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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-10-23T16:33:44.716">October 23, 2024</time></div><h1 class="text-[26px] font-medium leading-8">FDA Approves Abrysvo RSV Vaccine for Adults at Increased Risk </h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/pearl-steinzor">Pearl Steinzor</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="FDA Approves Abrysvo RSV Vaccine for Adults at Increased Risk " aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" class="react-share__ShareButton" 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2px; } audio { height: 40px; } .rhap_container { width: 300px !important; border-radius: 100px !important; height: 40px !important; box-shadow: 0px 0px 2px 2px rgba(0,0,0,0.1); } .rhap_progress-section { width: 150px; margin-left: 35px; } .rhap_controls-section { position: relative; bottom: .75rem; } .rhap_time { font-size: 12px; color: rgb(0,55,103); } .rhap_progress-bar { color: rgb(0,55,103) !important; } .rhap_progress-filled { background-color: rgb(0,55,103) !important; } .rhap_progress-indicator { height: 15px; width: 5px; top: -5px; margin-left: 1px; background-color: rgb(0,55,103) !important; } .rhap_repeat-button { display: none; } .rhap_volume-bar, rhap_volume-button, .rhap_volume-indicator { background: rgb(0,55,103) !important; } .rhap_volume-bar { height: 2px; width: 35px; position: relative; left: 22px; bottom: 21px; } .rhap_volume-button { // width: 5px; // height: 5px; flex: 0 0 26px; position: relative; left: 22px; bottom: 21px; } .rhap_volume-button svg { height: 18px; width: 18px; } .rhap_volume-indicator { height: 8px; width: 8px; top: -2.75px } .rhap_button-clear { color: rgb(0,55,103) !important; } .rhap_play-pause-button { color: rgb(0,55,103) !important; font-size: 30px !important; width: 30px !important; height: 30px !important; position: relative; right: 90px; bottom: 22px; } .rhap_main-controls button { color: rgb(0,55,103) !important; } audio::-webkit-media-controls-play-button, video::-webkit-media-controls-play-button { -webkit-appearance: media-play-button; color: #b8dcf6; } audio::-webkit-media-controls-panel { background-color: white !important; color: #000; } audio::-webkit-media-controls-current-time-display, audio::-webkit-media-controls-time-remaining-display { font-size: 12px; } </style></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><div class="w-full flex flex-col px-4 py-4 border-t border-b border-solid border-gray-400 my-4 "><h3 class="text-primary text-xl font-semibold">Key Takeaways</h3><ul class="list-disc px-8"><li class="py-2 "> Abrysvo is now approved for adults aged 18-59 years at increased risk for RSV due to chronic conditions, expanding its previous indications. </li><li class="py-2 "> The FDA's decision is based on a phase 3 trial showing safety and efficacy in adults with chronic conditions. </li><li class="py-2 hidden"> CDC recommends RSV vaccination for adults over 60 and those at increased risk, using vaccines like Abrysvo. </li><li class="py-2 hidden"> Common adverse reactions include injection site pain, muscle pain, and nausea across different age groups.</li></ul><span class="text-xs font-bold text-primary underline cursor-pointer mt-2 ml-4">SHOW MORE</span></div><p class="py-2 mb-2 text-sm italic text-gray-600">Abrysvo is the first and only respiratory syncytial virus (RSV) vaccine indicated for adults younger than 50 years. </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><p class="pb-2">The FDA has approved Pfizer’s <a target="_blank" href="https://www.ajmc.com/compendium/rsv">respiratory syncytial virus</a> (RSV) vaccine, Abrysvo, for adults aged 18 to 59 years who are at increased risk for the disease.<sup class="text-inherit">1</sup></p><div class=""><div style="width:33%;float:left;max-width:525px;margin:0 1.5rem 1.5rem 0;clear:both;cursor:" class=" figure"><div class="flex-none relative text-center"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span style="box-sizing:border-box;display:block;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;max-width:100%"><img style="display:block;max-width:100%;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0" alt="" aria-hidden="true" src="data:image/svg+xml,%3csvg%20xmlns=%27http://www.w3.org/2000/svg%27%20version=%271.1%27%20width=%277680%27%20height=%274320%27/%3e"/></span><img alt="RSV vaccine | Peter Hansen - stock.adobe.com" title="RSV vaccine | Peter Hansen - stock.adobe.com" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="RSV vaccine | Peter Hansen - stock.adobe.com" title="RSV vaccine | Peter Hansen - stock.adobe.com" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fec5d7f3ca4327cf6946c47b72824c06b31815c29-7680x4320.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 1x" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fec5d7f3ca4327cf6946c47b72824c06b31815c29-7680x4320.