholder--black-border" data-theme="outline" data-logo-alignment="center"></div>  </div> </div>  <p class="sign-in-modal__join-now m-auto font-sans text-md text-color-text mt-2"> Nouveau sur LinkedIn ? <a href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Ffr%2Elinkedin%2Ecom%2Fposts%2Fd2r-dna-to-rna_this-morning-we-had-the-privilege-of-hosting-activity-7262914383423451137-51i7&trk=public_post_contextual-sign-in-modal_sign-in-modal_join-link" data-tracking-control-name="public_post_contextual-sign-in-modal_sign-in-modal_join-link" data-tracking-will-navigate="true" class="sign-in-modal__join-link">Inscrivez-vous maintenant</a> </p> </div> </div>  </section> </div> </div> </div> </div> <div class="contextual-sign-in-modal__divider left-right-divider"> <p class="contextual-sign-in-modal__divider-text font-sans text-sm text-color-text px-2"> ou </p> </div> </div> <p class="contextual-sign-in-modal__join-now m-auto font-sans text-md text-color-text my-1"> Nouveau sur LinkedIn ? <a href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Ffr%2Elinkedin%2Ecom%2Fposts%2Fd2r-dna-to-rna_this-morning-we-had-the-privilege-of-hosting-activity-7262914383423451137-51i7&trk=public_post_contextual-sign-in-modal_join-link" data-tracking-control-name="public_post_contextual-sign-in-modal_join-link" data-tracking-will-navigate="true" class="contextual-sign-in-modal__join-link">Inscrivez-vous maintenant</a> </p> <p class="linkedin-tc__text text-color-text-low-emphasis text-xs pb-2 contextual-sign-in-modal__terms-and-conditions m-auto w-[320px] pt-2 babybear:w-full" data-impression-id="linkedin-tc__button-skip-tc-text"> En cliquant sur Continuer pour vous inscrire ou vous identifier, vous acceptez les <a href="/legal/user-agreement?trk=linkedin-tc_auth-button_user-agreement" target="_blank" data-tracking-control-name="linkedin-tc_auth-button_user-agreement" data-tracking-will-navigate="true">Conditions d’utilisation</a>, la <a href="/legal/privacy-policy?trk=linkedin-tc_auth-button_privacy-policy" target="_blank" data-tracking-control-name="linkedin-tc_auth-button_privacy-policy" data-tracking-will-navigate="true">Politique de confidentialité</a> et la <a href="/legal/cookie-policy?trk=linkedin-tc_auth-button_cookie-policy" target="_blank" data-tracking-control-name="linkedin-tc_auth-button_cookie-policy" data-tracking-will-navigate="true">Politique relative aux cookies</a> de LinkedIn. </p> </div> </div>  </section> </div> </div> </div> </div>  <code id="activityUrn" style="display: none"></code> <div id="toasts" class="toasts fixed z-8 babybear:right-4 mamabear:right-4 papabear:min-h-[96px] invisible top:auto bottom-4 left-4 papabear:w-[400px] toasts--bottom" type="bottom"> <template id="toast-template"> <div class="toast container-raised flex toast--bottom transition ease-accelerate duration-xxslow " data-id="toast"> <div class="toast__message flex flex-1 babybear:items-center mamabear:items-center papabear:items-start py-2 px-1.5" data-id="toast__message" role="alert" tabindex="-1"> <div class="toast__message-content-container" data-id="toast__message-content-container"> <p class="toast__message-content font-sans text-sm opacity-90 inline babybear:self-center mamabear:self-center papabear:self-start" data-id="toast__message-content"></p> </div> </div> <button class="toast__dismiss-btn cursor-pointer babybear:self-center mamabear:self-center papabear:self-start pt-3 pb-2 papabear:py-2 pl-0.5 pr-0" data-id="toast__dismiss-btn" aria-label="Fermer"> <svg width="24" height="24" class="fill-color-icon"><path d="M13 4.32 9.31 8 13 11.69 11.69 13 8 9.31 4.31 13 3 11.69 6.69 8 3 4.31 4.31 3 8 6.69 11.68 3Z"></path></svg> </button> </div> </template> <template id="toast-icon-caution"> <icon class="text-color-icon-caution toast__icon w-3 h-3 shrink-0 mr-2" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/u6kgm8vi5s4rhtbgmjlphlp6"></icon> </template> <template id="toast-icon-error"> <icon class="text-color-icon-negative toast__icon w-3 h-3 shrink-0 mr-2" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/2ffvlzyh9wb65459t9va8w2ph"></icon> </template> <template id="toast-icon-gdpr"> <icon class="text-color-icon-neutral toast__icon w-3 h-3 shrink-0 mr-2" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/a0d85elrpgg38lskvq1kvzb3"></icon> </template> <template id="toast-icon-notify"> <icon class="text-color-icon-neutral toast__icon w-3 h-3 shrink-0 mr-2" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/de23f5me7dfm17unsj9up4vga"></icon> </template> <template id="toast-icon-success"> <icon class="text-color-icon-positive toast__icon w-3 h-3 shrink-0 mr-2" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/c44ryoszao52cyd0y87z7s0uf"></icon> </template> <template id="toast-cta"> <a class="toast__cta cta-link font-medium ml-0.5 text-sm text-inherit inline" target="_blank"></a> </template> </div> <script 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D2R | de l'ADN à l'ARN sur LinkedIn : This morning, we had the privilege of hosting an insightful Breakfast &…