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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-286612495 content-wrap"><span class="jsx-286612495 py-3 text-sm text-gray-500 text-left"><i class="jsx-286612495">June 2nd 2018</i></span><div class="jsx-286612495 w-full h-fit mb-4"><p class="jsx-286612495 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Podcast: This Week in Managed Care&mdash;Bringing Down Health Insurance Premiums and Other Health News</p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center 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href="/view/cancer-drugs-speed-to-accelerated-approvals-then-hit-the-brakes-in-timely-clinically-beneficial-confirmatory-trials"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nivolumab-plus-ipilimumab-proves-less-costly-than-rival-combo-over-2-years-in-advanced-renal-cell-carcinoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d215590e0eab6a8957d43e6ebbacef33b7287624-1332x676.jpg?fit=crop&auto=format" alt="Nivolumab and Ipilimumab | Image credit: Bristol Myers Squibb" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nivolumab-plus-ipilimumab-proves-less-costly-than-rival-combo-over-2-years-in-advanced-renal-cell-carcinoma">Nivolumab Plus Ipilimumab Proves Less Costly Than Rival Combo Over 2 Years in Advanced Renal Cell Carcinoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nivolumab-plus-ipilimumab-proves-less-costly-than-rival-combo-over-2-years-in-advanced-renal-cell-carcinoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The immunotherapy combination was initially more costly but resulted in a lower cost 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class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/-personalized-immunotherapy-appears-effective-in-small-study-of-patients-with-metastatic-solid-tumors"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/160860b3e04088928d435126a54965ee805c43d7-1022x594.webp?fit=crop&auto=format" alt="White Blood Cells | Image credit: Adobe Stock" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/-personalized-immunotherapy-appears-effective-in-small-study-of-patients-with-metastatic-solid-tumors">“Personalized” Immunotherapy Appears Effective in Small Study of Patients With Metastatic Solid Tumors</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/-personalized-immunotherapy-appears-effective-in-small-study-of-patients-with-metastatic-solid-tumors"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A small trial by investigators at the National Cancer Institute holds promise to bring personalized cell therapy into the solid tumor arena, after more than a decade of success in blood cancers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-finds-link-between-vitamin-d-levels-at-start-of-immunotherapy-and-overall-survival"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a62f2ea5079c97bdd1b394587a6d0bee1ed5ad35-750x500.webp?fit=crop&auto=format" alt="Vitamin D | Image credit: Getty Images" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 3rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-link-between-vitamin-d-levels-at-start-of-immunotherapy-and-overall-survival">Study Finds Link Between Vitamin D Levels at Start of Immunotherapy and Overall Survival</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-finds-link-between-vitamin-d-levels-at-start-of-immunotherapy-and-overall-survival"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Researchers from the University of Manchester sought to understand whether the season of administration of immunotherapy affected outcomes.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/preclinical-study-shows-promise-of-dual-targeted-treatment-against-tnbc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/aaa69353b712ffb322c78de00d76082845a76bfd-1200x628.jpg?fit=crop&auto=format" alt="representation of targeted treatment | Image Credit: Kiattisak-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/preclinical-study-shows-promise-of-dual-targeted-treatment-against-tnbc">Preclinical Study Shows Promise of Dual Targeted Treatment Against TNBC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/preclinical-study-shows-promise-of-dual-targeted-treatment-against-tnbc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Early findings from a new preclinical study indicate that dual blockade of aurora-A kinase and PD-L1 signaling can inhibit tumor growth in triple-negative breast cancer (TNBC), treatment for which has historically remained limited. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-pembrolizumab-with-chemotherapy-in-advanced-endometrial-carcinoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/98e680a2cbc02e30ff14be9842085795cdfd8021-1200x724.jpg?fit=crop&auto=format" alt="FDA Approved Products or Drugs-Olivier Le Moal-stock.adobe.com.jpeg" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-pembrolizumab-with-chemotherapy-in-advanced-endometrial-carcinoma">FDA Approves Pembrolizumab With Chemotherapy in Advanced Endometrial Carcinoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-pembrolizumab-with-chemotherapy-in-advanced-endometrial-carcinoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approved pembrolizumab (Keytruda) plus carboplatin and paclitaxel, followed by single-agent pembrolizumab, in adult patients with primary advanced or recurrent endometrial carcinoma.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-plus-chemotherapy-receives-approval-for-dmmr-primary-advanced-or-recurrent-endometrial-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/98e680a2cbc02e30ff14be9842085795cdfd8021-1200x724.jpg?fit=crop&auto=format" alt="Blue FDA Approved stamp | Image credit: Olivier Le Moal - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-plus-chemotherapy-receives-approval-for-dmmr-primary-advanced-or-recurrent-endometrial-cancer">Durvalumab Plus Chemotherapy Receives Approval for dMMR Primary Advanced or Recurrent Endometrial Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/chris-ryan">Chris Ryan</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-plus-chemotherapy-receives-approval-for-dmmr-primary-advanced-or-recurrent-endometrial-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA has approved durvalumab combined with carboplatin and paclitaxel, followed by single-agent durvalumab.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/blinatumomab-approved-in-consolidation-phase-for-cd-19-ph-negative-precursor-b-all-redefines-standard-of-care-"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b6a0150489f6123a9aa44b0c959641d60b37228b-396x127.png?fit=crop&auto=format" alt="Blinatumomab logo | Image credit: Amgen" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">Published: June 14th 2024 | Updated: June 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/blinatumomab-approved-in-consolidation-phase-for-cd-19-ph-negative-precursor-b-all-redefines-standard-of-care-">Blinatumomab Approved in Consolidation Phase for CD-19+ Ph-Negative Precursor B-ALL, “Redefines Standard of Care”</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/blinatumomab-approved-in-consolidation-phase-for-cd-19-ph-negative-precursor-b-all-redefines-standard-of-care-"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Bringing the bispecific T-cell engager into the frontline consolidation phase "redefines the standard of care" for patients with B-ALL, an investigator said.