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</div> </div> </div> </div> <div id="content-contain"> <div id="primary" class="content-area"> <main id="main" class="site-main" role="main"> <article id="post-7" class="post-7 page type-page status-publish hentry"> <div class="entry-content"> <div class="blocks-content"> <div class="kb-row-layout-wrap kb-row-layout-id7_18e14b-09 alignwide wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column7_63c273-fe inner-column-1"><div class="kt-inside-inner-col"> <h1 class="wp-block-heading has-text-align-center" style="font-size:1.875rem">Accelerate Your Small Molecule Drug Discovery With X-Chem</h1> </div></div> </div></div> <div class="kb-row-layout-wrap kb-row-layout-id7_4e723a-a9 alignwide wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row 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<div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> SARS-CoV-2, Mpro IC<sub>50</sub>= 6 nM, antiviral EC<sub>50</sub> 33 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Antiviral </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=24856#track-records" class="trecord trecord-link type-protein"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Protein Protein Interaction</span></div> <div class="tr-img"> <svg id="Layer_1" data-name="Layer 1" width="250" height="160" viewBox="0 0 284.298330223929042 243.604846747355623"> <path 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<path d="M46.123140810902441,190.33544921875c-1.48388671875,0-2.68701171875-1.203125-2.68701171875-2.6875v-21.4580078125c0-1.484375,1.203125-2.6875,2.68701171875-2.6875s2.68701171875,1.203125,2.68701171875,2.6875v21.4580078125c0,1.484375-1.203125,2.6875-2.68701171875,2.6875Z" fill="#555861" stroke-width="0"/> <path d="M243.574312685902441,55.77490234375c-1.484375,0-2.6875-1.203125-2.6875-2.68701171875v-23.796875c0-1.48388671875,1.203125-2.68701171875,2.6875-2.68701171875s2.6875,1.203125,2.6875,2.68701171875v23.796875c0,1.48388671875-1.203125,2.68701171875-2.6875,2.68701171875Z" fill="#555861" stroke-width="0"/> <path 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d="M44.29,126.98v-2.66c0-1.82.84-2.97,2.82-2.97h3.06c1.98,0,2.82,1.14,2.82,2.97v2.66c0,1.81-.85,2.96-2.82,2.96h-3.06c-1.98,0-2.82-1.14-2.82-2.96ZM50.17,128.31c.8,0,1.17-.23,1.17-1.28v-2.79c0-1.06-.33-1.29-1.17-1.29h-3.06c-.82,0-1.17.23-1.17,1.29v2.79c0,1.05.37,1.28,1.17,1.28h3.06Z" fill="#0868b1" stroke-width="0"/> <path d="M15.08,70.78v-2.66c0-1.82.84-2.97,2.82-2.97h3.06c1.98,0,2.82,1.14,2.82,2.97v2.66c0,1.81-.85,2.96-2.82,2.96h-3.06c-1.98,0-2.82-1.14-2.82-2.96ZM20.96,72.11c.8,0,1.17-.23,1.17-1.28v-2.79c0-1.06-.33-1.29-1.17-1.29h-3.06c-.82,0-1.17.23-1.17,1.29v2.79c0,1.05.37,1.28,1.17,1.28h3.06Z" fill="#0868b1" stroke-width="0"/> </svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> Pks13, MIC = 250 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Infectious Disease </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=24650#track-records" class="trecord trecord-link type-protein"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Protein Protein Interaction</span></div> <div class="tr-img"> <svg width="250" height="160" viewBox="0 0 250 160" aria-hidden="true"> <path d="M36.48,141.56c-.1,0-.21-.01-.31-.04-.73-.17-1.19-.9-1.02-1.63l2.95-12.63c.17-.73.9-1.19,1.63-1.02.73.17,1.19.9,1.02,1.63l-2.95,12.63c-.15.63-.71,1.05-1.32,1.05Z" fill="#121a22" stroke-width="0"/> <path d="M15.65,119.99c-.63,0-1.2-.44-1.33-1.09-.15-.74.33-1.45,1.06-1.6l12.62-2.57c.74-.15,1.45.33,1.6,1.06.15.74-.33,1.45-1.06,1.6l-12.62,2.57c-.09.02-.18.03-.27.03Z" fill="#121a22" stroke-width="0"/> <polygon points="95.95 82.67 88.8 91.34 86.04 87.96 94.81 81.86 95.95 82.67" fill="#121a22" stroke-width="0"/> <path d="M63.44,91.93c-.28,0-.53-.19-.59-.47l-2.62-11.13c-.08-.33.13-.65.45-.73.33-.08.65.13.73.45l2.62,11.13c.08.33-.13.65-.45.73-.05.01-.09.02-.14.02Z" 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d="M120.57,84.29v-8.2c0-.2.11-.31.31-.31h1.09c.2,0,.31.11.31.31v3.31h4.64v-3.31c0-.2.11-.31.31-.31h1.1c.2,0,.31.11.31.31v8.2c0,.2-.11.31-.31.31h-1.1c-.2,0-.31-.11-.31-.31v-3.35h-4.64v3.35c0,.2-.11.31-.31.31h-1.09c-.2,0-.31-.11-.31-.31Z" fill="#121a22" stroke-width="0"/> <path d="M120.57,94.79v-8.2c0-.2.11-.31.31-.31h1.1c.16,0,.28.06.38.19l4.75,6.02v-5.9c0-.2.11-.31.31-.31h1.09c.2,0,.31.11.31.31v8.2c0,.2-.11.31-.31.31h-1.1c-.16,0-.28-.06-.38-.19l-4.75-5.99v5.86c0,.2-.11.31-.31.31h-1.09c-.2,0-.31-.11-.31-.31Z" fill="#121a22" stroke-width="0"/> <path d="M77.73,98.42v-8.2c0-.2.11-.31.31-.31h1.1c.16,0,.28.06.38.19l4.75,6.02v-5.9c0-.2.11-.31.31-.31h1.09c.2,0,.31.11.31.31v8.2c0,.2-.11.31-.31.31h-1.1c-.16,0-.28-.06-.38-.19l-4.75-5.99v5.86c0,.2-.11.31-.31.31h-1.09c-.2,0-.31-.11-.31-.31Z" fill="#121a22" stroke-width="0"/> <path d="M77.73,108.92v-8.2c0-.2.11-.31.31-.31h1.09c.2,0,.31.11.31.31v3.31h4.64v-3.31c0-.2.11-.31.31-.31h1.1c.2,0,.31.11.31.31v8.2c0,.2-.11.31-.31.31h-1.1c-.2,0-.31-.11-.31-.31v-3.35h-4.64v3.35c0,.2-.11.31-.31.31h-1.09c-.2,0-.31-.11-.31-.31Z" fill="#121a22" stroke-width="0"/> </svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> IL-17A, HeLa IC<sub>50</sub> = 5 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Inflammation </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=24425#track-records" class="trecord trecord-link type-protein"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Protein Protein Interaction</span></div> <div class="tr-img"> <svg aria-hidden="true" width="250" height="160" viewBox="0 0 250 160"> <path 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fill="#555861" stroke-width="0"/> <path d="M23.34,81.44c-.3,0-.6-.16-.76-.44-.24-.42-.1-.96.32-1.2l9.08-5.22c.42-.24.96-.1,1.2.32.24.42.1.96-.32,1.2l-9.08,5.22c-.14.08-.29.12-.44.12ZM155.15,114.72c.43-.23.59-.76.36-1.19l-3-5.58c-.23-.43-.76-.59-1.19-.36-.43.23-.59.76-.36,1.19l3,5.58c.16.29.46.46.77.46.14,0,.28-.03.41-.11Z" fill="#555861" stroke-width="0"/> </svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> Mcl-1, IC<sub>50</sub> = 31 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=24195#track-records" class="trecord trecord-link type-receptors"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Receptors</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" aria-hidden="true" width="250" 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3.4-3.24 3.4h-3.05c-2.27 0-3.24-1.31-3.24-3.4v-3.06c0-2.1.97-3.41 3.24-3.41h3.05c2.27 0 3.24 1.31 3.24 3.41Zm3.42-3.8v9.91c0 .22-.12.35-.34.35h-1.12c-.22 0-.34-.13-.34-.35v-9.91c0-.22.12-.35.34-.35h1.12c.22 0 .34.13.34.35ZM128.48 89h-3.51c-2.27 0-3.24 1.31-3.24 3.41v3.06c0 2.08.97 3.4 3.24 3.4h3.51c2.27 0 3.24-1.31 3.24-3.4v-3.06c0-2.1-.97-3.41-3.24-3.41Zm1.34 6.54c0 1.2-.42 1.47-1.34 1.47h-3.51c-.92 0-1.34-.27-1.34-1.47v-3.2c0-1.22.4-1.48 1.34-1.48h3.51c.96 0 1.34.27 1.34 1.48v3.2ZM69.08 83.6v-9.17c0-.22.12-.35.34-.35h1.22c.22 0 .34.13.34.35v3.7h5.18v-3.7c0-.22.12-.35.34-.35h1.23c.22 0 .34.13.34.35v9.17c0 .22-.12.35-.34.35H76.5c-.22 0-.34-.13-.34-.35v-3.74h-5.18v3.74c0 .22-.12.35-.34.35h-1.22c-.22 0-.34-.13-.34-.35Zm20.16-9.17v9.17c0 .22-.12.35-.34.35h-1.23c-.18 0-.31-.07-.42-.21l-5.3-6.69v6.55c0 .22-.12.35-.34.35h-1.22c-.22 0-.34-.13-.34-.35v-9.17c0-.22.12-.35.34-.35h1.23c.18 0 .31.07.42.21l5.3 6.74v-6.6c0-.22.12-.35.34-.35h1.22c.22 0 .34.13.34.35Zm125.81-29.65h-3.51c-2.27 0-3.24 1.31-3.24 3.41v3.06c0 2.08.97 3.4 3.24 3.4h3.51c2.27 0 3.24-1.31 3.24-3.4v-3.06c0-2.1-.97-3.41-3.24-3.41Zm1.34 6.54c0 1.2-.42 1.47-1.34 1.47h-3.51c-.92 0-1.34-.27-1.34-1.47v-3.2c0-1.22.4-1.48 1.34-1.48h3.51c.96 0 1.34.27 1.34 1.48v3.2Zm12.7-6.19v9.17c0 .22-.12.35-.34.35h-1.23c-.22 0-.34-.13-.34-.35v-3.74H222v3.74c0 .22-.12.35-.34.35h-1.22c-.22 0-.34-.13-.34-.35v-9.17c0-.22.12-.35.34-.35h1.22c.22 0 .34.13.34.35v3.7h5.18v-3.7c0-.22.12-.35.34-.35h1.23c.22 0 .34.13.34.35Zm-60.04-9.71v9.17c0 .22-.12.35-.34.35h-1.23c-.18 0-.31-.07-.42-.21l-5.3-6.69v6.55c0 .22-.12.35-.34.35h-1.22c-.22 0-.34-.13-.34-.35v-9.17c0-.22.12-.35.34-.35h1.23c.18 0 .31.07.42.21l5.3 6.74v-6.6c0-.22.12-.35.34-.35h1.22c.22 0 .34.13.34.35Z"/><path fill="#545860" d="m154.96 41.44-10.54 2.96c-.06.02-.11.04-.16.06l-11.92-12.4c-.39-.4-.97-.56-1.51-.41l-18.24 5.12c-.53.15-.93.57-1.07 1.1l-4.47 18.21-16.91 4.75c-.53.15-.93.57-1.07 1.1l-1.65 6.71c-.2.82.3 1.64 1.11 1.84.12.03.24.04.36.04.68 0 1.3-.46 1.47-1.16l1.44-5.85 16.43-4.61 12.27 11.84c.29.28.67.43 1.06.43.14 0 .28-.02.41-.06l17.49-4.91c.53-.15.93-.57 1.07-1.1l4.35-17.73c.12 0 .24-.02.36-.05l10.54-2.96c.81-.23 1.28-1.07 1.05-1.87a1.51 1.51 0 0 0-1.87-1.05Zm-17.17 22.08-15.8 4.44-11.83-11.41s-.04-.09-.07-.13l4.16-16.95 16.51-4.64 11.2 11.66-4.18 17.04Zm57.44-20.23-16.4 10.95c-.26.17-.55.26-.84.26-.36 0-.71-.12-.99-.37l-5.85-5.05a1.51 1.51 0 0 1-.16-2.14 1.51 1.51 0 0 1 2.14-.16l4.98 4.29 14.49-9.67-5.11-16.22-16.71-.24-1.73 5.71c-.24.8-1.09 1.26-1.9 1.01-.8-.24-1.26-1.09-1.01-1.9l2.06-6.8c.2-.65.79-1.09 1.48-1.08l18.95.27c.66 0 1.23.44 1.43 1.06l5.78 18.36c.2.64-.04 1.35-.61 1.72ZM118.3 99.74l-5.5 5.5-11.54-11.54 11.54-11.54 5.3 5.3c.59.59 1.56.59 2.15 0 .59-.59.59-1.56 0-2.15l-6.37-6.37c-.57-.57-1.58-.57-2.15 0L99.09 91.58l-5.1-4.92c-.6-.58-1.57-.57-2.15.04-.58.6-.57 1.57.04 2.15l4.72 4.56-13.63 8.45-16.17-8.78c-.46-.25-1.01-.25-1.47 0l-15.64 8.73c-.49.27-.79.79-.78 1.35l.31 18.09-11.84 7.46c-.71.45-.92 1.39-.48 2.1.29.46.78.71 1.29.71.28 0 .56-.08.81-.23l11.81-7.44 16.15 8.77c.23.12.48.18.73.18.27 0 .55-.07.79-.22l15.63-9.51c.46-.28.74-.78.73-1.32l-.3-17.28 14.3-8.86 12.88 12.88a1.507 1.507 0 0 0 2.15 0l6.57-6.57c.59-.59.59-1.56 0-2.15s-1.56-.59-2.15 0Zm-50.65 29.78-15.38-8.35-.29-17.15 14.12-7.88 15.42 8.37.28 16.41-14.14 8.6Z"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> WDR91, K<sub>d</sub> = 6µM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Virology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=23059#track-records" class="trecord trecord-link type-protein"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Protein Protein Interaction</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>DCAF1, SPR KD = 38 nM</title><path fill="#121a22" d="M138.56 64.25h-4.31a.591.591 0 0 1 0-1.18h4.31a.591.591 0 0 1 0 1.18Zm.12 2.94c0-.33-.26-.59-.59-.59h-3.34a.591.591 0 0 0 0 1.18h3.34c.32 0 .59-.26.59-.59Zm-.47 3.53c0-.33-.26-.59-.59-.59h-2.38a.591.591 0 0 0 0 1.18h2.38c.32 0 .59-.26.59-.59Zm-.47 3.53c0-.33-.26-.59-.59-.59h-1.41a.591.591 0 0 0 0 1.18h1.41c.32 0 .59-.26.59-.59Zm-37.04 56.62 3.37-11.99a.59.59 0 0 0-.41-.73.59.59 0 0 0-.73.41l-3.37 11.99a.59.59 0 0 0 .57.75c.26 0 .49-.17.57-.43Zm35.36-75.89a.59.59 0 0 1-.3-1.1l10.39-6.15a.59.59 0 1 1 .6 1.02l-10.39 6.15c-.09.06-.2.08-.3.08Zm11.1-17.86c.16-.28.06-.64-.22-.8l-11.11-6.33a.589.589 0 0 0-.8.22c-.16.28-.06.64.22.8l11.11 6.33c.09.05.19.08.29.08.2 0 .4-.11.51-.3Zm-21.02 12.76c.33 0 .58-.27.58-.6l-.17-12.46c0-.33-.27-.6-.6-.58-.33 0-.58.27-.58.6l.17 12.46c0 .32.27.58.59.58Zm38.71 29.51V66.93a.585.585 0 1 0-1.17 0v12.46a.585.585 0 1 0 1.17 0Zm3.46 0V66.93a.585.585 0 1 0-1.17 0v12.46a.585.585 0 1 0 1.17 0Zm-63.28 0V66.93a.585.585 0 1 0-1.17 0v12.46a.585.585 0 1 0 1.17 0Zm3.46 0V66.93a.585.585 0 1 0-1.17 0v12.46a.585.585 0 1 0 1.17 0Zm-.16 59.63 11.71-2.94c.32-.08.51-.4.43-.71a.584.584 0 0 0-.71-.43l-11.71 2.94c-.32.08-.51.4-.43.71.07.27.31.45.57.45.05 0 .1 0 .14-.02Zm15.41-13.98c.23-.23.24-.6.02-.83l-8.85-9.23a.595.595 0 0 0-.83-.02c-.23.23-.24.6-.02.83l8.85 9.23a.592.592 0 0 0 .83.02Zm10.68-112.73h1.04c.19 0 .3-.11.3-.3V8.73h3.19c.19 0 .3-.11.3-.3v-.88c0-.19-.11-.3-.3-.3h-3.19V5.39h4.95c.19 0 .3-.11.3-.3v-1c0-.19-.11-.3-.3-.3h-6.29c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm-58.2 128.12h1.04c.19 0 .3-.11.3-.3v-3.28h3.19c.19 0 .3-.11.3-.3v-.88c0-.19-.11-.3-.3-.3h-3.19v-1.86h4.95c.19 0 .3-.11.3-.3v-1.01c0-.19-.11-.3-.3-.3h-6.29c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3ZM66.07 110.7h1.05c.19 0 .3-.11.3-.3v-5.68l4.6 5.8c.09.12.21.18.37.18h1.07c.19 0 .3-.11.3-.3v-7.94c0-.19-.11-.3-.3-.3h-1.05c-.19 0-.3.11-.3.3v5.72l-4.6-5.84a.433.433 0 0 0-.37-.18h-1.07c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm111.8-20.55h1.05c.19 0 .3-.11.3-.3v-5.68l4.6 5.8c.09.12.21.18.37.18h1.07c.19 0 .3-.11.3-.3v-7.94c0-.19-.11-.3-.3-.3h-1.05c-.19 0-.3.11-.3.3v5.72l-4.6-5.84a.433.433 0 0 0-.37-.18h-1.07c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm9.69 0h1.05c.19 0 .3-.11.3-.3v-3.24h4.49v3.24c0 .19.11.3.3.3h1.07c.19 0 .3-.11.3-.3v-7.94c0-.19-.11-.3-.3-.3h-1.07c-.19 0-.3.11-.3.3v3.21h-4.49v-3.21c0-.19-.11-.3-.3-.3h-1.05c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm9.09 4.03h4.12c.11 0 .17-.06.17-.18v-.59c0-.11-.06-.18-.17-.18h-2.68l1.56-.95c.96-.58 1.31-.81 1.31-1.66 0-.91-.43-1.44-1.64-1.44h-1.21c-1.28 0-1.64.66-1.64 1.72v.1c0 .06.06.1.17.1h.61c.11 0 .17-.06.17-.18v-.06c0-.63.18-.75.68-.75h1.18c.54 0 .71.11.71.57 0 .33-.12.44-.65.76l-2.76 1.7c-.08.05-.12.12-.12.21v.63c0 .11.06.18.17.18Zm-78.91-4.03h1.05c.19 0 .3-.11.3-.3v-5.68l4.6 5.8c.09.12.21.18.37.18h1.07c.19 0 .3-.11.3-.3v-7.94c0-.19-.11-.3-.3-.3h-1.05c-.19 0-.3.11-.3.3v5.71l-4.6-5.84a.433.433 0 0 0-.37-.18h-1.07c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm.18 10.87h1.05c.19 0 .3-.11.3-.3v-3.24h4.49v3.24c0 .19.11.3.3.3h1.07c.19 0 .3-.11.3-.3v-7.94c0-.19-.11-.3-.3-.3h-1.07c-.19 0-.3.11-.3.3v3.21h-4.49v-3.21c0-.19-.11-.3-.3-.3h-1.05c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm-68.57-8.28h1.05c.19 0 .3-.11.3-.3V89.2h4.49v3.24c0 .19.11.3.3.3h1.07c.19 0 .3-.11.3-.3V84.5c0-.19-.11-.3-.3-.3h-1.07c-.19 0-.3.11-.3.3v3.21H50.7V84.5c0-.19-.11-.3-.3-.3h-1.05c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm9.51 0h1.05c.19 0 .3-.11.3-.3v-5.68l4.6 5.8c.09.12.21.18.37.18h1.07c.19 0 .3-.11.3-.3V84.5c0-.19-.11-.3-.3-.3H65.2c-.19 0-.3.11-.3.3v5.71l-4.6-5.84a.433.433 0 0 0-.37-.18h-1.07c-.19 0-.3.11-.3.3v7.94c0 .19.11.3.3.3Zm40.02-63.05h2.64c1.97 0 2.81-1.14 2.81-2.94v-.24c0-.15-.11-.23-.3-.23h-1.05c-.19 0-.3.11-.3.3v.23c0 1.04-.37 1.27-1.16 1.27h-2.64c-.79 0-1.16-.23-1.16-1.27v-2.77c0-1.05.34-1.28 1.16-1.28h2.64c.82 0 1.16.23 1.16 1.28v.19c0 .12.11.21.3.21h1.05c.19 0 .3-.11.3-.3v-.04c0-1.82-.84-2.95-2.81-2.95h-2.64c-1.97 0-2.81 1.14-2.81 2.95v2.65c0 1.8.84 2.94 2.81 2.94Zm7.16 0h.97c.19 0 .3-.11.3-.3v-8.58c0-.19-.11-.3-.3-.3h-.97c-.19 0-.3.11-.3.3v8.58c0 .19.11.3.3.3Zm30 126.59h2.64c1.97 0 2.81-1.14 2.81-2.94v-.24c0-.15-.11-.23-.3-.23h-1.05c-.19 0-.3.11-.3.3v.23c0 1.04-.37 1.27-1.16 1.27h-2.64c-.79 0-1.16-.23-1.16-1.27v-2.77c0-1.05.34-1.28 1.16-1.28h2.64c.82 0 1.16.23 1.16 1.28v.19c0 .12.11.21.3.21h1.05c.19 0 .3-.11.3-.3v-.04c0-1.82-.84-2.95-2.81-2.95h-2.64c-1.97 0-2.81 1.14-2.81 2.95v2.65c0 1.8.84 2.94 2.81 2.94Zm7.16 0h.97c.19 0 .3-.11.3-.3v-8.59c0-.19-.11-.3-.3-.3h-.97c-.19 0-.3.11-.3.3v8.59c0 .19.11.3.3.3Zm21.58-91.66h3.04c1.97 0 2.81-1.14 2.81-2.94v-2.65c0-1.82-.84-2.95-2.81-2.95h-3.04c-1.97 0-2.81 1.14-2.81 2.95v2.65c0 1.8.84 2.94 2.81 2.94Zm0-1.61c-.79 0-1.16-.23-1.16-1.27v-2.77c0-1.05.34-1.28 1.16-1.28h3.04c.83 0 1.16.23 1.16 1.28v2.77c0 1.04-.37 1.27-1.16 1.27h-3.04Zm-59.98 1.66h3.04c1.97 0 2.81-1.14 2.81-2.94v-2.65c0-1.82-.84-2.95-2.81-2.95h-3.04c-1.97 0-2.81 1.14-2.81 2.95v2.65c0 1.8.84 2.94 2.81 2.94Zm0-1.61c-.79 0-1.16-.23-1.16-1.27v-2.77c0-1.05.34-1.28 1.16-1.28h3.04c.83 0 1.16.23 1.16 1.28v2.77c0 1.04-.37 1.27-1.16 1.27h-3.04Zm-29.17 38.49 9.9-1.15a.6.6 0 0 0 .52-.65.592.592 0 0 0-.65-.52l-9.9 1.15a.6.6 0 0 0-.52.65c.03.3.29.52.58.52h.07Zm11.45-13.79a.59.59 0 0 0-.21-.81l-8.57-5.09a.59.59 0 1 0-.6 1.02l8.57 5.09c.09.06.2.08.3.08.2 0 .4-.1.51-.29Z"/><path fill="#555861" d="m109.86 29.53 10.33 6.14s.08.03.12.05l.23 15.55c0 .56.31 1.08.8 1.36l14.34 8.18c.24.14.52.21.79.21.29 0 .58-.08.83-.23l14.1-8.61c.48-.29.77-.82.76-1.38l-.24-16.79c0-.56-.31-1.08-.8-1.36l-13.43-7.66-.09-7.27v-1.06c.01-.88-.7-1.6-1.58-1.6-.88 0-1.59.71-1.59 1.59v1.08l.08 7.17-12.92 7.89-10.09-6a1.598 1.598 0 1 0-1.63 2.75Zm26.16-1.82 12.74 7.26.22 14.97-12.52 7.64-12.74-7.26-.22-14.97 12.52-7.64ZM69.2 98.91a1.312 1.312 0 0 1-1.19 1.89c-.49 0-.96-.27-1.19-.74l-1.53-3.15c-.32-.65-.05-1.44.61-1.76.65-.32 1.44-.05 1.76.61l1.53 3.15Zm106.69-14.74c-.44.76-1.41 1.03-2.17.6l-7.8-4.44-13.3 8.12c-.25.16-.54.23-.83.23-.27 0-.54-.07-.79-.21l-14.27-8.14-7.63 4.66a1.593 1.593 0 0 1-1.66-2.72l8.44-5.15c.5-.3 1.12-.31 1.62-.02l14.27 8.14 13.3-8.12c.5-.3 1.12-.31 1.62-.02l8.61 4.91c.76.44 1.03 1.41.6 2.17Zm-50.96 54.44 4.27-15.2c.15-.54 0-1.13-.38-1.53l-11.43-11.92c-.4-.42-1-.59-1.56-.44l-15.1 4.01-11.09-10.7 3.4-15.42 13.01-7.13 7.95 4.53c.77.44 1.74.17 2.17-.6.44-.76.17-1.74-.6-2.17l-8.72-4.97c-.48-.27-1.07-.28-1.56-.01L91.72 84.5l-13.18-8.04c-.45-.27-1.01-.26-1.44.05l-7.8 5.48c-.6.42-.74 1.24-.32 1.84.42.6 1.24.74 1.84.32l7.1-4.98 12.56 7.67-3.43 15.55-10.69 1.13c-.72.08-1.25.73-1.17 1.45.07.68.64 1.18 1.31 1.18h.14l10.66-1.13 11.18 10.79-2.84 10.12-1.2 4.27-8.69 2.57a1.6 1.6 0 0 0-1.08 1.98c.21.69.84 1.14 1.53 1.14.15 0 .3-.02.45-.07l8.61-2.55 10.76 11.22c.3.32.72.49 1.15.49.14 0 .27-.02.41-.05l15.15-4.03 7.21 6.32c.3.26.68.4 1.05.4.44 0 .88-.18 1.2-.54.58-.66.51-1.67-.15-2.25l-7.1-6.22Zm-27.42-7.58.34-1.21 3.71-13.2 14.18-3.77 10.15 10.58-4.05 14.41-14.18 3.77-10.15-10.58Z"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> DCAF1, SPR K<sub>D</sub> = 38 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=22458#track-records" class="trecord trecord-link type-kinases"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Kinases</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>cMet mutant, IC50 = 90 nM</title><path fill="#be1f83" d="m135.24 21.19.23 10.73c0 .28-.21.5-.49.51h-.01c-.27 0-.49-.22-.5-.49l-.23-10.73c0-.28.21-.5.49-.51h.01c.27 0 .49.22.5.49Zm-3.09 11.52c.28 0 .49-.23.49-.51l-.23-11.26c0-.27-.22-.48-.51-.49-.28 0-.49.23-.49.51l.23 11.26c0 .27.23.49.5.49Zm-26 38.82a.484.484 0 0 0-.68-.17l-8.79 5.2c-.24.14-.32.45-.17.68.09.16.26.24.43.24.09 0 .17-.02.25-.07l8.79-5.2c.24-.14.32-.45.17-.68Zm0-9.84-9.4-5.36a.497.497 0 0 0-.68.19c-.14.24-.05.54.19.68l9.4 5.36c.08.04.16.07.25.07a.495.495 0 0 0 .24-.93Zm-17.6 11.47c.28 0 .49-.23.49-.51l-.15-10.54c0-.28-.23-.49-.51-.49s-.49.23-.49.51l.15 10.54c0 .27.23.49.5.49Zm77.7-22.9-8.74 5.28c-.24.14-.31.45-.17.68.09.16.26.24.43.24.09 0 .18-.02.26-.07l8.74-5.28c.24-.14.31-.45.17-.68a.493.493 0 0 0-.68-.17Zm.26-8.43c.17 0 .33-.09.43-.24a.49.49 0 0 0-.17-.68l-9.24-5.63a.493.493 0 0 0-.68.17.49.49 0 0 0 .17.68l9.24 5.63c.08.05.17.07.26.07Zm-17.3-1.8h-.01c-.27 0-.49.24-.49.51l.15 5.88c0 .27.23.49.5.49h.01c.27 0 .49-.24.49-.51l-.15-5.88a.5.5 0 0 0-.5-.49Zm-51.74 82.82-8.85-5.09a.502.502 0 0 0-.68.18c-.14.24-.05.54.18.68l8.85 5.09c.08.04.16.07.25.07.17 0 .34-.09.43-.25.14-.24.05-.54-.18-.68Zm13.77 16.45-8.38-.97a.495.495 0 0 0-.55.44c-.03.27.16.52.44.55l8.38.97h.06a.497.497 0 0 0 .05-.99Zm-5.7-32.09c-.28 0-.5.22-.5.5v10.82c0 .28.23.5.5.5s.5-.22.5-.5v-10.82c0-.28-.23-.5-.5-.5Zm-8.45-4.62-9.08 5.35c-.24.14-.32.44-.18.68a.495.495 0 0 0 .68.18l9.08-5.35c.24-.14.32-.44.18-.68a.493.493 0 0 0-.68-.18ZM144.03 6.4v-.75c0-.16-.09-.26-.25-.26h-2.7V3.81h4.19c.16 0 .25-.09.25-.26V2.7c0-.16-.09-.26-.25-.26h-5.32c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26h.88c.16 0 .25-.09.25-.26V6.64h2.7c.16 0 .25-.09.25-.26Zm34.51-3.94h-5.32c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26h.88c.16 0 .25-.09.25-.26V6.66h2.7c.16 0 .25-.09.25-.26v-.75c0-.16-.09-.26-.25-.26h-2.7V3.81h4.19c.16 0 .25-.09.25-.26V2.7c0-.16-.09-.26-.25-.26Zm-54.02 123.7h-.89c-.16 0-.25.09-.25.26v4.83l-3.89-4.94a.375.375 0 0 0-.31-.15h-.9c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26h.89c.16 0 .25-.09.25-.26v-4.8l3.89 4.91c.08.1.18.15.31.15h.9c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26Zm8.05 0h-.9c-.16 0-.25.09-.25.26v2.71h-3.8v-2.71c0-.16-.09-.26-.25-.26h-.89c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26h.89c.16 0 .25-.09.25-.26v-2.75h3.8v2.75c0 .16.09.26.25.26h.9c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26Zm-41.3-84.77h.88c.16 0 .25-.09.25-.26v-4.68L94.57 40c.07.11.17.17.3.17h.56c.13 0 .23-.06.3-.17l2.17-3.56v4.69c0 .16.09.26.25.26h.88c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26h-1.07a.34.34 0 0 0-.3.17l-2.51 4.19-2.52-4.19a.34.34 0 0 0-.3-.17h-1.08c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26Zm11.4-5.76h1.41c1.61 0 2.07.82 2.07 2.24v.92c0 .16-.09.26-.25.26h-3.99v.2c0 .71.18.87.78.87h2.76c.16 0 .25.09.25.26v.75c0 .16-.09.26-.25.26h-2.79c-1.61 0-2.07-.81-2.07-2.27v-1.24c0-1.42.46-2.24 2.07-2.24Zm.03 1.26c-.61 0-.78.16-.78.86v.27h2.92v-.27c0-.7-.17-.86-.78-.86h-1.35ZM85.39 149.92h-1.07a.34.34 0 0 0-.3.17l-2.51 4.19-2.52-4.19a.34.34 0 0 0-.3-.17h-1.08c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26h.88c.16 0 .25-.09.25-.26v-4.68l2.17 3.55c.07.11.17.17.3.17h.56c.13 0 .23-.06.3-.17l2.17-3.56v4.69c0 .16.09.26.25.26h.88c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26Zm7.11 3.72v.92c0 .16-.09.26-.25.26h-3.99v.2c0 .71.18.87.78.87h2.76c.16 0 .25.09.25.26v.75c0 .16-.09.26-.25.26h-2.79c-1.61 0-2.07-.81-2.07-2.27v-1.24c0-1.42.46-2.24 2.07-2.24h1.41c1.61 0 2.07.82 2.07 2.24Zm-1.32-.12c0-.7-.17-.86-.78-.86h-1.35c-.61 0-.78.16-.78.86v.27h2.92v-.27Zm3.84-123.47h.88c.16 0 .25-.09.25-.26v-4.68l2.17 3.55c.07.11.17.17.3.17h.56c.13 0 .23-.06.3-.17l2.17-3.56v4.69c0 .16.09.26.25.26h.88c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26h-1.07a.34.34 0 0 0-.3.17l-2.51 4.19-2.52-4.19a.34.34 0 0 0-.3-.17H95c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26Zm9.32-2.27v-1.24c0-1.42.46-2.24 2.07-2.24h1.41c1.61 0 2.07.82 2.07 2.24v.92c0 .16-.09.26-.25.26h-3.99v.2c0 .71.18.87.78.87h2.76c.16 0 .25.09.25.26v.75c0 .16-.09.26-.25.26h-2.79c-1.61 0-2.07-.81-2.07-2.27Zm1.32-1.1h2.92v-.27c0-.7-.17-.86-.78-.86h-1.35c-.61 0-.78.16-.78.86v.27Zm31.53-12.7v2.24c0 1.53-.71 2.49-2.38 2.49h-2.58c-1.66 0-2.38-.96-2.38-2.49v-2.24c0-1.54.71-2.5 2.38-2.5h2.58c1.66 0 2.38.96 2.38 2.5Zm-1.39-.05c0-.89-.28-1.09-.98-1.09h-2.58c-.69 0-.98.19-.98 1.09v2.35c0 .88.31 1.08.98 1.08h2.58c.67 0 .98-.19.98-1.08v-2.35Zm12.66 35.34h-.89c-.16 0-.25.09-.25.26v4.83l-3.89-4.94a.375.375 0 0 0-.31-.15h-.9c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26h.89c.16 0 .25-.09.25-.26v-4.8l3.89 4.91c.08.1.18.15.31.15h.9c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26Zm-30.36-7.88h.89c.16 0 .25-.09.25-.26v-4.8l3.89 4.91c.08.1.18.15.31.15h.9c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26h-.89c-.16 0-.25.09-.25.26v4.83l-3.89-4.94a.375.375 0 0 0-.31-.15h-.9c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26Zm1.92 99.05h-.89c-.16 0-.25.09-.25.26v4.83l-3.89-4.94a.375.375 0 0 0-.31-.15h-.9c-.16 0-.25.09-.25.26v6.72c0 .16.09.26.25.26h.89c.16 0 .25-.09.25-.26v-4.8l3.89 4.91c.08.1.18.15.31.15h.9c.16 0 .25-.09.25-.26v-6.72c0-.16-.09-.26-.25-.26Z"/><path fill="#ef4379" d="m133.5 58.61-11.03-6.29c-.03-.1-.05-.2-.11-.29-.02-.03-.05-.05-.08-.08l-.06-4.38-.03-2.97c0-.74-.61-1.34-1.35-1.34h-.01c-.74 0-1.34.62-1.34 1.36l.09 7.34-10.42 6.36-10.69-6.09-.11-7.91c-.01-.74-.63-1.34-1.37-1.33-.74.01-1.34.62-1.33 1.37l.11 7.6L84.24 59c-.41.25-.65.69-.65 1.17l.21 14.2c0 .48.27.92.68 1.15l11.69 6.66v15.59l-11.93 7.28c-.41.25-.65.69-.65 1.17l.21 14.2c0 .48.27.92.68 1.15l11.89 6.78 2.95 13.37-6.22 6.9a1.118 1.118 0 0 0 .83 1.86c.31 0 .61-.12.83-.37l6.22-6.91 9.27.98h.12c.56 0 1.05-.42 1.11-1a1.12 1.12 0 0 0-.99-1.23l-9.04-.96-2.85-12.92 10.78-6.58 5.8 4.07c.19.14.42.2.64.2.35 0 .7-.17.91-.47.35-.5.23-1.2-.27-1.55l-5.9-4.14-.2-13.8c0-.48-.27-.92-.68-1.15L98.4 98.22V82.14l10.41-6.35 11.62 6.63c.21.12.44.18.67.18.24 0 .49-.07.7-.2l11.93-7.28c.41-.25.65-.69.65-1.17l-.21-14.2c0-.48-.27-.92-.68-1.15ZM86.31 60.9l10.53-6.43 10.59 6.03.19 12.88-10.34 6.31-10.77-6.14-.18-12.66Zm21.55 58.4-10.59 6.47-10.77-6.14-.18-12.66 10.59-6.47 10.77 6.14.18 12.66Zm13.22-39.6-10.52-6-.19-12.78 10.49-6.4 10.62 6.06.18 12.66-10.59 6.47Zm50.27-26.95c0 .48-.24.92-.65 1.17l-11.93 7.28c-.22.13-.46.2-.7.2-.23 0-.46-.06-.67-.18l-5.52-3.15c-.65-.37-.87-1.19-.5-1.84.37-.65 1.19-.87 1.84-.5l4.83 2.75 10.59-6.47-.18-12.66-10.77-6.14-10.94 6.68.09 5.94c.01.74-.58 1.36-1.33 1.37h-.02c-.74 0-1.34-.59-1.35-1.33l-.09-6.51-10.77-6.14-4.03 2.46c-.64.39-1.47.19-1.85-.45-.39-.64-.19-1.47.45-1.85l4.71-2.88c.42-.26.94-.26 1.37-.02l11.94 6.8 10.48-6.4s-.01-.04-.01-.06l-.2-13.57-11.33-6.46c-.65-.37-.87-1.19-.5-1.84.37-.65 1.19-.87 1.84-.5l11.44 6.52 11.25-6.87c.64-.39 1.47-.19 1.85.45.39.64.19 1.47-.45 1.85l-11.41 6.97.19 13.41v.07l11.46 6.53c.41.24.67.67.68 1.15l.21 14.2Zm-59.62-23.64c-.48-.57-.42-1.42.15-1.9s1.42-.42 1.9.15l3.41 3.99a1.347 1.347 0 0 1-1.03 2.22c-.38 0-.76-.16-1.03-.47l-3.41-3.99Zm8.12 107.29-1.29 2.66c-.19.4-.59.63-1 .63-.16 0-.33-.04-.49-.11-.55-.27-.78-.94-.51-1.49l1.29-2.66c.27-.55.94-.78 1.49-.52.55.27.78.94.51 1.49Z"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> cMet mutant, IC<sub>50</sub> = 90 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=10183#track-records" class="trecord trecord-link type-enzymes"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Enzymes</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>LpxA Inhibitor, IC50= 19 nM</title><path fill="#0868b1" d="M106.58 49a.77.77 0 0 1-.77-.76l-.12-14.4a.75.75 0 0 1 .75-.77.77.77 0 0 1 .77.76l.12 14.4a.75.75 0 0 1-.75.77Zm-4.39-.2a.77.77 0 0 0 .81-.8l-.13-14.4a.76.76 0 0 0-.76-.76.77.77 0 0 0-.76.77l.13 14.4a.76.76 0 0 0 .76.76Zm-85 26.73.35-15.87a.77.77 0 0 0-.75-.78.76.76 0 0 0-.78.75l-.31 15.84a.77.77 0 0 0 .75.78.76.76 0 0 0 .78-.75Zm11.9 9.22 14.28-7.81a.77.77 0 1 0-.74-1.34L28.4 83.38a.76.76 0 0 0 .37 1.43.77.77 0 0 0 .36-.09ZM44 61.78a.76.76 0 0 0-.25-1.05L29.9 52.05a.78.78 0 0 0-1.06.25.76.76 0 0 0 .25 1.05L43 62a.76.76 0 0 0 1-.22Zm27.65 44.68L72 90.59a.77.77 0 0 0-.75-.78.75.75 0 0 0-.78.75l-.35 15.87a.77.77 0 0 0 .75.78.76.76 0 0 0 .81-.75Zm11.9 9.22 14.27-7.81a.76.76 0 0 0 .31-1 .77.77 0 0 0-1-.3l-14.27 7.81a.77.77 0 0 0-.31 1 .78.78 0 0 0 .68.39.77.77 0 0 0 .35-.09Zm14.92-22.94a.75.75 0 0 0-.24-1L84.35 83a.76.76 0 1 0-.81 1.29L97.42 93a.86.86 0 0 0 .4.11.76.76 0 0 0 .65-.37Zm66.76-20.52a.76.76 0 0 0 .68-.84l-1.26-11.47a.76.76 0 0 0-.85-.67.75.75 0 0 0-.67.84l1.26 11.47a.76.76 0 0 0 .76.68Zm15.55 3.34a.86.86 0 0 1-.37-.1.77.77 0 0 1-.3-1l6-11a.77.77 0 0 1 1.35.73l-6 11a.77.77 0 0 1-.68.37Zm-26.59 10V75.2a.36.36 0 0 1 .39-.4H156a.55.55 0 0 1 .47.24l6 7.59V75.2a.36.36 0 0 1 .39-.4h1.37a.36.36 0 0 1 .39.4v10.33a.35.35 0 0 1-.39.39h-1.39a.57.57 0 0 1-.47-.23l-6-7.55v7.39a.35.35 0 0 1-.39.39h-1.37a.35.35 0 0 1-.42-.39ZM23 27.29v-3.45c0-2.36 1.1-3.84 3.66-3.84h3.43c2.56 0 3.66 1.48 3.66 3.84v.05a.35.35 0 0 1-.39.39H32c-.25 0-.39-.11-.39-.27v-.25c0-1.37-.44-1.67-1.51-1.67h-3.44c-1.07 0-1.51.3-1.51 1.67v3.61c0 1.35.48 1.65 1.51 1.65h3.43c1 0 1.51-.3 1.51-1.65v-.3a.35.35 0 0 1 .39-.39h1.37c.25 0 .39.11.39.3v.31c0 2.35-1.1 3.83-3.66 3.83h-3.43c-2.56 0-3.66-1.48-3.66-3.83Zm12.56 3.43V19.56a.36.36 0 0 1 .39-.4h1.26a.35.35 0 0 1 .38.4v11.16a.35.35 0 0 1-.38.4H36a.36.36 0 0 1-.43-.4Zm141.83 59.61V80a.35.35 0 0 1 .38-.39h1.39a.6.6 0 0 1 .48.23l6 7.59V80a.35.35 0 0 1 .38-.39h1.37a.35.35 0 0 1 .39.39v10.33a.36.36 0 0 1-.39.4H186a.57.57 0 0 1-.48-.24l-6-7.54v7.38a.36.36 0 0 1-.39.4h-1.37a.35.35 0 0 1-.37-.4ZM117.6 63.05V52.72a.36.36 0 0 1 .39-.4h1.38a.57.57 0 0 1 .48.24l6 7.59v-7.43a.36.36 0 0 1 .39-.4h1.37a.35.35 0 0 1 .38.4v10.33a.35.35 0 0 1-.38.39h-1.41a.6.6 0 0 1-.48-.23l-6-7.55v7.39a.35.35 0 0 1-.38.39H118a.35.35 0 0 1-.4-.39Zm91.55 6.88V59.6a.35.35 0 0 1 .38-.4h1.39a.57.57 0 0 1 .48.24l6 7.59V59.6a.35.35 0 0 1 .38-.4h1.37a.36.36 0 0 1 .39.4v10.33a.35.35 0 0 1-.39.39h-1.38a.59.59 0 0 1-.48-.23l-6-7.55v7.39a.35.35 0 0 1-.38.39h-1.38a.35.35 0 0 1-.38-.39Zm12.58 0V59.6a.35.35 0 0 1 .38-.4h1.37a.36.36 0 0 1 .39.4v4.17h5.84V59.6a.36.36 0 0 1 .39-.4h1.38a.36.36 0 0 1 .39.4v10.33a.35.35 0 0 1-.39.39h-1.38a.35.35 0 0 1-.39-.39v-4.22h-5.84v4.22a.35.35 0 0 1-.39.39h-1.37a.35.35 0 0 1-.38-.39Zm12 5.41v-.82a.35.35 0 0 1 .15-.28l3.6-2.21c.68-.41.84-.55.84-1 0-.6-.22-.75-.92-.75h-1.54c-.65 0-.88.16-.88 1v.07a.21.21 0 0 1-.23.23h-.79c-.15 0-.23 0-.23-.13v-.13c0-1.37.46-2.24 2.13-2.24h1.57c1.56 0 2.13.69 2.13 1.88s-.45 1.4-1.7 2.15l-2 1.24h3.49a.2.2 0 0 1 .22.23v.76a.21.21 0 0 1-.22.23h-5.36a.21.21 0 0 1-.3-.23ZM20.57 137.78v-10.33a.35.35 0 0 1 .38-.39h1.39a.6.6 0 0 1 .48.23l6 7.6v-7.44a.35.35 0 0 1 .39-.39h1.37a.35.35 0 0 1 .39.39v10.33a.36.36 0 0 1-.39.4h-1.42a.55.55 0 0 1-.47-.24l-6-7.54v7.38a.36.36 0 0 1-.39.4H21a.35.35 0 0 1-.43-.4Zm150.87-87.46v-3.45c0-2.36 1.1-3.84 3.65-3.84h4c2.56 0 3.66 1.48 3.66 3.84v3.45c0 2.34-1.1 3.83-3.66 3.83h-4c-2.55 0-3.65-1.49-3.65-3.83Zm7.61 1.73c1 0 1.51-.3 1.51-1.65v-3.61c0-1.37-.43-1.67-1.51-1.67h-4c-1.06 0-1.51.3-1.51 1.67v3.61c0 1.35.48 1.65 1.51 1.65ZM62.19 49.53a.35.35 0 0 1 .37-.41h1.38a.35.35 0 0 1 .38.39c.09.92.51 1.26 1.51 1.26h3c1.17 0 1.59-.29 1.59-1.21S70 48.44 69 48.36l-3.44-.26c-2.37-.19-3.31-1-3.31-3.06s1-3.29 3.68-3.29h2.82c2.43 0 3.53 1.12 3.64 3.34a.35.35 0 0 1-.37.41h-1.38c-.25 0-.37-.14-.39-.4-.09-.91-.5-1.26-1.49-1.26H66c-1.19 0-1.6.29-1.6 1.22s.4 1.08 1.43 1.16l3.44.27c2.34.19 3.33 1 3.33 3.09s-1 3.29-3.7 3.29h-3c-2.52 0-3.6-1.12-3.71-3.34Zm35.94-22.94v-3.45c0-2.36 1.09-3.84 3.65-3.84h4c2.56 0 3.66 1.48 3.66 3.84v3.45c0 2.35-1.1 3.83-3.66 3.83h-4c-2.56 0-3.65-1.48-3.65-3.83Zm7.61 1.74c1 0 1.51-.3 1.51-1.66v-3.61c0-1.37-.43-1.67-1.51-1.67h-4c-1.06 0-1.51.3-1.51 1.67v3.61c0 1.36.48 1.66 1.51 1.66Zm-73.42 95.46a.79.79 0 0 1-.68-.4.77.77 0 0 1 .31-1l12.65-6.88a.77.77 0 0 1 .74 1.35l-12.66 6.87a.68.68 0 0 1-.36.06Zm4.73 8.21a.77.77 0 0 1-.67-.4.76.76 0 0 1 .3-1l12.66-6.88a.77.77 0 1 1 .73 1.35l-12.66 6.87a.68.68 0 0 1-.36.06Z"/><path fill="#2aa1db" d="M29.7 91.67a1.68 1.68 0 0 1-.9-.26L10.33 80a1.72 1.72 0 0 1-.81-1.48l.24-21.71a1.71 1.71 0 0 1 .89-1.48L29.35 45a1.73 1.73 0 0 1 1.73 0l18.47 11.47a1.74 1.74 0 0 1 .81 1.53l-.24 21.72a1.73 1.73 0 0 1-.89 1.48L30.52 91.45a1.6 1.6 0 0 1-.82.22ZM13 77.59 29.75 88l17-9.34.22-19.75L30.13 48.5l-16.95 9.34Zm35.4 2.06Zm56.32 11.17 18.71-10.31a1.74 1.74 0 0 0 .89-1.52l-.14-11.77a1.72 1.72 0 0 0-3.43 0l.13 10.78-17.81 9.81a1.72 1.72 0 0 0 1.65 3ZM50.2 58.33l8.68-4.79a1.71 1.71 0 1 0-1.65-3l-8.68 4.79a1.71 1.71 0 0 0 1.65 3Zm34 64.3a1.68 1.68 0 0 1-.9-.26L64.78 111a1.71 1.71 0 0 1-.81-1.48l.24-21.71a1.71 1.71 0 0 1 .89-1.48L83.8 76a1.73 1.73 0 0 1 1.73 0L104 87.43a1.75 1.75 0 0 1 .82 1.48l-.24 21.72a1.73 1.73 0 0 1-.89 1.48L85 122.41a1.6 1.6 0 0 1-.85.22Zm-16.79-14.08 16.79 10.38 17-9.34.22-19.75-16.84-10.38-17 9.35Zm35.44 2.06Zm85.51-34.16 6.16-11.66a1.73 1.73 0 0 0-.26-2l-6.7-7.18a1.71 1.71 0 0 0-2.51 2.39l5.87 6.29-5.59 10.59a1.71 1.71 0 0 0 .71 2.31 1.66 1.66 0 0 0 .8.2 1.72 1.72 0 0 0 1.52-.94Zm-13.84 5.67a1.72 1.72 0 0 0-1.37-2l-3.89-.73a1.71 1.71 0 0 0-.63 3.37l3.89.73a1.72 1.72 0 0 0 .32 0 1.7 1.7 0 0 0 1.68-1.37Zm-14.69-10.35a1.71 1.71 0 0 0 1.47-1.93l-1.57-11.65 7.65-3.69a1.72 1.72 0 1 0-1.49-3.09l-8.76 4.23a1.73 1.73 0 0 0-1 1.78l1.74 12.88a1.7 1.7 0 0 0 1.69 1.48Zm45-5.58h-11.4a1.72 1.72 0 0 1 0-3.43h11.36a1.72 1.72 0 1 1 0 3.43ZM31.9 46.43V35.07a1.71 1.71 0 1 0-3.42 0v11.36a1.71 1.71 0 0 0 3.42 0Zm4.1 82.06 30.42-17.05a1.71 1.71 0 0 0-1.68-3l-30.41 17a1.71 1.71 0 0 0 .84 3.21 1.66 1.66 0 0 0 .83-.16ZM159.51 58a1.71 1.71 0 0 0-.55-2.36l-16.84-10.57a1.7 1.7 0 0 0-1.73 0l-10.17 5.6a1.71 1.71 0 1 0 1.65 3l9.29-5.11 16 10a1.65 1.65 0 0 0 .9.26 1.72 1.72 0 0 0 1.45-.82Zm-72 1.42 17-10.85 9.16 5.21a1.71 1.71 0 0 0 1.69-3l-10-5.72a1.71 1.71 0 0 0-1.77 0L86.53 55.91 78 50.65a1.71 1.71 0 1 0-1.8 2.91l9.42 5.83a1.73 1.73 0 0 0 .91.25 1.7 1.7 0 0 0 .94-.27Z"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> LpxA Inhibitor, IC<sub>50</sub>= 19 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Infectious Disease </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5589#track-records" class="trecord trecord-link type-enzymes"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Enzymes</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>HAO1 Inhibitor, IC50= 25 nM</title><path d="M210.44 56.54a.68.68 0 01-.5-.22l-8.25-9.44a.66.66 0 011-.85l8.26 9.44a.66.66 0 01-.07.93.69.69 0 01-.43.16zm-2.2 2.51a.64.64 0 00.07-.92l-8.24-9.43a.66.66 0 00-1 .87l8.25 9.43a.66.66 0 00.93.06zM40 99a.66.66 0 00.21-.92L33 86.14a.66.66 0 00-.85-.37.65.65 0 00-.37.85.57.57 0 00.13.21l7.24 12a.62.62 0 00.55.32.67.67 0 00.3-.15zm49.22-24a.62.62 0 01-.32-.09l-11.74-6.64a.66.66 0 11.65-1.14l11.74 6.66a.66.66 0 01.25.9.7.7 0 01-.57.33zm11.14-6.17a.65.65 0 01-.65-.64l-.35-14.29a.66.66 0 111.31 0l.33 14.28a.66.66 0 01-.64.67zM77.2 55.67a.66.66 0 01-.35-1.22l11.83-7.32a.66.66 0 11.87 1 .42.42 0 01-.18.11l-11.82 7.33a.64.64 0 01-.35.1zm80.29 41.89a.64.64 0 01-.66-.64l-.15-14.15a.66.66 0 01.66-.66.65.65 0 01.65.65l.15 14.19a.65.65 0 01-.65.66zm11.27 6.68a.65.65 0 01-.66-.66.68.68 0 01.31-.56l12.06-7.36a.66.66 0 01.91.22.67.67 0 01-.22.91l-12.06 7.36a.6.6 0 01-.34.11zm11.85-20.38a.63.63 0 01-.33-.09l-12-7a.65.65 0 01-.24-.89.66.66 0 01.9-.25l12 7a.65.65 0 01-.33 1.22zm25.76 3.22a.65.65 0 01-.54-.28l-5.66-7.8a.67.67 0 111.1-.76l5.65 7.84a.65.65 0 01-.15.91.67.67 0 01-.38.13zm-155.1 5.47a.65.65 0 01-.6-.7l.55-9.52a.66.66 0 01.69-.62.65.65 0 01.62.7L52 91.93a.66.66 0 01-.73.62zM34.82 74.82a.3.3 0 01.24-.35.22.22 0 01.08 0h1.18c.22 0 .32.12.34.34.07.78.43 1.09 1.3 1.09h2.59c1 0 1.36-.25 1.36-1s-.34-1-1.22-1l-3-.23c-2-.16-2.85-.84-2.85-2.63s.86-2.83 3.17-2.83h2.42c2.1 0 3 1 3.13 2.87a.3.3 0 01-.23.35.14.14 0 01-.09 0h-1.15c-.21 0-.31-.12-.33-.34-.08-.78-.43-1.09-1.28-1.09h-2.4c-1 0-1.38.24-1.38 1s.35.93 1.23 1l3 .23c2 .16 2.86.88 2.86 2.66s-.86 2.83-3.18 2.83H38c-2.13 0-3-1-3.13-2.87zm49.39 26.83v-3c0-2 1-3.29 3.15-3.29h3.4c2.19 0 3.14 1.27 3.14 3.29v3c0 2-.94 3.29-3.14 3.29h-3.4c-2.19 0-3.14-1.25-3.14-3.27zm6.55 1.48c.89 0 1.3-.25 1.3-1.42v-3.1c0-1.18-.37-1.44-1.3-1.44h-3.4c-.91 0-1.3.26-1.3 1.44v3.1c0 1.17.41 1.42 1.3 1.42zm4.89 1.47v-8.88a.3.3 0 01.26-.34h1.25a.29.29 0 01.33.27.08.08 0 010 .07v3.58h5v-3.58a.3.3 0 01.26-.34H104a.3.3 0 01.33.27v8.95a.32.32 0 01-.26.34h-1.27a.32.32 0 01-.33-.27V101h-5v3.63a.31.31 0 01-.26.34H96a.31.31 0 01-.33-.28.13.13 0 010-.06zm36.46-40v-8.87a.29.29 0 01.26-.33h1.24a.32.32 0 01.34.28v3.65h5v-3.6a.29.29 0 01.26-.33h1.26a.3.3 0 01.33.27.08.08 0 010 .07v8.89a.29.29 0 01-.26.33h-1.24a.31.31 0 01-.33-.27V61h-5v3.63a.31.31 0 01-.27.34h-1.24a.3.3 0 01-.34-.26.11.11 0 01-.01-.09zM131.9 76v-8.9a.3.3 0 01.27-.33h1.24a.47.47 0 01.41.2L139 73.5v-6.4a.29.29 0 01.26-.33h1.25a.31.31 0 01.33.27V76a.31.31 0 01-.27.34h-1.26a.51.51 0 01-.41-.2l-5.14-6.49V76a.3.3 0 01-.26.34h-1.25a.3.3 0 01-.32-.29zm67 34.49v-8.89a.3.3 0 01.27-.33h1.26a.48.48 0 01.41.2L206 108v-6.39a.3.3 0 01.26-.33h1.25a.3.3 0 01.33.26v9a.3.3 0 01-.27.34h-1.27a.49.49 0 01-.42-.2l-5.12-6.48v6.35a.29.29 0 01-.26.34h-1.24a.3.3 0 01-.34-.27zm.2 11.38V113a.3.3 0 01.27-.34h1.24a.29.29 0 01.33.27v3.66h5V113a.31.31 0 01.27-.34h1.26a.3.3 0 01.33.28v9a.3.3 0 