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Nitroprussiate de sodium — Wikipédia

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id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 22 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-22" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">22 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%86%D8%AA%D8%B1%D9%88%D8%A8%D8%B1%D9%88%D8%B3%D9%8A%D8%AF_%D8%A7%D9%84%D8%B5%D9%88%D8%AF%D9%8A%D9%88%D9%85" title="نتروبروسيد الصوديوم – arabe" lang="ar" hreflang="ar" data-title="نتروبروسيد الصوديوم" data-language-autonym="العربية" data-language-local-name="arabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%86%DB%8C%D8%AA%D8%B1%D9%88%D9%BE%D8%B1%D9%88%D8%B3%D8%A7%DB%8C%D8%AF_%D8%B3%D8%AF%DB%8C%D9%85" title="نیتروپروساید سدیم – South Azerbaijani" lang="azb" hreflang="azb" data-title="نیتروپروساید سدیم" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-cv mw-list-item"><a href="https://cv.wikipedia.org/wiki/%D0%9D%D0%B0%D1%82%D1%80%D0%B8%D0%B9_%D0%BD%D0%B8%D1%82%D1%80%D0%BE%D0%BF%D1%80%D1%83%D1%81%D1%81%D0%B8%D1%87%C4%95" title="Натрий нитропруссичĕ – tchouvache" lang="cv" hreflang="cv" data-title="Натрий нитропруссичĕ" data-language-autonym="Чӑвашла" data-language-local-name="tchouvache" class="interlanguage-link-target"><span>Чӑвашла</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Nitroprussid" title="Nitroprussid – allemand" lang="de" hreflang="de" data-title="Nitroprussid" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Sodium_nitroprusside" title="Sodium nitroprusside – anglais" lang="en" hreflang="en" data-title="Sodium nitroprusside" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Nitroprusiato" title="Nitroprusiato – espagnol" lang="es" hreflang="es" data-title="Nitroprusiato" data-language-autonym="Español" data-language-local-name="espagnol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%B3%D8%AF%DB%8C%D9%85_%D9%86%DB%8C%D8%AA%D8%B1%D9%88%D9%BE%D8%B1%D9%88%D8%B3%D8%A7%DB%8C%D8%AF" title="سدیم نیتروپروساید – persan" lang="fa" hreflang="fa" data-title="سدیم نیتروپروساید" data-language-autonym="فارسی" data-language-local-name="persan" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Nitroprussidi" title="Nitroprussidi – finnois" lang="fi" hreflang="fi" data-title="Nitroprussidi" data-language-autonym="Suomi" data-language-local-name="finnois" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A0%D7%AA%D7%A8%D7%9F_%D7%A0%D7%99%D7%98%D7%A8%D7%95%D7%A4%D7%A8%D7%95%D7%A1%D7%99%D7%93%D7%99" title="נתרן ניטרופרוסידי – hébreu" lang="he" hreflang="he" data-title="נתרן ניטרופרוסידי" data-language-autonym="עברית" data-language-local-name="hébreu" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Nitroprusid" title="Nitroprusid – croate" lang="hr" hreflang="hr" data-title="Nitroprusid" data-language-autonym="Hrvatski" data-language-local-name="croate" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Natrium_nitroprusida" title="Natrium nitroprusida – indonésien" lang="id" hreflang="id" data-title="Natrium nitroprusida" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonésien" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Nitroprussiato_di_sodio" title="Nitroprussiato di sodio – italien" lang="it" hreflang="it" data-title="Nitroprussiato di sodio" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%8B%E3%83%88%E3%83%AD%E3%83%97%E3%83%AB%E3%82%B7%E3%83%89" title="ニトロプルシド – japonais" lang="ja" hreflang="ja" data-title="ニトロプルシド" data-language-autonym="日本語" data-language-local-name="japonais" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%B8%E0%AD%8B%E0%AC%A1%E0%AC%BC%E0%AC%BF%E0%AC%85%E0%AC%AE_%E0%AC%A8%E0%AC%BE%E0%AC%87%E0%AC%9F%E0%AD%8D%E0%AC%B0%E0%AD%8B%E0%AC%AA%E0%AD%83%E0%AC%B8%E0%AC%BE%E0%AC%87%E0%AC%A1" title="ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡ – odia" lang="or" hreflang="or" data-title="ସୋଡ଼ିଅମ ନାଇଟ୍ରୋପୃସାଇଡ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Nitroprusydek_sodu" title="Nitroprusydek sodu – polonais" lang="pl" hreflang="pl" data-title="Nitroprusydek sodu" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Nitroprussiato_de_s%C3%B3dio" title="Nitroprussiato de sódio – portugais" lang="pt" hreflang="pt" data-title="Nitroprussiato de sódio" data-language-autonym="Português" data-language-local-name="portugais" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Nitroprusiat_de_sodiu" title="Nitroprusiat de sodiu – roumain" lang="ro" hreflang="ro" data-title="Nitroprusiat de sodiu" data-language-autonym="Română" data-language-local-name="roumain" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Natrijum_nitroprusid" title="Natrijum nitroprusid – serbo-croate" lang="sh" hreflang="sh" data-title="Natrijum nitroprusid" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Natrijum_nitroprusid" title="Natrijum