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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Cerebellum</h1><div class="u-tcGrayDark">4,813 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Cerebellum</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Cerebellum">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Cerebellum/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Cerebellum/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Cerebellum/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Cerebellum">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73633780" data-work_id="73633780" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73633780/Cerebellar_afferent_projections_from_the_perihypoglossal_nuclei_An_experimental_study_with_the_method_of_retrograde_axonal_transport_of_horseradish_peroxidase">Cerebellar afferent projections from the perihypoglossal nuclei: An experimental study with the method of retrograde axonal transport of horseradish peroxidase</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Details of cerebellar afferent projections from the perihypoglossal nuclei were studied in the cat by means of retrograde axonal transport of horseradish peroxidase (HRP). Labeled cells were observed bilaterally (with a preponderance... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73633780" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Details of cerebellar afferent projections from the perihypoglossal nuclei were studied in the cat by means of retrograde axonal transport of horseradish peroxidase (HRP). Labeled cells were observed bilaterally (with a preponderance ipsilaterally) in nuclei intercalatus and praepositus hypoglossi following injections in various folia of the entire vermis, paraflocculus, flocculus, fastigial nucleus, and the nucleus interpositus anterior and posterior. Relatively high densities of labeled cells were found in nucleus intercalatus following injections in the anterior part of the vermis, whereas labeled cells in nucleus praepositus hypoglossi were found more frequently following injections in the posterior part of the vermis. Labeled cells in the nucleus of Roller were found only following injections in the anterior lobe vermis, posterior vermal lobules VI and VII, in the flocculus and in the nucleus interpositus anterior. No labeled cells could be detected in the three subdivisions of the perihypoglossal nuclei following HRP injections in crus I, crus II, paramedian lobule, and lateral cerebellar nucleus. The distribution of the HRP positive cells indicated the presence of a topographically organized projection from certain regions of the perihypoglossal nuclei to different parts of the cerebellum. The afferent and efferent connections of the perihypoglossal nuclei in relation to a functional role in eye and head movements are discussed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73633780" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5e0da07caed6f17bfcf81df617ae8682" rel="nofollow" data-download="{"attachment_id":83843641,"asset_id":73633780,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83843641/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6127817" href="https://independent.academia.edu/NaiphinichKotchabhakdi">Naiphinich Kotchabhakdi</a><script data-card-contents-for-user="6127817" type="text/json">{"id":6127817,"first_name":"Naiphinich","last_name":"Kotchabhakdi","domain_name":"independent","page_name":"NaiphinichKotchabhakdi","display_name":"Naiphinich Kotchabhakdi","profile_url":"https://independent.academia.edu/NaiphinichKotchabhakdi?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73633780 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73633780"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73633780, container: ".js-paper-rank-work_73633780", }); });</script></li><li class="js-percentile-work_73633780 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73633780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73633780"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73633780 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73633780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73633780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73633780]").text(description); $(".js-view-count-work_73633780").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73633780").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73633780"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="523" rel="nofollow" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41088" rel="nofollow" href="https://www.academia.edu/Documents/in/Cats">Cats</a>, <script data-card-contents-for-ri="41088" type="text/json">{"id":41088,"name":"Cats","url":"https://www.academia.edu/Documents/in/Cats?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73633780]'), work: {"id":73633780,"title":"Cerebellar afferent projections from the perihypoglossal nuclei: An experimental study with the method of retrograde axonal transport of horseradish peroxidase","created_at":"2022-03-12T20:32:23.159-08:00","url":"https://www.academia.edu/73633780/Cerebellar_afferent_projections_from_the_perihypoglossal_nuclei_An_experimental_study_with_the_method_of_retrograde_axonal_transport_of_horseradish_peroxidase?f_ri=65615","dom_id":"work_73633780","summary":"Details of cerebellar afferent projections from the perihypoglossal nuclei were studied in the cat by means of retrograde axonal transport of horseradish peroxidase (HRP). Labeled cells were observed bilaterally (with a preponderance ipsilaterally) in nuclei intercalatus and praepositus hypoglossi following injections in various folia of the entire vermis, paraflocculus, flocculus, fastigial nucleus, and the nucleus interpositus anterior and posterior. Relatively high densities of labeled cells were found in nucleus intercalatus following injections in the anterior part of the vermis, whereas labeled cells in nucleus praepositus hypoglossi were found more frequently following injections in the posterior part of the vermis. Labeled cells in the nucleus of Roller were found only following injections in the anterior lobe vermis, posterior vermal lobules VI and VII, in the flocculus and in the nucleus interpositus anterior. No labeled cells could be detected in the three subdivisions of the perihypoglossal nuclei following HRP injections in crus I, crus II, paramedian lobule, and lateral cerebellar nucleus. The distribution of the HRP positive cells indicated the presence of a topographically organized projection from certain regions of the perihypoglossal nuclei to different parts of the cerebellum. The afferent and efferent connections of the perihypoglossal nuclei in relation to a functional role in eye and head movements are discussed.","downloadable_attachments":[{"id":83843641,"asset_id":73633780,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6127817,"first_name":"Naiphinich","last_name":"Kotchabhakdi","domain_name":"independent","page_name":"NaiphinichKotchabhakdi","display_name":"Naiphinich Kotchabhakdi","profile_url":"https://independent.academia.edu/NaiphinichKotchabhakdi?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=65615","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615","nofollow":true},{"id":41088,"name":"Cats","url":"https://www.academia.edu/Documents/in/Cats?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":215075,"name":"Experimental Study","url":"https://www.academia.edu/Documents/in/Experimental_Study?f_ri=65615"},{"id":2426000,"name":"Brain stem","url":"https://www.academia.edu/Documents/in/Brain_stem?f_ri=65615"},{"id":2777058,"name":"Axonal transport","url":"https://www.academia.edu/Documents/in/Axonal_transport?f_ri=65615"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences?f_ri=65615"},{"id":3443535,"name":"High density","url":"https://www.academia.edu/Documents/in/High_density?f_ri=65615"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_80110816" data-work_id="80110816" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/80110816/AGTR2_Mutations_in_X_Linked_Mental_Retardation">AGTR2 Mutations in X-Linked Mental Retardation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Two angiotensin II (Ang II)–specific receptors, AGTR1 and AGTR2, are expressed in the mammalian brain. Ang II actions on blood pressure regulation, water electrolyte balance, and hormone secretion are primarily mediated by AGTR1. The... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_80110816" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Two angiotensin II (Ang II)–specific receptors, AGTR1 and AGTR2, are expressed in the mammalian brain. Ang II actions on blood pressure regulation, water electrolyte balance, and hormone secretion are primarily mediated by AGTR1. The function of AGTR2 remains unclear. Here, we show that expression of the AGTR2 gene was absent in a female patient with mental retardation (MR) who had a balanced X;7 chromosomal translocation. Additionally, 8 of 590 unrelated male patients with MR were found to have sequence changes in the AGTR2 gene, including one frameshift and three missense mutations. These findings indicate a role for AGTR2 in brain development and cognitive function.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/80110816" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="388836362556aef9b71244bf859e5225" rel="nofollow" data-download="{"attachment_id":86601990,"asset_id":80110816,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86601990/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="189453240" href="https://independent.academia.edu/PennyEdwards6">Penny Edwards</a><script data-card-contents-for-user="189453240" type="text/json">{"id":189453240,"first_name":"Penny","last_name":"Edwards","domain_name":"independent","page_name":"PennyEdwards6","display_name":"Penny Edwards","profile_url":"https://independent.academia.edu/PennyEdwards6?f_ri=65615","photo":"https://0.academia-photos.com/189453240/52709546/40824537/s65_penny.edwards.jpeg"}</script></span></span></li><li class="js-paper-rank-work_80110816 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="80110816"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 80110816, container: ".js-paper-rank-work_80110816", }); });</script></li><li class="js-percentile-work_80110816 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80110816; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_80110816"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_80110816 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="80110816"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80110816; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80110816]").text(description); $(".js-view-count-work_80110816").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_80110816").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="80110816"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7710" rel="nofollow" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23868" rel="nofollow" href="https://www.academia.edu/Documents/in/Intellectual_Disability">Intellectual Disability</a>, <script data-card-contents-for-ri="23868" type="text/json">{"id":23868,"name":"Intellectual Disability","url":"https://www.academia.edu/Documents/in/Intellectual_Disability?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28235" rel="nofollow" href="https://www.academia.edu/Documents/in/Multidisciplinary">Multidisciplinary</a><script data-card-contents-for-ri="28235" type="text/json">{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=80110816]'), work: {"id":80110816,"title":"AGTR2 Mutations in X-Linked Mental Retardation","created_at":"2022-05-28T05:29:44.808-07:00","url":"https://www.academia.edu/80110816/AGTR2_Mutations_in_X_Linked_Mental_Retardation?f_ri=65615","dom_id":"work_80110816","summary":"Two angiotensin II (Ang II)–specific receptors, AGTR1 and AGTR2, are expressed in the mammalian brain. Ang II actions on blood pressure regulation, water electrolyte balance, and hormone secretion are primarily mediated by AGTR1. The function of AGTR2 remains unclear. Here, we show that expression of the AGTR2 gene was absent in a female patient with mental retardation (MR) who had a balanced X;7 chromosomal translocation. Additionally, 8 of 590 unrelated male patients with MR were found to have sequence changes in the AGTR2 gene, including one frameshift and three missense mutations. These findings indicate a role for AGTR2 in brain development and cognitive function.","downloadable_attachments":[{"id":86601990,"asset_id":80110816,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":189453240,"first_name":"Penny","last_name":"Edwards","domain_name":"independent","page_name":"PennyEdwards6","display_name":"Penny Edwards","profile_url":"https://independent.academia.edu/PennyEdwards6?f_ri=65615","photo":"https://0.academia-photos.com/189453240/52709546/40824537/s65_penny.edwards.jpeg"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=65615","nofollow":true},{"id":23868,"name":"Intellectual Disability","url":"https://www.academia.edu/Documents/in/Intellectual_Disability?f_ri=65615","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615","nofollow":true},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=65615","nofollow":true},{"id":29538,"name":"Brain development","url":"https://www.academia.edu/Documents/in/Brain_development?f_ri=65615"},{"id":32923,"name":"Gene Silencing","url":"https://www.academia.edu/Documents/in/Gene_Silencing?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=65615"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=65615"},{"id":237185,"name":"Physical chromosome mapping","url":"https://www.academia.edu/Documents/in/Physical_chromosome_mapping?f_ri=65615"},{"id":441653,"name":"Cognitive Function","url":"https://www.academia.edu/Documents/in/Cognitive_Function?f_ri=65615"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=65615"},{"id":954841,"name":"Angiotensin II","url":"https://www.academia.edu/Documents/in/Angiotensin_II?f_ri=65615"},{"id":994106,"name":"Ascomycota","url":"https://www.academia.edu/Documents/in/Ascomycota?f_ri=65615"},{"id":1905343,"name":"Plant Leaves","url":"https://www.academia.edu/Documents/in/Plant_Leaves?f_ri=65615"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=65615"},{"id":3458391,"name":"frameshift mutation","url":"https://www.academia.edu/Documents/in/frameshift_mutation?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_79513174" data-work_id="79513174" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/79513174/A_JOURNAL_OF_NEUROLOGY_The_cerebellar_cognitive_profile">A JOURNAL OF NEUROLOGY The cerebellar cognitive profile</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The cerebellar role in non-motor functions is supported by the clinical finding that lesions confined to cerebellum produce the cerebellar cognitive affective syndrome. Nevertheless, there is no consensus regarding the overall cerebellar... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_79513174" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The cerebellar role in non-motor functions is supported by the clinical finding that lesions confined to cerebellum produce the cerebellar cognitive affective syndrome. Nevertheless, there is no consensus regarding the overall cerebellar contribution to cognition. Among other reasons, this deficiency might be attributed to the small sample sizes and narrow breadths of existing studies on lesions in cerebellar patients, which have focused primarily on a single cognitive domain. The aim of this study was to examine the expression of cerebellar cognitive affective syndrome with regard to lesion topography in a large group of subjects with cerebellar damage. We retrospectively analysed charts from patients in the Ataxia Lab of Santa Lucia Foundation between 1997 and 2007. Of 223 charts, 156 were included in the study, focusing on the importance of the cerebellum in cognition and the relevance of lesion topography in defining the cognitive domains that have been affected. Vascular topog-...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/79513174" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9cacd0e0db5b398b1f27827448627bf0" rel="nofollow" data-download="{"attachment_id":86202724,"asset_id":79513174,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86202724/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32689410" href="https://uniroma1.academia.edu/MariaLeggio">Maria Leggio</a><script data-card-contents-for-user="32689410" type="text/json">{"id":32689410,"first_name":"Maria","last_name":"Leggio","domain_name":"uniroma1","page_name":"MariaLeggio","display_name":"Maria Leggio","profile_url":"https://uniroma1.academia.edu/MariaLeggio?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_79513174 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="79513174"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 79513174, container: ".js-paper-rank-work_79513174", }); });</script></li><li class="js-percentile-work_79513174 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79513174; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_79513174"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_79513174 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="79513174"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79513174; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79513174]").text(description); $(".js-view-count-work_79513174").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_79513174").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="79513174"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a>, <script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="129466" rel="nofollow" href="https://www.academia.edu/Documents/in/Sequence_Processing">Sequence Processing</a>, <script data-card-contents-for-ri="129466" type="text/json">{"id":129466,"name":"Sequence Processing","url":"https://www.academia.edu/Documents/in/Sequence_Processing?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="481010" rel="nofollow" href="https://www.academia.edu/Documents/in/Procedural_learning">Procedural learning</a><script data-card-contents-for-ri="481010" type="text/json">{"id":481010,"name":"Procedural learning","url":"https://www.academia.edu/Documents/in/Procedural_learning?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=79513174]'), work: {"id":79513174,"title":"A JOURNAL OF NEUROLOGY The cerebellar cognitive profile","created_at":"2022-05-20T05:13:10.401-07:00","url":"https://www.academia.edu/79513174/A_JOURNAL_OF_NEUROLOGY_The_cerebellar_cognitive_profile?f_ri=65615","dom_id":"work_79513174","summary":"The cerebellar role in non-motor functions is supported by the clinical finding that lesions confined to cerebellum produce the cerebellar cognitive affective syndrome. Nevertheless, there is no consensus regarding the overall cerebellar contribution to cognition. Among other reasons, this deficiency might be attributed to the small sample sizes and narrow breadths of existing studies on lesions in cerebellar patients, which have focused primarily on a single cognitive domain. The aim of this study was to examine the expression of cerebellar cognitive affective syndrome with regard to lesion topography in a large group of subjects with cerebellar damage. We retrospectively analysed charts from patients in the Ataxia Lab of Santa Lucia Foundation between 1997 and 2007. Of 223 charts, 156 were included in the study, focusing on the importance of the cerebellum in cognition and the relevance of lesion topography in defining the cognitive domains that have been affected. Vascular topog-...","downloadable_attachments":[{"id":86202724,"asset_id":79513174,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32689410,"first_name":"Maria","last_name":"Leggio","domain_name":"uniroma1","page_name":"MariaLeggio","display_name":"Maria Leggio","profile_url":"https://uniroma1.academia.edu/MariaLeggio?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":129466,"name":"Sequence Processing","url":"https://www.academia.edu/Documents/in/Sequence_Processing?f_ri=65615","nofollow":true},{"id":481010,"name":"Procedural learning","url":"https://www.academia.edu/Documents/in/Procedural_learning?f_ri=65615","nofollow":true},{"id":643228,"name":"Ataxia","url":"https://www.academia.edu/Documents/in/Ataxia?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27612110" data-work_id="27612110" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27612110/Working_Memory_and_Verbal_Fluency_Deficits_Following_Cerebellar_Lesions_Relation_to_Interindividual_Differences_in_Patient_Variables">Working Memory and Verbal Fluency Deficits Following Cerebellar Lesions: Relation to Interindividual Differences in Patient Variables</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Findings concerning cognitive impairment in patients with focal cerebellar lesions tend to be inconsistent and usually reflect a mild deficit. Patient variables such as lesion age and the age at lesion onset might affect functional... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27612110" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Findings concerning cognitive impairment in patients with focal cerebellar lesions tend to be inconsistent and usually reflect a mild deficit. Patient variables such as lesion age and the age at lesion onset might affect functional reorganization and contribute to the variability of the findings. To assess this issue, 14 patients with focal vascular cerebellar lesions and 14 matched healthy control subjects performed a verbal working memory and a verbal long-term memory task as well as verbal fluency tasks. Patients showed deficits in working memory and verbal fluency, while recall of complex narrative material was intact. Verbal fluency performance correlated significantly with age in the patient group, with more severe impairments in older patients, suggesting that age at lesion onset is a critical variable for cognitive outcome. In controls, no significant correlations with age were observed. Taken together, our findings support the idea of cerebellar involvement in nonmotor functions and indicate the relevance of interindividual differences in regard to clinical parameters after focal cerebellar damage.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27612110" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b63a345e1bde05271442a8fbf143b976" rel="nofollow" data-download="{"attachment_id":47877358,"asset_id":27612110,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47877358/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51808342" href="https://independent.academia.edu/JuttaPeterburs">Jutta Peterburs</a><script data-card-contents-for-user="51808342" type="text/json">{"id":51808342,"first_name":"Jutta","last_name":"Peterburs","domain_name":"independent","page_name":"JuttaPeterburs","display_name":"Jutta Peterburs","profile_url":"https://independent.academia.edu/JuttaPeterburs?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27612110 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27612110"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27612110, container: ".js-paper-rank-work_27612110", }); 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$(".js-view-count[data-work-id=27612110]").text(description); $(".js-view-count-work_27612110").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27612110").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27612110"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a>, <script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8538" rel="nofollow" href="https://www.academia.edu/Documents/in/Working_Memory">Working Memory</a>, <script data-card-contents-for-ri="8538" type="text/json">{"id":8538,"name":"Working Memory","url":"https://www.academia.edu/Documents/in/Working_Memory?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27612110]'), work: {"id":27612110,"title":"Working Memory and Verbal Fluency Deficits Following Cerebellar Lesions: Relation to Interindividual Differences in Patient Variables","created_at":"2016-08-07T23:52:53.203-07:00","url":"https://www.academia.edu/27612110/Working_Memory_and_Verbal_Fluency_Deficits_Following_Cerebellar_Lesions_Relation_to_Interindividual_Differences_in_Patient_Variables?f_ri=65615","dom_id":"work_27612110","summary":"Findings concerning cognitive impairment in patients with focal cerebellar lesions tend to be inconsistent and usually reflect a mild deficit. Patient variables such as lesion age and the age at lesion onset might affect functional reorganization and contribute to the variability of the findings. To assess this issue, 14 patients with focal vascular cerebellar lesions and 14 matched healthy control subjects performed a verbal working memory and a verbal long-term memory task as well as verbal fluency tasks. Patients showed deficits in working memory and verbal fluency, while recall of complex narrative material was intact. Verbal fluency performance correlated significantly with age in the patient group, with more severe impairments in older patients, suggesting that age at lesion onset is a critical variable for cognitive outcome. In controls, no significant correlations with age were observed. Taken together, our findings support the idea of cerebellar involvement in nonmotor functions and indicate the relevance of interindividual differences in regard to clinical parameters after focal cerebellar damage.","downloadable_attachments":[{"id":47877358,"asset_id":27612110,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51808342,"first_name":"Jutta","last_name":"Peterburs","domain_name":"independent","page_name":"JuttaPeterburs","display_name":"Jutta Peterburs","profile_url":"https://independent.academia.edu/JuttaPeterburs?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=65615","nofollow":true},{"id":8538,"name":"Working Memory","url":"https://www.academia.edu/Documents/in/Working_Memory?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":66080,"name":"Age","url":"https://www.academia.edu/Documents/in/Age?f_ri=65615"},{"id":85080,"name":"Verbal Fluency","url":"https://www.academia.edu/Documents/in/Verbal_Fluency?f_ri=65615"},{"id":124995,"name":"Verbal working memory","url":"https://www.academia.edu/Documents/in/Verbal_working_memory?f_ri=65615"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=65615"},{"id":341121,"name":"Cognitive impairment","url":"https://www.academia.edu/Documents/in/Cognitive_impairment?f_ri=65615"},{"id":522464,"name":"Short Term Memory","url":"https://www.academia.edu/Documents/in/Short_Term_Memory?f_ri=65615"},{"id":522465,"name":"Long Term Memory","url":"https://www.academia.edu/Documents/in/Long_Term_Memory?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=65615"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13442135" data-work_id="13442135" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13442135/p62_positive_TDP_43_negative_neuronal_cytoplasmic_and_intranuclear_inclusions_in_the_cerebellum_and_hippocampus_define_the_pathology_of_C9orf72_linked_FTLD_and_MND_ALS">p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Your article is protected by copyright and all rights are held exclusively by Springer-Verlag. 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You may further deposit the accepted author's version on a funder's repository at a funder's request, provided it is not made publicly available until 12 months after publication.","downloadable_attachments":[{"id":45338914,"asset_id":13442135,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32665064,"first_name":"Claire","last_name":"Troakes","domain_name":"kcl","page_name":"ClaireTroakes","display_name":"Claire Troakes","profile_url":"https://kcl.academia.edu/ClaireTroakes?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":42973,"name":"Amyotrophic Lateral Sclerosis","url":"https://www.academia.edu/Documents/in/Amyotrophic_Lateral_Sclerosis?f_ri=65615","nofollow":true},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA?f_ri=65615","nofollow":true},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=65615"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins?f_ri=65615"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":284067,"name":"Inclusion Bodies","url":"https://www.academia.edu/Documents/in/Inclusion_Bodies?f_ri=65615"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=65615"},{"id":426463,"name":"ACTA","url":"https://www.academia.edu/Documents/in/ACTA?f_ri=65615"},{"id":612554,"name":"Purkinje Cells","url":"https://www.academia.edu/Documents/in/Purkinje_Cells?f_ri=65615"},{"id":1186610,"name":"DNA binding proteins","url":"https://www.academia.edu/Documents/in/DNA_binding_proteins?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13753101" data-work_id="13753101" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13753101/Correlation_of_clinical_magnetic_resonance_imaging_and_cerebrospinal_fluid_findings_in_optic_neuritis">Correlation of clinical, magnetic resonance imaging, and cerebrospinal fluid findings in optic neuritis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We found 42 of 7 4 patients (57%) with isolated monosymptomatic optic neuritis to have 1 to 20 brain lesions, by magnetic resonance imaging (MRI). All of the brain lesions were clinically silent and had characteristics consistent with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13753101" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We found 42 of 7 4 patients (57%) with isolated monosymptomatic optic neuritis to have 1 to 20 brain lesions, by magnetic resonance imaging (MRI). All of the brain lesions were clinically silent and had characteristics consistent with multiple sclerosis (MS). None of the patients had ever experienced neurologic symptoms prior to the episode of optic neuritis. During 5.6 years of follow-up, 21 patients (28%) developed definite MS on clinical grounds. Sixteen of the 21 converting patients (76%) had abnormal MRIs; the other 5 (24%) had MRIs that were normal initially (when they had optic neuritis only) and when repeated after they had developed clinical MS in 4 of the 5. Of the 53 patients who have not developed clinically definite MS, 26 (49%) have abnormal MRIs and 27 (51%) have normal MRIs. The finding of an abnormal MRI at the time of optic neuritis was significantly related to the subsequent development of MS on clinical grounds, but interpretation of the strength of that relationship must be tempered by the fact that some of the converting patients had normal MFUs and approximately half of the patients who did not develop clinical MS had abnormal MRIs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13753101" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3513541e7a73b317f920afb3cb181bf4" rel="nofollow" data-download="{"attachment_id":44992455,"asset_id":13753101,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44992455/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32871407" href="https://spanalumni.academia.edu/LawrenceJacobs">Lawrence Jacobs</a><script data-card-contents-for-user="32871407" type="text/json">{"id":32871407,"first_name":"Lawrence","last_name":"Jacobs","domain_name":"spanalumni","page_name":"LawrenceJacobs","display_name":"Lawrence Jacobs","profile_url":"https://spanalumni.academia.edu/LawrenceJacobs?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13753101 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13753101"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13753101, container: ".js-paper-rank-work_13753101", }); });</script></li><li class="js-percentile-work_13753101 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13753101; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13753101"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13753101 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13753101"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13753101; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13753101]").text(description); $(".js-view-count-work_13753101").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13753101").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13753101"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3097" rel="nofollow" href="https://www.academia.edu/Documents/in/Multiple_sclerosis">Multiple sclerosis</a>, <script data-card-contents-for-ri="3097" type="text/json">{"id":3097,"name":"Multiple sclerosis","url":"https://www.academia.edu/Documents/in/Multiple_sclerosis?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="60971" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebrospinal_Fluid">Cerebrospinal Fluid</a><script data-card-contents-for-ri="60971" type="text/json">{"id":60971,"name":"Cerebrospinal Fluid","url":"https://www.academia.edu/Documents/in/Cerebrospinal_Fluid?