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class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/2411.02966">arXiv:2411.02966</a> <span> [<a href="https://arxiv.org/pdf/2411.02966">pdf</a>, <a href="https://arxiv.org/format/2411.02966">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Accelerator Physics">physics.acc-ph</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.5281/zenodo.13970100">10.5281/zenodo.13970100 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> MuCol Milestone Report No. 5: Preliminary Parameters </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/?searchtype=author&query=Accettura%2C+C">Carlotta Accettura</a>, <a href="/search/?searchtype=author&query=Adrian%2C+S">Simon Adrian</a>, <a href="/search/?searchtype=author&query=Agarwal%2C+R">Rohit Agarwal</a>, <a href="/search/?searchtype=author&query=Ahdida%2C+C">Claudia Ahdida</a>, <a href="/search/?searchtype=author&query=Aim%C3%A9%2C+C">Chiara Aim茅</a>, <a href="/search/?searchtype=author&query=Aksoy%2C+A">Avni Aksoy</a>, <a href="/search/?searchtype=author&query=Alberghi%2C+G+L">Gian Luigi Alberghi</a>, <a href="/search/?searchtype=author&query=Alden%2C+S">Siobhan Alden</a>, <a href="/search/?searchtype=author&query=Alfonso%2C+L">Luca Alfonso</a>, <a href="/search/?searchtype=author&query=Amapane%2C+N">Nicola Amapane</a>, <a href="/search/?searchtype=author&query=Amorim%2C+D">David Amorim</a>, <a href="/search/?searchtype=author&query=Andreetto%2C+P">Paolo Andreetto</a>, <a href="/search/?searchtype=author&query=Anulli%2C+F">Fabio Anulli</a>, <a href="/search/?searchtype=author&query=Appleby%2C+R">Rob Appleby</a>, <a href="/search/?searchtype=author&query=Apresyan%2C+A">Artur Apresyan</a>, <a href="/search/?searchtype=author&query=Asadi%2C+P">Pouya Asadi</a>, <a href="/search/?searchtype=author&query=Mahmoud%2C+M+A">Mohammed Attia Mahmoud</a>, <a href="/search/?searchtype=author&query=Auchmann%2C+B">Bernhard Auchmann</a>, <a href="/search/?searchtype=author&query=Back%2C+J">John Back</a>, <a href="/search/?searchtype=author&query=Badea%2C+A">Anthony Badea</a>, <a href="/search/?searchtype=author&query=Bae%2C+K+J">Kyu Jung Bae</a>, <a href="/search/?searchtype=author&query=Bahng%2C+E+J">E. J. Bahng</a>, <a href="/search/?searchtype=author&query=Balconi%2C+L">Lorenzo Balconi</a>, <a href="/search/?searchtype=author&query=Balli%2C+F">Fabrice Balli</a>, <a href="/search/?searchtype=author&query=Bandiera%2C+L">Laura Bandiera</a> , et al. (369 additional authors not shown) </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="2411.02966v1-abstract-short" style="display: inline;"> This document is comprised of a collection of updated preliminary parameters for the key parts of the muon collider. The updated preliminary parameters follow on from the October 2023 Tentative Parameters Report. Particular attention has been given to regions of the facility that are believed to hold greater technical uncertainty in their design and that have a strong impact on the cost and power… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2411.02966v1-abstract-full').style.display = 'inline'; document.getElementById('2411.02966v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="2411.02966v1-abstract-full" style="display: none;"> This document is comprised of a collection of updated preliminary parameters for the key parts of the muon collider. The updated preliminary parameters follow on from the October 2023 Tentative Parameters Report. Particular attention has been given to regions of the facility that are believed to hold greater technical uncertainty in their design and that have a strong impact on the cost and power consumption of the facility. The data is collected from a collaborative spreadsheet and transferred to overleaf. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2411.02966v1-abstract-full').style.display = 'none'; document.getElementById('2411.02966v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 5 November, 2024; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> November 2024. </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/2002.05697">arXiv:2002.05697</a> <span> [<a href="https://arxiv.org/pdf/2002.05697">pdf</a>, <a href="https://arxiv.org/format/2002.05697">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Statistical Finance">q-fin.ST</span> </div> </div> <p class="title is-5 mathjax"> Analysis of intra-day fluctuations in the Mexican financial market index </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/?searchtype=author&query=Alfonso%2C+L">L茅ster Alfonso</a>, <a href="/search/?searchtype=author&query=Garcia-Ramirez%2C+D+E">Danahe E. Garcia-Ramirez</a>, <a href="/search/?searchtype=author&query=Mansilla%2C+R">Ricardo Mansilla</a>, <a href="/search/?searchtype=author&query=Terrero-Escalante%2C+C+A">C茅sar