nitroprusid – serbe" lang="sr" hreflang="sr" data-title="Natrijum nitroprusid" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9D%D0%B0%D1%82%D1%80%D1%96%D0%B9_%D0%BD%D1%96%D1%82%D1%80%D0%BE%D0%BF%D1%80%D1%83%D1%81%D0%B8%D0%B4" title="Натрій нітропрусид – ukrainien" lang="uk" hreflang="uk" data-title="Натрій нітропрусид" data-language-autonym="Українська" data-language-local-name="ukrainien" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Natri_nitroprusside" title="Natri nitroprusside – vietnamien" lang="vi" hreflang="vi" data-title="Natri nitroprusside" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamien" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%A1%9D%E6%99%AE%E9%92%A0" title="硝普钠 – chinois" lang="zh" hreflang="zh" data-title="硝普钠" data-language-autonym="中文" data-language-local-name="chinois" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q27108300#sitelinks-wikipedia" title="Modifier les liens interlangues" class="wbc-editpage">Modifier les liens</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Espaces de noms"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Nitroprussiate_de_sodium" title="Voir le contenu de la page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Discussion:Nitroprussiate_de_sodium" rel="discussion" title="Discussion au sujet de cette page de contenu [t]" accesskey="t"><span>Discussion</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Modifier la variante de langue" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">français</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Affichages"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Nitroprussiate_de_sodium"><span>Lire</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;veaction=edit" title="Modifier cette page [v]" accesskey="v"><span>Modifier</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;action=edit" title="Modifier le wikicode de cette page [e]" accesskey="e"><span>Modifier le code</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;action=history" title="Historique des versions de cette page [h]" accesskey="h"><span>Voir l’historique</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Outils de la page"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Outils" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Outils</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Outils</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">masquer</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Plus d’options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected 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de cette version de cette page"><span>Lien permanent</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;action=info" title="Davantage d’informations sur cette page"><span>Informations sur la page</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:Citer&amp;page=Nitroprussiate_de_sodium&amp;id=206668406&amp;wpFormIdentifier=titleform" title="Informations sur la manière de citer cette page"><span>Citer cette page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:UrlShortener&amp;url=https%3A%2F%2Ffr.wikipedia.org%2Fwiki%2FNitroprussiate_de_sodium"><span>Obtenir l'URL raccourcie</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:QrCode&amp;url=https%3A%2F%2Ffr.wikipedia.org%2Fwiki%2FNitroprussiate_de_sodium"><span>Télécharger le code QR</span></a></li> </ul> </div> </div> <div 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data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Un article de Wikipédia, l&#039;encyclopédie libre.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><p class="mw-empty-elt"> </p> <table class="infobox_v2 infobox infobox--frwiki noarchive"> <tbody><tr> <td colspan="2" class="entete defaut" style="background-color:#FFDEAD;color:black;">Nitroprussiate de sodium </td></tr> <tr><td colspan="2" style="display:none;"> </td></tr> <tr> <td colspan="2" style="text-align:center;"><span typeof="mw:File"><a href="/wiki/Fichier:Sodium-nitroprusside-sample.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Sodium-nitroprusside-sample.jpg/200px-Sodium-nitroprusside-sample.jpg" decoding="async" width="200" height="150" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Sodium-nitroprusside-sample.jpg/300px-Sodium-nitroprusside-sample.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Sodium-nitroprusside-sample.jpg/400px-Sodium-nitroprusside-sample.jpg 2x" data-file-width="1861" data-file-height="1396" /></a></span><br /><span typeof="mw:File"><a href="/wiki/Fichier:Sodium-nitroprusside-2D.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0c/Sodium-nitroprusside-2D.png/225px-Sodium-nitroprusside-2D.png" decoding="async" width="225" height="158" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0c/Sodium-nitroprusside-2D.png/338px-Sodium-nitroprusside-2D.