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="intrinsic" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div id="image-caption" class="text-gray-500 italic"><div class="blockText_blockContent__TbCXh"><p class="pb-2"><div style="text-align:center">The FDA has approved Pfizer’s respiratory syncytial virus (RSV) vaccine, Abysvo, for adults aged 18 to 59 years who are at increased risk for the disease. | Image credit: Peter Hansen - stock.adobe.com</div></p></div></div><div class="top-[-100%] block w-[1px] transition-opacity duration-500 ease-in-out opacity-0 overflow-hidden"><img class="m-auto absolute inset-0 max-w-[0%] max-h-[0%] border-[3px] border-solid border-white shadow-[0px_0px_8px_rgba(0,0,0,0.3)] box-border transition ease-in-out duration-500" src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ec5d7f3ca4327cf6946c47b72824c06b31815c29-7680x4320.jpg?fit=crop&auto=format"/></div></div><style> #image-caption p{ font-size: 12px; max-width: 525px; margin: 0 auto; text-align: center; } </style></div><p class="pb-2">“RSV represents a significant threat to younger adults with certain chronic conditions,” Aamir Malik, chief US commercial officer and executive vice president, Pfizer, said in a <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.pfizer.com/news/press-release/press-release-detail/us-fda-approves-abrysvotm-pfizers-vaccine-prevention#:~:text=On%20March%2024%2C%202022%2C%20Pfizer,years%20of%20age%20and%20older">statement</a>. “After decades of vaccine research by the scientific community and Pfizer, we now have the opportunity to help alleviate the burden of RSV in this high-risk adult population. With this approval, we are proud that Abrysvo is now the only RSV vaccine indicated for adults aged 18 to 49 at increased risk for the disease, expanding on its existing indications for older adults and pregnant women.”</p><p class="pb-2"></p><p class="pb-2">On March 24, 2022, the FDA granted Breakthrough Therapy Designation for Abrysvo for the prevention of lower respiratory tract disease (LRTD) caused by RSV in individuals aged 60 years and older.<sup class="text-inherit">2</sup> Since then, Pfizer has worked to expand the vaccine’s reach in immunocompromised adults. In August, Pfizer announced top-line results of Abrysvo being well-tolerated and effective in generating strong neutralizing responses in adults aged 18 years and older.<sup class="text-inherit">3</sup></p><p class="pb-2"></p><p class="pb-2">On June 26, 2024, the CDC’s Advisory Committee on Immunization Practices (ACIP) updated its recommendations that all adults aged 75 and older and adults aged 60 to 74 years who are at increased risk for severe RSV should receive a single dose of the RSV vaccine (Arexvy [GSK], Abrysvo [Pfizer], or mResvia [Moderna]).<sup class="text-inherit">4</sup></p><p class="pb-2"></p><p class="pb-2">The FDA’s most recent decision on Abrysvo is based on inferred efficacy from the pivotal phase 3 clinical trial (NCT05842967), which investigated the safety, tolerability, and immunogenicity of the vaccine in adults at risk of RSV-associated disease due to certain chronic medical conditions.<sup class="text-inherit">1</sup></p><p class="pb-2"></p><p class="pb-2">Among all US adults aged 18 to 49 years, 9.5% have an underlying chronic condition, such as obesity, <a target="_blank" href="https://www.ajmc.com/compendium/diabetes">diabetes</a>, <a target="_blank" href="https://www.ajmc.com/compendium/copd">chronic obstructive pulmonary disease</a> (COPD), <a target="_blank" href="https://www.ajmc.com/compendium/heart-failure">heart failure</a>, <a target="_blank" href="https://www.ajmc.com/compendium/ckd">chronic kidney disease</a>, and <a target="_blank" href="https://www.ajmc.com/compendium/asthma">asthma</a>, putting them at increased risk of developing and being hospitalized for RSV-associated LRTD. This risk is exacerbated by 24.3% of all US adults aged 50 to 64.</p><p class="pb-2"></p><p class="pb-2">Abrysvo is indicated in the US for the prevention of LTRD caused by RSV in adults aged 60 years and older, the prevention of LTRD caused by RSV in adults aged 18 through 59 years who are at increased risk for LRTD caused by RSV, and pregnant individuals at 32 through 36 weeks gestational age for the prevention of LRTD and severe RSV caused by RSV in infants from birth through 6 months of age.</p><p class="pb-2"></p><p class="pb-2">The most reported adverse reactions in pregnant individuals were pain at the injection site (40.6%), headache (31%), muscle pain (26.5%), and nausea (20%). In individuals aged 60 years and older, fatigue (15.7%), headache (12.9%), pain at the injection site (10.7%), and muscle pain (10.2%) were the most reported adverse reactions. Among those aged 18 through 59 years, the most common adverse reactions were pain at the injection site (35.3%), muscle pain (24.4%), joint pain (12.4%), and nausea (11.8%).<sup class="text-inherit">5</sup></p><p class="pb-2"></p><p class="pb-2"></p><p class="pb-2"><strong>References</strong></p><p class="pb-2">1. US FDA approves Pfizer’s RSV vaccine Abrysvo for adults aged 18 to 59 at increased risk for disease. Pfizer Inc. News release. October 22, 2024. Accessed October 23, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.businesswire.com/news/home/20241018199265/en/U.S.-FDA-Approves-Pfizer%E2%80%99s-RSV-Vaccine-ABRYSVO%C2%AE-for-Adults-Aged-18-to-59-at-Increased-Risk-for-Disease">https://www.businesswire.com/news/home/20241018199265/en/U.S.-FDA-Approves-Pfizer%E2%80%99s-RSV-Vaccine-ABRYSVO%C2%AE-for-Adults-Aged-18-to-59-at-Increased-Risk-for-Disease</a>.