01-.26.33h-1.28a.3.3 0 01-.34-.26v-3.7h-5v3.63a.3.3 0 01-.27.33h-1.24a.29.29 0 01-.31-.29zm-8.84-77.78v-3c0-2 .94-3.29 3.14-3.29h3.41c2.19 0 3.14 1.27 3.14 3.29v3c0 2-.94 3.29-3.14 3.29h-3.41c-2.15-.01-3.09-1.28-3.09-3.3zm6.55 1.49c.89 0 1.3-.26 1.3-1.42V41c0-1.18-.38-1.43-1.3-1.43h-3.41c-.91 0-1.3.25-1.3 1.43v3.11c0 1.16.41 1.42 1.3 1.42zm13.57 48.6v-8.89a.3.3 0 01.27-.34H212a.48.48 0 01.41.2l5.14 6.53v-6.39a.3.3 0 01.28-.33H219a.32.32 0 01.33.27v9a.3.3 0 01-.26.33h-1.25a.51.51 0 01-.41-.21l-5.15-6.48v6.35a.29.29 0 01-.25.33h-1.26a.32.32 0 01-.34-.28v-.07zm13.34-40.28V51c0-2 .94-3.29 3.14-3.29h3.41c2.19 0 3.14 1.27 3.14 3.29v3c0 2-.95 3.29-3.14 3.29h-3.41c-2.2-.1-3.14-1.39-3.14-3.39zm6.55 1.49c.88 0 1.3-.25 1.3-1.42v-3.1c0-1.18-.38-1.43-1.3-1.43h-3.41c-.91 0-1.3.25-1.3 1.43V54c0 1.17.41 1.42 1.3 1.42zm4.88 1.46V48a.3.3 0 01.27-.34h1.24a.3.3 0 01.33.27.08.08 0 010 .07v3.59h5V48a.32.32 0 01.28-.34h1.25a.3.3 0 01.33.28.06.06 0 010 .06v8.88a.3.3 0 01-.27.34h-1.25a.3.3 0 01-.34-.27v-3.7h-5v3.63a.3.3 0 01-.26.34.16.16 0 01-.07 0h-1.17a.3.3 0 01-.34-.27v-.07zM49.94 104v-8.93a.32.32 0 01.28-.34h1.25a.51.51 0 01.41.2l5.12 6.53v-6.39a.31.31 0 01.27-.34h1.24a.3.3 0 01.33.28.06.06 0 010 .06V104a.29.29 0 01-.26.33h-1.24a.47.47 0 01-.41-.2l-5.14-6.53v6.4a.3.3 0 01-.27.33h-1.24a.3.3 0 01-.34-.26z" fill="#0868b1"/><path d="M47.21 100.66a1.48 1.48 0 01-1.06 1.8l-7.94 2L31.08 121a1.48 1.48 0 01-1.35.89 1.52 1.52 0 01-.59-.12 1.48 1.48 0 01-.77-1.94l7.13-16.5-9.31-15.09-18.64-1.68A1.48 1.48 0 016.13 85a1.46 1.46 0 011.52-1.42h.16l18.61 1.69 5-6.14a1.48 1.48 0 112.38 1.75l-.1.12-4.83 6 9 14.58 7.6-2a1.49 1.49 0 011.74 1.08zm82.62-25.57a1.46 1.46 0 01-.58 2l-7.87 4.3a1.49 1.49 0 01-1.49 0l-14.61-9.19-14.57 8.92v10.77a1.48 1.48 0 01-2.95 0V81.12l-14.93-8.51-14.62 7.53-.72 10.68A1.47 1.47 0 0156 92.19h-.1a1.47 1.47 0 01-1.38-1.54l.69-10.45-7.6-3.12a1.48 1.48 0 011.1-2.75l8 3.27L71.38 70l-.26-18a1.77 1.77 0 01.88-1.52l15.75-9.62a1.78 1.78 0 011.81 0l16 9.14a1.79 1.79 0 01.89 1.54l.27 18.17 14 8.7 7.13-3.91a1.47 1.47 0 011.98.59zM103.2 69.3l-.2-16.73-14.3-8.12L74.72 53 75 69.73l14.25 8.11zm116.71-13.76l-10.26 2.24-5.39 16.45 5.74 7.55a1.48 1.48 0 01-2.35 1.78l-5.56-7.34-15.5 4.78.24 16.8 8.51 2.78a1.47 1.47 0 01-.46 2.87 1.41 1.41 0 01-.45-.07l-8.77-2.87-15.41 9.41a1.79 1.79 0 01-.93.26 1.81 1.81 0 01-.88-.23l-16-9.15a1.77 1.77 0 01-.9-1.52l-.27-18.13-7.95-4.68a1.47 1.47 0 011.5-2.53l7.87 4.65 15.15-9.24a1.73 1.73 0 011.81 0l15.73 9 16.11-4.93 5.66-17.31a1.48 1.48 0 011.1-1l11.09-2.42a1.47 1.47 0 11.77 2.84h-.15zm-36.66 42.21L183 81l-14.25-8.1-14 8.57.25 16.73 14.26 8.12zm26.28-2.36a1.48 1.48 0 00-2 .55l-.6 1.06a1.47 1.47 0 00.55 2 1.42 1.42 0 00.73.19 1.44 1.44 0 001.28-.75l.59-1a1.48 1.48 0 00-.55-2z" fill="#2aa1db"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> HAO1 Inhibitor, IC<sub>50</sub>= 25 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Rare Disease </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5622#track-records" class="trecord trecord-link type-receptors"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Receptors</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>ERa Binder, IC50= 50 nM</title><path d="M80.44 72.7a.7.7 0 01-.71-.7l-.06-14.86a.71.71 0 01.69-.73.71.71 0 01.72.71L81.14 72a.71.71 0 01-.72.71zm12 7.4l13-7.9a.72.72 0 00.18-1 .71.71 0 00-.91-.24l-13.06 7.92a.71.71 0 00.52 1.33.79.79 0 00.23-.14zM105.66 58a.72.72 0 00-.27-1l-13.07-7.5a.71.71 0 00-.71 1.24l13.07 7.54a.74.74 0 001-.26zm-13.85 54.75H95c2.38 0 3.4-1.38 3.4-3.56v-.28c0-.17-.13-.28-.36-.28h-1.27a.33.33 0 00-.35.31.06.06 0 000 .06v.28c0 1.27-.45 1.55-1.41 1.55h-3.2c-1 0-1.41-.28-1.41-1.55v-3.36c0-1.28.41-1.55 1.41-1.55H95c1 0 1.41.27 1.41 1.55v.24c0 .15.13.25.35.25h1.28a.34.34 0 00.36-.3.08.08 0 000-.07c0-2.21-1-3.57-3.4-3.57h-3.2c-2.38 0-3.41 1.38-3.41 3.57v3.21c.01 2.12 1.03 3.5 3.42 3.5zm8.66 0h1.19a.33.33 0 00.36-.3V102a.34.34 0 00-.29-.37h-1.26a.33.33 0 00-.36.29v10.48a.33.33 0 00.28.37zm62.46 0h3.21c2.37 0 3.4-1.38 3.4-3.56v-.28c0-.17-.13-.28-.36-.28h-1.28a.34.34 0 00-.36.3v.35c0 1.27-.44 1.55-1.4 1.55H163c-1 0-1.41-.28-1.41-1.55v-3.36c0-1.28.41-1.55 1.41-1.55h3.2c1 0 1.41.27 1.41 1.55v.24c0 .15.12.25.35.25h1.28a.34.34 0 00.36-.3.16.16 0 000-.07c0-2.21-1-3.57-3.4-3.57H163c-2.38 0-3.41 1.38-3.41 3.57v3.21c0 2.16 1 3.54 3.41 3.54zm8.72 0h1.27a.32.32 0 00.35-.29.22.22 0 000-.08v-4h3.86a.34.34 0 00.37-.3V107a.34.34 0 00-.3-.37h-3.93v-2.26h6a.33.33 0 00.36-.3.13.13 0 000-.06v-1.19a.32.32 0 00-.28-.37h-7.7a.33.33 0 00-.36.29v9.7a.33.33 0 00.32.34zm10.19 4.89h1.73c1.36 0 2-.54 2-1.64v-.08a1.39 1.39 0 00-.65-1.31 1.35 1.35 0 00.6-1.26v-.09c0-1.1-.64-1.66-2-1.66h-1.67c-1.31 0-1.92.59-2 1.78a.21.21 0 00.16.22h.79a.2.2 0 00.22-.19c0-.6.28-.69.81-.69h1.63c.59 0 .87.14.87.66v.13c0 .5-.26.6-.76.6h-1.49a.19.19 0 00-.21.17v.58a.19.19 0 00.16.22h1.6c.51 0 .76.13.76.64v.13c0 .52-.27.63-.86.63h-1.69c-.53 0-.77-.12-.81-.68a.2.2 0 00-.19-.22h-.77a.19.19 0 00-.21.18 1.71 1.71 0 002 1.86zM33.19 92h1.29a.32.32 0 00.35-.29.11.11 0 000-.08v-3.98h5.44v3.93a.34.34 0 00.28.37h1.38a.32.32 0 00.35-.29.11.11 0 000-.08V82a.33.33 0 00-.29-.36h-1.36a.33.33 0 00-.36.29v4h-5.44V82a.33.33 0 00-.29-.36h-1.35a.33.33 0 00-.36.29.15.15 0 000 .07v9.63a.32.32 0 00.28.37zm14.39 0h3.67c2.38 0 3.41-1.38 3.41-3.56v-3.29c0-2.21-1-3.57-3.41-3.57h-3.67c-2.38 0-3.4 1.38-3.4 3.57v3.21c0 2.21 1.02 3.64 3.4 3.64zm0-2c-1 0-1.41-.28-1.41-1.54V85.1c0-1.28.42-1.56 1.41-1.56h3.67c1 0 1.41.28 1.41 1.56v3.36c0 1.26-.44 1.54-1.41 1.54zm92.09-10.42H141a.31.31 0 00.35-.29.11.11 0 000-.08v-6.88l5.58 7a.54.54 0 00.44.22h1.3a.32.32 0 00.35-.3v-9.7a.33.33 0 00-.29-.36h-1.36a.33.33 0 00-.36.29v7l-5.57-7.07a.54.54 0 00-.45-.22h-1.29a.33.33 0 00-.36.29v9.7a.32.32 0 00.29.37h.09zm1.07-22.11H142a.33.33 0 00.36-.29v-6.79l3.11 5.09a.48.48 0 00.43.25h.81a.47.47 0 00.43-.25l3.11-5.1v6.72a.34.34 0 00.3.37h1.33a.33.33 0 00.36-.29v-9.71a.33.33 0 00-.29-.36h-1.61a.46.46 0 00-.43.25l-3.57 6-3.6-6a.46.46 0 00-.43-.25h-1.59a.33.33 0 00-.36.29v9.7a.33.33 0 00.28.37h.09zm16.31 0h4a.33.33 0 00.36-.29V56a.32.32 0 00-.28-.37h-4c-.86 0-1.11-.24-1.11-1.25v-.29h5.71a.33.33 0 00.36-.31v-1.35c0-2-.66-3.21-3-3.21h-2c-2.31 0-3 1.19-3 3.21v1.78c0 2.1.64 3.26 2.95 3.26zM156 52.64v-.38c0-1 .24-1.24 1.11-1.24H159c.88 0 1.12.24 1.12 1.24v.38z" fill="#30a74d"/><path d="M217 68l-10.05-18.3a1.59 1.59 0 00-1.72-.8L185.08 53a1.58 1.58 0 00-1.26 1.38l-2.33 20-17.36 10.43-10.87-6.53a1.6 1.6 0 00-1.65 2.72l11.25 6.77v9.72a1.6 1.6 0 103.19 0V87.38l17-10.22L201 85.58a1.57 1.57 0 00.68.15 1.6 1.6 0 001.18-.52l13.91-15.41A1.59 1.59 0 00217 68zm-15.76 14.18L184.7 74.4l2.15-18.55 17.83-3.63 8.91 16.28zm-66-3.46l-8.15 4.6L112 73.86l-.29-19.68a1.9 1.9 0 00-1-1.65l-17.36-9.9a1.91 1.91 0 00-2 0L74.36 53.07a1.92 1.92 0 00-.92 1.67l.28 19.52-16.56 8.54a1.6 1.6 0 00.73 3 1.58 1.58 0 00.73-.18l16.64-8.57 16.19 9.22V98a1.6 1.6 0 003.19 0V86.27l15.8-9.65 15.83 9.91a1.58 1.58 0 00.84.25 1.5 1.5 0 00.78-.21l9-5.06a1.6 1.6 0 00-1.57-2.78zM93 82.73l-15.45-8.8-.26-18.13 15.2-9.27 15.45 8.79.26 18.14zm52.54-21.12v4.59a1.6 1.6 0 11-3.19.19.61.61 0 010-.19v-4.59a1.6 1.6 0 113.19-.19z" fill="#9aca3c"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> ERa Binder, IC<sub>50</sub>= 50 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5626#track-records" class="trecord trecord-link type-receptors"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Receptors</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>PAR2 Antagonist, IC50= 23 nM</title><path d="M98.91 80.55a.68.68 0 01-.56-.3l-6.52-10.56a.65.65 0 011.11-.69l6.52 10.55a.66.66 0 01-.21.9.72.72 0 01-.34.1zm-2.64 2.07a.64.64 0 00.21-.89L90 71.17a.65.65 0 10-1.1.69l6.52 10.55a.65.65 0 00.55.31.59.59 0 00.3-.1zM7.73 99.19H8.9a.3.3 0 00.32-.34v-6.26L14.3 99a.48.48 0 00.4.2h1.18a.3.3 0 00.32-.34v-8.77a.3.3 0 00-.32-.34h-1.17a.3.3 0 00-.32.34v6.3L9.32 90a.51.51 0 00-.41-.2H7.73a.3.3 0 00-.32.34v8.76a.3.3 0 00.32.29zm13.3 0h2.91c2.17 0 3.1-1.26 3.1-3.25v-.27c0-.16-.12-.25-.33-.25h-1.16a.3.3 0 00-.33.33V96c0 1.15-.4 1.4-1.28 1.4H21c-.88 0-1.28-.25-1.28-1.4v-3c0-1.16.37-1.42 1.28-1.42h2.91c.9 0 1.28.26 1.28 1.42v.21c0 .13.12.23.33.23h1.16a.3.3 0 00.33-.34c0-2-.93-3.26-3.1-3.26H21c-2.17 0-3.1 1.26-3.1 3.26v2.93c.03 1.9.96 3.16 3.1 3.16zm165.11-9.79h1.15a.3.3 0 00.33-.34V83l2.84 4.63a.43.43 0 00.39.23h.73a.43.43 0 00.39-.23l2.84-4.65v6.12a.3.3 0 00.33.34h1.15a.3.3 0 00.32-.34v-8.8a.3.3 0 00-.32-.33h-1.4a.47.47 0 00-.4.22l-3.26 5.47-3.23-5.47a.47.47 0 00-.4-.22h-1.41a.29.29 0 00-.32.33v8.76a.3.3 0 00.27.34zm14.85 0h3.63a.3.3 0 00.33-.34v-1a.3.3 0 00-.33-.34H201c-.79 0-1-.21-1-1.13v-.27h5.2a.3.3 0 00.33-.33v-1.18c0-1.85-.61-2.92-2.71-2.92H201c-2.11 0-2.71 1.07-2.71 2.92v1.62c-.01 1.91.59 2.97 2.71 2.97zM200 85v-.35c0-.9.22-1.12 1-1.12h1.76c.8 0 1 .22 1 1.12V85zM87.73 102.77h1.17a.3.3 0 00.32-.34v-6.26l5.08 6.39a.46.46 0 00.4.21h1.18a.3.3 0 00.32-.34v-8.76a.3.3 0 00-.32-.34h-1.17a.3.3 0 00-.32.34V100l-5.07-6.44a.51.51 0 00-.41-.2h-1.18a.3.3 0 00-.32.34v8.76a.3.3 0 00.32.31zm10.67 0h1.17a.3.3 0 00.32-.34v-3.58h5v3.58a.31.31 0 00.33.34h1.17a.31.31 0 00.33-.34v-8.76a.3.3 0 00-.33-.34h-1.17a.3.3 0 00-.33.34v3.54h-5v-3.54a.3.3 0 00-.32-.34H98.4a.3.3 0 00-.32.34v8.76a.3.3 0 00.32.34zM84.5 69.68h3.36c2.17 0 3.1-1.25 3.1-3.24v-2.93c0-2-.93-3.26-3.1-3.26H84.5c-2.17 0-3.1 1.26-3.1 3.26v2.93c0 1.99.93 3.24 3.1 3.24zm0-1.78c-.88 0-1.28-.25-1.28-1.4v-3.06c0-1.16.38-1.41 1.28-1.41h3.36c.91 0 1.28.25 1.28 1.41v3.06c0 1.15-.41 1.4-1.28 1.4zm143.1-39.09h3.4c2.17 0 3.1-1.25 3.1-3.25v-2.92c0-2-.93-3.26-3.1-3.26h-3.4c-2.17 0-3.1 1.25-3.1 3.26v2.92c0 2 .93 3.25 3.1 3.25zm0-1.78c-.88 0-1.29-.25-1.29-1.4v-3.06c0-1.16.38-1.41 1.29-1.41h3.4c.92 0 1.29.25 1.29 1.41v3.06c0 1.15-.41 1.4-1.29 1.4zm1 32.2h3.36c2.17 0 3.1-1.26 3.1-3.25v-2.92c0-2-.93-3.26-3.1-3.26h-3.36c-2.17 0-3.1 1.25-3.1 3.26V56c-.03 2 .9 3.23 3.07 3.23zm0-1.78c-.88 0-1.28-.25-1.28-1.4V53c0-1.16.38-1.42 1.28-1.42h3.36c.91 0 1.28.26 1.28 1.42v3.06c0 1.15-.41 1.4-1.28 1.4zm-67 23h1.17a.3.3 0 00.32-.33v-6.23l5.07 6.39a.48.48 0 00.41.2h1.18a.3.3 0 00.32-.33v-8.76a.3.3 0 00-.32-.34h-1.17a.3.3 0 00-.32.34v6.3l-5.08-6.44a.48.48 0 00-.4-.2h-1.18a.3.3 0 00-.32.34v8.76a.29.29 0 00.26.33zm-14.32-25.2h1.17a.29.29 0 00.32-.33v-6.27l5.08 6.4a.48.48 0 00.4.2h1.18a.29.29 0 00.32-.33v-8.77a.29.29 0 00-.32-.33h-1.17a.29.29 0 00-.32.33v6.31L148.86 46a.48.48 0 00-.4-.2h-1.18a.29.29 0 00-.32.33v8.77a.29.29 0 00.32.35zm7.82-28.92h5.15c2.21 0 3.09-.85 3.09-2.56v-.12a2.22 2.22 0 00-1-2.07 2.05 2.05 0 001-1.95v-.13c0-1.72-.9-2.61-3.11-2.61h-5.13a.3.3 0 00-.32.34V26a.3.3 0 00.32.33zm1.48-5.48v-2.18h3.47c.83 0 1.34.21 1.34 1v.21c0 .78-.51 1-1.19 1zm0 3.71v-2.21h3.69c.7 0 1.21.22 1.21 1v.21c0 .81-.53 1-1.34 1zm12-5.74a1.94 1.94 0 00-1.9.87v-.54a.3.3 0 00-.33-.33h-1.07a.29.29 0 00-.32.33V26a.3.3 0 00.32.34h1.07a.3.3 0 00.33-.34v-4.4c0-1 .31-1.14 1-1.14h1.88a.3.3 0 00.33-.33v-1a.3.3 0 00-.33-.33zM44.41 94.77L51 83a.65.65 0 00-1.14-.63l-6.59 11.77a.65.65 0 00.25.88.62.62 0 00.32.09.64.64 0 00.57-.34zm5.25 11.64l13.79-.17a.65.65 0 000-1.3l-13.8.17a.65.65 0 00-.64.66.64.64 0 00.65.64zm20.28-11.26a.64.64 0 00.23-.88l-7-12a.65.65 0 10-1.12.65l6.95 12a.66.66 0 00.56.32.68.68 0 00.38-.09zm46.82-14.69l6.57-11.75a.65.65 0 10-1.13-.64l-6.57 11.76a.64.64 0 00.25.88.6.6 0 00.31.08.65.65 0 00.57-.33zM122 92.1l13.8-.17a.65.65 0 000-1.3l-13.8.17a.65.65 0 000 1.3zm20.28-11.26a.65.65 0 00.24-.89l-6.95-12a.65.65 0 00-.89-.23.64.64 0 00-.24.88l7 12a.65.65 0 00.57.33.62.62 0 00.28-.09zM208.39 34a.65.65 0 00-.25-.88l-11.57-6.58a.64.64 0 10-.64 1.12l11.57 6.54a.61.61 0 00.32.08.63.63 0 00.57-.28zm-44.58 27.3a.65.65 