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0c/Sodium-nitroprusside-2D.png/450px-Sodium-nitroprusside-2D.png 2x" data-file-width="1100" data-file-height="771" /></a></span><br />Apparence et structure du nitroprussiate de sodium</td> </tr><tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Identification</th></tr> <tr> <th scope="row"><a href="/wiki/Nomenclature_de_l%27UICPA" title="Nomenclature de l&#39;UICPA">Nom UICPA</a> </th> <td><small>dihydrate de pentacyanidonitrosylferrate(II) de sodium</small> </td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CAS" title="Numéro CAS">N<sup>o</sup> CAS</a> </th> <td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=13755-38-9&amp;language=fr&amp;title=Nitroprussiate_de_sodium">13755-38-9</a></span></span> (<a href="/wiki/Hydrate" title="Hydrate">dihydrate</a>) </td> </tr> <tr> <th scope="row"> N<sup>o</sup> <a href="/wiki/Agence_europ%C3%A9enne_des_produits_chimiques" title="Agence européenne des produits chimiques">ECHA</a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.119.126">100.119.126</a></span></span></td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CE" title="Numéro CE">N<sup>o</sup> CE</a> </th> <td>238-373-9 (<a href="/wiki/Hydrate" title="Hydrate">dihydrate</a>) </td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_RTECS" title="Numéro RTECS">N<sup>o</sup> RTECS</a> </th> <td>LJ8925000 (<a href="/wiki/Hydrate" title="Hydrate">dihydrate</a>) </td> </tr> <tr> <th scope="row"><a href="/wiki/Classification_ATC" title="Classification ATC">Code ATC</a> </th> <td><a href="/wiki/Classe_ATC_C02" title="Classe ATC C02"><span title="CARDIOVASCULAR SYSTEM, ANTIHYPERTENSIVES, ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON, Nitroferricyanide derivatives, nitroprusside">C02</span></a><span class="reflink plainlinksneverexpand"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=C02DD01">DD01</a></span></span> </td> </tr> <tr> <th scope="row">DrugBank </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DB00325">DB00325</a></span></span> </td> </tr> <tr> <th scope="row"><a href="/wiki/PubChem" title="PubChem">PubChem</a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/11953895">11953895</a></span></span> (<a href="/wiki/Hydrate" title="Hydrate">dihydrate</a>) </td> </tr> <tr> <th scope="row">ChEBI </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.ebi.ac.uk/chebi/searchId.do?chebiId=9179">9179</a></span></span> </td> </tr> <tr> <th scope="row"><a href="/wiki/Simplified_Molecular_Input_Line_Entry_System" title="Simplified Molecular Input Line Entry System">SMILES</a> </th> <td><div class="NavFrame" title="&#91;Afficher&#93;/&#91;Masquer&#93;" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;">[Na+].[Na+].[H]O[H].[H]O[H].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N <br /><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/search/?smarts=%5BNa%2B%5D.%5BNa%2B%5D.%5BH%5DO%5BH%5D.%5BH%5DO%5BH%5D.O%3DN%5BFe--%5D%28C%23N%29%28C%23N%29%28C%23N%29%28C%23N%29C%23N">PubChem</a></span>, <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=Nitroprussiate+de+sodium&amp;model=%5BNa%2B%5D.%5BNa%2B%5D.%5BH%5DO%5BH%5D.%5BH%5DO%5BH%5D.O%3DN%5BFe--%5D%28C%23N%29%28C%23N%29%28C%23N%29%28C%23N%29C%23N">vue 3D</a></span></div></div> </td> </tr> <tr> <th scope="row"><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a> </th> <td><div class="NavFrame" title="&#91;Afficher&#93;/&#91;Masquer&#93;" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;"><b>Std. InChI&#160;:</b> <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=Nitroprussiate+de+sodium&amp;model=InChI%3D1S%2F5CN.Fe.NO.2Na.2H2O%2Fc5%2A1-2%3B%3B1-2%3B%3B%3B%3B%2Fh%3B%3B%3B%3B%3B%3B%3B%3B%3B2%2A1H2%2Fq%3B%3B%3B%3B%3B2%2A-1%3B2%2A%2B1%3B%3B">vue 3D</a></span> <br />InChI&#61;1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q;;;;;2*-1;2*+1;; <br /><b>Std. InChIKey&#160;:</b> <br />OIRZWVYIQXBRFC-UHFFFAOYSA-N</div></div> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Propriétés chimiques</th></tr> <tr> <th scope="row"><a href="/wiki/Formule_chimique" title="Formule chimique">Formule</a> </th> <td><a href="/wiki/Carbone" title="Carbone">C</a><sub>5</sub><a href="/wiki/Fer" title="Fer">Fe</a><a href="/wiki/Azote" title="Azote">N</a><sub>6</sub><a href="/wiki/Sodium" title="Sodium">Na</a><sub>2</sub><a href="/wiki/Oxyg%C3%A8ne" title="Oxygène">O</a><br /> </td> </tr> <tr> <th scope="row"><a href="/wiki/Masse_molaire" title="Masse molaire">Masse molaire</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup> </th> <td>261,918&#160;±&#160;0,008&#160;<a href="/wiki/Gramme" title="Gramme">g</a>/<a href="/wiki/Mole_(unit%C3%A9)" title="Mole (unité)">mol</a> <br /><small>C&#160;22,93&#160;%, &#32;Fe&#160;21,32&#160;%, &#32;N&#160;32,09&#160;%, &#32;Na&#160;17,55&#160;%, &#32;O&#160;6,11&#160;%, &#32;</small> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#ffb4b4; color:#000000">Précautions</th></tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#eeeeee; color:#000000"><a href="/wiki/Syst%C3%A8me_g%C3%A9n%C3%A9ral_harmonis%C3%A9_de_classification_et_d%27%C3%A9tiquetage_des_produits_chimiques" title="Système général harmonisé de classification et d&#39;étiquetage des produits chimiques">SGH</a><sup id="cite_ref-sa_2-0" class="reference"><a href="#cite_note-sa-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup></th></tr> <tr> <td colspan="2" style="text-align:center;"><div style="text-align: center;"><span typeof="mw:File"><a href="/wiki/Fichier:GHS-pictogram-skull.svg" class="mw-file-description" title="SGH06 : Toxique"><img alt="SGH06 : Toxique" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/58/GHS-pictogram-skull.svg/60px-GHS-pictogram-skull.svg.png" decoding="async" width="60" height="60" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/58/GHS-pictogram-skull.svg/90px-GHS-pictogram-skull.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/58/GHS-pictogram-skull.svg/120px-GHS-pictogram-skull.svg.png 2x" data-file-width="724" data-file-height="724" /></a></span><br />Danger</div><span title="Toxique en cas d&#39;ingestion">H301</span> et <span title="En cas d&#39;ingestion : appeler immédiatement un CENTRE ANTIPOISON ou un médecin.">P301+P310</span><div class="NavFrame" title="&#91;+&#93;/&#91;–&#93;" style="border:none; padding : 0;"><div class="NavContent" style="display:none; text-align:left;"><b>H301</b>&#160;: Toxique en cas d'ingestion<br /><b>P301+P310</b>&#160;: En cas d'ingestion&#160;: appeler immédiatement un CENTRE ANTIPOISON ou un médecin.<br /></div></div></td> </tr><tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#eeeeee; color:#000000"><a href="/wiki/Accord_relatif_au_transport_international_des_marchandises_dangereuses_par_route" title="Accord relatif au transport international des marchandises dangereuses par route">Transport</a><sup id="cite_ref-sa_2-1" class="reference"><a href="#cite_note-sa-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup></th></tr> <tr> <td colspan="2" style="text-align:center;"><div class="center"><table class="wikitable centre" style="width:33px margin:0px; background-color:#ff950e; border: 1px solid black;"><tbody><tr><td width="100%" style="background-color:#ff950e; border: 1px solid black;"><div style="text-align:center">-</div></td></tr><tr><td width="100%" style="background-color:#ff950e; border: 1px solid black;"><div style="text-align:center">&#160;&#160;&#160;<a href="/wiki/Liste_des_num%C3%A9ros_ONU" title="Liste des numéros ONU"><span style="color: black;" title="numéro ONU">3288</span></a>&#160;&#160;&#160;</div></td></tr></tbody></table><div class="NavFrame" title="&#91;+&#93;/&#91;–&#93;" style="border:none; padding: 0;"><div class="NavContent" style="display:none; text-align:left;"><b><a href="/wiki/Num%C3%A9ro_ONU" title="Numéro ONU">Numéro ONU</a>&#160;:</b><br /><b><a href="/wiki/Liste_des_num%C3%A9ros_ONU" title="Liste des numéros ONU">3288</a></b>&#160;: SOLIDE INORGANIQUE TOXIQUE, N.S.A.<br /><b>Classe&#160;:</b><br />6.1<br /><b>Étiquette&#160;:</b><br /><span typeof="mw:File"><a href="/wiki/Fichier:Dangclass6_1.svg" class="mw-file-description"><img alt="pictogramme ADR 6.1" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Dangclass6_1.svg/75px-Dangclass6_1.svg.png" decoding="async" width="75" height="75" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/Dangclass6_1.svg/113px-Dangclass6_1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/72/Dangclass6_1.svg/150px-Dangclass6_1.svg.png 2x" data-file-width="430" data-file-height="430" /></a></span><br /><b>6.1</b>&#160;: Matières toxiques<br /><b>Emballage&#160;:</b><br />Groupe d'emballage <abbr class="abbr" title="3"><span class="romain" style="text-transform:uppercase">III</span></abbr>&#160;: matières faiblement dangereuses.<br /></div></div></div></td> </tr><tr> <td colspan="2"><hr style="height:2px; background-color:#FFDEAD;" /></td></tr> <tr> <td colspan="2" style="text-align:center;">Unités du <a href="/wiki/Syst%C3%A8me_international_d%27unit%C3%A9s" title="Système international d&#39;unités">SI</a> et <a href="/wiki/Conditions_normales_de_temp%C3%A9rature_et_de_pression" title="Conditions normales de température et de pression"><abbr title="conditions normales de température et de pression">CNTP</abbr></a>, sauf indication contraire.