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13753101]'), work: {"id":13753101,"title":"Correlation of clinical, magnetic resonance imaging, and cerebrospinal fluid findings in optic neuritis","created_at":"2015-07-07T08:55:54.862-07:00","url":"https://www.academia.edu/13753101/Correlation_of_clinical_magnetic_resonance_imaging_and_cerebrospinal_fluid_findings_in_optic_neuritis?f_ri=65615","dom_id":"work_13753101","summary":"We found 42 of 7 4 patients (57%) with isolated monosymptomatic optic neuritis to have 1 to 20 brain lesions, by magnetic resonance imaging (MRI). All of the brain lesions were clinically silent and had characteristics consistent with multiple sclerosis (MS). None of the patients had ever experienced neurologic symptoms prior to the episode of optic neuritis. During 5.6 years of follow-up, 21 patients (28%) developed definite MS on clinical grounds. Sixteen of the 21 converting patients (76%) had abnormal MRIs; the other 5 (24%) had MRIs that were normal initially (when they had optic neuritis only) and when repeated after they had developed clinical MS in 4 of the 5. Of the 53 patients who have not developed clinically definite MS, 26 (49%) have abnormal MRIs and 27 (51%) have normal MRIs. The finding of an abnormal MRI at the time of optic neuritis was significantly related to the subsequent development of MS on clinical grounds, but interpretation of the strength of that relationship must be tempered by the fact that some of the converting patients had normal MFUs and approximately half of the patients who did not develop clinical MS had abnormal MRIs.","downloadable_attachments":[{"id":44992455,"asset_id":13753101,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32871407,"first_name":"Lawrence","last_name":"Jacobs","domain_name":"spanalumni","page_name":"LawrenceJacobs","display_name":"Lawrence Jacobs","profile_url":"https://spanalumni.academia.edu/LawrenceJacobs?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3097,"name":"Multiple sclerosis","url":"https://www.academia.edu/Documents/in/Multiple_sclerosis?f_ri=65615","nofollow":true},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true},{"id":60971,"name":"Cerebrospinal Fluid","url":"https://www.academia.edu/Documents/in/Cerebrospinal_Fluid?f_ri=65615","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=65615"},{"id":315168,"name":"Optic Neuritis","url":"https://www.academia.edu/Documents/in/Optic_Neuritis?f_ri=65615"},{"id":710565,"name":"Annals","url":"https://www.academia.edu/Documents/in/Annals?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1716403,"name":"immunoglobulin G","url":"https://www.academia.edu/Documents/in/immunoglobulin_G?f_ri=65615"},{"id":2426000,"name":"Brain stem","url":"https://www.academia.edu/Documents/in/Brain_stem?f_ri=65615"},{"id":2439414,"name":"Magnetic resonance image","url":"https://www.academia.edu/Documents/in/Magnetic_resonance_image?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22420534" data-work_id="22420534" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22420534/Neural_tissue_compatibility_of_Teflon_as_an_implant_material_for_microvascular_decompression">Neural tissue compatibility of Teflon as an implant material for microvascular decompression</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Teflon is utilized in neurosurgery as well as in plastic, vascular and heart surgery. Although the effect of Teflon on different types of cells and tissues has been previously studied, we are not aware of any study in which the effect of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22420534" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Teflon is utilized in neurosurgery as well as in plastic, vascular and heart surgery. Although the effect of Teflon on different types of cells and tissues has been previously studied, we are not aware of any study in which the effect of Teflon was tested on cells of the central nervous system. We have therefore examined the tissue compatibility of spongy and fibrous Teflon by directly exposing the Teflon to dissociated cerebellar cells containing both glia and neurons in tissue culture. Daily examination of the growth of the cells adjacent to Teflon fibers using an inverted phase contrast microscope revealed that Teflon has little or no effect on the growth of these cells. When the cells are fixed after 7 days in culture and stained by the Jenner-Giemsa method, adhesion of both gila and neurons to the surface of the Teflon was seen. Attachment of neural cells to the Teflon was not extensive, as was shown by indirect immunofluorescence technique in connection with double-label staining with anti-GFAP as glia marker and anti-M6 as mouse neuron marker. Thus, these experiments show that Teflon is relatively inert when used as an implant in the central nervous system.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22420534" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1552bb86e8a269a00e1da35634041793" rel="nofollow" data-download="{"attachment_id":43043450,"asset_id":22420534,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43043450/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="43905412" href="https://independent.academia.edu/AhmedAmar6">Ahmed Amar</a><script data-card-contents-for-user="43905412" type="text/json">{"id":43905412,"first_name":"Ahmed","last_name":"Amar","domain_name":"independent","page_name":"AhmedAmar6","display_name":"Ahmed Amar","profile_url":"https://independent.academia.edu/AhmedAmar6?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22420534 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22420534"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22420534, container: ".js-paper-rank-work_22420534", }); });</script></li><li class="js-percentile-work_22420534 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22420534; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_22420534"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_22420534 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="22420534"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22420534; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22420534]").text(description); $(".js-view-count-work_22420534").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22420534").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22420534"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="647" rel="nofollow" href="https://www.academia.edu/Documents/in/Surgery">Surgery</a>, <script data-card-contents-for-ri="647" type="text/json">{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10055" rel="nofollow" href="https://www.academia.edu/Documents/in/Cell_Adhesion">Cell Adhesion</a>, <script data-card-contents-for-ri="10055" type="text/json">{"id":10055,"name":"Cell Adhesion","url":"https://www.academia.edu/Documents/in/Cell_Adhesion?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37782" rel="nofollow" href="https://www.academia.edu/Documents/in/Cell_Culture">Cell Culture</a>, <script data-card-contents-for-ri="37782" type="text/json">{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22420534]'), work: {"id":22420534,"title":"Neural tissue compatibility of Teflon as an implant material for microvascular decompression","created_at":"2016-02-25T02:32:08.774-08:00","url":"https://www.academia.edu/22420534/Neural_tissue_compatibility_of_Teflon_as_an_implant_material_for_microvascular_decompression?f_ri=65615","dom_id":"work_22420534","summary":"Teflon is utilized in neurosurgery as well as in plastic, vascular and heart surgery. Although the effect of Teflon on different types of cells and tissues has been previously studied, we are not aware of any study in which the effect of Teflon was tested on cells of the central nervous system. We have therefore examined the tissue compatibility of spongy and fibrous Teflon by directly exposing the Teflon to dissociated cerebellar cells containing both glia and neurons in tissue culture. Daily examination of the growth of the cells adjacent to Teflon fibers using an inverted phase contrast microscope revealed that Teflon has little or no effect on the growth of these cells. When the cells are fixed after 7 days in culture and stained by the Jenner-Giemsa method, adhesion of both gila and neurons to the surface of the Teflon was seen. Attachment of neural cells to the Teflon was not extensive, as was shown by indirect immunofluorescence technique in connection with double-label staining with anti-GFAP as glia marker and anti-M6 as mouse neuron marker. Thus, these experiments show that Teflon is relatively inert when used as an implant in the central nervous system.","downloadable_attachments":[{"id":43043450,"asset_id":22420534,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":43905412,"first_name":"Ahmed","last_name":"Amar","domain_name":"independent","page_name":"AhmedAmar6","display_name":"Ahmed Amar","profile_url":"https://independent.academia.edu/AhmedAmar6?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery?f_ri=65615","nofollow":true},{"id":10055,"name":"Cell Adhesion","url":"https://www.academia.edu/Documents/in/Cell_Adhesion?f_ri=65615","nofollow":true},{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":66089,"name":"Tissue culture","url":"https://www.academia.edu/Documents/in/Tissue_culture?f_ri=65615"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System?f_ri=65615"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":266618,"name":"Biomaterial","url":"https://www.academia.edu/Documents/in/Biomaterial?f_ri=65615"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=65615"},{"id":911984,"name":"Polytetrafluoroethylene","url":"https://www.academia.edu/Documents/in/Polytetrafluoroethylene?f_ri=65615"},{"id":1031067,"name":"Biocompatible Materials","url":"https://www.academia.edu/Documents/in/Biocompatible_Materials?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1698070,"name":"Heart Surgery","url":"https://www.academia.edu/Documents/in/Heart_Surgery?f_ri=65615"},{"id":2163893,"name":"Phase Contrast","url":"https://www.academia.edu/Documents/in/Phase_Contrast?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73964124" data-work_id="73964124" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73964124/Recessive_Ataxia_With_Ocular_Apraxia_Review_of_22_Portuguese_Patients">Recessive Ataxia With Ocular Apraxia: Review of 22 Portuguese Patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background The recessive ataxias are a heterogeneous group of neurodegenerative disorders characterized by cerebellar ataxia associated with a number of different neurologic, ophthalmologic, or general signs. They are often difficult to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73964124" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background The recessive ataxias are a heterogeneous group of neurodegenerative disorders characterized by cerebellar ataxia associated with a number of different neurologic, ophthalmologic, or general signs. They are often difficult to classify in clinical ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73964124" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="69cbb51d01d52e11ed1463f19a7187b6" rel="nofollow" data-download="{"attachment_id":82290170,"asset_id":73964124,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82290170/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="167194347" href="https://up-pt.academia.edu/BarrosJose">Jose Barros</a><script data-card-contents-for-user="167194347" type="text/json">{"id":167194347,"first_name":"Jose","last_name":"Barros","domain_name":"up-pt","page_name":"BarrosJose","display_name":"Jose Barros","profile_url":"https://up-pt.academia.edu/BarrosJose?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73964124 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73964124"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73964124, container: ".js-paper-rank-work_73964124", }); });</script></li><li class="js-percentile-work_73964124 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73964124; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73964124"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73964124 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73964124"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73964124; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73964124]").text(description); $(".js-view-count-work_73964124").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73964124").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73964124"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7513" rel="nofollow" href="https://www.academia.edu/Documents/in/Archives">Archives</a>, <script data-card-contents-for-ri="7513" type="text/json">{"id":7513,"name":"Archives","url":"https://www.academia.edu/Documents/in/Archives?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73964124]'), work: {"id":73964124,"title":"Recessive Ataxia With Ocular Apraxia: Review of 22 Portuguese Patients","created_at":"2022-03-17T11:47:49.488-07:00","url":"https://www.academia.edu/73964124/Recessive_Ataxia_With_Ocular_Apraxia_Review_of_22_Portuguese_Patients?f_ri=65615","dom_id":"work_73964124","summary":"Background The recessive ataxias are a heterogeneous group of neurodegenerative disorders characterized by cerebellar ataxia associated with a number of different neurologic, ophthalmologic, or general signs. They are often difficult to classify in clinical ...","downloadable_attachments":[{"id":82290170,"asset_id":73964124,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":167194347,"first_name":"Jose","last_name":"Barros","domain_name":"up-pt","page_name":"BarrosJose","display_name":"Jose Barros","profile_url":"https://up-pt.academia.edu/BarrosJose?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true},{"id":7513,"name":"Archives","url":"https://www.academia.edu/Documents/in/Archives?f_ri=65615","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true},{"id":44510,"name":"Portugal","url":"https://www.academia.edu/Documents/in/Portugal?f_ri=65615"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":188349,"name":"Pedigree","url":"https://www.academia.edu/Documents/in/Pedigree?f_ri=65615"},{"id":209780,"name":"Dystonia","url":"https://www.academia.edu/Documents/in/Dystonia?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":357850,"name":"Atrophy","url":"https://www.academia.edu/Documents/in/Atrophy?f_ri=65615"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1489115,"name":"Age of Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_51218128" data-work_id="51218128" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/51218128/ROS_scavenging_capacity_and_neuroprotective_effect_of_alpha_mangostin_against_3_nitropropionic_acid_in_cerebellar_granule_neurons">ROS scavenging capacity and neuroprotective effect of [alpha]-mangostin against 3-nitropropionic acid in cerebellar granule neurons</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">a-Mangostin is a xanthone with antioxidant properties isolated from mangosteen fruit. The reactive oxygen species (ROS) scavenging capacity and the potential protective effect of a-mangostin against the mitochondrial toxin... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_51218128" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">a-Mangostin is a xanthone with antioxidant properties isolated from mangosteen fruit. The reactive oxygen species (ROS) scavenging capacity and the potential protective effect of a-mangostin against the mitochondrial toxin 3-nitropropionic acid (3-NP) in primary cultures of cerebellar granule neurons (CGNs) were studied in the present work. It was found that a-mangostin was able to scavenge in a concentration-dependent way singlet oxygen, superoxide anion and peroxynitrite anion. In contrast, a-mangostin was unable to scavenge hydroxyl radicals and hydrogen peroxide. Furthermore, a-mangostin was able to ameliorate in a concentration-dependent way the neuronal death induced by 3-NP. This protective effect was associated with an amelioration of 3-NP-induced reactive oxygen species formation. It is concluded that a-mangostin is able to scavenge directly several ROS and has a neuroprotective effect against 3-NP in primary cultures of CGNs, which is associated with its ability to ameliorate 3-NP-induced ROS production.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/51218128" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e3231eca1bcd4e40c38663122d70ad31" rel="nofollow" data-download="{"attachment_id":69032944,"asset_id":51218128,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/69032944/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="181432871" href="https://independent.academia.edu/MarisolIbarra19">Marisol Ibarra</a><script data-card-contents-for-user="181432871" type="text/json">{"id":181432871,"first_name":"Marisol","last_name":"Ibarra","domain_name":"independent","page_name":"MarisolIbarra19","display_name":"Marisol Ibarra","profile_url":"https://independent.academia.edu/MarisolIbarra19?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_51218128 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="51218128"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 51218128, container: ".js-paper-rank-work_51218128", }); 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$(".js-view-count[data-work-id=51218128]").text(description); $(".js-view-count-work_51218128").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_51218128").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="51218128"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="37851" rel="nofollow" href="https://www.academia.edu/Documents/in/Neuroprotection">Neuroprotection</a>, <script data-card-contents-for-ri="37851" type="text/json">{"id":37851,"name":"Neuroprotection","url":"https://www.academia.edu/Documents/in/Neuroprotection?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="82978" rel="nofollow" href="https://www.academia.edu/Documents/in/Reactive_Oxygen_Species">Reactive Oxygen Species</a>, <script data-card-contents-for-ri="82978" type="text/json">{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="193974" rel="nofollow" href="https://www.academia.edu/Documents/in/Neurons">Neurons</a><script data-card-contents-for-ri="193974" type="text/json">{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=51218128]'), work: {"id":51218128,"title":"ROS scavenging capacity and neuroprotective effect of [alpha]-mangostin against 3-nitropropionic acid in cerebellar granule neurons","created_at":"2021-09-03T18:56:59.622-07:00","url":"https://www.academia.edu/51218128/ROS_scavenging_capacity_and_neuroprotective_effect_of_alpha_mangostin_against_3_nitropropionic_acid_in_cerebellar_granule_neurons?f_ri=65615","dom_id":"work_51218128","summary":"a-Mangostin is a xanthone with antioxidant properties isolated from mangosteen fruit. The reactive oxygen species (ROS) scavenging capacity and the potential protective effect of a-mangostin against the mitochondrial toxin 3-nitropropionic acid (3-NP) in primary cultures of cerebellar granule neurons (CGNs) were studied in the present work. It was found that a-mangostin was able to scavenge in a concentration-dependent way singlet oxygen, superoxide anion and peroxynitrite anion. In contrast, a-mangostin was unable to scavenge hydroxyl radicals and hydrogen peroxide. Furthermore, a-mangostin was able to ameliorate in a concentration-dependent way the neuronal death induced by 3-NP. This protective effect was associated with an amelioration of 3-NP-induced reactive oxygen species formation. It is concluded that a-mangostin is able to scavenge directly several ROS and has a neuroprotective effect against 3-NP in primary cultures of CGNs, which is associated with its ability to ameliorate 3-NP-induced ROS production.","downloadable_attachments":[{"id":69032944,"asset_id":51218128,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":181432871,"first_name":"Marisol","last_name":"Ibarra","domain_name":"independent","page_name":"MarisolIbarra19","display_name":"Marisol Ibarra","profile_url":"https://independent.academia.edu/MarisolIbarra19?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":37851,"name":"Neuroprotection","url":"https://www.academia.edu/Documents/in/Neuroprotection?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=65615","nofollow":true},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":274826,"name":"Hydrogen Peroxide","url":"https://www.academia.edu/Documents/in/Hydrogen_Peroxide?f_ri=65615"},{"id":329844,"name":"Experimental","url":"https://www.academia.edu/Documents/in/Experimental?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":396278,"name":"Neuronal Death","url":"https://www.academia.edu/Documents/in/Neuronal_Death?f_ri=65615"},{"id":541012,"name":"Singlet Oxygen","url":"https://www.academia.edu/Documents/in/Singlet_Oxygen?f_ri=65615"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=65615"},{"id":782254,"name":"Primary Culture","url":"https://www.academia.edu/Documents/in/Primary_Culture?f_ri=65615"},{"id":1035964,"name":"Superoxide Anion","url":"https://www.academia.edu/Documents/in/Superoxide_Anion?f_ri=65615"},{"id":1263993,"name":"Anion","url":"https://www.academia.edu/Documents/in/Anion?f_ri=65615"},{"id":1654784,"name":"Cerebellar Granule Neuron","url":"https://www.academia.edu/Documents/in/Cerebellar_Granule_Neuron?f_ri=65615"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents?f_ri=65615"},{"id":3043877,"name":"Xanthones","url":"https://www.academia.edu/Documents/in/Xanthones?f_ri=65615"},{"id":3724233,"name":"Hydroxyl Radical","url":"https://www.academia.edu/Documents/in/Hydroxyl_Radical?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13095969 coauthored" data-work_id="13095969" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13095969/Effects_of_cerebellectomy_on_motivation_related_behavior_a_time_course_study">Effects of cerebellectomy on motivation-related behavior: a time-course study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The open field behavior and learning capacity of male rats of the Wistar strain was studied 1, 2, and 6 months after cerebellectomy (CBX). The results show a decrease in locomotor activity 1 month after CBX and thereafter a slow recovery.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13095969" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The open field behavior and learning capacity of male rats of the Wistar strain was studied 1, 2, and 6 months after cerebellectomy (CBX). The results show a decrease in locomotor activity 1 month after CBX and thereafter a slow recovery. Grooming behavior was still normal after 1 month, but it decreased 2 months after CBX. Learning capacity, as assessed by the shuttle-box test, was remarkably decreased in cerebellectomized animals 1 month after operation. A significant impairment of memory capacity was also observed in rats tested for passive avoidance behavior 2 months after CBX. A partial recovery of this parameter was present 6 months after operation. These results support the hypothesis of a possible influence of cerebellum on motivation-related behaviors, independently of its modulatory role on motricity.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13095969" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="580ee277e1b2273b9bdc1f86b92058c9" rel="nofollow" data-download="{"attachment_id":45670850,"asset_id":13095969,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45670850/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32345559" href="https://independent.academia.edu/VDAgata">V. D'Agata</a><script data-card-contents-for-user="32345559" type="text/json">{"id":32345559,"first_name":"V.","last_name":"D'Agata","domain_name":"independent","page_name":"VDAgata","display_name":"V. D'Agata","profile_url":"https://independent.academia.edu/VDAgata?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-13095969">+1</span><div class="hidden js-additional-users-13095969"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://unict.academia.edu/FSerapide">F. 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The results show a decrease in locomotor activity 1 month after CBX and thereafter a slow recovery. Grooming behavior was still normal after 1 month, but it decreased 2 months after CBX. Learning capacity, as assessed by the shuttle-box test, was remarkably decreased in cerebellectomized animals 1 month after operation. A significant impairment of memory capacity was also observed in rats tested for passive avoidance behavior 2 months after CBX. A partial recovery of this parameter was present 6 months after operation. These results support the hypothesis of a possible influence of cerebellum on motivation-related behaviors, independently of its modulatory role on motricity.","downloadable_attachments":[{"id":45670850,"asset_id":13095969,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32345559,"first_name":"V.","last_name":"D'Agata","domain_name":"independent","page_name":"VDAgata","display_name":"V. D'Agata","profile_url":"https://independent.academia.edu/VDAgata?f_ri=65615","photo":"/images/s65_no_pic.png"},{"id":32786487,"first_name":"F.","last_name":"Serapide","domain_name":"unict","page_name":"FSerapide","display_name":"F. Serapide","profile_url":"https://unict.academia.edu/FSerapide?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":43774,"name":"Learning","url":"https://www.academia.edu/Documents/in/Learning?f_ri=65615","nofollow":true},{"id":46406,"name":"Motivation","url":"https://www.academia.edu/Documents/in/Motivation?f_ri=65615","nofollow":true},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=65615","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=65615","nofollow":true},{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":132020,"name":"Neuronal Plasticity","url":"https://www.academia.edu/Documents/in/Neuronal_Plasticity?f_ri=65615"},{"id":243672,"name":"Nerve Regeneration","url":"https://www.academia.edu/Documents/in/Nerve_Regeneration?f_ri=65615"},{"id":306766,"name":"Arousal","url":"https://www.academia.edu/Documents/in/Arousal?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":503238,"name":"Grooming","url":"https://www.academia.edu/Documents/in/Grooming?f_ri=65615"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=65615"},{"id":768867,"name":"Exploratory Behavior","url":"https://www.academia.edu/Documents/in/Exploratory_Behavior?f_ri=65615"},{"id":1315979,"name":"Time Course","url":"https://www.academia.edu/Documents/in/Time_Course?f_ri=65615"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity?f_ri=65615"},{"id":2451403,"name":"Avoidance Learning","url":"https://www.academia.edu/Documents/in/Avoidance_Learning?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14957276" data-work_id="14957276" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14957276/The_Cerebellum_and_Language_The_Story_So_Far">The Cerebellum and Language: The Story So Far</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">and sentence level); (3) naming and word finding difficulties; (4) cerebellar-induced aphasia; (5) reading difficulties; (6) writing problems, and (7) higher-level language deficits, including disturbed listening comprehension, impaired... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14957276" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">and sentence level); (3) naming and word finding difficulties; (4) cerebellar-induced aphasia; (5) reading difficulties; (6) writing problems, and (7) higher-level language deficits, including disturbed listening comprehension, impaired language proficiency and metalinguistic ability. Several hypotheses have been suggested to explain the nature of the cerebellar contribution to language. However, findings are not univocal. Conclusion: The cerebellum appears to be involved in a variety of linguistic functions. However, the precise nature of this contribution is not clear yet. Linguistic, neuroimaging, neuroanatomical and neuropsychological studies should be combined in order to disentangle the specific contribution of the cerebellum to linguistic processing.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14957276" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="aa1f37c18383875c431f08fef1f61147" rel="nofollow" data-download="{"attachment_id":43701857,"asset_id":14957276,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43701857/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33952472" href="https://independent.academia.edu/PhilippePaquier">Philippe Paquier</a><script data-card-contents-for-user="33952472" type="text/json">{"id":33952472,"first_name":"Philippe","last_name":"Paquier","domain_name":"independent","page_name":"PhilippePaquier","display_name":"Philippe Paquier","profile_url":"https://independent.academia.edu/PhilippePaquier?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14957276 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14957276"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14957276, container: ".js-paper-rank-work_14957276", }); 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$(".js-view-count[data-work-id=14957276]").text(description); $(".js-view-count-work_14957276").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14957276").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14957276"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="15674" rel="nofollow" href="https://www.academia.edu/Documents/in/Linguistics">Linguistics</a>, <script data-card-contents-for-ri="15674" type="text/json">{"id":15674,"name":"Linguistics","url":"https://www.academia.edu/Documents/in/Linguistics?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="18174" rel="nofollow" href="https://www.academia.edu/Documents/in/Language">Language</a>, <script data-card-contents-for-ri="18174" type="text/json">{"id":18174,"name":"Language","url":"https://www.academia.edu/Documents/in/Language?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28663" rel="nofollow" href="https://www.academia.edu/Documents/in/Language_disorders">Language disorders</a>, <script data-card-contents-for-ri="28663" type="text/json">{"id":28663,"name":"Language disorders","url":"https://www.academia.edu/Documents/in/Language_disorders?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14957276]'), work: {"id":14957276,"title":"The Cerebellum and Language: The Story So Far","created_at":"2015-08-16T08:33:41.253-07:00","url":"https://www.academia.edu/14957276/The_Cerebellum_and_Language_The_Story_So_Far?f_ri=65615","dom_id":"work_14957276","summary":"and sentence level); (3) naming and word finding difficulties; (4) cerebellar-induced aphasia; (5) reading difficulties; (6) writing problems, and (7) higher-level language deficits, including disturbed listening comprehension, impaired language proficiency and metalinguistic ability. Several hypotheses have been suggested to explain the nature of the cerebellar contribution to language. However, findings are not univocal. Conclusion: The cerebellum appears to be involved in a variety of linguistic functions. However, the precise nature of this contribution is not clear yet. Linguistic, neuroimaging, neuroanatomical and neuropsychological studies should be combined in order to disentangle the specific contribution of the cerebellum to linguistic processing.","downloadable_attachments":[{"id":43701857,"asset_id":14957276,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33952472,"first_name":"Philippe","last_name":"Paquier","domain_name":"independent","page_name":"PhilippePaquier","display_name":"Philippe Paquier","profile_url":"https://independent.academia.edu/PhilippePaquier?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":15674,"name":"Linguistics","url":"https://www.academia.edu/Documents/in/Linguistics?f_ri=65615","nofollow":true},{"id":18174,"name":"Language","url":"https://www.academia.edu/Documents/in/Language?f_ri=65615","nofollow":true},{"id":28663,"name":"Language disorders","url":"https://www.academia.edu/Documents/in/Language_disorders?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":249540,"name":"Language proficiency","url":"https://www.academia.edu/Documents/in/Language_proficiency?f_ri=65615"},{"id":916211,"name":"Literature Search","url":"https://www.academia.edu/Documents/in/Literature_Search?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73273961" data-work_id="73273961" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73273961/Domain_Organization_of_the_Type_1_Inositol_1_4_5_Trisphosphate_Receptor_As_Revealed_by_Single_Particle_Analysis">Domain Organization of the Type 1 Inositol 1, 4, 5-Trisphosphate Receptor As Revealed by Single-Particle Analysis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73273961" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3629e4f7d225a3954ffd750b7172d32d" rel="nofollow" data-download="{"attachment_id":81857540,"asset_id":73273961,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81857540/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="213084289" href="https://independent.academia.edu/PaulaFonseca95">Paula Fonseca</a><script data-card-contents-for-user="213084289" type="text/json">{"id":213084289,"first_name":"Paula","last_name":"Fonseca","domain_name":"independent","page_name":"PaulaFonseca95","display_name":"Paula Fonseca","profile_url":"https://independent.academia.edu/PaulaFonseca95?f_ri=65615","photo":"https://0.academia-photos.com/213084289/72054897/60511912/s65_paula.fonseca.png"}</script></span></span></li><li class="js-paper-rank-work_73273961 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73273961"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73273961, container: ".js-paper-rank-work_73273961", }); });</script></li><li class="js-percentile-work_73273961 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x 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}); });</script></span><script>$(function() { $(".js-view-count-work_73273961").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73273961"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2184" rel="nofollow" href="https://www.academia.edu/Documents/in/Electron_Microscopy">Electron Microscopy</a>, <script data-card-contents-for-ri="2184" type="text/json">{"id":2184,"name":"Electron Microscopy","url":"https://www.academia.edu/Documents/in/Electron_Microscopy?