LDN 193189 in solution (8150) by Tocris, Part of Bio-Techne

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class="top_region"><div class="mb-2 o___product-summary"><div id="pp-page-title-brand-wrapper"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> LDN 193189 in solution </h1> <h2 class="font-weight-normal h4"> Tocris Bioscience, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">8150</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div class="col-auto d-flex align-self-center"> <div> <a href="#product-documents" class="datasheet_link product-documents" rel="nofollow">COA / SDS</a> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-tocris.svg" alt="Tocris Bioscience, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> </div> <div id="product_alerts_wrapper"><article class="product-data-wrapper"> </article> </div> </div> <div class="row border-top mb-2" id="images_atc_orderinfo_wrapper"><div class="col-xl-9 mt-2" id="image_atc_keydetails_wrapper"><div class="row" id="image_atc_wrapper"><div class="col-xl-4 order-xl-first" id="image_wrapper"><article class="product-data-wrapper"> <div class="image-slider-container"> <div class="product-image-lightbox tocris-image" data-brand="tocris"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="https://resources.bio-techne.com/images/products/structures/ldn-193189-in-solution_8150.png" alt="Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water" title="LDN 193189 in solution | CAS No. 1435934-00-1" data-caption="Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water" data-badges="" data-application="N/A" width="250" height="250" fetchpriority=high as=image class="search_result_thumbnail_image" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </article> </div> <div class="col-xl-8" id="atc_wrapper"><article class="product-data-wrapper"> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="8150"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-3 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart" class="atc-lines"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="8150/6" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">8150/6</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> <div class="atc-control ProductCart-control text-right"> <div class="row container d-flex justify-content-end mx-0 mb-3 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="" class="atc-print-quote-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100">Print Quote</a> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=8150" class="atc-bulk-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </article> </div> </div> <div class="row datapoint_list border-top" id="key_details_wrapper"><div class="col-xl-12 mt-2" id="key_details_col_wrapper"></div> </div> </div> <div class="col-xl-3 mt-2" id="orderinfo_guarantee_wrapper"><div id="order_information_wrapper"><div id="product_shipping_block_wrapper" data-brand="tocris" data-shipping="" data-source="ep-data" data-sub_category_id="103"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"><span class="sr-only">Loading...</span></div> </div> </div> <div id="video-tile-wrapper"><article class="product-data-wrapper"> <div class="video_tile_wrapper"> <article> <div> <lite-youtube videoid="J-YqGoL3m_c" style="background-image: url('https://resources.tocris.com/images/webinars/about-tocris-video.jpg');"> <a href="https://www.youtube.com/embed/J-YqGoL3m_c?autoplay=1" class="lty-playbtn" title="Introduction to Tocris"> <span class="lyt-visually-hidden">Introduction to Tocris</span> </a> </lite-youtube> </div> </article> </div> </article> </div> <div id="product_ads_wrapper"><article class="product-data-wrapper"> </article> </div> </div> </div> <div class="datapoint_list" id="key_details"><h3>Key Product Details</h3><table class=" table" id="key_details_table_wrapper"><tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Description: </td> <td class="product-data-value py-2 align-top w-75 text-break"> Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Chemical Name: </td> <td class="product-data-value py-2 align-top w-75 text-break"> 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-<em>a</em>]pyrimidin-3-yl]quinoline dihydrochloride </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Purity: </td> <td class="product-data-value py-2 align-top w-75 text-break"> ≥97% (HPLC) </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Molecular Weight: </td> <td class="product-data-value py-2 align-top w-75 text-break"> 479.41 </td> </tr> </table> </div> <div id="view_technical_detail_links"><div class="text-center"> <a id="view_technical" href="#technical-data-tab-tab">View Full Technical Details for LDN 193189 in solution</a> </div> </div> </div> <div class="tab-content"><div id="about-data-tab-tab"></div> <ul class="nav nav-tabs nav-fill " id="productTab" role="tablist"> <li class="nav-item"> <a class="nav-link active" id="technical-data-tab-tab" href="#technical-data-tab" data-toggle="tab" role="tab" aria-controls="region-2411584697015" aria-selected="true" >Technical Data</a> </li> <li class="nav-item"> <a class="nav-link" id="citations-tab-tab" href="#citations-tab" data-toggle="tab" role="tab" aria-controls="region-8061584697120" aria-selected="false" >Citations</a> </li> </ul> <div class="tab-content rounded-bottom border-left border-right border-bottom mb-3" id="ProductTabContent"><div class="tab-pane fade show active mx-4" id="technical-data-tab" data-tab-label="Technical Data" role="tabpanel" aria-labelledby="technical-data-tab-tab"><div class="product_details_anchors"><div class="product-pages-anchors nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"><li id="biological-activity_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor active" href="#biological-activity" id="biological-activity_li" >Biological Activity</a> </li> <li