</td> </tr><tr> <td class="navigation-only" colspan="2" style="border-top: 2px #FFDEAD solid; font-size: 80%; background:inherit; text-align: right;"><span class="plainlinks" style="float:left;"><a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Nitroprussiate_de_sodium&amp;action=edit&amp;section=0"><span class="infodoc">modifier</span></a></span>&#160;<span typeof="mw:File"><a href="/wiki/Mod%C3%A8le:Infobox_Chimie" title="Consultez la documentation du modèle"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></td> </tr> </tbody></table> <p>Le <b>nitroprussiate de sodium</b> est un <a href="/wiki/Compos%C3%A9_chimique" title="Composé chimique">composé chimique</a> de <a href="/wiki/Formule_chimique" title="Formule chimique">formule</a> Na<sub>2</sub>[Fe(CN)<sub>5</sub>NO]<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> rencontré le plus souvent sous forme de <a href="/wiki/Hydrate" title="Hydrate">dihydrate</a> Na<sub>2</sub>[Fe(CN)<sub>5</sub>NO]·2H<sub>2</sub>O<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sup id="cite_ref-10.1021/cr000076d_3-0" class="reference"><a href="#cite_note-10.1021/cr000076d-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup>. Il se présente sous la forme d'un solide rouge cristallisé très soluble dans l'eau et l'<a href="/wiki/%C3%89thanol" title="Éthanol">éthanol</a> pour donner des solutions contenant le <a href="/wiki/Anion" title="Anion">dianion</a> [Fe(CN)<sub>5</sub>NO]<sup>2−</sup><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> libre. Abrégé <b>SNP</b> (pour l'anglais <span class="lang-en" lang="en"><i>sodium nitroprusside</i></span>), il est utilisé comme <a href="/wiki/Vasodilatateur" title="Vasodilatateur">vasodilatateur</a> de la famille des <a href="/wiki/D%C3%A9riv%C3%A9_nitr%C3%A9" title="Dérivé nitré">dérivés nitrés</a>, qui agissent comme <a href="/wiki/Antihypertenseur" title="Antihypertenseur">antihypertenseurs</a> par libération de <a href="/wiki/Monoxyde_d%27azote" title="Monoxyde d&#39;azote">monoxyde d'azote</a> NO. </p> <div class="mw-heading mw-heading2"><h2 id="Préparation_et_propriétés"><span id="Pr.C3.A9paration_et_propri.C3.A9t.C3.A9s"></span>Préparation et propriétés</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;veaction=edit&amp;section=1" title="Modifier la section : Préparation et propriétés" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;action=edit&amp;section=1" title="Modifier le code source de la section : Préparation et propriétés"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il peut être préparé en traitant une <a href="/wiki/Solution_aqueuse" title="Solution aqueuse">solution aqueuse</a> de <a href="/wiki/Ferrocyanure_de_potassium" title="Ferrocyanure de potassium">ferrocyanure de potassium</a> K<sub>4</sub>[Fe(CN)<sub>6</sub>]<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> avec de l'<a href="/wiki/Acide_nitrique" title="Acide nitrique">acide nitrique</a> HNO<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> puis neutralisation au <a href="/wiki/Carbonate_de_sodium" title="Carbonate de sodium">carbonate de sodium</a> Na<sub>2</sub>CO<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub>&#160;: </p> <dl><dd><a href="/wiki/Ferrocyanure_de_potassium" title="Ferrocyanure de potassium">K<sub>4</sub>[Fe(CN)<sub>6</sub>]<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> + 6<a href="/wiki/Acide_nitrique" title="Acide nitrique">HNO<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> → H<sub>2</sub>[Fe(CN)<sub>5</sub>(NO)]<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> + <a href="/wiki/Dioxyde_de_carbone" title="Dioxyde de carbone">CO<sub>2</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> + <a href="/wiki/Nitrate_d%27ammonium" title="Nitrate d&#39;ammonium">NH<sub>4</sub>NO<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> + 4<a href="/wiki/Nitrate_de_potassium" title="Nitrate de potassium">KNO<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a>&#160;;</dd> <dd>H<sub>2</sub>[Fe(CN)<sub>5</sub>NO]<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> + <a href="/wiki/Carbonate_de_sodium" title="Carbonate de sodium">Na<sub>2</sub>CO<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> → Na<sub>2</sub>[Fe(CN)<sub>5</sub>(NO)]<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> + <a href="/wiki/Dioxyde_de_carbone" title="Dioxyde de carbone">CO<sub>2</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> + <a href="/wiki/Eau" title="Eau">H<sub>2</sub>O<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a>.</dd></dl> <p>Le <a href="/wiki/Ferrocyanure" title="Ferrocyanure">ferrocyanure</a> peut également être <a href="/wiki/Oxydation" class="mw-redirect" title="Oxydation">oxydé</a> par des <a href="/wiki/Ion" title="Ion">ions</a> <a href="/wiki/Nitrite" title="Nitrite">nitrite</a>&#160;: </p> <dl><dd><a href="/wiki/Ferrocyanure" title="Ferrocyanure">[Fe(CN)<sub>6</sub>]<sup>4−</sup><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> + <a href="/wiki/Eau" title="Eau">H<sub>2</sub>O<sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> + <a href="/wiki/Nitrite" title="Nitrite">NO<sub>2</sub><sup>−</sup><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub></a> → [Fe(CN)<sub>5</sub>(NO)]<sup>2−</sup><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> + <a href="/wiki/Cyanure" title="Cyanure">CN<sup>−</sup></a> + 2<a href="/wiki/Hydroxyde" title="Hydroxyde">OH<sup>−</sup></a>.