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/tislelizumab-plus-chemo-meaningfully-improves-os-pfs-in-advanced-esophageal-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/fbf4843e4849c99f2cbfad6e2c104eedcd60476c-1280x853.jpg?fit=crop&auto=format" alt="Esophageal cancer illustration | Image credit: Dr_Microbe - stockadobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/tislelizumab-plus-chemo-meaningfully-improves-os-pfs-in-advanced-esophageal-cancer">Tislelizumab Plus Chemo Meaningfully Improves OS, PFS in Advanced Esophageal Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/tislelizumab-plus-chemo-meaningfully-improves-os-pfs-in-advanced-esophageal-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The results of the 3-year follow-up show meaningful improvement in overall survival (OS) and progression-free survival (PFS) for tislelizumab plus chemotherapy compared with placebo plus chemotherapy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/whither-car-t-will-the-fda-being-under-the-hood-and-the-availability-of-bispecifi-cs-make-these-therapies-less-attractive-"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6de7f7c13942b90bfa6f3f8c592f39972b319b79-600x522.jpg?fit=crop&auto=format" alt="CAR T-cell therapy | Image credit: Getty Images Science Library" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/whither-car-t-will-the-fda-being-under-the-hood-and-the-availability-of-bispecifi-cs-make-these-therapies-less-attractive-">Whither CAR T? Will the FDA Being Under the Hood and the Availability of Bispecifics Make These Therapies Less Attractive?</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/sang-chau-pharmd-bcop">Sang Chau, PharmD, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/justin-tse-pharmd-bcop">Justin Tse, PharmD, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/amy-vangalder-pharmd-bcop">Amy VanGalder, PharmD, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/garrick-wong-pharmd">Garrick Wong, PharmD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/terra-wonsettler-pharmd-mba">Terra Wonsettler, PharmD, MBA</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/andrew-hertler-md-facp">Andrew Hertler, MD, FACP</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/whither-car-t-will-the-fda-being-under-the-hood-and-the-availability-of-bispecifi-cs-make-these-therapies-less-attractive-"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-christopher-flowers-liso-cel-approval-for-mantle-cell-lymphoma-changes-the-treatment-strategy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8f5bba48b553a1c13d9623cb39764b01b3065056-1280x854.jpg?fit=crop&auto=format" alt="Older male patient speaking with doctor | Image credit: DragonImages - adobe.stock.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 7th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-christopher-flowers-liso-cel-approval-for-mantle-cell-lymphoma-changes-the-treatment-strategy">Dr Christopher Flowers: Liso-Cel Approval for Mantle Cell Lymphoma Changes the Treatment Strategy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-christopher-flowers-liso-cel-approval-for-mantle-cell-lymphoma-changes-the-treatment-strategy"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The latest approval of lisocabtagene maraleucel (liso-cel) in mantle cell lymphoma provides another treatment option and continues the tremendous advances in treatment for patients, said Christopher Flowers, MD, of MD Anderson Cancer Center.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-liso-cel-to-treat-r-r-mantle-cell-lymphoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/52a462ff15754948c23a68a2d0eb59cce9d156b8-250x250.png?fit=crop&auto=format" alt="Breyanzi packaging | Image credit: BMS" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-liso-cel-to-treat-r-r-mantle-cell-lymphoma">FDA Approves Liso-Cel to Treat R/R Mantle Cell Lymphoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-liso-cel-to-treat-r-r-mantle-cell-lymphoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Mantle cell lymphoma is the fourth subtype of non-Hodgkin lymphoma that can be treated with this CAR T-cell therapy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/bringing-the-human-factor-to-the-last-mile-of-ai-assisted-clinical-decisions"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/00232e56f99766fa712e119744fff350e4c9c3bf-512x512.png?fit=crop&auto=format" alt="Rajni Natesan, MD, MBA | Image credit: Clarified Precision Medicine" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/bringing-the-human-factor-to-the-last-mile-of-ai-assisted-clinical-decisions">Bringing the Human Factor to the “Last Mile” of AI-Assisted Clinical Decisions</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/bringing-the-human-factor-to-the-last-mile-of-ai-assisted-clinical-decisions"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-receives-accelerated-approval-for-extensive-stage-sclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/db6c88afb196508d8ce41e2f72273ee54168e353-6000x4000.jpg?fit=crop&auto=format" alt="Doctor with health care icons and FDA | Image credit: wladimir1804 - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-receives-accelerated-approval-for-extensive-stage-sclc">Tarlatamab Receives Accelerated Approval for Extensive-Stage SCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/tarlatamab-receives-accelerated-approval-for-extensive-stage-sclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA has approved tarlatamab (Imdelltra; Amgen), a novel bispecific T-cell engager, to treat patients with extensive-stage small cell lung cancer (SCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/perioperative-nivolumab-boosts-nsclc-survival-checkmate-77t-trial"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/969c271792d495b33482fa8ee8c2cfc81b026c18-1200x800.jpg?fit=crop&auto=format" alt="Lung cancer diagnosis concept | Image Credit: VitaliiVodolazskyi-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/perioperative-nivolumab-boosts-nsclc-survival-checkmate-77t-trial">Perioperative Nivolumab Boosts NSCLC Survival: CheckMate 77T Trial</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/perioperative-nivolumab-boosts-nsclc-survival-checkmate-77t-trial"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This interim analysis of the CheckMate 77T trial, outcomes were compared between adult patients receiving neoadjuvant nivolumab plus chemotherapy or neoadjuvant chemotherapy plus placebo for resectable non–small cell lung cancer (NSCLC). </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-grants-accelerated-approval-for-liso-cel-for-r-r-follicular-lymphoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c63ff47c1467e85a31d65a8f0b631f6f76ce285e-3873x3873.jpg?fit=crop&auto=format" alt="U.S. Food and Drug Administration FDA approved | Calin - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-grants-accelerated-approval-for-liso-cel-for-r-r-follicular-lymphoma">FDA Grants Accelerated Approval for Liso-Cel for R/R Follicular Lymphoma </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/pearl-steinzor">Pearl Steinzor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-grants-accelerated-approval-for-liso-cel-for-r-r-follicular-lymphoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">FDA has given accelerated approval for lisocabtagene maraleucel (liso-cel; Breyanzi) for patients with relapsed or refractory (R/R) follicular lymphoma. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/postsurgical-pembrolizumab-and-chemo-with-or-without-radiotherapy-falls-short-in-phase-3-trial-for-newly-diagnosed-high-risk-endometrial-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/11f57e53688c459a204005b522e775413b30da03-600x450.jpg?fit=crop&auto=format" alt="Keytruda packaging | Image credit: Merck" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/postsurgical-pembrolizumab-and-chemo-with-or-without-radiotherapy-falls-short-in-phase-3-trial-for-newly-diagnosed-high-risk-endometrial-cancer">Postsurgical Pembrolizumab and Chemo, With or Without Radiotherapy, Falls Short in Phase 3 Trial for Newly Diagnosed, High-Risk Endometrial Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/postsurgical-pembrolizumab-and-chemo-with-or-without-radiotherapy-falls-short-in-phase-3-trial-for-newly-diagnosed-high-risk-endometrial-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Pembrolizumab has existing indications in endometrial cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-accepts-nivolumab-subcutaneous-injection-application-with-potential-to-boost-access-to-pd-1-inhibitors"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/020de2a739acebd5b1504eaae11472ee817989eb-880x588.webp?fit=crop&auto=format" alt="Opdivo packaging | Image credit: Bristol Myers Squibb" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">Published: May 9th 2024 | Updated: May 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-accepts-nivolumab-subcutaneous-injection-application-with-potential-to-boost-access-to-pd-1-inhibitors">FDA Accepts Nivolumab Subcutaneous Injection Application, With Potential to Boost Access to PD-1 Inhibitors</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-accepts-nivolumab-subcutaneous-injection-application-with-potential-to-boost-access-to-pd-1-inhibitors"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Some experts believe offering a subcutaneous version of nivolumab could make PD-1 inhibitors available to new groups of patients who currently lack access, such as those in rural areas.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-shows-potential-for-using-nivolumab-plus-relatlimab-before-surgery-in-nsclc"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/158f6f276bd6a814e28cd34dde881dd389dd0de0-400x400.jpg?fit=crop&auto=format" alt="Nature Medicine logo | Image credit: Nature Medicine" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 4th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-shows-potential-for-using-nivolumab-plus-relatlimab-before-surgery-in-nsclc">Study Shows Potential for Using Nivolumab Plus Relatlimab Before Surgery in NSCLC</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-shows-potential-for-using-nivolumab-plus-relatlimab-before-surgery-in-nsclc"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Authors discuss the merits of using a pair of immunotherapy treatments aimed at separate targets.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/t-cell-exhaustion-in-cll-allogeneic-car-t-trial-reaching-patients-with-unmet-need"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c66037bf1069204334e5f504aa2305893a135a61-203x203.png?fit=crop&auto=format" alt="Javier Pinilla-Ibarz, MD, PhD | Image credit: Targeted Oncology" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/t-cell-exhaustion-in-cll-allogeneic-car-t-trial-reaching-patients-with-unmet-need">T-Cell Exhaustion in CLL: Allogeneic CAR T Trial Reaching Patients With Unmet Need</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/t-cell-exhaustion-in-cll-allogeneic-car-t-trial-reaching-patients-with-unmet-need"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">"Off the shelf" CAR T-cell therapies could offer a solution in chronic lymphocytic leukemia, where T-cell exhaustion creates treatment challenges. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nogapendekin-alfa-inbakicept-with-bcg-approved-for-type-of-bladder-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cd32c5fba4cd303ebf7f976915f7928c85c7e641-335x360.jpg?fit=crop&auto=format" alt="Anktiva packaging | Image credit: ImmunityBio" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nogapendekin-alfa-inbakicept-with-bcg-approved-for-type-of-bladder-cancer">Nogapendekin Alfa Inbakicept With BCG Approved for Type of Bladder Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nogapendekin-alfa-inbakicept-with-bcg-approved-for-type-of-bladder-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The principal investigator of the study leading to approval said this new immunotherapy could be a "game changer" in bladder cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/young-woman-with-rare-cervical-cancer-achieves-remission-after-nivolumab-before-chemoradiotherapy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/db77eee0e68f3d84e1edb9842f18ffff98373e63-460x341.jpg?fit=crop&auto=format" alt="Clear cell carcinoma | Image credit: Sunnybrook Health Sciences Center" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/young-woman-with-rare-cervical-cancer-achieves-remission-after-nivolumab-before-chemoradiotherapy">Young Woman With Rare Cervical Cancer Achieves Remission After Nivolumab Before Chemoradiotherapy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/young-woman-with-rare-cervical-cancer-achieves-remission-after-nivolumab-before-chemoradiotherapy"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A tumor board looked to studies in ovarian cancer for guidance on use of immunotherapy in a rare case of clear cell carcinoma of the cervix.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-health-care-antitrust-portal-car-t-label-updates-weight-loss-shots-and-fertility"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/703de894e882d8a6da8c19964dc1ca71b969d30c-2000x1046.png?fit=crop&auto=format" alt="what we're reading logo" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-health-care-antitrust-portal-car-t-label-updates-weight-loss-shots-and-fertility">What We’re Reading: Health Care Antitrust Portal; CAR T Label Updates; Weight-Loss Shots and Fertility</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/what-we-re-reading-health-care-antitrust-portal-car-t-label-updates-weight-loss-shots-and-fertility"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Government agencies have created an online portal for the public to report potential anticompetitive practices in health care; there are changes coming to the “boxed warning” section for chimeric antigen receptor T-cell therapies (CAR T) to highlight T-cell blood cancer risk; questions about the safety of obesity medications during pregnancy have arisen in women on them who previously struggled with fertility issues.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/starglo-glofitamab-plus-chemo-meets-primary-os-endpoint-in-r-r-dlbcl-in-phase-3-study"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1b8035d8cfccc4a0cf96de0d966566e4bddbbbaa-600x337.webp?fit=crop&auto=format" alt="Columvi packaging | Image: Genentech" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/starglo-glofitamab-plus-chemo-meets-primary-os-endpoint-in-r-r-dlbcl-in-phase-3-study">STARGLO: Glofitamab Plus Chemo Meets Primary OS End Point in R/R DLBCL in Phase 3 Study</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/starglo-glofitamab-plus-chemo-meets-primary-os-endpoint-in-r-r-dlbcl-in-phase-3-study"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Results show the bispecific antibody is effective in an earlier line of treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/health-care-practitioners-push-for-legislative-solution-to-prevent-chemotherapy-shortage-groundhog-day-"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0723758cc83d02a7256e488e9500ee675daa995f-480x240.png?fit=crop&auto=format" alt="AJMC EBO logo | Image credit : AJMC" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/health-care-practitioners-push-for-legislative-solution-to-prevent-chemotherapy-shortage-groundhog-day-">Health Care Practitioners Push for Legislative Solution to Prevent Chemotherapy Shortage “Groundhog Day”</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ryan-flinn">Ryan Flinn</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/health-care-practitioners-push-for-legislative-solution-to-prevent-chemotherapy-shortage-groundhog-day-"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/how-does-metabolic-tumor-volume-affect-responses-to-axi-cel-in-lbcl-"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8bdef21574c36f8959fb60201088167c907bd627-359x449.png?fit=crop&auto=format" alt="Fred Locke, MD | Image credit: Moffitt Cancer Center" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 3rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/how-does-metabolic-tumor-volume-affect-responses-to-axi-cel-in-lbcl-">How Does Metabolic Tumor Volume Affect Responses to Axi-Cel in LBCL?