0 00-.29-.87l-6.32-3.18a.66.66 0 00-.88.29.65.65 0 00.29.87l6.32 3.18a.65.65 0 00.29.07.66.66 0 00.59-.36zm21.78-13.44a.64.64 0 00.64-.66l-.33-14.1a.64.64 0 00-.65-.63.65.65 0 00-.64.66l.33 14.1a.65.65 0 00.65.63zm11.16 6.08l11.68-7.24a.65.65 0 00-.68-1.1l-11.68 7.24a.64.64 0 00-.21.89.65.65 0 00.55.31.59.59 0 00.34-.1z" fill="#2fa64d"/><path d="M171.81 106l3.32-15.86a1.49 1.49 0 000-.47l7.87-.97-1-3.88-7 4.23a1.33 1.33 0 00-.23-.3l-6.2-6.11a1.45 1.45 0 00-2 2.07l5.64 5.56-3.21 15.07-16.45 5.4a1.46 1.46 0 00-1 1.08l-3.83 18.1a1.45 1.45 0 00.44 1.36l13.42 12.44a1.47 1.47 0 001 .39 1.42 1.42 0 00.42-.11l17.25-5.66a1.46 1.46 0 001-1.08l3.82-18.1a1.44 1.44 0 00-.43-1.36zm6.76 29.92L162.93 141l-12.19-11.29 3.48-16.47 15.64-5.13 12.19 11.29zM82.48 93.21h-6.39l-9.2-15.73a1.52 1.52 0 00-1.28-.72L47.5 77a1.46 1.46 0 00-1.25.76l-8.41 15.45h-7.55a1.46 1.46 0 000 2.91h7.58l8.87 15.17A1.45 1.45 0 0048 112l18.11-.28a1.46 1.46 0 001.25-.76l8.11-14.85h7a1.46 1.46 0 000-2.91zm-17.24 15.63l-16.42.25-8.45-14.45 8-14.71 16.42-.25 8.19 14a1.42 1.42 0 00-.38 1 1.37 1.37 0 00.09.49zm91.62-28.76a1.45 1.45 0 10-.26-2.89l-8.7.78-8.08-13.81 5.5-6a1.45 1.45 0 00-2.14-2l-5.74 6.23-17.59.28a1.43 1.43 0 00-1.25.75L110.14 79H96.9a1.45 1.45 0 00-1.21.66l-5.75 8.8a1.45 1.45 0 00.43 2 1.42 1.42 0 00.79.23 1.46 1.46 0 001.22-.69l5.31-8.13h12.59L119.1 97a1.45 1.45 0 001.25.72l18.11-.28a1.46 1.46 0 001.26-.76l8.62-15.81zm-19.27 14.44l-16.41.26-8.45-14.45 8-14.71 16.41-.25 8.45 14.45zm104.58-54.75L237 47.58a1.45 1.45 0 11-2.42-1.58l4.59-7-5.25-6.89a1.45 1.45 0 112.31-1.76l5.88 7.71a1.48 1.48 0 01.06 1.71zm-20.48 10.91l-7.87-2.32-.44-16.95 8.21-3a1.46 1.46 0 10-1-2.73l-8.79 3.26-15.1-8.37a1.46 1.46 0 00-1.47 0L180 30.12l-8.36-5.6a1.45 1.45 0 10-1.64 2.41l8.46 5.67a1.53 1.53 0 00.67.23l.42 16.36-11.7 7.13-7.79-3.76a1.46 1.46 0 10-1.27 2.62l7.58 3.65-1 8.21a1.45 1.45 0 001.27 1.62h.18a1.46 1.46 0 001.44-1.27l1.06-8.55 11.77-7.18 15.18 8.42a1.47 1.47 0 00.71.18 1.43 1.43 0 00.77-.22l14.54-9.11 8.61 2.53a1.51 1.51 0 00.41.06 1.46 1.46 0 00.41-2.85zm-24.79 6.45l-14.44-8-.46-16.86 14-8.78 14.45 8 .44 16.85z" fill="#9aca3c"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> PAR2 Antagonist, IC<sub>50</sub>= 23 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Neurology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5633#track-records" class="trecord trecord-link type-receptors"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Receptors</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>PAR2 Agonist, EC50= 230 nM</title><path d="M49.91 80.93L40.4 80a1.38 1.38 0 00-1.25.55l-10.45 14a1.33 1.33 0 00-.25.57L12 93.5a1.37 1.37 0 00-1.24.55l-10.46 14a1.4 1.4 0 00-.15 1.38l7 15.74a1.41 1.41 0 001.05.83l17.42 1.72h.13a1.37 1.37 0 001.11-.55l10.45-14a1.39 1.39 0 00.16-1.39l-6.78-15.36a1.58 1.58 0 00.22-.23l10-13.4 8.73.87a1.38 1.38 0 10.36-2.74h-.1zm-24.8 44l-15.84-1.57L3 109.07l9.51-12.75 15.83 1.55 6.31 14.26zM220 104.12L205.38 95l.26-16.14a1.4 1.4 0 00-.65-1.21l-14.83-9.24a1.38 1.38 0 00-1.39-.05l-14.43 7.86L169 73.1a1.38 1.38 0 00-1.38 2.39l5.28 3.08-.26 16.24-14 7.58a1.38 1.38 0 00-.72 1.19l-.28 17.5a1.36 1.36 0 00.65 1.19l14.82 9.25a1.38 1.38 0 00.74.21 1.41 1.41 0 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15-8.89a1.34 1.34 0 011.44 0l8.15 5.09a1.39 1.39 0 01.39 1.88zM78.65 96.86a1.38 1.38 0 01-1.11 1.61L74.8 99h-.24a1.4 1.4 0 01-1.36-1.41 1.38 1.38 0 011.12-1.33l2.68-.53a1.39 1.39 0 011.65 1.13zm-14.73-5.07a1.39 1.39 0 01-.52 1.88 1.32 1.32 0 01-.67.18 1.36 1.36 0 01-1.21-.7l-1.46-2.56a1.39 1.39 0 012.41-1.37zM230 129.69a1.38 1.38 0 01-1.15.63 1.47 1.47 0 01-.76-.23l-2.39-1.57a1.38 1.38 0 111.52-2.31l2.39 1.57a1.38 1.38 0 01.39 1.88z" fill="#9aca3c"/><path d="M219.73 107.72a.61.61 0 01-.62-.61.63.63 0 01.3-.54l9.9-6a.61.61 0 11.83.9.39.39 0 01-.19.12l-9.89 6.06a.65.65 0 01-.33.07zm-1.38-3.21l9.92-6a.62.62 0 00-.65-1l-9.9 6a.62.62 0 10.65 1.05zm-69.93-15.07l.15-11.6a.62.62 0 00-1.24 0l-.14 11.6a.61.61 0 00.6.63.61.61 0 00.62-.6zm-3.54-.22l.14-11.6a.62.62 0 00-.62-.62.61.61 0 00-.61.62l-.14 11.6a.63.63 0 00.6.63.63.63 0 00.63-.62zm-41.1-20.45l.14-11.6a.61.61 0 00-.6-.63.61.61 0 00-.61.61l-.15 11.6a.63.63 0 00.61.63.62.62 0 00.65-.58zm-3.53-.24l.13-11.6a.61.61 0 00-.6-.63.63.63 0 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00.47-.73.62.62 0 00-.68-.48l-2.72.49a.61.61 0 00-.5.71.62.62 0 00.6.51zm131.8 32.88h1.11a.28.28 0 00.31-.25v-3.47h4.7v3.41a.28.28 0 00.25.31.06.06 0 00.06 0h1.12a.27.27 0 00.31-.25v-8.39a.3.3 0 00-.24-.32h-1.19a.3.3 0 00-.31.26v3.42h-4.7v-3.36a.3.3 0 00-.25-.32h-1.17a.28.28 0 00-.31.26v8.39a.28.28 0 00.24.31.14.14 0 00.09 0zm9.95 0h1.1a.29.29 0 00.32-.26v-6l4.83 6.06a.44.44 0 00.39.19h1.1a.28.28 0 00.31-.25v-8.39a.29.29 0 00-.25-.32h-1.17a.28.28 0 00-.31.26v6l-4.81-6.12a.49.49 0 00-.39-.19h-1.09a.3.3 0 00-.31.26v8.38a.29.29 0 00.23.33.11.11 0 00.08 0zM113.21 83.06h1.11a.29.29 0 00.31-.25v-6l4.81 6.07a.44.44 0 00.39.19H121a.29.29 0 00.31-.26v-8.42a.29.29 0 00-.26-.32h-1.16a.3.3 0 00-.31.26v6l-4.82-6.12a.47.47 0 00-.38-.19h-1.12a.28.28 0 00-.31.26v8.39a.3.3 0 00.22.34zm0 10.66h1.11a.3.3 0 00.31-.26V90h4.7v3.4a.29.29 0 00.26.32h1.17a.28.28 0 00.31-.26.06.06 0 000-.06v-8.35a.28.28 0 00-.25-.32h-1.17a.29.29 0 00-.32.26v3.42h-4.7v-3.36a.3.3 0 00-.26-.32h-1.16a.28.28 0 00-.31.26v8.39a.28.28 0 00.25.31.06.06 0 00.06 0zm118.36 45.8h1.1a.29.29 0 00.31-.25v-5.86l2.69 4.4a.42.42 0 00.37.22h.7a.4.4 0 00.37-.22l2.7-4.42v5.82a.28.28 0 00.25.31h1.15a.28.28 0 00.31-.25v-8.43a.28.28 0 00-.24-.32h-1.4a.42.42 0 00-.37.22l-3.08 5.19-3.12-5.19a.42.42 0 00-.37-.22h-1.35a.29.29 0 00-.3.27v8.38a.27.27 0 00.23.32zm14.11 0h3.45a.29.29 0 00.31-.25v-1a.28.28 0 00-.25-.31h-3.48c-.74 0-1-.21-1-1.08v-.26h4.94a.29.29 0 00.31-.25v-1.21c0-1.76-.57-2.78-2.57-2.78h-1.75c-2 0-2.57 1-2.57 2.78v1.54c0 1.78.57 2.79 2.57 2.79zm-.93-4.17V135c0-.87.21-1.07 1-1.07h1.68c.76 0 1 .2 1 1.07v.33zM157 64.53h1.1a.3.3 0 00.32-.26v-3.46h4.7v3.4a.29.29 0 00.25.32h1.18a.28.28 0 00.31-.26v-8.38a.28.28 0 00-.24-.32h-1.2a.28.28 0 00-.31.25v3.43h-4.71v-3.36a.28.28 0 00-.25-.32h-1.17a.27.27 0 00-.3.25.08.08 0 000 .07v8.32a.27.27 0 00.24.32zm0 10.65h1.1a.28.28 0 00.32-.24v-6L163.2 75a.42.42 0 00.38.19h1.12a.28.28 0 00.31-.25v-8.4a.3.3 0 00-.25-.32h-1.17a.3.3 0 00-.31.26v6l-4.81-6.12a.51.51 0 00-.39-.19H157a.29.29 0 00-.31.27v8.38a.28.28 0 00.25.31zM53.49 87.34h1.11a.28.28 0 00.31-.26v-6l4.81 6.1a.49.49 0 00.39.19h1.12a.28.28 0 00.31-.25v-8.4a.28.28 0 00-.24-.32h-1.19a.28.28 0 00-.31.26.06.06 0 000 .06v6L55 78.59a.47.47 0 00-.38-.19h-1.14a.28.28 0 00-.31.25V87a.28.28 0 00.26.3zm28.52-6a.55.55 0 01-.28-.07l-11.49-5.6a.62.62 0 01-.35-.8.62.62 0 01.8-.35h.09l11.5 5.61a.62.62 0 01.29.82.65.65 0 01-.56.35z" fill="#30a74d"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> PAR2 Agonist, EC<sub>50</sub>= 230 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Neurology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5655#track-records" class="trecord trecord-link type-enzymes"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Enzymes</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>ATX Inhibitor, IC50= 55 nM</title><path d="M91.89 79.61a.64.64 0 01-.65-.64V66.8a.64.64 0 01.64-.65.65.65 0 01.64.65V79a.64.64 0 01-.64.64zm32.16-5.22a.64.64 0 00-.63-.66l-2.62-.07a.64.64 0 00-.67.61.65.65 0 00.63.67l2.63.07a.64.64 0 00.66-.61zm0-4a.64.64 0 00-.63-.66l-2.62-.07a.65.65 0 00-.67.62.66.66 0 00.63.67l2.63.07a.65.65 0 00.66-.59zm0-3.51a.64.64 0 00-.63-.66l-2.62-.07a.64.64 0 00-.67.61.66.66 0 00.63.66l2.63.07a.64.64 0 00.66-.61zm0-3.81a.65.65 0 00-.63-.66l-2.62-.06a.65.65 0 100 1.29l2.63.07a.64.64 0 00.66-.62zM88.84 78.78V66.62a.66.66 0 00-.64-.62.65.65 0 00-.65.65v12.13a.65.65 0 00.65.65.65.65 0 00.64-.65zm51 21.34a.64.64 0 00.64-.64l-.11-12.17a.65.65 0 00-.65-.65.66.66 0 00-.64.66l.11 12.17a.65.65 0 00.7.63zm-3.72-.17a.65.65 0 00.65-.65l-.11-12.17a.65.65 0 00-.65-.64.64.64 0 00-.64.65l.11 12.17a.64.64 0 00.64.64zM193 42.64a.66.66 0 00.12-.91l-7.39-9.66a.65.65 0 00-1 .78l7.4 9.66a.62.62 0 00.51.26.73.73 0 00.36-.13zm-3.08 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class="tr-title">Therapy Area:</strong> Inflammation </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5658#track-records" class="trecord trecord-link type-kinases"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Kinases</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>TAK1 Inhibitor, IC50= 5 nM</title><path d="M232.35 88.56l-9.19-16a1.43 1.43 0 00-1.26-.73l-18.18.11a1.46 1.46 0 00-1.26.75l-8.62 15.46-16.61.1-4.49-7.5a1.46 1.46 0 00-2.5 1.49l4.88 8.22a1.48 1.48 0 001.31.73l17.51-.11 8.25 14.41-3.64 6.51a1.45 1.45 0 102.54 1.41l3.58-6.42 17.44-.11a1.46 1.46 0 001.27-.75l9-16.14a1.47 1.47 0 00-.03-1.43zM221.23 104l-16.47.1-8.35-14.54 8.18-14.68 16.46-.11 8.36 14.58zm-7.3 34a1.46 1.46 0 01-1.46 1.46h-7.91l-4.29 7.37a1.49 1.49 0 01-1.27.73 1.57 1.57 0 01-.73-.2 1.47 1.47 0 01-.55-2l4.43-7.59-3.87-6.77a1.46 1.46 0 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<div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5661#track-records" class="trecord trecord-link type-enzymes"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Enzymes</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>sEH Inhibitor, IC50= 2 nM</title><path d="M88.63 111.17a.59.59 0 01-.6-.59l-.1-11.27a.6.6 0 01.59-.6.61.61 0 01.6.59l.1 11.27a.6.6 0 01-.59.6zm-3.44-.17a.6.6 0 00.6-.6l-.1-11.27a.59.59 0 00-.6-.59.59.59 0 00-.59.6l.1 11.27a.6.6 0 00.59.59zm105.57-26.91a.59.59 0 00.59-.6l-.1-11.27a.58.58 0 00-.59-.59.6.6 0 00-.6.6l.1 11.27a.61.61 0 00.6.59zm-3.44-.16a.6.6 0 00.6-.59l-.1-11.26a.6.6 0 00-.6-.6.6.6 0 00-.59.61l.1 11.26a.59.59 0 00.59.59zm-17.5-20.72a.59.59 0 00.59-.6l-.11-12.42a.6.6 0 00-.6-.59.59.59 0 00-.59.6l.11 12.42a.59.59 0 00.6.59zm-20.6-12.44l11-6.46a.6.6 0 10-.61-1l-11 6.46a.59.59 0 00-.21.82.6.6 0 00.51.29.68.68 0 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00-.3.24v5.88l-4.68-5.94a.41.41 0 00-.37-.18h-1.08a.28.28 0 00-.31.25v8.14a.29.29 0 00.27.29zm164.74-26.64H191c2 0 2.85-1.15 2.85-3V89.6c0-1.85-.85-3-2.85-3h-3.11c-2 0-2.85 1.16-2.85 3v2.7c0 1.84.85 3 2.85 3zm0-1.63c-.8 0-1.17-.24-1.17-1.3v-2.81c0-1.08.35-1.31 1.17-1.31H191c.84 0 1.17.23 1.17 1.31v2.81c0 1.06-.37 1.3-1.17 1.3zm12.61-33.18h1.07a.28.28 0 00.31-.25v-3.36h4.56v3.3a.28.28 0 00.24.31h1.15a.27.27 0 00.3-.25v-8.14a.28.28 0 00-.25-.31h-1.14a.27.27 0 00-.3.25v3.33h-4.56v-3.27a.3.3 0 00-.25-.31h-1.13a.27.27 0 00-.3.25v8.14a.28.28 0 00.24.31zm-.18 10.34h1.07a.26.26 0 00.3-.24.06.06 0 000-.06v-5.78l4.68 5.9a.43.43 0 00.37.18h1.09a.27.27 0 00.3-.25v-8.13a.27.27 0 00-.25-.31h-1.13a.27.27 0 00-.3.24v5.88l-4.67-6a.41.41 0 00-.37-.18h-1.08a.28.28 0 00-.31.25v8.14a.27.27 0 00.24.31.08.08 0 00.07 0zm-177.17 33h1.07a.28.28 0 00.3-.25v-5.86l4.68 5.9a.41.41 0 00.37.18h1.08a.28.28 0 00.31-.25V95.4a.28.28 0 00-.25-.3h-1.13a.27.27 0 00-.3.24v5.88l-4.68-5.94a.41.41 0 00-.37-.18h-1.08a.27.27 0 00-.31.25v8.13a.29.29 0 00.23.33z" fill="#0868b1"/><path d="M194.73 68.34l-5.55 3.28-13.8-8-.34-16a1.33 1.33 0 00-.68-1.13L159.65 38a1.31 1.31 0 00-1.35 0L144 46.56a1.35 1.35 0 00-.66 1.19l.28 16.25-13.5 8-.14.11-14-8a1.31 1.31 0 00-1.35 0l-14.4 8.53a1.33 1.33 0 00-.65 1.18L99.94 90l-12.89 7.65-6.65-3.83a1.34 1.34 0 00-1.4 2.27h.09l7.33 4.22a1.29 1.29 0 00.67.18 1.34 1.34 0 00.68-.19l13.6-8 14 8.06a1.33 1.33 0 001.36 0l5.21-3.09a1.34 1.34 0 00.58-1.8 1.35 1.35 0 00-1.81-.58l-.13.08-4.58 2.69L102.76 90l-.32-15.6 12.89-7.64 13.38 7.7.17 8.41a1.33 1.33 0 001.34 1.31 1.33 1.33 0 001.31-1.36l-.17-8.48h.09l13.57-8 14 8a1.39 1.39 0 00.67.17 1.36 