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="14076" rel="nofollow" href="https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy">Transmission Electron Microscopy</a>, <script data-card-contents-for-ri="14076" type="text/json">{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28235" rel="nofollow" href="https://www.academia.edu/Documents/in/Multidisciplinary">Multidisciplinary</a>, <script data-card-contents-for-ri="28235" type="text/json">{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="31084" rel="nofollow" href="https://www.academia.edu/Documents/in/Ion_Channels">Ion Channels</a><script data-card-contents-for-ri="31084" type="text/json">{"id":31084,"name":"Ion Channels","url":"https://www.academia.edu/Documents/in/Ion_Channels?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73273961]'), work: {"id":73273961,"title":"Domain Organization of the Type 1 Inositol 1, 4, 5-Trisphosphate Receptor As Revealed by Single-Particle Analysis","created_at":"2022-03-07T14:59:14.907-08:00","url":"https://www.academia.edu/73273961/Domain_Organization_of_the_Type_1_Inositol_1_4_5_Trisphosphate_Receptor_As_Revealed_by_Single_Particle_Analysis?f_ri=65615","dom_id":"work_73273961","summary":null,"downloadable_attachments":[{"id":81857540,"asset_id":73273961,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":213084289,"first_name":"Paula","last_name":"Fonseca","domain_name":"independent","page_name":"PaulaFonseca95","display_name":"Paula Fonseca","profile_url":"https://independent.academia.edu/PaulaFonseca95?f_ri=65615","photo":"https://0.academia-photos.com/213084289/72054897/60511912/s65_paula.fonseca.png"}],"research_interests":[{"id":2184,"name":"Electron Microscopy","url":"https://www.academia.edu/Documents/in/Electron_Microscopy?f_ri=65615","nofollow":true},{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy?f_ri=65615","nofollow":true},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=65615","nofollow":true},{"id":31084,"name":"Ion Channels","url":"https://www.academia.edu/Documents/in/Ion_Channels?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":99271,"name":"Calcium channels","url":"https://www.academia.edu/Documents/in/Calcium_channels?f_ri=65615"},{"id":122187,"name":"Endoplasmic Reticulum","url":"https://www.academia.edu/Documents/in/Endoplasmic_Reticulum?f_ri=65615"},{"id":146052,"name":"Ryanodine Receptor","url":"https://www.academia.edu/Documents/in/Ryanodine_Receptor?f_ri=65615"},{"id":372917,"name":"Protein Secondary Structure Prediction","url":"https://www.academia.edu/Documents/in/Protein_Secondary_Structure_Prediction?f_ri=65615"},{"id":653665,"name":"Protein Conformation","url":"https://www.academia.edu/Documents/in/Protein_Conformation?f_ri=65615"},{"id":793906,"name":"Single Particle Analysis","url":"https://www.academia.edu/Documents/in/Single_Particle_Analysis?f_ri=65615"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=65615"},{"id":1166930,"name":"Cytoplasm","url":"https://www.academia.edu/Documents/in/Cytoplasm?f_ri=65615"},{"id":2468093,"name":"Cell Membrane","url":"https://www.academia.edu/Documents/in/Cell_Membrane?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_64628708" data-work_id="64628708" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/64628708/The_White_Cerebellum_Sign_An_Under_Recognized_Sign_of_Increased_Intracranial_Pressure">The White Cerebellum Sign: An Under Recognized Sign of Increased Intracranial Pressure</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background The ''white cerebellum'' sign is a rare imaging finding described mainly in children with hypoxic brain injury. Materials and Methods Single case report and review of the literature. Findings We describe a child with acute... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_64628708" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background The ''white cerebellum'' sign is a rare imaging finding described mainly in children with hypoxic brain injury. Materials and Methods Single case report and review of the literature. Findings We describe a child with acute bacterial meningitis in whom plain CT and MRI showed the white cerebellum sign. The subtle imagings findings were not recognized and a lumbar puncture was performed. Markedly increased intracranial pressure was documented by lumbar puncture and by placement of an intraparenchymal monitor. Contrary to most prior descriptions the patient made a very good recovery. Conclusions The white cerebellum sign is a subtle imaging finding seen in patients with diffuse cerebral edema, such finding may not be as ominous as previously thought.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64628708" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8c1bf5383c9b38f96d13955d15134098" rel="nofollow" data-download="{"attachment_id":76576131,"asset_id":64628708,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76576131/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="186886669" href="https://independent.academia.edu/AngelaShapshak">Angela Shapshak</a><script data-card-contents-for-user="186886669" type="text/json">{"id":186886669,"first_name":"Angela","last_name":"Shapshak","domain_name":"independent","page_name":"AngelaShapshak","display_name":"Angela Shapshak","profile_url":"https://independent.academia.edu/AngelaShapshak?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_64628708 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="64628708"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 64628708, container: ".js-paper-rank-work_64628708", }); });</script></li><li class="js-percentile-work_64628708 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64628708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_64628708"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_64628708 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="64628708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64628708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64628708]").text(description); $(".js-view-count-work_64628708").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_64628708").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="64628708"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64628708]'), work: {"id":64628708,"title":"The White Cerebellum Sign: An Under Recognized Sign of Increased Intracranial Pressure","created_at":"2021-12-16T13:11:57.129-08:00","url":"https://www.academia.edu/64628708/The_White_Cerebellum_Sign_An_Under_Recognized_Sign_of_Increased_Intracranial_Pressure?f_ri=65615","dom_id":"work_64628708","summary":"Background The ''white cerebellum'' sign is a rare imaging finding described mainly in children with hypoxic brain injury. Materials and Methods Single case report and review of the literature. Findings We describe a child with acute bacterial meningitis in whom plain CT and MRI showed the white cerebellum sign. The subtle imagings findings were not recognized and a lumbar puncture was performed. Markedly increased intracranial pressure was documented by lumbar puncture and by placement of an intraparenchymal monitor. Contrary to most prior descriptions the patient made a very good recovery. Conclusions The white cerebellum sign is a subtle imaging finding seen in patients with diffuse cerebral edema, such finding may not be as ominous as previously thought.","downloadable_attachments":[{"id":76576131,"asset_id":64628708,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":186886669,"first_name":"Angela","last_name":"Shapshak","domain_name":"independent","page_name":"AngelaShapshak","display_name":"Angela Shapshak","profile_url":"https://independent.academia.edu/AngelaShapshak?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615","nofollow":true},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=65615"},{"id":976058,"name":"Intracranial Hypertension","url":"https://www.academia.edu/Documents/in/Intracranial_Hypertension?f_ri=65615"},{"id":1107128,"name":"Bacterial meningitis","url":"https://www.academia.edu/Documents/in/Bacterial_meningitis?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1254458,"name":"Neurocritical Care","url":"https://www.academia.edu/Documents/in/Neurocritical_Care?f_ri=65615"},{"id":1363401,"name":"Brain Edema","url":"https://www.academia.edu/Documents/in/Brain_Edema?f_ri=65615"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63061658" data-work_id="63061658" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63061658/Differential_Effects_of_Global_and_Cerebellar_Normalization_on_Detection_and_Differentiation_of_Dementia_In_FDG_PET_Studies">Differential Effects of Global and Cerebellar Normalization on Detection and Differentiation of Dementia In FDG-PET Studies</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">FDG-PET ([18F]fluorodeoxyglucose positron emission tomography) is frequently used to improve the differential diagnosis of dementia. However, a fundamental methodological issue of the reference area for the intensity normalization... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_63061658" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">FDG-PET ([18F]fluorodeoxyglucose positron emission tomography) is frequently used to improve the differential diagnosis of dementia. However, a fundamental methodological issue of the reference area for the intensity normalization procedure is still unsolved. Here, we systematically compared the two most commonly used normalization methods to the cerebral and to the cerebellar metabolic rate for glucose with regard to detection and differentiation of dementia syndromes. FDG-PET imaging was performed on 19 subjects with early Alzheimer&#x27;s disease, 13 subjects with early frontotemporal lobar degeneration and 10 subjects complaining of memory impairment, which had not been confirmed by comprehensive clinical testing. Images were normalized to either the cerebral or the cerebellar metabolic rate for glucose. Differences in relative regional glucose metabolism were assessed by voxelwise comparison. Analysis using the two normalization procedures revealed remarkable differential effec...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63061658" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3fe48691168c146530751a8111f149dd" rel="nofollow" data-download="{"attachment_id":75613968,"asset_id":63061658,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75613968/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33693543" href="https://cbs-mpg.academia.edu/HaraldMoeller">Harald Moeller</a><script data-card-contents-for-user="33693543" type="text/json">{"id":33693543,"first_name":"Harald","last_name":"Moeller","domain_name":"cbs-mpg","page_name":"HaraldMoeller","display_name":"Harald Moeller","profile_url":"https://cbs-mpg.academia.edu/HaraldMoeller?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_63061658 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="63061658"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 63061658, container: ".js-paper-rank-work_63061658", }); });</script></li><li class="js-percentile-work_63061658 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63061658; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_63061658"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_63061658 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="63061658"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63061658; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63061658]").text(description); $(".js-view-count-work_63061658").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_63061658").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63061658"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3662" rel="nofollow" href="https://www.academia.edu/Documents/in/Dementia">Dementia</a>, <script data-card-contents-for-ri="3662" type="text/json">{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52176" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain_Mapping">Brain Mapping</a>, <script data-card-contents-for-ri="52176" type="text/json">{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a>, <script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63061658]'), work: {"id":63061658,"title":"Differential Effects of Global and Cerebellar Normalization on Detection and Differentiation of Dementia In FDG-PET Studies","created_at":"2021-12-02T23:21:31.209-08:00","url":"https://www.academia.edu/63061658/Differential_Effects_of_Global_and_Cerebellar_Normalization_on_Detection_and_Differentiation_of_Dementia_In_FDG_PET_Studies?f_ri=65615","dom_id":"work_63061658","summary":"FDG-PET ([18F]fluorodeoxyglucose positron emission tomography) is frequently used to improve the differential diagnosis of dementia. However, a fundamental methodological issue of the reference area for the intensity normalization procedure is still unsolved. Here, we systematically compared the two most commonly used normalization methods to the cerebral and to the cerebellar metabolic rate for glucose with regard to detection and differentiation of dementia syndromes. FDG-PET imaging was performed on 19 subjects with early Alzheimer\u0026#x27;s disease, 13 subjects with early frontotemporal lobar degeneration and 10 subjects complaining of memory impairment, which had not been confirmed by comprehensive clinical testing. Images were normalized to either the cerebral or the cerebellar metabolic rate for glucose. Differences in relative regional glucose metabolism were assessed by voxelwise comparison. Analysis using the two normalization procedures revealed remarkable differential effec...","downloadable_attachments":[{"id":75613968,"asset_id":63061658,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33693543,"first_name":"Harald","last_name":"Moeller","domain_name":"cbs-mpg","page_name":"HaraldMoeller","display_name":"Harald Moeller","profile_url":"https://cbs-mpg.academia.edu/HaraldMoeller?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia?f_ri=65615","nofollow":true},{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=65615","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":71289,"name":"Glucose","url":"https://www.academia.edu/Documents/in/Glucose?f_ri=65615"},{"id":71431,"name":"Glucose Metabolism","url":"https://www.academia.edu/Documents/in/Glucose_Metabolism?f_ri=65615"},{"id":85366,"name":"ANOVA","url":"https://www.academia.edu/Documents/in/ANOVA?f_ri=65615"},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis?f_ri=65615"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=65615"},{"id":436755,"name":"Degeneration","url":"https://www.academia.edu/Documents/in/Degeneration?f_ri=65615"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=65615"},{"id":675221,"name":"Diagnostic Accuracy","url":"https://www.academia.edu/Documents/in/Diagnostic_Accuracy?f_ri=65615"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease?f_ri=65615"},{"id":1217494,"name":"Early Diagnosis","url":"https://www.academia.edu/Documents/in/Early_Diagnosis?f_ri=65615"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group?f_ri=65615"},{"id":1969155,"name":"Ad","url":"https://www.academia.edu/Documents/in/Ad?f_ri=65615"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49947650" data-work_id="49947650" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49947650/Combined_HIV_CMV_encephalitis_presenting_with_brainstem_signs">Combined HIV-CMV encephalitis presenting with brainstem signs</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Two cases ofcombined HIV-CMV encephalitis are described. One presented with a sixth nerve palsy and a tetraparesis, the other with an internuclear ophthalmoplegia. Pathologically brain stem involvement was predominantly due to CMV.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49947650" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2db5513c268bd06c09f72f9ed2c0d4b0" rel="nofollow" data-download="{"attachment_id":68115060,"asset_id":49947650,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68115060/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46607311" href="https://uchilefau.academia.edu/RGuiloff">R. Guiloff</a><script data-card-contents-for-user="46607311" type="text/json">{"id":46607311,"first_name":"R.","last_name":"Guiloff","domain_name":"uchilefau","page_name":"RGuiloff","display_name":"R. Guiloff","profile_url":"https://uchilefau.academia.edu/RGuiloff?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_49947650 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49947650"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49947650, container: ".js-paper-rank-work_49947650", }); });</script></li><li class="js-percentile-work_49947650 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 49947650; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_49947650"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_49947650 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="49947650"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 49947650; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=49947650]").text(description); $(".js-view-count-work_49947650").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_49947650").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="49947650"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="193974" rel="nofollow" href="https://www.academia.edu/Documents/in/Neurons">Neurons</a>, <script data-card-contents-for-ri="193974" type="text/json">{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="317801" rel="nofollow" href="https://www.academia.edu/Documents/in/Cell_nucleus">Cell nucleus</a>, <script data-card-contents-for-ri="317801" type="text/json">{"id":317801,"name":"Cell nucleus","url":"https://www.academia.edu/Documents/in/Cell_nucleus?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="448603" rel="nofollow" href="https://www.academia.edu/Documents/in/Necrosis">Necrosis</a><script data-card-contents-for-ri="448603" type="text/json">{"id":448603,"name":"Necrosis","url":"https://www.academia.edu/Documents/in/Necrosis?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=49947650]'), work: {"id":49947650,"title":"Combined HIV-CMV encephalitis presenting with brainstem signs","created_at":"2021-07-15T08:13:41.196-07:00","url":"https://www.academia.edu/49947650/Combined_HIV_CMV_encephalitis_presenting_with_brainstem_signs?f_ri=65615","dom_id":"work_49947650","summary":"Two cases ofcombined HIV-CMV encephalitis are described. One presented with a sixth nerve palsy and a tetraparesis, the other with an internuclear ophthalmoplegia. Pathologically brain stem involvement was predominantly due to CMV.","downloadable_attachments":[{"id":68115060,"asset_id":49947650,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46607311,"first_name":"R.","last_name":"Guiloff","domain_name":"uchilefau","page_name":"RGuiloff","display_name":"R. Guiloff","profile_url":"https://uchilefau.academia.edu/RGuiloff?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615","nofollow":true},{"id":317801,"name":"Cell nucleus","url":"https://www.academia.edu/Documents/in/Cell_nucleus?f_ri=65615","nofollow":true},{"id":448603,"name":"Necrosis","url":"https://www.academia.edu/Documents/in/Necrosis?f_ri=65615","nofollow":true},{"id":699649,"name":"Cytomegalovirus Infections","url":"https://www.academia.edu/Documents/in/Cytomegalovirus_Infections?f_ri=65615"},{"id":1109079,"name":"Encephalitis","url":"https://www.academia.edu/Documents/in/Encephalitis?f_ri=65615"},{"id":1171388,"name":"Ophthalmoplegia","url":"https://www.academia.edu/Documents/in/Ophthalmoplegia?f_ri=65615"},{"id":1938362,"name":"Acquired immunodeficiency syndrome","url":"https://www.academia.edu/Documents/in/Acquired_immunodeficiency_syndrome?f_ri=65615"},{"id":2426000,"name":"Brain stem","url":"https://www.academia.edu/Documents/in/Brain_stem?f_ri=65615"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences?f_ri=65615"},{"id":3080490,"name":"Opportunistic Infections","url":"https://www.academia.edu/Documents/in/Opportunistic_Infections?f_ri=65615"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48590896" data-work_id="48590896" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48590896/Correlation_of_nitric_oxide_levels_in_the_cerebellum_and_spinal_cord_of_experimental_autoimmune_encephalomyelitis_rats_with_clinical_symptoms">Correlation of nitric oxide levels in the cerebellum and spinal cord of experimental autoimmune encephalomyelitis rats with clinical symptoms</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Experimental autoimmune encephalomyelitis (EAE) is a well-established cell-mediated autoimmune inflammatory disease of the CNS, which has been used as a model of the human demyelinating disease. EAE is characterized by infiltration of the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_48590896" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Experimental autoimmune encephalomyelitis (EAE) is a well-established cell-mediated autoimmune inflammatory disease of the CNS, which has been used as a model of the human demyelinating disease. EAE is characterized by infiltration of the CNS by lymphocytes and mononuclear cells, microglial and astrocytic hypertrophy, and demyelination which cumulatively contribute to clinical expression of the disease. EAE was induced in female Sprague-Dawley rats, 3 months old (300 g ± 20 g), by immunization with myelin basic protein (MBP) in combination with Complete Freund's adjuvant (CFA). The animals were divided into 7 groups: control, EAE, CFA, EAE + aminoguanidine (AG), AG, EAE + N-acetyl-L-cysteine (NAC) and NAC. The animals were sacrificed 15 days after EAE induction, and the level of nitric oxide (NO(·)) production was determined by measuring nitrite and nitrate concentrations in 10% homogenate of cerebellum and spinal cord. Obtained results showed that the level of NO(·) was significantly increased in all examined tissues of the EAE rats compared to the control and CFA groups. Also, AG and NAC treatment decreased the level of NO(·) in all tissues compared to the EAE group. The level of NO(·) is increased significantly in the spinal cord compared to the cerebellum. The clinical course of the EAE was significantly decreased in the EAE groups treated with AG and NAC during the development of the disease compared to EAE group and its correlates with the NO(·) level in cerebellum and spinal cord. The findings of our work suggest that NO(·) and its derivatives play an important role in multiple sclerosis (MS). It may be the best target for new therapies in human demyelinating disease and recommend the new therapeutic approaches based on a decreased level of NO(·) during the course of MS.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48590896" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bfb1018f01a0a9f8c51813f0dcfa10f1" rel="nofollow" data-download="{"attachment_id":67123615,"asset_id":48590896,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67123615/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35632883" href="https://independent.academia.edu/IvanaStojanovic6">Ivana Stojanovic</a><script data-card-contents-for-user="35632883" type="text/json">{"id":35632883,"first_name":"Ivana","last_name":"Stojanovic","domain_name":"independent","page_name":"IvanaStojanovic6","display_name":"Ivana Stojanovic","profile_url":"https://independent.academia.edu/IvanaStojanovic6?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_48590896 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48590896"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48590896, container: ".js-paper-rank-work_48590896", }); });</script></li><li class="js-percentile-work_48590896 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48590896; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_48590896"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_48590896 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="48590896"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48590896; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48590896]").text(description); $(".js-view-count-work_48590896").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48590896").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48590896"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="93922" rel="nofollow" href="https://www.academia.edu/Documents/in/Nitric_oxide">Nitric oxide</a><script data-card-contents-for-ri="93922" type="text/json">{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48590896]'), work: {"id":48590896,"title":"Correlation of nitric oxide levels in the cerebellum and spinal cord of experimental autoimmune encephalomyelitis rats with clinical symptoms","created_at":"2021-05-05T00:00:01.939-07:00","url":"https://www.academia.edu/48590896/Correlation_of_nitric_oxide_levels_in_the_cerebellum_and_spinal_cord_of_experimental_autoimmune_encephalomyelitis_rats_with_clinical_symptoms?f_ri=65615","dom_id":"work_48590896","summary":"Experimental autoimmune encephalomyelitis (EAE) is a well-established cell-mediated autoimmune inflammatory disease of the CNS, which has been used as a model of the human demyelinating disease. EAE is characterized by infiltration of the CNS by lymphocytes and mononuclear cells, microglial and astrocytic hypertrophy, and demyelination which cumulatively contribute to clinical expression of the disease. EAE was induced in female Sprague-Dawley rats, 3 months old (300 g ± 20 g), by immunization with myelin basic protein (MBP) in combination with Complete Freund's adjuvant (CFA). The animals were divided into 7 groups: control, EAE, CFA, EAE + aminoguanidine (AG), AG, EAE + N-acetyl-L-cysteine (NAC) and NAC. The animals were sacrificed 15 days after EAE induction, and the level of nitric oxide (NO(·)) production was determined by measuring nitrite and nitrate concentrations in 10% homogenate of cerebellum and spinal cord. Obtained results showed that the level of NO(·) was significantly increased in all examined tissues of the EAE rats compared to the control and CFA groups. Also, AG and NAC treatment decreased the level of NO(·) in all tissues compared to the EAE group. The level of NO(·) is increased significantly in the spinal cord compared to the cerebellum. The clinical course of the EAE was significantly decreased in the EAE groups treated with AG and NAC during the development of the disease compared to EAE group and its correlates with the NO(·) level in cerebellum and spinal cord. The findings of our work suggest that NO(·) and its derivatives play an important role in multiple sclerosis (MS). It may be the best target for new therapies in human demyelinating disease and recommend the new therapeutic approaches based on a decreased level of NO(·) during the course of MS.","downloadable_attachments":[{"id":67123615,"asset_id":48590896,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35632883,"first_name":"Ivana","last_name":"Stojanovic","domain_name":"independent","page_name":"IvanaStojanovic6","display_name":"Ivana Stojanovic","profile_url":"https://independent.academia.edu/IvanaStojanovic6?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=65615","nofollow":true},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=65615","nofollow":true},{"id":99421,"name":"Spinal Cord","url":"https://www.academia.edu/Documents/in/Spinal_Cord?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":788681,"name":"N-Acetylcysteine","url":"https://www.academia.edu/Documents/in/N-Acetylcysteine?f_ri=65615"},{"id":989400,"name":"Experimental Autoimmune Encephalomyelitis","url":"https://www.academia.edu/Documents/in/Experimental_Autoimmune_Encephalomyelitis?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":3881612,"name":"myelin basic protein","url":"https://www.academia.edu/Documents/in/myelin_basic_protein?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5045878" data-work_id="5045878" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5045878/Pure_post_stroke_cerebellar_cognitive_affective_syndrome_a_case_report">Pure post–stroke cerebellar cognitive affective syndrome: a case report</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cerebellar pathology commonly shows important motor signs and less evident cognitive dysfunction. The ’cerebellar cognitive affective syndrome’ is characterised by impairment on executive function, spatial cognition, language and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5045878" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cerebellar pathology commonly shows important motor signs and less evident cognitive dysfunction. The ’cerebellar cognitive affective syndrome’ is characterised by impairment on executive function, spatial cognition, language and behaviour. We report the case of a man with acute onset of transitory motor features and severe mental disorders. Cranial CT and brain MRI revealed extended cerebellar lesions. Neuropsychological assessment disclosed deficits of attention, executive function and memory. Auditory event–related potentials showed abnormal P300. These data suggest a pure “cerebellar cognitive affective syndrome” and strengthen the hypothesis of cerebellar cognitive function modulation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5045878" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4aad679204efa50c5e5a0e67c5add93e" rel="nofollow" data-download="{"attachment_id":49472578,"asset_id":5045878,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49472578/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6724828" href="https://uniss.academia.edu/ImmacolataMagnano">Immacolata Magnano</a><script data-card-contents-for-user="6724828" type="text/json">{"id":6724828,"first_name":"Immacolata","last_name":"Magnano","domain_name":"uniss","page_name":"ImmacolataMagnano","display_name":"Immacolata Magnano","profile_url":"https://uniss.academia.edu/ImmacolataMagnano?f_ri=65615","photo":"https://0.academia-photos.com/6724828/9806683/10927307/s65_immacolata.magnano.jpg_oh_f6e1e648d74de274e08db0706ef3e581_oe_5628002b___gda___1448917934_adc400418b44677c28a631e202432754"}</script></span></span></li><li class="js-paper-rank-work_5045878 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5045878"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5045878, container: ".js-paper-rank-work_5045878", }); });</script></li><li class="js-percentile-work_5045878 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5045878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_5045878"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_5045878 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="5045878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5045878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5045878]").text(description); $(".js-view-count-work_5045878").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_5045878").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="5045878"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">21</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2973" rel="nofollow" href="https://www.academia.edu/Documents/in/Spatial_cognition">Spatial cognition</a>, <script data-card-contents-for-ri="2973" type="text/json">{"id":2973,"name":"Spatial cognition","url":"https://www.academia.edu/Documents/in/Spatial_cognition?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7736" rel="nofollow" href="https://www.academia.edu/Documents/in/Attention">Attention</a>, <script data-card-contents-for-ri="7736" type="text/json">{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28663" rel="nofollow" href="https://www.academia.edu/Documents/in/Language_disorders">Language disorders</a><script data-card-contents-for-ri="28663" type="text/json">{"id":28663,"name":"Language disorders","url":"https://www.academia.edu/Documents/in/Language_disorders?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5045878]'), work: {"id":5045878,"title":"Pure post–stroke cerebellar cognitive affective syndrome: a case report","created_at":"2013-11-09T20:00:09.281-08:00","url":"https://www.academia.edu/5045878/Pure_post_stroke_cerebellar_cognitive_affective_syndrome_a_case_report?f_ri=65615","dom_id":"work_5045878","summary":"Cerebellar pathology commonly shows important motor signs and less evident cognitive dysfunction. The ’cerebellar cognitive affective syndrome’ is characterised by impairment on executive function, spatial cognition, language and behaviour. We report the case of a man with acute onset of transitory motor features and severe mental disorders. Cranial CT and brain MRI revealed extended cerebellar lesions. Neuropsychological assessment disclosed deficits of attention, executive function and memory. Auditory event–related potentials showed abnormal P300. These data suggest a pure “cerebellar cognitive affective syndrome” and strengthen the hypothesis of cerebellar cognitive function modulation.","downloadable_attachments":[{"id":49472578,"asset_id":5045878,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6724828,"first_name":"Immacolata","last_name":"Magnano","domain_name":"uniss","page_name":"ImmacolataMagnano","display_name":"Immacolata Magnano","profile_url":"https://uniss.academia.edu/ImmacolataMagnano?f_ri=65615","photo":"https://0.academia-photos.com/6724828/9806683/10927307/s65_immacolata.magnano.jpg_oh_f6e1e648d74de274e08db0706ef3e581_oe_5628002b___gda___1448917934_adc400418b44677c28a631e202432754"}],"research_interests":[{"id":2973,"name":"Spatial cognition","url":"https://www.academia.edu/Documents/in/Spatial_cognition?f_ri=65615","nofollow":true},{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true},{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=65615","nofollow":true},{"id":28663,"name":"Language disorders","url":"https://www.academia.edu/Documents/in/Language_disorders?f_ri=65615","nofollow":true},{"id":33732,"name":"Executive Function","url":"https://www.academia.edu/Documents/in/Executive_Function?f_ri=65615"},{"id":61234,"name":"Stroke","url":"https://www.academia.edu/Documents/in/Stroke?f_ri=65615"},{"id":63886,"name":"Case Report","url":"https://www.academia.edu/Documents/in/Case_Report?