</p><p class="pb-2">2. US FDA approves Abrysvo, Pfizer’s vaccine for the prevention of respiratory syncytial virus (RSV) in older adults. Pfizer Inc. News release. May 31, 2023. Accessed October 23, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://www.pfizer.com/news/press-release/press-release-detail/us-fda-approves-abrysvotm-pfizers-vaccine-prevention#:~:text=On%20March%2024%2C%202022%2C%20Pfizer,years%20of%20age%20and%20older">https://www.pfizer.com/news/press-release/press-release-detail/us-fda-approves-abrysvotm-pfizers-vaccine-prevention#:~:text=On%20March%2024%2C%202022%2C%20Pfizer,years%20of%20age%20and%20older</a>.</p><p class="pb-2">3. Steinzor P. Pfizer reports positive phase 3 results for RSV vaccine in immunocompromised adults. <em>AJMC. </em>August 15, 2024. Accessed October 23, 2024. <a target="_blank" href="https://www.ajmc.com/view/pfizer-reports-positive-phase-3-results-for-rsv-vaccine-in-immunocompromised-adults">https://www.ajmc.com/view/pfizer-reports-positive-phase-3-results-for-rsv-vaccine-in-immunocompromised-adults</a>.</p><p class="pb-2">4. Steinzor P. Updated ACIP guidelines: RSV vaccine for adults aged 60 years and older. <em>AJMC. </em>August 7, 2024. Accessed October 23, 2024. <a target="_blank" href="https://www.ajmc.com/view/updated-acip-guidelines-rsv-vaccine-for-adults-aged-60-years-and-older">https://www.ajmc.com/view/updated-acip-guidelines-rsv-vaccine-for-adults-aged-60-years-and-older</a>.</p><p class="pb-2">5. Abrysvo. Package insert. Pfizer Inc; 2024. Accessed October 23, 2024. <a rel="nofollow noreferrer noopener" target="_blank" href="https://labeling.pfizer.com/ShowLabeling.aspx?id=19589">https://labeling.pfizer.com/ShowLabeling.aspx?id=19589</a>.</p><p class="pb-2"></p><p class="pb-2"></p><p class="pb-2"></p><p class="pb-2"></p><p class="pb-2"></p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/exploring-the-differential-effectiveness-of-ics-by-smoking-status-in-copd"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="Alexander Mathioudakis, MD, PhD, clinical lecturer in respiratory medicine at The University of Manchester" title="Alexander Mathioudakis, MD, PhD, clinical lecturer in respiratory medicine at The University of Manchester" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain"/><noscript><img alt="Alexander Mathioudakis, MD, PhD, clinical lecturer in respiratory medicine at The University of Manchester" title="Alexander Mathioudakis, MD, PhD, clinical lecturer in respiratory medicine at The University of Manchester" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=30 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=30 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=30 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=30 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=30 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=30 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=30 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4aabbee95177fcd39517a945c70aed016dab6005-2814x1554.png%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=30" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%;object-fit:contain" loading="lazy"/></noscript></span></div><div class="w-full flex-wrap text-center text-sm mt-4 font-light no-underline text-white"></div></a><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/balancing-benefits-and-risks-of-amivantamab"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative bg-white aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="Joshua K. 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Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For the third episode in our special Pride Month series, we speak with Patrick McGovern, CEO of Callen-Lorde since August of 2023 and an outspoken advocate for HIV; lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+); and community health.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840.jpg?fit=crop&auto=format" alt="Nursing home care | Image credit: Kzenon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent">Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent">A Conversation on the Past, Present, and Future of Public Health: NPHW 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For National Public Health Week this year, we sat down with Kristen Krause, PhD, MPH, instructor in the Department of Urban-Global Public Health and deputy director, Center for Health, Identity, Behavior and Prevention Studies, Rutgers School of Public Health. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f366a4ab7421a6a697b539c22b8aedf46713899-6000x4000.jpg?fit=crop&auto=format" alt="FDA approval. | Image Credit: syahrir - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Zanidatamab-hrii for HER2+ Biliary Tract Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Currently, chemotherapy remains a common treatment for biliary tract cancers, which have a limited survival rate. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/39b5cd25fdc4e2947697c1fbad78955d026f6cc5-6000x4000.jpg?fit=crop&auto=format" alt="RSV risk survey | Image credit: Richelle - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent">Community Pharmacies Hold Key Role in Protecting Older Adults From RSV</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New research reveals gaps in respiratory syncytial virus (RSV) knowledge among older adults and emphasizes the impact community pharmacies can have at improving education and vaccine uptake.