Recombinant Human IL-10 GMP Protein, CF (1064-GMP) by R&D Systems, Part of Bio-Techne

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class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup 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data-time_datapoints="-0.1316339969635" data-time_template="0.1316339969635" data-time_post_epcc="0.65276408195496" data-time_epcc="-0.1316339969635" data-render_time="Monday 25th of November 2024 09:06:06 AM" data-fallback="FALSE" data-time_to_process_data="0.093661069869995" class="px-4 container" class="container"> <div id="above-fold-section"> <div class="mb-2 o__product-summary"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> Recombinant Human IL-10 GMP Protein, CF <span id="gmp-icon"> <span class="a___badge-gmp badge text-white align-middle p-1" title="GMP Product">GMP</span> </span> </h1> <h2 class="font-weight-normal h4"> R&D Systems, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">1064-GMP</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div id="submit_review_wrapper" class="col-auto d-flex align-self-center"> <div id="submit_review"> <a href="/reviews/1064-GMP" class="submit_review" rel="nofollow"> <span class="icon-plus-circle d-none d-lg-inline pr-1"></span> Submit a review </a> </div> </div> <div class="col-auto d-flex align-self-center"> <div> <div class="px-0 my-1" id="datasheet-summary-wrapper" data-section="section-base--top-jumplink"> <article class="top-jumplink-wrapper"> <span class="icon-icon-pdf text-error-red"></span> <a href="#product-documents" class="product-documents-top-link" rel="nofollow">Product Datasheet / COA / SDS</a> </article> </div> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> Animal Free </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" alt="R&D Systems, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> <div class="row border-top mb-2" id="images-orderdetail-wrapper"> <div class="col-xl-6 mt-2" id="images-wrapper" data-section="image_summary"> <div id="image-tree" data-section="component-product-image-tree" class="vertical lightbox" data-mdb-zoom-effect="true"> <div id="product-image-gallery" class="row"> <div class="col-md-2 d-none d-md-block"> <ul class="list-inline m-0"> <li data-id="1" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/protein/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-sds-page-1082021151227.jpg" data-srcset="https://resources.bio-techne.com/images/products/protein/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-sds-page-1082021151227.jpg" alt="" title="GMP-grade Recombinant Human IL-10 Protein SDS-Page" data-caption="2 μg/lane of GMP-grade Recombinant Human IL-10 Protein (1064-GMP) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 18 kDa and 16 kDa, respectively." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/protein/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-sds-page-1082021151227.jpg" data-id="0" data-application="https://resources.bio-techne.com/images/products/protein/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-sds-page-1082021151227.jpg" class="lazy" /> </div> </li> <li data-id="2" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-24820239194..jpg" data-srcset="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-24820239194..jpg" alt="Purity consistency of GMP Human IL-10 Protein" title="Recombinant Human IL-10 GMP Protein Purity Analysis by Size Separation." data-caption="Three independent lots of Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) were analyzed by Maurice CE-SDS PLUS (IS is an Internal Standard). A gel-like representation of the purity analysis data (inset) can be obtained from the Lane View feature in Compass software for iCE. Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-24820239194..jpg" data-id="1" data-application="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-24820239194..jpg" class="lazy" /> </div> </li> <li data-id="3" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-1392023122142..png" data-srcset="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-1392023122142..png" alt="Charge consistency of GMP Human IL-10 Protein" title="Recombinant Human IL-10 GMP Protein Purity Analysis by Charge Variation." data-caption="Three independent lots of Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) were analyzed by Maurice icIEF using native fluorescence detection (Mkr 5.85 and 9.99 are pI Markers). Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-1392023122142..png" data-id="2" data-application="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-1392023122142..png" class="lazy" /> </div> </li> </ul> </div> <div class="col-md-10 border rounded d-flex align-items-center justify-content-center product-image-lightbox"> <div class="text-center my-2" data-brand="rnd"> <img src="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-bioactivity-118202114505.jpg" alt="" title="GMP-grade Recombinant Human IL-10 Protein Bioactivity" data-caption="GMP-grade Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) was measured in a cell proliferation assay using MC/9-2 mouse mast cells. The ED<sub>50</sub> for this effect is 0.0750-0.750 ng/mL. Three independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of GMP IL-10." data-badges='' data-id="0" width="250" height="250" fetchpriority="high" as="image" class="search_result_thumbnail_image active" /> </div> </div> </div> </div> </div> <div class="col-xl-6 mt-2" id="orderdetails-wrapper" data-section="order_detail_block"> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="1064-GMP"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-3 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart" class="atc-lines"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="1064-GMP-01M" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">1064-GMP-01M</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="1064-GMP-050" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">1064-GMP-050</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> <div class="atc-control ProductCart-control text-right"> <div class="row container d-flex justify-content-end mx-0 mb-3 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="" class="atc-print-quote-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100">Print Quote</a> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=1064-GMP" class="atc-bulk-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> <div 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Storage</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#background"> Background</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#product-documents"> Product Documents</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#manufacturing-specifications"> Manufacturing Specifications</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#specific-notices"> Specific Notices</a> </li> </ul> </div> <div id="key_details" class="py-5 bt-pp-border-bottom" data-section="section-base--key-details"> <h3>Key Product Details</h3> <div class="row mt-5"> <div class="col-sm-12"> <ul> <li>IL-10 Manufactured in Bio-Techne's new GMP facility</li> <li>Lot-to-lot consistency</li> <li>Stringent guidelines for patient safety</li> <li>Scalability necessary to support successful therapeutics</li> <li>Learn more about manufacturing in <a href="https://www.bio-techne.com/gmp-manufacturing-facility" target="_blank">our new GMP facility</a></li> <li>Test it in your process! <a href="https://www.bio-techne.com/gmp-products/gmp-proteins/sample-gmp-proteins">Request a sample of GMP IL-10</a></li> </ul> </div> </div> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> E. coli </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Accession #</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <a href="https://www.ncbi.nlm.nih.gov/protein/P22301.1" class="a___link-external" target="_blank" rel="nofollow">P22301.1</a> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Structure / Form</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Noncovalently-linked homodimer </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Conjugate</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Unconjugated </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Applications</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Bioactivity </div> </div> </div> <div class="container"> <div class="row product-data"> <div class="col-lg-6 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4><a href="/t/il-10/proteins-enzymes">View all IL-10 Proteins and Enzymes »</a></h4> </div> </div> </div> </div> <div class="border-top border-bottom recommended-products-section" id="recommendation-viewed" data-product_code="1064-GMP" data-type=viewed></div> <div id="product-specifications" class="bt-pp-border-bottom py-5" data-section="section-base--product-specifications"> <h3>Product Specifications</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <em>E. coli</em>-derived human IL-10 protein<br>Ser19-Asn178, with an N-terminal Met<br>Produced using non-animal reagents in an animal-free laboratory. <br>Manufactured and tested under cGMP guidelines. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Purity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> >97%, by SDS-PAGE with quantitative densitometry by Coomassie® Blue Staining. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Endotoxin Level</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <0.10 EU per 1 μg of the protein by the LAL method. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>N-terminal Sequence Analysis</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Met-Ser19-Pro-Gly-Gln-Gly-Thr-Gln-Ser-Glu </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Predicted Molecular Mass</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> 19 kDa </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>SDS-PAGE</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> 18 kDa, reducing conditions </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Activity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Measured in a cell proliferation assay using MC/9-2 mouse mast cells. Thompson-Snipes, L. <EM>et al</EM>. (1991) J. Exp. Med. <STRONG>173</STRONG>:507.<br />The ED<sub>50</sub> for this effect is 0.0750-0.750 ng/mL.</p><p>The specific activity of recombinant human IL-10 is >2.50 x 10<sup>6</sup> units/mg, which is calibrated against the human IL-10 WHO Reference Reagent (NIBSC code: 93/722). </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Host Cell Protein</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <0.500 ng per μg of protein when tested by ELISA. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Mycoplasma</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Negative for Mycoplasma. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Host Cell DNA</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <0.00150 ng per µg of protein when tested by PCR. </div> </div> </div> </div> <div id="scientific-data" class="bt-pp-border-bottom py-5" data-anchor-label="Scientific Data" data-section="section-base--scientific-data"> <div> <h3>Scientific Data Images for Recombinant Human IL-10 GMP Protein, CF </h3> </div> <div class="product-data-wrapper mt-5" id="scientific-data-table" data-scientific-count="1"> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-bioactivity-118202114505.jpg" data-srcset="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-bioactivity-118202114505.jpg" alt="" title="GMP-grade Recombinant Human IL-10 Protein Bioactivity" data-caption="GMP-grade Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) was measured in a cell proliferation assay using MC/9-2 mouse mast cells. The ED<sub>50</sub> for this effect is 0.0750-0.750 ng/mL. Three independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of GMP IL-10." data-badges="" data-application="Bioactivity" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">GMP-grade Recombinant Human IL-10 Protein Bioactivity</h4> GMP-grade Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) was measured in a cell proliferation assay using MC/9-2 mouse mast cells. The ED<sub>50</sub> for this effect is 0.0750-0.750 ng/mL. Three independent lots were tested for activity and plotted on the same graph to show lot-to-lot consistency of GMP IL-10. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/protein/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-sds-page-1082021151227.jpg" data-srcset="https://resources.bio-techne.com/images/products/protein/1064-gmp_recombinant-human-il-10-aa-19-178-gmp-protein-cf-sds-page-1082021151227.jpg" alt="" title="GMP-grade Recombinant Human IL-10 Protein SDS-Page" data-caption="2 μg/lane of GMP-grade Recombinant Human IL-10 Protein (1064-GMP) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 18 kDa and 16 kDa, respectively." data-badges="" data-application="SDS-Page" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">GMP-grade Recombinant Human IL-10 Protein SDS-Page</h4> 2 μg/lane of GMP-grade Recombinant Human IL-10 Protein (1064-GMP) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 18 kDa and 16 kDa, respectively. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-24820239194..jpg" data-srcset="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-24820239194..jpg" alt="Purity consistency of GMP Human IL-10 Protein" title="Recombinant Human IL-10 GMP Protein Purity Analysis by Size Separation." data-caption="Three independent lots of Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) were analyzed by Maurice CE-SDS PLUS (IS is an Internal Standard). A gel-like representation of the purity analysis data (inset) can be obtained from the Lane View feature in Compass software for iCE. Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges="" data-application="Data" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-10 GMP Protein Purity Analysis by Size Separation.</h4> Three independent lots of Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) were analyzed by Maurice CE-SDS PLUS (IS is an Internal Standard). A gel-like representation of the purity analysis data (inset) can be obtained from the Lane View feature in Compass software for iCE. Profiles from the three runs were superimposed, showing excellent manufacturing consistency. </div> </div> </div> <span class="product-data-wrapper table" id="more-scientific-data" style="display:none"> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-1392023122142..png" data-srcset="https://resources.bio-techne.com/images/products/1064-gmp_recombinant-human-il-10-gmp-protein-cf-data-1392023122142..png" alt="Charge consistency of GMP Human IL-10 Protein" title="Recombinant Human IL-10 GMP Protein Purity Analysis by Charge Variation." data-caption="Three independent lots of Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) were analyzed by Maurice icIEF using native fluorescence detection (Mkr 5.85 and 9.99 are pI Markers). Profiles from the three runs were superimposed, showing excellent manufacturing consistency." data-badges="" data-application="Data" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human IL-10 GMP Protein Purity Analysis by Charge Variation.</h4> Three independent lots of Recombinant Human IL-10 GMP Protein (Catalog # 1064-GMP) were analyzed by Maurice icIEF using native fluorescence detection (Mkr 5.85 and 9.99 are pI Markers). Profiles from the three runs were superimposed, showing excellent manufacturing consistency. </div> </div> </span> <div class="row"> <div class="col-md-2"> <a id="scientific-view-more" class="more"> View 1 more images </a> </div> </div> </div> </div> <div id="preparation--storage" class="bt-pp-border-bottom py-5" data-section="section-protein--preparation-storage"> <h3>Formulation, Preparation and Storage</h3> <div class="datasheet_section"> <div class="row px-3"> <div class="col-xs-12 "> <div class="border-left border-right border-top text-center"> <h5 class="m-0 p-3 bg-dark-bt-blue text-white"> 1064-GMP </h5> </div> <table class="ds_table_html table-bordered tablesaw tablesaw-stack"> <tbody> <tr> <td class="font-weight-bold">Formulation</td> <td class="w-75">Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.</td> </tr> <tr> <td class="font-weight-bold">Reconstitution</td> <td class="w-75">Reconstitute at 100-500 μg/mL in PBS.</td> </tr> <tr> <td class="font-weight-bold">Shipping</td> <td class="w-75">The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="font-weight-bold">Stability & Storage</td> <td class="w-75"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>A minimum of 12 months when stored at ≤ -20 °C as supplied. Refer to lot specific COA for the Use by Date. </LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>3 months, ≤ -20 °C under sterile conditions after reconstitution.