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href="https://www.academia.edu/121716252/Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation"><img alt="Research paper thumbnail of Potential therapy of Fc-antigen combination-encoding DNA vaccination in mouse allergic airway inflammation" class="work-thumbnail" src="https://attachments.academia-assets.com/116531029/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121716252/Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation">Potential therapy of Fc-antigen combination-encoding DNA vaccination in mouse allergic airway inflammation</a></div><div class="wp-workCard_item"><span>Clinical & Experimental Immunology</span><span>, 2008</span></div><div class="wp-workCard_item 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vaccination in mouse allergic airway inflammation","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"Vaccination with allergen-encoding DNA has been proposed as having potential for allergen-specific immunotherapy. In this study, we examine the therapeutic effect of allergen-encoding DNA vaccination directly to dendritic cells (DCs) on allergen-induced allergic airway inflammation in a mouse model and explore potential mechanism. Ovalbumin (OVA)-sensitized and challenged mice were immunized with DNA vaccine and received bronchoalveolar lavage (BAL) 1 day after the last challenge, to measure BAL levels of interleukin (IL)-4, IL-5, interferon (IFN)-gamma and differential cell count. Pulmonary DCs and Spleen DCs were purified and sorted according to the expression of CD11c + CD80 + and CD11c + CD86 + co-stimulatory molecules. Our data demonstrated that DNA vaccine therapy with OVA-Fc-pcDNA3•1 significantly prevented OVA-increased levels of IL-4, IL-5 and the percentage of eosinophils and OVA-decreased level of IFN-gamma. OVA-Fc-pcDNA3•1treated mice had less severity of airway inflammation, and lower expression of CD11c + CD80 + and CD11c + CD86 + on pulmonary DCs, as compared with animals with OVA-pcDNA3•1, pcDNA3•1 and OVA respectively. DNA vaccine encoding both Fc and OVA was shown to be more effective than DNA vaccine encoding OVA alone. Our data indicate that Fc-antigen combinationencoding DNA vaccination has better preventive effects on antigen-induced airway inflammation by regulating DCs, and may be a new alternative therapy for asthma.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Clinical \u0026 Experimental Immunology","grobid_abstract_attachment_id":116531029},"translated_abstract":null,"internal_url":"https://www.academia.edu/121716252/Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation","translated_internal_url":"","created_at":"2024-07-02T06:16:21.183-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":116531029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116531029/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116531029/download_file?st=MTczMjczODQyMCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Potential_therapy_of_Fc_antigen_combinat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116531029/pdf-libre.pdf?1719926409=\u0026response-content-disposition=attachment%3B+filename%3DPotential_therapy_of_Fc_antigen_combinat.pdf\u0026Expires=1732742020\u0026Signature=V4RR8iou2eGBAeivpjLuV1jqN4RCtsasHQ-L5R39xu~0qmdm53JrVJO7SJdADZxKWVxoSesDOz~XVMY4FNOx5F9yDwwl~vpiYjM50-0RTK~a58tdeH~io2M4cbAMnuh1tZcle2nPrLFhyfgvQW2QEKs7-DQtLERDAoo-uaAnWbEf3K-oYcM~NycGvQJFDY7tpn7PC5RlwWmcUMLXAcjz8etTv17S9eghgQmf8fOt66shoLOI6iAHLIyVTOzhvcN51Aw9cOvnqcu4oFYtGGWqKPjaI6B~oaURFCe3jehj3shbVvbHbJyO5B8R1xi4sqopbfjKfQAio4cxl90HE0bEHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":116531029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116531029/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116531029/download_file?st=MTczMjczODQyMCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Potential_therapy_of_Fc_antigen_combinat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116531029/pdf-libre.pdf?1719926409=\u0026response-content-disposition=attachment%3B+filename%3DPotential_therapy_of_Fc_antigen_combinat.pdf\u0026Expires=1732742020\u0026Signature=V4RR8iou2eGBAeivpjLuV1jqN4RCtsasHQ-L5R39xu~0qmdm53JrVJO7SJdADZxKWVxoSesDOz~XVMY4FNOx5F9yDwwl~vpiYjM50-0RTK~a58tdeH~io2M4cbAMnuh1tZcle2nPrLFhyfgvQW2QEKs7-DQtLERDAoo-uaAnWbEf3K-oYcM~NycGvQJFDY7tpn7PC5RlwWmcUMLXAcjz8etTv17S9eghgQmf8fOt66shoLOI6iAHLIyVTOzhvcN51Aw9cOvnqcu4oFYtGGWqKPjaI6B~oaURFCe3jehj3shbVvbHbJyO5B8R1xi4sqopbfjKfQAio4cxl90HE0bEHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":166422,"name":"DNA vaccines","url":"https://www.academia.edu/Documents/in/DNA_vaccines"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":207341,"name":"DNA vaccination","url":"https://www.academia.edu/Documents/in/DNA_vaccination"},{"id":371516,"name":"Eosinophils","url":"https://www.academia.edu/Documents/in/Eosinophils"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"},{"id":3508723,"name":"Ovalbumin ","url":"https://www.academia.edu/Documents/in/Ovalbumin"},{"id":4075992,"name":"Immunoglobulin Fc Fragments","url":"https://www.academia.edu/Documents/in/Immunoglobulin_Fc_Fragments"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458023"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458023/Lung_Defense_through_Interleukin_8_Carries_a_Cost_of_Chronic_Lung_Remodeling_and_Impaired_Function"><img alt="Research paper thumbnail of Lung Defense through Interleukin-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function" class="work-thumbnail" src="https://attachments.academia-assets.com/71318140/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458023/Lung_Defense_through_Interleukin_8_Carries_a_Cost_of_Chronic_Lung_Remodeling_and_Impaired_Function">Lung Defense through Interleukin-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function</a></div><div class="wp-workCard_item"><span>American journal of respiratory cell and molecular biology</span><span>, Jan 12, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, ye...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases including COPD, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible pathologic, changes associated with elevated levels of IL-8 in the lung. To better understand the duality of IL-8 dependent host immunity to bacterial infection and lung pathology, we targeted human IL-8 to express transgenically in murine bronchial epithelium, investigating the impact of over-expression on lung bacterial clearance, host immunity, lung pathology and function. Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation, activation and chemtoaxis. There was enhanced protection from challenge with Pseudomonas aeruginosa and significant changes in baseline expression of innate and adaptive immunity transcripts for Ccl5, Tlr6, IL2 and Tlr1. There was increased expression of Tbet and Foxp3 in response to the Pseudomona...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d7832bbb5b3c2cfa2ad34848434f354" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318140,"asset_id":55458023,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318140/download_file?st=MTczMjczODQyMCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458023"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458023"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458023; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458023]").text(description); $(".js-view-count[data-work-id=55458023]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458023; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458023']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458023, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d7832bbb5b3c2cfa2ad34848434f354" } } $('.js-work-strip[data-work-id=55458023]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458023,"title":"Lung Defense through Interleukin-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function","translated_title":"","metadata":{"abstract":"IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases including COPD, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible pathologic, changes associated with elevated levels of IL-8 in the lung. To better understand the duality of IL-8 dependent host immunity to bacterial infection and lung pathology, we targeted human IL-8 to express transgenically in murine bronchial epithelium, investigating the impact of over-expression on lung bacterial clearance, host immunity, lung pathology and function. Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation, activation and chemtoaxis. There was enhanced protection from challenge with Pseudomonas aeruginosa and significant changes in baseline expression of innate and adaptive immunity transcripts for Ccl5, Tlr6, IL2 and Tlr1. There was increased expression of Tbet and Foxp3 in response to the Pseudomona...","publication_date":{"day":12,"month":1,"year":2018,"errors":{}},"publication_name":"American journal of respiratory cell and molecular biology"},"translated_abstract":"IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases including COPD, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible pathologic, changes associated with elevated levels of IL-8 in the lung. To better understand the duality of IL-8 dependent host immunity to bacterial infection and lung pathology, we targeted human IL-8 to express transgenically in murine bronchial epithelium, investigating the impact of over-expression on lung bacterial clearance, host immunity, lung pathology and function. Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation, activation and chemtoaxis. There was enhanced protection from challenge with Pseudomonas aeruginosa and significant changes in baseline expression of innate and adaptive immunity transcripts for Ccl5, Tlr6, IL2 and Tlr1. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458020"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458020/Targeting_the_Wnt_regulatory_protein_CTNNBIP1_by_microRNA_214_enhances_the_stemness_and_self_renewal_of_cancer_stem_like_cells_in_lung_adenocarcinomas"><img alt="Research paper thumbnail of Targeting the Wnt-regulatory protein CTNNBIP1 by microRNA-214 enhances the stemness and self-renewal of cancer stem-like cells in lung adenocarcinomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458020/Targeting_the_Wnt_regulatory_protein_CTNNBIP1_by_microRNA_214_enhances_the_stemness_and_self_renewal_of_cancer_stem_like_cells_in_lung_adenocarcinomas">Targeting the Wnt-regulatory protein CTNNBIP1 by microRNA-214 enhances the stemness and self-renewal of cancer stem-like cells in lung adenocarcinomas</a></div><div class="wp-workCard_item"><span>Stem cells (Dayton, Ohio)</span><span>, Jan 24, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A novel hypothesis in cancer biology proposes that cancer growth is driven by cancer stem-like ce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A novel hypothesis in cancer biology proposes that cancer growth is driven by cancer stem-like cells (CSLCs), also called tumor-initiating cells, which can self-renew and differentiate into multi-lineage progeny in a fashion similar to stem cells. However, the impact and underlying mechanisms of this process in lung adenocarcinoma (LAC) remains to be elucidated. Here, we report that microRNA-214 (miR-214) contributes to cell self-renewal by directly targeting CTNNBIP1, a member of the Wnt signaling pathway. We demonstrate that miR-214 overexpression enhances stem-like properties in LAC cells and that miR-214 shows increased expression in CSLCs derived from primary tumor tissue and from two LAC cell lines (A549 and NCI-H1650). Strikingly, down-regulation of miR-214 expression in CSLCs resulted in a significant decrease in spheroid formation and the expression of the stem-cell markers Nanog, Oct-4, and Sox-2. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458017"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55458017/Idiopathic_airway_centered_interstitial_fibrosis_report_of_two_cases"><img alt="Research paper thumbnail of Idiopathic airway-centered interstitial fibrosis: report of two cases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55458017/Idiopathic_airway_centered_interstitial_fibrosis_report_of_two_cases">Idiopathic airway-centered interstitial fibrosis: report of two cases</a></div><div class="wp-workCard_item"><span>Chinese medical journal</span><span>, Jan 5, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458017"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458017"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458017; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458016"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55458016/_Airway_centered_interstitial_fibrosis_"><img alt="Research paper thumbnail of [Airway-centered interstitial fibrosis]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55458016/_Airway_centered_interstitial_fibrosis_">[Airway-centered interstitial fibrosis]</a></div><div class="wp-workCard_item"><span>Zhonghua bing li xue za zhi Chinese journal of pathology</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458016"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458016"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458016; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458014"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458014/Metformin_inhibits_the_IL_6_induced_epithelial_mesenchymal_transition_and_lung_adenocarcinoma_growth_and_metastasis"><img alt="Research paper thumbnail of Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis" class="work-thumbnail" src="https://attachments.academia-assets.com/71318134/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458014/Metformin_inhibits_the_IL_6_induced_epithelial_mesenchymal_transition_and_lung_adenocarcinoma_growth_and_metastasis">Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. However,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. However, the underlying mechanisms of EMT in lung adenocarcinoma, and how this process might be inhibited, remain to be explored. This study investigated the role of IL-6 in lung adenocarcinoma cell EMT and explored the potential effects of metformin on this process. Invasion assay and MTT assay was performed to determine cell invasion and cell proliferation. Western blotting, immunofluorescence, real-time PCR, ELISA, and immunohistochemistry were performed to detect the expression of IL-6, E-cadherin, Vimentin, and p-STAT3. We discovered that IL-6, via STAT3 phosphorylation, could promote lung adenocarcinoma cell invasion via EMT in vitro. This was supported by the inverse correlation between E-cadherin and IL-6 expression, positive correlation between IL-6 and vimentin mRNA expression and between STAT3 phosphorylation and IL-6 expression in tumor tissues. Importantly, metformin inhibited tumor...