</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/how-does-metabolic-tumor-volume-affect-responses-to-axi-cel-in-lbcl-"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The authors say a standard method of assessing metabolic tumor volume would be needed for its use to become widespread.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/florida-cancer-specialists-research-institute-forms-analytics-subsidiary"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/638756edbe3879aa4deb83066d7c571e652e215a-625x179.jpg?fit=crop&auto=format" alt="FCS logo | Image credit: FCS" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 2nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/florida-cancer-specialists-research-institute-forms-analytics-subsidiary">Florida Cancer Specialists & Research Institute Forms Analytics Subsidiary</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-staff">AJMC Staff</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/florida-cancer-specialists-research-institute-forms-analytics-subsidiary"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/review-neoadjuvant-dual-icis-offer-better-response-than-anti-pd1-monotherapy-in-high-risk-resectable-melanoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f6cf7889450462cc5710d99d55c5f5a76e40fcf7-1600x900.webp?fit=crop&auto=format" alt="Opdivo and Yervoy | Image credit: Bristol Myers Squibb" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/review-neoadjuvant-dual-icis-offer-better-response-than-anti-pd1-monotherapy-in-high-risk-resectable-melanoma">Review: Neoadjuvant Dual ICIs Offer Better Response Than Anti-PD1 Monotherapy in High-Risk Resectable Melanoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/review-neoadjuvant-dual-icis-offer-better-response-than-anti-pd1-monotherapy-in-high-risk-resectable-melanoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">An alternative dose of ipilimumab and nivolumab had less toxicity than a conventional dose, the results show.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/immuno-oncology?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/immuno-oncology?page=2">2</a><a class="px-4 py-2 border-y border-r " 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The overall survival improved with a hazard ratio of 0.78. The median survival improved to 21.7 months with cisplatin-gemcitabine plus nivolumab, and the control arm—cisplatin-gemcitabine alone—was 18.9 months. The progression-free survival also improved, with a hazard ratio that was even better: 0.72.","_key":"87c1baf8be2a0","_type":"span"}],"_type":"block"},{"_key":"b64da61c162b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"45d7a73ff5c5"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"At the median time point, you don't actually see an improvement with around 7.6 and 7.9 months. But the unique thing about the progression-free survival was that there was separation of the curve for these 2 arms at around the 6-month time point, so that at the 2-year time point and even the 1-year time point, there was significant separation. 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That was the most unique part of this really durable benefit in a subgroup of patients that had complete remission, which was 22% of patients, approximately.","_key":"e2fe2850d6b3","_type":"span"}],"_type":"block","style":"normal","_key":"27cdac8cd909"},{"children":[{"text":"","_key":"da6353803564","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"5d538b823b2d","markDefs":[]},{"_key":"5ed9cc404b33","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you discuss the implications of these findings and directions for future research?","_key":"6fd275092f190"}],"_type":"block","style":"normal"},{"_key":"80973ded9e7a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"This combination was active and improved overall survival and progression-free survival, and the highlight was the complete remission rate of 22%, which was highly durable, with a median duration of complete response of 37 months. Now, one of the unique things I will point out is that the toxicity profile was very, very manageable and was consistent with what we see with cisplatin-gemcitabine and with nivolumab—so no excessive toxicity over what we see with these 2 regimens was seen. ","_key":"80ee887941890"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4431362362c6"}],"_type":"block","style":"normal","_key":"1f23becaf89c"},{"style":"normal","_key":"ea0142cefa36","markDefs":[],"children":[{"_key":"ce52bd3b8983","_type":"span","marks":[],"text":"One of the key aspects of this trial is that the chemotherapy component stopped at a maximum of 6 cycles, and thereafter, it was only nivolumab that continued after the gem-cis-nivo combination was completed for a total of up to 6 cycles. That really helps the patients because they don't accumulate toxicities of the cytotoxic regimen, because you're giving a finite duration of the chemotherapy for up to 6 cycles and then stopping chemotherapy. "}],"_type":"block"},{"markDefs":[],"children":[{"text":"","_key":"85c0765f8416","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"32661e3bad62"},{"markDefs":[],"children":[{"marks":[],"text":"I do bring up and contrast it with the other regimen that has been developed and has been in the news based on a positive phase 3 trial, which was the combination of EV—enfortumab vedotin—an antibody-drug conjugate, plus pembrolizumab, which also improved overall survival and progression-free survival. But in that case, the regimen is continued until progression or toxicity, which suggests that many patients might accumulate some of the toxicities if you continue the treatment until toxicities. 