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Custom Targeted Protein Degradation Services | Bio-Techne

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Our expert chemistry team is highly experienced in Degrader synthesis and can develop building blocks from different <a href="/search?keywords=e3%20ligase%20inhibitors&amp;category_attr=Small%20Molecules%20and%20Peptides">E3 ligase ligands</a> and linkers of your choosing, not currently available off-the-shelf.</p></div> </div> <div class="card-bottom-link"> <div> <a href="#inquire" > Contact our Expert Chemistry Team </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-6"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/protac-panel-builder" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/small-moleculeslight-blue.png" alt="small molecule icon" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="https://www.tocris.com/protac-panel-builder" > <h3 class="card_title_htag"> <div><h3>PROTAC® Panel Builder</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our PROTAC<sup>®</sup>&nbsp;Panel Builder online tool allows you to rapidly generate a unique collection of functionalized E3 ligase ligands plus linkers of your choosing. Select any combination of E3 ligase ligand targeting Cereblon, VHL or IAP, with PEG or alkyl linker, and functional group to couple to your target ligand and we will send you a quote. Degrader development has never been easier!</p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/protac-panel-builder" > Explore Panel Builder Tool </a> </div> </div> </div> </div> </div> <div class="col-md-6"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/services/custom-protein-services" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/proteins-icon-light-2.png" alt="Representation of a protein" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/services/custom-protein-services" > <h3 class="card_title_htag"> <div><h3>Custom E3 Ligases</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our Proteins Group provides superior quality Ubiquitin-Proteasome System Proteins/E3 Ligases enabling you to develop assays to investigate the activity of your Degraders on ubiquitination of substrate proteins. 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