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ccc32f870f090f4d47652b9b6dce74f2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318134,"asset_id":55458014,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318134/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458014"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458014"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458014; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458014]").text(description); $(".js-view-count[data-work-id=55458014]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458014; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458014']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458014, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ccc32f870f090f4d47652b9b6dce74f2" } } $('.js-work-strip[data-work-id=55458014]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458014,"title":"Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis","translated_title":"","metadata":{"abstract":"Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. 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alt="Research paper thumbnail of Induction of TRAG-3 expression in A549 lung adenocarcinoma cell line by 5-aza-2′ deoxyazacytidine" class="work-thumbnail" src="https://attachments.academia-assets.com/71318141/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458013/Induction_of_TRAG_3_expression_in_A549_lung_adenocarcinoma_cell_line_by_5_aza_2_deoxyazacytidine">Induction of TRAG-3 expression in A549 lung adenocarcinoma cell line by 5-aza-2′ deoxyazacytidine</a></div><div class="wp-workCard_item"><span>Lung Cancer</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0dec8a9f936330b13f6b34ed490db553" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458012/Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma"><img alt="Research paper thumbnail of Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma" class="work-thumbnail" src="https://attachments.academia-assets.com/71318143/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458012/Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma">Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma</a></div><div class="wp-workCard_item"><span>Journal of Translational Medicine</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor cells but come into apoptosis in a certain period and the latter is static with the ability of self-renewal. Previous studies showed that microRNAs (miRNA) played critical roles in regulating adaptive immunity. This study aimed to identify the different expression of miRNAs between Te and Tm cells in tumor-bearing mice and to sort out the target miRNAs which can be regulated to improve anti-tumor activities of CD8+ T cells. Methods miRNA expression profiling was performed on CD8+ Te and Tm cells from mice with Lewis lung carcinoma. Differentially expressed miRNA (miRNA-15b) was chosen and analyzed by qRT-PCR. Then, flow cytometry, ELISA, and CFSE kit were used to evaluate the biological effects of miRNA-15b on apoptosis, cytokine secretion, phenotype, and proliferat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="67d41a4685dee50f5c6239c3715ab2b6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318143,"asset_id":55458012,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318143/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458012"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458012"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458012; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458012]").text(description); $(".js-view-count[data-work-id=55458012]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458012; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458012']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458012, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "67d41a4685dee50f5c6239c3715ab2b6" } } $('.js-work-strip[data-work-id=55458012]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458012,"title":"Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma","translated_title":"","metadata":{"abstract":"Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor cells but come into apoptosis in a certain period and the latter is static with the ability of self-renewal. Previous studies showed that microRNAs (miRNA) played critical roles in regulating adaptive immunity. This study aimed to identify the different expression of miRNAs between Te and Tm cells in tumor-bearing mice and to sort out the target miRNAs which can be regulated to improve anti-tumor activities of CD8+ T cells. Methods miRNA expression profiling was performed on CD8+ Te and Tm cells from mice with Lewis lung carcinoma. Differentially expressed miRNA (miRNA-15b) was chosen and analyzed by qRT-PCR. Then, flow cytometry, ELISA, and CFSE kit were used to evaluate the biological effects of miRNA-15b on apoptosis, cytokine secretion, phenotype, and proliferat...","publisher":"Springer Nature","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of Translational Medicine"},"translated_abstract":"Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor cells but come into apoptosis in a certain period and the latter is static with the ability of self-renewal. Previous studies showed that microRNAs (miRNA) played critical roles in regulating adaptive immunity. This study aimed to identify the different expression of miRNAs between Te and Tm cells in tumor-bearing mice and to sort out the target miRNAs which can be regulated to improve anti-tumor activities of CD8+ T cells. Methods miRNA expression profiling was performed on CD8+ Te and Tm cells from mice with Lewis lung carcinoma. Differentially expressed miRNA (miRNA-15b) was chosen and analyzed by qRT-PCR. Then, flow cytometry, ELISA, and CFSE kit were used to evaluate the biological effects of miRNA-15b on apoptosis, cytokine secretion, phenotype, and proliferat...","internal_url":"https://www.academia.edu/55458012/Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma","translated_internal_url":"","created_at":"2021-10-04T08:58:25.664-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71318143,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318143/thumbnails/1.jpg","file_name":"PMC3608092.pdf","download_url":"https://www.academia.edu/attachments/71318143/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamically_expressed_microRNA_15b_modul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318143/PMC3608092-libre.pdf?1633364843=\u0026response-content-disposition=attachment%3B+filename%3DDynamically_expressed_microRNA_15b_modul.pdf\u0026Expires=1732742021\u0026Signature=CT1yeXKVTfgXhcB4hASI18uQ6nZghXb0-VZajUwJEfOVY28sGjPihG-POmOJVI0WibQcSJ2EJTIZSvFL3W7ts1jaMu90W5JAGW-Ox3XUpo5BtQt2Xak~EB58ggTlIJhkFUdWp28tK-Zspdr7Wu8RZs6UKsPULEoJqZxd1mTGN6dEhOHseA8xE2krGX9Qo0zfWCRgJuy-MeZWP159~6lzYQGoFjG94wg0tL-NlR7T1wu07TaVJk4svP6jtGy7czBAEyfxn9gjlaTyUsOTHvYa0jQNl7TSaGRUXce0A-o~faOvwO3AaVhy0Fb7M42QAdTwv52KxqhuLR96V5Pt-gRAtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":71318143,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318143/thumbnails/1.jpg","file_name":"PMC3608092.pdf","download_url":"https://www.academia.edu/attachments/71318143/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamically_expressed_microRNA_15b_modul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318143/PMC3608092-libre.pdf?1633364843=\u0026response-content-disposition=attachment%3B+filename%3DDynamically_expressed_microRNA_15b_modul.pdf\u0026Expires=1732742021\u0026Signature=CT1yeXKVTfgXhcB4hASI18uQ6nZghXb0-VZajUwJEfOVY28sGjPihG-POmOJVI0WibQcSJ2EJTIZSvFL3W7ts1jaMu90W5JAGW-Ox3XUpo5BtQt2Xak~EB58ggTlIJhkFUdWp28tK-Zspdr7Wu8RZs6UKsPULEoJqZxd1mTGN6dEhOHseA8xE2krGX9Qo0zfWCRgJuy-MeZWP159~6lzYQGoFjG94wg0tL-NlR7T1wu07TaVJk4svP6jtGy7czBAEyfxn9gjlaTyUsOTHvYa0jQNl7TSaGRUXce0A-o~faOvwO3AaVhy0Fb7M42QAdTwv52KxqhuLR96V5Pt-gRAtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":37369,"name":"Translational Medicine","url":"https://www.academia.edu/Documents/in/Translational_Medicine"},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":295854,"name":"microRNAs","url":"https://www.academia.edu/Documents/in/microRNAs"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1810445,"name":"Gene expression profiling","url":"https://www.academia.edu/Documents/in/Gene_expression_profiling"},{"id":2940273,"name":"real time polymerase chain reaction","url":"https://www.academia.edu/Documents/in/real_time_polymerase_chain_reaction"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458010"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458010/Administration_of_MIP_3%CE%B1_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma"><img alt="Research paper thumbnail of Administration of MIP-3α gene to the tumor following radiation therapy boosts anti-tumor immunity in a murine model of lung carcinoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458010/Administration_of_MIP_3%CE%B1_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma">Administration of MIP-3α gene to the tumor following radiation therapy boosts anti-tumor immunity in a murine model of lung carcinoma</a></div><div class="wp-workCard_item"><span>Immunology Letters</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to pro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cells receiving radiation often produce the &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;danger signal&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; cytokines such as TNF-alpha and IL-1. Another cytokine MIP-3alpha that is able to attract DC to the tumor site is normally not secreted. We hypothesize that if artificial introduction of a large number of DC to the necrotic tumor site after radiation therapy by transfecting any cells at the tumor site to secrete DC-tropic MIP-3alpha, an anti-tumor immune response would be initiated. C57BL/6J mice bearing a well-known Lewis lung carcinoma are used to assess efficacy of this modality. The plasmid DNA containing pcDNA3.1/MIP-3alpha was injected into the subcutaneous tumors after radiation treatment. We demonstrate a detectable local expression of MIP-3alpha and local accumulation of DC. Tumor infiltrating lymphocytes after the treatment are predominantly CD8+ T-cells with rare CD4+ T-cells. The anti-tumor immune response was also measurable, which contributes at least in part to the finding that the treated mice have smaller tumor and prolonged survival, comparing to the control groups. This study suggests a potential new means of immune modulation and provides us a new concept of immunotherapy of cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458010"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458010"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458010; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458010]").text(description); $(".js-view-count[data-work-id=55458010]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458010; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458010']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458010, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55458010]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458010,"title":"Administration of MIP-3α gene to the tumor following radiation therapy boosts anti-tumor immunity in a murine model of lung carcinoma","translated_title":"","metadata":{"abstract":"Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cells receiving radiation often produce the \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;danger signal\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; cytokines such as TNF-alpha and IL-1. Another cytokine MIP-3alpha that is able to attract DC to the tumor site is normally not secreted. We hypothesize that if artificial introduction of a large number of DC to the necrotic tumor site after radiation therapy by transfecting any cells at the tumor site to secrete DC-tropic MIP-3alpha, an anti-tumor immune response would be initiated. C57BL/6J mice bearing a well-known Lewis lung carcinoma are used to assess efficacy of this modality. The plasmid DNA containing pcDNA3.1/MIP-3alpha was injected into the subcutaneous tumors after radiation treatment. We demonstrate a detectable local expression of MIP-3alpha and local accumulation of DC. Tumor infiltrating lymphocytes after the treatment are predominantly CD8+ T-cells with rare CD4+ T-cells. The anti-tumor immune response was also measurable, which contributes at least in part to the finding that the treated mice have smaller tumor and prolonged survival, comparing to the control groups. This study suggests a potential new means of immune modulation and provides us a new concept of immunotherapy of cancer.