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":97764,"name":"Neuropsychological Assessment","url":"https://www.academia.edu/Documents/in/Neuropsychological_Assessment?f_ri=65615"},{"id":211445,"name":"Mental Disorder","url":"https://www.academia.edu/Documents/in/Mental_Disorder?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":264670,"name":"Neurological","url":"https://www.academia.edu/Documents/in/Neurological?f_ri=65615"},{"id":284201,"name":"Mood Disorders","url":"https://www.academia.edu/Documents/in/Mood_Disorders?f_ri=65615"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=65615"},{"id":441653,"name":"Cognitive Function","url":"https://www.academia.edu/Documents/in/Cognitive_Function?f_ri=65615"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=65615"},{"id":974411,"name":"Memory Disorders","url":"https://www.academia.edu/Documents/in/Memory_Disorders?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=65615"},{"id":2449252,"name":"Neurological Sciences","url":"https://www.academia.edu/Documents/in/Neurological_Sciences?f_ri=65615"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10256460" data-work_id="10256460" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10256460/The_density_and_distribution_of_ischemic_brain_injury_in_the_rat_following_2_10_min_of_forebrain_ischemia">The density and distribution of ischemic brain injury in the rat following 2–10 min of forebrain ischemia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The density and distribution of brain damage after 2–10 min of cerebral ischemia was studied in the rat. Ischemia was produced by a combination of carotid clamping and hypotension, followed by 1 week recovery. The brains were... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10256460" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The density and distribution of brain damage after 2–10 min of cerebral ischemia was studied in the rat. Ischemia was produced by a combination of carotid clamping and hypotension, followed by 1 week recovery. The brains were perfusion-fixed with formaldehyde, embedded in paraffin, subserially sectioned, and stained with acid fuchsin/cresyl violet. The number of necrotic neurons in the cerebral cortex, hippocampus, and caudate nucleus was assessed by direct visual counting. Somewhat unexpectedly, mild brain damage was observed in some animals already after 2 min, and more consistently after 4 min of ischemia. This damage affected CA4 and CA1 pyramids in the hippocampus, and neurons in the subiculum. Necrosis of neocortical cells began to appear after 4 min and CA3 hippocampal damage after 6 min of ischemia, while neurons in the caudoputamen were affected first after 8–10 min. Selective neuronal necrosis of the cerebral cortex worsened into infarction after higher doses of insult. Damage was worst over the superolateral convexity of the hemisphere, in the middle laminae of the cerebral cortex. The caudate nucleus showed geographically demarcated zones of selective neuronal necrosis, damage to neurons in the dorsolateral portion showing an all-or-none pattern. Other structures involved included the amygdaloid, the thalamic reticular nucleus, the septal nuclei, the pars reticularis of the substantia nigra, and the cerebellar vermis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10256460" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3dd696616aa7379efcb3e5a4e6c6eedf" rel="nofollow" data-download="{"attachment_id":47466153,"asset_id":10256460,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47466153/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="25110855" href="https://independent.academia.edu/BoAT">Bo AT</a><script data-card-contents-for-user="25110855" type="text/json">{"id":25110855,"first_name":"Bo","last_name":"AT","domain_name":"independent","page_name":"BoAT","display_name":"Bo AT","profile_url":"https://independent.academia.edu/BoAT?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_10256460 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10256460"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10256460, container: ".js-paper-rank-work_10256460", }); });</script></li><li class="js-percentile-work_10256460 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 10256460; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_10256460"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_10256460 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="10256460"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 10256460; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=10256460]").text(description); $(".js-view-count-work_10256460").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_10256460").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="10256460"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="57556" rel="nofollow" href="https://www.academia.edu/Documents/in/Hippocampus">Hippocampus</a>, <script data-card-contents-for-ri="57556" type="text/json">{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a>, <script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65637" rel="nofollow" href="https://www.academia.edu/Documents/in/Caudate_Nucleus">Caudate Nucleus</a><script data-card-contents-for-ri="65637" type="text/json">{"id":65637,"name":"Caudate Nucleus","url":"https://www.academia.edu/Documents/in/Caudate_Nucleus?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=10256460]'), work: {"id":10256460,"title":"The density and distribution of ischemic brain injury in the rat following 2–10 min of forebrain ischemia","created_at":"2015-01-20T21:43:54.331-08:00","url":"https://www.academia.edu/10256460/The_density_and_distribution_of_ischemic_brain_injury_in_the_rat_following_2_10_min_of_forebrain_ischemia?f_ri=65615","dom_id":"work_10256460","summary":"The density and distribution of brain damage after 2–10 min of cerebral ischemia was studied in the rat. Ischemia was produced by a combination of carotid clamping and hypotension, followed by 1 week recovery. The brains were perfusion-fixed with formaldehyde, embedded in paraffin, subserially sectioned, and stained with acid fuchsin/cresyl violet. The number of necrotic neurons in the cerebral cortex, hippocampus, and caudate nucleus was assessed by direct visual counting. Somewhat unexpectedly, mild brain damage was observed in some animals already after 2 min, and more consistently after 4 min of ischemia. This damage affected CA4 and CA1 pyramids in the hippocampus, and neurons in the subiculum. Necrosis of neocortical cells began to appear after 4 min and CA3 hippocampal damage after 6 min of ischemia, while neurons in the caudoputamen were affected first after 8–10 min. Selective neuronal necrosis of the cerebral cortex worsened into infarction after higher doses of insult. Damage was worst over the superolateral convexity of the hemisphere, in the middle laminae of the cerebral cortex. The caudate nucleus showed geographically demarcated zones of selective neuronal necrosis, damage to neurons in the dorsolateral portion showing an all-or-none pattern. Other structures involved included the amygdaloid, the thalamic reticular nucleus, the septal nuclei, the pars reticularis of the substantia nigra, and the cerebellar vermis.","downloadable_attachments":[{"id":47466153,"asset_id":10256460,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":25110855,"first_name":"Bo","last_name":"AT","domain_name":"independent","page_name":"BoAT","display_name":"Bo AT","profile_url":"https://independent.academia.edu/BoAT?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=65615","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":65637,"name":"Caudate Nucleus","url":"https://www.academia.edu/Documents/in/Caudate_Nucleus?f_ri=65615","nofollow":true},{"id":66228,"name":"Thalamus","url":"https://www.academia.edu/Documents/in/Thalamus?f_ri=65615"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex?f_ri=65615"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death?f_ri=65615"},{"id":172827,"name":"Brain Ischemia","url":"https://www.academia.edu/Documents/in/Brain_Ischemia?f_ri=65615"},{"id":207421,"name":"Brain injury","url":"https://www.academia.edu/Documents/in/Brain_injury?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=65615"},{"id":541092,"name":"Cerebral Ischemia","url":"https://www.academia.edu/Documents/in/Cerebral_Ischemia?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1431361,"name":"Brain Damage","url":"https://www.academia.edu/Documents/in/Brain_Damage?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27114106" data-work_id="27114106" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27114106/Novelty_detector_neurons_in_the_mammalian_auditory_midbrain">Novelty detector neurons in the mammalian auditory midbrain</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Novel stimuli in all sensory modalities are highly effective in attracting and focusing attention. Stimulus-specific adaptation (SSA) and brain activity evoked by novel stimuli have been studied using population measures such as imaging... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27114106" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Novel stimuli in all sensory modalities are highly effective in attracting and focusing attention. Stimulus-specific adaptation (SSA) and brain activity evoked by novel stimuli have been studied using population measures such as imaging and event-related potentials, but there have been few studies at the single-neuron level. In this study we compare SSA across different populations of neurons in the inferior colliculus (IC) of the rat and show that a subclass of neurons with rapid and pronounced SSA respond selectively to novel sounds. These neurons, located in the dorsal and external cortex of the IC, fail to respond to multiple repetitions of a sound but briefly recover their excitability when some stimulus parameter is changed. The finding of neurons that respond selectively to novel stimuli in the mammalian auditory midbrain suggests that they may contribute to a rapid subcortical pathway for directing attention and ⁄ or orienting responses to novel sounds.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27114106" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="00b9ea7f9d684641750a8a621c2e2edd" rel="nofollow" data-download="{"attachment_id":47364292,"asset_id":27114106,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47364292/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35887782" href="https://independent.academia.edu/CoveyE">E. Covey</a><script data-card-contents-for-user="35887782" type="text/json">{"id":35887782,"first_name":"E.","last_name":"Covey","domain_name":"independent","page_name":"CoveyE","display_name":"E. Covey","profile_url":"https://independent.academia.edu/CoveyE?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27114106 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27114106"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27114106, container: ".js-paper-rank-work_27114106", }); });</script></li><li class="js-percentile-work_27114106 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27114106; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_27114106"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_27114106 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="27114106"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27114106; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27114106]").text(description); $(".js-view-count-work_27114106").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27114106").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27114106"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2007" rel="nofollow" href="https://www.academia.edu/Documents/in/Electrophysiology">Electrophysiology</a>, <script data-card-contents-for-ri="2007" type="text/json">{"id":2007,"name":"Electrophysiology","url":"https://www.academia.edu/Documents/in/Electrophysiology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7736" rel="nofollow" href="https://www.academia.edu/Documents/in/Attention">Attention</a><script data-card-contents-for-ri="7736" type="text/json">{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27114106]'), work: {"id":27114106,"title":"Novelty detector neurons in the mammalian auditory midbrain","created_at":"2016-07-19T17:13:43.037-07:00","url":"https://www.academia.edu/27114106/Novelty_detector_neurons_in_the_mammalian_auditory_midbrain?f_ri=65615","dom_id":"work_27114106","summary":"Novel stimuli in all sensory modalities are highly effective in attracting and focusing attention. Stimulus-specific adaptation (SSA) and brain activity evoked by novel stimuli have been studied using population measures such as imaging and event-related potentials, but there have been few studies at the single-neuron level. In this study we compare SSA across different populations of neurons in the inferior colliculus (IC) of the rat and show that a subclass of neurons with rapid and pronounced SSA respond selectively to novel sounds. These neurons, located in the dorsal and external cortex of the IC, fail to respond to multiple repetitions of a sound but briefly recover their excitability when some stimulus parameter is changed. The finding of neurons that respond selectively to novel stimuli in the mammalian auditory midbrain suggests that they may contribute to a rapid subcortical pathway for directing attention and ⁄ or orienting responses to novel sounds.","downloadable_attachments":[{"id":47364292,"asset_id":27114106,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35887782,"first_name":"E.","last_name":"Covey","domain_name":"independent","page_name":"CoveyE","display_name":"E. Covey","profile_url":"https://independent.academia.edu/CoveyE?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=65615","nofollow":true},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true},{"id":2007,"name":"Electrophysiology","url":"https://www.academia.edu/Documents/in/Electrophysiology?f_ri=65615","nofollow":true},{"id":7736,"name":"Attention","url":"https://www.academia.edu/Documents/in/Attention?f_ri=65615","nofollow":true},{"id":58520,"name":"Habituation","url":"https://www.academia.edu/Documents/in/Habituation?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":569037,"name":"Auditory evoked Potentials","url":"https://www.academia.edu/Documents/in/Auditory_evoked_Potentials?f_ri=65615"},{"id":723371,"name":"Auditory Cortex","url":"https://www.academia.edu/Documents/in/Auditory_Cortex?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1505827,"name":"Inferior Colliculus","url":"https://www.academia.edu/Documents/in/Inferior_Colliculus?f_ri=65615"},{"id":2351341,"name":"Orienting Response","url":"https://www.academia.edu/Documents/in/Orienting_Response?f_ri=65615"},{"id":2428413,"name":"Acoustic Stimulation","url":"https://www.academia.edu/Documents/in/Acoustic_Stimulation?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25128157" data-work_id="25128157" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25128157/Abnormal_Neuronal_Expression_of_the_Calcium_binding_Proteins_Parvalbumin_and_Calbindin_D_28k_in_Aged_Dogs">Abnormal Neuronal Expression of the Calcium-binding Proteins, Parvalbumin and Calbindin D-28k, in Aged Dogs</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Disturbances of the g-aminobutyric acid (GABA) neurotransmitter system have been implicated in chronic degenerative neurological disease. Cognitive dysfunction and neuron loss are features in older dogs. GABAergic neurons also show... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25128157" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Disturbances of the g-aminobutyric acid (GABA) neurotransmitter system have been implicated in chronic degenerative neurological disease. Cognitive dysfunction and neuron loss are features in older dogs. GABAergic neurons also show immunoreactivity for specific calcium-binding proteins. Immunohistochemistry was used to study the neuronal expression of calbindin D-28k and parvalbumin in different areas of the brain in 13 dogs, aged between 2 and 13Á5 years. Calbindin expression was found only in the cerebellum. There were significant differences in the quantity and distribution of neurons expressing these proteins between geriatric and adult brains. Parvalbumin-and calbindin-expressing neurons are relatively sensitive to degeneration in the cerebellum of older dogs. Parvalbumin labelling was associated with dystrophic structures that are commonly associated with ageing.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25128157" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="536a9b6bf34bbee995fcc0d1f3efc292" rel="nofollow" data-download="{"attachment_id":45448826,"asset_id":25128157,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45448826/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="48404443" href="https://independent.academia.edu/VidalEnric">Enric Vidal</a><script data-card-contents-for-user="48404443" type="text/json">{"id":48404443,"first_name":"Enric","last_name":"Vidal","domain_name":"independent","page_name":"VidalEnric","display_name":"Enric Vidal","profile_url":"https://independent.academia.edu/VidalEnric?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25128157 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25128157"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25128157, container: ".js-paper-rank-work_25128157", }); });</script></li><li class="js-percentile-work_25128157 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 25128157; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_25128157"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_25128157 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="25128157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 25128157; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=25128157]").text(description); $(".js-view-count-work_25128157").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_25128157").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="25128157"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="6791" rel="nofollow" href="https://www.academia.edu/Documents/in/Aging">Aging</a>, <script data-card-contents-for-ri="6791" type="text/json">{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12071" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>, <script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52438" rel="nofollow" href="https://www.academia.edu/Documents/in/Dogs">Dogs</a>, <script data-card-contents-for-ri="52438" type="text/json">{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25128157]'), work: {"id":25128157,"title":"Abnormal Neuronal Expression of the Calcium-binding Proteins, Parvalbumin and Calbindin D-28k, in Aged Dogs","created_at":"2016-05-08T06:04:01.950-07:00","url":"https://www.academia.edu/25128157/Abnormal_Neuronal_Expression_of_the_Calcium_binding_Proteins_Parvalbumin_and_Calbindin_D_28k_in_Aged_Dogs?f_ri=65615","dom_id":"work_25128157","summary":"Disturbances of the g-aminobutyric acid (GABA) neurotransmitter system have been implicated in chronic degenerative neurological disease. Cognitive dysfunction and neuron loss are features in older dogs. GABAergic neurons also show immunoreactivity for specific calcium-binding proteins. Immunohistochemistry was used to study the neuronal expression of calbindin D-28k and parvalbumin in different areas of the brain in 13 dogs, aged between 2 and 13Á5 years. Calbindin expression was found only in the cerebellum. There were significant differences in the quantity and distribution of neurons expressing these proteins between geriatric and adult brains. Parvalbumin-and calbindin-expressing neurons are relatively sensitive to degeneration in the cerebellum of older dogs. Parvalbumin labelling was associated with dystrophic structures that are commonly associated with ageing.","downloadable_attachments":[{"id":45448826,"asset_id":25128157,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":48404443,"first_name":"Enric","last_name":"Vidal","domain_name":"independent","page_name":"VidalEnric","display_name":"Enric Vidal","profile_url":"https://independent.academia.edu/VidalEnric?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=65615","nofollow":true},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=65615","nofollow":true},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615"},{"id":436755,"name":"Degeneration","url":"https://www.academia.edu/Documents/in/Degeneration?f_ri=65615"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences?f_ri=65615"},{"id":1010730,"name":"Calcium Binding Protein","url":"https://www.academia.edu/Documents/in/Calcium_Binding_Protein?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16519853" data-work_id="16519853" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16519853/Pharmacological_heterogeneity_of_NMDA_receptors_in_cerebellar_granule_cells_in_immature_rat_slices_A_microfluorimetric_study_with_the_Ca2_i_sensitive_dye_indo_1">Pharmacological heterogeneity of NMDA receptors in cerebellar granule cells in immature rat slices. A microfluorimetric study with the [Ca2+]i sensitive dye indo-1</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We have developed a technique for monitoring the internal calcium concentration-[Ca2+li-in a single selected cell in cerebellar slices of &day-old rats. In post-migratory granule cells NMDA induced a rapid, reversible and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16519853" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We have developed a technique for monitoring the internal calcium concentration-[Ca2+li-in a single selected cell in cerebellar slices of &day-old rats. In post-migratory granule cells NMDA induced a rapid, reversible and concentration-dependent increase in [Ca2+li ( + 22% at 10 /*M and + 210% at 100 PM). This effect was dependent on the presence of Ca2+ in the extracellular medium. When Mg'+ was absent from the perfusion buffer the sensitivity to NMDA was greatly increased (+ 108% at 10 PM). The NMDA response was not affected by glycine site agonists or by tetrodotoxin, a sodium channel blocker.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16519853" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b93f9867062d7961f4454ad7f811d660" rel="nofollow" data-download="{"attachment_id":42449690,"asset_id":16519853,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42449690/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35767955" href="https://u-psud.academia.edu/Jes%C3%B9sBenavides">Jesùs Benavides</a><script data-card-contents-for-user="35767955" type="text/json">{"id":35767955,"first_name":"Jesùs","last_name":"Benavides","domain_name":"u-psud","page_name":"JesùsBenavides","display_name":"Jesùs Benavides","profile_url":"https://u-psud.academia.edu/Jes%C3%B9sBenavides?f_ri=65615","photo":"https://0.academia-photos.com/35767955/10355485/11555784/s65_jes_s.benavides.jpg"}</script></span></span></li><li class="js-paper-rank-work_16519853 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16519853"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16519853, container: ".js-paper-rank-work_16519853", }); 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$(".js-view-count[data-work-id=16519853]").text(description); $(".js-view-count-work_16519853").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16519853").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16519853"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7955" rel="nofollow" href="https://www.academia.edu/Documents/in/Neuropharmacology">Neuropharmacology</a>, <script data-card-contents-for-ri="7955" type="text/json">{"id":7955,"name":"Neuropharmacology","url":"https://www.academia.edu/Documents/in/Neuropharmacology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9534" rel="nofollow" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46034" rel="nofollow" href="https://www.academia.edu/Documents/in/Polyamines">Polyamines</a><script data-card-contents-for-ri="46034" type="text/json">{"id":46034,"name":"Polyamines","url":"https://www.academia.edu/Documents/in/Polyamines?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16519853]'), work: {"id":16519853,"title":"Pharmacological heterogeneity of NMDA receptors in cerebellar granule cells in immature rat slices. A microfluorimetric study with the [Ca2+]i sensitive dye indo-1","created_at":"2015-10-06T13:26:28.594-07:00","url":"https://www.academia.edu/16519853/Pharmacological_heterogeneity_of_NMDA_receptors_in_cerebellar_granule_cells_in_immature_rat_slices_A_microfluorimetric_study_with_the_Ca2_i_sensitive_dye_indo_1?f_ri=65615","dom_id":"work_16519853","summary":"We have developed a technique for monitoring the internal calcium concentration-[Ca2+li-in a single selected cell in cerebellar slices of \u0026day-old rats. In post-migratory granule cells NMDA induced a rapid, reversible and concentration-dependent increase in [Ca2+li ( + 22% at 10 /*M and + 210% at 100 PM). This effect was dependent on the presence of Ca2+ in the extracellular medium. When Mg'+ was absent from the perfusion buffer the sensitivity to NMDA was greatly increased (+ 108% at 10 PM). The NMDA response was not affected by glycine site agonists or by tetrodotoxin, a sodium channel blocker.","downloadable_attachments":[{"id":42449690,"asset_id":16519853,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35767955,"first_name":"Jesùs","last_name":"Benavides","domain_name":"u-psud","page_name":"JesùsBenavides","display_name":"Jesùs Benavides","profile_url":"https://u-psud.academia.edu/Jes%C3%B9sBenavides?f_ri=65615","photo":"https://0.academia-photos.com/35767955/10355485/11555784/s65_jes_s.benavides.jpg"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=65615","nofollow":true},{"id":7955,"name":"Neuropharmacology","url":"https://www.academia.edu/Documents/in/Neuropharmacology?f_ri=65615","nofollow":true},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=65615","nofollow":true},{"id":46034,"name":"Polyamines","url":"https://www.academia.edu/Documents/in/Polyamines?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":70902,"name":"Magnesium","url":"https://www.academia.edu/Documents/in/Magnesium?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":394778,"name":"Sodium channel","url":"https://www.academia.edu/Documents/in/Sodium_channel?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17145223" data-work_id="17145223" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17145223/Cerebellar_magnetic_stimulation_decreases_levodopa_induced_dyskinesias_in_Parkinson_disease">Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17145223" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the basal ganglia to the thalamus and the cortical motor areas. However, not only striatothalamocortical motor circuits but also other interconnected pathways could be implicated in its pathogenesis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17145223" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b737e8bbfcb8afc4055c0ea8e91f14c0" rel="nofollow" data-download="{"attachment_id":42306330,"asset_id":17145223,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42306330/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36590115" href="https://independent.academia.edu/elogerfo">emanuele lo gerfo</a><script data-card-contents-for-user="36590115" type="text/json">{"id":36590115,"first_name":"emanuele","last_name":"lo gerfo","domain_name":"independent","page_name":"elogerfo","display_name":"emanuele lo gerfo","profile_url":"https://independent.academia.edu/elogerfo?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17145223 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17145223"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17145223, container: ".js-paper-rank-work_17145223", }); });</script></li><li class="js-percentile-work_17145223 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 17145223; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_17145223"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_17145223 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="17145223"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 17145223; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=17145223]").text(description); $(".js-view-count-work_17145223").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17145223").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17145223"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="623" rel="nofollow" href="https://www.academia.edu/Documents/in/Neurology">Neurology</a>, <script data-card-contents-for-ri="623" type="text/json">{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6565" rel="nofollow" href="https://www.academia.edu/Documents/in/Transcranial_Magnetic_Stimulation">Transcranial Magnetic Stimulation</a>, <script data-card-contents-for-ri="6565" type="text/json">{"id":6565,"name":"Transcranial Magnetic Stimulation","url":"https://www.academia.edu/Documents/in/Transcranial_Magnetic_Stimulation?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17145223]'), work: {"id":17145223,"title":"Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease","created_at":"2015-10-22T01:28:13.056-07:00","url":"https://www.academia.edu/17145223/Cerebellar_magnetic_stimulation_decreases_levodopa_induced_dyskinesias_in_Parkinson_disease?f_ri=65615","dom_id":"work_17145223","summary":"The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the basal ganglia to the thalamus and the cortical motor areas. However, not only striatothalamocortical motor circuits but also other interconnected pathways could be implicated in its pathogenesis.","downloadable_attachments":[{"id":42306330,"asset_id":17145223,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36590115,"first_name":"emanuele","last_name":"lo gerfo","domain_name":"independent","page_name":"elogerfo","display_name":"emanuele lo gerfo","profile_url":"https://independent.academia.edu/elogerfo?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true},{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=65615","nofollow":true},{"id":6565,"name":"Transcranial Magnetic Stimulation","url":"https://www.academia.edu/Documents/in/Transcranial_Magnetic_Stimulation?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":66228,"name":"Thalamus","url":"https://www.academia.edu/Documents/in/Thalamus?f_ri=65615"},{"id":132020,"name":"Neuronal Plasticity","url":"https://www.academia.edu/Documents/in/Neuronal_Plasticity?f_ri=65615"},{"id":153836,"name":"Motor Cortex","url":"https://www.academia.edu/Documents/in/Motor_Cortex?f_ri=65615"},{"id":208014,"name":"Levodopa","url":"https://www.academia.edu/Documents/in/Levodopa?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":277705,"name":"Motor Evoked Potentials","url":"https://www.academia.edu/Documents/in/Motor_Evoked_Potentials?f_ri=65615"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=65615"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance?f_ri=65615"},{"id":704401,"name":"Neural pathways","url":"https://www.academia.edu/Documents/in/Neural_pathways?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26159748" data-work_id="26159748" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26159748/Reversible_and_non_reversible_enlargement_of_cerebrospinal_fluid_spaces_in_anorexia_nervosa">Reversible and non-reversible enlargement of cerebrospinal fluid spaces in anorexia nervosa</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Brain CT studies of 35 patients with anorexia nervosa confirmed the observations of other authors: cerebral dystrophic changes correlate with weight loss and the reversibility of these changes also correlates with the normalization of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_26159748" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Brain CT studies of 35 patients with anorexia nervosa confirmed the observations of other authors: cerebral dystrophic changes correlate with weight loss and the reversibility of these changes also correlates with the normalization of body weight. Other corroborated facts are: the most numerous and most pronounced enlargements are of the cortical sulci and the interhemispheric fissure, moderate widening affects the ventricles and the rarest and most insignificant changes are those of the cerebellum. The reversibility of the changes showed a parallel to the extent of the changes themselves and to the duration of improvement of the body weight. The reversibility of the enlargement of the cortical sulci and of the distances between the frontal horns of the lateral ventricles was more often significant than that of the abnormal measurements of the celia media. This difference is based on minimal early acquired brain damage which occurs in 60% of our patients. This high incidence of early acquired minimal brain disease in patients with anorexia nervosa is here discussed as a nonspecific predisposing factor. Although there is no exact explanation of the etiology of the reversible enlargement of cerebrospinal fluid (CSF) spaces in anorexia nervosa, the changes resemble those in alcoholics. The mechanisms of brain changes in alcoholism, as shown experimentally, seem to us to throw light on the probable mechanism of reversible dystrophic brain changes in anorexia nervosa.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26159748" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a39bc662643b9a157557c6ea81398b71" rel="nofollow" data-download="{"attachment_id":46488298,"asset_id":26159748,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46488298/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="916282" href="https://uni-koeln.academia.edu/RolandSchleiffer">Roland Schleiffer</a><script data-card-contents-for-user="916282" type="text/json">{"id":916282,"first_name":"Roland","last_name":"Schleiffer","domain_name":"uni-koeln","page_name":"RolandSchleiffer","display_name":"Roland Schleiffer","profile_url":"https://uni-koeln.academia.edu/RolandSchleiffer?