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Now, when it was first developed, the principal application for it was in the metastatic setting, so people who had disease that had spread to other locations. As they started to do studies using immunotherapy, either as a single agent, so on its own, or combining it with chemotherapies, we're starting to see outcomes coming out in these metastatic trials showing that patients are having an improved or enhanced progression-free survival, so meaning their cancer is either responding and shrinking, or it's keeping them at the same place and sort of avoiding that progression or spread to new and other locations.","_key":"c5b744356dcb0","_type":"span"}],"_type":"block","style":"normal","_key":"2287f373c917"},{"children":[{"marks":[],"text":"","_key":"834d64d1c4c10","_type":"span"}],"_type":"block","style":"normal","_key":"9d7ad51474a2","markDefs":[]},{"style":"normal","_key":"c826cd747019","markDefs":[],"children":[{"_type":"span","marks":[],"text":"With that in mind, and seeing some of those benefits in the later stages, with all of us really wanting the outcomes to be phenomenal in the early stage, none of us want to stop until we're having greater than 90% for all of our stages at 5 years, we start to see some of those therapies trickle into the earlier stage.","_key":"19ef33211f710"}],"_type":"block"},{"_key":"1b5e39543247","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3ab2f3c708890"}],"_type":"block","style":"normal"},{"children":[{"marks":[],"text":"The first trial that was approved to move immunotherapy into an earlier stage of lung cancer was the ","_key":"1701df7edee30","_type":"span"},{"_type":"span","marks":["6ebd68aa3071"],"text":"IMpower010","_key":"02832112cbff"},{"_key":"5bafae1edd03","_type":"span","marks":[],"text":" trial. What that trial did is it randomized patients who had completely resected lung cancer. They included stages 1B all the way through 3A. A lot of the analyses were done specifically on that 2 and 3A population."}],"_type":"block","style":"normal","_key":"74c51120176b","markDefs":[{"_key":"6ebd68aa3071","nofollow":true,"blank":true,"_type":"link","href":"https://classic.clinicaltrials.gov/ct2/show/NCT02486718"}]},{"markDefs":[],"children":[{"_key":"af195b2ca8e80","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"223688f8c946"},{"style":"normal","_key":"8d9e639a6059","markDefs":[],"children":[{"_type":"span","marks":[],"text":"After the complete resection, they underwent the standard of care chemotherapy, and then they were randomized to either immunotherapy or best supportive care. When we look at the disease-free survival, so we're using a lot of surrogate end points to try and help us understand the efficacy of these therapies with the idea that we want to try to get them to market to our patients faster, disease-free survival statistically significantly better in the immunotherapy arm for patients who are PD-L1 positive in that kind of 2 and 3A arm.","_key":"d800207fe1e60"}],"_type":"block"},{"children":[{"marks":[],"text":"","_key":"d4d81a2094c30","_type":"span"}],"_type":"block","style":"normal","_key":"840dbbc8fcaa","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"Now, we're starting to get some of the data for the overall survival, and those curves are narrowing just a little bit. Our overall survival isn't significant for that entire population, but when we start to glance at some of the subset analyses, there's some signals that we're seeing. So, perhaps the more advanced stages, so stage 3A and those that are PD-L1 high, so greater than 50%, that kind of median survival still hasn't reached. We have a beautiful separation of the curves, our hazard ratio right now looks like it's going to be statistically significant, but we still don't have quite enough data to make all the conclusions on that.","_key":"a39a1bfd34f30"}],"_type":"block","style":"normal","_key":"fd343f2b9b37","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"3f89f0fe11a50"}],"_type":"block","style":"normal","_key":"fb061131fc28","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Based on some of the progression-free survival data, we do see that is an approved regimen, so it is FDA approved, we are seeing it being applied to patients. I think we're still going to need to hone in just a little bit for whom it's going to have the most benefit. All of us are suspecting it's going to be those slightly higher stages, higher PD-L1, but there's no doubt that this is providing a survival benefit to some of our patients in the earlier setting.","_key":"f25cfe5f877e0"}],"_type":"block","style":"normal","_key":"c0ddc8f386be"},{"style":"normal","_key":"ffa13c456628","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"936dc6c80bed0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"Within the neoadjuvant space, we have a lot of excitement as well. ","_key":"e46cd5a361e90"},{"_type":"span","marks":["2a45f0467754"],"text":"CheckMate 816","_key":"efa0c2e97868"},{"_type":"span","marks":[],"text":" is really the first of its kind in the neoadjuvant setting using chemo-IO combination prior to surgery. 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They were able to show that we're having a high rate of completion of safe surgery, no increased morbidity, no significantly increased time.","_key":"96582329efe00","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"6bd51abfb7b5","markDefs":[]},{"_key":"26af4e35d9df","markDefs":[],"children":[{"_key":"c610138e38210","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"_key":"e2a6dadd469a","markDefs":[],"children":[{"text":"We see some trends towards a higher number of cases being able to be performed minimally invasively, higher number of cases of a lesser resection, so more lobectomy, more sleeve resections, fewer pneumonectomies. A lot more data needs to be collected in this space, but really, really, really exciting start.","_key":"e5159d181df20","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"4e89c3bb0491","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0dae3b00582d0"}]},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://classic.clinicaltrials.gov/ct2/show/NCT03425643","_key":"0204ccb124b6"},{"blank":true,"_type":"link","href":"https://classic.clinicaltrials.gov/ct2/show/NCT03800134","_key":"08f3874eb642","nofollow":true}],"children":[{"text":"Now, what do we do in the adjuvant space when we think about something like Checkmate 816? They didn't have a dedicated adjuvant regimen. It was left up to really the discretion of the treating physician who's taking care of this patient. 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Among the top issues are inappropriate care and wasteful health care spend.","_key":"5bb774ae88b4","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"text":"Transcript","_key":"47da29800ec0","_type":"span","marks":["strong","underline"]}],"_type":"block","style":"normal","_key":"4deec6f00023","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you discuss potential policy priorities to increase equitable access to health care?","_key":"89bcd40ae2910"}],"_type":"block","style":"normal","_key":"87b54bd392dd"},{"markDefs":[],"children":[{"text":"Curing cancer is, of course, the headline—that's what we're all wanting to do. But where we sort of ail and have an issue with is the logistics of how do you translate that. Precision medicine certainly plays a huge role in that, and health equity plays a huge role in that because access to care is one big problem that we have in this country. Another big problem, which I think is equally large, is that we have a lot of waste within our system. I would say probably a good third of our health care dollar is stuck in our system because we duplicate care, or we have care that is inappropriate, too late or early, wrong, whatever. 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Or conversely, for patients who are seen in higher-level centers of care where the physicians are familiar with the precision medicine approach and have the ","_key":"eec480a7549d0"},{"_key":"64f4410ca753","_type":"span","marks":["de525ab7c36d"],"text":"logistical background that I discussed earlier"},{"_type":"span","marks":[],"text":", where you have all the pieces in place where such tests can actually lead to an impact on their care.","_key":"40e75cb45be5"}],"_type":"block","style":"normal","_key":"b3729f5a3af2"},{"children":[{"_key":"c6f7e9a9ac220","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"b9eba9417561","markDefs":[]},{"children":[{"_key":"8bec3624c1e10","_type":"span","marks":[],"text":"And so what I think would probably be the very best sort of societal approach to equity in care would be that we need to find a way to reflex these type of things. 