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Immunology Letters"},"translated_abstract":"Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cells receiving radiation often produce the \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;danger signal\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; cytokines such as TNF-alpha and IL-1. Another cytokine MIP-3alpha that is able to attract DC to the tumor site is normally not secreted. We hypothesize that if artificial introduction of a large number of DC to the necrotic tumor site after radiation therapy by transfecting any cells at the tumor site to secrete DC-tropic MIP-3alpha, an anti-tumor immune response would be initiated. C57BL/6J mice bearing a well-known Lewis lung carcinoma are used to assess efficacy of this modality. The plasmid DNA containing pcDNA3.1/MIP-3alpha was injected into the subcutaneous tumors after radiation treatment. We demonstrate a detectable local expression of MIP-3alpha and local accumulation of DC. Tumor infiltrating lymphocytes after the treatment are predominantly CD8+ T-cells with rare CD4+ T-cells. The anti-tumor immune response was also measurable, which contributes at least in part to the finding that the treated mice have smaller tumor and prolonged survival, comparing to the control groups. This study suggests a potential new means of immune modulation and provides us a new concept of immunotherapy of cancer.","internal_url":"https://www.academia.edu/55458010/Administration_of_MIP_3%CE%B1_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma","translated_internal_url":"","created_at":"2021-10-04T08:58:25.584-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Administration_of_MIP_3α_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7864,"name":"Gene Therapy","url":"https://www.academia.edu/Documents/in/Gene_Therapy"},{"id":10030,"name":"Radiation Therapy","url":"https://www.academia.edu/Documents/in/Radiation_Therapy"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":135250,"name":"Antigen Presentation","url":"https://www.academia.edu/Documents/in/Antigen_Presentation"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":183861,"name":"Immune modulation","url":"https://www.academia.edu/Documents/in/Immune_modulation"},{"id":190363,"name":"Plasmids","url":"https://www.academia.edu/Documents/in/Plasmids"},{"id":431152,"name":"CTL","url":"https://www.academia.edu/Documents/in/CTL"},{"id":951639,"name":"Murine Model","url":"https://www.academia.edu/Documents/in/Murine_Model"},{"id":1238057,"name":"PBMC","url":"https://www.academia.edu/Documents/in/PBMC"},{"id":1320136,"name":"Plasmid DNA","url":"https://www.academia.edu/Documents/in/Plasmid_DNA"},{"id":1554614,"name":"Lung Carcinoma","url":"https://www.academia.edu/Documents/in/Lung_Carcinoma"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group"},{"id":3061075,"name":"Genetic Therapy","url":"https://www.academia.edu/Documents/in/Genetic_Therapy"},{"id":3608309,"name":"tumor immunity","url":"https://www.academia.edu/Documents/in/tumor_immunity"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458008"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458008/CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice"><img alt="Research paper thumbnail of CD80, but not CD86 were up-regulated on the spleen-derived dendritic cells from OVA-sensitized and challenged BALB/c mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458008/CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice">CD80, but not CD86 were up-regulated on the spleen-derived dendritic cells from OVA-sensitized and challenged BALB/c mice</a></div><div class="wp-workCard_item"><span>Immunology Letters</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of allergic asthma. It is well established that T cells activation requires interaction of T cell receptor (TCR) and MHC-peptide complex, as well as costimulatory signal delivered by antigen presenting cells (APCs). There is increasing evidence that CD80 (B7.1) and CD86 (B7.2), as the most important costimulatory molecules, are involved in the allergic immune responses. In the present study, we investigated the CD80 and CD86 expression of spleen-derived dendritic cells (DCs) in a murine model of allergic asthma. We first established a murine model of ovalbumin (OVA)-allergic asthma that showed unique histological characteristic of allergic inflammation in the lung, high serum OVA-specific IgE level, high numbers of eosinophils in the bronchoalveolar lavage (BAL) and high production of Type 2 cytokines in the splenic T cells. In this model, we found that CD80 were significantly upregulated on the spleen-derived DCs from OVA-sensitized and challenged mice compared with that from PBS-treated or non-treated mice, while CD86 is not different among three groups. Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice. Our results suggest that DCs in the spleen of allergic mice, via upregulation of CD80 might play a pivotal role in the maintenance and amplification of allergic immune response, namely Th2 immune response.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458008"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458008"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458008; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458008]").text(description); $(".js-view-count[data-work-id=55458008]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458008; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458008']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458008, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55458008]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458008,"title":"CD80, but not CD86 were up-regulated on the spleen-derived dendritic cells from OVA-sensitized and challenged BALB/c mice","translated_title":"","metadata":{"abstract":"Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of allergic asthma. It is well established that T cells activation requires interaction of T cell receptor (TCR) and MHC-peptide complex, as well as costimulatory signal delivered by antigen presenting cells (APCs). There is increasing evidence that CD80 (B7.1) and CD86 (B7.2), as the most important costimulatory molecules, are involved in the allergic immune responses. In the present study, we investigated the CD80 and CD86 expression of spleen-derived dendritic cells (DCs) in a murine model of allergic asthma. We first established a murine model of ovalbumin (OVA)-allergic asthma that showed unique histological characteristic of allergic inflammation in the lung, high serum OVA-specific IgE level, high numbers of eosinophils in the bronchoalveolar lavage (BAL) and high production of Type 2 cytokines in the splenic T cells. In this model, we found that CD80 were significantly upregulated on the spleen-derived DCs from OVA-sensitized and challenged mice compared with that from PBS-treated or non-treated mice, while CD86 is not different among three groups. Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice. Our results suggest that DCs in the spleen of allergic mice, via upregulation of CD80 might play a pivotal role in the maintenance and amplification of allergic immune response, namely Th2 immune response.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Immunology Letters"},"translated_abstract":"Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of allergic asthma. It is well established that T cells activation requires interaction of T cell receptor (TCR) and MHC-peptide complex, as well as costimulatory signal delivered by antigen presenting cells (APCs). There is increasing evidence that CD80 (B7.1) and CD86 (B7.2), as the most important costimulatory molecules, are involved in the allergic immune responses. In the present study, we investigated the CD80 and CD86 expression of spleen-derived dendritic cells (DCs) in a murine model of allergic asthma. We first established a murine model of ovalbumin (OVA)-allergic asthma that showed unique histological characteristic of allergic inflammation in the lung, high serum OVA-specific IgE level, high numbers of eosinophils in the bronchoalveolar lavage (BAL) and high production of Type 2 cytokines in the splenic T cells. In this model, we found that CD80 were significantly upregulated on the spleen-derived DCs from OVA-sensitized and challenged mice compared with that from PBS-treated or non-treated mice, while CD86 is not different among three groups. Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice. Our results suggest that DCs in the spleen of allergic mice, via upregulation of CD80 might play a pivotal role in the maintenance and amplification of allergic immune response, namely Th2 immune response.","internal_url":"https://www.academia.edu/55458008/CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice","translated_internal_url":"","created_at":"2021-10-04T08:58:25.505-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":20212,"name":"Allergic asthma","url":"https://www.academia.edu/Documents/in/Allergic_asthma"},{"id":34021,"name":"T cell receptor","url":"https://www.academia.edu/Documents/in/T_cell_receptor"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen"},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":273338,"name":"IL","url":"https://www.academia.edu/Documents/in/IL"},{"id":662855,"name":"T cell activation","url":"https://www.academia.edu/Documents/in/T_cell_activation"},{"id":951639,"name":"Murine Model","url":"https://www.academia.edu/Documents/in/Murine_Model"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":2005397,"name":"Bronchoalveolar lavage","url":"https://www.academia.edu/Documents/in/Bronchoalveolar_lavage"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458007"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458007/Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice"><img alt="Research paper thumbnail of Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/71318131/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458007/Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice">Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice</a></div><div class="wp-workCard_item"><span>Genetic Vaccines and Therapy</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e933191b73a813b4911f333fdcde8d70" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318131,"asset_id":55458007,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318131/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458007"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458007"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458007; 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Objective: To evaluate effects and potential mechanisms of DNA vaccine containing ovalbumin (OVA) and Fc fusion on allergic airway inflammation. Methods: Bronchoalveolar lavage (BAL) levels of inflammatory mediators and leukocyte infiltration, expression of CD 11c + CD 80 + and CD 11c + CD 86 + co-stimulatory molecules in spleen dendritic cells (DCs), circulating CD 4 + and CD 8 + T cells, Foxp3 + in spleen CD 4 + T cells and spleen CD 4 + T cells were measured in OVA-sensitized and challenged animals pretreated with pcDNA, OVA-pcDNA, Fc-pcDNA, and OVA-Fc-pcDNA. Results: OVA-Sensitized and challenged mice developed airway inflammation and Th2 responses, and decreased the proliferation of peripheral CD 4 + and CD 8 + T cells and the number of spleen Foxp 3 + Treg. Those changes with increased INF-γ production and reduced OVA-specific IgE production were protected by the pretreatment with OVA-Fc-pcDNA. Conclusion: DNA vaccine encoding both Fc and OVA showed more effective than DNA vaccine encoding Fc or OVA alone, through the balance of DCs and Treg.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Genetic Vaccines and Therapy","grobid_abstract_attachment_id":71318131},"translated_abstract":null,"internal_url":"https://www.academia.edu/55458007/Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice","translated_internal_url":"","created_at":"2021-10-04T08:58:25.421-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71318131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318131/thumbnails/1.jpg","file_name":"pmc2861055.pdf","download_url":"https://www.academia.edu/attachments/71318131/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protection_against_the_allergic_airway_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318131/pmc2861055-libre.pdf?1633364842=\u0026response-content-disposition=attachment%3B+filename%3DProtection_against_the_allergic_airway_i.pdf\u0026Expires=1732742021\u0026Signature=XXSmVPszxD2R-~~tixWmXOnkgKZc6Rvc4QZ2Hv~MjQTrAbSF620atAp6FQOb3PVraPnqracr5uJvasEnylN3rL6ni9mnoy5xPe-x3NuGDtGj-PKNzukUn9QVY6EvBB2aAyxdGjyWjUQ9NSfh8DIIvarzd9nmoceau8qBcd52wGnhCPo9jGNG5ZxyeFrpewZct9RtJHuNV2Jh6ibDarxZCtwTqkbHA7DOZuuF3o9ytU-elxbFt9cAAVScuT1CnX2yXHgHkLiAnkDE4Dl1Rx3ZLyJw~I56bcjw1iQK6y7QWBjKJ2ttrpOAM5-pyDtgZKKkBL4pehx4JWtJK602~AcL-A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":71318131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318131/thumbnails/1.jpg","file_name":"pmc2861055.pdf","download_url":"https://www.academia.edu/attachments/71318131/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protection_against_the_allergic_airway_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318131/pmc2861055-libre.pdf?1633364842=\u0026response-content-disposition=attachment%3B+filename%3DProtection_against_the_allergic_airway_i.pdf\u0026Expires=1732742021\u0026Signature=XXSmVPszxD2R-~~tixWmXOnkgKZc6Rvc4QZ2Hv~MjQTrAbSF620atAp6FQOb3PVraPnqracr5uJvasEnylN3rL6ni9mnoy5xPe-x3NuGDtGj-PKNzukUn9QVY6EvBB2aAyxdGjyWjUQ9NSfh8DIIvarzd9nmoceau8qBcd52wGnhCPo9jGNG5ZxyeFrpewZct9RtJHuNV2Jh6ibDarxZCtwTqkbHA7DOZuuF3o9ytU-elxbFt9cAAVScuT1CnX2yXHgHkLiAnkDE4Dl1Rx3ZLyJw~I56bcjw1iQK6y7QWBjKJ2ttrpOAM5-pyDtgZKKkBL4pehx4JWtJK602~AcL-A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":664253,"name":"DNA vaccine","url":"https://www.academia.edu/Documents/in/DNA_vaccine"},{"id":2005397,"name":"Bronchoalveolar lavage","url":"https://www.academia.edu/Documents/in/Bronchoalveolar_lavage"},{"id":2188946,"name":"Airway Inflammation","url":"https://www.academia.edu/Documents/in/Airway_Inflammation"},{"id":2976793,"name":"Regulatory T cell","url":"https://www.academia.edu/Documents/in/Regulatory_T_cell"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458005"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458005/Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells"><img alt="Research paper thumbnail of Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458005/Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells">Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells</a></div><div class="wp-workCard_item"><span>Cancer Science</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation and cancer. Recently, we found that increased IL-17-producing cells correlate with poor survival and increased lymphangiogenesis in non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Here, we show that IL-17 promotes lymphangiogenesis via inducing vascular endothelial growth factor-C (VEGF-C) production by lung cancer cells. We found that IL-17 receptor (IL-17R) is expressed on the surface of Lewis lung carcinoma (LLC) cells but not on lymphatic endothelial cells (LEC). Moreover, LEC chemotaxis and tube formation (measures of net lymphangiogenic potential) were increased by conditioned medium from recombinant mouse IL-17 (rmIL-17)-stimulated LLC but not by rmIL-17. Interleukin-17 increased production of VEGF-C in lung cancer cell lines. The enhanced chemotaxis and endothelial cord formation in the presence of LLC/rmIL-17 was inhibited by addition of recombinant mouse VEGF R3/Fc chimera. Treatment of the A549 cells with rIL-17 significantly increased VEGF-C expression, which was extracellular signal-regulated protein kinase 1/2 (ERK 1/2) dependent. Importantly, we found significant correlations between IL-17 expression, VEGF-C expression and lymphatic vascular density (LVD) in NSCLC. We conclude that IL-17 is involved in lymphangiogenesis in NSCLC by enhancing production of VEGF-C, and IL-17 may be an important target for the treatment of NSCLC.