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_26159748 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="26159748"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 26159748, container: ".js-paper-rank-work_26159748", }); 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$(".js-view-count[data-work-id=26159748]").text(description); $(".js-view-count-work_26159748").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_26159748").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="26159748"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1648" rel="nofollow" href="https://www.academia.edu/Documents/in/Computed_Tomography">Computed Tomography</a>, <script data-card-contents-for-ri="1648" type="text/json">{"id":1648,"name":"Computed Tomography","url":"https://www.academia.edu/Documents/in/Computed_Tomography?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="33242" rel="nofollow" href="https://www.academia.edu/Documents/in/Anorexia_Nervosa">Anorexia Nervosa</a>, <script data-card-contents-for-ri="33242" type="text/json">{"id":33242,"name":"Anorexia Nervosa","url":"https://www.academia.edu/Documents/in/Anorexia_Nervosa?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="60971" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebrospinal_Fluid">Cerebrospinal Fluid</a><script data-card-contents-for-ri="60971" type="text/json">{"id":60971,"name":"Cerebrospinal Fluid","url":"https://www.academia.edu/Documents/in/Cerebrospinal_Fluid?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=26159748]'), work: {"id":26159748,"title":"Reversible and non-reversible enlargement of cerebrospinal fluid spaces in anorexia nervosa","created_at":"2016-06-14T14:44:22.955-07:00","url":"https://www.academia.edu/26159748/Reversible_and_non_reversible_enlargement_of_cerebrospinal_fluid_spaces_in_anorexia_nervosa?f_ri=65615","dom_id":"work_26159748","summary":"Brain CT studies of 35 patients with anorexia nervosa confirmed the observations of other authors: cerebral dystrophic changes correlate with weight loss and the reversibility of these changes also correlates with the normalization of body weight. Other corroborated facts are: the most numerous and most pronounced enlargements are of the cortical sulci and the interhemispheric fissure, moderate widening affects the ventricles and the rarest and most insignificant changes are those of the cerebellum. The reversibility of the changes showed a parallel to the extent of the changes themselves and to the duration of improvement of the body weight. The reversibility of the enlargement of the cortical sulci and of the distances between the frontal horns of the lateral ventricles was more often significant than that of the abnormal measurements of the celia media. This difference is based on minimal early acquired brain damage which occurs in 60% of our patients. This high incidence of early acquired minimal brain disease in patients with anorexia nervosa is here discussed as a nonspecific predisposing factor. Although there is no exact explanation of the etiology of the reversible enlargement of cerebrospinal fluid (CSF) spaces in anorexia nervosa, the changes resemble those in alcoholics. The mechanisms of brain changes in alcoholism, as shown experimentally, seem to us to throw light on the probable mechanism of reversible dystrophic brain changes in anorexia nervosa.","downloadable_attachments":[{"id":46488298,"asset_id":26159748,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":916282,"first_name":"Roland","last_name":"Schleiffer","domain_name":"uni-koeln","page_name":"RolandSchleiffer","display_name":"Roland Schleiffer","profile_url":"https://uni-koeln.academia.edu/RolandSchleiffer?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1648,"name":"Computed Tomography","url":"https://www.academia.edu/Documents/in/Computed_Tomography?f_ri=65615","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true},{"id":33242,"name":"Anorexia Nervosa","url":"https://www.academia.edu/Documents/in/Anorexia_Nervosa?f_ri=65615","nofollow":true},{"id":60971,"name":"Cerebrospinal Fluid","url":"https://www.academia.edu/Documents/in/Cerebrospinal_Fluid?f_ri=65615","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex?f_ri=65615"},{"id":89805,"name":"Weight Loss","url":"https://www.academia.edu/Documents/in/Weight_Loss?f_ri=65615"},{"id":91500,"name":"Neuroradiology","url":"https://www.academia.edu/Documents/in/Neuroradiology?f_ri=65615"},{"id":100966,"name":"Brain Plasticity","url":"https://www.academia.edu/Documents/in/Brain_Plasticity?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight?f_ri=65615"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1431361,"name":"Brain Damage","url":"https://www.academia.edu/Documents/in/Brain_Damage?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13712079" data-work_id="13712079" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13712079/Frataxin_deficiency_increases_cyclooxygenase_2_and_prostaglandins_in_cell_and_animal_models_of_Friedreichs_ataxia">Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">An inherited deficiency of the mitochondrial protein frataxin causes Friedreich&#39;s ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear. Microarrays of neural tissue of animal models... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13712079" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">An inherited deficiency of the mitochondrial protein frataxin causes Friedreich&#39;s ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear. Microarrays of neural tissue of animal models of the disease showed decreases in antioxidant genes, and increases in inflammatory genes. Cyclooxygenase (COX)-derived oxylipins are important mediators of inflammation. We measured oxylipin levels using tandem mass spectrometry and ELISAs in multiple cell and animal models of FRDA. Mass spectrometry revealed increases in concentrations of prostaglandins, thromboxane B2, 15-HETE and 11-HETE in cerebellar samples of knockin knockout mice. One possible explanation for the elevated oxylipins is that frataxin deficiency results in increased COX activity. While constitutive COX1 was unchanged, inducible COX2 expression was elevated over 1.35-fold (P &lt; 0.05) in two Friedreich&#39;s mouse models and Friedreich&#39;s lymphocytes. Consistent with higher ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13712079" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2275e1fde5ed8d153c591be7a3676a40" rel="nofollow" data-download="{"attachment_id":45029475,"asset_id":13712079,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45029475/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32843052" href="https://ucdavis.academia.edu/JohnNewman">John Newman</a><script data-card-contents-for-user="32843052" type="text/json">{"id":32843052,"first_name":"John","last_name":"Newman","domain_name":"ucdavis","page_name":"JohnNewman","display_name":"John Newman","profile_url":"https://ucdavis.academia.edu/JohnNewman?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13712079 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13712079"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13712079, container: ".js-paper-rank-work_13712079", }); });</script></li><li class="js-percentile-work_13712079 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13712079; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13712079"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13712079 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13712079"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13712079; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13712079]").text(description); $(".js-view-count-work_13712079").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13712079").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13712079"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9334" rel="nofollow" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11298" rel="nofollow" href="https://www.academia.edu/Documents/in/Membrane_Proteins">Membrane Proteins</a>, <script data-card-contents-for-ri="11298" type="text/json">{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" rel="nofollow" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a>, <script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" rel="nofollow" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a><script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13712079]'), work: {"id":13712079,"title":"Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia","created_at":"2015-07-06T11:16:02.369-07:00","url":"https://www.academia.edu/13712079/Frataxin_deficiency_increases_cyclooxygenase_2_and_prostaglandins_in_cell_and_animal_models_of_Friedreichs_ataxia?f_ri=65615","dom_id":"work_13712079","summary":"An inherited deficiency of the mitochondrial protein frataxin causes Friedreich\u0026#39;s ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear. Microarrays of neural tissue of animal models of the disease showed decreases in antioxidant genes, and increases in inflammatory genes. Cyclooxygenase (COX)-derived oxylipins are important mediators of inflammation. We measured oxylipin levels using tandem mass spectrometry and ELISAs in multiple cell and animal models of FRDA. Mass spectrometry revealed increases in concentrations of prostaglandins, thromboxane B2, 15-HETE and 11-HETE in cerebellar samples of knockin knockout mice. One possible explanation for the elevated oxylipins is that frataxin deficiency results in increased COX activity. While constitutive COX1 was unchanged, inducible COX2 expression was elevated over 1.35-fold (P \u0026lt; 0.05) in two Friedreich\u0026#39;s mouse models and Friedreich\u0026#39;s lymphocytes. Consistent with higher ...","downloadable_attachments":[{"id":45029475,"asset_id":13712079,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32843052,"first_name":"John","last_name":"Newman","domain_name":"ucdavis","page_name":"JohnNewman","display_name":"John Newman","profile_url":"https://ucdavis.academia.edu/JohnNewman?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=65615","nofollow":true},{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins?f_ri=65615","nofollow":true},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=65615","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=65615","nofollow":true},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=65615"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=65615"},{"id":116160,"name":"Human Molecular Genetics","url":"https://www.academia.edu/Documents/in/Human_Molecular_Genetics?f_ri=65615"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes?f_ri=65615"},{"id":708670,"name":"Prostaglandins","url":"https://www.academia.edu/Documents/in/Prostaglandins?f_ri=65615"},{"id":1684692,"name":"Friedreich Ataxia","url":"https://www.academia.edu/Documents/in/Friedreich_Ataxia?f_ri=65615"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation?f_ri=65615"},{"id":1876570,"name":"Iron binding proteins","url":"https://www.academia.edu/Documents/in/Iron_binding_proteins?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17024814" data-work_id="17024814" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17024814/Infratentorial_ependymomas_prognostic_factors_and_outcome_analysis_in_a_multi_center_retrospective_series_of_106_adult_patients">Infratentorial ependymomas: prognostic factors and outcome analysis in a multi-center retrospective series of 106 adult patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Object This study was undertaken to analyze outcomes and to assess the prognostic impact of age, location, surgery, radiotherapy (RT), and histopathology in a series of adult infratentorial ependymomas. Methods This was a retrospective... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17024814" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Object This study was undertaken to analyze outcomes and to assess the prognostic impact of age, location, surgery, radiotherapy (RT), and histopathology in a series of adult infratentorial ependymomas. Methods This was a retrospective study of a population of 106 adult patients with infratentorial ependymomas diagnosed between 1990 and 2004. A central pathological review of all cases was performed. Grading was according to the WHO and Marseille's neograding classifications. Results The series consisted of 58 males (54.7%) and 48 females (45.3%) in the age range of 18-82 years. Using the WHO classification, 88 patients (83.0%) had grade II and 18 patients (17.0%) grade III ependymomas. Using the Marseille's neograding system, 91 patients were low-grade and 15 high-grade. Gross total resection was achieved in 66 patients (62.3%). Thirty-seven patients (35.0%) received adjuvant RT. The 5-and 10-year overall survival rates for the entire cohort were 86.1% and 80.5%, respectively. On multivariate analysis, a preoperative Karnofski performance status score>80, no recessus lateral extension and a low histological grade (Marseille's grading) were associated with a longer overall survival. The 5-and 10-year progression-free survival rates for the entire cohort were 70.8% and 57.7%, respectively. On multivariate analysis, no recessus lateral extension, gross total resection and a low Acta Neurochir (2009) 151:947-960 histological grade (Marseille's grading) were associated with a longer progression-free survival. Adjuvant RT was significantly associated with a better overall and progression-free survival in incompletely resected WHO grade II ependymomas. Conclusions This study highlights the key role of histology in the clinical outcome and the fact that gross total resection is a main prognostic factor and the treatment of choice for posterior fossa ependymomas. The use of adjuvant RT in patients with incompletely resected WHO grade II ependymomas appears beneficial, but its effect on high-grade tumors remains to be determined.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17024814" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e39bec53fa29a84b76240aa825d99f48" rel="nofollow" data-download="{"attachment_id":42354798,"asset_id":17024814,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42354798/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36575547" href="https://independent.academia.edu/JacquesGuyotat">Jacques Guyotat</a><script data-card-contents-for-user="36575547" type="text/json">{"id":36575547,"first_name":"Jacques","last_name":"Guyotat","domain_name":"independent","page_name":"JacquesGuyotat","display_name":"Jacques Guyotat","profile_url":"https://independent.academia.edu/JacquesGuyotat?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17024814 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17024814"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17024814, container: ".js-paper-rank-work_17024814", }); 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$(".js-view-count[data-work-id=17024814]").text(description); $(".js-view-count-work_17024814").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17024814").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17024814"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="133057" rel="nofollow" href="https://www.academia.edu/Documents/in/Young_Adult">Young Adult</a><script data-card-contents-for-ri="133057" type="text/json">{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17024814]'), work: {"id":17024814,"title":"Infratentorial ependymomas: prognostic factors and outcome analysis in a multi-center retrospective series of 106 adult patients","created_at":"2015-10-19T23:16:13.724-07:00","url":"https://www.academia.edu/17024814/Infratentorial_ependymomas_prognostic_factors_and_outcome_analysis_in_a_multi_center_retrospective_series_of_106_adult_patients?f_ri=65615","dom_id":"work_17024814","summary":"Object This study was undertaken to analyze outcomes and to assess the prognostic impact of age, location, surgery, radiotherapy (RT), and histopathology in a series of adult infratentorial ependymomas. Methods This was a retrospective study of a population of 106 adult patients with infratentorial ependymomas diagnosed between 1990 and 2004. A central pathological review of all cases was performed. Grading was according to the WHO and Marseille's neograding classifications. Results The series consisted of 58 males (54.7%) and 48 females (45.3%) in the age range of 18-82 years. Using the WHO classification, 88 patients (83.0%) had grade II and 18 patients (17.0%) grade III ependymomas. Using the Marseille's neograding system, 91 patients were low-grade and 15 high-grade. Gross total resection was achieved in 66 patients (62.3%). Thirty-seven patients (35.0%) received adjuvant RT. The 5-and 10-year overall survival rates for the entire cohort were 86.1% and 80.5%, respectively. On multivariate analysis, a preoperative Karnofski performance status score\u003e80, no recessus lateral extension and a low histological grade (Marseille's grading) were associated with a longer overall survival. The 5-and 10-year progression-free survival rates for the entire cohort were 70.8% and 57.7%, respectively. On multivariate analysis, no recessus lateral extension, gross total resection and a low Acta Neurochir (2009) 151:947-960 histological grade (Marseille's grading) were associated with a longer progression-free survival. Adjuvant RT was significantly associated with a better overall and progression-free survival in incompletely resected WHO grade II ependymomas. Conclusions This study highlights the key role of histology in the clinical outcome and the fact that gross total resection is a main prognostic factor and the treatment of choice for posterior fossa ependymomas. The use of adjuvant RT in patients with incompletely resected WHO grade II ependymomas appears beneficial, but its effect on high-grade tumors remains to be determined.","downloadable_attachments":[{"id":42354798,"asset_id":17024814,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36575547,"first_name":"Jacques","last_name":"Guyotat","domain_name":"independent","page_name":"JacquesGuyotat","display_name":"Jacques Guyotat","profile_url":"https://independent.academia.edu/JacquesGuyotat?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=65615","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=65615","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=65615"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=65615"},{"id":426463,"name":"ACTA","url":"https://www.academia.edu/Documents/in/ACTA?f_ri=65615"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=65615"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=65615"},{"id":990198,"name":"Retrospective Study","url":"https://www.academia.edu/Documents/in/Retrospective_Study?f_ri=65615"},{"id":1225372,"name":"Overall Survival","url":"https://www.academia.edu/Documents/in/Overall_Survival?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75301230" data-work_id="75301230" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75301230/The_Involvement_of_p53_in_Dopamine_Induced_Apoptosis_of_Cerebellar_Granule_Neurons_and_Leukemic_Cells_Overexpressing_p53">The Involvement of p53 in Dopamine-Induced Apoptosis of Cerebellar Granule Neurons and Leukemic Cells Overexpressing p53</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">1. The pathogenesis of the selective degeneration of the dopaminergic neurons in Parkinson's disease is still enigmatic. Recently we have shown that dopamine can induce apoptosis in postmitotic neuronal cells, as well as in other cellular... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_75301230" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">1. The pathogenesis of the selective degeneration of the dopaminergic neurons in Parkinson's disease is still enigmatic. Recently we have shown that dopamine can induce apoptosis in postmitotic neuronal cells, as well as in other cellular systems, thus suggesting a role for this endogenous neurotransmitter and associated oxidative stress in the neuronal death process. 2. Dopamine has been shown to be capable of inducing DNA damage through its oxidative metabolites. p53 is a transcription factor that has a major role in determining cell fate in response to DNA damage. We therefore examined the possible correlation between dopamine-triggered apoptosis, DNA damage and levels of total phosphorylated p53 protein in cultured mouse cerebellar granule neurons. 3. Marked DNA damage and apoptotic nuclear condensation and fragmentation were detected within several hours of exposure to dopamine. An associated marked threefold increase in p53 phosphorylation was observed within this time window. Using a temperature-sensitive p53 activation system in leukemia LTR6 cells, were found that p53 inactivation dramatically attenuated dopamine toxicity. 4. We therefore conclude that DNA damage and p53 activation may have a role in mediating dopamine-induced apoptosis. Modulation of the p53 system may therefore have a protective role against the toxicity of this endogenous neurotransmitter and associated oxidative stress.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75301230" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c55d577180fba26f14b9e7ab3057c4ea" rel="nofollow" data-download="{"attachment_id":83124636,"asset_id":75301230,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83124636/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33522103" href="https://independent.academia.edu/AriBarzilai">Ari Barzilai</a><script data-card-contents-for-user="33522103" type="text/json">{"id":33522103,"first_name":"Ari","last_name":"Barzilai","domain_name":"independent","page_name":"AriBarzilai","display_name":"Ari Barzilai","profile_url":"https://independent.academia.edu/AriBarzilai?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_75301230 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="75301230"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 75301230, container: ".js-paper-rank-work_75301230", }); });</script></li><li class="js-percentile-work_75301230 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75301230; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_75301230"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_75301230 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="75301230"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75301230; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75301230]").text(description); $(".js-view-count-work_75301230").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_75301230").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="75301230"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4987" rel="nofollow" href="https://www.academia.edu/Documents/in/Kinetics">Kinetics</a>, <script data-card-contents-for-ri="4987" type="text/json">{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" rel="nofollow" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23066" rel="nofollow" href="https://www.academia.edu/Documents/in/DNA_damage">DNA damage</a>, <script data-card-contents-for-ri="23066" type="text/json">{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" rel="nofollow" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a><script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75301230]'), work: {"id":75301230,"title":"The Involvement of p53 in Dopamine-Induced Apoptosis of Cerebellar Granule Neurons and Leukemic Cells Overexpressing p53","created_at":"2022-04-03T03:38:17.482-07:00","url":"https://www.academia.edu/75301230/The_Involvement_of_p53_in_Dopamine_Induced_Apoptosis_of_Cerebellar_Granule_Neurons_and_Leukemic_Cells_Overexpressing_p53?f_ri=65615","dom_id":"work_75301230","summary":"1. The pathogenesis of the selective degeneration of the dopaminergic neurons in Parkinson's disease is still enigmatic. Recently we have shown that dopamine can induce apoptosis in postmitotic neuronal cells, as well as in other cellular systems, thus suggesting a role for this endogenous neurotransmitter and associated oxidative stress in the neuronal death process. 2. Dopamine has been shown to be capable of inducing DNA damage through its oxidative metabolites. p53 is a transcription factor that has a major role in determining cell fate in response to DNA damage. We therefore examined the possible correlation between dopamine-triggered apoptosis, DNA damage and levels of total phosphorylated p53 protein in cultured mouse cerebellar granule neurons. 3. Marked DNA damage and apoptotic nuclear condensation and fragmentation were detected within several hours of exposure to dopamine. An associated marked threefold increase in p53 phosphorylation was observed within this time window. Using a temperature-sensitive p53 activation system in leukemia LTR6 cells, were found that p53 inactivation dramatically attenuated dopamine toxicity. 4. We therefore conclude that DNA damage and p53 activation may have a role in mediating dopamine-induced apoptosis. Modulation of the p53 system may therefore have a protective role against the toxicity of this endogenous neurotransmitter and associated oxidative stress.","downloadable_attachments":[{"id":83124636,"asset_id":75301230,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33522103,"first_name":"Ari","last_name":"Barzilai","domain_name":"independent","page_name":"AriBarzilai","display_name":"Ari Barzilai","profile_url":"https://independent.academia.edu/AriBarzilai?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=65615","nofollow":true},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=65615","nofollow":true},{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage?f_ri=65615","nofollow":true},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=65615","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615"},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA?f_ri=65615"},{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=65615"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=65615"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615"},{"id":317801,"name":"Cell nucleus","url":"https://www.academia.edu/Documents/in/Cell_nucleus?f_ri=65615"},{"id":396278,"name":"Neuronal Death","url":"https://www.academia.edu/Documents/in/Neuronal_Death?f_ri=65615"},{"id":436755,"name":"Degeneration","url":"https://www.academia.edu/Documents/in/Degeneration?f_ri=65615"},{"id":1654784,"name":"Cerebellar Granule Neuron","url":"https://www.academia.edu/Documents/in/Cerebellar_Granule_Neuron?f_ri=65615"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=65615"},{"id":1714296,"name":"Cellular system","url":"https://www.academia.edu/Documents/in/Cellular_system?f_ri=65615"},{"id":2256666,"name":"DNA fragmentation","url":"https://www.academia.edu/Documents/in/DNA_fragmentation?f_ri=65615"},{"id":3276666,"name":"fluorescent dyes","url":"https://www.academia.edu/Documents/in/fluorescent_dyes?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_71335313" data-work_id="71335313" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/71335313/Monitoring_Performance_Degradation_of_Cerebellar_Functions_Using_Computational_Neuroscience_Methods_Implications_on_Neurological_Diseases">Monitoring Performance Degradation of Cerebellar Functions Using Computational Neuroscience Methods: Implications on Neurological Diseases</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Neurodegeneration is a major cause of human disease. Within the cerebellum, neuronal degeneration and/or dysfunction has been associated with many diseases, including several forms of cerebellar ataxia, since normal cerebellar function is... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_71335313" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Neurodegeneration is a major cause of human disease. Within the cerebellum, neuronal degeneration and/or dysfunction has been associated with many diseases, including several forms of cerebellar ataxia, since normal cerebellar function is paramount for proper motor coordination, balance, and motor learning. The cerebellum represents a well-established neural circuit. Determining the effects of neuronal loss is of great importance for understanding the fundamental workings of the cerebellum and disease-associated dysfunctions. This paper presents computational modeling of cerebellar function in relation to neurodegeneration either affecting a specific cerebellar cell type, such as granule cells or Purkinje cells, or more generally affecting cerebellar cells and the implications on effects in relation to performance degradation throughout the progression of cell death. The results of the models show that the overall number of cells, as a percentage of the total cell number in the mode...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/71335313" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="95250464" href="https://zixiutangpollencapsules.academia.edu/MajidShaalan">Majid Shaalan</a><script data-card-contents-for-user="95250464" type="text/json">{"id":95250464,"first_name":"Majid","last_name":"Shaalan","domain_name":"zixiutangpollencapsules","page_name":"MajidShaalan","display_name":"Majid Shaalan","profile_url":"https://zixiutangpollencapsules.academia.edu/MajidShaalan?f_ri=65615","photo":"https://0.academia-photos.com/95250464/30508822/28265530/s65_majid.shaalan.jpg"}</script></span></span></li><li class="js-paper-rank-work_71335313 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="71335313"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 71335313, container: ".js-paper-rank-work_71335313", }); 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Within the cerebellum, neuronal degeneration and/or dysfunction has been associated with many diseases, including several forms of cerebellar ataxia, since normal cerebellar function is paramount for proper motor coordination, balance, and motor learning. The cerebellum represents a well-established neural circuit. Determining the effects of neuronal loss is of great importance for understanding the fundamental workings of the cerebellum and disease-associated dysfunctions. This paper presents computational modeling of cerebellar function in relation to neurodegeneration either affecting a specific cerebellar cell type, such as granule cells or Purkinje cells, or more generally affecting cerebellar cells and the implications on effects in relation to performance degradation throughout the progression of cell death. The results of the models show that the overall number of cells, as a percentage of the total cell number in the mode...","downloadable_attachments":[],"ordered_authors":[{"id":95250464,"first_name":"Majid","last_name":"Shaalan","domain_name":"zixiutangpollencapsules","page_name":"MajidShaalan","display_name":"Majid Shaalan","profile_url":"https://zixiutangpollencapsules.academia.edu/MajidShaalan?f_ri=65615","photo":"https://0.academia-photos.com/95250464/30508822/28265530/s65_majid.shaalan.jpg"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=65615","nofollow":true},{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics?f_ri=65615","nofollow":true},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=65615","nofollow":true},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=65615","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=65615"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=65615"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615"},{"id":220780,"name":"PLoS one","url":"https://www.academia.edu/Documents/in/PLoS_one?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_60055246" data-work_id="60055246" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/60055246/The_coordination_of_posture_and_voluntary_movement_in_patients_with_cerebellar_dysfunction">The coordination of posture and voluntary movement in patients with cerebellar dysfunction</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Postural adjustments associated with the task of rising on tiptoes were investigated in a reaction time paradigm in 10 normal subjects and 18 patients with cerebellar disorders. Cerebellar dysfunction was due to either degenerative... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_60055246" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Postural adjustments associated with the task of rising on tiptoes were investigated in a reaction time paradigm in 10 normal subjects and 18 patients with cerebellar disorders. Cerebellar dysfunction was due to either degenerative cerebellar disease, tumor, or ischemia. Displacements of the center of foot pressure (CFP) were recorded. The task, accomplished by the triceps surae muscle (executional activity, mean latency of 41 1 ms), is mechan</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/60055246" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dbaad7484b618bb8f95f65cf0956c497" rel="nofollow" data-download="{"attachment_id":73667953,"asset_id":60055246,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73667953/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50623204" href="https://independent.academia.edu/TKlockgether">T. 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Cerebellar dysfunction was due to either degenerative cerebellar disease, tumor, or ischemia. Displacements of the center of foot pressure (CFP) were recorded. The task, accomplished by the triceps surae muscle (executional activity, mean latency of 41 1 ms), is mechan","downloadable_attachments":[{"id":73667953,"asset_id":60055246,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":50623204,"first_name":"T.","last_name":"Klockgether","domain_name":"independent","page_name":"TKlockgether","display_name":"T. 