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Choe is a head and neck oncologist at Vanderbilt University Medical Center and was a presenter at "},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"73cd49c8c0b61"},{"marks":["superscript"],"text":"®","_key":"73cd49c8c0b62","_type":"span"},{"_type":"span","marks":[],"text":"’s Institute for Value-Based Medicine","_key":"fca8e800b318"},{"_type":"span","marks":["superscript"],"text":"®","_key":"a1d798d31192"},{"text":" held in Nashville, Tennessee on August 17, 2023.","_key":"d90b905bcfca","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"3962e9e6d900","markDefs":[]},{"_type":"block","style":"normal","_key":"822bc8961b59","markDefs":[],"children":[{"text":"","_key":"eeb600acf9070","_type":"span","marks":[]}]},{"style":"normal","_key":"427b0291c715","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"d036d0eba1df0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"b11f807d4d820"}],"_type":"block","style":"normal","_key":"f75cceda4c23","markDefs":[]},{"markDefs":[],"children":[{"text":"Can you explain some of the thought behind why there is disease relapse in head and neck cancers after radiation treatment?","_key":"6ace196a983a0","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"59bfe871ba82"},{"style":"normal","_key":"ee0671ba6fa5","markDefs":[],"children":[{"_key":"a02988d5e86e0","_type":"span","marks":[],"text":""}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"There's a lot of theoretical basis as to why we think this is the case. A lot is driven by just aggressive biology; it's really not known. Head and neck cancers are considered immune responsive, technically speaking, but the response rates still are pretty low, in general, and whether or not the immune system and head and neck cancer patients are depressed compared to other cancers. I, in theory, think that a part of it is actually the radiation creating an environment where there could be a reduction in the body's ability to regulate the immune system.","_key":"57e65b7afadd0"}],"_type":"block","style":"normal","_key":"3933298175e8"},{"children":[{"_type":"span","marks":[],"text":"","_key":"cd6a01abb5ca0"}],"_type":"block","style":"normal","_key":"5d4af7ee84b8","markDefs":[]},{"_type":"block","style":"normal","_key":"9dba53743a26","markDefs":[],"children":[{"_type":"span","marks":[],"text":"There's an immune suppressed state for these patients that could be due to radiation of the lymph nodes that's decreasing the ability for the immune system to respond, but also the local radiation induced immune suppression effects that may be producing a more conducive environment for the cancer to return.","_key":"d392e3b637b30"}]},{"_key":"5f5f621264c2","markDefs":[],"children":[{"text":"","_key":"61119e04b5f60","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"ba5959aec606","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are some of the trials evaluating new treatment regimens for patients with head and neck cancers?","_key":"10b07fbb8ca50"}]},{"style":"normal","_key":"38c0595790d6","markDefs":[],"children":[{"marks":[],"text":"","_key":"a2b63914a6150","_type":"span"}],"_type":"block"},{"style":"normal","_key":"1e4c504729b6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The 2 big trials that actually did not meet their primary endpoints were 2 chemoradiation trials in the phase 3 stage. They're combining chemoradiation with immune checkpoint inhibitors concurrently given. We think that this likely could be due to a sequencing issue where they're actually creating an environment where they've ablated the immune prime cells with the chemoradiation given at the same time as the immune checkpoint inhibitor.","_key":"1307759d7f010"}],"_type":"block"},{"_key":"8cd9340937cf","markDefs":[],"children":[{"_key":"706d9d4571480","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Currently, there is actually an ongoing clinical trial with Invoke, which is basically looking at chemoradiation sequentially giving the immunotherapy after chemoradiation as opposed to combined with it. There are other combination therapies of looking at various components where they’re looking at whether or not they can make the radiation more effective, such as XIP [xylanase inhibitor protein] inhibitors to treat in combination with chemoradiation.","_key":"c69afe47a7690"}],"_type":"block","style":"normal","_key":"ef1b0bdd312b"},{"children":[{"_type":"span","marks":[],"text":"","_key":"d05fda1899390"}],"_type":"block","style":"normal","_key":"1be1cc9a2588","markDefs":[]},{"_key":"b7a84684ef90","markDefs":[],"children":[{"_key":"fb63d06c3f5b0","_type":"span","marks":[],"text":"There are a number of other clinical trials but they're more in the recurrent metastatic site, looking at some promising molecules. There are a few eGFR [epidermal growth factor receptor]-based antibodies that have come out, kind of leveraging what we already know about eGFR antibodies cetuximab and panitumumab but trying to actually improve upon that with these novel eGFR antibodies."}],"_type":"block","style":"normal"},{"_key":"b03ccd45e750","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8eb538f8dfd70"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":["strong"],"text":"What are some promising responses that you've seen so far?","_key":"f1c30acd250e0"}],"_type":"block","style":"normal","_key":"6ea62ddee83c","markDefs":[]},{"_type":"block","style":"normal","_key":"2e27be2a73ac","markDefs":[],"children":[{"text":"","_key":"9cfb1c10fe290","_type":"span","marks":[]}]},{"style":"normal","_key":"9108995d8722","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Where we've seen actually the most promise is actually these eGFR bispecific antibodies. Particularly, BCA-101 is one that has actually really created a lot of buzz at ASCO this year. Mainly in HPV [human papillomavirus] negative cancers, this is in the recurrent metastatic state, but there's actually been a few eGFR-based therapies that have come through, which has had very promising results. Ficlatuzumab has had some encouraging data, as well, which basically works based off of the eGFR resistance mechanism to try to induce response.","_key":"1632870a1b1d0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"05a3875c78de0"}],"_type":"block","style":"normal","_key":"bedec942bdc7","markDefs":[]},{"_type":"block","style":"normal","_key":"6b80a85f207c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We're seeing some evidence of some promising agents that are coming through using targeting of what we already knew, which is eGFR overexpression in head and neck cancers, in trying to improve upon what we already have is kind of our traditional cetuximab-based regimens. Hopefully, we can actually make some headway with those in promising clinical trials, not just in a recurrent metastatic setting but possibly pushing it up into the locally advanced setting.","_key":"6da437583ccb0"}]}],"summary":"Jennifer Choe, MD, PhD, a head and neck medical oncologist at Vanderbilt University Medical Center, discussed head and neck cancer relapse post-radiation therapy, new treatment trials, and any promising responses from