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458005"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458005"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458005; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458005]").text(description); $(".js-view-count[data-work-id=55458005]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458005; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458005']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458005, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55458005]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458005,"title":"Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells","translated_title":"","metadata":{"abstract":"Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation and cancer. Recently, we found that increased IL-17-producing cells correlate with poor survival and increased lymphangiogenesis in non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Here, we show that IL-17 promotes lymphangiogenesis via inducing vascular endothelial growth factor-C (VEGF-C) production by lung cancer cells. We found that IL-17 receptor (IL-17R) is expressed on the surface of Lewis lung carcinoma (LLC) cells but not on lymphatic endothelial cells (LEC). Moreover, LEC chemotaxis and tube formation (measures of net lymphangiogenic potential) were increased by conditioned medium from recombinant mouse IL-17 (rmIL-17)-stimulated LLC but not by rmIL-17. Interleukin-17 increased production of VEGF-C in lung cancer cell lines. The enhanced chemotaxis and endothelial cord formation in the presence of LLC/rmIL-17 was inhibited by addition of recombinant mouse VEGF R3/Fc chimera. Treatment of the A549 cells with rIL-17 significantly increased VEGF-C expression, which was extracellular signal-regulated protein kinase 1/2 (ERK 1/2) dependent. Importantly, we found significant correlations between IL-17 expression, VEGF-C expression and lymphatic vascular density (LVD) in NSCLC. We conclude that IL-17 is involved in lymphangiogenesis in NSCLC by enhancing production of VEGF-C, and IL-17 may be an important target for the treatment of NSCLC.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Cancer Science"},"translated_abstract":"Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation and cancer. Recently, we found that increased IL-17-producing cells correlate with poor survival and increased lymphangiogenesis in non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Here, we show that IL-17 promotes lymphangiogenesis via inducing vascular endothelial growth factor-C (VEGF-C) production by lung cancer cells. We found that IL-17 receptor (IL-17R) is expressed on the surface of Lewis lung carcinoma (LLC) cells but not on lymphatic endothelial cells (LEC). Moreover, LEC chemotaxis and tube formation (measures of net lymphangiogenic potential) were increased by conditioned medium from recombinant mouse IL-17 (rmIL-17)-stimulated LLC but not by rmIL-17. Interleukin-17 increased production of VEGF-C in lung cancer cell lines. The enhanced chemotaxis and endothelial cord formation in the presence of LLC/rmIL-17 was inhibited by addition of recombinant mouse VEGF R3/Fc chimera. Treatment of the A549 cells with rIL-17 significantly increased VEGF-C expression, which was extracellular signal-regulated protein kinase 1/2 (ERK 1/2) dependent. Importantly, we found significant correlations between IL-17 expression, VEGF-C expression and lymphatic vascular density (LVD) in NSCLC. We conclude that IL-17 is involved in lymphangiogenesis in NSCLC by enhancing production of VEGF-C, and IL-17 may be an important target for the treatment of NSCLC.","internal_url":"https://www.academia.edu/55458005/Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells","translated_internal_url":"","created_at":"2021-10-04T08:58:25.335-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":32722,"name":"Lymphangiogenesis","url":"https://www.academia.edu/Documents/in/Lymphangiogenesis"},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":170276,"name":"Chemotaxis","url":"https://www.academia.edu/Documents/in/Chemotaxis"},{"id":213910,"name":"Mitogen Activated Protein Kinase","url":"https://www.academia.edu/Documents/in/Mitogen_Activated_Protein_Kinase"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins"},{"id":1166930,"name":"Cytoplasm","url":"https://www.academia.edu/Documents/in/Cytoplasm"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":3067128,"name":"reverse transcriptase polymerase chain reaction","url":"https://www.academia.edu/Documents/in/reverse_transcriptase_polymerase_chain_reaction"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458003"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458003/IL_17_is_associated_with_poor_prognosis_and_promotes_angiogenesis_via_stimulating_VEGF_production_of_cancer_cells_in_colorectal_carcinoma"><img alt="Research paper thumbnail of IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma" class="work-thumbnail" src="https://attachments.academia-assets.com/71318139/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458003/IL_17_is_associated_with_poor_prognosis_and_promotes_angiogenesis_via_stimulating_VEGF_production_of_cancer_cells_in_colorectal_carcinoma">IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma</a></div><div class="wp-workCard_item"><span>Biochemical and Biophysical Research Communications</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="24d45d836064d1c2a987980595047692" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318139,"asset_id":55458003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318139/download_file?st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458003; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458003]").text(description); $(".js-view-count[data-work-id=55458003]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458003; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458003']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458003, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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However, the characteristics of IL-17-producing cells, the relevance of IL-17 to clinical parameters and its function in the development and progression of colorectal carcinoma still remain to be explored. In the present study, we first found the levels of IL-17 producing cells were significantly increased in the tumor regions of samples from colorectal carcinoma patients compared with non-tumor regions. Confocal microscopic analysis showed co-staining of IL-17 with CD4 and CD68, indicating IL-17 in colorectal carcinoma was expressed by macrophage and Th17. High expression of IL-17 was associated with high microvessel density. Univariate and multivariate analysis revealed that IL-17 was an independent prognostic factor for overall survival. To explore the underlying mechanisms of IL-17 in angiogenesis, we used PCR-array to find pro-angiogenic factor in cancer cells specifically induced by IL-17, then validated VEGF as one of factors in IL-17-mediated angiogenesis with the use of quantitative RT-PCR, ELISA and VEGF immunohistochemistry. Our results propose IL-17 as a novel indicator of prognosis in the patients with colorectal carcinoma and could serve as a novel therapeutic target for colorectal carcinoma, furthermore our results indicate that IL-17 producing cells may facilitate development of colorectal carcinoma by fostering angiogenesis via promote VEGF production from cancer cells.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Biochemical and Biophysical Research 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RT-PCR","url":"https://www.academia.edu/Documents/in/quantitative_RT-PCR"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55457996"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55457996/Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice"><img alt="Research paper thumbnail of Roles of costimulatory molecules in pulmonary dendritic cells in the development of asthma in mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55457996/Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice">Roles of costimulatory molecules in pulmonary dendritic cells in the development of asthma in mice</a></div><div class="wp-workCard_item"><span>Chinese Journal of Lung Diseases (Electronic Version)</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducing and modulating immune responses in a murine asthma model. Methods Murine asthma model, established with ovalbumin (OVA) sensitization and challenge, was confirmed by histological analysis of the lung tissues, cell count and differentiation of bronchoalveolar lavage fluid (BALF), serum OVA-specific IgE level, and the levels of IL-4, IL-5 and IFN-g in BALF by ELISA. The purity of pulmonary dendritic cells was assayed with ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55457996"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55457996"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55457996; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55457996]").text(description); $(".js-view-count[data-work-id=55457996]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55457996; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55457996']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55457996, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55457996]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55457996,"title":"Roles of costimulatory molecules in pulmonary dendritic cells in the development of asthma in mice","translated_title":"","metadata":{"abstract":"Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducing and modulating immune responses in a murine asthma model. Methods Murine asthma model, established with ovalbumin (OVA) sensitization and challenge, was confirmed by histological analysis of the lung tissues, cell count and differentiation of bronchoalveolar lavage fluid (BALF), serum OVA-specific IgE level, and the levels of IL-4, IL-5 and IFN-g in BALF by ELISA. The purity of pulmonary dendritic cells was assayed with ...","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Chinese Journal of Lung Diseases (Electronic Version)"},"translated_abstract":"Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducing and modulating immune responses in a murine asthma model. Methods Murine asthma model, established with ovalbumin (OVA) sensitization and challenge, was confirmed by histological analysis of the lung tissues, cell count and differentiation of bronchoalveolar lavage fluid (BALF), serum OVA-specific IgE level, and the levels of IL-4, IL-5 and IFN-g in BALF by ELISA. The purity of pulmonary dendritic cells was assayed with ...","internal_url":"https://www.academia.edu/55457996/Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice","translated_internal_url":"","created_at":"2021-10-04T08:58:24.655-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55457991"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55457991/Research_Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice"><img alt="Research paper thumbnail of Research Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/71318050/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55457991/Research_Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice">Research Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BioMedCentral © 2010 Wang et al; licensee BioMed Central Ltd. This is an Open Access article dist...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BioMedCentral © 2010 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<a href="http://creativecommons.org/licenses/by/2.0" rel="nofollow">http://creativecommons.org/licenses/by/2.0</a>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ... Research Protection against the allergic airway inflammation ... 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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ... Research Protection against the allergic airway inflammation ... Yaoli Wang1,2,3, Chunxue Bai2, Guansong Wang1, Diane Wang, Xiaoming Cheng1, Jian Huang, Dongpo Jiang, Guisheng Qian1 ...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}}},"translated_abstract":"BioMedCentral © 2010 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ... Research Protection against the allergic airway inflammation ... Yaoli Wang1,2,3, Chunxue Bai2, Guansong Wang1, Diane Wang, Xiaoming Cheng1, Jian Huang, Dongpo Jiang, Guisheng Qian1 ...","internal_url":"https://www.academia.edu/55457991/Research_Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice","translated_internal_url":"","created_at":"2021-10-04T08:58:24.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71318050,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318050/thumbnails/1.jpg","file_name":"1479-0556-8-2.pdf","download_url":"https://www.academia.edu/attachments/71318050/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Research_Protection_against_the_allergic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318050/1479-0556-8-2-libre.pdf?1633364847=\u0026response-content-disposition=attachment%3B+filename%3DResearch_Protection_against_the_allergic.pdf\u0026Expires=1732742021\u0026Signature=CqeHHpGmgASxJYmV2NgZGhm-CePKxSz4aLuqfNbXPbHv20OWs4AzIpDUqnP-a-525nrFly4ftOoUxzsHE~Zb5AWyLYyKNDAOpId~v-JQZIchaGN-yuIfrUAn1ClNVBe~nNDgyeN3ondT7jCYlhOjdtcJ~jJ6JtLnn-luUjNwM1ieZz8fur8H8NL8jKF7Ecdx1hYTQKsRLR9u23-1eXXA3ZwYuRXmypHJvP~NgbLS0GOKXutRT-fx0btwnR5kOnbffAT~pSL0oQOCSJLSgcl3lGIzPlEdWAhBLGZXlsMbrplO6ZvtMSIw8bac9c9fwTpkEuzPsLhntTBLS0pDb3jgvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Research_Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":71318050,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318050/thumbnails/1.jpg","file_name":"1479-0556-8-2.pdf","download_url":"https://www.academia.edu/attachments/71318050/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Research_Protection_against_the_allergic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318050/1479-0556-8-2-libre.pdf?1633364847=\u0026response-content-disposition=attachment%3B+filename%3DResearch_Protection_against_the_allergic.pdf\u0026Expires=1732742021\u0026Signature=CqeHHpGmgASxJYmV2NgZGhm-CePKxSz4aLuqfNbXPbHv20OWs4AzIpDUqnP-a-525nrFly4ftOoUxzsHE~Zb5AWyLYyKNDAOpId~v-JQZIchaGN-yuIfrUAn1ClNVBe~nNDgyeN3ondT7jCYlhOjdtcJ~jJ6JtLnn-luUjNwM1ieZz8fur8H8NL8jKF7Ecdx1hYTQKsRLR9u23-1eXXA3ZwYuRXmypHJvP~NgbLS0GOKXutRT-fx0btwnR5kOnbffAT~pSL0oQOCSJLSgcl3lGIzPlEdWAhBLGZXlsMbrplO6ZvtMSIw8bac9c9fwTpkEuzPsLhntTBLS0pDb3jgvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":71318051,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318051/thumbnails/1.jpg","file_name":"1479-0556-8-2.pdf","download_url":"https://www.academia.edu/attachments/71318051/download_file","bulk_download_file_name":"Research_Protection_against_the_allergic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318051/1479-0556-8-2-libre.pdf?1633364847=\u0026response-content-disposition=attachment%3B+filename%3DResearch_Protection_against_the_allergic.pdf\u0026Expires=1732742021\u0026Signature=cVGCHeu~w7KhczMAvYRW8mOboUZrqp84Aiq2WmNnM15MFSmjTP1~IxqyV4SmGFsuc24ARNycKegDwzkkL2R039IM4T~ZhzDdtfNM25p2JwB-~PIrznWfedksCtWRQiujEPVS~lYXWv32yvdQ2e14L26NKUH~EVGtPmOoNLG8DL39X~VmrlBp4bVfrWJlZcvCPOVjmK6naqM~apw~u6H501cqsTvjz1uaS~otr70SjREML9knt3ad7f8UYZaH6cP7jkoTrKuzNR9F87NH2tG8gZ9rnzsujnkWBetRmlsH8XI68M4ZAlyRcOG1I48VkaBOfMs5kx8-jafkJvnJ0nEvwg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":12201211,"url":"http://www.biomedcentral.com/content/pdf/1479-0556-8-2.