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent">Elevating Equitable Health Care for the LGBTQ+ Community</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-equitable-health-care-for-the-lgbtq-community?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For the third episode in our special Pride Month series, we speak with Patrick McGovern, CEO of Callen-Lorde since August of 2023 and an outspoken advocate for HIV; lesbian, gay, bisexual, transgender, queer, plus (LGBTQ+); and community health.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/316299cbd01bd7c3bfd4e4ae6e25c984d9f6cad1-5760x3840.jpg?fit=crop&auto=format" alt="Nursing home care | Image credit: Kzenon - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent">Low RSV Vaccination Rates in Nursing Homes Highlight Urgent Need for Uptake </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/low-rsv-vaccination-rates-in-nursing-homes-highlight-urgent-need-for-uptake?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9de113904a026205cbaf84d08420c4065d52fd67-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast logo" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 3rd 2023</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent">A Conversation on the Past, Present, and Future of Public Health: NPHW 2023</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/a-conversation-on-the-past-present-and-future-of-public-health-nphw-2023?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">For National Public Health Week this year, we sat down with Kristen Krause, PhD, MPH, instructor in the Department of Urban-Global Public Health and deputy director, Center for Health, Identity, Behavior and Prevention Studies, Rutgers School of Public Health. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2f366a4ab7421a6a697b539c22b8aedf46713899-6000x4000.jpg?fit=crop&auto=format" alt="FDA approval. | Image Credit: syahrir - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Zanidatamab-hrii for HER2+ Biliary Tract Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-zanidatamab-hrii-for-her2-biliary-tract-cancer?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Currently, chemotherapy remains a common treatment for biliary tract cancers, which have a limited survival rate. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/39b5cd25fdc4e2947697c1fbad78955d026f6cc5-6000x4000.jpg?fit=crop&auto=format" alt="RSV risk survey | Image credit: Richelle - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent">Community Pharmacies Hold Key Role in Protecting Older Adults From RSV</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/community-pharmacies-hold-key-role-in-protecting-older-adults-from-rsv?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">New research reveals gaps in respiratory syncytial virus (RSV) knowledge among older adults and emphasizes the impact community pharmacies can have at improving education and vaccine uptake.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"FDA Approves Abrysvo RSV Vaccine for Adults at Increased Risk \t","datePublished":"2024-10-23T16:33:44.716Z","dateModified":"2024-10-30T14:37:17Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/ec5d7f3ca4327cf6946c47b72824c06b31815c29-7680x4320.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/fda-approves-abrysvo-rsv-vaccine-for-adults-at-increased-risk"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"Abrysvo approval,RSV vaccine for adults,Pfizer RSV vaccine","articleBody":"The FDA has approved Pfizer’s respiratory syncytial virus (RSV) vaccine, Abrysvo, for adults aged 18 to 59 years who are at increased risk for the disease.1\n\n\n\n“RSV represents a significant threat to younger adults with certain chronic conditions,” Aamir Malik, chief US commercial officer and executive vice president, Pfizer, said in a statement. “After decades of vaccine research by the scientific community and Pfizer, we now have the opportunity to help alleviate the burden of RSV in this high-risk adult population. With this approval, we are proud that Abrysvo is now the only RSV vaccine indicated for adults aged 18 to 49 at increased risk for the disease, expanding on its existing indications for older adults and pregnant women.”\n\n\n\nOn March 24, 2022, the FDA granted Breakthrough Therapy Designation for Abrysvo for the prevention of lower respiratory tract disease (LRTD) caused by RSV in individuals aged 60 years and older.2 Since then, Pfizer has worked to expand the vaccine’s reach in immunocompromised adults. In August, Pfizer announced top-line results of Abrysvo being well-tolerated and effective in generating strong neutralizing responses in adults aged 18 years and older.3\n\n\n\nOn June 26, 2024, the CDC’s Advisory Committee on Immunization Practices (ACIP) updated its recommendations that all adults aged 75 and older and adults aged 60 to 74 years who are at increased risk for severe RSV should receive a single dose of the RSV vaccine (Arexvy [GSK], Abrysvo [Pfizer], or mResvia [Moderna]).4\n\n\n\nThe FDA’s most recent decision on Abrysvo is based on inferred efficacy from the pivotal phase 3 clinical trial (NCT05842967), which investigated the safety, tolerability, and immunogenicity of the vaccine in adults at risk of RSV-associated disease due to certain chronic medical conditions.1\n\n\n\nAmong all US adults aged 18 to 49 years, 9.5% have an underlying chronic condition, such as obesity, diabetes, chronic obstructive pulmonary disease (COPD), heart failure, chronic kidney disease, and asthma, putting them at increased risk of developing and being hospitalized for RSV-associated LRTD. This risk is exacerbated by 24.3% of all US adults aged 50 to 64.