1.36 0 00.68-.18l13.88-8.22 14.26 8.23a1.45 1.45 0 00.67.17 1.33 1.33 0 00.68-.18l6.23-3.69a1.34 1.34 0 00-1.37-2.3zm-35.06 3.28l-13.37-7.7-.3-15.46 13-7.7 13.38 7.7.31 15.46zM73.77 81v3.43a1.33 1.33 0 01-1.34 1.33 1.34 1.34 0 01-1.32-1.35v-3.43a1.33 1.33 0 011.34-1.33A1.33 1.33 0 0173.77 81zm-7 13.14a1.34 1.34 0 01-.44 1.86l-7.54 4.37a1.34 1.34 0 01-1.34 0l-14-8.06L35.5 97a1.36 1.36 0 01-.68.18 1.34 1.34 0 01-.69-2.49l8.37-5a1.18 1.18 0 01.59-.32 1.33 1.33 0 011.49.43l13.53 7.79 6.87-4a1.35 1.35 0 011.83.5zm182.89-20.32a1.35 1.35 0 00-.68-1.14l-14.71-8.48a1.36 1.36 0 00-1.35 0l-13.38 7.94-.18-.13-6.2-3.57a1.35 1.35 0 10-1.34 2.34l6.07 3.49.33 16.63a1.34 1.34 0 00.7 1.12l14.71 8.48a1.31 1.31 0 001.35 0l14.36-8.5a1.34 1.34 0 00.66-1.2zm-15.39 24l-13.35-7.7-.31-15.46 13-7.72L247 74.61l.31 15.46zm-213.86-2a1.34 1.34 0 01-1.78.66l-5-2.3L3 105.6l7.34 13.47 7.76-1.61a1.34 1.34 0 01.54 2.63l-8.73 1.8a1.24 1.24 0 01-.27 0 1.35 1.35 0 01-1.18-.7L.16 106a1.35 1.35 0 01.2-1.55l12-12.93a1.34 1.34 0 011.54-.3L19.75 94a1.34 1.34 0 01.66 1.77zm9 11.16l-.5 3.35a1.34 1.34 0 01-1.32 1.15h-.19a1.33 1.33 0 01-1.14-1.49l.5-3.35a1.34 1.34 0 012.67.25.5.5 0 010 .12z" fill="#2aa1db"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> sEH Inhibitor, IC<sub>50</sub>= 2 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Inflammation </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5665#track-records" class="trecord trecord-link type-kinases"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Kinases</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>BTK Inhibitor, IC50= 2 nM</title><path d="M104.75 120.6a.33.33 0 01-.14 0 .61.61 0 01-.45-.74l2.66-11.24a.61.61 0 01.71-.49.6.6 0 01.49.71v.07l-2.66 11.24a.61.61 0 01-.61.45zm-2.75-1.47l2.66-11.24a.62.62 0 00-1.18-.35.13.13 0 000 .06l-2.67 11.24a.62.62 0 00.46.74h.14a.6.6 0 00.59-.45zm21.2-37.59a.61.61 0 000-.86l-8.2-8.13a.62.62 0 10-.86.88l8.17 8.12a.56.56 0 00.43.18.57.57 0 00.46-.19zm-2.61 2.37a.6.6 0 000-.86l-8.18-8.13a.62.62 0 00-.87 0 .63.63 0 000 .87l8.17 8.13a.67.67 0 00.44.18.62.62 0 00.44-.19zM40.85 90a.61.61 0 00.38-.78L37 77.2a.6.6 0 00-.78-.37.61.61 0 00-.38.78l4.23 12a.61.61 0 00.58.42zm20.71-3.42l3.34-12.27a.61.61 0 10-1.16-.4v.08l-3.36 12.26a.62.62 0 00.43.76H61a.62.62 0 00.56-.44zm-44.81-1.86l8.51-9.87a.62.62 0 00-.93-.81l-8.51 9.88a.61.61 0 000 .86.67.67 0 00.42.16.58.58 0 00.51-.22zm16.93 13.57a.62.62 0 00-.47-.73L20.34 95a.61.61 0 00-.3 1.18h.06L33 98.76h.12a.61.61 0 00.56-.47zM193.91 86l10.9-6.54a.61.61 0 10-.64-1L193.27 85a.62.62 0 00-.21.84.63.63 0 00.85.21zm11.65-18.79a.6.6 0 00-.24-.83l-11.39-6.33a.62.62 0 00-.84.24.61.61 0 00.24.83l11.4 6.35a.61.61 0 00.3.08.6.6 0 00.53-.32zm-22.08 13.27a.61.61 0 00.61-.61L184 66.78a.61.61 0 00-.61-.6.61.61 0 00-.61.61l.07 13.11a.61.61 0 00.61.62zM227.72 83l6.89-4.15a.61.61 0 10-.63-1l-6.9 4.15a.61.61 0 00-.21.84.6.6 0 00.53.3.62.62 0 00.32-.09zm7.67-16.35a.63.63 0 00-.24-.84l-8.58-4.75a.61.61 0 00-.83.23.62.62 0 00.23.84l8.58 4.76a.61.61 0 00.3.08.63.63 0 00.52-.32zm-15.67-7.06h1.1a.3.3 0 00.31-.26v-6l4.79 6.05a.47.47 0 00.38.19h1.11a.28.28 0 00.31-.26v-8.26a.28.28 0 00-.24-.32h-1.17a.3.3 0 00-.31.27.13.13 0 000 .06v6L221.2 51a.44.44 0 00-.38-.18h-1.11a.27.27 0 00-.31.25v8.32a.28.28 0 00.27.3zM93.29 84.16h1.1a.3.3 0 00.31-.26V78l4.79 6a.42.42 0 00.38.19H101a.28.28 0 00.31-.25V75.6a.28.28 0 00-.24-.32h-1.19a.27.27 0 00-.3.25v6.07l-4.79-6.08a.49.49 0 00-.39-.19h-1.11a.28.28 0 00-.31.25v8.34a.28.28 0 00.24.32h.07zm37.55 41.2h1.09a.28.28 0 00.31-.24v-5.8l2.67 4.38a.44.44 0 00.38.21h.71a.44.44 0 00.37-.21l2.68-4.4v5.79a.28.28 0 00.24.31h1.15a.27.27 0 00.31-.25.06.06 0 000-.06v-8.29a.28.28 0 00-.25-.31h-1.4a.44.44 0 00-.37.21l-3.06 5.17-3.11-5.17a.44.44 0 00-.37-.21h-1.33a.28.28 0 00-.31.26v8.29a.28.28 0 00.24.31h.05zm14 0h3.44a.28.28 0 00.31-.24v-1a.28.28 0 00-.25-.31h-3.44c-.74 0-1-.2-1-1.08v-.25h4.91a.28.28 0 00.31-.25v-1.2c0-1.75-.57-2.76-2.56-2.76h-1.74c-2 0-2.55 1-2.55 2.76v1.53c0 1.8.57 2.8 2.55 2.8zm-.92-4.15v-.27c0-.86.21-1 1-1h1.67c.75 0 1 .19 1 1v.34zm-8.83-82.65h3.18c2 0 2.92-1.18 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0 01-.38.06 1.35 1.35 0 01-1-.4L64.3 91.42a1.34 1.34 0 01-.4.07l-17.69.19a1.24 1.24 0 01-.33 0L35.39 103.9a1.36 1.36 0 01-1 .48.82.82 0 01-.27 0L17 101a1.4 1.4 0 01-1-.88l-5.92-16.35a1.37 1.37 0 01.25-1.36l11.07-13a1.37 1.37 0 011.31-.45l16.65 3.28L46.21 67A1.37 1.37 0 1148 69.08l-.11.09-6.69 5.11L46.52 89l16.7-.19 4.09-15.23-6-4.27A1.38 1.38 0 0162.9 67l6.1 4.37 16.25-4.69a1.37 1.37 0 011.34.33l4.28 4.2a1.37 1.37 0 01-.07 1.94 1.38 1.38 0 01-1.85 0l-3.71-3.63L70 73.94l-4.06 15.27L77 100.05l15.3-4.42 2-7.47a1.37 1.37 0 112.68.58v.13l-2 7.73.37.36 13.17 9.79 3.2-.93a1.38 1.38 0 011.6.94zM43.88 89.71l-5.4-14.87L23 71.77 12.87 83.56l5.4 14.9 15.51 3.07zM155.55 59L149 63l-11.71-10.24-.1-9.36a1.39 1.39 0 00-1.38-1.4 1.39 1.39 0 00-1.36 1.39l.1 9-14.88 4.7h-.16l-9.43-12.92 9.15-12.71 8 2.67a1.37 1.37 0 00.88-2.6l-8.94-3a1.37 1.37 0 00-1.53.52l-10.37 14.32a1.4 1.4 0 000 1.61l10.35 14.14-4 15.11-7.08 2.06a1.37 1.37 0 00.38 2.69 1.58 1.58 0 00.38 0l7.67-2.21a1.4 1.4 0 00.71-.51 1.37 1.37 0 00.4-.66l4.26-15.77 15.32-4.84L148 65.71a1.36 1.36 0 00.9.34 1.29 1.29 0 00.72-.21l7.38-4.53a1.39 1.39 0 00.29-1.93 1.36 1.36 0 00-1.74-.38zm61.89 27a1.36 1.36 0 01-1.85.59l-7-3.62-13.86 8.53a1.43 1.43 0 01-.73.2 1.34 1.34 0 01-.65-.17l-15-8.26a1.39 1.39 0 01-.71-1.19l-.17-17.37-6.53-3.58a1.37 1.37 0 011.22-2.46l.1.06 7.11 3.91.1.07 13.47-8.3a1.36 1.36 0 011.38 0l14.55 8 5.82-3.57a1.37 1.37 0 011.44 2.34L210 64.91l.16 15.81 6.67 3.4a1.36 1.36 0 01.56 1.85zm-10-5.53l-.16-15.82-13.6-7.49-13.48 8.28.16 15.81 13.64 7.5zm32.36-17.26a1.37 1.37 0 00-.71-1.19l-6.25-3.41a1.37 1.37 0 10-1.33 2.4l5.55 3.07.16 15.83-5.91 3.65a1.37 1.37 0 001.44 2.33l6.6-4.1a1.33 1.33 0 00.65-1.18z" fill="#ef4379"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> BTK Inhibitor, IC<sub>50</sub>= 2 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5668#track-records" class="trecord trecord-link type-kinases"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Kinases</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>BTK Inhibitor, IC50= 60 nM (1h)</title><path d="M135.24 33.62l2.54-3.72 11.31 9.25zm-56 27.12A.72.72 0 0080 60l-.12-13.77a.73.73 0 00-.73-.73.74.74 0 00-.73.74L78.51 60a.73.73 0 00.73.73zM75 60.55a.74.74 0 00.73-.74L75.62 46a.71.71 0 00-.71-.72.74.74 0 00-.73.74l.12 13.78a.73.73 0 00.73.72zm58 23.34a.73.73 0 00.72-.74l-.12-13.77a.73.73 0 00-.73-.73.73.73 0 00-.73.72l.12 13.77a.73.73 0 00.73.73zm-4.21-.19a.72.72 0 00.72-.74l-.12-13.78a.72.72 0 00-.72-.72.74.74 0 00-.73.74l.18 13.8a.73.73 0 00.73.7zm60.83-23a.73.73 0 00.73-.74l-.12-13.77a.73.73 0 00-.73-.73.74.74 0 00-.73.74L189 60a.73.73 0 00.73.73zm-4.2-.19a.74.74 0 00.73-.74L186.09 46a.74.74 0 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01-.73.71l-3-.08a.73.73 0 010-1.46l3 .08a.73.73 0 01.71.75zm56.73-15.36l-1.55 2.54a.74.74 0 01-.61.36.7.7 0 01-.38-.11.73.73 0 01-.25-1l1.55-2.54a.73.73 0 011.22.76z" fill="#ef4379"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> BTK Inhibitor, IC<sub>50</sub>= 60 nM (1h) </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5671#track-records" class="trecord trecord-link type-kinases"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Kinases</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>MerTK Inhibitor, IC50= 5 nM</title><path d="M61.51 76.38a.63.63 0 01-.33-.09l-11.06-6.85a.62.62 0 010-.88.63.63 0 01.71-.16l11.06 6.85a.63.63 0 01.2.86.6.6 0 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01-1 1.73l-8.36 2.3a1.65 1.65 0 01-.38 0 1.4 1.4 0 01-1.16-.62L5.24 81.29a1.4 1.4 0 01.06-1.65l4.75-6.12a1.41 1.41 0 112.22 1.73l-4.14 5.31 9.19 13.58 7.4-2a1.41 1.41 0 011.7.97zm101.5 21.6l-3.25.07a1.41 1.41 0 000 2.81l3.25-.07a1.41 1.41 0 00.1-2.81h-.13zm-10.59-21.82l-5.65 4.32-5.74-3a1.42 1.42 0 00-1.88.66 1.4 1.4 0 00.57 1.83l6.09 3.2 3.35 9.51a1.39 1.39 0 001.32.94 1.26 1.26 0 00.47-.08 1.41 1.41 0 00.86-1.79l-3.21-9.08 5.49-4.27a1.41 1.41 0 00-1.71-2.24zM245 61.21l-3.24 17.48a1.4 1.4 0 01-.89 1L224.18 86a1.4 1.4 0 01-1.39-.24l-13.42-11.24a1.29 1.29 0 01-.16-.17l-15.6 5.86-.25.07-3.21 17.24a1.38 1.38 0 01-.89 1l-16.66 6.27a1.33 1.33 0 01-.49.09 1.35 1.35 0 01-.9-.33L158.52 94l-16.34 6.12-2.65 9.17a1.4 1.4 0 01-1.35 1 1.74 1.74 0 01-.39 0 1.41 1.41 0 01-1-1.73l2.71-9.41-5.69-4.15a1.4 1.4 0 111.61-2.29l6.4 4.53 15.61-5.86 3.14-16.83a1.37 1.37 0 01.88-1l16.67-6.27a1.4 1.4 0 011.39.23L192.06 78a1.4 1.4 0 01.55-.38l16.64-6.24 2.81-15.15-9.14-7.67a1.42 1.42 0 01-.08-2 1.4 1.4 0 011.88-.16l9.18 7.68a1.37 1.37 0 01.17.17l15.62-5.85a1.38 1.38 0 011.39.24l13.42 11.23a1.39 1.39 0 01.5 1.34zm-54.5 19.1l-12.19-10.19-15.15 5.68-2.95 15.9 12.16 10.19 15.15-5.68zm51.6-18.81l-12.19-10.19L214.76 57l-2.95 15.89L224 83.08l15.15-5.68zM86.64 94.17l-6 3.14-14-8.49.45-15.63a1.38 1.38 0 00-.66-1.19l-15.24-9.26a1.39 1.39 0 00-1.38 0L34.07 71l-7.16-2.69a1.41 1.41 0 00-1 2.61l7.32 2.76-.23 8.71a1.4 1.4 0 001.37 1.43 1.38 1.38 0 001.42-1.34l.25-9.37 14.35-7.56 13.85 8.36-.46 15.85-14.28 7.55-7-4.18a1.41 1.41 0 00-1.5 2.34.41.41 0 00.11.07l7.62 4.61a1.41 1.41 0 001.38 0l15.73-8.25a.9.9 0 00.2-.14l13.86 8.36a1.43 1.43 0 00.73.2 1.33 1.33 0 00.65-.16l6.66-3.5a1.41 1.41 0 00-1.31-2.49zm9.92-16.64a1.41 1.41 0 00-1.4 1.38l-.06 4.24a1.4 1.4 0 001.38 1.42 1.42 1.42 0 001.41-1.38L98 79a1.42 1.42 0 00-1.38-1.45z" fill="#ef4379"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> MerTK Inhibitor, IC<sub>50</sub>= 5 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5674#track-records" class="trecord trecord-link type-enzymes"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Enzymes</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>KMO Inhibitor, IC50= 14 nM</title><path d="M201.48 112.46a.63.63 0 01-.39-1.12l9.43-7.17a.63.63 0 01.76 1l-9.43 7.17a.63.63 0 01-.37.12zm2.72 2.62l9.43-7.16a.63.63 0 00.12-.88.63.63 0 00-.88-.12l-9.43 7.16a.63.63 0 00.76 1zm-41.37-26.76a.61.61 0 00.52-.7l-1.51-11.71a.62.62 0 00-.7-.55.64.64 0 00-.55.71l1.51 11.73a.63.63 0 00.62.52zm-3.55.66a.64.64 0 00.52-.71l-1.51-11.73a.62.62 0 00-1.23.18l1.51 11.73a.63.63 0 00.62.53zm-91.09 12.83A.62.62 0 0068 101l-11.29-6.64a.63.63 0 10-.71 1.06L67.33 102a.64.64 0 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5.29-3.18-5.29a.41.41 0 00-.38-.22H.34a.28.28 0 00-.31.25.08.08 0 000 .07v8.48a.28.28 0 00.26.31zm14.38 0h3.52a.29.29 0 00.32-.26.13.13 0 000-.06V131a.29.29 0 00-.25-.33h-3.56c-.76 0-1-.2-1-1.1v-.26h5a.27.27 0 00.31-.25v-1.23c0-1.8-.58-2.84-2.62-2.84h-1.72c-2 0-2.62 1-2.62 2.84v1.57c0 1.83.58 2.85 2.62 2.85zm-1-4.25v-.35c0-.88.21-1.08 1-1.08h1.72c.77 0 1 .2 1 1.08v.35zm9.75 4.25h3.26c2.09 0 3-1.21 3-3.14v-2.83c0-1.94-.9-3.14-3-3.14h-3.21c-2.09 0-3 1.21-3 3.14v2.83c0 1.89.9 3.14 3 3.14zm0-1.71c-.84 0-1.24-.25-1.24-1.37v-2.95c0-1.13.37-1.38 1.24-1.38h3.26c.88 0 1.24.25 1.24 1.38v2.95c0 1.12-.39 1.37-1.24 1.37zm149.89-16.7h1.11a.29.29 0 00.32-.26v-6l2.74 4.49a.41.41 0 00.38.22h.71a.41.41 0 00.38-.22l2.75-4.5v5.92a.28.28 0 00.24.32h1.19a.31.31 0 00.32-.27V105a.31.31 0 00-.26-.33h-1.41a.44.44 0 00-.39.22l-3.14 5.29-3.18-5.29a.43.43 0 00-.37-.22h-1.37a.3.3 0 00-.32.27v8.54a.29.29 0 00.25.33zm14.37 0h3.52a.29.29 0 00.32-.26v-1a.3.3 0 00-.26-.32h-3.54c-.76 0-1-.21-1-1.1v-.26h5a.28.28 0 00.31-.26v-1.24c0-1.8-.58-2.83-2.62-2.83h-1.78c-2 0-2.62 1.05-2.62 2.83v1.6c0 1.84.58 2.86 2.62 2.86zm-.95-4.26v-.33c0-.88.21-1.09 1-1.09h1.71c.77 0 1 .21 1 1.09v.33zm-58.59 17.77h2.49c2.22 0 3-1 3-2.71s-.81-2.38-2.73-2.54l-2.83-.22c-.84-.06-1.17-.24-1.17-.95s.34-1 1.32-1h2.28c.82 