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55452403"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55452403/Chinese_expert_consensus_based_guideline_on_assessment_and_management_of_asthma_exacerbation"><img alt="Research paper thumbnail of Chinese expert consensus-based guideline on assessment and management of asthma exacerbation" class="work-thumbnail" src="https://attachments.academia-assets.com/71315100/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55452403/Chinese_expert_consensus_based_guideline_on_assessment_and_management_of_asthma_exacerbation">Chinese expert consensus-based guideline on assessment and management of asthma exacerbation</a></div><div class="wp-workCard_item"><span>Journal of Thoracic Disease</span><span>, Dec 1, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c5243556ebf0a4b9fec3dab815a47ca8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71315100,"asset_id":55452403,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71315100/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55452403"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55452403"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55452403; 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Asthma exacerbation as one of critical component of the future risks (1,2), may induce a variety of harms to the host, necessitate additional use of medical resources, impose serious socioeconomic burdens, and represent a significant cause of asthma-related disability and mortality (3). As such, prevention and reduction of the asthma exacerbation are of important relevance in improving the overall control of asthma (2-5). In diagnosing and treating asthma exacerbation, the expertise of clinicians in Chinese hospitals of varied levels has currently been compromised by less standard practicing due to a number of subjective or objective factors. This also results in increased medical cost (3). To standardize the practicing, renew the understandings on diagnosis and treatment, and improve the care for asthma exacerbation, the China Asthma Alliance (CAA) has developed this consensus document based on in-depth discussion among a summoned panel of Chinese experts in related fields, with reference to relevant international guidelines (1,6,7) and focused articles appearing within and outside the country in the past few years. The document is desired to offer guidance and evidence for diagnosis, treatment, prevention and management of asthma exacerbation in clinical settings, as well as related studies. Definition Asthma exacerbation is defined as sudden onset of symptoms like wheezing, shortness of breath, cough and chest tightness, or worsening of the current symptoms, typically associated with dyspnea and characterized by reduced expiratory flow, and usually requires adjustment of medications (1,6,7). Although sometimes it can be an initial manifestation, asthma exacerbation more likely occurs in patients with confirmed asthma, and in most of times, is triggered by exposure to allergens or irritants, respiratory infections or poor patient adherence to controller medications (5,7), despite unclear predisposing factors in fewer patients. 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It is correctly pointed out that multiple scans may mean a significantly increased lifetime attributable risk of cancer when estimated from prior studies of atomic bomb survivors and workers in the nuclear industry [1]. However, it would be remiss to not point out that the risk of cancer from a CCT is not particularly daunting in adults aged .50 yrs with ,0.02% lifetime attributable risk per abdominal CT; this is comparable in radiation exposure to our institutions CT pulmonary angiography and less than our non-contrast CCT. As the PORT study found that 74.6% of 1,343 in-patients were aged .50 yrs, it seems likely that CCT would be a fairly safe modality in the majority of hospitalised pneumonia patients [2]. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="5379662" id="papers"><div class="js-work-strip profile--work_container" data-work-id="121716252"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121716252/Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation"><img alt="Research paper thumbnail of Potential therapy of Fc-antigen combination-encoding DNA vaccination in mouse allergic airway inflammation" class="work-thumbnail" src="https://attachments.academia-assets.com/116531029/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121716252/Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation">Potential therapy of Fc-antigen combination-encoding DNA vaccination in mouse allergic airway inflammation</a></div><div class="wp-workCard_item"><span>Clinical & Experimental Immunology</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ec86dee72bf83c607116ba2f0c51c1a8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116531029,"asset_id":121716252,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116531029/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121716252"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121716252"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121716252; 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In this study, we examine the therapeutic effect of allergen-encoding DNA vaccination directly to dendritic cells (DCs) on allergen-induced allergic airway inflammation in a mouse model and explore potential mechanism. Ovalbumin (OVA)-sensitized and challenged mice were immunized with DNA vaccine and received bronchoalveolar lavage (BAL) 1 day after the last challenge, to measure BAL levels of interleukin (IL)-4, IL-5, interferon (IFN)-gamma and differential cell count. Pulmonary DCs and Spleen DCs were purified and sorted according to the expression of CD11c + CD80 + and CD11c + CD86 + co-stimulatory molecules. Our data demonstrated that DNA vaccine therapy with OVA-Fc-pcDNA3•1 significantly prevented OVA-increased levels of IL-4, IL-5 and the percentage of eosinophils and OVA-decreased level of IFN-gamma. OVA-Fc-pcDNA3•1treated mice had less severity of airway inflammation, and lower expression of CD11c + CD80 + and CD11c + CD86 + on pulmonary DCs, as compared with animals with OVA-pcDNA3•1, pcDNA3•1 and OVA respectively. DNA vaccine encoding both Fc and OVA was shown to be more effective than DNA vaccine encoding OVA alone. Our data indicate that Fc-antigen combinationencoding DNA vaccination has better preventive effects on antigen-induced airway inflammation by regulating DCs, and may be a new alternative therapy for asthma.","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Clinical \u0026 Experimental Immunology","grobid_abstract_attachment_id":116531029},"translated_abstract":null,"internal_url":"https://www.academia.edu/121716252/Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation","translated_internal_url":"","created_at":"2024-07-02T06:16:21.183-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":116531029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116531029/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116531029/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Potential_therapy_of_Fc_antigen_combinat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116531029/pdf-libre.pdf?1719926409=\u0026response-content-disposition=attachment%3B+filename%3DPotential_therapy_of_Fc_antigen_combinat.pdf\u0026Expires=1732742020\u0026Signature=V4RR8iou2eGBAeivpjLuV1jqN4RCtsasHQ-L5R39xu~0qmdm53JrVJO7SJdADZxKWVxoSesDOz~XVMY4FNOx5F9yDwwl~vpiYjM50-0RTK~a58tdeH~io2M4cbAMnuh1tZcle2nPrLFhyfgvQW2QEKs7-DQtLERDAoo-uaAnWbEf3K-oYcM~NycGvQJFDY7tpn7PC5RlwWmcUMLXAcjz8etTv17S9eghgQmf8fOt66shoLOI6iAHLIyVTOzhvcN51Aw9cOvnqcu4oFYtGGWqKPjaI6B~oaURFCe3jehj3shbVvbHbJyO5B8R1xi4sqopbfjKfQAio4cxl90HE0bEHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Potential_therapy_of_Fc_antigen_combination_encoding_DNA_vaccination_in_mouse_allergic_airway_inflammation","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":116531029,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116531029/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116531029/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Potential_therapy_of_Fc_antigen_combinat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116531029/pdf-libre.pdf?1719926409=\u0026response-content-disposition=attachment%3B+filename%3DPotential_therapy_of_Fc_antigen_combinat.pdf\u0026Expires=1732742020\u0026Signature=V4RR8iou2eGBAeivpjLuV1jqN4RCtsasHQ-L5R39xu~0qmdm53JrVJO7SJdADZxKWVxoSesDOz~XVMY4FNOx5F9yDwwl~vpiYjM50-0RTK~a58tdeH~io2M4cbAMnuh1tZcle2nPrLFhyfgvQW2QEKs7-DQtLERDAoo-uaAnWbEf3K-oYcM~NycGvQJFDY7tpn7PC5RlwWmcUMLXAcjz8etTv17S9eghgQmf8fOt66shoLOI6iAHLIyVTOzhvcN51Aw9cOvnqcu4oFYtGGWqKPjaI6B~oaURFCe3jehj3shbVvbHbJyO5B8R1xi4sqopbfjKfQAio4cxl90HE0bEHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":166422,"name":"DNA vaccines","url":"https://www.academia.edu/Documents/in/DNA_vaccines"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E"},{"id":179934,"name":"Vaccination","url":"https://www.academia.edu/Documents/in/Vaccination"},{"id":207341,"name":"DNA vaccination","url":"https://www.academia.edu/Documents/in/DNA_vaccination"},{"id":371516,"name":"Eosinophils","url":"https://www.academia.edu/Documents/in/Eosinophils"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"},{"id":3508723,"name":"Ovalbumin ","url":"https://www.academia.edu/Documents/in/Ovalbumin"},{"id":4075992,"name":"Immunoglobulin Fc Fragments","url":"https://www.academia.edu/Documents/in/Immunoglobulin_Fc_Fragments"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458023"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458023/Lung_Defense_through_Interleukin_8_Carries_a_Cost_of_Chronic_Lung_Remodeling_and_Impaired_Function"><img alt="Research paper thumbnail of Lung Defense through Interleukin-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function" class="work-thumbnail" src="https://attachments.academia-assets.com/71318140/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458023/Lung_Defense_through_Interleukin_8_Carries_a_Cost_of_Chronic_Lung_Remodeling_and_Impaired_Function">Lung Defense through Interleukin-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function</a></div><div class="wp-workCard_item"><span>American journal of respiratory cell and molecular biology</span><span>, Jan 12, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, ye...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases including COPD, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible pathologic, changes associated with elevated levels of IL-8 in the lung. To better understand the duality of IL-8 dependent host immunity to bacterial infection and lung pathology, we targeted human IL-8 to express transgenically in murine bronchial epithelium, investigating the impact of over-expression on lung bacterial clearance, host immunity, lung pathology and function. Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation, activation and chemtoaxis. There was enhanced protection from challenge with Pseudomonas aeruginosa and significant changes in baseline expression of innate and adaptive immunity transcripts for Ccl5, Tlr6, IL2 and Tlr1. There was increased expression of Tbet and Foxp3 in response to the Pseudomona...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d7832bbb5b3c2cfa2ad34848434f354" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318140,"asset_id":55458023,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318140/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458023"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458023"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458023; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458023]").text(description); $(".js-view-count[data-work-id=55458023]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458023; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458023']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458023, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d7832bbb5b3c2cfa2ad34848434f354" } } $('.js-work-strip[data-work-id=55458023]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458023,"title":"Lung Defense through Interleukin-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function","translated_title":"","metadata":{"abstract":"IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases including COPD, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible pathologic, changes associated with elevated levels of IL-8 in the lung. To better understand the duality of IL-8 dependent host immunity to bacterial infection and lung pathology, we targeted human IL-8 to express transgenically in murine bronchial epithelium, investigating the impact of over-expression on lung bacterial clearance, host immunity, lung pathology and function. Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation, activation and chemtoaxis. There was enhanced protection from challenge with Pseudomonas aeruginosa and significant changes in baseline expression of innate and adaptive immunity transcripts for Ccl5, Tlr6, IL2 and Tlr1. There was increased expression of Tbet and Foxp3 in response to the Pseudomona...","publication_date":{"day":12,"month":1,"year":2018,"errors":{}},"publication_name":"American journal of respiratory cell and molecular biology"},"translated_abstract":"IL-8 dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases including COPD, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible pathologic, changes associated with elevated levels of IL-8 in the lung. To better understand the duality of IL-8 dependent host immunity to bacterial infection and lung pathology, we targeted human IL-8 to express transgenically in murine bronchial epithelium, investigating the impact of over-expression on lung bacterial clearance, host immunity, lung pathology and function. Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation, activation and chemtoaxis. There was enhanced protection from challenge with Pseudomonas aeruginosa and significant changes in baseline expression of innate and adaptive immunity transcripts for Ccl5, Tlr6, IL2 and Tlr1. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458020"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458020/Targeting_the_Wnt_regulatory_protein_CTNNBIP1_by_microRNA_214_enhances_the_stemness_and_self_renewal_of_cancer_stem_like_cells_in_lung_adenocarcinomas"><img alt="Research paper thumbnail of Targeting the Wnt-regulatory protein CTNNBIP1 by microRNA-214 enhances the stemness and self-renewal of cancer stem-like cells in lung adenocarcinomas" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458020/Targeting_the_Wnt_regulatory_protein_CTNNBIP1_by_microRNA_214_enhances_the_stemness_and_self_renewal_of_cancer_stem_like_cells_in_lung_adenocarcinomas">Targeting the Wnt-regulatory protein CTNNBIP1 by microRNA-214 enhances the stemness and self-renewal of cancer stem-like cells in lung adenocarcinomas</a></div><div class="wp-workCard_item"><span>Stem cells (Dayton, Ohio)</span><span>, Jan 24, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A novel hypothesis in cancer biology proposes that cancer growth is driven by cancer stem-like ce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A novel hypothesis in cancer biology proposes that cancer growth is driven by cancer stem-like cells (CSLCs), also called tumor-initiating cells, which can self-renew and differentiate into multi-lineage progeny in a fashion similar to stem cells. However, the impact and underlying mechanisms of this process in lung adenocarcinoma (LAC) remains to be elucidated. Here, we report that microRNA-214 (miR-214) contributes to cell self-renewal by directly targeting CTNNBIP1, a member of the Wnt signaling pathway. We demonstrate that miR-214 overexpression enhances stem-like properties in LAC cells and that miR-214 shows increased expression in CSLCs derived from primary tumor tissue and from two LAC cell lines (A549 and NCI-H1650). Strikingly, down-regulation of miR-214 expression in CSLCs resulted in a significant decrease in spheroid formation and the expression of the stem-cell markers Nanog, Oct-4, and Sox-2. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458017"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55458017/Idiopathic_airway_centered_interstitial_fibrosis_report_of_two_cases"><img alt="Research paper thumbnail of Idiopathic airway-centered interstitial fibrosis: report of two cases" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55458017/Idiopathic_airway_centered_interstitial_fibrosis_report_of_two_cases">Idiopathic airway-centered interstitial fibrosis: report of two cases</a></div><div class="wp-workCard_item"><span>Chinese medical journal</span><span>, Jan 5, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458017"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458017"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458017; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458016"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55458016/_Airway_centered_interstitial_fibrosis_"><img alt="Research paper thumbnail of [Airway-centered interstitial fibrosis]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55458016/_Airway_centered_interstitial_fibrosis_">[Airway-centered interstitial fibrosis]</a></div><div class="wp-workCard_item"><span>Zhonghua bing li xue za zhi Chinese journal of pathology</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458016"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458016"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458016; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458014"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458014/Metformin_inhibits_the_IL_6_induced_epithelial_mesenchymal_transition_and_lung_adenocarcinoma_growth_and_metastasis"><img alt="Research paper thumbnail of Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis" class="work-thumbnail" src="https://attachments.academia-assets.com/71318134/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458014/Metformin_inhibits_the_IL_6_induced_epithelial_mesenchymal_transition_and_lung_adenocarcinoma_growth_and_metastasis">Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. However,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. However, the underlying mechanisms of EMT in lung adenocarcinoma, and how this process might be inhibited, remain to be explored. This study investigated the role of IL-6 in lung adenocarcinoma cell EMT and explored the potential effects of metformin on this process. Invasion assay and MTT assay was performed to determine cell invasion and cell proliferation. Western blotting, immunofluorescence, real-time PCR, ELISA, and immunohistochemistry were performed to detect the expression of IL-6, E-cadherin, Vimentin, and p-STAT3. We discovered that IL-6, via STAT3 phosphorylation, could promote lung adenocarcinoma cell invasion via EMT in vitro. This was supported by the inverse correlation between E-cadherin and IL-6 expression, positive correlation between IL-6 and vimentin mRNA expression and between STAT3 phosphorylation and IL-6 expression in tumor tissues. Importantly, metformin inhibited tumor...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ccc32f870f090f4d47652b9b6dce74f2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318134,"asset_id":55458014,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318134/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458014"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458014"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458014; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458014]").text(description); $(".js-view-count[data-work-id=55458014]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458014; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458014']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458014, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ccc32f870f090f4d47652b9b6dce74f2" } } $('.js-work-strip[data-work-id=55458014]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458014,"title":"Metformin inhibits the IL-6-induced epithelial-mesenchymal transition and lung adenocarcinoma growth and metastasis","translated_title":"","metadata":{"abstract":"Epithelial-mesenchymal transition (EMT) plays an important role in cancer tumorigenesis. 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alt="Research paper thumbnail of Induction of TRAG-3 expression in A549 lung adenocarcinoma cell line by 5-aza-2′ deoxyazacytidine" class="work-thumbnail" src="https://attachments.academia-assets.com/71318141/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458013/Induction_of_TRAG_3_expression_in_A549_lung_adenocarcinoma_cell_line_by_5_aza_2_deoxyazacytidine">Induction of TRAG-3 expression in A549 lung adenocarcinoma cell line by 5-aza-2′ deoxyazacytidine</a></div><div class="wp-workCard_item"><span>Lung Cancer</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0dec8a9f936330b13f6b34ed490db553" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458012/Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma"><img alt="Research paper thumbnail of Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma" class="work-thumbnail" src="https://attachments.academia-assets.com/71318143/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458012/Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma">Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma</a></div><div class="wp-workCard_item"><span>Journal of Translational Medicine</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor cells but come into apoptosis in a certain period and the latter is static with the ability of self-renewal. Previous studies showed that microRNAs (miRNA) played critical roles in regulating adaptive immunity. This study aimed to identify the different expression of miRNAs between Te and Tm cells in tumor-bearing mice and to sort out the target miRNAs which can be regulated to improve anti-tumor activities of CD8+ T cells. Methods miRNA expression profiling was performed on CD8+ Te and Tm cells from mice with Lewis lung carcinoma. Differentially expressed miRNA (miRNA-15b) was chosen and analyzed by qRT-PCR. Then, flow cytometry, ELISA, and CFSE kit were used to evaluate the biological effects of miRNA-15b on apoptosis, cytokine secretion, phenotype, and proliferat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="67d41a4685dee50f5c6239c3715ab2b6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318143,"asset_id":55458012,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318143/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458012"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458012"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458012; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458012]").text(description); $(".js-view-count[data-work-id=55458012]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458012; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458012']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458012, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "67d41a4685dee50f5c6239c3715ab2b6" } } $('.js-work-strip[data-work-id=55458012]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458012,"title":"Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma","translated_title":"","metadata":{"abstract":"Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor cells but come into apoptosis in a certain period and the latter is static with the ability of self-renewal. Previous studies showed that microRNAs (miRNA) played critical roles in regulating adaptive immunity. This study aimed to identify the different expression of miRNAs between Te and Tm cells in tumor-bearing mice and to sort out the target miRNAs which can be regulated to improve anti-tumor activities of CD8+ T cells. Methods miRNA expression profiling was performed on CD8+ Te and Tm cells from mice with Lewis lung carcinoma. Differentially expressed miRNA (miRNA-15b) was chosen and analyzed by qRT-PCR. Then, flow cytometry, ELISA, and CFSE kit were used to evaluate the biological effects of miRNA-15b on apoptosis, cytokine secretion, phenotype, and proliferat...","publisher":"Springer Nature","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of Translational Medicine"},"translated_abstract":"Background CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor cells but come into apoptosis in a certain period and the latter is static with the ability of self-renewal. Previous studies showed that microRNAs (miRNA) played critical roles in regulating adaptive immunity. This study aimed to identify the different expression of miRNAs between Te and Tm cells in tumor-bearing mice and to sort out the target miRNAs which can be regulated to improve anti-tumor activities of CD8+ T cells. Methods miRNA expression profiling was performed on CD8+ Te and Tm cells from mice with Lewis lung carcinoma. Differentially expressed miRNA (miRNA-15b) was chosen and analyzed by qRT-PCR. Then, flow cytometry, ELISA, and CFSE kit were used to evaluate the biological effects of miRNA-15b on apoptosis, cytokine secretion, phenotype, and proliferat...","internal_url":"https://www.academia.edu/55458012/Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma","translated_internal_url":"","created_at":"2021-10-04T08:58:25.664-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71318143,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318143/thumbnails/1.jpg","file_name":"PMC3608092.pdf","download_url":"https://www.academia.edu/attachments/71318143/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamically_expressed_microRNA_15b_modul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318143/PMC3608092-libre.pdf?1633364843=\u0026response-content-disposition=attachment%3B+filename%3DDynamically_expressed_microRNA_15b_modul.pdf\u0026Expires=1732742021\u0026Signature=CT1yeXKVTfgXhcB4hASI18uQ6nZghXb0-VZajUwJEfOVY28sGjPihG-POmOJVI0WibQcSJ2EJTIZSvFL3W7ts1jaMu90W5JAGW-Ox3XUpo5BtQt2Xak~EB58ggTlIJhkFUdWp28tK-Zspdr7Wu8RZs6UKsPULEoJqZxd1mTGN6dEhOHseA8xE2krGX9Qo0zfWCRgJuy-MeZWP159~6lzYQGoFjG94wg0tL-NlR7T1wu07TaVJk4svP6jtGy7czBAEyfxn9gjlaTyUsOTHvYa0jQNl7TSaGRUXce0A-o~faOvwO3AaVhy0Fb7M42QAdTwv52KxqhuLR96V5Pt-gRAtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dynamically_expressed_microRNA_15b_modulates_the_activities_of_CD8_T_lymphocytes_in_mice_with_Lewis_lung_carcinoma","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":71318143,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318143/thumbnails/1.jpg","file_name":"PMC3608092.pdf","download_url":"https://www.academia.edu/attachments/71318143/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dynamically_expressed_microRNA_15b_modul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318143/PMC3608092-libre.pdf?1633364843=\u0026response-content-disposition=attachment%3B+filename%3DDynamically_expressed_microRNA_15b_modul.pdf\u0026Expires=1732742021\u0026Signature=CT1yeXKVTfgXhcB4hASI18uQ6nZghXb0-VZajUwJEfOVY28sGjPihG-POmOJVI0WibQcSJ2EJTIZSvFL3W7ts1jaMu90W5JAGW-Ox3XUpo5BtQt2Xak~EB58ggTlIJhkFUdWp28tK-Zspdr7Wu8RZs6UKsPULEoJqZxd1mTGN6dEhOHseA8xE2krGX9Qo0zfWCRgJuy-MeZWP159~6lzYQGoFjG94wg0tL-NlR7T1wu07TaVJk4svP6jtGy7czBAEyfxn9gjlaTyUsOTHvYa0jQNl7TSaGRUXce0A-o~faOvwO3AaVhy0Fb7M42QAdTwv52KxqhuLR96V5Pt-gRAtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":37369,"name":"Translational Medicine","url":"https://www.academia.edu/Documents/in/Translational_Medicine"},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":295854,"name":"microRNAs","url":"https://www.academia.edu/Documents/in/microRNAs"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":1810445,"name":"Gene