</LI></UL></td> </tr> </tbody> </table> </div> </div> </div> </div> <div id="background" class="py-5 bt-pp-border-bottom" data-section="section-base--background-info"> <h3>Background: IL-10</h3> <article class="product-data-wrapper"> Interleukin 10, also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL‑10 family of alpha‑helical cytokines that also includes IL‑19, IL‑20, IL‑22, IL‑24, and IL‑26/AK155 (1, 2). IL‑10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts (2 ‑ 5). Mature human IL‑10 shares 72% ‑ 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL‑10. Whereas human IL‑10 is active on mouse cells, mouse IL‑10 does not act on human cells (6, 7). IL‑10 is a 178 amino acid molecule that contains two intrachain disulfide bridges and is expressed as a 36 kDa noncovalently associated homodimer (6, 8, 9). The IL‑10 dimer binds to two IL‑10 R alpha/IL‑10 R1 chains, resulting in recruitment of two IL‑10 R beta/IL‑10 R2 chains and activation of a signaling cascade involving JAK1, TYK2, and STAT3 (10). IL‑10 R beta does not bind IL‑10 by itself but is required for signal transduction (1). IL‑10 R beta also associates with IL‑20 R alpha, IL‑22 R alpha, or IL‑28 R alpha to form the receptor complexes for IL‑22, IL‑26, IL‑28, and IL‑29 (11 ‑ 13). IL‑10 is a critical molecule in the control of viral infections and allergic and autoimmune inflammation (14 ‑ 16). It promotes phagocytic uptake and Th2 responses but suppresses antigen presentation and Th1 proinflammatory responses (2). </article> <div id="background_wrapper" class="px-3 mt-2"> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>References</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <OL> <LI>Pestka, S. <EM>et al</EM>. (2004) Annu. Rev. Immunol. <STRONG>22</STRONG>:929.</LI> <LI>Sabat, R. <EM>et al</EM>. (2010) Cytokine Growth Factor Rev. <STRONG>21</STRONG>:331.</LI> <LI>Mathurin, P. <EM>et al</EM>. (2002) Am. J. Physiol. Gastrointest. Liver Physiol. <STRONG>282</STRONG>:G981.</LI> <LI>Grewe, M. <EM>et al</EM>. (1995) J. Invest. Dermatol. <STRONG>104</STRONG>:3.</LI> <LI>Szony, B.J. <EM>et al</EM>. (1999) Mol. Hum. Reprod. <STRONG>5</STRONG>:1059.</LI> <LI>Vieira, P. <EM>et al</EM>. (1991) Proc. Natl. Acad. Sci. <STRONG>88</STRONG>:1172.</LI> <LI>Hsu, D.-H. <EM>et al</EM>. (1990) Science <STRONG>250</STRONG>:830.</LI> <LI>Windsor, W.T. <EM>et al</EM>. (1993) Biochemistry <STRONG>32</STRONG>:8807.</LI> <LI>Syto, R. <EM>et al</EM>. (1998) Biochemistry <STRONG>37</STRONG>:16943.</LI> <LI>Kotenko, S.V. <EM>et al</EM>. (1997) EMBO J. <STRONG>16</STRONG>:5894.</LI> <LI>Kotenko, S.V. <EM>et al</EM>. (2000) J. Biol. Chem. <STRONG>276</STRONG>:2725.</LI> <LI>Hor, S. <EM>et al</EM>. (2004) J. Biol. Chem. <STRONG>279</STRONG>:33343.</LI> <LI>Sheppard, P. <EM>et al</EM>. (2003) Nat. Immunol. <STRONG>4</STRONG>:63.</LI> <LI>Fitzgerald, D.C. <EM>et al</EM>. (2007) Nat. Immunol. <STRONG>8</STRONG>:1372.</LI> <LI>Wu, K. <EM>et al</EM>. (2007) Cell. Mol. Immunol. <STRONG>4</STRONG>:269.</LI> <LI>Blackburn, S.D. and E.J. Wherry (2007)Trends Microbiol. <STRONG>15</STRONG>:143.</LI></OL> </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Long Name</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> Interleukin 10 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Alternate Names</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> CSIF, GVHDS, IL10, IL10A, TGIF </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Entrez Gene IDs</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.ncbi.nlm.nih.gov/gene?term=3586" class="a___link-external" target="_blank" rel="nofollow">3586</a> (Human); <a href="https://www.ncbi.nlm.nih.gov/gene?term=16153" class="a___link-external" target="_blank" rel="nofollow">16153</a> (Mouse); <a href="https://www.ncbi.nlm.nih.gov/gene?term=25325" class="a___link-external" target="_blank" rel="nofollow">25325</a> (Rat); <a href="https://www.ncbi.nlm.nih.gov/gene?term=397106" class="a___link-external" target="_blank" rel="nofollow">397106</a> (Porcine); <a href="https://www.ncbi.nlm.nih.gov/gene?term=403628" class="a___link-external" target="_blank" rel="nofollow">403628</a> (Canine); <a href="https://www.ncbi.nlm.nih.gov/gene?term=102133450" class="a___link-external" target="_blank" rel="nofollow">102133450</a> (Cynomolgus Monkey); <a href="https://www.ncbi.nlm.nih.gov/gene?term=493683" class="a___link-external" target="_blank" rel="nofollow">493683</a> (Feline); <a href="https://www.ncbi.nlm.nih.gov/gene?term=100715618" class="a___link-external" target="_blank" rel="nofollow">100715618</a> (Guinea