</dd></dl> <p>L'<a href="/wiki/Anion" title="Anion">anion</a> nitroprussiate [Fe(CN)<sub>5</sub>(NO)]<sup>2−</sup><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> est un <a href="/wiki/Complexe_(chimie)" title="Complexe (chimie)">complexe</a> présentant un centre <a href="/wiki/Fer" title="Fer">ferreux</a> Fe<sup>2+</sup> coordonné avec cinq <a href="/wiki/Ligand_(chimie)" title="Ligand (chimie)">ligands</a> <a href="/wiki/Cyanure" title="Cyanure">cyanure</a> CN<sup>−</sup> et un ligand de <a href="/wiki/Monoxyde_d%27azote" title="Monoxyde d&#39;azote">monoxyde d'azote</a> NO<sup>+</sup> formant un angle Fe-N-O de 176,2°. Il possède une <a href="/wiki/Groupe_ponctuel_de_sym%C3%A9trie" title="Groupe ponctuel de symétrie">symétrie</a> C<sub>4v</sub>. </p><p>Les réactions du nitroprussiate de sodium sont essentiellement dues au ligand NO. Ainsi, l'addition d'ions <a href="/wiki/Sulfure" title="Sulfure">sulfure</a> S<sup>2−</sup> conduit à l'ion rouge [Fe(CN)<sub>5</sub>(NOS)]<sup>4−</sup><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub>, qui est à la base de la détection des ions sulfure par le nitroprussiate. Il existe une réaction analogue avec les ions <a href="/wiki/Hydroxyde" title="Hydroxyde">hydroxyde</a> OH<sup>−</sup>, qui donnent l'ion [Fe(CN)<sub>5</sub>(NO2)]<sup>4−</sup><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub>. </p><p>Le <a href="/w/index.php?title=Sel_rouge_de_Roussin&amp;action=edit&amp;redlink=1" class="new" title="Sel rouge de Roussin (page inexistante)">sel rouge de Roussin</a>&#160;<a href="https://en.wikipedia.org/wiki/Roussin%27s_red_salt" class="extiw" title="en:Roussin&#39;s red salt"><span class="indicateur-langue" title="Article en anglais&#160;: «&#160;Roussin&#39;s red salt&#160;»">(en)</span></a> K<sub>2</sub>[Fe<sub>2</sub>S<sub>2</sub>(NO)<sub>4]</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> et le <a href="/w/index.php?title=Sel_noir_de_Roussin&amp;action=edit&amp;redlink=1" class="new" title="Sel noir de Roussin (page inexistante)">sel noir de Roussin</a>&#160;<a href="https://en.wikipedia.org/wiki/Roussin%27s_black_salt" class="extiw" title="en:Roussin&#39;s black salt"><span class="indicateur-langue" title="Article en anglais&#160;: «&#160;Roussin&#39;s black salt&#160;»">(en)</span></a> NaFe<sub>4</sub>S<sub>3</sub>(NO)<sub>7</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub> sont des complexes <a href="/wiki/Nitroso" title="Nitroso">nitroso</a> apparentés. Le premier a été obtenu à l'origine en traitant du nitroprussiate avec du soufre. </p> <div class="mw-heading mw-heading2"><h2 id="Application_en_pharmacie">Application en pharmacie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;veaction=edit&amp;section=2" title="Modifier la section : Application en pharmacie" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;action=edit&amp;section=2" title="Modifier le code source de la section : Application en pharmacie"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Le nitroprussiate se lie rapidement à l'<a href="/wiki/Oxyh%C3%A9moglobine" class="mw-redirect" title="Oxyhémoglobine">oxyhémoglobine</a> dans le <a href="/wiki/Sang" title="Sang">sang</a> pour former de la <a href="/wiki/M%C3%A9th%C3%A9moglobine" title="Méthémoglobine">méthémoglobine</a> avec libération concomitante de <a href="/wiki/Cyanure" title="Cyanure">cyanure</a> CN<sup>−</sup> et de <a href="/wiki/Monoxyde_de_carbone" title="Monoxyde de carbone">monoxyde d</a>'azote NO<sup id="cite_ref-&#80;MID_7598246_4-0" class="reference"><a href="#cite_note-PMID_7598246-4"><span class="cite_crochet">[</span>4<span class="cite_crochet">]</span></a></sup>. Le nitroprussiate est donc un <a href="/wiki/Prom%C3%A9dicament" class="mw-redirect" title="Promédicament">promédicament</a>. Pour ne pas compromettre le bénéfice thérapeutique du monoxyde d'azote, la <a href="/wiki/Intoxication_au_cyanure" title="Intoxication au cyanure">toxicité du cyanure</a> libéré par cette réaction doit être compensée par une <a href="/wiki/D%C3%A9toxication" title="Détoxication">détoxication</a> au <a href="/wiki/Thiosulfate_de_sodium" title="Thiosulfate de sodium">thiosulfate de sodium</a> Na<sub>2</sub>S<sub>2</sub>O<sub>3</sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub><sub></sub>, converti par la <a href="/wiki/Rhodan%C3%A8se" title="Rhodanèse">rhodanèse</a> en <a href="/wiki/Thiocyanate" title="Thiocyanate">thiocyanate</a> SCN<sup>−</sup> excrété par <a href="/wiki/Voie_r%C3%A9nale" class="mw-redirect" title="Voie rénale">voie