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Disorder","url":"https://www.academia.edu/Documents/in/Developmental_Coordination_Disorder?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64330528]'), work: {"id":64330528,"title":"Development and developmental disorders of the human cerebellum","created_at":"2021-12-15T09:26:54.145-08:00","url":"https://www.academia.edu/64330528/Development_and_developmental_disorders_of_the_human_cerebellum?f_ri=65615","dom_id":"work_64330528","summary":null,"downloadable_attachments":[{"id":76415007,"asset_id":64330528,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":66330350,"first_name":"Hans J.","last_name":"ten Donkelaar","domain_name":"independent","page_name":"HansJtenDonkelaar","display_name":"Hans J. ten Donkelaar","profile_url":"https://independent.academia.edu/HansJtenDonkelaar?f_ri=65615","photo":"https://0.academia-photos.com/66330350/18439079/18388317/s65_hans_j..ten_donkelaar.jpg"}],"research_interests":[{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=65615","nofollow":true},{"id":4116,"name":"Motor Learning","url":"https://www.academia.edu/Documents/in/Motor_Learning?f_ri=65615","nofollow":true},{"id":8735,"name":"Motor Control","url":"https://www.academia.edu/Documents/in/Motor_Control?f_ri=65615","nofollow":true},{"id":52253,"name":"Developmental Coordination Disorder","url":"https://www.academia.edu/Documents/in/Developmental_Coordination_Disorder?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":321836,"name":"Spectrum","url":"https://www.academia.edu/Documents/in/Spectrum?f_ri=65615"},{"id":647690,"name":"Inferior Olive","url":"https://www.academia.edu/Documents/in/Inferior_Olive?f_ri=65615"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1959400,"name":"Purkinje cell","url":"https://www.academia.edu/Documents/in/Purkinje_cell?f_ri=65615"},{"id":2226497,"name":"Deep cerebellar nuclei","url":"https://www.academia.edu/Documents/in/Deep_cerebellar_nuclei?f_ri=65615"},{"id":2706504,"name":"developmental Disorder","url":"https://www.academia.edu/Documents/in/developmental_Disorder?f_ri=65615"},{"id":2886477,"name":"Cerebellar Diseases","url":"https://www.academia.edu/Documents/in/Cerebellar_Diseases?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_60023959" data-work_id="60023959" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/60023959/Mutations_inCEP120cause_Joubert_syndrome_as_well_as_complex_ciliopathy_phenotypes">Mutations inCEP120cause Joubert syndrome as well as complex ciliopathy phenotypes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">BACKGROUND: Ciliopathies are an extensive group of autosomal recessive or X-linked disorders with considerable genetic and clinical overlap, which collectively share multiple organ involvement and may result in lethal or viable... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_60023959" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">BACKGROUND: Ciliopathies are an extensive group of autosomal recessive or X-linked disorders with considerable genetic and clinical overlap, which collectively share multiple organ involvement and may result in lethal or viable phenotypes. In large numbers of cases the genetic defect remains yet to be determined. The aim of this study is to describe the mutational frequency and phenotypic spectrum of the CEP120 gene. METHODS: Exome sequencing was performed in 145 patients with Joubert syndrome (JS), including 15 children with oral-facial-digital syndrome type VI (OFDVI) and 21 Meckel syndrome (MKS) fetuses. Moreover, exome sequencing was performed in one fetus with tectocerebellar dysraphia with occipital encephalocele (TCDOE), molar tooth sign and additional skeletal abnormalities. As a parallel study, 346 probands with a phenotype consistent with JS or related ciliopathies underwent nextgeneration sequencing-based targeted sequencing of 120 previously described and candidate ciliopathy genes. RESULTS: We present six probands carrying nine distinct mutations (of which eight are novel) in the CEP120 gene, previously found mutated only in Jeune asphyxiating thoracic dystrophy (JATD). The CEP120-associated phenotype ranges from mild classical JS in four patients to more severe conditions in two fetuses, with overlapping features of distinct ciliopathies that include TCDOE, MKS, JATD and OFD syndromes. No obvious correlation is evident between the type or location of identified mutations and the ciliopathy phenotype. CONCLUSION: Our findings broaden the spectrum of phenotypes caused by CEP120 mutations that account for nearly 1% of patients with JS as well as for more complex ciliopathy phenotypes. The lack of clear genotype-phenotype correlation highlights the relevance of comprehensive genetic analyses in the diagnostics of ciliopathies.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/60023959" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="af875d51d80cce4a857039369dc757aa" rel="nofollow" data-download="{"attachment_id":73652197,"asset_id":60023959,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73652197/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41575488" href="https://independent.academia.edu/JoachimVanKeirsbilck">Joachim Van Keirsbilck</a><script data-card-contents-for-user="41575488" type="text/json">{"id":41575488,"first_name":"Joachim Van","last_name":"Keirsbilck","domain_name":"independent","page_name":"JoachimVanKeirsbilck","display_name":"Joachim Van Keirsbilck","profile_url":"https://independent.academia.edu/JoachimVanKeirsbilck?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_60023959 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="60023959"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 60023959, container: ".js-paper-rank-work_60023959", }); 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$(".js-view-count[data-work-id=60023959]").text(description); $(".js-view-count-work_60023959").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_60023959").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="60023959"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2568" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Genetics">Medical Genetics</a>, <script data-card-contents-for-ri="2568" type="text/json">{"id":2568,"name":"Medical Genetics","url":"https://www.academia.edu/Documents/in/Medical_Genetics?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" rel="nofollow" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=60023959]'), work: {"id":60023959,"title":"Mutations inCEP120cause Joubert syndrome as well as complex ciliopathy phenotypes","created_at":"2021-10-26T03:57:17.462-07:00","url":"https://www.academia.edu/60023959/Mutations_inCEP120cause_Joubert_syndrome_as_well_as_complex_ciliopathy_phenotypes?f_ri=65615","dom_id":"work_60023959","summary":"BACKGROUND: Ciliopathies are an extensive group of autosomal recessive or X-linked disorders with considerable genetic and clinical overlap, which collectively share multiple organ involvement and may result in lethal or viable phenotypes. In large numbers of cases the genetic defect remains yet to be determined. The aim of this study is to describe the mutational frequency and phenotypic spectrum of the CEP120 gene. METHODS: Exome sequencing was performed in 145 patients with Joubert syndrome (JS), including 15 children with oral-facial-digital syndrome type VI (OFDVI) and 21 Meckel syndrome (MKS) fetuses. Moreover, exome sequencing was performed in one fetus with tectocerebellar dysraphia with occipital encephalocele (TCDOE), molar tooth sign and additional skeletal abnormalities. As a parallel study, 346 probands with a phenotype consistent with JS or related ciliopathies underwent nextgeneration sequencing-based targeted sequencing of 120 previously described and candidate ciliopathy genes. RESULTS: We present six probands carrying nine distinct mutations (of which eight are novel) in the CEP120 gene, previously found mutated only in Jeune asphyxiating thoracic dystrophy (JATD). The CEP120-associated phenotype ranges from mild classical JS in four patients to more severe conditions in two fetuses, with overlapping features of distinct ciliopathies that include TCDOE, MKS, JATD and OFD syndromes. No obvious correlation is evident between the type or location of identified mutations and the ciliopathy phenotype. CONCLUSION: Our findings broaden the spectrum of phenotypes caused by CEP120 mutations that account for nearly 1% of patients with JS as well as for more complex ciliopathy phenotypes. The lack of clear genotype-phenotype correlation highlights the relevance of comprehensive genetic analyses in the diagnostics of ciliopathies.","downloadable_attachments":[{"id":73652197,"asset_id":60023959,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":41575488,"first_name":"Joachim Van","last_name":"Keirsbilck","domain_name":"independent","page_name":"JoachimVanKeirsbilck","display_name":"Joachim Van Keirsbilck","profile_url":"https://independent.academia.edu/JoachimVanKeirsbilck?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2568,"name":"Medical Genetics","url":"https://www.academia.edu/Documents/in/Medical_Genetics?f_ri=65615","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=65615","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":73153,"name":"Genetic Testing","url":"https://www.academia.edu/Documents/in/Genetic_Testing?f_ri=65615"},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=65615"},{"id":95573,"name":"Ciliopathies","url":"https://www.academia.edu/Documents/in/Ciliopathies?f_ri=65615"},{"id":117200,"name":"Retina","url":"https://www.academia.edu/Documents/in/Retina?f_ri=65615"},{"id":125069,"name":"Genetic Association Studies","url":"https://www.academia.edu/Documents/in/Genetic_Association_Studies?f_ri=65615"},{"id":188349,"name":"Pedigree","url":"https://www.academia.edu/Documents/in/Pedigree?f_ri=65615"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype?f_ri=65615"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=65615"},{"id":983317,"name":"Cell Cycle Proteins","url":"https://www.academia.edu/Documents/in/Cell_Cycle_Proteins?f_ri=65615"},{"id":1243186,"name":"ENCEPHALOCELE","url":"https://www.academia.edu/Documents/in/ENCEPHALOCELE?f_ri=65615"},{"id":1264920,"name":"Mutation Rate","url":"https://www.academia.edu/Documents/in/Mutation_Rate?f_ri=65615"},{"id":2886477,"name":"Cerebellar Diseases","url":"https://www.academia.edu/Documents/in/Cerebellar_Diseases?f_ri=65615"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_59658060" data-work_id="59658060" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/59658060/Shape_Analysis_of_the_Corpus_Callosum_and_Cerebellum_in_Female_MS_Patients_with_Different_Clinical_Phenotypes">Shape Analysis of the Corpus Callosum and Cerebellum in Female MS Patients with Different Clinical Phenotypes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients compared with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_59658060" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients compared with healthy controls. This study was conducted using the magnetic resonance imaging scans of 15 control subjects, 26 RRMS, and 14 SPMS patients. The data obtained from the landmark coordinates were analyzed with statistical shape analysis. The landmarks that were chosen to determine the shape differences of the CC and cerebellum have been identified and used in previous studies. In addition to these landmarks, constructed landmarks were determined and used to assess regional shape differences better. The shapes of the CC and cerebellum showed statistically significant differences from the controls when compared with both the RRMS and SPMS patients. It was found that the deformation observed from controls to SPMS was greater than the deformation from controls to RRMS, both for the CC and cerebellum. In conclusion, this study revealed CC and cerebellar shape change in RRMS and SPMS, and showed that deformations both in CC and cerebellum advances with the disease progression.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/59658060" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5a5b73d3557e9f919b6d445fbf3a80cd" rel="nofollow" data-download="{"attachment_id":73468073,"asset_id":59658060,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73468073/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="67024800" href="https://independent.academia.edu/OTaskapilioglu">Ozlem Taskapilioglu</a><script data-card-contents-for-user="67024800" type="text/json">{"id":67024800,"first_name":"Ozlem","last_name":"Taskapilioglu","domain_name":"independent","page_name":"OTaskapilioglu","display_name":"Ozlem Taskapilioglu","profile_url":"https://independent.academia.edu/OTaskapilioglu?f_ri=65615","photo":"https://gravatar.com/avatar/4628823b27f404f825cb9421118c648d?s=65"}</script></span></span></li><li class="js-paper-rank-work_59658060 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="59658060"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 59658060, container: ".js-paper-rank-work_59658060", }); });</script></li><li class="js-percentile-work_59658060 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 59658060; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_59658060"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_59658060 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="59658060"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 59658060; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=59658060]").text(description); $(".js-view-count-work_59658060").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_59658060").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="59658060"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="6200" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging">Magnetic Resonance Imaging</a>, <script data-card-contents-for-ri="6200" type="text/json">{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" rel="nofollow" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a>, <script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65614" rel="nofollow" href="https://www.academia.edu/Documents/in/Corpus_Callosum">Corpus Callosum</a>, <script data-card-contents-for-ri="65614" type="text/json">{"id":65614,"name":"Corpus Callosum","url":"https://www.academia.edu/Documents/in/Corpus_Callosum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=59658060]'), work: {"id":59658060,"title":"Shape Analysis of the Corpus Callosum and Cerebellum in Female MS Patients with Different Clinical Phenotypes","created_at":"2021-10-23T07:29:36.029-07:00","url":"https://www.academia.edu/59658060/Shape_Analysis_of_the_Corpus_Callosum_and_Cerebellum_in_Female_MS_Patients_with_Different_Clinical_Phenotypes?f_ri=65615","dom_id":"work_59658060","summary":"The aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients compared with healthy controls. This study was conducted using the magnetic resonance imaging scans of 15 control subjects, 26 RRMS, and 14 SPMS patients. The data obtained from the landmark coordinates were analyzed with statistical shape analysis. The landmarks that were chosen to determine the shape differences of the CC and cerebellum have been identified and used in previous studies. In addition to these landmarks, constructed landmarks were determined and used to assess regional shape differences better. The shapes of the CC and cerebellum showed statistically significant differences from the controls when compared with both the RRMS and SPMS patients. It was found that the deformation observed from controls to SPMS was greater than the deformation from controls to RRMS, both for the CC and cerebellum. In conclusion, this study revealed CC and cerebellar shape change in RRMS and SPMS, and showed that deformations both in CC and cerebellum advances with the disease progression.","downloadable_attachments":[{"id":73468073,"asset_id":59658060,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":67024800,"first_name":"Ozlem","last_name":"Taskapilioglu","domain_name":"independent","page_name":"OTaskapilioglu","display_name":"Ozlem Taskapilioglu","profile_url":"https://independent.academia.edu/OTaskapilioglu?f_ri=65615","photo":"https://gravatar.com/avatar/4628823b27f404f825cb9421118c648d?s=65"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=65615","nofollow":true},{"id":65614,"name":"Corpus Callosum","url":"https://www.academia.edu/Documents/in/Corpus_Callosum?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=65615"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype?f_ri=65615"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=65615"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=65615"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4678824 coauthored" data-work_id="4678824" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4678824/Cerebellar_induced_aphasia_case_report_of_cerebellar_induced_prefrontal_aphasic_language_phenomena_supported_by_SPECT_findings">Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4678824" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f4d836a46ad56457981baf75269f1208" rel="nofollow" data-download="{"attachment_id":49700581,"asset_id":4678824,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49700581/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5944360" href="https://vub.academia.edu/PeterMari%C3%ABn">Peter Mariën</a><script data-card-contents-for-user="5944360" type="text/json">{"id":5944360,"first_name":"Peter","last_name":"Mariën","domain_name":"vub","page_name":"PeterMariën","display_name":"Peter Mariën","profile_url":"https://vub.academia.edu/PeterMari%C3%ABn?f_ri=65615","photo":"https://0.academia-photos.com/5944360/2527512/2934019/s65_peter.mari_n.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-4678824">+1</span><div class="hidden js-additional-users-4678824"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/RDierckx">R. Dierckx</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-4678824'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-4678824').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_4678824 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4678824"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4678824, container: ".js-paper-rank-work_4678824", }); });</script></li><li class="js-percentile-work_4678824 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 4678824; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_4678824"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_4678824 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="4678824"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4678824; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=4678824]").text(description); $(".js-view-count-work_4678824").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_4678824").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="4678824"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="5738" rel="nofollow" href="https://www.academia.edu/Documents/in/Aphasia">Aphasia</a>, <script data-card-contents-for-ri="5738" type="text/json">{"id":5738,"name":"Aphasia","url":"https://www.academia.edu/Documents/in/Aphasia?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="28576" rel="nofollow" href="https://www.academia.edu/Documents/in/Prefrontal_Cortex">Prefrontal Cortex</a>, <script data-card-contents-for-ri="28576" type="text/json">{"id":28576,"name":"Prefrontal Cortex","url":"https://www.academia.edu/Documents/in/Prefrontal_Cortex?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="63886" rel="nofollow" href="https://www.academia.edu/Documents/in/Case_Report">Case Report</a>, <script data-card-contents-for-ri="63886" type="text/json">{"id":63886,"name":"Case Report","url":"https://www.academia.edu/Documents/in/Case_Report?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a><script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=4678824]'), work: {"id":4678824,"title":"Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings","created_at":"2013-10-04T16:44:04.983-07:00","url":"https://www.academia.edu/4678824/Cerebellar_induced_aphasia_case_report_of_cerebellar_induced_prefrontal_aphasic_language_phenomena_supported_by_SPECT_findings?f_ri=65615","dom_id":"work_4678824","summary":null,"downloadable_attachments":[{"id":49700581,"asset_id":4678824,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5944360,"first_name":"Peter","last_name":"Mariën","domain_name":"vub","page_name":"PeterMariën","display_name":"Peter Mariën","profile_url":"https://vub.academia.edu/PeterMari%C3%ABn?f_ri=65615","photo":"https://0.academia-photos.com/5944360/2527512/2934019/s65_peter.mari_n.jpg"},{"id":40636191,"first_name":"R.","last_name":"Dierckx","domain_name":"independent","page_name":"RDierckx","display_name":"R. Dierckx","profile_url":"https://independent.academia.edu/RDierckx?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":5738,"name":"Aphasia","url":"https://www.academia.edu/Documents/in/Aphasia?f_ri=65615","nofollow":true},{"id":28576,"name":"Prefrontal Cortex","url":"https://www.academia.edu/Documents/in/Prefrontal_Cortex?f_ri=65615","nofollow":true},{"id":63886,"name":"Case Report","url":"https://www.academia.edu/Documents/in/Case_Report?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":123404,"name":"Verbal behavior","url":"https://www.academia.edu/Documents/in/Verbal_behavior?f_ri=65615"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=65615"},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The?f_ri=65615"},{"id":172827,"name":"Brain Ischemia","url":"https://www.academia.edu/Documents/in/Brain_Ischemia?f_ri=65615"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=65615"},{"id":375439,"name":"Single Photon Emission Computed Tomography","url":"https://www.academia.edu/Documents/in/Single_Photon_Emission_Computed_Tomography?f_ri=65615"},{"id":810789,"name":"Left Hemisphere","url":"https://www.academia.edu/Documents/in/Left_Hemisphere?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1274453,"name":"Right Handed","url":"https://www.academia.edu/Documents/in/Right_Handed?f_ri=65615"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12157948" data-work_id="12157948" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12157948/Separation_of_cannabinoid_receptor_affinity_and_efficacy_in_delta_8_tetrahydrocannabinol_side_chain_analogues">Separation of cannabinoid receptor affinity and efficacy in delta-8-tetrahydrocannabinol side-chain analogues</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The activities of a number of side-chain analogues of delta-8-tetrahydrocannabinol (Δ8-THC) in rat cerebellar membrane preparations were tested.The affinities of each compound for the CB1 receptor were compared by their respective... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12157948" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The activities of a number of side-chain analogues of delta-8-tetrahydrocannabinol (Δ8-THC) in rat cerebellar membrane preparations were tested.The affinities of each compound for the CB1 receptor were compared by their respective abilities to displace [3H]-SR141716A and their efficacies compared by stimulation of [35S]-GTPγS binding.It was found that the affinities varied from 0.19±0.03 nM for 3-norpentyl-3-[6′-cyano,1′,1′-dimethyl]hexyl-Δ8-THC to 395±66.3 nM for 5′-[N-(4-chlorophenyl)]-1′,1′-dimethyl-carboxamido-Δ8-THC.The efficacies of these compounds varied greatly, ranging from the very low efficacy exhibited to acetylenic compounds such as 1′-heptyn-Δ8-THC and 4′-octyn-Δ8-THC to higher efficacy compounds such as 5′-(4-cyanophenoxy)-1′,1′-dimethyl-Δ8-THC and 5′-[N-(4-aminosulphonylphenyl)]-1′,1′ dimethyl-carboxamido Δ8-THC. All agonist activities were antagonized by the CB1-selective antagonist SR141716A.It was found that a ligand's CB1 affinity and efficacy are differentially altered by modifications in the side-chain. Decreasing the flexibility of the side-chain reduced efficacy but largely did not alter affinity. Additionally, the positioning of electrostatic moieties, such as cyano groups, within the side-chain also has contrasting effects on these two properties.In summary, this report details the characterization of a number of novel Δ8-THC analogues in rat cerebellar membranes. It provides the first detailed pharmacological analysis of how the inclusion of electrostatic moieties in the side-chain and also how alteration of the side-chain's flexibility may differentially affect a CB1 cannabinoid receptor ligand's affinity and efficacy.The activities of a number of side-chain analogues of delta-8-tetrahydrocannabinol (Δ8-THC) in rat cerebellar membrane preparations were tested.The affinities of each compound for the CB1 receptor were compared by their respective abilities to displace [3H]-SR141716A and their efficacies compared by stimulation of [35S]-GTPγS binding.It was found that the affinities varied from 0.19±0.03 nM for 3-norpentyl-3-[6′-cyano,1′,1′-dimethyl]hexyl-Δ8-THC to 395±66.3 nM for 5′-[N-(4-chlorophenyl)]-1′,1′-dimethyl-carboxamido-Δ8-THC.The efficacies of these compounds varied greatly, ranging from the very low efficacy exhibited to acetylenic compounds such as 1′-heptyn-Δ8-THC and 4′-octyn-Δ8-THC to higher efficacy compounds such as 5′-(4-cyanophenoxy)-1′,1′-dimethyl-Δ8-THC and 5′-[N-(4-aminosulphonylphenyl)]-1′,1′ dimethyl-carboxamido Δ8-THC. All agonist activities were antagonized by the CB1-selective antagonist SR141716A.It was found that a ligand's CB1 affinity and efficacy are differentially altered by modifications in the side-chain. Decreasing the flexibility of the side-chain reduced efficacy but largely did not alter affinity. Additionally, the positioning of electrostatic moieties, such as cyano groups, within the side-chain also has contrasting effects on these two properties.In summary, this report details the characterization of a number of novel Δ8-THC analogues in rat cerebellar membranes. It provides the first detailed pharmacological analysis of how the inclusion of electrostatic moieties in the side-chain and also how alteration of the side-chain's flexibility may differentially affect a CB1 cannabinoid receptor ligand's affinity and efficacy.British Journal of Pharmacology (2001) 132, 525–535; doi:10.1038/sj.bjp.0703827</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12157948" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b97ada8715c50744d330319295048e61" rel="nofollow" data-download="{"attachment_id":46328529,"asset_id":12157948,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46328529/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="30524353" href="https://independent.academia.edu/AungMieMie">Mie Mie Aung</a><script data-card-contents-for-user="30524353" type="text/json">{"id":30524353,"first_name":"Mie Mie","last_name":"Aung","domain_name":"independent","page_name":"AungMieMie","display_name":"Mie Mie Aung","profile_url":"https://independent.academia.edu/AungMieMie?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12157948 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12157948"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12157948, container: ".js-paper-rank-work_12157948", }); 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$(".js-view-count[data-work-id=12157948]").text(description); $(".js-view-count-work_12157948").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12157948").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12157948"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7324" rel="nofollow" href="https://www.academia.edu/Documents/in/British">British</a>, <script data-card-contents-for-ri="7324" type="text/json">{"id":7324,"name":"British","url":"https://www.academia.edu/Documents/in/British?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="375054" rel="nofollow" href="https://www.academia.edu/Documents/in/Rats">Rats</a>, <script data-card-contents-for-ri="375054" type="text/json">{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="432361" rel="nofollow" href="https://www.academia.edu/Documents/in/Radioligand_Assay">Radioligand Assay</a><script data-card-contents-for-ri="432361" type="text/json">{"id":432361,"name":"Radioligand Assay","url":"https://www.academia.edu/Documents/in/Radioligand_Assay?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12157948]'), work: {"id":12157948,"title":"Separation of cannabinoid receptor affinity and efficacy in delta-8-tetrahydrocannabinol side-chain analogues","created_at":"2015-04-29T15:04:26.661-07:00","url":"https://www.academia.edu/12157948/Separation_of_cannabinoid_receptor_affinity_and_efficacy_in_delta_8_tetrahydrocannabinol_side_chain_analogues?f_ri=65615","dom_id":"work_12157948","summary":"The activities of a number of side-chain analogues of delta-8-tetrahydrocannabinol (Δ8-THC) in rat cerebellar membrane preparations were tested.The affinities of each compound for the CB1 receptor were compared by their respective abilities to displace [3H]-SR141716A and their efficacies compared by stimulation of [35S]-GTPγS binding.It was found that the affinities varied from 0.19±0.03 nM for 3-norpentyl-3-[6′-cyano,1′,1′-dimethyl]hexyl-Δ8-THC to 395±66.3 nM for 5′-[N-(4-chlorophenyl)]-1′,1′-dimethyl-carboxamido-Δ8-THC.The efficacies of these compounds varied greatly, ranging from the very low efficacy exhibited to acetylenic compounds such as 1′-heptyn-Δ8-THC and 4′-octyn-Δ8-THC to higher efficacy compounds such as 5′-(4-cyanophenoxy)-1′,1′-dimethyl-Δ8-THC and 5′-[N-(4-aminosulphonylphenyl)]-1′,1′ dimethyl-carboxamido Δ8-THC. All agonist activities were antagonized by the CB1-selective antagonist SR141716A.It was found that a ligand's CB1 affinity and efficacy are differentially altered by modifications in the side-chain. Decreasing the flexibility of the side-chain reduced efficacy but largely did not alter affinity. Additionally, the positioning of electrostatic moieties, such as cyano groups, within the side-chain also has contrasting effects on these two properties.In summary, this report details the characterization of a number of novel Δ8-THC analogues in rat cerebellar membranes. It provides the first detailed pharmacological analysis of how the inclusion of electrostatic moieties in the side-chain and also how alteration of the side-chain's flexibility may differentially affect a CB1 cannabinoid receptor ligand's affinity and efficacy.The activities of a number of side-chain analogues of delta-8-tetrahydrocannabinol (Δ8-THC) in rat cerebellar membrane preparations were tested.The affinities of each compound for the CB1 receptor were compared by their respective abilities to displace [3H]-SR141716A and their efficacies compared by stimulation of [35S]-GTPγS binding.It was found that the affinities varied from 0.19±0.03 nM for 3-norpentyl-3-[6′-cyano,1′,1′-dimethyl]hexyl-Δ8-THC to 395±66.3 nM for 5′-[N-(4-chlorophenyl)]-1′,1′-dimethyl-carboxamido-Δ8-THC.The efficacies of these compounds varied greatly, ranging from the very low efficacy exhibited to acetylenic compounds such as 1′-heptyn-Δ8-THC and 4′-octyn-Δ8-THC to higher efficacy compounds such as 5′-(4-cyanophenoxy)-1′,1′-dimethyl-Δ8-THC and 5′-[N-(4-aminosulphonylphenyl)]-1′,1′ dimethyl-carboxamido Δ8-THC. All agonist activities were antagonized by the CB1-selective antagonist SR141716A.It was found that a ligand's CB1 affinity and efficacy are differentially altered by modifications in the side-chain. Decreasing the flexibility of the side-chain reduced efficacy but largely did not alter affinity. Additionally, the positioning of electrostatic moieties, such as cyano groups, within the side-chain also has contrasting effects on these two properties.In summary, this report details the characterization of a number of novel Δ8-THC analogues in rat cerebellar membranes. It provides the first detailed pharmacological analysis of how the inclusion of electrostatic moieties in the side-chain and also how alteration of the side-chain's flexibility may differentially affect a CB1 cannabinoid receptor ligand's affinity and efficacy.British Journal of Pharmacology (2001) 132, 525–535; doi:10.1038/sj.bjp.0703827","downloadable_attachments":[{"id":46328529,"asset_id":12157948,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":30524353,"first_name":"Mie Mie","last_name":"Aung","domain_name":"independent","page_name":"AungMieMie","display_name":"Mie Mie Aung","profile_url":"https://independent.academia.edu/AungMieMie?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":7324,"name":"British","url":"https://www.academia.edu/Documents/in/British?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615","nofollow":true},{"id":432361,"name":"Radioligand Assay","url":"https://www.academia.edu/Documents/in/Radioligand_Assay?f_ri=65615","nofollow":true},{"id":596681,"name":"Carboxylic Acids","url":"https://www.academia.edu/Documents/in/Carboxylic_Acids?f_ri=65615"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship?f_ri=65615"},{"id":1959362,"name":"Cannabinoid Receptor","url":"https://www.academia.edu/Documents/in/Cannabinoid_Receptor?f_ri=65615"},{"id":2468093,"name":"Cell Membrane","url":"https://www.academia.edu/Documents/in/Cell_Membrane?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14832495" data-work_id="14832495" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14832495/Early_maternal_deprivation_in_rats_induces_gender_dependent_effects_on_developing_hippocampal_and_cerebellar_cells">Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div 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class="js-view-count-work_14832495 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14832495"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14832495; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14832495]").text(description); $(".js-view-count-work_14832495").