A. Terrero-Escalante</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="2002.05697v1-abstract-short" style="display: inline;"> In this paper, a statistical analysis of high frequency fluctuations of the IPC, the Mexican Stock Market Index, is presented. A sample of tick-to-tick data covering the period from January 1999 to December 2002 was analyzed, as well as several other sets obtained using temporal aggregation. Our results indicates that the highest frequency is not useful to understand the Mexican market because alm… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2002.05697v1-abstract-full').style.display = 'inline'; document.getElementById('2002.05697v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="2002.05697v1-abstract-full" style="display: none;"> In this paper, a statistical analysis of high frequency fluctuations of the IPC, the Mexican Stock Market Index, is presented. A sample of tick-to-tick data covering the period from January 1999 to December 2002 was analyzed, as well as several other sets obtained using temporal aggregation. Our results indicates that the highest frequency is not useful to understand the Mexican market because almost two thirds of the information corresponds to inactivity. For the frequency where fluctuations start to be relevant, the IPC data does not follows any alpha-stable distribution, including the Gaussian, perhaps because of the presence of autocorrelations. For a long range of lower-frequencies, but still in the intra-day regime, fluctuations can be described as a truncated L茅vy flight, while for frequencies above two-days, a Gaussian distribution yields the best fit. Thought these results are consistent with other previously reported for several markets, there are significant differences in the details of the corresponding descriptions. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2002.05697v1-abstract-full').style.display = 'none'; document.getElementById('2002.05697v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 13 February, 2020; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> February 2020. </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1604.05082">arXiv:1604.05082</a> <span> [<a href="https://arxiv.org/pdf/1604.05082">pdf</a>, <a href="https://arxiv.org/format/1604.05082">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Tissues and Organs">q-bio.TO</span> </div> </div> <p class="title is-5 mathjax"> Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/?searchtype=author&query=Alfonso%2C+J+C+L">J. C. L. Alfonso</a>, <a href="/search/?searchtype=author&query=Kohn-Luque%2C+A">A. Kohn-Luque</a>, <a href="/search/?searchtype=author&query=Stylianopoulos%2C+T">T. Stylianopoulos</a>, <a href="/search/?searchtype=author&query=Feuerhake%2C+F">F. Feuerhake</a>, <a href="/search/?searchtype=author&query=Deutsch%2C+A">A. Deutsch</a>, <a href="/search/?searchtype=author&query=Hatzikirou%2C+H">H. Hatzikirou</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1604.05082v1-abstract-short" style="display: inline;"> There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve functional tumour-associated blood vessel deterioration and normalisation. The former aims at tumour infarction and nutrient deprivation medi- ated by vascular targeting agents that induce occlusion/collapse of tumour blood vessels. In… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1604.05082v1-abstract-full').style.display = 'inline'; document.getElementById('1604.05082v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1604.05082v1-abstract-full" style="display: none;"> There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve functional tumour-associated blood vessel deterioration and normalisation. The former aims at tumour infarction and nutrient deprivation medi- ated by vascular targeting agents that induce occlusion/collapse of tumour blood vessels. In contrast, the therapeutic intention of normalising the abnormal structure and function of tumour vascular net- works, e.g. via alleviating stress-induced vaso-occlusion, is to improve chemo-, immuno- and radiation therapy efficacy. Although both strategies have shown therapeutic potential, it remains unclear why they often fail to control glioma invasion into the surrounding healthy brain tissue. To shed light on this issue, we propose a mathematical model of glioma invasion focusing on the interplay between the mi- gration/proliferation dichotomy (Go-or-Grow) of glioma cells and modulations of the functional tumour vasculature. Vaso-modulatory interventions are modelled by varying the degree of vaso-occlusion. We discovered the existence of a critical cell proliferation/diffusion ratio that separates glioma invasion re- sponses to vaso-modulatory interventions into two distinct regimes. While for tumours, belonging to one regime, vascular modulations reduce the tumour front speed and increase the infiltration width, for those in the other regime the invasion speed increases and infiltration width decreases. We show how these in silico findings can be used to guide individualised approaches of vaso-modulatory treatment strategies and thereby improve success rates. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1604.05082v1-abstract-full').style.display = 'none'; document.getElementById('1604.05082v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 18 April, 2016; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> April 2016. </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1507.06614">arXiv:1507.06614</a> <span> [<a href="https://arxiv.org/pdf/1507.06614">pdf</a>, <a href="https://arxiv.org/format/1507.06614">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Tissues and Organs">q-bio.TO</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Cell Behavior">q-bio.CB</span> </div> </div> <p class="title is-5 mathjax"> In silico tumor control induced via alternating immunostimulating and immunosuppressive phases </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/?searchtype=author&query=Reppas%2C+A+I">A. I. Reppas</a>, <a href="/search/?searchtype=author&query=Alfonso%2C+J+C+L">J. C. L. Alfonso</a>, <a href="/search/?searchtype=author&query=Hatzikirou%2C+H">H. Hatzikirou</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1507.06614v1-abstract-short" style="display: inline;"> Despite recent advances in the field of Oncoimmunology, the success potential of immunomodulatory therapies against cancer remains to be elucidated. One of the reasons is the lack of understanding on the complex interplay between tumor growth dynamics and the associated immune system responses. Towards this goal, we consider a mathematical model of vascularized tumor growth and the corresponding e… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1507.06614v1-abstract-full').style.display = 'inline'; document.getElementById('1507.06614v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1507.06614v1-abstract-full" style="display: none;"> Despite recent advances in the field of Oncoimmunology, the success potential of immunomodulatory therapies against cancer remains to be elucidated. One of the reasons is the lack of understanding on the complex interplay between tumor growth dynamics and the associated immune system responses. Towards this goal, we consider a mathematical model of vascularized tumor growth and the corresponding effector cell recruitment dynamics. Bifurcation analysis allows for the exploration of model's dynamic behavior and the determination of these parameter regimes that result in immune-mediated tumor control. Here, we focus on a particular tumor evasion regime that involves tumor and effector cell concentration oscillations of slowly increasing and decreasing amplitude, respectively. Considering a temporal multiscale analysis, we derive an analytically tractable mapping of model solutions onto a weakly negatively damped harmonic oscillator. Based on our analysis, we propose a theory-driven intervention strategy involving immunostimulating and immunosuppressive phases to induce long-term tumor control. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1507.06614v1-abstract-full').style.display = 'none'; document.getElementById('1507.06614v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 22 July, 2015; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> July 2015. </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1505.05670">arXiv:1505.05670</a> <span> [<a href="https://arxiv.org/pdf/1505.05670">pdf</a>, <a href="https://arxiv.org/format/1505.05670">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Tissues and Organs">q-bio.TO</span> </div> </div> <p class="title is-5 mathjax"> Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/?searchtype=author&query=Hatzikirou%2C+H">H. Hatzikirou</a>, <a href="/search/?searchtype=author&query=Alfonso%2C+J+C+L">J. C. L. Alfonso</a>, <a href="/search/?searchtype=author&query=Muhle%2C+S">S. Muhle</a>, <a href="/search/?searchtype=author&query=Stern%2C+C">C. Stern</a>, <a href="/search/?searchtype=author&query=Weiss%2C+S">S. Weiss</a>, <a href="/search/?searchtype=author&query=Meyer-Hermann%2C+M">M. Meyer-Hermann</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1505.05670v3-abstract-short" style="display: inline;"> Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of vascularized tumor growth, where the main novelty is the modeling of the interplay between functional tumor vasculature and effector cell recruitment dynamics. Paramete… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1505.05670v3-abstract-full').style.display = 'inline'; document.getElementById('1505.05670v3-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1505.05670v3-abstract-full" style="display: none;"> Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of vascularized tumor growth, where the main novelty is the modeling of the interplay between functional tumor vasculature and effector cell recruitment dynamics. Parameters are calibrated on the basis of different in vivo immunocompromised Rag1-/- and wild-type (WT) BALB/c murine tumor growth experiments. The model analysis supports that tumor vasculature normalization can be a plausible and effective strategy to treat cancer when combined with appropriate immuno-stimulations. We find that improved levels of functional tumor vasculature, potentially mediated by normalization or stress alleviation strategies, can provide beneficial outcomes in terms of tumor burden reduction and growth control. Normalization of tumor blood vessels opens a therapeutic window of opportunity to augment the antitumor immune responses, as well as to reduce the intratumoral immunosuppression and induced-hypoxia due to vascular abnormalities. The potential success of normalizing tumor-associated vasculature closely depends on the effector cell recruitment dynamics and tumor sizes. Furthermore, an arbitrary increase of initial effector cell concentration does not necessarily imply a better tumor control. We evidence the existence of an optimal concentration range of effector cells for tumor shrinkage. Based on these findings, we suggest a theory-driven therapeutic proposal that optimally combines immuno- and vaso-modulatory interventions. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1505.05670v3-abstract-full').style.display = 'none'; document.getElementById('1505.05670v3-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 6 October, 2015; <span class="has-text-black-bis has-text-weight-semibold">v1</span> submitted 21 May, 2015; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> May 2015. </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1111.2038">arXiv:1111.2038</a> <span> [<a href="https://arxiv.org/pdf/1111.2038">pdf</a>, <a href="https://arxiv.org/ps/1111.2038">ps</a>, <a href="https://arxiv.org/format/1111.2038">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Statistical Finance">q-fin.ST</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Data Analysis, Statistics and Probability">physics.data-an</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1016/j.physa.2012.01.023">10.1016/j.physa.2012.01.023 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> On the scaling of the distribution of daily price fluctuations in Mexican financial market index </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/?searchtype=author&query=Alfonso%2C+L">Lester Alfonso</a>, <a href="/search/?searchtype=author&query=Mansilla%2C+R">Ricardo Mansilla</a>, <a href="/search/?searchtype=author&query=Terrero-Escalante%2C+C+A">Cesar A. Terrero-Escalante</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1111.2038v1-abstract-short" style="display: inline;"> In this paper, a statistical analysis of log-return fluctuations of the IPC, the Mexican Stock Market Index is presented. A sample of daily data covering the period from $04/09/2000-04/09/2010$ was analyzed, and fitted to different distributions. Tests of the goodness of fit were performed in order to quantitatively asses the quality of the estimation. Special attention was paid to the impact of t… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1111.2038v1-abstract-full').style.display = 'inline'; document.getElementById('1111.2038v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1111.2038v1-abstract-full" style="display: none;"> In this paper, a statistical analysis of log-return fluctuations of the IPC, the Mexican Stock Market Index is presented. A sample of daily data covering the period from $04/09/2000-04/09/2010$ was analyzed, and fitted to different distributions. Tests of the goodness of fit were performed in order to quantitatively asses the quality of the estimation. Special attention was paid to the impact of the size of the sample on the estimated decay of the distributions tail. In this study a forceful rejection of normality was obtained. On the other hand, the null hypothesis that the log-fluctuations are fitted to a $伪$-stable L茅vy distribution cannot be rejected at 5% significance level. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1111.2038v1-abstract-full').style.display = 'none'; document.getElementById('1111.2038v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 8 November, 2011; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> November 2011. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">13 pages, 4 figures, 4 tables</span> </p> </li> </ol> <div class="is-hidden-tablet">  <span class="help" style="display: inline-block;"><a href="https://github.com/arXiv/arxiv-search/releases">Search v0.5.6 released 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