expression profiling","url":"https://www.academia.edu/Documents/in/Gene_expression_profiling"},{"id":2940273,"name":"real time polymerase chain reaction","url":"https://www.academia.edu/Documents/in/real_time_polymerase_chain_reaction"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458010"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458010/Administration_of_MIP_3%CE%B1_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma"><img alt="Research paper thumbnail of Administration of MIP-3α gene to the tumor following radiation therapy boosts anti-tumor immunity in a murine model of lung carcinoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458010/Administration_of_MIP_3%CE%B1_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma">Administration of MIP-3α gene to the tumor following radiation therapy boosts anti-tumor immunity in a murine model of lung carcinoma</a></div><div class="wp-workCard_item"><span>Immunology Letters</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to pro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cells receiving radiation often produce the &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;danger signal&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; cytokines such as TNF-alpha and IL-1. Another cytokine MIP-3alpha that is able to attract DC to the tumor site is normally not secreted. We hypothesize that if artificial introduction of a large number of DC to the necrotic tumor site after radiation therapy by transfecting any cells at the tumor site to secrete DC-tropic MIP-3alpha, an anti-tumor immune response would be initiated. C57BL/6J mice bearing a well-known Lewis lung carcinoma are used to assess efficacy of this modality. The plasmid DNA containing pcDNA3.1/MIP-3alpha was injected into the subcutaneous tumors after radiation treatment. We demonstrate a detectable local expression of MIP-3alpha and local accumulation of DC. Tumor infiltrating lymphocytes after the treatment are predominantly CD8+ T-cells with rare CD4+ T-cells. The anti-tumor immune response was also measurable, which contributes at least in part to the finding that the treated mice have smaller tumor and prolonged survival, comparing to the control groups. This study suggests a potential new means of immune modulation and provides us a new concept of immunotherapy of cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458010"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458010"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458010; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458010]").text(description); $(".js-view-count[data-work-id=55458010]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458010; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458010']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458010, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55458010]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458010,"title":"Administration of MIP-3α gene to the tumor following radiation therapy boosts anti-tumor immunity in a murine model of lung carcinoma","translated_title":"","metadata":{"abstract":"Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cells receiving radiation often produce the \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;danger signal\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; cytokines such as TNF-alpha and IL-1. Another cytokine MIP-3alpha that is able to attract DC to the tumor site is normally not secreted. We hypothesize that if artificial introduction of a large number of DC to the necrotic tumor site after radiation therapy by transfecting any cells at the tumor site to secrete DC-tropic MIP-3alpha, an anti-tumor immune response would be initiated. C57BL/6J mice bearing a well-known Lewis lung carcinoma are used to assess efficacy of this modality. The plasmid DNA containing pcDNA3.1/MIP-3alpha was injected into the subcutaneous tumors after radiation treatment. We demonstrate a detectable local expression of MIP-3alpha and local accumulation of DC. Tumor infiltrating lymphocytes after the treatment are predominantly CD8+ T-cells with rare CD4+ T-cells. The anti-tumor immune response was also measurable, which contributes at least in part to the finding that the treated mice have smaller tumor and prolonged survival, comparing to the control groups. This study suggests a potential new means of immune modulation and provides us a new concept of immunotherapy of cancer.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Immunology Letters"},"translated_abstract":"Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cells receiving radiation often produce the \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;danger signal\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; cytokines such as TNF-alpha and IL-1. Another cytokine MIP-3alpha that is able to attract DC to the tumor site is normally not secreted. We hypothesize that if artificial introduction of a large number of DC to the necrotic tumor site after radiation therapy by transfecting any cells at the tumor site to secrete DC-tropic MIP-3alpha, an anti-tumor immune response would be initiated. C57BL/6J mice bearing a well-known Lewis lung carcinoma are used to assess efficacy of this modality. The plasmid DNA containing pcDNA3.1/MIP-3alpha was injected into the subcutaneous tumors after radiation treatment. We demonstrate a detectable local expression of MIP-3alpha and local accumulation of DC. Tumor infiltrating lymphocytes after the treatment are predominantly CD8+ T-cells with rare CD4+ T-cells. The anti-tumor immune response was also measurable, which contributes at least in part to the finding that the treated mice have smaller tumor and prolonged survival, comparing to the control groups. This study suggests a potential new means of immune modulation and provides us a new concept of immunotherapy of cancer.","internal_url":"https://www.academia.edu/55458010/Administration_of_MIP_3%CE%B1_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma","translated_internal_url":"","created_at":"2021-10-04T08:58:25.584-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Administration_of_MIP_3α_gene_to_the_tumor_following_radiation_therapy_boosts_anti_tumor_immunity_in_a_murine_model_of_lung_carcinoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7864,"name":"Gene Therapy","url":"https://www.academia.edu/Documents/in/Gene_Therapy"},{"id":10030,"name":"Radiation Therapy","url":"https://www.academia.edu/Documents/in/Radiation_Therapy"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":135250,"name":"Antigen Presentation","url":"https://www.academia.edu/Documents/in/Antigen_Presentation"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":183861,"name":"Immune modulation","url":"https://www.academia.edu/Documents/in/Immune_modulation"},{"id":190363,"name":"Plasmids","url":"https://www.academia.edu/Documents/in/Plasmids"},{"id":431152,"name":"CTL","url":"https://www.academia.edu/Documents/in/CTL"},{"id":951639,"name":"Murine Model","url":"https://www.academia.edu/Documents/in/Murine_Model"},{"id":1238057,"name":"PBMC","url":"https://www.academia.edu/Documents/in/PBMC"},{"id":1320136,"name":"Plasmid DNA","url":"https://www.academia.edu/Documents/in/Plasmid_DNA"},{"id":1554614,"name":"Lung Carcinoma","url":"https://www.academia.edu/Documents/in/Lung_Carcinoma"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group"},{"id":3061075,"name":"Genetic Therapy","url":"https://www.academia.edu/Documents/in/Genetic_Therapy"},{"id":3608309,"name":"tumor immunity","url":"https://www.academia.edu/Documents/in/tumor_immunity"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458008"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458008/CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice"><img alt="Research paper thumbnail of CD80, but not CD86 were up-regulated on the spleen-derived dendritic cells from OVA-sensitized and challenged BALB/c mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458008/CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice">CD80, but not CD86 were up-regulated on the spleen-derived dendritic cells from OVA-sensitized and challenged BALB/c mice</a></div><div class="wp-workCard_item"><span>Immunology Letters</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of allergic asthma. It is well established that T cells activation requires interaction of T cell receptor (TCR) and MHC-peptide complex, as well as costimulatory signal delivered by antigen presenting cells (APCs). There is increasing evidence that CD80 (B7.1) and CD86 (B7.2), as the most important costimulatory molecules, are involved in the allergic immune responses. In the present study, we investigated the CD80 and CD86 expression of spleen-derived dendritic cells (DCs) in a murine model of allergic asthma. We first established a murine model of ovalbumin (OVA)-allergic asthma that showed unique histological characteristic of allergic inflammation in the lung, high serum OVA-specific IgE level, high numbers of eosinophils in the bronchoalveolar lavage (BAL) and high production of Type 2 cytokines in the splenic T cells. In this model, we found that CD80 were significantly upregulated on the spleen-derived DCs from OVA-sensitized and challenged mice compared with that from PBS-treated or non-treated mice, while CD86 is not different among three groups. Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice. Our results suggest that DCs in the spleen of allergic mice, via upregulation of CD80 might play a pivotal role in the maintenance and amplification of allergic immune response, namely Th2 immune response.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458008"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458008"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458008; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458008]").text(description); $(".js-view-count[data-work-id=55458008]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458008; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458008']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458008, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55458008]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458008,"title":"CD80, but not CD86 were up-regulated on the spleen-derived dendritic cells from OVA-sensitized and challenged BALB/c mice","translated_title":"","metadata":{"abstract":"Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of allergic asthma. It is well established that T cells activation requires interaction of T cell receptor (TCR) and MHC-peptide complex, as well as costimulatory signal delivered by antigen presenting cells (APCs). There is increasing evidence that CD80 (B7.1) and CD86 (B7.2), as the most important costimulatory molecules, are involved in the allergic immune responses. In the present study, we investigated the CD80 and CD86 expression of spleen-derived dendritic cells (DCs) in a murine model of allergic asthma. We first established a murine model of ovalbumin (OVA)-allergic asthma that showed unique histological characteristic of allergic inflammation in the lung, high serum OVA-specific IgE level, high numbers of eosinophils in the bronchoalveolar lavage (BAL) and high production of Type 2 cytokines in the splenic T cells. In this model, we found that CD80 were significantly upregulated on the spleen-derived DCs from OVA-sensitized and challenged mice compared with that from PBS-treated or non-treated mice, while CD86 is not different among three groups. Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice. Our results suggest that DCs in the spleen of allergic mice, via upregulation of CD80 might play a pivotal role in the maintenance and amplification of allergic immune response, namely Th2 immune response.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Immunology Letters"},"translated_abstract":"Allergen-specific CD4+ T-helper (Th) 2 cells are involved in the induction and effector phase of allergic asthma. It is well established that T cells activation requires interaction of T cell receptor (TCR) and MHC-peptide complex, as well as costimulatory signal delivered by antigen presenting cells (APCs). There is increasing evidence that CD80 (B7.1) and CD86 (B7.2), as the most important costimulatory molecules, are involved in the allergic immune responses. In the present study, we investigated the CD80 and CD86 expression of spleen-derived dendritic cells (DCs) in a murine model of allergic asthma. We first established a murine model of ovalbumin (OVA)-allergic asthma that showed unique histological characteristic of allergic inflammation in the lung, high serum OVA-specific IgE level, high numbers of eosinophils in the bronchoalveolar lavage (BAL) and high production of Type 2 cytokines in the splenic T cells. In this model, we found that CD80 were significantly upregulated on the spleen-derived DCs from OVA-sensitized and challenged mice compared with that from PBS-treated or non-treated mice, while CD86 is not different among three groups. Furthermore, we demonstrated that Th2 immune responses were elicited by these DCs with high expression of CD80, even to nai;ve T cells from non-treated mice. Our results suggest that DCs in the spleen of allergic mice, via upregulation of CD80 might play a pivotal role in the maintenance and amplification of allergic immune response, namely Th2 immune response.","internal_url":"https://www.academia.edu/55458008/CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice","translated_internal_url":"","created_at":"2021-10-04T08:58:25.505-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"CD80_but_not_CD86_were_up_regulated_on_the_spleen_derived_dendritic_cells_from_OVA_sensitized_and_challenged_BALB_c_mice","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma"},{"id":20212,"name":"Allergic asthma","url":"https://www.academia.edu/Documents/in/Allergic_asthma"},{"id":34021,"name":"T cell receptor","url":"https://www.academia.edu/Documents/in/T_cell_receptor"},{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells"},{"id":49018,"name":"Spleen","url":"https://www.academia.edu/Documents/in/Spleen"},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":273338,"name":"IL","url":"https://www.academia.edu/Documents/in/IL"},{"id":662855,"name":"T cell