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14832495").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14832495"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8322" rel="nofollow" href="https://www.academia.edu/Documents/in/Developmental_neuroscience">Developmental neuroscience</a>, <script data-card-contents-for-ri="8322" type="text/json">{"id":8322,"name":"Developmental neuroscience","url":"https://www.academia.edu/Documents/in/Developmental_neuroscience?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57556" rel="nofollow" href="https://www.academia.edu/Documents/in/Hippocampus">Hippocampus</a>, <script data-card-contents-for-ri="57556" type="text/json">{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62550" rel="nofollow" href="https://www.academia.edu/Documents/in/Pregnancy">Pregnancy</a><script data-card-contents-for-ri="62550" type="text/json">{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14832495]'), work: {"id":14832495,"title":"Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells","created_at":"2015-08-10T13:01:53.061-07:00","url":"https://www.academia.edu/14832495/Early_maternal_deprivation_in_rats_induces_gender_dependent_effects_on_developing_hippocampal_and_cerebellar_cells?f_ri=65615","dom_id":"work_14832495","summary":null,"downloadable_attachments":[{"id":43866544,"asset_id":14832495,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33791457,"first_name":"Luis Miguel","last_name":"Garcia-Segura","domain_name":"csic","page_name":"LuisMiguelGarciaSegura","display_name":"Luis Miguel Garcia-Segura","profile_url":"https://csic.academia.edu/LuisMiguelGarciaSegura?f_ri=65615","photo":"https://0.academia-photos.com/33791457/40993176/33378599/s65_luis_miguel.garcia-segura.jpg"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=65615","nofollow":true},{"id":8322,"name":"Developmental neuroscience","url":"https://www.academia.edu/Documents/in/Developmental_neuroscience?f_ri=65615","nofollow":true},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=65615","nofollow":true},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":75509,"name":"Sex Difference","url":"https://www.academia.edu/Documents/in/Sex_Difference?f_ri=65615"},{"id":130116,"name":"Astrocyte","url":"https://www.academia.edu/Documents/in/Astrocyte?f_ri=65615"},{"id":171144,"name":"Mental Disorders","url":"https://www.academia.edu/Documents/in/Mental_Disorders?f_ri=65615"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=65615"},{"id":196442,"name":"Astrocytes","url":"https://www.academia.edu/Documents/in/Astrocytes?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=65615"},{"id":436755,"name":"Degeneration","url":"https://www.academia.edu/Documents/in/Degeneration?f_ri=65615"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=65615"},{"id":620661,"name":"High Density Concrete","url":"https://www.academia.edu/Documents/in/High_Density_Concrete?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":1297608,"name":"Organic Chemicals","url":"https://www.academia.edu/Documents/in/Organic_Chemicals?f_ri=65615"},{"id":1801537,"name":"Maternal Deprivation","url":"https://www.academia.edu/Documents/in/Maternal_Deprivation?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_4680271" data-work_id="4680271" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/4680271/The_cognitive_cerebellum_A_big_role_in_psychology_for_the_little_brain">The cognitive cerebellum: A big role in psychology for the 'little brain'?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Most contemporary text books of neurology and of psychology pay little attention to the function of the cerebellum beyond noting it to be an organ of motor control. A historical overview of research on cerebellar function is presented,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_4680271" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Most contemporary text books of neurology and of psychology pay little attention to the function of the cerebellum beyond noting it to be an organ of motor control. A historical overview of research on cerebellar function is presented, from pre-Sherrinton suggestions of sensory and motor function, through the post-Sherrinton and dominant 20 th . Century view of "motor" function, to the 21 st . century perspective of "sensorimotor" function. The intrinsic capability of the cerebellum is briefly considered in terms of: its size/complexity/capacity; its information representation/processing characteristics (with "a particular computational function"); its sensory information processing capability; and, its role in sensorimotor regulatory control. It is suggested that the cerebellum can process sensorimotor stimulus information in a statistical (connectionist type) manner and respond to in on the basis of its own learning based sensorimotor representations, albeit at a "level" that does not necessarily involve cerebral "awareness".</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/4680271" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="82ffe9516cc4d21436e09c62834ab824" rel="nofollow" data-download="{"attachment_id":32016049,"asset_id":4680271,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/32016049/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5068174" href="https://independent.academia.edu/EricParkins">Eric Parkins</a><script data-card-contents-for-user="5068174" type="text/json">{"id":5068174,"first_name":"Eric","last_name":"Parkins","domain_name":"independent","page_name":"EricParkins","display_name":"Eric Parkins","profile_url":"https://independent.academia.edu/EricParkins?f_ri=65615","photo":"https://0.academia-photos.com/5068174/2211302/2663294/s65_eric.parkins.jpg"}</script></span></span></li><li class="js-paper-rank-work_4680271 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="4680271"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 4680271, container: ".js-paper-rank-work_4680271", }); 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Strategies","url":"https://www.academia.edu/Documents/in/Whole_Brain_Teaching_and_Learning_Strategies?f_ri=65615"},{"id":1186642,"name":"Child Clinical Neuropsychology","url":"https://www.academia.edu/Documents/in/Child_Clinical_Neuropsychology?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_541448" data-work_id="541448" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/541448/Boxing_and_chronic_brain_damage">Boxing and chronic brain damage.</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A chronic, and at times, progressive neurologic syndrome associated with boxing has been recognized for some time by boxing fans and people involved with the sport. Since Martland&amp;#39;s first description of the syndrome in 1929, there... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_541448" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A chronic, and at times, progressive neurologic syndrome associated with boxing has been recognized for some time by boxing fans and people involved with the sport. Since Martland&amp;#39;s first description of the syndrome in 1929, there has been only one randomly selected study of ex-boxers, that of Roberts, which showed a 17 per cent prevalence of this syndrome among boxers who fought between 1929 and 1955. This syndrome can be progressive but often is not. Furthermore, the extent of occupational exposure is probably a significant risk factor. Because of this, it would be expected that the prevalance of the syndrome in the modern boxer, as well as the amateur, would be significantly less than during the first half of the century, and, indeed, several studies appear to support this. Recent studies provide evidence that brain damage does exist in modern boxers and suggests that &amp;quot;subclinical&amp;quot; brain damage is likely to be more prevalent than obvious clinical dysfunction. There is clearly a discrepancy between subclinical evidence of neurologic involvement (for example, an abnormal CT scan) and signs of clinical neurologic dysfunction (for example, clinical exam and neuropsychological testing). The latter tend to show less frequent and consistent evidence of brain damage in boxers than does the CT scan. Although it is tempting to assume that an abnormal CT scan presages the development of neurologic dysfunction, it is not clear that this is the case. The prevalence of the syndrome, risk for progression to functional deficit, warning signs, and the natural history cannot be defined at this time. The only way to better define these parameters would be a controlled prospective study, which has yet to be undertaken.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/541448" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4497d943ea9ca25f0f45a1c8a4c8745a" rel="nofollow" data-download="{"attachment_id":51488073,"asset_id":541448,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51488073/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="411288" href="https://stelizabethshospitalresidency.academia.edu/JohnStiller">John W Stiller</a><script data-card-contents-for-user="411288" type="text/json">{"id":411288,"first_name":"John","last_name":"Stiller","domain_name":"stelizabethshospitalresidency","page_name":"JohnStiller","display_name":"John W Stiller","profile_url":"https://stelizabethshospitalresidency.academia.edu/JohnStiller?f_ri=65615","photo":"https://0.academia-photos.com/411288/129669/149536/s65_john.stiller.jpg"}</script></span></span></li><li class="js-paper-rank-work_541448 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="541448"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 541448, container: ".js-paper-rank-work_541448", }); 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$(".js-view-count[data-work-id=541448]").text(description); $(".js-view-count-work_541448").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_541448").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="541448"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="10904" rel="nofollow" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="14788" rel="nofollow" href="https://www.academia.edu/Documents/in/Boxing">Boxing</a>, <script data-card-contents-for-ri="14788" type="text/json">{"id":14788,"name":"Boxing","url":"https://www.academia.edu/Documents/in/Boxing?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="159970" rel="nofollow" href="https://www.academia.edu/Documents/in/Substantia_nigra">Substantia nigra</a><script data-card-contents-for-ri="159970" type="text/json">{"id":159970,"name":"Substantia nigra","url":"https://www.academia.edu/Documents/in/Substantia_nigra?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=541448]'), work: {"id":541448,"title":"Boxing and chronic brain damage.","created_at":"2011-04-22T19:56:17.117-07:00","url":"https://www.academia.edu/541448/Boxing_and_chronic_brain_damage?f_ri=65615","dom_id":"work_541448","summary":"A chronic, and at times, progressive neurologic syndrome associated with boxing has been recognized for some time by boxing fans and people involved with the sport. Since Martland\u0026amp;#39;s first description of the syndrome in 1929, there has been only one randomly selected study of ex-boxers, that of Roberts, which showed a 17 per cent prevalence of this syndrome among boxers who fought between 1929 and 1955. This syndrome can be progressive but often is not. Furthermore, the extent of occupational exposure is probably a significant risk factor. Because of this, it would be expected that the prevalance of the syndrome in the modern boxer, as well as the amateur, would be significantly less than during the first half of the century, and, indeed, several studies appear to support this. Recent studies provide evidence that brain damage does exist in modern boxers and suggests that \u0026amp;quot;subclinical\u0026amp;quot; brain damage is likely to be more prevalent than obvious clinical dysfunction. There is clearly a discrepancy between subclinical evidence of neurologic involvement (for example, an abnormal CT scan) and signs of clinical neurologic dysfunction (for example, clinical exam and neuropsychological testing). The latter tend to show less frequent and consistent evidence of brain damage in boxers than does the CT scan. Although it is tempting to assume that an abnormal CT scan presages the development of neurologic dysfunction, it is not clear that this is the case. The prevalence of the syndrome, risk for progression to functional deficit, warning signs, and the natural history cannot be defined at this time. The only way to better define these parameters would be a controlled prospective study, which has yet to be undertaken.","downloadable_attachments":[{"id":51488073,"asset_id":541448,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":411288,"first_name":"John","last_name":"Stiller","domain_name":"stelizabethshospitalresidency","page_name":"JohnStiller","display_name":"John W Stiller","profile_url":"https://stelizabethshospitalresidency.academia.edu/JohnStiller?f_ri=65615","photo":"https://0.academia-photos.com/411288/129669/149536/s65_john.stiller.jpg"}],"research_interests":[{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=65615","nofollow":true},{"id":14788,"name":"Boxing","url":"https://www.academia.edu/Documents/in/Boxing?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":159970,"name":"Substantia nigra","url":"https://www.academia.edu/Documents/in/Substantia_nigra?f_ri=65615","nofollow":true},{"id":357850,"name":"Atrophy","url":"https://www.academia.edu/Documents/in/Atrophy?f_ri=65615"},{"id":548890,"name":"Locus coeruleus","url":"https://www.academia.edu/Documents/in/Locus_coeruleus?f_ri=65615"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=65615"},{"id":1218490,"name":"Psychiatric Clinics of North America","url":"https://www.academia.edu/Documents/in/Psychiatric_Clinics_of_North_America?f_ri=65615"},{"id":2463663,"name":"Neurologic Examination","url":"https://www.academia.edu/Documents/in/Neurologic_Examination?f_ri=65615"},{"id":2467548,"name":"Neuropsychological Tests","url":"https://www.academia.edu/Documents/in/Neuropsychological_Tests?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_8663787" data-work_id="8663787" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/8663787/The_central_adrenergic_system_An_immunofluorescence_study_of_the_location_of_cell_bodies_and_their_efferent_connections_in_the_rat_utilizing_dopamine_B_hydroxylase_as_a_marker">The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-B-hydroxylase as a marker</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A sensitive immunofluorescene technique was used to describe systematically the distribution of dopamine-β-hydroxylase (DBH)-containing cell bodies, non-terminal fiber pathways, and terminal fields in the brain of the male albino rat. DBH... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_8663787" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A sensitive immunofluorescene technique was used to describe systematically the distribution of dopamine-β-hydroxylase (DBH)-containing cell bodies, non-terminal fiber pathways, and terminal fields in the brain of the male albino rat. DBH is the enzyme that catalyzes the conversion of dopamine to noradrenaline, and as such is useful as an anatomical marker for noradrenaline and possibly adrenaline neurons. The enzyme is not present in dopamine- or indolamine-containing neurons. Ten micron frozen sections (1-in-20 series) were prepared in the frontal, sagittal, and horizontal planes from the olfactory bulb to the upper cervical segments of the spinal cord; adjacent sections in each plane were stained for DBH and for cells (toluidine blue-azure II). An atlas consisting of 40 projection drawings of selected frontal sections illustrates the results of the investigation. DBH perikarya are confined to three groups in the pons and medulla: the well defined locus coeruleus, a more diffuse but continuous subcoeruleus group that arches through the pons and ventral medulla, and a third dorsal medullary group centered in the dorsal motor nucleus of the vagus. A single principal adrenergic fiber system distributes a great many of the axons from these neuron groups to a majority of nuclear areas in the brain. In the pons and medulla two components of the fiber system may be distinguished. A medullary branch may be followed from the posterior aspect of the subcoeruleus group dorsally and then anteriorly through the lateral tegmental field and ventral aspect of the vestibular complex to a position subjacent to the locus coeruleus, where it is joined by a subcoeruleus branch consisting of a large number of fibers coursing among cells along the length of the subcoeruleus group, and by fibers arising from the locus coeruleus. Anterior to the locus coeruleus the principal adrenergic bundle courses as a single fiber tract immediately ventrolateral to the central gray in the mesencephalon and in the zona incerta and substantia innominata in the diencephalon. At the level of the septal area separate bundles reach the cortex dorsally over the genu of the corpus callosum via the medial septal-diagonal band nuclei and the lateral septum and ventrally between the olfactory tubercle and caudate-putamen. In the medulla and pons adrenergic fibers undoubtedly course in both directions. Anterior to the most rostral pontine cell bodies, however, all fibers presumably ascend. Along the course of the bundle distinct branches emerge to innervate circumscribed terminal fields. In addition, certain regions of the brain such as the reticular formation and pontine gray receive diffuse DBH innervation derived from less clearly defined pathways. A small number of areas in the brain contain little or no detectable DBH. These include the caudate-putamen, nucleus accumbens, globus pallidus, olfactory tubercle, subthalamic nucleus, substantia nigra, pretectal area, third, fourth and sixth cranial nerve nuclei, and the trapezoid body nucleus.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/8663787" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4173ae42b8990d0928dd03e45baa4e0a" rel="nofollow" data-download="{"attachment_id":48027560,"asset_id":8663787,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48027560/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="18097071" href="https://argosy.academia.edu/BK">B K</a><script data-card-contents-for-user="18097071" type="text/json">{"id":18097071,"first_name":"B","last_name":"K","domain_name":"argosy","page_name":"BK","display_name":"B K","profile_url":"https://argosy.academia.edu/BK?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_8663787 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="8663787"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 8663787, container: ".js-paper-rank-work_8663787", }); 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$(".js-view-count[data-work-id=8663787]").text(description); $(".js-view-count-work_8663787").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_8663787").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="8663787"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="173" rel="nofollow" href="https://www.academia.edu/Documents/in/Zoology">Zoology</a>, <script data-card-contents-for-ri="173" type="text/json">{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52176" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain_Mapping">Brain Mapping</a>, <script data-card-contents-for-ri="52176" type="text/json">{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57556" rel="nofollow" href="https://www.academia.edu/Documents/in/Hippocampus">Hippocampus</a>, <script data-card-contents-for-ri="57556" type="text/json">{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="61474" rel="nofollow" href="https://www.academia.edu/Documents/in/Brain">Brain</a><script data-card-contents-for-ri="61474" type="text/json">{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=8663787]'), work: {"id":8663787,"title":"The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-B-hydroxylase as a marker","created_at":"2014-10-06T17:13:40.365-07:00","url":"https://www.academia.edu/8663787/The_central_adrenergic_system_An_immunofluorescence_study_of_the_location_of_cell_bodies_and_their_efferent_connections_in_the_rat_utilizing_dopamine_B_hydroxylase_as_a_marker?f_ri=65615","dom_id":"work_8663787","summary":"A sensitive immunofluorescene technique was used to describe systematically the distribution of dopamine-β-hydroxylase (DBH)-containing cell bodies, non-terminal fiber pathways, and terminal fields in the brain of the male albino rat. DBH is the enzyme that catalyzes the conversion of dopamine to noradrenaline, and as such is useful as an anatomical marker for noradrenaline and possibly adrenaline neurons. The enzyme is not present in dopamine- or indolamine-containing neurons. Ten micron frozen sections (1-in-20 series) were prepared in the frontal, sagittal, and horizontal planes from the olfactory bulb to the upper cervical segments of the spinal cord; adjacent sections in each plane were stained for DBH and for cells (toluidine blue-azure II). An atlas consisting of 40 projection drawings of selected frontal sections illustrates the results of the investigation. DBH perikarya are confined to three groups in the pons and medulla: the well defined locus coeruleus, a more diffuse but continuous subcoeruleus group that arches through the pons and ventral medulla, and a third dorsal medullary group centered in the dorsal motor nucleus of the vagus. A single principal adrenergic fiber system distributes a great many of the axons from these neuron groups to a majority of nuclear areas in the brain. In the pons and medulla two components of the fiber system may be distinguished. A medullary branch may be followed from the posterior aspect of the subcoeruleus group dorsally and then anteriorly through the lateral tegmental field and ventral aspect of the vestibular complex to a position subjacent to the locus coeruleus, where it is joined by a subcoeruleus branch consisting of a large number of fibers coursing among cells along the length of the subcoeruleus group, and by fibers arising from the locus coeruleus. Anterior to the locus coeruleus the principal adrenergic bundle courses as a single fiber tract immediately ventrolateral to the central gray in the mesencephalon and in the zona incerta and substantia innominata in the diencephalon. At the level of the septal area separate bundles reach the cortex dorsally over the genu of the corpus callosum via the medial septal-diagonal band nuclei and the lateral septum and ventrally between the olfactory tubercle and caudate-putamen. In the medulla and pons adrenergic fibers undoubtedly course in both directions. Anterior to the most rostral pontine cell bodies, however, all fibers presumably ascend. Along the course of the bundle distinct branches emerge to innervate circumscribed terminal fields. In addition, certain regions of the brain such as the reticular formation and pontine gray receive diffuse DBH innervation derived from less clearly defined pathways. A small number of areas in the brain contain little or no detectable DBH. These include the caudate-putamen, nucleus accumbens, globus pallidus, olfactory tubercle, subthalamic nucleus, substantia nigra, pretectal area, third, fourth and sixth cranial nerve nuclei, and the trapezoid body nucleus.","downloadable_attachments":[{"id":48027560,"asset_id":8663787,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":18097071,"first_name":"B","last_name":"K","domain_name":"argosy","page_name":"BK","display_name":"B K","profile_url":"https://argosy.academia.edu/BK?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=65615","nofollow":true},{"id":52176,"name":"Brain 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Lobe","url":"https://www.academia.edu/Documents/in/Parietal_Lobe?f_ri=65615"},{"id":1257483,"name":"Frontal Lobe","url":"https://www.academia.edu/Documents/in/Frontal_Lobe?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14022796" data-work_id="14022796" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14022796/Effects_of_diazepam_on_extracellular_brain_neurotransmitters_in_pilocarpine_induced_seizures_in_rats">Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced Ž . seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14022796" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced Ž . seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA g-aminobutyric acid and Ž . dopamine. In vivo microdialysis, coupled to continuous monitoring of electrocorticographic ECoG recordings, was performed in freely Ž . moving rats. Intrahippocampal perfusion with 10 mM pilocarpine 40 min, 2 mlrmin produced limbic seizures. A single dose of Ž . intraperitoneal diazepam 5 mgrkg was administered 2 h after pilocarpine perfusion was started. Dialysates were sampled both from hippocampus and cerebellum and analysed by microbore liquid chromatography. Diazepam produced instant inhibition of behavioural and ECoG seizure activity. Pilocarpine-induced increases in the extracellular levels of glutamate and dopamine in hippocampus were promptly reduced by diazepam. No concurrent alterations in pilocarpine-induced increases in the extracellular levels of GABA in either hippocampus or cerebellum were seen. Pilocarpine enhanced cerebellar glutamate levels only transiently and levels returned to baseline before diazepam administration. No further changes in cerebellar glutamate levels were observed with diazepam. Our findings suggest that the anti-convulsant action of diazepam against pilocarpine-induced seizures is associated with a prompt attenuation of extracellular hippocampal glutamate overflow without concurrent alteration of pilocarpine-induced increases in endogenous GABA levels. Diazepam also significantly decreased pilocarpine-induced increases in extracellular dopamine levels within the hippocampus. No immediate alterations of the basal levels of the neurotransmitters monitored were observed with diazepam. q</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14022796" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3edf80c54e35ef213415060fe0ab7b82" rel="nofollow" data-download="{"attachment_id":44696147,"asset_id":14022796,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44696147/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33053318" href="https://vub.academia.edu/YvetteMichotte">Yvette Michotte</a><script data-card-contents-for-user="33053318" type="text/json">{"id":33053318,"first_name":"Yvette","last_name":"Michotte","domain_name":"vub","page_name":"YvetteMichotte","display_name":"Yvette Michotte","profile_url":"https://vub.academia.edu/YvetteMichotte?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14022796 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14022796"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14022796, container: ".js-paper-rank-work_14022796", }); 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In vivo microdialysis, coupled to continuous monitoring of electrocorticographic ECoG recordings, was performed in freely Ž . moving rats. Intrahippocampal perfusion with 10 mM pilocarpine 40 min, 2 mlrmin produced limbic seizures. A single dose of Ž . intraperitoneal diazepam 5 mgrkg was administered 2 h after pilocarpine perfusion was started. Dialysates were sampled both from hippocampus and cerebellum and analysed by microbore liquid chromatography. Diazepam produced instant inhibition of behavioural and ECoG seizure activity. Pilocarpine-induced increases in the extracellular levels of glutamate and dopamine in hippocampus were promptly reduced by diazepam. No concurrent alterations in pilocarpine-induced increases in the extracellular levels of GABA in either hippocampus or cerebellum were seen. Pilocarpine enhanced cerebellar glutamate levels only transiently and levels returned to baseline before diazepam administration. No further changes in cerebellar glutamate levels were observed with diazepam. Our findings suggest that the anti-convulsant action of diazepam against pilocarpine-induced seizures is associated with a prompt attenuation of extracellular hippocampal glutamate overflow without concurrent alteration of pilocarpine-induced increases in endogenous GABA levels. Diazepam also significantly decreased pilocarpine-induced increases in extracellular dopamine levels within the hippocampus. No immediate alterations of the basal levels of the neurotransmitters monitored were observed with diazepam. q","downloadable_attachments":[{"id":44696147,"asset_id":14022796,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33053318,"first_name":"Yvette","last_name":"Michotte","domain_name":"vub","page_name":"YvetteMichotte","display_name":"Yvette Michotte","profile_url":"https://vub.academia.edu/YvetteMichotte?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2749,"name":"Animal Behavior","url":"https://www.academia.edu/Documents/in/Animal_Behavior?f_ri=65615","nofollow":true},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=65615","nofollow":true},{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine?f_ri=65615","nofollow":true},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=65615","nofollow":true},{"id":61233,"name":"Glutamate","url":"https://www.academia.edu/Documents/in/Glutamate?f_ri=65615"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615"},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=65615"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":390353,"name":"Pilocarpine","url":"https://www.academia.edu/Documents/in/Pilocarpine?f_ri=65615"},{"id":398287,"name":"Liquid Chromatography","url":"https://www.academia.edu/Documents/in/Liquid_Chromatography?f_ri=65615"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats?f_ri=65615"},{"id":651604,"name":"Seizures","url":"https://www.academia.edu/Documents/in/Seizures?f_ri=65615"},{"id":725615,"name":"Mechanism of action","url":"https://www.academia.edu/Documents/in/Mechanism_of_action?f_ri=65615"},{"id":853012,"name":"Diazepam","url":"https://www.academia.edu/Documents/in/Diazepam?f_ri=65615"},{"id":1281442,"name":"Extracellular Space","url":"https://www.academia.edu/Documents/in/Extracellular_Space?f_ri=65615"},{"id":1619808,"name":"Gamma-Aminobutyric Acid","url":"https://www.academia.edu/Documents/in/Gamma-Aminobutyric_Acid?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17294895" data-work_id="17294895" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/17294895/Balance_disorders_in_headache_patients_evaluation_by_computerized_static_stabilometry">Balance disorders in headache patients: evaluation by computerized static stabilometry</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of the study was to investigate the occurrence of equilibrium disturbances in headache patients, during the interictal period, by computerized static stabilometry. Sixty-seven patients were studied: 35 with migraine without aura... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17294895" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of the study was to investigate the occurrence of equilibrium disturbances in headache patients, during the interictal period, by computerized static stabilometry. Sixty-seven patients were studied: 35 with migraine without aura (MwoA), 12 with tension-type headache (TTH) in the episodic form (ETTH) + MwoA, and 20 with only TTH [10 ETTH + 10 chronic (CTTH)]. The stabilometric parameters considered were: statokinesigram length (L) and surface (S) in open (EO) and closed (EC) eyes conditions with/without occlusal bite, EC with head retroflexion (ECR), and optokinetic stimulation (OKN). The alteration of at least one of the stabilometric parameters was observed in 45 patients (67.2%): 21 MwoA, 8 ETTH + MwoA, and 16 TTH (8 ETTH + 8 CTTH). In TTH patients (ETTH, CTTH, ETTH + MwoA), the stabilometric findings show a proprioceptive alteration induced by cervicofacial muscle contraction, which was peripheral in origin. In MwoA patients the alterations appear under OKN and support a control impairment in involuntary oculomotility of central origin.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17294895" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="765d60ec6206f80c2b3daa5194a09f80" rel="nofollow" data-download="{"attachment_id":42271716,"asset_id":17294895,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42271716/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36967273" href="https://independent.academia.edu/GiovanniMazzotta">Giovanni Mazzotta</a><script data-card-contents-for-user="36967273" type="text/json">{"id":36967273,"first_name":"Giovanni","last_name":"Mazzotta","domain_name":"independent","page_name":"GiovanniMazzotta","display_name":"Giovanni Mazzotta","profile_url":"https://independent.academia.edu/GiovanniMazzotta?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17294895 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17294895"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17294895, container: ".js-paper-rank-work_17294895", }); 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$(".js-view-count[data-work-id=17294895]").text(description); $(".js-view-count-work_17294895").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_17294895").