Pig); <a href="https://www.ncbi.nlm.nih.gov/gene?term=2949786" class="a___link-external" target="_blank" rel="nofollow">2949786</a> (Viral) </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Gene Symbol</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> IL10 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>UniProt</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.uniprot.org/uniprot/?query=P22301.1" class="a___link-external" target="_blank" rel="nofollow">P22301.1</a> </div> </div> </div> <h4 class="mt-3">Additional IL-10 Products</h4> <ul class="list-unstyled"> <li><a href="/t/il-10" data-product="IL-10">All Products for IL-10 </a></li> <li><a href="/t/il-10/cdna-clones" data-application="IL-10 cDNA Clones">IL-10 cDNA Clones </a></li> <li><a href="/t/il-10/elisa-kits" data-application="IL-10 ELISA Kits">IL-10 ELISA Kits </a></li> <li><a href="/t/il-10/elispot-fluorospot-kits" data-application="IL-10 ELISpot and FluoroSpot Kits">IL-10 ELISpot and FluoroSpot Kits </a></li> <li><a href="/t/il-10/luminex-assays" data-application="IL-10 Luminex Assays">IL-10 Luminex Assays </a></li> <li><a href="/t/il-10/lysates" data-application="IL-10 Lysates">IL-10 Lysates </a></li> <li><a href="/t/il-10/antibodies" data-application="IL-10 Primary Antibodies">IL-10 Primary Antibodies </a></li> <li><a href="/t/il-10/proteins-enzymes" data-application="IL-10 Proteins and Enzymes">IL-10 Proteins and Enzymes </a></li> <li><a href="/t/il-10/simple-plex" data-application="IL-10 Simple Plex">IL-10 Simple Plex </a></li> </ul> </div> <div id="product-documents" data-section="section-base--product-documents"> <div id="accordion" class="border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3"> Product Documents for Recombinant Human IL-10 GMP Protein, CF </h3> </div> <div class="vtab-section" data-section="Product Datasheets"> <div class="card-header rounded-top"> <a class="" data-toggle="collapse" data-target="#collapse_two" aria-expanded="true" aria-controls="collapse_two" id="product-datasheets-link"> <h5 class="mb-0"> Product Datasheets </h5> </a> </div> <div id="collapse_two" class="collapse show prod_datasheet_link" aria-labelledby="heading_two" data-parent="#accordion"> <div class="card-body"> <div class="row"> <div class="col-md-6"> <a href="https://resources.rndsystems.com/pdfs/datasheets/1064-gmp.pdf" class="datasheet_link" target="_blank" rel="nofollow">Download Product Datasheets</a> </div> </div> </div> </div> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" class="collapsed" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse " aria-labelledby="heading_one" data-parent="#accordion"> <div class="card-body"> <form novalidate="novalidate" data-drupal-selector="product-coa-form" action="#coa-form" method="post" id="product-coa-form" accept-charset="UTF-8"> <div class="row"> <div class="col-12"> <h2>Certificate of Analysis</h2> <p>To download a Certificate of Analysis, please enter a lot number in the search box below.</p> <p><strong>Note:</strong> Certificate of Analysis not available for kit components.</p> </div> </div> <section class="row"> <div class="col-md-6"> <form novalidate="novalidate" data-drupal-selector="product-coa-form"> <div class="form-row align-items-center"> <div class="col-md-10 my-1"> <input data-drupal-selector="form-dvsvfyrlhquzae5at58p6eh4tqyqhillf6x-sgdy6ow" type="hidden" name="form_build_id" value="form-DVSVfyRLHquZae5AT58p6EH4tqYQhIlLf6X-SGdY6Ow" /> <input data-drupal-selector="edit-product-coa-form" type="hidden" name="form_id" value="product_coa_form" /> <input data-drupal-selector="edit-product-code" type="hidden" name="product_code" value="1064-GMP" /> <div class="js-form-item form-item pb-3 js-form-type-textfield form-item-lot-number js-form-item-lot-number form-no-label"> <input autocomplete="off" class="form-control cofa-lookup form-text" id="lot-number" placeholder="Search by lot number" data-drupal-selector="edit-lot-number" type="text" name="lot_number" value="" size="60" maxlength="128" /> </div> <input data-drupal-selector="edit-brand" type="hidden" name="brand" value="rnd" /> <input data-drupal-selector="edit-document-category" type="hidden" name="document_category" value="coa" /> </div> <div class="col-auto mb-3"> <input id="edit-submit" class="btn