rénale</a>. </p><p>Le monoxyde d'azote active la <a href="/wiki/Guanylate_cyclase" title="Guanylate cyclase">guanylate cyclase</a> du <a href="/wiki/Muscle_lisse" title="Muscle lisse">muscle lisse</a> <a href="/wiki/Vasculaire_(anatomie)" class="mw-redirect" title="Vasculaire (anatomie)">vasculaire</a>, ce qui a pour effet d'accroître le taux intracellulaire de <a href="/wiki/Guanosine_monophosphate_cyclique" title="Guanosine monophosphate cyclique">GMP cyclique</a>. Ce dernier active une <a href="/wiki/Prot%C3%A9ine_kinase_G" title="Protéine kinase G">protéine kinase G</a>, d'où l'activation de <a href="/wiki/Phosphatase" title="Phosphatase">phosphatases</a> qui inactivent les chaînes légères de <a href="/wiki/Myosine" title="Myosine">myosine</a><sup id="cite_ref-10.1172/JCI112536_5-0" class="reference"><a href="#cite_note-10.1172/JCI112536-5"><span class="cite_crochet">[</span>5<span class="cite_crochet">]</span></a></sup>. Ces dernières sont essentielles à la <a href="/wiki/Contraction_musculaire" title="Contraction musculaire">contraction musculaire</a>, leur inactivation ayant un effet <a href="/wiki/Myorelaxant" title="Myorelaxant">myorelaxant</a> qui conduit à la dilatation du système vasculaire. </p><p>Le nitroprussiate de sodium présente un puissant effet <a href="/wiki/Vasodilatateur" title="Vasodilatateur">vasodilatateur</a> dans les <a href="/wiki/Art%C3%A9riole" title="Artériole">artérioles</a> et les <a href="/wiki/Veinule" title="Veinule">veinules</a>, surtout dans les premières, bien que cette sélectivité soit moins marquée que pour la <a href="/wiki/Nitroglyc%C3%A9rine" title="Nitroglycérine">nitroglycérine</a>. Il est administré par <a href="/wiki/Injection_intraveineuse" title="Injection intraveineuse">injection intraveineuse</a> dans le cas d'<a href="/wiki/Hypertension_art%C3%A9rielle" title="Hypertension artérielle">hypertension artérielle</a> sévère. Son effet est visible en quelques minutes mais sa <a href="/wiki/Demi-vie" title="Demi-vie">demi-vie</a> d'à peine une dizaine de minutes implique une injection prolongée sous surveillance médicale étroite. </p><p>Il fait partie de la liste des médicaments essentiels de l'<a href="/wiki/Organisation_mondiale_de_la_sant%C3%A9" title="Organisation mondiale de la santé">Organisation mondiale de la santé</a> (liste mise à jour en <time class="nowrap" datetime="2013-04" data-sort-value="2013-04">avril 2013</time>)<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite_crochet">[</span>6<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;veaction=edit&amp;section=3" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Nitroprussiate_de_sodium&amp;action=edit&amp;section=3" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references-small decimal" style=""><div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink noprint"><a href="#cite_ref-1">↑</a> </span><span class="reference-text">Masse molaire calculée d’après <span class="ouvrage">«&#160;<a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/AtWt/"><cite style="font-style:normal;"><span class="lang-en" lang="en">Atomic weights of the elements 2007</span></cite></a>&#160;», sur <span class="italique">www.chem.qmul.ac.uk</span></span>.</span> </li> <li id="cite_note-sa-2"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-sa_2-0">a</a> <a href="#cite_ref-sa_2-1">b</a> et <a href="#cite_ref-sa_2-2">c</a></sup> </span><span class="reference-text">Fiche <a href="/wiki/Sigma-Aldrich" title="Sigma-Aldrich">Sigma-Aldrich</a> du composé <i><a rel="nofollow" class="external text" href="https://www.sigmaaldrich.com/FR/fr/product/SIAL/71778?context=bbe">Sodium nitroprusside dihydrate puriss. p.a., ACS reagent, reag. Ph. Eur., Reag. Ph. Eur., ≥99%</a></i>, consultée le 1 juin 2014.</span> </li> <li id="cite_note-10.1021/cr000076d-3"><span class="mw-cite-backlink noprint"><a href="#cite_ref-10.1021/cr000076d_3-0">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="Anthony_R._Butler_et_Ian_L._Megson2002"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <span class="nom_auteur">Anthony R. Butler et Ian L. Megson</span>, «&#160;<cite style="font-style:normal" lang="en">Non-Heme Iron Nitrosyls in Biology</cite>&#160;», <i><span class="lang-en" lang="en">Chemical Reviews</span></i>, <abbr class="abbr" title="volume">vol.</abbr>&#160;102, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr>&#160;4,&#8206; <time class="nowrap" datetime="2002-04" data-sort-value="2002-04">avril 2002</time>, <abbr class="abbr" title="pages">p.