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</header> </div> <div id="content-contain"> <div id="primary" class="content-area"> <main id="main" class="site-main" role="main"> <article id="post-21372" class="post-21372 page type-page status-publish hentry"> <div class="entry-content"> <div class="blocks-content"> <div class="kb-row-layout-wrap kb-row-layout-id21372_5d9b6b-bf alignwide wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-2-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column21372_b3e848-c6 inner-column-1"><div class="kt-inside-inner-col"> <h2 class="wp-block-heading has-text-align-right" id="available-compounds-beyond-dna-encoded-libraries"><strong><strong>Screen <mark class="kt-highlight">Hundreds of Billions of Compounds</mark> Against Your Drug Discovery Target</strong></strong></h2> <div id="sc-video-block_3e5700a67f86ddae63110586f4ac8b0b" class="block-sc-video alignright"> <a href="https://youtu.be/u6jHLkoDEtQ" class="yt-launch" data-vid="sc-videobox-block_3e5700a67f86ddae63110586f4ac8b0b" aria-label="Play Video"> <img fetchpriority="high" decoding="async" width="1024" height="576" src="https://www.x-chemrx.com/wp-content/uploads/2023/11/del-explained-1024x576.jpeg" class="attachment-large size-large" alt="del explained x-chem" srcset="https://www.x-chemrx.com/wp-content/uploads/2023/11/del-explained-1024x576.jpeg 1024w, https://www.x-chemrx.com/wp-content/uploads/2023/11/del-explained-300x169.jpeg 300w, https://www.x-chemrx.com/wp-content/uploads/2023/11/del-explained-768x432.jpeg 768w, https://www.x-chemrx.com/wp-content/uploads/2023/11/del-explained.jpeg 1280w" sizes="(max-width: 1024px) 100vw, 1024px" /> <span class="yt-play-icon"><i class="icon-play"></i></span> <span style="display:none;">Play Video</span> </a> </div> <div id="sc-videobox-block_3e5700a67f86ddae63110586f4ac8b0b-contain" class="lightbox video-lightbox yt-player-contain"> <div class="lightbox-contain" > <button class="plain yt-close"></button> <div id="sc-videobox-block_3e5700a67f86ddae63110586f4ac8b0b" class="yt-player"></div> </div> </div> </div></div> <div class="wp-block-kadence-column kadence-column21372_6cac37-33 inner-column-2"><div class="kt-inside-inner-col"> <p>X-Chem’s DNA-encoded library (DEL) technology is deployed for and by clients around the world as an important method of small molecule discovery. Biotech and pharma companies recognize the exponential advantages of screening billions of compounds with astonishing speed and efficiency.</p> <p>Our libraries are maximally diverse and designed to generate hit compounds that jump-start medicinal chemistry programs. <a href="https://www.x-chemrx.com/delability/">DELability</a>, <a href="https://www.x-chemrx.com/delflex/">DELflex</a>, <a href="https://www.x-chemrx.com/delcore/">DELcore</a> and <a href="https://www.x-chemrx.com/delvalent/">DELvalent</a> offer target-based screening solutions and with our <a href="https://www.x-chemrx.com/delenable/">DELenable</a> option, we even deliver support to help clients build internal DEL capabilities using our extensive experience.</p> </div></div> </div></div>  <div id="separator-block_6c88cd0dc6618bbc08ee2afbd943ecb2" class="block-separator alignwide"> <svg id="Layer_1" data-name="Layer 1" class="x-separator" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1897.14 16.62" preserveAspectRatio="xMidYMid slice"><defs><style>.cls-1{fill:#9aca3c;}.cls-2{fill:#2aa1db;}.cls-3{fill:#ef4379;}.cls-4{fill:#e6e6e6;stroke:#e6e6e6;stroke-miterlimit:10;}</style></defs><path class="cls-1" d="M932,16.34h-8.92a1.29,1.29,0,0,1-1.24-.9L919.07,7a1.31,1.31,0,0,1,.48-1.46L926.76.26a1.29,1.29,0,0,1,1.54,0l7.21,5.2A1.31,1.31,0,0,1,936,6.92l-2.76,8.54A1.29,1.29,0,0,1,932,16.34Zm-8-2.62h7l2.16-6.66-5.67-4.13-5.67,4.13Z" transform="translate(0 0)"/><path class="cls-2" d="M953.16,15.23h-11.5a1.31,1.31,0,0,1-1.27-1.31V2.46a1.31,1.31,0,0,1,1.31-1.31h11.5a1.31,1.31,0,0,1,1.27,1.31V13.92A1.31,1.31,0,0,1,953.16,15.23ZM943,12.61h8.88V3.74H943Z" transform="translate(0 0)"/><path class="cls-3" d="M971,16.62h-7.44a1.29,1.29,0,0,1-1.13-.66l-3.72-6.44a1.33,1.33,0,0,1,0-1.31l3.72-6.44a1.3,1.3,0,0,1,1.13-.65H971a1.33,1.33,0,0,1,1.14.65l3.71,6.44a1.28,1.28,0,0,1,0,1.31L972.15,16A1.32,1.32,0,0,1,971,16.62ZM964.33,14h5.93l3-5.13-3-5.13h-5.93l-3,5.13Z" transform="translate(0 