btn-primary cofa-btn button js-form-submit form-submit" data-drupal-selector="edit-submit" type="submit" name="op" value="Submit" /> </div> </div> </form> </div> <div id="pdf-result-rnd" class="col-md-6 mb-4 pdf-result datasheet-loading"></div> </section> </form> </div> </div> <div class="card-header"> <a class="collapsed" data-toggle="collapse" data-target="#collapse_three" aria-expanded="false" aria-controls="collapse_three" > <h5 class="mb-0"> SDS </h5> </a> </div> <div id="collapse_three" class="collapse rounded-bottom" aria-labelledby="heading_three" data-parent="#accordion"> <div class="card-body"> <div class="row sds-row"> <div class="select_wrapper col"> <select class="sds_country_select dropdown-chevron form-control mb-2" data-uri="https://aero.bio-techne.com/sds/pdf/1064-gmp"> <option value="">Select SDS Language</option> <option value="cs-cz">Czech</option> <option value="da-dk">Danish</option> <option value="nl-nl">Dutch</option> <option value="en-us">English</option> <option value="de-de">German</option> <option value="fr-fr">French</option> <option value="hu-hu">Hungarian</option> <option value="it-it">Italian</option> <option value="nb-no">Norwegian</option> <option value="pl-pl">Polish</option> <option value="es-es">Spanish</option> <option value="sv-se">Swedish</option> </select> <span class="sds-pdf-result datasheet-loading"></span> </div> <div class="col my-3 pt-1 text-center text-lg-left"> <a class="sds-link datasheet_link datasheet-button-link text-wrap text-bt-blue" > Download SDS </a> </div> </div> </div> </div> </div> </div> <div id="manufacturing-specifications" class="py-5 bt-pp-border-bottom" data-section="section-base--manufacturing-specifications"> <h3>Manufacturing Specifications</h3> R&D Systems, a Bio-Techne Brand's GMP proteins are produced according to relevant sections of the following documents: USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and Eu. Ph. 5.2.12, Raw Materials of Biological Origin for the Production of Cell-based and Gene Therapy Medicinal Products. <br><br><br>R&D Systems' quality focus includes:<br><br><ul><li>Manufactured and tested under an ISO 9001:2015 and ISO 13485:2016 certified quality system</li><li>Documented processes and QA control of documentation and process changes</li><li>Personnel training programs</li><li>Raw material testing and vendor qualification/monitoring</li><li>Fully validated equipment, processes and test methods</li><li>Equipment calibration schedules using a computerized calibration program</li><li>Facility maintenance, safety programs and pest control</li><li>Material review process for variances</li><li>Monitoring of stability over product shelf-life</li></ul><br><br>R&D Systems strives to provide our customers with the analytical characteristics of each product so that customers may determine whether our products are appropriate for their research. The Certificate of Analysis provided contains the following lot specific information: <br><br><ul><li>N-terminal amino acid analysis, SDS-PAGE analysis, and endotoxin level (as determined by LAL assay) performed on each bulk QC lot, not on individual bottlings of each QC lot</li><li>Post-bottling lot-specific bioassay results (compliance with an established range) and results of microbial testing according to USP <71></li><li>Host Cell Protein testing performed by ELISA</li><li>Mycoplasma testing by ribosomal RNA hybridization assay</li></ul><br><br>Additional testing and documentation requested by the customer can be arranged at an additional cost.<br><br> Production records and facilities are available for examination by appropriate personnel on-site at R&D Systems. <br><br> R&D Systems sells GMP grade products for preclinical or clinical <em>ex vivo</em> cell therapy applications. They are not for <em>in vivo</em> use. Please read the following End User Terms prior to using this product.<br><br>Animal-Free Manufacturing Conditions<br> Our dedicated controlled-access animal-free laboratories ensure that at no point in production are the products exposed to potential contamination by animal components or byproducts. Every stage of manufacturing is conducted in compliance with R&D Systems' stringent Standard Operating Procedures (SOPs). Production and purification procedures use equipment and media that are confirmed animal-free.