</abbr>&#160;<span class="nowrap">1155-1166</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a>&#160;<span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/11942790">11942790</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>&#160;<span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1021/cr000076d">10.1021/cr000076d</a></span>, <a rel="nofollow" class="external text" href="http://pubs.acs.org/doi/abs/10.1021/cr000076d?journalCode=chreay">lire en ligne</a>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.atitle=Non-Heme+Iron+Nitrosyls+in+Biology&amp;rft.jtitle=Chemical+Reviews&amp;rft.issue=4&amp;rft.aulast=Anthony+R.+Butler+et+Ian+L.+Megson&amp;rft.date=2002-04&amp;rft.volume=102&amp;rft.pages=1155-1166&amp;rft_id=info%3Adoi%2F10.1021%2Fcr000076d&amp;rft_id=info%3Apmid%2F11942790&amp;rfr_id=info%3Asid%2Ffr.wikipedia.org%3ANitroprussiate+de+sodium"></span></span></span> </li> <li id="cite_note-&#80;MID_7598246-4"><span class="mw-cite-backlink noprint"><a href="#cite_ref-PMID_7598246_4-0">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="Jeffrey_A._Friederich_et_John_F._Butterworth1995"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <span class="nom_auteur">Jeffrey A. Friederich et John F. Butterworth</span>, «&#160;<cite style="font-style:normal" lang="en">Sodium Nitroprusside: Twenty Years and Counting</cite>&#160;», <i><span class="lang-en" lang="en">Anesthesia &amp; Analgesia</span></i>, <abbr class="abbr" title="volume">vol.</abbr>&#160;81, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr>&#160;1,&#8206; <time class="nowrap" datetime="1995-07" data-sort-value="1995-07">juillet 1995</time>, <abbr class="abbr" title="pages">p.</abbr>&#160;<span class="nowrap">152-162</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a>&#160;<span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/7598246">7598246</a></span>, <a rel="nofollow" class="external text" href="http://journals.lww.com/anesthesia-analgesia/Fulltext/1995/07000/Sodium_Nitroprusside__Twenty_Years_and_Counting.31.aspx">lire en ligne</a>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.atitle=Sodium+Nitroprusside%3A+Twenty+Years+and+Counting&amp;rft.jtitle=Anesthesia+%26+Analgesia&amp;rft.issue=1&amp;rft.aulast=Jeffrey+A.+Friederich+et+John+F.+Butterworth&amp;rft.date=1995-07&amp;rft.volume=81&amp;rft.pages=152-162&amp;rft_id=info%3Apmid%2F7598246&amp;rfr_id=info%3Asid%2Ffr.wikipedia.org%3ANitroprussiate+de+sodium"></span></span></span> </li> <li id="cite_note-10.1172/JCI112536-5"><span class="mw-cite-backlink noprint"><a href="#cite_ref-10.1172/JCI112536_5-0">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="F._Murad1986"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <span class="nom_auteur">F. Murad</span>, «&#160;<cite style="font-style:normal" lang="en">Cyclic guanosine monophosphate as a mediator of vasodilation</cite>&#160;», <i><span class="lang-en" lang="en">Journal of Clinical Investigation</span></i>, <abbr class="abbr" title="volume">vol.</abbr>&#160;78, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr>&#160;1,&#8206; <time class="nowrap" datetime="1986-07" data-sort-value="1986-07">juillet 1986</time>, <abbr class="abbr" title="pages">p.</abbr>&#160;<span class="nowrap">1-5</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a>&#160;<span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/2873150">2873150</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a>&#160;<span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/329522">329522</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a>&#160;<span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1172/JCI112536">10.1172/JCI112536</a></span>, <a rel="nofollow" class="external text" href="http://www.jci.org/articles/view/112536">lire en ligne</a>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&amp;rft.genre=article&amp;rft.atitle=Cyclic+guanosine+monophosphate+as+a+mediator+of+vasodilation&amp;rft.jtitle=Journal+of+Clinical+Investigation&amp;rft.issue=1&amp;rft.aulast=F.+Murad&amp;rft.date=1986-07&amp;rft.volume=78&amp;rft.pages=1-5&amp;rft_id=info%3Adoi%2F10.1172%2FJCI112536&amp;rft_id=info%3Apmid%2F2873150&amp;rfr_id=info%3Asid%2Ffr.wikipedia.org%3ANitroprussiate+de+sodium"></span></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink noprint"><a href="#cite_ref-6">↑</a> </span><span class="reference-text"><a rel="nofollow" class="external text" href="http://apps.who.int/iris/bitstream/10665/93142/1/EML_18_eng.pdf?ua=1">WHO&#160;Model&#160;List&#160;of&#160;Essential&#160;Medicines, <abbr class="abbr" title="Eighteenth" lang="en">18th</abbr>&#160;list</a>, avril 2013</span> </li> </ol></div> </div> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a href="/wiki/Portail:Chimie" title="Portail de la chimie"><img alt="icône décorative" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Nuvola_apps_edu_science.svg/24px-Nuvola_apps_edu_science.svg.png" decoding="async" width="24" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Nuvola_apps_edu_science.svg/36px-Nuvola_apps_edu_science.svg.png 1.5x, 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