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He is a professor of chemistry at the [[University of Copenhagen]]<ref>{{cite web |title=Morten Meldal is the new professor in nanochemistry |publisher=Nano- Science Center |date=7 February 2011 |url=http://nano.ku.dk/english/news/meldal_040211/ |access-date=4 April 2014 |archive-date=16 August 2011 |archive-url=https://web.archive.org/web/20110816160605/http://nano.ku.dk/english/news/meldal_040211/ |url-status=live}}</ref> in [[Copenhagen]], Denmark. He is best known for developing the [[Azide-alkyne Huisgen cycloaddition|CuAAC-click reaction]],<ref>Tornøe, C.W. and Meldal, M., Peptidotriazoles: Copper(I)-catalyzed 1,3-dipolar cycloadditions on solid-phase. In: Lebl, M., Houghten, R.A. (Eds.), American Peptide Society and Kluwer Academic Publishers, San Diego, 2001, pp. 263–4.</ref><ref>{{Cite book |editor-last1=Yan |editor-first1=Bing |editor-last2=Czarnik |editor-first2=Anthony W. |title=Optimization of Solid-Phase Combinatorial Synthesis |chapter-url=https://books.google.com/books?id=agNyY9m93X0C&q=Meldal%2CM.%2C+PEGA%3A+A+flow+stable+polyethylene+glycol+dimethyl+acrylamide+copolymer+for+solid+phase+synthesis%2C+Tetrahedron+Lett.%2C+33+%281992%29+3077-3080&pg=PA105 |access-date=5 April 2014 |edition=1 |publisher=CRC Press |location=United States |page=408 |chapter=five |date=4 December 2001 |isbn=978-0-8247-0654-8 |archive-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005095437/https://books.google.com/books?id=agNyY9m93X0C&q=Meldal,M.,+PEGA:+A+flow+stable+polyethylene+glycol+dimethyl+acrylamide+copolymer+for+solid+phase+synthesis,+Tetrahedron+Lett.,+33+(1992)+3077-3080&pg=PA105 |url-status=live}} and Meldal, M., Peptidotriazoles on solid-phase.</ref> concurrently with but independent of Valery V. Fokin and [[K. Barry Sharpless]].<ref>{{cite journal |last1=Rostovtsev |first1=Vsevolod V. |last2=Green |first2=Luke G |last3=Fokin |first3=Valery V. |last4=Sharpless |first4=K. Barry |title=A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective "Ligation" of Azides and Terminal Alkynes |journal=Angewandte Chemie International Edition |year=2002 |volume=41 |issue=14 |pages=2596–2599 |doi=10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4 |pmid=12203546}}</ref> == Biography == Meldal received [[Bachelor of Science|B.S.]] and PhD degrees in [[Chemical Engineering|chemical engineering]] from [[Technical University of Denmark]] (DTU); his PhD work was supervised by Klaus Bock and focused on the synthetic chemistry of carbohydrates.<ref>{{cite web |url=https://www.eurpepsoc.com/2022-nobel-prize-in-chemistry-awarded-to-morten-meldal/ |title=2022 Nobel Prize in Chemistry awarded to Morten Meldal |publisher=The European Peptide Society |date=8 October 2022 |access-date=12 October 2022 |archive-date=12 October 2022 |archive-url=https://web.archive.org/web/20221012090616/https://www.eurpepsoc.com/2022-nobel-prize-in-chemistry-awarded-to-morten-meldal/ |url-status=live }}</ref> From 1983 to 1988 he was a postdoctoral fellow in organic chemistry, first at the DTU, next at the [[MRC Laboratory of Molecular Biology]] at [[Cambridge University]]<ref>{{cite web |title=LMB Alumni |publisher=MRC Laboratory of Molecular Biology |url=http://www2.mrc-lmb.cam.ac.uk/about-lmb/archive-and-alumni/alumni/ |access-date=4 April 2014 |archive-url=https://web.archive.org/web/20190801005623/http://www2.mrc-lmb.cam.ac.uk/about-lmb/archive-and-alumni/alumni/ |archive-date=1 August 2019}}</ref> and then at the [[University of Copenhagen]].<ref>{{cite web |url=https://chem.ku.dk/ansatte/alle/?pure=en%2Fpersons%2Fmorten-peter-meldal(1e2eefb3-1cc1-4626-8565-a83631fc05fd)%2Fcv.html |title=Morten Peter Meldal |date=27 August 2007 |access-date=12 October 2022 |archive-date=12 October 2022 |archive-url=https://web.archive.org/web/20221012084910/https://chem.ku.dk/ansatte/alle/?pure=en%2Fpersons%2Fmorten-peter-meldal%281e2eefb3-1cc1-4626-8565-a83631fc05fd%29%2Fcv.html |url-status=live }}</ref> In 1996 he was appointed assistant professor at DTU. Since 1998 he has led the synthesis group in the Department of Chemistry of the [[Carlsberg Laboratory]].