id="spectra-viewer_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#spectra-viewer" id="spectra-viewer_li" >Spectra Viewer</a> </li> <li id="technical-data_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#technical-data" id="technical-data_li" >Technical Data</a> </li> <li id="solubility_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#solubility" id="solubility_li" >Solubility</a> </li> <li id="calculators_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#calculators" id="calculators_li" >Calculators</a> </li> <li id="references_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#references" id="references_li" >References</a> </li> <li id="product-documents_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 product-documents datasheet_static_link" href="#product-documents" id="product-documents_li" >Product Datasheets</a> </li> </div> <div id="biological-activity" class="nav-link px-0" data-anchor-label="Biological Activity"><div id="biological_activity_wrapper"><h3>Biological Activity for LDN 193189 in solution</h3><div class="product-data-wrapper"> <p> LDN 193189 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of <a href="/p/small-molecules-peptides/ldn-193189-dihydrochloride_6053" target="_self">LDN 193189</a> pre-dissolved in water. A potent and selective ALK2 and ALK3 inhibitor (IC<sub>50</sub> values are 5 nM and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Promotes neural induction of hPSCs in combination with <a href="/p/small-molecules-peptides/sb-431542_1614" target="_self">SB 431542</a> (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with <a href="/p/small-molecules-peptides/sb-431542_1614" target="_self">SB 431542</a> (Cat. No. 1614), <a href="/p/small-molecules-peptides/su-5402_3300" target="_self">SU 5402</a> (Cat. No. 3300), <a href="/p/small-molecules-peptides/chir-99021_4423" target="_self">CHIR 99021</a> (Cat. No. 4423) and <a href="/p/small-molecules-peptides/dapt_2634" target="_self">DAPT</a> (Cat. No. 2634). </p> </div> </div> <div id="licensing_caveat_wrapper"><h3>Licensing Information</h3><div class="product-data-wrapper"> <p> Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patents 8,507,501 and 9,045,484 </p> </div> </div> </div> <div id="spectra-viewer" class="nav-link px-0" data-anchor-label="Spectra Viewer"></div> <div id="technical-data" class="nav-link px-0" data-anchor-label="Technical Data"><div id="technical_data_wrapper"><h3>Technical Data for LDN 193189 in solution</h3><table class="tablesaw tablesaw-stack table-bordered table" id="technical_data_product-data-wrapper"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">M. Wt</td> <td class="product-data-value p-3 px-4 text-break"> 479.41 </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Formula</td> <td class="product-data-value p-3 px-4 text-break"> C<sub>25</sub>H<sub>22</sub>N<sub>6</sub>.2HCl </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Storage</td> <td class="product-data-value p-3 px-4 text-break"> Store at -20°C </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Purity</td> <td class="product-data-value p-3 px-4 text-break"> ≥97% (HPLC) </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">CAS Number</td> <td class="product-data-value p-3 px-4 text-break"> 1435934-00-1 </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">InChi Key</td> <td class="product-data-value p-3 px-4 text-break"> CMQXLLAILGGLRV-UHFFFAOYSA-N </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Smiles</td> <td class="product-data-value p-3 px-4 text-break"> N1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl </td> </tr> </table> <p class="small">The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.</p> <p class="small">Tocris products are intended for laboratory research use only, unless stated otherwise.</p> </div> </div> <div id="solubility" class="nav-link px-0" data-anchor-label="Solubility"><div id="solubility"><h3>Solubility for LDN 193189 in solution</h3> <table class="tablesaw tablesaw-stack table-bordered"> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Solubility</td> <td class="product-data-value p-3 px-4 text-break"> Soluble in water (supplied pre-dissolved at a concentration of 10mM) </td> </tr> </table> </div> </div> <div id="calculators" class="nav-link px-0" data-anchor-label="Calculators"><div class="calculator card p-3" id="molarity_calculator_wrapper"><h3>Molarity Calculator</h3><article class="product-data-wrapper"> <div class="product-calculator"> <p>Calculate the mass, volume, or concentration required for a solution.</p> <form id="molarity-calculator" class="calculator-wrapper"> <div class="form-inline"> <div class="calc_section"> <label>Mass</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-mass js-form-item-molarity-calculator-mass"> <input id="molarity_calculator_mass" class="calculator_input calculator_text form-control form-text" placeholder="mass" type="text" name="molarity_calculator_mass" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-molarity-calculator-mass-unit js-form-item-molarity-calculator-mass-unit"> <select id="molarity_calculator_mass_unit" class="calculator_select custom-select form-select" name="molarity_calculator_mass_unit"> <option value="-12">pg</option> <option value="-9">ng</option> <option value="-6">µg</option> <option value="-3" selected="selected">mg</option> <option value="0">g</option> <option value="3">kg</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_equals calculator_operator mx-2 position-relative">=</div> <div class="calc_section"> <label>Concentration</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-concentration js-form-item-molarity-calculator-concentration"> <input id="molarity_calculator_concentration" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="molarity_calculator_concentration" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-molarity-calculator-concentration-unit