them.","thumbnail":{"asset":{"extension":"png","mimeType":"image/png","sha1hash":"cf5b0621e771592b6215808be037020df8381a78","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/cf5b0621e771592b6215808be037020df8381a78-1823x1141.png","_createdAt":"2023-08-30T19:45:31Z","_updatedAt":"2023-08-30T19:45:31Z","_id":"image-cf5b0621e771592b6215808be037020df8381a78-1823x1141-png","size":1108594,"originalFilename":"Screen Shot 2023-08-30 at 3.15.31 PM.png","metadata":{"lqip":"data:image/png;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":1823,"aspectRatio":1.5977212971078,"height":1141},"isOpaque":true,"blurHash":"VUF$Y6V[_NozRO_3R*ofWVRjtRRjjERjt7%MfkWVWBj]","_type":"sanity.imageMetadata","palette":{"_type":"sanity.imagePalette","darkMuted":{"title":"#fff","population":0.02,"background":"#42544a","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"muted":{"population":0.01,"background":"#7a8c88","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff"},"lightVibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":0,"background":"#d4baa4"},"darkVibrant":{"title":"#fff","population":10.15,"background":"#5c2c17","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightMuted":{"population":9.77,"background":"#acb2b2","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff"},"vibrant":{"_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":2.47,"background":"#7d583a"},"dominant":{"foreground":"#fff","title":"#fff","population":10.15,"background":"#5c2c17","_type":"sanity.imagePaletteSwatch"}},"hasAlpha":true},"uploadId":"KIwNZsTBX90t3MSqJZfOBlmftPXaoFlP","_rev":"GURbY9Z1Ldkf59Am4H7BFa","_type":"sanity.imageAsset","path":"images/0vv8moc6/ajmc/cf5b0621e771592b6215808be037020df8381a78-1823x1141.png","assetId":"cf5b0621e771592b6215808be037020df8381a78"}},"ExcludeFromPubMedXML":false,"documentGroupMapping":[{"_ref":"d247ced1-b6ed-42bf-aeeb-b229ac676f67","_type":"reference","_key":"a83028df059c"}],"articleType":"News","contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"seoTag":["Jennifer Choe","IVBM","head and neck cancer","treatment trials","promising responses"],"authorMapping":[{"firstName":"Brooke","lastName":"McCormick","displayName":"Brooke McCormick","_rev":"A9UM2QVfJg2GpKiBNGLBGh","_id":"00af9d05-a2c4-4451-a6d1-0e28b08cbb65","biography":[{"children":[{"_type":"span","marks":[],"text":"Brooke is an associate editor for ","_key":"8d68730a8da0"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"730c46c984c9"},{"_type":"span","marks":[],"text":"® (","_key":"0b218fbaa571"},{"_key":"b1b5b3d9cff0","_type":"span","marks":["em"],"text":"AJMC"},{"text":"®). 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","_key":"10de258d8bce0"}]},{"style":"normal","_key":"8d5379a8674d","markDefs":[],"children":[{"marks":[],"text":"","_key":"3d0fdc832f1e","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"615349473012","_type":"span","marks":["strong","underline"],"text":"Transcript"}],"_type":"block","style":"normal","_key":"7bc7b23fecb9"},{"_key":"d02f2b02c04e","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"In light of the manufacturing challenges sometimes seen with CAR T-cell therapies for MM, what considerations should be taken into account when selecting a therapy among CAR T, bispecifics, or other options? ","_key":"0b4eac21d09c"}],"_type":"block","style":"normal"},{"style":"normal","_key":"084cc0d4fc0b","markDefs":[],"children":[{"_key":"8849c9b2981a0","_type":"span","marks":[],"text":"There's no doubt that there is still an access challenge, [and] that access challenge is multi-fold. Some of it has to do with manufacturing, some of it has to do with geography. And, sadly, a lot of it has to do with race and ethnicity, and socioeconomic status, as we've seen, tragically, that there are many individuals who simply do not have access to some of these novel therapies, namely CAR T-cell therapy and bispecifics. "}],"_type":"block"},{"markDefs":[],"children":[{"_key":"097c4439bb42","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"c7171f54343a"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think a lot of these challenges are being addressed head on—we are seeing greater manufacturing opportunities and more sites opening, we are recognizing, I think, a reality of the disparity that there is in access and how we can look at overcoming it. But all the while, whenever there is reduced access to any phenomenon in medicine, and particularly in cancer care, we want to make sure that the the right patient is being treated with the right therapy at the right time. And part of the challenge is that we really don't know the right sequence yet. Is it better to do it bispecific than a CAR T or vice versa? And so right now, very often, it's whatever is available. The best one available, obviously, is the best one to use because it is the only one available. But I do see that this is a challenge right now, especially across the diversity of the United States and really the world. But I do think that we are trying to more strategically address the issue so that we can have choice, because there are some patients that are simply not going to be eligible for a CAR T-cell therapy who may be eligible for biospecifics—and, frankly, vice versa. ","_key":"3e38a2d163d7"}],"_type":"block","style":"normal","_key":"f78238d70b9a"},{"children":[{"_type":"span","marks":[],"text":"","_key":"431de21e0bff"}],"_type":"block","style":"normal","_key":"f790a490179b","markDefs":[]},{"children":[{"_key":"7e0713d9301d","_type":"span","marks":[],"text":"The beauty of these different treatments is that they have different approaches to therapy. Some require more hospitalization or less hospitalization, or can be given in older, more frail patients [that] others may not be. Ultimately, we want to be able to match the right treatment to the right patient. And in the interim, we're trying to prioritize in a way that recognizes the severity of one's disease, but also recognizes that we want to optimize the efficacy of these agents."}],"_type":"block","style":"normal","_key":"7a603f54333e","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"38f55b1c1063"}],"_type":"block","style":"normal","_key":"b4c4d35f9f41","markDefs":[]},{"markDefs":[],"children":[{"_key":"d8a1b76076c50","_type":"span","marks":["strong"],"text":"Are there any alternative strategies being explored to improve the manufacturing process and accessibility of CAR T-cell therapies for MM? "}],"_type":"block","style":"normal","_key":"55958479452b"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Everything is on the table with increasing access to CAR T-cell therapy. I think there is a move from the manufacturers themselves, from the academic centers, from the community, from regulatory agencies. I mean, I think everyone recognizes that this is a therapy that can have a tremendous impact, but it's not going to have an impact if people don't have access to it. ","_key":"6a935ab922150"}],"_type":"block","style":"normal","_key":"4b6ad44c802a"},{"_key":"e4d07c81eb8e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f102b72d59c1"}],"_type":"block","style":"normal"},{"_key":"f4c9e583465e","markDefs":[],"children":[{"marks":[],"text":"I think we're also realistic that this is not a problem that can just easily be solved overnight. This is a complex treatment that requires highly sophisticated centers that can collect T cells, that can then manufacture those T cells, [and] that can then reinfuse them. I'm by no means admitting that there should be such a disparity, but at the same time, I think we have to recognize that if we want to do it, we need to do it correctly. 