<ref>{{cite journal |last1=Rademann |first1=Jorg |title=SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase |journal=Journal of the American Chemical Society |volume=23 |issue=121 |pages=5459–5466 |date=29 May 1999 |doi=10.1021/ja984355i}}</ref><!-- and since 1997, he has served as head of the Solid-Phase Organic Chemistry and Enzymatic Reaction Center (SPOCC). --> Meldal developed several technological techniques and instruments for peptide synthesis near the start of his career. He developed the multiple-column synthesis used in peptide and organic synthesis instruments, as well as for assembling large split-mix libraries. He first presented the cycloaddition of acetylenes and azides used in peptide and protein conjugations, in polymers and in material sciences. Meldal's group has then showed this reaction to be orthogonal to the majority of functional group chemistries.<ref>{{cite journal |title=Simultaneous 'One Pot' Expressed Protein Ligation and CuI-Catalyzed Azide/Alkyne Cycloaddition for Protein Immobilization |last1=Steinhagen |first1=Max |last2=Holland-Nell |first2=Kai |last3=Meldal |first3=Morten |last4=Beck-Sickinger |first4=Annette G. |journal=ChemBioChem |year=2011 |volume=12 |issue=16 |pages=2426–2430 |doi=10.1002/cbic.201100434 |pmid=21901810 |s2cid=44986511}}</ref><!-- They later developed solid supports that have facilitated the merger of solid phase peptide- and peptide-organic chemistry with solid phase chemical biology and protein chemistry. --> More recently Meldal has developed an optical encoding technique<ref>{{cite journal |title=Sustainable Flow Synthesis of Encoded Beads for Combinatorial Chemistry and Chemical Biology |last1=Hu |first1=Hongxia |last2=Nikitin |first2=Sergei |last3=Berthelsen |first3=Adam Bjørnholdt |last4=Diness |first4=Frederik |last5=Schoffelen |first5=Sanne |last6=Meldal |first6=Morten |journal=ACS Comb. Sci. |year=2018 |volume=20 |issue=8 |pages=492–498 |doi=10.1021/acscombsci.8b00052 |pmid=29969235 |s2cid=206543696}}</ref> and has focused on the merger of [[organic chemistry]] and peptide chemistry on solid support. He has devised a range of novel methods for the generation of N-acyl iminium ions in which combinatorial libraries of these compounds are generated and screened for substances with activity toward [[G protein-coupled receptor|G protein-coupled receptors]] in cell-based on-bead screening.<ref>{{cite journal |title=Solid-Phase Synthesis of Tetrahydro-β-carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N-Carbamyliminium Pictet–Spengler Reactions |last1=Diness |first1=Frederik |last2=Beyer |first2=Jürgen |last3=Meldal |first3=Morten |journal=Chemistry – A European Journal |year=2006 |volume=12 |issue=31 |pages=8056–8066 |doi=10.1002/chem.200600138 |pmid=16881029}}</ref> In 2019, Meldal co-founded the company Betamab Therapeutics ApS, based on the concept of beta-bodies, i.e. peptide mimics of [[antibodies]].<ref>{{cite journal |last1=Hu |first1=Hongxia |last2=Kofoed |first2=Christian |last3=Li |first3=Ming |last4=Gonçalves |first4=Juliana P.L. |last5=Hansen |first5=Jonas |last6=Wolfram |first6=Martin |last7=Hansen |first7=Axel K. |last8=Hartmann |first8=Camilla H.F. |last9=Diness |first9=Frederik |last10=Schoffelen |first10=Sanne |last11=Meldal |first11=Morten |title=Computational Evolution of Threonine-Rich β-Hairpin Peptides Mimicking Specificity and Affinity of Antibodies |journal=ACS Central Science |year=2019 |volume=5 |issue=2 |pages=259–269 |doi=10.1021/acscentsci.8b00614 |pmc=6396188 |pmid=30834314}}</ref> The company closed in 2021.