\n\n\n\nAbrysvo is indicated in the US for the prevention of LTRD caused by RSV in adults aged 60 years and older, the prevention of LTRD caused by RSV in adults aged 18 through 59 years who are at increased risk for LRTD caused by RSV, and pregnant individuals at 32 through 36 weeks gestational age for the prevention of LRTD and severe RSV caused by RSV in infants from birth through 6 months of age.\n\n\n\nThe most reported adverse reactions in pregnant individuals were pain at the injection site (40.6%), headache (31%), muscle pain (26.5%), and nausea (20%). In individuals aged 60 years and older, fatigue (15.7%), headache (12.9%), pain at the injection site (10.7%), and muscle pain (10.2%) were the most reported adverse reactions. Among those aged 18 through 59 years, the most common adverse reactions were pain at the injection site (35.3%), muscle pain (24.4%), joint pain (12.4%), and nausea (11.8%).5\n\n\n\n\n\nReferences\n\n1. US FDA approves Pfizer’s RSV vaccine Abrysvo for adults aged 18 to 59 at increased risk for disease. Pfizer Inc. News release. October 22, 2024. Accessed October 23, 2024. https://www.businesswire.com/news/home/20241018199265/en/U.S.-FDA-Approves-Pfizer%E2%80%99s-RSV-Vaccine-ABRYSVO%C2%AE-for-Adults-Aged-18-to-59-at-Increased-Risk-for-Disease.\n\n2. US FDA approves Abrysvo, Pfizer’s vaccine for the prevention of respiratory syncytial virus (RSV) in older adults. Pfizer Inc. News release. May 31, 2023. Accessed October 23, 2024. https://www.pfizer.com/news/press-release/press-release-detail/us-fda-approves-abrysvotm-pfizers-vaccine-prevention#:~:text=On%20March%2024%2C%202022%2C%20Pfizer,years%20of%20age%20and%20older.\n\n3. Steinzor P. Pfizer reports positive phase 3 results for RSV vaccine in immunocompromised adults. AJMC. August 15, 2024. Accessed October 23, 2024. https://www.ajmc.com/view/pfizer-reports-positive-phase-3-results-for-rsv-vaccine-in-immunocompromised-adults.\n\n4. Steinzor P. Updated ACIP guidelines: RSV vaccine for adults aged 60 years and older. AJMC. August 7, 2024. Accessed October 23, 2024. https://www.ajmc.com/view/updated-acip-guidelines-rsv-vaccine-for-adults-aged-60-years-and-older.\n\n5. Abrysvo. Package insert. Pfizer Inc; 2024. Accessed October 23, 2024. https://labeling.pfizer.com/ShowLabeling.aspx?id=19589.\n\n\n\n\n\n\n\n\n\n","description":"Abrysvo is the first and only respiratory syncytial virus (RSV) vaccine indicated for adults younger than 50 years. 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Shorla Oncology announces FDA approval of IMKELDI (imatinib) oral solution, an oral liquid for the treatment of certain forms of leukemia and other cancers. News release. Shorla Oncology. November 25, 2024. Accessed November 26, 2024. ","_key":"fcc66983d1cc0"},{"_type":"span","marks":["ae7780cb14be"],"text":"https://www.businesswire.com/news/home/20241125044117/en/Shorla-Oncology-Announces-FDA-Approval-of-IMKELDI-imatinib-Oral-Solution-an-Oral-Liquid-for-the-Treatment-of-Certain-Forms-of-Leukemia-and-Other-Cancers","_key":"fcc66983d1cc1"}]},{"children":[{"_key":"7118d79650890","_type":"span","marks":[],"text":"2. Key statistics for acute lymphoblastic leukemia (ALL). American Cancer Society. Updated January 17, 2024. Accessed November 26, 2024. 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He brings to this role a wealth of experience and a lifetime of advocacy, including as chief operations and strategy officer at Amida Care, CEO of Harlem United Community AIDS Center, and vice president of government affairs at Gilead.","_key":"12f45ecf7b37"}],"_type":"block","style":"normal","_key":"0fab62a8f58b"},{"style":"normal","_key":"7b26dc79605e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7cda526332a1"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"\"My career has really been dedicated to providing equitable health care for people that our mainstream health care systems have often neglected,\" McGovern states. \"As a gay man myself, I know firsthand that LGBTQ+ people and people living with HIV often have to take care of ourselves in a society that's pushed us to the margin and I think, at times, demonized us.\"","_key":"d6507ad5e8fa"}],"_type":"block","style":"normal","_key":"1531ce6fcc6d","markDefs":[]},{"markDefs":[],"children":[{"_key":"21ef8eb4648e","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"66aa548de8cd"},{"_type":"iframe","_key":"010bb9e5e8d9","url":"https://w.soundcloud.com/player/?url=https%3A//api.soundcloud.com/tracks/1846709367%3Fsecret_token%3Ds-EbllearkTQE\u0026color=%23ff5500\u0026auto_play=false\u0026hide_related=false\u0026show_comments=true\u0026show_user=true\u0026show_reposts=false\u0026show_teaser=true\u0026visual=true"},{"_type":"block","style":"normal","_key":"3eb6f6f07cbf","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Listen above or through one of these podcast