js-form-item-molarity-calculator-concentration-unit"> <select id="molarity_calculator_concentration_unit" class="calculator_select custom-select form-select" name="molarity_calculator_concentration_unit"> <option value="-15">fM</option> <option value="-12">pM</option> <option value="-9">nM</option> <option value="-6">µM</option> <option value="-3" selected="selected">mM</option> <option value="0">M</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>Volume</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-volume js-form-item-molarity-calculator-volume"> <input id="molarity_calculator_volume" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="molarity_calculator_volume" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-molarity-calculator-volume-unit js-form-item-molarity-calculator-volume-unit"> <select id="molarity_calculator_volume_unit" class="calculator_select custom-select form-select" name="molarity_calculator_volume_unit"> <option value="-9">nL</option> <option value="-6">µL</option> <option value="-3" selected="selected">mL</option> <option value="0">L</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>M. Wt*</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-molecular-weight js-form-item-molarity-calculator-molecular-weight"> <input id="molarity_calculator_molecular_weight" placeholder="mwt" class="calculator_input calculator_text form-control form-text" type="text" name="molarity_calculator_molecular_weight" value="479.41" size="10" maxlength="6"> </div> </div> </fieldset> <div class="calculator_operator mx-2 position-relative"> g/mol </div> </div> </div> </div> <div class="alert alert-danger calculator-error d-none" role="alert"></div> <div class="calculator_footer"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <input id="button_molarity_calculator_calculate" class="calculator_button btn btn-primary button js-form-submit form-submit" type="submit" name="op" value="Calculate"> </div> </fieldset> </div> <div class="calculator_disclaimer"> <p>*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).</p> </div> </form> </div> </article> </div> <div class="calculator card p-3" id="dilution_calculator_wrapper"><h3>Dilution Calculator</h3><article class="product-data-wrapper"> <div class="product-calculator"> <p>Calculate the dilution required to prepare a stock solution.</p> <form id="dilution-calculator" class="calculator-wrapper"> <div class="form-inline"> <div class="calc_section"> <label>Concentration 1 (C1)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-concentration js-form-item-dilution-calculator-concentration"> <input id="dilution_calculator_concentration" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_concentration" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-concentration-unit js-form-item-dilution-calculator-concentration-unit"> <select id="dilution_calculator_concentration_unit" class="calculator_select custom-select form-select" name="dilution_calculator_concentration_unit"> <option value="fM">fM</option> <option value="pM">pM</option> <option value="nM">nM</option> <option value="uM">µM</option> <option value="mM" selected="selected">mM</option> <option value="M">M</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>Volume 1 (V1)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-volume js-form-item-dilution-calculator-volume"> <input id="dilution_calculator_volume" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_volume" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-volume-unit js-form-item-dilution-calculator-volume-unit"> <select id="dilution_calculator_volume_unit" class="calculator_select custom-select form-select" name="dilution_calculator_volume_unit"> <option value="nl">nL</option> <option value="ul">µL</option> <option value="ml" selected="selected">mL</option> <option value="l">L</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_equals calculator_operator mx-2 position-relative">=</div> <div class="calc_section"> <label>Concentration 2 (C2)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-concentration2 js-form-item-dilution-calculator-concentration2"> <input id="dilution_calculator_concentration2" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_concentration2" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-concentration2-unit js-form-item-dilution-calculator-concentration2-unit"> <select id="dilution_calculator_concentration2_unit" class="calculator_select custom-select form-select" name="dilution_calculator_concentration2_unit"> <option value="fM">fM</option> <option value="pM">pM</option> <option value="nM">nM</option> <option value="uM">µM</option> <option value="mM" selected="selected">mM</option> <option value="M">M</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>Volume 2 (V2)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-volume2 js-form-item-dilution-calculator-volume2"> <input id="dilution_calculator_volume2" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_volume2" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-volume2-unit js-form-item-dilution-calculator-volume2-unit"> <select id="dilution_calculator_volume2_unit" class="calculator_select custom-select form-select" name="dilution_calculator_volume2_unit"> <option value="nl">nL</option> <option value="ul">µL</option> <option value="ml" selected="selected">mL</option> <option value="l">L</option> </select> </div> </div> </fieldset> </div> </div> </div> <div class="alert alert-danger calculator-error d-none" role="alert"></div> <div class="calculator_footer"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <input id="button_dilution_calculator_calculate" class="calculator_button btn btn-primary button js-form-submit form-submit" type="submit" name="op" value="Calculate"> </div> </fieldset> </div> </form> </div> </article> </div> <div