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="17294895"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="28973" rel="nofollow" href="https://www.academia.edu/Documents/in/Comorbidity">Comorbidity</a>, <script data-card-contents-for-ri="28973" type="text/json">{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="143507" rel="nofollow" href="https://www.academia.edu/Documents/in/Eye_Movements">Eye Movements</a>, <script data-card-contents-for-ri="143507" type="text/json">{"id":143507,"name":"Eye Movements","url":"https://www.academia.edu/Documents/in/Eye_Movements?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=17294895]'), work: {"id":17294895,"title":"Balance disorders in headache patients: evaluation by computerized static stabilometry","created_at":"2015-10-26T01:08:37.184-07:00","url":"https://www.academia.edu/17294895/Balance_disorders_in_headache_patients_evaluation_by_computerized_static_stabilometry?f_ri=65615","dom_id":"work_17294895","summary":"The aim of the study was to investigate the occurrence of equilibrium disturbances in headache patients, during the interictal period, by computerized static stabilometry. Sixty-seven patients were studied: 35 with migraine without aura (MwoA), 12 with tension-type headache (TTH) in the episodic form (ETTH) + MwoA, and 20 with only TTH [10 ETTH + 10 chronic (CTTH)]. The stabilometric parameters considered were: statokinesigram length (L) and surface (S) in open (EO) and closed (EC) eyes conditions with/without occlusal bite, EC with head retroflexion (ECR), and optokinetic stimulation (OKN). The alteration of at least one of the stabilometric parameters was observed in 45 patients (67.2%): 21 MwoA, 8 ETTH + MwoA, and 16 TTH (8 ETTH + 8 CTTH). In TTH patients (ETTH, CTTH, ETTH + MwoA), the stabilometric findings show a proprioceptive alteration induced by cervicofacial muscle contraction, which was peripheral in origin. In MwoA patients the alterations appear under OKN and support a control impairment in involuntary oculomotility of central origin.","downloadable_attachments":[{"id":42271716,"asset_id":17294895,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36967273,"first_name":"Giovanni","last_name":"Mazzotta","domain_name":"independent","page_name":"GiovanniMazzotta","display_name":"Giovanni Mazzotta","profile_url":"https://independent.academia.edu/GiovanniMazzotta?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":28973,"name":"Comorbidity","url":"https://www.academia.edu/Documents/in/Comorbidity?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":143507,"name":"Eye Movements","url":"https://www.academia.edu/Documents/in/Eye_Movements?f_ri=65615","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=65615","nofollow":true},{"id":704276,"name":"Postural Balance","url":"https://www.academia.edu/Documents/in/Postural_Balance?f_ri=65615"},{"id":1414600,"name":"Vestibular Diseases","url":"https://www.academia.edu/Documents/in/Vestibular_Diseases?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_62998450" data-work_id="62998450" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/62998450/Surface_anatomy_of_the_transverse_sinus_for_the_midline_infratentorial_supracerebellar_approach">Surface anatomy of the transverse sinus for the midline infratentorial supracerebellar approach</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">AIM Knowing the location of the transverse sinus in the midline supracerebellar infratentorial approach is important to prevent its inadvertent injury. The external landmarks of the occipital bone have been studied in this anatomic study... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62998450" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">AIM Knowing the location of the transverse sinus in the midline supracerebellar infratentorial approach is important to prevent its inadvertent injury. The external landmarks of the occipital bone have been studied in this anatomic study in order to reveal their relationship with the transverse sinus. MATERIAL AND METHODS Fifty-two dried skulls were used to study the relationship of the transverse sinus with various surface bone structures. The key bone surface structures identified in each specimen were the superior nuchal line, the inferior nuchal line, the inion, internal occipital protuberance, and the transverse sulcus. RESULTS The distance from the inion to the inferior nuchal line in specimens ranged from 12.7 mm to 37.7 mm. The distance from the inferior nuchal line to the midline foramen magnum in the specimens ranged from 19 mm to 34.75 mm. The width of the proximal transverse sulcus ranged from 2.6 mm to 10.16 mm with an average of 6.43 mm on the right side and 3.4 mm to ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62998450" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4e015321a003f1004b2eb36b0e6331f2" rel="nofollow" data-download="{"attachment_id":75575033,"asset_id":62998450,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75575033/download_file?st=MTczODU4Mzg1Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="59479428" href="https://independent.academia.edu/HikmetTuran">Hikmet Turan</a><script data-card-contents-for-user="59479428" type="text/json">{"id":59479428,"first_name":"Hikmet","last_name":"Turan","domain_name":"independent","page_name":"HikmetTuran","display_name":"Hikmet Turan","profile_url":"https://independent.academia.edu/HikmetTuran?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_62998450 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62998450"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62998450, container: ".js-paper-rank-work_62998450", }); 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$(".js-view-count[data-work-id=62998450]").text(description); $(".js-view-count-work_62998450").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_62998450").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="62998450"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="65615" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebellum">Cerebellum</a>, <script data-card-contents-for-ri="65615" type="text/json">{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="107350" rel="nofollow" href="https://www.academia.edu/Documents/in/Skull">Skull</a>, <script data-card-contents-for-ri="107350" type="text/json">{"id":107350,"name":"Skull","url":"https://www.academia.edu/Documents/in/Skull?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="247948" rel="nofollow" href="https://www.academia.edu/Documents/in/Cadaver">Cadaver</a>, <script data-card-contents-for-ri="247948" type="text/json">{"id":247948,"name":"Cadaver","url":"https://www.academia.edu/Documents/in/Cadaver?f_ri=65615","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="440924" rel="nofollow" href="https://www.academia.edu/Documents/in/Surface_Properties">Surface Properties</a><script data-card-contents-for-ri="440924" type="text/json">{"id":440924,"name":"Surface Properties","url":"https://www.academia.edu/Documents/in/Surface_Properties?f_ri=65615","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=62998450]'), work: {"id":62998450,"title":"Surface anatomy of the transverse sinus for the midline infratentorial supracerebellar approach","created_at":"2021-12-02T09:09:54.860-08:00","url":"https://www.academia.edu/62998450/Surface_anatomy_of_the_transverse_sinus_for_the_midline_infratentorial_supracerebellar_approach?f_ri=65615","dom_id":"work_62998450","summary":"AIM Knowing the location of the transverse sinus in the midline supracerebellar infratentorial approach is important to prevent its inadvertent injury. The external landmarks of the occipital bone have been studied in this anatomic study in order to reveal their relationship with the transverse sinus. MATERIAL AND METHODS Fifty-two dried skulls were used to study the relationship of the transverse sinus with various surface bone structures. The key bone surface structures identified in each specimen were the superior nuchal line, the inferior nuchal line, the inion, internal occipital protuberance, and the transverse sulcus. RESULTS The distance from the inion to the inferior nuchal line in specimens ranged from 12.7 mm to 37.7 mm. The distance from the inferior nuchal line to the midline foramen magnum in the specimens ranged from 19 mm to 34.75 mm. The width of the proximal transverse sulcus ranged from 2.6 mm to 10.16 mm with an average of 6.43 mm on the right side and 3.4 mm to ...","downloadable_attachments":[{"id":75575033,"asset_id":62998450,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":59479428,"first_name":"Hikmet","last_name":"Turan","domain_name":"independent","page_name":"HikmetTuran","display_name":"Hikmet Turan","profile_url":"https://independent.academia.edu/HikmetTuran?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":107350,"name":"Skull","url":"https://www.academia.edu/Documents/in/Skull?f_ri=65615","nofollow":true},{"id":247948,"name":"Cadaver","url":"https://www.academia.edu/Documents/in/Cadaver?f_ri=65615","nofollow":true},{"id":440924,"name":"Surface Properties","url":"https://www.academia.edu/Documents/in/Surface_Properties?f_ri=65615","nofollow":true},{"id":3104605,"name":"Transverse Sinuses","url":"https://www.academia.edu/Documents/in/Transverse_Sinuses?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30179714" data-work_id="30179714" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30179714/Cerebellar_symptoms_heralding_bilirubin_encephalopathy_in_crigler_najjar_syndrome">Cerebellar symptoms heralding bilirubin encephalopathy in crigler-najjar syndrome</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Children with Crigler-Najjar syndrome type I are at increased risk for neurologic deficits. Cerebellar symptoms are not prominent and appear in adolescent or adult patients with this syndrome. We report a 2-yearold female with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_30179714" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Children with Crigler-Najjar syndrome type I are at increased risk for neurologic deficits. Cerebellar symptoms are not prominent and appear in adolescent or adult patients with this syndrome. We report a 2-yearold female with Crigler-Najjar syndrome type I who presented severe cerebellar symptoms revealing bilirubin encephalopathy. The patient improved slowly with the duration of phototherapy. Cerebellar symptoms can be the initial manifestation of kernicterus in children with Crigler-Najjar syndrome type I.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30179714" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="67f4e02e105924a563ee714043598450" rel="nofollow" data-download="{"attachment_id":50637987,"asset_id":30179714,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50637987/download_file?st=MTczODU4Mzg1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="57388979" href="https://independent.academia.edu/BrahimTabarki">Brahim Tabarki</a><script data-card-contents-for-user="57388979" type="text/json">{"id":57388979,"first_name":"Brahim","last_name":"Tabarki","domain_name":"independent","page_name":"BrahimTabarki","display_name":"Brahim Tabarki","profile_url":"https://independent.academia.edu/BrahimTabarki?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30179714 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30179714"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30179714, container: ".js-paper-rank-work_30179714", }); 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Cerebellar symptoms are not prominent and appear in adolescent or adult patients with this syndrome. We report a 2-yearold female with Crigler-Najjar syndrome type I who presented severe cerebellar symptoms revealing bilirubin encephalopathy. The patient improved slowly with the duration of phototherapy. Cerebellar symptoms can be the initial manifestation of kernicterus in children with Crigler-Najjar syndrome type I.","downloadable_attachments":[{"id":50637987,"asset_id":30179714,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":57388979,"first_name":"Brahim","last_name":"Tabarki","domain_name":"independent","page_name":"BrahimTabarki","display_name":"Brahim Tabarki","profile_url":"https://independent.academia.edu/BrahimTabarki?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true},{"id":37791,"name":"Pediatric Neurology","url":"https://www.academia.edu/Documents/in/Pediatric_Neurology?f_ri=65615","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=65615"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=65615"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=65615"},{"id":476432,"name":"Crigler-Najjar syndrome","url":"https://www.academia.edu/Documents/in/Crigler-Najjar_syndrome?f_ri=65615"},{"id":800822,"name":"Neonatal Jaundice","url":"https://www.academia.edu/Documents/in/Neonatal_Jaundice?f_ri=65615"},{"id":857943,"name":"Kernicterus","url":"https://www.academia.edu/Documents/in/Kernicterus?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"},{"id":2463663,"name":"Neurologic Examination","url":"https://www.academia.edu/Documents/in/Neurologic_Examination?f_ri=65615"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_28029892 coauthored" data-work_id="28029892" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/28029892/The_human_startle_reflex_and_pons_activation_a_regional_cerebral_blood_flow_study">The human startle reflex and pons activation: a regional cerebral blood flow study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Using positron emission tomographic measurements of regional cerebral blood¯ow, we report activation of a medial pons area in humans during acoustic startle stimulation. Eight healthy volunteers were scanned during rest and when presented... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_28029892" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Using positron emission tomographic measurements of regional cerebral blood¯ow, we report activation of a medial pons area in humans during acoustic startle stimulation. Eight healthy volunteers were scanned during rest and when presented startle-eliciting stimuli. We performed a theory-driven directed search for activity in the nucleus reticularis pontis caudalis, situated in the pons. Because habituation of cerebellar activity during acoustic startle repetition has been reported [Timmann, D., Musso, C., Kolb, F.P., Rijntjes, M., Juptner, M., Muller, S.P., Diener, H.C. & Weiller, C. (1998) J. Neurol. Neurosurg. Psychiatry 65, 771±773], we also predicted habituation in the cerebellum and in the pons as a function of startle repetition. Measurements of eye electromyography validated the presence of a startle response and its habituation. Analysis of regional cerebral blood¯ow revealed higher neural activity during startle stimulation than at rest in a medial pons area consistent with the location of the pontine reticular nucleus. As a consequence of startle repetition, regional cerebral blood¯ow increased in the medial cerebellum, and habituated in the ventral cerebellum and in a ventral pons area separate from the pontine reticular nucleus. In the ventral pons, but not in the pontine reticular nucleus, regional cerebral blood¯ow and the startle re¯ex were positively correlated. In the cerebellum both positive and negative correlations with the startle re¯ex were observed. Thus we conclude that the neurofunctional correlates of the startle circuit and its habituation in humans are similar to that previously described in animals.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28029892" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="db002c0f73b934a899001ac4418e7ce2" rel="nofollow" data-download="{"attachment_id":48336122,"asset_id":28029892,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48336122/download_file?st=MTczODU4Mzg1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52547058" href="https://independent.academia.edu/MagneFlaten">Magne Flaten</a><script data-card-contents-for-user="52547058" type="text/json">{"id":52547058,"first_name":"Magne","last_name":"Flaten","domain_name":"independent","page_name":"MagneFlaten","display_name":"Magne Flaten","profile_url":"https://independent.academia.edu/MagneFlaten?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-28029892">+1</span><div class="hidden js-additional-users-28029892"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://uppsala.academia.edu/%C3%96rjanFrans">Örjan Frans</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-28029892'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-28029892').html(); 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Eight healthy volunteers were scanned during rest and when presented startle-eliciting stimuli. We performed a theory-driven directed search for activity in the nucleus reticularis pontis caudalis, situated in the pons. Because habituation of cerebellar activity during acoustic startle repetition has been reported [Timmann, D., Musso, C., Kolb, F.P., Rijntjes, M., Juptner, M., Muller, S.P., Diener, H.C. \u0026 Weiller, C. (1998) J. Neurol. Neurosurg. Psychiatry 65, 771±773], we also predicted habituation in the cerebellum and in the pons as a function of startle repetition. Measurements of eye electromyography validated the presence of a startle response and its habituation. Analysis of regional cerebral blood¯ow revealed higher neural activity during startle stimulation than at rest in a medial pons area consistent with the location of the pontine reticular nucleus. As a consequence of startle repetition, regional cerebral blood¯ow increased in the medial cerebellum, and habituated in the ventral cerebellum and in a ventral pons area separate from the pontine reticular nucleus. In the ventral pons, but not in the pontine reticular nucleus, regional cerebral blood¯ow and the startle re¯ex were positively correlated. In the cerebellum both positive and negative correlations with the startle re¯ex were observed. Thus we conclude that the neurofunctional correlates of the startle circuit and its habituation in humans are similar to that previously described in animals.","downloadable_attachments":[{"id":48336122,"asset_id":28029892,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":52547058,"first_name":"Magne","last_name":"Flaten","domain_name":"independent","page_name":"MagneFlaten","display_name":"Magne Flaten","profile_url":"https://independent.academia.edu/MagneFlaten?f_ri=65615","photo":"/images/s65_no_pic.png"},{"id":52602419,"first_name":"Örjan","last_name":"Frans","domain_name":"uppsala","page_name":"ÖrjanFrans","display_name":"Örjan Frans","profile_url":"https://uppsala.academia.edu/%C3%96rjanFrans?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=65615","nofollow":true},{"id":237,"name":"Cognitive 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href="https://www.academia.edu/32810537/Discovery_SAR_and_Pharmacokinetics_of_a_Novel_3_Hydroxyquinolin_2_1_H_one_Series_of_Potent_d_Amino_Acid_Oxidase_DAAO_Inhibitors_">Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1 H )-one Series of Potent d -Amino Acid Oxidase (DAAO) Inhibitors †</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding affinity was confirmed in a Biacore assay. Cocrystallization of 2 with the human... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_32810537" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding affinity was confirmed in a Biacore assay. Cocrystallization of 2 with the human DAAO enzyme defined the binding site and guided the design of new analogues. The SAR, pharmacokinetics, brain exposure, and effects on cerebellum D-serine are described. Subsequent evaluation against the rat DAAO enzyme revealed a divergent SAR versus the human enzyme and may explain the high exposures of drug necessary to achieve significant changes in rat or mouse cerebellum D-serine.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/32810537" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="faf068d1b5c754414c745a33df91fa9c" rel="nofollow" data-download="{"attachment_id":52961903,"asset_id":32810537,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/52961903/download_file?st=MTczODU4Mzg1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="63825210" href="https://independent.academia.edu/AymanElkattan">Ayman El-kattan</a><script data-card-contents-for-user="63825210" type="text/json">{"id":63825210,"first_name":"Ayman","last_name":"El-kattan","domain_name":"independent","page_name":"AymanElkattan","display_name":"Ayman El-kattan","profile_url":"https://independent.academia.edu/AymanElkattan?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_32810537 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="32810537"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 32810537, container: ".js-paper-rank-work_32810537", }); 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Cocrystallization of 2 with the human DAAO enzyme defined the binding site and guided the design of new analogues. The SAR, pharmacokinetics, brain exposure, and effects on cerebellum D-serine are described. 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href="https://www.academia.edu/12434721/Pontocerebellar_hypoplasia_type_2_PCH2_report_of_two_siblings">Pontocerebellar hypoplasia type 2 (PCH2): report of two siblings</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We describe two sisters affected by pontocerebellar hypoplasia type 2 associated with microcephaly, hypertonia, severe choreiform movements, an almost complete lack of psychomotor development, and generalized tonic-clonic seizures.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12434721" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We describe two sisters affected by pontocerebellar hypoplasia type 2 associated with microcephaly, hypertonia, severe choreiform movements, an almost complete lack of psychomotor development, and generalized tonic-clonic seizures. Clinical and neuroradiological ®ndings ruled out other conditions associated with pontocerebellar hypoplasia, i.e. pontocerebellar hypoplasia type 1, carbohydrate-de®cient glycoprotein syndrome, and olivopontocerebellar hypoplasia/atrophy. q</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12434721" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="61ff9b397e637e05894d61e06a019c00" rel="nofollow" data-download="{"attachment_id":46185869,"asset_id":12434721,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46185869/download_file?st=MTczODU4Mzg1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31239858" href="https://independent.academia.edu/GiangennaroCoppola">Giangennaro Coppola</a><script data-card-contents-for-user="31239858" type="text/json">{"id":31239858,"first_name":"Giangennaro","last_name":"Coppola","domain_name":"independent","page_name":"GiangennaroCoppola","display_name":"Giangennaro Coppola","profile_url":"https://independent.academia.edu/GiangennaroCoppola?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12434721 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12434721"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12434721, container: ".js-paper-rank-work_12434721", }); 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Clinical and neuroradiological ®ndings ruled out other conditions associated with pontocerebellar hypoplasia, i.e. pontocerebellar hypoplasia type 1, carbohydrate-de®cient glycoprotein syndrome, and olivopontocerebellar hypoplasia/atrophy. q","downloadable_attachments":[{"id":46185869,"asset_id":12434721,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31239858,"first_name":"Giangennaro","last_name":"Coppola","domain_name":"independent","page_name":"GiangennaroCoppola","display_name":"Giangennaro Coppola","profile_url":"https://independent.academia.edu/GiangennaroCoppola?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6200,"name":"Magnetic Resonance Imaging","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Imaging?f_ri=65615","nofollow":true},{"id":29538,"name":"Brain development","url":"https://www.academia.edu/Documents/in/Brain_development?f_ri=65615","nofollow":true},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases?f_ri=65615","nofollow":true},{"id":65614,"name":"Corpus Callosum","url":"https://www.academia.edu/Documents/in/Corpus_Callosum?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex?f_ri=65615"},{"id":126972,"name":"P-glycoprotein","url":"https://www.academia.edu/Documents/in/P-glycoprotein?f_ri=65615"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=65615"},{"id":188349,"name":"Pedigree","url":"https://www.academia.edu/Documents/in/Pedigree?f_ri=65615"},{"id":322888,"name":"Agenesis of the Corpus Callosum","url":"https://www.academia.edu/Documents/in/Agenesis_of_the_Corpus_Callosum?f_ri=65615"},{"id":341087,"name":"Family Health","url":"https://www.academia.edu/Documents/in/Family_Health?f_ri=65615"},{"id":584615,"name":"Disease Progression","url":"https://www.academia.edu/Documents/in/Disease_Progression?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_17829671" data-work_id="17829671" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/17829671/Sleep_disordered_breathing_Effects_on_brain_structure_and_function">Sleep-disordered breathing: Effects on brain structure and function</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Please cite this article in press as: Harper, R.M., et al., Sleep-disordered breathing: Effects on brain structure and function. 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(2013), http://dx.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17829671" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a3ea9376f0c5b99b0767abbc391b1fbd" rel="nofollow" data-download="{"attachment_id":41954754,"asset_id":17829671,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41954754/download_file?st=MTczODU4Mzg1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37664020" rel="nofollow" href="https://independent.academia.edu/RonaldHarper2">Ronald Harper</a><script data-card-contents-for-user="37664020" type="text/json">{"id":37664020,"first_name":"Ronald","last_name":"Harper","domain_name":"independent","page_name":"RonaldHarper2","display_name":"Ronald Harper","profile_url":"https://independent.academia.edu/RonaldHarper2?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17829671 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17829671"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17829671, container: ".js-paper-rank-work_17829671", }); 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Respir. Physiol. Neurobiol. (2013), http://dx.","downloadable_attachments":[{"id":41954754,"asset_id":17829671,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37664020,"first_name":"Ronald","last_name":"Harper","domain_name":"independent","page_name":"RonaldHarper2","display_name":"Ronald Harper","profile_url":"https://independent.academia.edu/RonaldHarper2?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=65615","nofollow":true},{"id":41220,"name":"Autonomic Nervous System","url":"https://www.academia.edu/Documents/in/Autonomic_Nervous_System?f_ri=65615","nofollow":true},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=65615","nofollow":true},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=65615","nofollow":true},{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex?f_ri=65615"},{"id":104853,"name":"Hormones","url":"https://www.academia.edu/Documents/in/Hormones?f_ri=65615"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=65615"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=65615"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14119000" data-work_id="14119000" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14119000/Differential_modulation_of_the_GYKI_53784_induced_inhibition_of_AMPA_currents_by_various_AMPA_positive_modulators_in_cerebellar_Purkinje_cells">Differential modulation of the GYKI 53784-induced inhibition of AMPA currents by various AMPA-positive modulators in cerebellar Purkinje cells</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Ž . The effects of various S -a-amino-3-hydroxy-5-methyl-4-izoxazole-propionate AMPA receptor modulators on AMPA-induced whole-cell currents were compared in isolated rat cerebellar Purkinje cells. The positive modulators, aniracetam,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14119000" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Ž . The effects of various S -a-amino-3-hydroxy-5-methyl-4-izoxazole-propionate AMPA receptor modulators on AMPA-induced whole-cell currents were compared in isolated rat cerebellar Purkinje cells. The positive modulators, aniracetam, cyclothiazide, Ž . Ž . Ž . Ž . 1-1,3-benzodioxol-5-ylcarbonyl -piperidine 1-BCP , and 1-quinoxaline-6-ylcarbonyl -piperidine BDP-12 , dose-dependently potenti-Ž . Ž . ated the steady-state component of AMPA currents. The negative modulator, y 1-4-aminophenyl -4-methyl-7,8-methylenedioxy-4,5-di-Ž . hydro-3-methylcarbamoyl-2,3-benzodiazepine GYKI 53784 , dose-dependently suppressed AMPA responses. Its concentration-response curve was shifted to the right in a parallel fashion by all positive modulators, indicating a competitive type of interaction. However, the relative potencies of the positive modulators were different with regard to the enhancement of AMPA responses and the reversal of GYKI 53784-induced inhibition, respectively. It is supposed that positive modulators act at multiple allosteric sites and that they interact with GYKI 53784 at only one of these sites. q</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14119000" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9ce31a5e5b42547ff3185519bce2f898" rel="nofollow" data-download="{"attachment_id":44585425,"asset_id":14119000,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44585425/download_file?st=MTczODU4Mzg1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33117487" href="https://independent.academia.edu/Istv%C3%A1nTarnawa">István Tarnawa</a><script data-card-contents-for-user="33117487" type="text/json">{"id":33117487,"first_name":"István","last_name":"Tarnawa","domain_name":"independent","page_name":"IstvánTarnawa","display_name":"István Tarnawa","profile_url":"https://independent.academia.edu/Istv%C3%A1nTarnawa?f_ri=65615","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14119000 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14119000"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14119000, container: ".js-paper-rank-work_14119000", }); 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The effects of various S -a-amino-3-hydroxy-5-methyl-4-izoxazole-propionate AMPA receptor modulators on AMPA-induced whole-cell currents were compared in isolated rat cerebellar Purkinje cells. The positive modulators, aniracetam, cyclothiazide, Ž . Ž . Ž . Ž . 1-1,3-benzodioxol-5-ylcarbonyl -piperidine 1-BCP , and 1-quinoxaline-6-ylcarbonyl -piperidine BDP-12 , dose-dependently potenti-Ž . Ž . ated the steady-state component of AMPA currents. The negative modulator, y 1-4-aminophenyl -4-methyl-7,8-methylenedioxy-4,5-di-Ž . hydro-3-methylcarbamoyl-2,3-benzodiazepine GYKI 53784 , dose-dependently suppressed AMPA responses. Its concentration-response curve was shifted to the right in a parallel fashion by all positive modulators, indicating a competitive type of interaction. However, the relative potencies of the positive modulators were different with regard to the enhancement of AMPA responses and the reversal of GYKI 53784-induced inhibition, respectively. It is supposed that positive modulators act at multiple allosteric sites and that they interact with GYKI 53784 at only one of these sites. q","downloadable_attachments":[{"id":44585425,"asset_id":14119000,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33117487,"first_name":"István","last_name":"Tarnawa","domain_name":"independent","page_name":"IstvánTarnawa","display_name":"István Tarnawa","profile_url":"https://independent.academia.edu/Istv%C3%A1nTarnawa?f_ri=65615","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":65615,"name":"Cerebellum","url":"https://www.academia.edu/Documents/in/Cerebellum?f_ri=65615","nofollow":true},{"id":133351,"name":"Benzodiazepines","url":"https://www.academia.edu/Documents/in/Benzodiazepines?f_ri=65615","nofollow":true},{"id":234860,"name":"Steady state","url":"https://www.academia.edu/Documents/in/Steady_state?f_ri=65615","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=65615","nofollow":true},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=65615"},{"id":612554,"name":"Purkinje Cells","url":"https://www.academia.edu/Documents/in/Purkinje_Cells?f_ri=65615"},{"id":1880638,"name":"Piperidines","url":"https://www.academia.edu/Documents/in/Piperidines?f_ri=65615"},{"id":1959400,"name":"Purkinje cell","url":"https://www.academia.edu/Documents/in/Purkinje_cell?f_ri=65615"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15553718 coauthored" data-work_id="15553718" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15553718/Speech_problems_affect_more_than_one_in_two_children_with_cerebral_palsy_Swedish_population_based_study">Speech problems affect more than one in two children with cerebral palsy: Swedish population-based study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Aim: To describe speech ability in a population-based study of children with cerebral palsy (CP), in relation to CP subtype, motor function, cognitive level and neuroimaging findings.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15553718" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="313cf7ea8033e3e2b73148f8a325bc3e" rel="nofollow" data-download="{"attachment_id":43090234,"asset_id":15553718,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43090234/download_file?st=MTczODU4Mzg1Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34798384" href="https://independent.academia.edu/ANordberg">A. 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