services:","_key":"98bb828a4ac5"}]},{"markDefs":[{"_type":"link","href":"https://podcasts.apple.com/us/podcast/managed-care-cast/id1177540313","_key":"ed6c96e89972","nofollow":true,"blank":true},{"href":"https://tunein.com/podcasts/Health--Wellness-Podcasts/Managed-Care-Cast-p937637/","_key":"3c7fa5391346","nofollow":true,"blank":true,"_type":"link"},{"nofollow":true,"blank":true,"_type":"link","href":"https://www.stitcher.com/podcast/managed-care-cast","_key":"e17aabd22bda"},{"blank":true,"_type":"link","href":"https://open.spotify.com/show/7JQZGTuflqnkt8wjfX238y","_key":"fbae5a9f2410","nofollow":true}],"children":[{"text":"iTunes","_key":"1e8dca99b8d1","_type":"span","marks":["ed6c96e89972"]},{"_type":"span","marks":[],"text":"\n","_key":"e0a9c3bda6dd"},{"_type":"span","marks":["3c7fa5391346"],"text":"TuneIn","_key":"041f84fb2986"},{"_type":"span","marks":[],"text":"\n","_key":"d846254e8263"},{"marks":["e17aabd22bda"],"text":"Stitcher","_key":"b2f92d8b0b90","_type":"span"},{"_type":"span","marks":[],"text":"\n","_key":"a33bb0f99207"},{"_type":"span","marks":["fbae5a9f2410"],"text":"Spotify","_key":"9fe637c78af3"}],"_type":"block","style":"normal","_key":"b499eca67c46"}],"contentCategory":{"_createdAt":"2020-04-03T20:07:37Z","_rev":"DuxacMYwkIxWPw8NDZCeiZ","_type":"contentCategory","name":"Podcasts","disableAds":false,"_id":"367becaf-13c4-4502-9c8c-939f4f480898","_updatedAt":"2021-08-12T18:05:19Z"},"documentGroupMapping":null,"_id":"225723ef-9415-4a3f-96a7-52945c54ca71","seoTag":["Callen-Lorde","Callen-Lorde Community Health Center","Amida Care"],"url":"elevating-equitable-health-care-for-the-lgbtq-community","_createdAt":"2024-06-13T18:00:09Z","authorMapping":[{"_rev":"4vyIlJfwMwqB8NbLEufdwW","_updatedAt":"2024-08-07T15:47:36Z","url":{"current":"maggie-l-shaw","_type":"slug"},"displayName":"Maggie L. 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Influenza and RSV vaccination data were reported voluntarily, while COVID-19 vaccination reporting was mandatory.","_key":"6aa20a28c07f"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"6aa9a95312e70","_type":"span","marks":[],"text":"\nVaccination coverage among nursing home residents was reported by 51.8% of facilities, with only 17.9% of residents receiving the vaccine. Coverage varied widely by region, from 9.3% in HHS Region 6 to 29.2% in HHS Region 8, and was highest in counties with lower social vulnerability (21.3%) and in smaller facilities (24.1%)."}],"_type":"block","style":"normal","_key":"242200872a9c"},{"style":"normal","_key":"4f23d31519ae","markDefs":[],"children":[{"text":"","_key":"a3b4712b0f6f0","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"655c13299ace","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Influenza vaccination coverage was voluntarily reported by 59.4% of facilities, with 58.4% of residents vaccinated. Coverage ranged from 50.9% in HHS Region 10 to 64.1% in HHS Region 1 and was higher in the least socially vulnerable counties (60.8%) and smaller facilities (62.9%).","_key":"6d6e2e1e43230"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9b05c96fb9c70"}],"_type":"block","style":"normal","_key":"ef79beabf256"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"COVID-19 vaccination coverage, which was reported by 92.9% of facilities, remained low, with only 29.7% of residents receiving the 2024 to 2025 COVID-19 vaccine. Coverage was lowest in HHS Region 6 (19.8%) and highest in Region 8 (38.6%), with better rates observed in smaller facilities (34.7%) and less vulnerable counties (33.6%). These findings highlight substantial gaps in vaccine uptake, particularly for RSV and COVID-19.","_key":"2e9941b21abf0"}],"_type":"block","style":"normal","_key":"e026ae7211c9"},{"style":"normal","_key":"54cc79d7a6ea","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b61eb94f9e580"}],"_type":"block"},{"children":[{"marks":[],"text":"However, the investigators noted some limitations. First, reporting of influenza and RSV vaccination coverage was voluntary, and facilities that chose to report may have had higher vaccination rates than those that did not, potentially biasing the results. Second, the increase in the number of facilities reporting influenza and RSV vaccination coverage compared with the previous season limited direct comparisons between seasons. Third, RSV vaccination coverage was calculated for residents of all ages, although approximately 91% of nursing home residents are aged 60 years and older, for whom the vaccine is recommended. 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Reses HE, Segovia G, Dubendris H, et al. Coverage with influenza, respiratory syncytial virus, and COVID-19 vaccines among nursing home residents — National Healthcare Safety Network, United States, November 2024. "},{"_type":"span","marks":["em"],"text":"MMWR Morb Mortal Wkly Rep.","_key":"7b8f957b8f2e1"},{"_type":"span","marks":[],"text":" 2024;73:1052-1057. doi:","_key":"7b8f957b8f2e2"},{"marks":["0b631d436eed"],"text":"http://dx.doi.org/10.15585/mmwr.mm7346a2","_key":"7b8f957b8f2e3","_type":"span"}],"_type":"block"},{"markDefs":[{"href":"https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/older-adults.html","_key":"025b5ce4476d","nofollow":true,"blank":true,"_type":"link"}],"children":[{"_type":"span","marks":[],"text":"2. RSV vaccine guidance for older adults. CDC. August 30, 2024. Accessed November 22, 