0)"/><rect class="cls-4" x="0.5" y="8.38" width="863" height="2"/><rect class="cls-4" x="1033.64" y="8.37" width="863" height="2"/></svg> </div> <div class="wp-block-image"> <figure class="aligncenter size-large is-resized"><img width="80" height="70" decoding="async" src="https://www.x-chemrx.com/wp-content/uploads/2021/03/library-tech-services.svg" alt="DEL Technologies" class="wp-image-2368" style="width:140px"/></figure></div> <p>X-Chem’s versatile DEL screening is proven in projects spanning numerous target classes. Our robust process has been highly successful against targets considered difficult or even intractable, such as:</p> <div class="wp-block-columns no-top is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <ul class="wp-block-list"> <li>Protein-protein interactions</li> <li>Ubiquitin ligases</li> <li>Epigenetic targets</li> </ul> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <ul class="wp-block-list"> <li>G protein-coupled receptors</li> <li>Bacterial enzymes</li> </ul> </div> </div> <p>Our platform, libraries and screening strategies are designed to generate compound classes that can address any target and modality:</p> <div class="wp-block-columns no-top is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <ul class="wp-block-list"> <li>Lead-like compounds</li> <li>Drug-like compounds</li> <li>Macrocycles</li> <li>Peptides</li> </ul> </div> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow"> <ul class="wp-block-list"> <li>Covalent inhibitors</li> <li>Protein degraders</li> <li>Allosteric inhibitors</li> </ul> </div> </div>  <div id="separator-block_6c88cd0dc6618bbc08ee2afbd943ecb2" class="block-separator alignwide"> <svg id="Layer_1" data-name="Layer 1" class="x-separator" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 1897.14 16.62" preserveAspectRatio="xMidYMid slice"><defs><style>.cls-1{fill:#9aca3c;}.cls-2{fill:#2aa1db;}.cls-3{fill:#ef4379;}.cls-4{fill:#e6e6e6;stroke:#e6e6e6;stroke-miterlimit:10;}</style></defs><path class="cls-1" d="M932,16.34h-8.92a1.29,1.29,0,0,1-1.24-.9L919.07,7a1.31,1.31,0,0,1,.48-1.46L926.76.26a1.29,1.29,0,0,1,1.54,0l7.21,5.2A1.31,1.31,0,0,1,936,6.92l-2.76,8.54A1.29,1.29,0,0,1,932,16.34Zm-8-2.62h7l2.16-6.66-5.67-4.13-5.67,4.13Z" transform="translate(0 0)"/><path class="cls-2" d="M953.16,15.23h-11.5a1.31,1.31,0,0,1-1.27-1.31V2.46a1.31,1.31,0,0,1,1.31-1.31h11.5a1.31,1.31,0,0,1,1.27,1.31V13.92A1.31,1.31,0,0,1,953.16,15.23ZM943,12.61h8.88V3.74H943Z" transform="translate(0 0)"/><path class="cls-3" d="M971,16.62h-7.44a1.29,1.29,0,0,1-1.13-.66l-3.72-6.44a1.33,1.33,0,0,1,0-1.31l3.72-6.44a1.3,1.3,0,0,1,1.13-.65H971a1.33,1.33,0,0,1,1.14.65l3.71,6.44a1.28,1.28,0,0,1,0,1.31L972.15,16A1.32,1.32,0,0,1,971,16.62ZM964.33,14h5.93l3-5.13-3-5.13h-5.93l-3,5.13Z" transform="translate(0 0)"/><rect class="cls-4" x="0.5" y="8.38" width="863" height="2"/><rect class="cls-4" x="1033.64" y="8.37" width="863" height="2"/></svg> </div> <h4 class="kt-adv-heading21372_6797df-39 wp-block-kadence-advancedheading" data-kb-block="kb-adv-heading21372_6797df-39"><strong>HOW DEL-DRIVEN DRUG DISCOVERY WORKS</strong>:</h4> <h2 class="kt-adv-heading21372_0c260a-30 wp-block-kadence-advancedheading" data-kb-block="kb-adv-heading21372_0c260a-30">Combinatorial Chemistry, DNA Tagging and High Affinity-Based Screening</h2> <div class="kb-row-layout-wrap kb-row-layout-id21372_61a97c-25 alignwide wp-block-kadence-rowlayout"><div class="kt-row-column-wrap kt-has-1-columns kt-row-layout-equal kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top"> <div class="wp-block-kadence-column kadence-column21372_cd117f-46 inner-column-1"><div class="kt-inside-inner-col"><div class="wp-block-image"> <figure class="aligncenter size-large"><img decoding="async" width="1024" height="320" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201024%20320'%3E%3C/svg%3E" alt="X-Chem_Steps1-6_Graphic (1)" class="wp-image-24926" data-lazy-srcset="https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-1024x320.png 1024w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-300x94.png 