0 1.16.29 1.23 1a.29.29 0 00.32.32h1.14a.28.28 0 00.31-.25.19.19 0 000-.08c-.08-1.83-1-2.75-3-2.75h-2.31c-2.21 0-3 1-3 2.71s.78 2.35 2.73 2.5l2.82.22c.85.07 1.18.27 1.18 1s-.34 1-1.31 1h-2.48c-.82 0-1.16-.28-1.24-1a.29.29 0 00-.32-.33h-1.12a.28.28 0 00-.31.24.31.31 0 000 .1c.15 1.82 1.04 2.74 3.05 2.74zm28.6-54.16h3.25c2.1 0 3-1.22 3-3.14v-2.84c0-1.94-.9-3.14-3-3.14h-3.25c-2.1 0-3 1.21-3 3.14v2.84c.05 1.95.95 3.14 3.05 3.14zm0-1.73c-.85 0-1.24-.24-1.24-1.35v-3c0-1.13.36-1.37 1.24-1.37h3.25c.89 0 1.24.24 1.24 1.37v3c0 1.11-.39 1.36-1.24 1.36zm81.82-19.74h1.12a.28.28 0 00.31-.26.09.09 0 000-.07V47.9h3.41a.29.29 0 00.32-.26v-1a.31.31 0 00-.26-.33h-3.47v-2h5.29a.3.3 0 00.32-.26V43a.29.29 0 00-.26-.32h-6.78a.31.31 0 00-.32.27v8.54a.3.3 0 00.31.29zm-72.41 85.36h2.83c2.09 0 3-1.22 3-3.15v-.25c0-.16-.12-.25-.32-.25h-1.13a.28.28 0 00-.31.26v.31c0 1.11-.39 1.36-1.24 1.36h-2.83c-.84 0-1.24-.25-1.24-1.36v-3c0-1.13.37-1.37 1.24-1.37h2.83c.87 0 1.24.24 1.24 1.37v.2c0 .13.11.22.31.22h1.13a.28.28 0 00.32-.25v-.11c0-1.94-.9-3.14-3-3.14h-2.83c-2.09 0-3 1.22-3 3.14v2.83c.05 1.97.95 3.19 3.05 3.19zm7.64 0h1.05a.31.31 0 00.32-.27v-9.23a.3.3 0 00-.26-.32h-1.11a.3.3 0 00-.32.26.13.13 0 000 .06v9.18a.29.29 0 00.25.32zM200 32.73h2.82c2.1 0 3-1.21 3-3.14v-.26c0-.15-.11-.25-.31-.25h-1.13a.31.31 0 00-.32.27v.3c0 1.12-.39 1.36-1.24 1.36H200c-.85 0-1.24-.24-1.24-1.36v-3c0-1.13.37-1.37 1.24-1.37h2.82c.88 0 1.24.24 1.24 1.37v.21c0 .13.12.22.32.22h1.13a.3.3 0 00.32-.26.2.2 0 000-.07c0-2-.89-3.14-3-3.14H200c-2.09 0-3 1.21-3 3.14v2.83c0 1.94.91 3.15 3 3.15zm7.64 0h1a.28.28 0 00.31-.26.06.06 0 000-.06v-9.17a.3.3 0 00-.24-.33h-1.12a.31.31 0 00-.32.27v9.23a.29.29 0 00.26.32zm-82.21 63.58h1.13a.29.29 0 00.31-.27.06.06 0 000-.06v-6.07l4.92 6.2a.45.45 0 00.39.2h1.13a.29.29 0 00.32-.27.06.06 0 000-.06v-8.49a.28.28 0 00-.25-.32h-1.18a.29.29 0 00-.31.27v6.17L127 87.38a.47.47 0 00-.39-.2h-1.14a.29.29 0 00-.32.26V96a.3.3 0 00.27.32zm48.14 0h1.13a.31.31 0 00.3-.31v-6.09l4.91 6.2a.46.46 0 00.39.2h1.14a.31.31 0 00.32-.27v-8.55a.3.3 0 00-.26-.32h-1.19a.29.29 0 00-.31.27v6.12l-4.92-6.23a.46.46 0 00-.39-.2h-1.14a.29.29 0 00-.31.27V96a.29.29 0 00.26.32zm22.23 26.45h3.25c2.09 0 3-1.22 3-3.14v-2.84c0-1.93-.9-3.14-3-3.14h-3.25c-2.1 0-3 1.22-3 3.14v2.84c0 1.92.92 3.14 3 3.14zm0-1.72c-.85 0-1.25-.25-1.25-1.36v-3c0-1.13.37-1.38 1.25-1.38h3.25c.88 0 1.24.25 1.24 1.38v3c0 1.11-.39 1.36-1.24 1.36zm37.93 1.31H237c2.1 0 3-1.22 3-3.15v-2.83c0-1.94-.9-3.14-3-3.14h-3.23c-2.1 0-3 1.21-3 3.14v2.83c0 1.93.9 3.15 3 3.15zm0-1.73c-.85 0-1.24-.24-1.24-1.35v-3c0-1.12.37-1.37 1.24-1.37H237c.89 0 1.24.25 1.24 1.37v3c0 1.11-.39 1.36-1.24 1.36zm8.24 1.73h1.12a.29.29 0 00.32-.27.06.06 0 000-.06v-3.47h4.84V122a.28.28 0 00.25.32h1.2a.3.3 0 00.32-.27v-8.57a.28.28 0 00-.25-.32h-1.2a.3.3 0 00-.32.26v3.49h-4.79v-3.43a.3.3 0 00-.26-.32H242a.29.29 0 00-.32.25V122a.29.29 0 00.23.34zM94.76 112.09h1.1a.3.3 0 00.32-.26v-6.13l4.92 6.19a.46.46 0 00.39.2h1.18a.28.28 0 00.31-.26.06.06 0 000-.06v-8.49a.3.3 0 00-.24-.33h-1.22a.3.3 0 00-.32.27.06.06 0 000 .06v6.1l-4.91-6.23a.47.47 0 00-.39-.2h-1.14a.3.3 0 00-.32.26v8.56a.3.3 0 00.26.32z" fill="#0868b1"/><path d="M179.61 99.89l-.05 2.57a1.41 1.41 0 01-1.4 1.38 1.41 1.41 0 01-1.38-1.44v-2.56a1.39 1.39 0 011.39-1.38 1.41 1.41 0 011.44 1.43zM235 52.3l-13.24 10.11 2.36 17a1.41 1.41 0 01-.53 1.31L210.09 91l2 15 15.74 6.46a1.41 1.41 0 01-.52 2.71 1.61 1.61 0 01-.53-.1l-16.52-6.8a1.43 1.43 0 01-.86-1.12l-2.1-16.05-15-6.43-6.29 4.67a1.38 1.38 0 01-.83.28 1.41 1.41 0 01-.85-2.54l6.58-4.88-2.28-16.47a1.41 1.41 0 01.53-1.31l13.26-10.09-2.35-17a1.41 1.41 0 112.79-.41l2.34 16.95 14.8 6.38 13.35-10.18A1.41 1.41 0 01235 52.3zM221.21 79L219 62.9l-14.9-6.39-12.64 9.65 2.22 16.07 14.9 6.39zm-148 20.36l-.07 16.15 15.47 4.79 3.78-5.13a1.4 1.4 0 012.26 1.66l-4.37 5.94a1.41 1.41 0 01-1.13.58 1.16 1.16 0 01-.42-.07l-17-5.28-14.83 8.29a1.64 1.64 0 01-.69.18 1.4 1.4 0 01-.69-.19l-14.72-8.39-7.4 4.11a1.38 1.38 0 01-2.06-1.26 1.41 1.41 0 01.68-1.18l7.21-4 .07-16.92a1.43 1.43 0 01.7-1.21l15.56-8.69a1.41 1.41 0 011.38 0L71.38 97l17.44-5.76a1.4 1.4 0 011.57.5l4.3 5.82a1.41 1.41 0 01-2.27 1.67l-3.67-5zm-3 16.23l.08-16-14-8-14.16 7.9-.07 15.9 14.08 8zm49.91-8.44l5-6.7a1.41 1.41 0 00-2.25-1.69l-5.19 6.94h-9.53a1.41 1.41 0 000 2.81h9.52l5.55 7.53a1.41 1.41 0 102.31-1.61v-.06zm48.88-18L161.51 86a1.42 1.42 0 00-1.38.17l-14 10.44-8.3-3a1.41 1.41 0 00-.94 2.65l8.44 3 .09 16.12-8.47 2.62a1.41 1.41 0 00.41 2.76 1.14 1.14 0 00.41-.07l9.15-2.8 14.56 8.31a1.41 1.41 0 001.54-2.36l-.14-.08-14.66-8.38-.09-16.82 13.09-9.71 6.76 2.77A1.41 1.41 0 10169 89.1z" fill="#2aa1db"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> KMO Inhibitor, IC<sub>50</sub>= 14 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5678#track-records" class="trecord trecord-link type-protein"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Protein Protein Interaction</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>ATAD2 Inhibitor, IC50= 25 nM</title><path d="M47.25 93.12l-6.68-3.67a1 1 0 00-.3-.11l1.49-14.6h-3.21l1.25 14.58a1.11 1.11 0 00-.43.15l-11.74 7.28a.1.1 0 00-.05 0l-13.21-7.3a1.2 1.2 0 00-1.2 0L.56 97.29A1.22 1.22 0 000 98.35l.6 15.07a1.19 1.19 0 00.62 1l13.21 7.26a1.13 1.13 0 00.57.15 1.18 1.18 0 00.63-.18l12.6-7.81a1.19 1.19 0 00.57-1.06l-.55-13.61L40 91.87l6.1 3.33a1.19 1.19 0 001.15-2.08zM15 119.27l-12-6.62L2.41 99l11.41-7.08 12 6.6.55 13.7zM166.42 45a1.19 1.19 0 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12.24-3.79 7.21a1.19 1.19 0 00.47 1.61 1.22 1.22 0 00.56.14 1.2 1.2 0 001-.62l3.92-7.13 14.09.06a1.18 1.18 0 001-.6l7.4-13 9.6.11a1.19 1.19 0 000-2.38l-10.11-.1-6.65-11.89zm-9 37.68h-13.44l-6.69-12 6.8-11.91 13.44.05 6.69 12zm87-80.1l-9.3 1.58L210 24.91a1.17 1.17 0 00-1-.61l-14.83-.12a1.2 1.2 0 00-1 .59l-7.53 13.07a1.18 1.18 0 00-.12.36l-9.78-1.66v3.21l9.78-1.13a1.38 1.38 0 00.13.39l7.3 13.19a1.21 1.21 0 001 .61l14.83.12a1.21 1.21 0 001-.6l7.53-13.06a1.21 1.21 0 00.16-.59l9.16 1.06zm-18.54 14l-13.44-.11-6.66-12 6.85-11.89 13.46.12 6.65 12z" fill="#555861"/><path d="M84.23 111.59a.53.53 0 01-.53-.51l-.48-11a.54.54 0 01.56-.51.53.53 0 01.5.47l.48 11a.54.54 0 01-.51.56zm-78.9 0a.53.53 0 00.51-.55l-.32-11a.53.53 0 00-.5-.56.52.52 0 00-.56.5v.09l.32 11a.53.53 0 00.53.52zm8.82 5.5a.54.54 0 01-.28-1l9.62-5.91a.54.54 0 01.74.11.53.53 0 01-.11.75h-.08L14.43 117a.57.57 0 01-.28.08zm9.32-16.24a.45.45 0 01-.25-.07l-9.94-5.52a.54.54 0 11.52-1l9.94 5.52a.54.54 0 01.19.73.53.53 0 01-.46.26zm114.53 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0-2.56-1.02-2.56-2.66zm5.29 1.2c.71 0 1-.21 1-1.15v-2.5c0-1-.3-1.16-1-1.16h-2.76c-.73 0-1 .21-1 1.16v2.5c0 1 .32 1.15 1 1.15zm-5.21 24.41v-2.38c0-1.64.76-2.67 2.54-2.67h2.38c1.77 0 2.53 1 2.53 2.67a.24.24 0 01-.21.28h-1c-.17 0-.27-.08-.27-.19v-.17c0-.95-.31-1.16-1.05-1.16h-2.38c-.73 0-1.05.21-1.05 1.16v2.5c0 1 .33 1.15 1.05 1.15h2.38c.72 0 1.05-.21 1.05-1.15V105a.25.25 0 01.21-.28h1c.17 0 .26.08.26.21v.22c0 1.63-.76 2.65-2.53 2.65h-2.38c-1.8.02-2.56-1-2.56-2.63zm8.74 2.38V99.8a.25.25 0 01.21-.28h.93a.25.25 0 01.27.23v7.8a.24.24 0 01-.21.27h-.94a.24.24 0 01-.26-.22zm-42-39v-7.13a.25.25 0 01.21-.28h1a.25.25 0 01.26.23v2.94h4.06v-2.89a.25.25 0 01.21-.28h1a.25.25 0 01.27.23v7.22a.25.25 0 01-.22.27h-1a.24.24 0 01-.26-.22v-2.98h-4.06v2.93a.24.24 0 01-.21.27h-1a.24.24 0 01-.26-.22zm8.56 0v-7.13a.25.25 0 01.21-.28h1a.42.42 0 01.34.17l4.15 5.26v-5.15a.25.25 0 01.21-.28h1a.26.26 0 01.28.22v7.23a.25.25 0 01-.22.27h-1a.42.42 0 01-.33-.16l-4.15-5.23v5.12a.25.25 0 01-.22.27h-1a.23.23 0 01-.26-.23l-.01-.04zm21.39-26.43V35a.25.25 0 01.22-.27h1a.23.23 0 01.27.21v3h4.06V35a.24.24 0 01.21-.27h1a.23.23 0 01.27.21v7.23a.23.23 0 01-.21.27h-1a.24.24 0 01-.26-.22.06.06 0 010-.06v-2.92h-4v2.92a.23.23 0 01-.21.27h-1a.25.25 0 01-.27-.23v-.05zm8.59 0V35a.24.24 0 01.21-.27h1a.39.39 0 01.34.16l4.15 5.27V35a.24.24 0 01.21-.27h1a.23.23 0 01.27.21v7.23a.23.23 0 01-.21.27h-1a.4.4 0 01-.33-.17L168.4 37v5.12a.23.23 0 01-.21.27h-1a.25.25 0 01-.23-.26zm-71.06 93.47v-7.18a.24.24 0 01.21-.27h1.21a.37.37 0 01.32.18l2.69 4.47 2.67-4.47a.38.38 0 01.32-.18h1.15a.25.25 0 01.27.21.13.13 0 010 .06v7.18a.24.24 0 01-.21.27h-1a.25.25 0 01-.27-.22v-5.06l-2.32 3.8a.37.37 0 01-.32.19H100a.35.35 0 01-.32-.19l-2.33-3.8v5a.24.24 0 01-.21.27h-1a.25.25 0 01-.26-.24s-.03-.02-.02-.02zm10.21-2.16v-1.32c0-1.52.47-2.38 2.21-2.38h1.51c1.73 0 2.22.88 2.22 2.38v1a.26.26 0 01-.22.28h-4.33v.22c0 .75.2.95.84.95h3a.25.25 0 01.27.22v.85a.24.24 0 01-.21.27h-3c-1.8-.04-2.29-.9-2.29-2.47zm4.53-1.17V132c0-.75-.19-.92-.84-.92h-1.43c-.65 0-.83.17-.83.92v.28zm2.6 1v-2.37c0-1.65.76-2.67 2.54-2.67h2.74c1.78 0 2.54 1 2.54 2.67v2.37c0 1.63-.76 2.66-2.54 2.66h-2.74c-1.78 0-2.54-1-2.54-2.67zm5.28 1.21c.72 0 1-.21 1-1.15v-2.51c0-.95-.3-1.15-1-1.15h-2.74c-.75 0-1.06.2-1.06 1.15v2.51c0 .95.34 1.15 1.06 1.15zm110.41-92.3V35a.25.25 0 01.22-.27h1a.37.37 0 01.33.16l4.15 5.27V35a.23.23 0 01.22-.27h1a.24.24 0 01.27.21v7.23a.24.24 0 01-.21.27h-1a.4.4 0 01-.33-.17L230.39 37v5.12a.24.24 0 01-.21.27h-1a.26.26 0 01-.28-.22v-.06zm8.75 0V35a.24.24 0 01.21-.27h1a.23.23 0 01.27.21v3h4.06V35a.24.24 0 01.21-.27h1a.23.23 0 01.27.21v7.23a.23.23 0 01-.21.27h-1a.24.24 0 01-.26-.22.06.06 0 010-.06v-2.92h-4.06v2.92a.23.23 0 01-.21.27h-1a.24.24 0 01-.26-.22.06.06 0 010-.06zm8.36 3.76v-.57a.21.21 0 01.11-.19l2.49-1.54c.48-.29.59-.38.59-.68s-.16-.51-.64-.51h-1.07c-.45 0-.61.1-.61.67a.14.14 0 01-.12.16h-.59c-.1 0-.16 0-.16-.09v-.09c0-1 .32-1.56 1.48-1.56h1.09c1.08 0 1.48.48 1.48 1.31s-.31 1-1.18 1.49l-1.43.86h2.43a.14.14 0 01.15.12v.57a.14.14 0 01-.12.16h-3.74A.15.15 0 01246 46z" fill="#121a22"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> ATAD2 Inhibitor, IC<sub>50</sub>= 25 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5681#track-records" class="trecord trecord-link type-protein"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Protein Protein Interaction</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>Mcl-1 Inhibitor, IC50= <3 nM</title><path d="M155.24 116.71a.58.58 0 01-.55-.43L152.18 106a.57.57 0 011.1-.27l2.51 10.27a.58.58 0 01-.41.68zm3.31-.61a.57.57 0 00.41-.68l-2.51-10.27a.56.56 0 00-1.1.23l2.51 10.27a.56.56 0 00.55.42zm-41.27-11a.56.56 0 00.5-.62l-1.1-10.52a.56.56 0 00-.6-.5.56.56 0 00-.5.62l1.09 10.52a.56.56 0 00.56.5zm3.22-.16a.56.56 0 00.5-.62l-1.09-10.52a.56.56 0 10-1.12.11l1.1 10.52a.56.56 0 00.56.5zm-3.27-60a.57.57 0 00-.19-.77l-9-5.51a.56.56 0 00-.79 0 .57.57 0 000 .8.78.78 0 00.18.11l9 5.52a.52.52 0 00.29.09.56.56 0 00.48-.27zm1.83-2.66a.57.57 0 00-.19-.77l-9-5.51a.56.56 0 00-.77.19.56.56 0 00.19.77l9 5.51a.6.6 0 00.29.08.56.56 0 00.48-.27zM94.23 90.65a.57.57 0 00-.4-.69L83.6 87.27a.55.55 0 00-.69.38.56.56 0 00.38.7l10.22 2.7h.15a.58.58 0 00.57-.4zm1-3.08a.55.55 0 00-.4-.68l-10.24-2.7a.56.56 0 00-.67.43.55.55 0 00.39.66L94.54 88a.33.33 0 00.14 0 .57.57 0 00.54-.43zM71 64.69a.51.51 0 00-.12-.69l-8.28-6a.51.51 0 00-.69.12.48.48 0 00.11.68l8.29 6a.47.47 0 00.66-.07zm-18.35 7.58l1.09-10.43a.49.49 0 10-1-.19.28.28 0 000 .09l-1.07 10.43a.46.46 0 00.39.53h.1a.46.46 0 00.49-.43zm7.47 6l9.68-4.17a.51.51 0 00.21-.67.5.5 0 00-.6-.24l-9.69 4.19a.48.48 0 00-.23.65.47.47 0 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4.41a.54.54 0 00-.4-.67l-3.25-.79a.56.56 0 10-.27 1.09l3.28.81h.13a.56.56 0 00.55-.4zm-1.3 3a.56.56 0 00-.41-.68l-3.28-.8a.54.54 0 00-.65.42.56.56 0 00.41.68l3.28.8a.33.33 0 00.14 0 .55.55 0 00.52-.43z" fill="#121a22"/><path d="M128 28.23V20a1.1 1.1 0 011.1-1.1 1.09 1.09 0 011.1 1.1v8.19a1.11 1.11 0 01-1.11 1.11 1.11 1.11 0 01-1.09-1.07zm25.1 41.37a1.11 1.11 0 001.1 1.11 1.11 1.11 0 001.11-1.11v-5.52a1.11 