2024. ","_key":"194262328b8a0"},{"_key":"194262328b8a1","_type":"span","marks":["025b5ce4476d"],"text":"https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/older-adults.html"}],"_type":"block","style":"normal","_key":"20ab0a0618e5"},{"_type":"block","style":"normal","_key":"d83158e2a1a2","markDefs":[],"children":[{"text":"","_key":"572013791b050","_type":"span","marks":[]}]}],"is_visible":true,"_type":"article","documentGroupMapping":null,"authorMapping":[{"firstName":"Pearl ","lastName":"Steinzor","displayName":"Pearl Steinzor","_rev":"r4x1XD7WYsdf9YL1ZVgDGC","_type":"author","_id":"8f51e09f-2c76-4ef0-83e7-d577a5dfcdd1","_createdAt":"2022-10-05T15:22:49Z","profileImage":{"_type":"mainImage","alt":"Pearl Steinzor","asset":{"_ref":"image-aaad3972f041cf080c4994a923d62017c74f0ac3-512x512-jpg","_type":"reference"}},"_updatedAt":"2024-10-25T15:48:33Z","url":{"current":"pearl-steinzor","_type":"slug"}}],"summary":"Significant gaps in vaccination coverage among nursing home residents leaves vulnerable populations at risk for severe complications, report finds. 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While targeted therapies exist for biliary tract cancers, chemotherapy remains a highly common treatment for patients.","_key":"6ad1953cfa11"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"9c65b9f0059d0"}],"_type":"block","style":"normal","_key":"5c94e13abbe0","markDefs":[]},{"_key":"8da0979b9516","markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"Metastatic biliary tract cancer, BTC [biliary tract cancer], places a significant burden on patients, affecting their quality of life and their emotional and mental well-being, as well as that of their families,\" Stacie Lindsey, chief executive officer and founder of the Cholangiocarcinoma Foundation, said in a press release.","_key":"feccfa5a708e0"},{"_type":"span","marks":["superscript"],"text":"1","_key":"aa46be63f42a"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"","_key":"683fc781e2860","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"d4ab63b4c4f9"},{"children":[{"marks":[],"text":"The study enrolled 87 patients with HER2-amplified, locally advanced unresectable or metastatic biliary tract cancer in 2 cohorts. Patients received 20 mg/kg zanidatamab intravenously every 2 weeks until disease progression or unacceptable toxicity, for an average of 5.6 months.","_key":"599212f17bd30","_type":"span"}],"_type":"block","style":"normal","_key":"447c1e6e2b86","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"d442a9a823c40"}],"_type":"block","style":"normal","_key":"303f274b5373","markDefs":[]},{"_type":"block","style":"normal","_key":"94543a8c3ac9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The first cohort included patients who were immunohistochemistry (IHC) 2+/3+ (n = 80) while the second cohort included patients who were IHC 0/1+ (n = 7). Tumors were reassessed every 8 weeks. Primary end points included the objective response rate by independent central review in cohort 1 while efficacy and safety outcomes were the secondary end points.","_key":"4ffa0fde190d0"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4d860110db270"}],"_type":"block","style":"normal","_key":"bb3964ecd099"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“Zanidatamab has demonstrated antitumor activity and is now a new option for patients with HER2-positive biliary tract cancer,” commented James Harding, MD, gastrointestinal oncologist and early drug development specialist at Memorial Sloan Kettering Cancer Center.","_key":"43405c812f820"},{"_type":"span","marks":["superscript"],"text":"1","_key":"bb246e09b399"}],"_type":"block","style":"normal","_key":"397b5e99afc6"},{"markDefs":[],"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"bd936c277c0e"}],"_type":"block","style":"normal","_key":"47b6bf634538"},{"_key":"82e3f7567cca","markDefs":[{"blank":true,"_type":"link","href":"https://clinicaltrials.gov/study/NCT06282575?term=NCT06282575\u0026rank=1","_key":"718dbb375962","nofollow":true}],"children":[{"_type":"span","marks":[],"text":"The accelerated approval of zanidatamab was granted based on the 52% objective response rate among patients, as well as the 14.9 months average duration of treatment. 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Only 1 patient had a fatal adverse reaction of hepatic failure and 2.5% of patients permanently discontinued due to adverse reactions.","_key":"a20e77ccb2790"}]},{"_type":"block","style":"normal","_key":"6b64593f4ab0","markDefs":[],"children":[{"text":"","_key":"588170b38d2c0","_type":"span","marks":[]}]},{"_type":"block","style":"normal","_key":"b0df167c5067","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Zanidatamab is currently being investigated for its potential in treating additional tumor types. Phase 3 trials are underway to explore its efficacy in gastroesophageal adenocarcinomas (GEAs) and metastatic breast cancer. 