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Kunz, MS, LCGC, senior genetic counselor at the US Oncology Network, discussed the importance of germline genetic testing in patients with triple-negative breast cancer and other cancer types. ","_key":"b53f0e02425b0"}],"_type":"block","style":"normal","_key":"e4d49d245172"},{"markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/conference/asco","_key":"f391b45e8bd4","nofollow":true}],"children":[{"_key":"fcce654f1087","_type":"span","marks":[],"text":"In a study presented at the "},{"_type":"span","marks":["f391b45e8bd4"],"text":"2023 American Society of Clinical Oncology Annual Meeting","_key":"e39ee565a2b4"},{"marks":[],"text":", Kunz and colleagues found that social determinants of health, particularly related to race and the type of insurance coverage patients had, impacted genetic testing rates in the community oncology setting.","_key":"4f91ba60e337","_type":"span"}],"_type":"block","style":"normal","_key":"f3734c67e85d"},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"28f31e7b3781"}],"_type":"block","style":"normal","_key":"94eb17db8880"},{"style":"normal","_key":"51fedd270458","markDefs":[],"children":[{"marks":["strong"],"text":"What are the implications of these findings for patients with TNBC and other cancer types where germline testing is recommended?","_key":"1433a39810fc0","_type":"span"}],"_type":"block"},{"_type":"block","style":"normal","_key":"d53428b9776a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think the biggest implication is trying to understand why these differences exist, and how can we address them? 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Socinski, MD, executive director of the AdventHealth Cancer Institute, shared his thoughts on the most important recent advances in non–small cell lung cancer (NSCLC), including a better understanding of patients who may benefit from immunotherapy.","_key":"d854fb1ccd6a"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"1fadd28406ad","_type":"span"}],"_type":"block","style":"normal","_key":"6f192e4f2003"},{"style":"normal","_key":"e3647972f519","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript ","_key":"4d75292cb698"}],"_type":"block"},{"style":"normal","_key":"5f539ddb95f7","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are some notable recent advancements in the NSCLC treatment landscape?","_key":"06c5f1bba64d0"}],"_type":"block"},{"_key":"f24b0350b27e","markDefs":[],"children":[{"text":"I think the most important recent advances have been the continuation of understanding that non–small cell lung cancer is a group of very heterogeneous patients and diseases and that certainly, we've transitioned from 20 or 30 years ago, [when it was] kind of one-size-fits-all, to realizing that there are a number of biomarker findings that are important in deciding which treatment approach is best for the individual patient that that's in front of you. 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In addition to the targeted agents that are there, we have validated the PD-1 and PD-L1 pathway, we've also validated the CTLA-4 pathway as a target of anti-cancer therapy."}],"_type":"block","style":"normal","_key":"5b198c38d0e1"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f8533932f39c0"}],"_type":"block","style":"normal","_key":"35b901302c3f"},{"_type":"block","style":"normal","_key":"99c2652b4afb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the targeted therapy space, I think we're on the verge of understanding patterns of resistance. We have some pretty good drugs to use in the first line, but the issue there is that most patients develop resistance. 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Hundreds of patients have either recently or are currently being treated using CRISPR.","_key":"b2f0922949dd0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"902079af6d8b","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"67162807f8d00"}],"_type":"block","style":"normal","_key":"a0a044e4041a"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"CRISPR was developed around 2012 to 2013 in some landmark articles, most of them published in the journal ","_key":"d9aa607b180f0"},{"marks":["em"],"text":"Science","_key":"d9aa607b180f1","_type":"span"},{"_type":"span","marks":[],"text":", and from that time, scientists have built a toolbox that allows them to edit the DNA of all organisms—but of course, we're mostly interested in humans—and to tackle a growing list of diseases as well as use CRISPR in the context of CAR T [chimeric antigen receptor T-cell] therapies for various types of leukemia and other cancers. 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","_key":"f91a6ebca983"}]},{"markDefs":[],"children":[{"text":"","_key":"b1549d70fe7c","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"455f6003304d"},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"f0b3d6648f0e"}],"_type":"block","style":"normal","_key":"51c7542b8abd"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are the benefits of collecting data on social determinants of health versus the anticipated benefits for patients of collecting their data?","_key":"728b9ce164f20"}],"_type":"block","style":"normal","_key":"12155589e89a"},{"_type":"block","style":"normal","_key":"dba93e33df67","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Yeah, so there's a lot of talk about that, I think the practices really understand that some of that health data is important. And it really impacts the outcomes that the patients will have as far as their treatment goes. But the practices don't really know how to go about doing that. ","_key":"703b3fa289ab0"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"And what that communication is going to look like with the patient, it's really hard to garner that kind of trust with the patients, and then explain to the patients, what's going to be done with that data after we get this information from you, and make them feel secure that that data is going to be managed in a secure manner. And that they might, they just might not want to share that information. ","_key":"c355cf4a7380"}],"_type":"block","style":"normal","_key":"468beadade6a"},{"markDefs":[],"children":[{"marks":[],"text":"And so there's a trusting relationship between the practice, the physicians, the nurses, and all of the people that work in the practice that take care of the patient. And if the patients think that they're giving this information, and you're going to turn it over to someone else, that kind of breaks down that trust a little bit. So I think there's a lot of kind of angst about what that's going to look like and how that's going to come to fruition. And what's going to happen with all that data.","_key":"d4c997a39246","_type":"span"}],"_type":"block","style":"normal","_key":"b5421aec97c5"},{"markDefs":[],"children":[{"text":"","_key":"6aeb7036a0a80","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"43b2107ae0e1"},{"style":"normal","_key":"856199e88525","markDefs":[],"children":[{"_key":"efca998beab4","_type":"span","marks":["strong"],"text":"When it comes to collecting SDOH [social determinants of health] data, can you discuss the balance between the burden of data collection on oncology practices vs the compensation the practices will receive?"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"Yeah, that's a great question. You know, the practices are already running very lean, they're still struggling with staffing, resources and issues, you know, from COVID. 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