1.11 0 00-.56-1l-12.17-6.88-.17-.07V43.05a1.09 1.09 0 00-.56-1L137 39.36a1.1 1.1 0 00-1.08 1.92l4.24 2.4v13.1a1.11 1.11 0 001 1.1 1.37 1.37 0 00.29.24l11.62 6.55zm70.14 34.81a1.11 1.11 0 01-1.51.39l-6.78-4-11.61 6.35a1.08 1.08 0 01-1.08 0l-12.1-7a1.09 1.09 0 01-.54-1l.16-12.85-7.49-4.21-14.8 4.21v13a1.11 1.11 0 01-.56.94l-12.17 6.88a1.17 1.17 0 01-1.09 0l-4.14-2.34a1.11 1.11 0 111-2l.12.07 3.6 2 11.07-6.25V86.19l-4.7-2.66a1.11 1.11 0 011.06-1.94l4.72 2.66L178 77.7a1.09 1.09 0 011.08 0l11.58 6.55 12-6.55a1.09 1.09 0 011.08 0l12.09 7a1.08 1.08 0 01.55 1l-.16 13.3 6.65 3.93a1.09 1.09 0 01.37 1.51zm-9.24-5.6l.16-12.47-11-6.41L192 86l-.16 12.48 11 6.41zm16.09 17.27A1.11 1.11 0 00229 115a1.11 1.11 0 00-1.1 1.11v5.65a1.1 1.1 0 001.1 1.1 1.11 1.11 0 001.11-1.1zM138.26 119a1.14 1.14 0 010 1l-7.49 13.78a1.11 1.11 0 01-.81.57l-14.71 2.1-3.06 12.63a1.13 1.13 0 01-.77.81L98 153.7a1.12 1.12 0 01-1.06-.26l-10.22-9.56a1.11 1.11 0 01-.32-1.06l3.24-13.38a1.08 1.08 0 01.77-.8l12.74-3.64 1.22-7.63a1.1 1.1 0 012.19.29.13.13 0 000 .06l-1.25 7.76 9.41 8.8 14.37-2.06 4.47-8.21-3-15.49-11.28-3.86-7.4 4.18a1.11 1.11 0 01-1.12-1.91l7.84-4.43a1.13 1.13 0 01.9-.08l11.67 4 4.24-2.81a1.1 1.1 0 111.28 1.8h-.06l-3.88 2.6zm-25.15 16.85l-9.3-8.7-12.24 3.45-2.93 12.12 9.29 8.7 12.24-3.42zm-20.44-32.73L99 107.5a1.1 1.1 0 001.53-.27 1.1 1.1 0 00-.27-1.53l-5.84-4.05V88.92l5-4.68a1.1 1.1 0 00-1.47-1.65l-5.34 5a1.11 1.11 0 00-.35.8v13.77a1.12 1.12 0 00.41.96zm11.43-30.43a1.11 1.11 0 001.11-1.1v-6.85l11.61-6.55a5.42 5.42 0 001.18-1.35V43.68l4.26-2.41a1.1 1.1 0 10-.88-2 1.39 1.39 0 00-.21.11l-4.82 2.73a1.08 1.08 0 00-.55 1v13.08h-.1l-12.17 6.88a1.11 1.11 0 00-.56.94v7.51a1.11 1.11 0 001.08 1.13zM75 63.64L73.73 76.4a1.09 1.09 0 01-.66.9l-12.81 5.62a1.12 1.12 0 01-.44.09 1.16 1.16 0 01-.65-.2l-11.34-8-9.5 4.19a1.11 1.11 0 01-.89-2l9.74-4.37a1.09 1.09 0 01.24-.07l1.22-12L37.44 51a1.1 1.1 0 01-.38-.83v-14l-11.63-6.61-11 6.7a1.06 1.06 0 01-.58.16 1.1 1.1 0 01-.53-.14L1.07 29.5a1.11 1.11 0 01-.56-.94L0 14.59a1.14 1.14 0 01.52-1L12.26 6.4a1.1 1.1 0 011.11 0l12.23 6.76a1.1 1.1 0 01.57.94l.47 13.6 12.06 6.8a1.09 1.09 0 01.56.93v14.22L50 58.83l12.14-5.33a1.1 1.1 0 011.08.11l11.14 7.85 11.75-6.61a1.1 1.1 0 011.09 1.92zM24.44 27.51L24 14.79 12.86 8.62 2.23 15.13l.47 12.72L13.82 34zm48.41 35.61l-10.39-7.35-11.65 5.1-1.26 12.41 10.39 7.37 11.66-5.1z" fill="#555861"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> Mcl-1 Inhibitor, IC<sub>50</sub>= <3 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Oncology </div> </div> </div> <div class="tr-overlay"></div> </a> </div> <div class="tr-slide"> <a href="https://www.x-chemrx.com/del-track-record/?tr=5683#track-records" class="trecord trecord-link type-enzymes"> <div class="tr-main"> <div class="tr-type"><span class="tr-type-text">Enzymes</span></div> <div class="tr-img"> <svg viewBox="0 0 250 160" width="250" height="160" role="img"><title>InhA Inhibitor, IC50 = 26 nM</title><path d="M153.2 63.86a.64.64 0 01-.64-.64L152.45 51a.66.66 0 01.65-.66.65.65 0 01.65.64l.11 12.21a.66.66 0 01-.65.65zm-3.71-.17a.65.65 0 00.64-.65L150 50.83a.65.65 0 00-.65-.64.66.66 0 00-.65.64l.13 12.17a.64.64 0 00.64.64zm-90.77 9.9a.64.64 0 00.64-.66l-.1-12.21a.65.65 0 00-.65-.64.66.66 0 00-.64.66l.11 12.2a.66.66 0 00.65.65zM55 73.42a.66.66 0 00.64-.65l-.11-12.21a.65.65 0 00-.65-.64.66.66 0 00-.65.64l.11 12.21a.65.65 0 00.65.65zm3.72 48.46a.63.63 0 00.64-.65l-.1-12.2a.65.65 0 00-.65-.65.66.66 0 00-.61.62l.11 12.21a.66.66 0 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0 000-.07v-3.58h5v3.58a.3.3 0 00.25.34H142a.3.3 0 00.32-.27.09.09 0 000-.07v-8.75a.3.3 0 00-.25-.34h-1.25a.3.3 0 00-.33.27.2.2 0 000 .07v3.54h-5v-3.54a.29.29 0 00-.25-.34H134a.29.29 0 00-.32.27v8.82a.31.31 0 00.25.34h.07zm0 11.21h1.17a.3.3 0 00.33-.26.15.15 0 000-.07v-6.27l5.07 6.4a.48.48 0 00.41.2h1.17a.29.29 0 00.33-.27v-8.82a.3.3 0 00-.26-.33H141a.29.29 0 00-.32.26.08.08 0 000 .07V46l-5.07-6.43a.48.48 0 00-.41-.2H134a.29.29 0 00-.32.26v8.83a.29.29 0 00.25.33h.07z" fill="#0868b1"/><path d="M43.12 88l.11 11.16a1.43 1.43 0 01-.69 1.25l-15.67 9.66a1.44 1.44 0 01-.78.2 1.48 1.48 0 01-.71-.19l-8.25-4.55a1.45 1.45 0 111.29-2.6l.11.06 7.56 4.16 14.23-8.75-.11-10.34a1.47 1.47 0 011.44-1.47A1.46 1.46 0 0143.12 88zM25.78 73.74l6.9 3.78a1.45 1.45 0 101.55-2.46l-.14-.06-7.65-4.21a1.46 1.46 0 00-1.43.06L9.33 80.48a1.47 1.47 0 00-.69 1.25l.06 7.64a1.45 1.45 0 001.43 1.46 1.46 1.46 0 001.44-1.46l-.05-6.83zm35.89 30.13l-6.74 3.9a1.46 1.46 0 001.46 2.52l6.73-3.9a1.45 1.45 0 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011.26.68l9.81 15.57a1.43 1.43 0 01.06 1.44zm-2.95-.63l-8.93-14.17-16.73.34-7.78 14.45 8.93 14.16 16.73-.33z" fill="#2aa1db"/></svg> </div> <div class="trecord-main-content"> <div class="tr-target tr-text"> <strong class="tr-title">Target:</strong> InhA Inhibitor, IC<sub>50</sub> = 26 nM </div> <div class="tr-ta tr-text"> <strong class="tr-title">Therapy Area:</strong> Tuberculosis </div> </div> </div> <div class="tr-overlay"></div> </a> </div> </div> </div> </div> <div class="wp-block-buttons space-top is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-1 wp-block-buttons-is-layout-flex"> <div class="wp-block-button"><a class="wp-block-button__link wp-element-button" href="https://www.x-chemrx.com/del-track-record/">See Our Full Track Record of Success</a></div> </div> </div></div>  <div id="branded-bg-block_ca5ea4d688144aec80ee4413be5a0dc8" class="block-branded-bg wp-block-group no-top alignfull pattern-black has-background-image"> <div class="branded-bg-texture" style="background: url(https://www.x-chemrx.com/wp-content/uploads/2022/03/artemis-bg.png) center center / cover no-repeat;"> </div> <div class="branded-bg-inside"> <div class="branded-bg-content blocks-content"> <div class="kb-row-layout-wrap kb-row-layout-id7_e36ac7-06 alignnone wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column7_61585f-23 inner-column-1"><div class="kt-inside-inner-col"> <figure class="wp-block-image size-large is-resized"><img width="300" height="80" decoding="async" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20300%2080'%3E%3C/svg%3E" alt="ArtemisAI Accelerate Discovery" class="wp-image-21637" style="width:300px" data-lazy-src="https://www.x-chemrx.com/wp-content/uploads/2022/03/artemisAI-logo.svg"/><noscript><img width="300" height="80" decoding="async" src="https://www.x-chemrx.com/wp-content/uploads/2022/03/artemisAI-logo.svg" alt="ArtemisAI Accelerate Discovery" class="wp-image-21637" style="width:300px"/></noscript></figure> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading" style="font-size:1.5rem">Generate More Hits Faster</h2> <p>X-Chem’s proprietary ArtemisAI uses a suite of machine learning models paired with extensive DEL data to revolutionize the discovery of new medicines and realize the full potential of rich datasets.</p> <div class="wp-block-buttons black is-layout-flex wp-block-buttons-is-layout-flex"> <div class="wp-block-button"><a class="wp-block-button__link wp-element-button" href="https://www.x-chemrx.com/artemisai/">More About ArtemisAI</a></div> </div> </div></div> <div class="wp-block-kadence-column kadence-column7_d2beee-78 inner-column-2"><div class="kt-inside-inner-col"></div></div> </div></div> </div> </div> </div> <h2 class="wp-block-heading has-text-align-center no-bottom">What Our Clients Are Saying</h2> <div class="wp-block-group alignfull"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"><div id="slider-block_4fd978d5196d33e894c1ca96e04b890b" class="block-slider block-testimonial-slider alignwide"> <div class="sc-carousel-contain"> <div class="sc-carousel" data-slick='{"arrows": false, "dots": true}'> <div class="sc-slide"> <div class="sc-slide-inside"> <div class="sc-slide-content"> <figure> <blockquote><p>“Our multi-year collaboration with X-Chem has been fruitful and has resulted in projects that have successfully progressed to include many high potential products.” </p> </blockquote> <figcaption><span class="quote-author">Jacqueline Heard, Ph.D., MBA</span> <strong>CEO and Founder, Enko</strong> </figcaption> </figure> </div> </div> </div> <div class="sc-slide"> <div class="sc-slide-inside"> <div class="sc-slide-content"> <figure> <blockquote><p>“We are excited to expand our collaboration with X-Chem, focusing on the synthesis and delivery of custom libraries as well as the transfer of the DEX™ platform in-house, an important pillar of our small molecule discovery strategy.”</p> </blockquote> <figcaption><span class="quote-author">Sir Mene Pangalos</span> <strong>Executive Vice President, Early Discovery Research, AstraZeneca</strong> </figcaption> </figure> </div> </div> </div> <div class="sc-slide"> <div class="sc-slide-inside"> <div class="sc-slide-content"> <figure> <blockquote><p>“X-Chem’s approach to DEL libraries and screening complements Genentech’s small molecule drug discovery efforts and has the potential to help overcome long-standing challenges in drugging difficult oncology targets. We look forward to working with X-Chem to discover molecules that we hope could positively impact the lives of people with cancer.”</p> </blockquote> <figcaption><span class="quote-author">James Sabry, M.D., Ph.D.</span> <strong>Global Head of Pharma Partnering, Roche</strong> </figcaption> </figure> </div> </div> </div> <div class="sc-slide"> <div class="sc-slide-inside"> <div class="sc-slide-content"> <figure> <blockquote><p>“With the cutting-edge technology offered by X-Chem and our knowledge of dermatology, we will be able to broaden our pipeline and provide further medical solutions for physicians and patients, specially designed for dermatological diseases with unmet needs.”</p> </blockquote> <figcaption><span class="quote-author">Bhushan Hardas</span> <strong>Chief Scientific Officer, Almirall</strong> </figcaption> </figure> </div> </div> </div> <div class="sc-slide"> <div class="sc-slide-inside"> <div class="sc-slide-content"> <figure> <blockquote><p>“We anticipate that our drug discovery research will be further enhanced through X-Chem’s breakthrough technology, leading to the creation of breakthrough pharmaceuticals.”</p> </blockquote> <figcaption><span class="quote-author">Toshiki Sudo</span> <strong>Executive Director of Research and Intellectual Property, Otsuka</strong> </figcaption> </figure> </div> </div> </div> <div class="sc-slide"> <div class="sc-slide-inside"> <div class="sc-slide-content"> <figure> <blockquote><p>“As we tackle new targets, we have been very impressed with X-Chem’s technology platform and what it has delivered in the first 18 months of our partnership. Based on that success, we are eager to extend our work with X-Chem to additional targets for serious diseases.”</p> </blockquote> <figcaption><span class="quote-author">Mark Bunnage</span> <strong>Senior Vice President and Boston Research Site Head, Vertex</strong> </figcaption> </figure> </div> </div> </div> </div> </div> </div> </div></div> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"><div id="sc-video-block_83ef0b62537ab10e4a29e353e70e8a79" class="block-sc-video"> <a href="https://www.youtube.com/watch?v=9CI_gRnd2Ns" class="yt-launch" data-vid="sc-videobox-block_83ef0b62537ab10e4a29e353e70e8a79" aria-label="Play Video"> <img fetchpriority="high" decoding="async" width="1024" height="576" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201024%20576'%3E%3C/svg%3E" class="attachment-large size-large" alt="XD3 Dynamic Drug Discovery Video Thumbnail" 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