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A recent study in this patient population found that RSV vaccination was 77% to 81% effective against associated critical illness, hospitalization, and emergency department encounters in the 2023-2024 season.","_key":"81dc5f0e7c830"},{"_type":"span","marks":["superscript"],"text":"2","_key":"ff51678ff454"},{"_type":"span","marks":[],"text":" This marked the first RSV season following the release of the approved vaccines, emphasizing their success.","_key":"739854e4ee09"}],"_type":"block","style":"normal"},{"_key":"a1a99476305f","markDefs":[],"children":[{"_key":"a3cc09bcf04b0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"83e1d5c07d84","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the present study, the researchers aimed to evaluate patient knowledge about RSV and to provide patients with information about the virus and the vaccination.","_key":"99be1821783a0"},{"_type":"span","marks":["superscript"],"text":"1","_key":"303a43d706a1"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"c8b2b5cee16c0","_type":"span"}],"_type":"block","style":"normal","_key":"70071e696e24"},{"style":"normal","_key":"51b5ce20533a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The study was conducted across 4 independent community pharmacy sites from September 12, 2023, to March 11, 2024. Participants 60 years or older were invited to complete a 14-question survey designed to assess their knowledge of RSV and their willingness to receive the RSV vaccine. Survey questions covered demographics, long-term health conditions, knowledge about RSV transmission and prevention, prior education from health care providers, and vaccine acceptance or refusal.","_key":"8fe2e45281670"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"820091a2a9bb0"}],"_type":"block","style":"normal","_key":"56b5e5dad1fa"},{"children":[{"_key":"3d769b3c77370","_type":"span","marks":[],"text":"Participants received an educational handout developed by site pharmacists using CDC guidelines and were offered verbal counseling to support shared decision-making about vaccination. Vaccines were administered on site for participants who consented, regardless of whether they opted for counseling. Data from the anonymous surveys were analyzed using descriptive statistics to evaluate participants’ understanding of RSV, sources of prior knowledge, and factors influencing vaccine uptake or refusal."}],"_type":"block","style":"normal","_key":"0f64a8bcc5ce","markDefs":[]},{"style":"normal","_key":"88c86c43cf0a","markDefs":[],"children":[{"marks":[],"text":"","_key":"69a7a03f17a00","_type":"span"}],"_type":"block"},{"_type":"block","style":"normal","_key":"fa02a8e952e7","markDefs":[],"children":[{"marks":[],"text":"The study included 518 participants, with most aged 71 to 80 years (48%), female (61%), and White (87%) and non-Hispanic (81%). Among them, 61% reported having long-term health conditions, with cardiovascular disease (49%) and lung disease (21%) being the most common. ","_key":"49b1b97d71a00","_type":"span"}]},{"style":"normal","_key":"f7e9df887c50","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"990062151e9d0"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The primary outcome revealed significant gaps in RSV knowledge, with 78% of participants reporting having never received RSV education from health care providers, although 70% correctly identified its transmission methods. Additionally, 60% of participants understood how to protect themselves, and 58% recognized that prior infection does not confer immunity.","_key":"3a6f631b58d60"}],"_type":"block","style":"normal","_key":"47d6886e9d4c"},{"children":[{"_key":"fb54382e9ceb0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"f82eb08d1e72","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Regarding vaccination, 63% of participants opted to receive the RSV vaccine on site after completing the survey. 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The study's small geographic scope limited the generalizability of its results to broader community pharmacy settings, and inconsistencies in pharmacist presence and engagement due to the residents’ limited availability at each site further challenged the uniformity of survey delivery and participant interaction.","_key":"c4a42a3e7b300"}],"_type":"block"},{"_type":"block","style":"normal","_key":"347724a9cb11","markDefs":[],"children":[{"marks":[],"text":"","_key":"bbdd8ae1a77d0","_type":"span"}]},{"children":[{"_type":"span","marks":[],"text":"Despite these limitations, the researchers believe the study findings provide valuable insights on the knowledge and attitudes toward RSV and its vaccine in an older adult population.","_key":"e64624eea1b40"}],"_type":"block","style":"normal","_key":"6984977866b1","markDefs":[]},{"_type":"block","style":"normal","_key":"ffd3b1d2a6dc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"80c9cea6363d0"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"“The willingness to receive the RSV vaccine was relatively high among participants who received verbal counseling and education from a pharmacist along with the educational handout, although vaccine hesitancy remains a barrier,” wrote the researchers. “This study emphasizes the critical role of a community pharmacist in health care delivery and the need for enhanced educational efforts to support vaccination programs and shared clinical health care decision-making.”","_key":"eb0ebfab49f60"}],"_type":"block","style":"normal","_key":"70267fc737b5"},{"_key":"900efd58f031","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"482e867c6e6a0"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"97d1035d24470"}],"_type":"block","style":"normal","_key":"6a0f54d7ecd0","markDefs":[]},{"style":"normal","_key":"dc007556e5cb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"1. 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