300w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-768x240.png 768w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-1536x479.png 1536w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-2048x639.png 2048w" data-lazy-sizes="(max-width: 1024px) 100vw, 1024px" data-lazy-src="https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-1024x320.png" /><noscript><img decoding="async" width="1024" height="320" src="https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-1024x320.png" alt="X-Chem_Steps1-6_Graphic (1)" class="wp-image-24926" srcset="https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-1024x320.png 1024w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-300x94.png 300w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-768x240.png 768w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-1536x479.png 1536w, https://www.x-chemrx.com/wp-content/uploads/2024/06/X-Chem_Steps1-6_Graphic-1-2048x639.png 2048w" sizes="(max-width: 1024px) 100vw, 1024px" /></noscript></figure></div></div></div> </div></div>  <div id="hexagon-block_45a5788200b3e8a8e550fbc4b9c10f8c" class="block-hexagon aligncenter"> <table> <tr><td><span class="x-hexagon">1</span></td> <td> <p>The X-Chem drug discovery engine is based on a compound library generated by iterative combinatorial synthesis. In the DEL process, each molecule in the library is tethered to a distinct DNA tag or “bar code” that records its synthetic history.</p> </td> </tr> </table> </div>  <div id="hexagon-block_39a7c69b3b1a2ffac740837e29b86be2" class="block-hexagon aligncenter"> <table> <tr><td><span class="x-hexagon">2</span></td> <td> <p>Billions of small molecules are screened as a mixture in a single vessel against a target of interest. Conducting multiple screening experiments in parallel provides informative and actionable output.</p> </td> </tr> </table> </div>  <div id="hexagon-block_bec9baad8496ac597257018f46f4cabb" class="block-hexagon aligncenter"> <table> <tr><td><span class="x-hexagon">3</span></td> <td> <p>DNA amplification and sequencing methods are then used to identify the molecules that have an affinity for your target.</p> </td> </tr> </table> </div>  <div id="hexagon-block_b7a7d406c7d87d62aac5b55679a56d12" class="block-hexagon aligncenter"> <table> <tr><td><span class="x-hexagon">4</span></td> <td> <p>Proprietary bioinformatics tools allow the translation of DNA sequence data into chemical structure, and the analysis of the enrichment and structural characteristics of the resulting ligands.</p> </td> </tr> </table> </div>  <div id="hexagon-block_f8f45a9654c2c9d4667801900e591239" class="block-hexagon aligncenter"> <table> <tr><td><span class="x-hexagon">5</span></td> <td> <p>Based on the synthetic history encoded in the DNA sequence information, promising molecules are then synthesized without the DNA tag attached.</p> </td> </tr> </table> </div>  <div id="hexagon-block_623eaaa7d78491a685699e380975216a" class="block-hexagon aligncenter"> <table> <tr><td><span class="x-hexagon">6</span></td> <td> <p>These de-tagged hits are then retested in biological assays to confirm that they exhibit the desired activity. The structure-activity relationships observed in the screening help accelerate hit-to-lead medicinal chemistry.</p> </td> </tr> </table> </div> <p class="has-text-align-center">Whether you are a DEL practitioner or an investigator looking for equity against a novel target, we will help you leverage our platform, technology and expertise in the best way possible.</p> </div> </div> </article> </main> </div> </div>  </div> <div data-wpr-lazyrender="1" id="pre-foot"> <div class="pre-foot-content"> <h3 id="foot-cta">Small Molecules Hold Exponential Possibilities <strong>Find Your Next Drug Candidate With X-Chem</strong></h3> <a id="foot-cta-link" href="https://www.x-chemrx.com/contact-us/" target="" class="btn reverse">Talk To Us</a> </div> </div> <footer data-wpr-lazyrender="1" id="colophon" class="site-footer"> <div class="foot-content row"> <div id="site-info" class="site-info foot-part"> <div class="site-info-row"> <p id="copyright-statement">© 2024 X-Chem. 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