<ref>{{cite web |title=Betamab ApS |publisher=Paqle |url=https://profiler.tv2lorry.dk/betamab-aps-1894397 |access-date=10 December 2021 |archive-date=10 December 2021 |archive-url=https://web.archive.org/web/20211210210313/https://profiler.tv2lorry.dk/betamab-aps-1894397 |url-status=live}}</ref> == Honors and awards == Meldal was awarded the 2022 [[Nobel Prize in Chemistry]], jointly with [[Carolyn R. Bertozzi]] and [[Karl Barry Sharpless]], "for the development of click chemistry and [[bioorthogonal chemistry]]".{{r|nobelprize}} <!-- ==Achievements== {{More citations needed section|date=October 2022}} * Meldal has developed a wide range of [[chemical technology|chemical technologies]] based on temporary protection schemes for [[glycopeptide]] synthesis, including linked glycopeptides, that were used in characterisation of the immunological response to cancer- related [[mucin]]s. A concept of using template based glycopeptide mimetics is currently employed in biochemical studies. * Developed [[solid phase synthesis]] of combinatorial libraries of peptides containing [[phosphinic acid]] as transition state analogues and identified [[nanomolar]] selective inhibitors for [[metalloproteases]] involved in [[osteoclast]] migration towards the control of [[osteoporosis]]. * Developed the concept of organozymes and peptide-based cage-like receptors that recognise, e.g., sugar water. * Introduced a solid phase synthesis technique that allows clean activation. --><!-- == Awards and honours == {{More citations needed section|date=October 2022}} * Nobel Prize in Chemistry 2022 * ''Kirstine Meyers Award'' (Denmark) (1988) * ''Danish Society of Chemistry Award'' (1990) * ''research award'' from the EU-Science Program (Belgium) (1992) * ''travel award'' from [[NATO]] (1992) * ''research award'' from the Mitzutani Foundation (Japan) (1995) * ''NKT Award'' from the Chemical Society of Denmark (1996) * ''Leonidas Zervas Award'' from the European Peptide Society (1996) * ''research award'' from the EU-INCO-DC program (1996) * ''Niels Bjerrum Gold Medal in Chemistry'' (1997) * ''research award'' from the Danish National Research Foundation (1997) * ''research award'' from the Danish Cancer Society (1997) * Presented the ''Bjerrum-Brønsted-Lang Lecture'' at the [[Royal Danish Academy of Sciences and Letters]] (1999) * Received the ''Ralph F. Hirschmann Award in Peptide Chemistry'' from the [[American Chemical Society]] (2009)<ref>{{cite news |last1=Lubell |first1=William D. |title=Morten P. Meldal, 2009 Ralph F. Hirschmann Awardee, Follows in Hirschmann's Footsteps |newspaper=American Peptide Society Newsletter |pages=1–2 |date=Spring 2010 |url=http://americanpeptidesociety.org/documents/newsletters/newsletter_30.pdf |access-date=4 April 2014}}</ref> * Co-founder and chairman of the Society of Combinatorial Sciences (SCS) * Member of the Danish National Academy * Member of the editorial board of ''[[Journal of Combinatorial Chemistry]]'' * Member of the editorial board of ''ChemBioChem'' journal. His group has published over 250 articles and have filed 20 patents covering areas both in organic and bioorganic chemistry. --> == References == {{Reflist|refs= <ref name="nobelprize">{{Cite press release |url=https://www.nobelprize.org/prizes/chemistry/2022/press-release/ |title=Press release: The Nobel Prize in Chemistry 2022 |publisher=Nobel Foundation |date=5 October 2022 |access-date=5 October 2022 |archive-url=https://web.archive.org/web/20221005095715/https://www.nobelprize.org/prizes/chemistry/2022/press-release/ |archive-date=5 October 2022}}</ref> }} == External links == {{Scholia}} * {{Nobelprize}} {{Nobel Prize in Chemistry Laureates 2001–2025}} {{2022 Nobel Prize winners}} {{Authority control}} {{DEFAULTSORT:Meldal, Morten P.}} [[Category:Danish chemists]] [[Category:1954 births]] [[Category:Living people]] [[Category:Carlsberg Laboratory staff]] [[Category:Nobel laureates in Chemistry]] [[Category:Technical University of Denmark alumni]] [[Category:Academic staff of the 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