<br><br> Production<br><br><ul><li>All molecular biology procedures use animal-free media and dedicated labware.</li><li>Dedicated fermentors are utilized in committed animal-free areas.<br><br></li></ul> Purification<br><br><ul><li>Protein purification columns are animal-free.</li><li>Bulk proteins are filtered using animal-free filters.</li><li>Purified proteins are stored in animal-free containers in a dedicated cold storage room.</li></ul><br>Quality Assurance <br><br><ul><li>Low Endotoxin Level.</li><li>No impairment of biological activity. </li><li>High quality product obtained under stringent conditions. <br><br></li></ul><a target="_blank" href="https://www.rndsystems.com/products/animal-free-statement">Please read our complete Animal-Free Statement.</a> </div> <div id="specific-notices" class="py-5" data-section="section-base--specific-notices"> <h3>Product Specific Notices for Recombinant Human IL-10 GMP Protein, CF </h3> <p></p><p><b>END USER TERMS OF USE OF PRODUCT</b></p> <p>The following terms are offered to you upon your acceptance of these End User Terms of Use of Product. By using this product, you indicate your acknowledgment and agreement to these End User Terms of Use of Product. If you do not agree to be bound by and comply with all of the provisions of these End User Terms of Use of Product, you should contact your supplier of the product and make arrangements to return the product.</p> <p>We suggest you print and retain a copy of these End User Terms of Use of Product for your records.</p> <p>The End User is aware that R&D Systems, Inc. sells GMP products for preclinical or clinical <em>ex vivo</em> use and not for <em>in vivo</em> use. The End User further agrees, as a condition of the sale of R&D Systems' GMP products that: a) the End User will not use this GMP Product in any procedure wherein the product may be directly or indirectly administered to humans, unless the End User has obtained, or prior to their use will have obtained, an Investigational New Drug (IND) exemption from the FDA and will use the product only in accordance with the protocols of such IND and of the Institutional Review Board overseeing the proposed research, or b) the End User will use the products outside of the United States in accordance with the protocols of research approved by the Institutional Review Board or authorized ethics committee and regulatory agencies to which the End User is subject to in their territory.</p> <p>R&D Systems, Inc. has the right, at its sole discretion, to modify, add or remove any terms or conditions of these End User Terms of Use without notice or liability to you. Any changes to these End User Terms of Use are effective immediately following the printing of such changes on this product insert. The most recent version of these End User Terms of Use of Product may be found at: RnDSystems.com/Legal.</p> <p>You agree to review these End User Terms of Use of Product to ensure any subsequent use by you of R&D Systems' GMP Products following changes to these End User Terms of Use of Product constitutes your acceptance of all such changes.</p> <p> </p> <p><b>TERMS AND CONDITIONS</b></p> <p>The following limitation applies to R&D Systems' warranty and liability for damages: All products are warranted to meet R&D Systems' published specifications when used under normal laboratory conditions.</p> <p>R&D SYSTEMS DOES NOT MAKE ANY OTHER WARRANTY OR REPRESENTATION WHATSOEVER, WHETHER EXPRESS OR IMPLIED, WITH RESPECT TO ITS PRODUCTS. IN PARTICULAR, R&D SYSTEMS DOES NOT MAKE ANY WARRANTY OF SUITABILITY, NONINFRINGEMENT, MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE.</p> <p>NOTWITHSTANDING ANY OTHER PROVISIONS OF THESE TERMS AND/OR ANY OTHER AGREEMENT BETWEEN R&D SYSTEMS AND PURCHASER FOR THE PURCHASE OF THE PRODUCTS, R&D SYSTEMS' TOTAL LIABILITY TO PURCHASER ARISING FROM OR IN RELATION TO THESE TERMS, AN AGREEMENT BETWEEN THE PARTIES OR THE PRODUCTS, WHETHER ARISING IN CONTRACT, TORT OR OTHERWISE SHALL BE LIMITED TO THE TOTAL AMOUNT PAID BY PURCHASER TO R&D SYSTEMS FOR THE APPLICABLE PRODUCTS. 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Recombinant Human IL-10 GMP Protein, CF (1064-GMP) by R&D Systems, Part of Bio-Techne