class="calculator card p-3" id="reconstitution_calculator_wrapper"><h3>Reconstitution Calculator</h3><article class="product-data-wrapper"> <div class="product-calculator"> <form id="reconstitution-calculator" class="calculator-wrapper"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> <div class="form-inline"> <div class="calc_section"> <label>Volume (to add to vial)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-textfield form-item-reconstitution-calculator-volume js-form-item-reconstitution-calculator-volume"> <input id="reconstitution_calculator_volume" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="reconstitution_calculator_volume" value="" size="10" maxlength="6"> </div> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-select form-item-reconstitution-calculator-volume-unit js-form-item-reconstitution-calculator-volume-unit"> <select id="reconstitution_calculator_volume_unit" class="calculator_select custom-select form-select" name="reconstitution_calculator_volume_unit"> <option value="ml">ml</option> <option value="ul" selected="selected">µl</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_equals calculator_operator mx-2 position-relative">=</div> <div class="calc_section"> <label>Mass (in vial)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-textfield form-item-reconstitution-calculator-mass js-form-item-reconstitution-calculator-mass"> <input id="reconstitution_calculator_mass" class="calculator_input calculator_text form-control form-text" placeholder="mass" type="text" name="reconstitution_calculator_mass" value="" size="10" maxlength="6"> </div> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-select form-item-reconstitution-calculator-mass-unit js-form-item-reconstitution-calculator-mass-unit"> <select id="reconstitution_calculator_mass_unit" class="calculator_select custom-select form-select" name="reconstitution_calculator_mass_unit"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_divide_by calculator_operator mx-2 position-relative">÷</div> <div class="calc_section"> <div> <label>Desired Reconstitution Concentration</label> </div> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-textfield form-item-reconstitution-calculator-concentration js-form-item-reconstitution-calculator-concentration"> <input id="reconstitution_calculator_concentration" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="reconstitution_calculator_concentration" value="" size="10" maxlength="6"> </div> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-select form-item-reconstitution-calculator-concentration-unit js-form-item-reconstitution-calculator-concentration-unit"> <select id="reconstitution_calculator_concentration_unit" class="calculator_select custom-select form-select" name="reconstitution_calculator_concentration_unit"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">µg/ml</option> <option value="ng/ml">ng/ml</option> </select> </div> </div> </fieldset> </div> </div> </div> <div class="alert alert-danger calculator-error d-none" role="alert"></div> <div class="calculator_footer"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <input id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-primary button js-form-submit form-submit" type="submit" name="op" value="Calculate"> </div> </fieldset> </div> </form> </div> </article> </div> </div> <div id="references" class="nav-link px-0" data-anchor-label="References"> <div id="references"> <h3>References for LDN 193189 in solution</h3> <p>References are publications that support the biological activity of the product.</p> <ul> <li> <strong>Lancaster</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/25188634" target="_blank" rel="nofollow">Generation of cerebral organoids from human pluripotent stem cells.</a> Nat.Protoc. 2015 PMID: 25188634 </li> <li> <strong>Li</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/24012368" target="_blank" rel="nofollow">Chemical approaches to stem cell biology and therapeutics.</a> Cell Stem Cell 2013 PMID: 24012368 </li> <li> <strong>Chambers</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/22750882" target="_blank" rel="nofollow">Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.</a> Nat.Biotechnol. 2012 PMID: 22750882 </li> <li> <strong>Cuny</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/18621530" target="_blank" rel="nofollow">Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.</a> Bioorg.Med.Chem.Lett. 2008 PMID: 18621530 </li> <li> <strong>Yu</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/19029982" target="_blank" rel="nofollow">BMP type I receptor inhibition reduces heterotopic ossification.</a> Nat.Med. 2008 PMID: 19029982 </li> </ul> </div> </div> <div id="product-datasheets-anchor" class="nav-link static-anchor p-0" data-anchor-label="Product Datasheets"></div> </div> </div> <div class="tab-pane fade mx-4 py-4" id="citations-tab" data-tab-label="Citations" role="tabpanel" aria-labelledby="citations-tab-tab"><div class="product_details_anchors mb-2"> <div class="nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#citations"> Citations </a> </li> </div> </div> <div id="citations"> <section id="citations-tab-content-placeholder" class="tab-content-placeholder" data-id="citations" data-product_code="8150"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> </div> </div> </div> </div> <div id="product-documents"> <div id="datasheet-accordion" class="accordion border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3">Product Documents for LDN 193189 in solution</h3> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse show " aria-labelledby="heading_one" data-parent="#datasheet-accordion"> <div class="card-body"> Certificate of Analysis is currently unavailable on-line. 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LDN 193189 in solution (8150) by Tocris, Part of Bio-Techne