activation","url":"https://www.academia.edu/Documents/in/T_cell_activation"},{"id":951639,"name":"Murine Model","url":"https://www.academia.edu/Documents/in/Murine_Model"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay"},{"id":2005397,"name":"Bronchoalveolar lavage","url":"https://www.academia.edu/Documents/in/Bronchoalveolar_lavage"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458007"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458007/Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice"><img alt="Research paper thumbnail of Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/71318131/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458007/Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice">Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice</a></div><div class="wp-workCard_item"><span>Genetic Vaccines and Therapy</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e933191b73a813b4911f333fdcde8d70" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318131,"asset_id":55458007,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318131/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458007"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458007"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458007; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458007]").text(description); $(".js-view-count[data-work-id=55458007]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458007; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458007']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458007, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e933191b73a813b4911f333fdcde8d70" } } $('.js-work-strip[data-work-id=55458007]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458007,"title":"Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice","translated_title":"","metadata":{"publisher":"Springer Nature","grobid_abstract":"Background: Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2 cells plays a decisive role in the development of immune response against allergens. Objective: To evaluate effects and potential mechanisms of DNA vaccine containing ovalbumin (OVA) and Fc fusion on allergic airway inflammation. Methods: Bronchoalveolar lavage (BAL) levels of inflammatory mediators and leukocyte infiltration, expression of CD 11c + CD 80 + and CD 11c + CD 86 + co-stimulatory molecules in spleen dendritic cells (DCs), circulating CD 4 + and CD 8 + T cells, Foxp3 + in spleen CD 4 + T cells and spleen CD 4 + T cells were measured in OVA-sensitized and challenged animals pretreated with pcDNA, OVA-pcDNA, Fc-pcDNA, and OVA-Fc-pcDNA. Results: OVA-Sensitized and challenged mice developed airway inflammation and Th2 responses, and decreased the proliferation of peripheral CD 4 + and CD 8 + T cells and the number of spleen Foxp 3 + Treg. Those changes with increased INF-γ production and reduced OVA-specific IgE production were protected by the pretreatment with OVA-Fc-pcDNA. Conclusion: DNA vaccine encoding both Fc and OVA showed more effective than DNA vaccine encoding Fc or OVA alone, through the balance of DCs and Treg.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Genetic Vaccines and Therapy","grobid_abstract_attachment_id":71318131},"translated_abstract":null,"internal_url":"https://www.academia.edu/55458007/Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice","translated_internal_url":"","created_at":"2021-10-04T08:58:25.421-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71318131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318131/thumbnails/1.jpg","file_name":"pmc2861055.pdf","download_url":"https://www.academia.edu/attachments/71318131/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protection_against_the_allergic_airway_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318131/pmc2861055-libre.pdf?1633364842=\u0026response-content-disposition=attachment%3B+filename%3DProtection_against_the_allergic_airway_i.pdf\u0026Expires=1732742021\u0026Signature=XXSmVPszxD2R-~~tixWmXOnkgKZc6Rvc4QZ2Hv~MjQTrAbSF620atAp6FQOb3PVraPnqracr5uJvasEnylN3rL6ni9mnoy5xPe-x3NuGDtGj-PKNzukUn9QVY6EvBB2aAyxdGjyWjUQ9NSfh8DIIvarzd9nmoceau8qBcd52wGnhCPo9jGNG5ZxyeFrpewZct9RtJHuNV2Jh6ibDarxZCtwTqkbHA7DOZuuF3o9ytU-elxbFt9cAAVScuT1CnX2yXHgHkLiAnkDE4Dl1Rx3ZLyJw~I56bcjw1iQK6y7QWBjKJ2ttrpOAM5-pyDtgZKKkBL4pehx4JWtJK602~AcL-A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":71318131,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318131/thumbnails/1.jpg","file_name":"pmc2861055.pdf","download_url":"https://www.academia.edu/attachments/71318131/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Protection_against_the_allergic_airway_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318131/pmc2861055-libre.pdf?1633364842=\u0026response-content-disposition=attachment%3B+filename%3DProtection_against_the_allergic_airway_i.pdf\u0026Expires=1732742021\u0026Signature=XXSmVPszxD2R-~~tixWmXOnkgKZc6Rvc4QZ2Hv~MjQTrAbSF620atAp6FQOb3PVraPnqracr5uJvasEnylN3rL6ni9mnoy5xPe-x3NuGDtGj-PKNzukUn9QVY6EvBB2aAyxdGjyWjUQ9NSfh8DIIvarzd9nmoceau8qBcd52wGnhCPo9jGNG5ZxyeFrpewZct9RtJHuNV2Jh6ibDarxZCtwTqkbHA7DOZuuF3o9ytU-elxbFt9cAAVScuT1CnX2yXHgHkLiAnkDE4Dl1Rx3ZLyJw~I56bcjw1iQK6y7QWBjKJ2ttrpOAM5-pyDtgZKKkBL4pehx4JWtJK602~AcL-A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":664253,"name":"DNA vaccine","url":"https://www.academia.edu/Documents/in/DNA_vaccine"},{"id":2005397,"name":"Bronchoalveolar lavage","url":"https://www.academia.edu/Documents/in/Bronchoalveolar_lavage"},{"id":2188946,"name":"Airway Inflammation","url":"https://www.academia.edu/Documents/in/Airway_Inflammation"},{"id":2976793,"name":"Regulatory T cell","url":"https://www.academia.edu/Documents/in/Regulatory_T_cell"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458005"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458005/Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells"><img alt="Research paper thumbnail of Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458005/Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells">Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells</a></div><div class="wp-workCard_item"><span>Cancer Science</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation and cancer. Recently, we found that increased IL-17-producing cells correlate with poor survival and increased lymphangiogenesis in non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Here, we show that IL-17 promotes lymphangiogenesis via inducing vascular endothelial growth factor-C (VEGF-C) production by lung cancer cells. We found that IL-17 receptor (IL-17R) is expressed on the surface of Lewis lung carcinoma (LLC) cells but not on lymphatic endothelial cells (LEC). Moreover, LEC chemotaxis and tube formation (measures of net lymphangiogenic potential) were increased by conditioned medium from recombinant mouse IL-17 (rmIL-17)-stimulated LLC but not by rmIL-17. Interleukin-17 increased production of VEGF-C in lung cancer cell lines. The enhanced chemotaxis and endothelial cord formation in the presence of LLC/rmIL-17 was inhibited by addition of recombinant mouse VEGF R3/Fc chimera. Treatment of the A549 cells with rIL-17 significantly increased VEGF-C expression, which was extracellular signal-regulated protein kinase 1/2 (ERK 1/2) dependent. Importantly, we found significant correlations between IL-17 expression, VEGF-C expression and lymphatic vascular density (LVD) in NSCLC. We conclude that IL-17 is involved in lymphangiogenesis in NSCLC by enhancing production of VEGF-C, and IL-17 may be an important target for the treatment of NSCLC.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458005"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458005"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458005; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458005]").text(description); $(".js-view-count[data-work-id=55458005]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458005; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458005']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458005, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55458005]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55458005,"title":"Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells","translated_title":"","metadata":{"abstract":"Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation and cancer. Recently, we found that increased IL-17-producing cells correlate with poor survival and increased lymphangiogenesis in non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Here, we show that IL-17 promotes lymphangiogenesis via inducing vascular endothelial growth factor-C (VEGF-C) production by lung cancer cells. We found that IL-17 receptor (IL-17R) is expressed on the surface of Lewis lung carcinoma (LLC) cells but not on lymphatic endothelial cells (LEC). Moreover, LEC chemotaxis and tube formation (measures of net lymphangiogenic potential) were increased by conditioned medium from recombinant mouse IL-17 (rmIL-17)-stimulated LLC but not by rmIL-17. Interleukin-17 increased production of VEGF-C in lung cancer cell lines. The enhanced chemotaxis and endothelial cord formation in the presence of LLC/rmIL-17 was inhibited by addition of recombinant mouse VEGF R3/Fc chimera. Treatment of the A549 cells with rIL-17 significantly increased VEGF-C expression, which was extracellular signal-regulated protein kinase 1/2 (ERK 1/2) dependent. Importantly, we found significant correlations between IL-17 expression, VEGF-C expression and lymphatic vascular density (LVD) in NSCLC. We conclude that IL-17 is involved in lymphangiogenesis in NSCLC by enhancing production of VEGF-C, and IL-17 may be an important target for the treatment of NSCLC.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Cancer Science"},"translated_abstract":"Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation and cancer. Recently, we found that increased IL-17-producing cells correlate with poor survival and increased lymphangiogenesis in non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Here, we show that IL-17 promotes lymphangiogenesis via inducing vascular endothelial growth factor-C (VEGF-C) production by lung cancer cells. We found that IL-17 receptor (IL-17R) is expressed on the surface of Lewis lung carcinoma (LLC) cells but not on lymphatic endothelial cells (LEC). Moreover, LEC chemotaxis and tube formation (measures of net lymphangiogenic potential) were increased by conditioned medium from recombinant mouse IL-17 (rmIL-17)-stimulated LLC but not by rmIL-17. Interleukin-17 increased production of VEGF-C in lung cancer cell lines. The enhanced chemotaxis and endothelial cord formation in the presence of LLC/rmIL-17 was inhibited by addition of recombinant mouse VEGF R3/Fc chimera. Treatment of the A549 cells with rIL-17 significantly increased VEGF-C expression, which was extracellular signal-regulated protein kinase 1/2 (ERK 1/2) dependent. Importantly, we found significant correlations between IL-17 expression, VEGF-C expression and lymphatic vascular density (LVD) in NSCLC. We conclude that IL-17 is involved in lymphangiogenesis in NSCLC by enhancing production of VEGF-C, and IL-17 may be an important target for the treatment of NSCLC.","internal_url":"https://www.academia.edu/55458005/Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells","translated_internal_url":"","created_at":"2021-10-04T08:58:25.335-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Role_of_interleukin_17_in_lymphangiogenesis_in_non_small_cell_lung_cancer_Enhanced_production_of_vascular_endothelial_growth_factor_C_in_non_small_cell_lung_carcinoma_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":32722,"name":"Lymphangiogenesis","url":"https://www.academia.edu/Documents/in/Lymphangiogenesis"},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":170276,"name":"Chemotaxis","url":"https://www.academia.edu/Documents/in/Chemotaxis"},{"id":213910,"name":"Mitogen Activated Protein Kinase","url":"https://www.academia.edu/Documents/in/Mitogen_Activated_Protein_Kinase"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins"},{"id":1166930,"name":"Cytoplasm","url":"https://www.academia.edu/Documents/in/Cytoplasm"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":3067128,"name":"reverse transcriptase polymerase chain reaction","url":"https://www.academia.edu/Documents/in/reverse_transcriptase_polymerase_chain_reaction"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55458003"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55458003/IL_17_is_associated_with_poor_prognosis_and_promotes_angiogenesis_via_stimulating_VEGF_production_of_cancer_cells_in_colorectal_carcinoma"><img alt="Research paper thumbnail of IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma" class="work-thumbnail" src="https://attachments.academia-assets.com/71318139/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55458003/IL_17_is_associated_with_poor_prognosis_and_promotes_angiogenesis_via_stimulating_VEGF_production_of_cancer_cells_in_colorectal_carcinoma">IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma</a></div><div class="wp-workCard_item"><span>Biochemical and Biophysical Research Communications</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="24d45d836064d1c2a987980595047692" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71318139,"asset_id":55458003,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71318139/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55458003"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55458003"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55458003; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55458003]").text(description); $(".js-view-count[data-work-id=55458003]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55458003; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55458003']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55458003, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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However, the characteristics of IL-17-producing cells, the relevance of IL-17 to clinical parameters and its function in the development and progression of colorectal carcinoma still remain to be explored. In the present study, we first found the levels of IL-17 producing cells were significantly increased in the tumor regions of samples from colorectal carcinoma patients compared with non-tumor regions. Confocal microscopic analysis showed co-staining of IL-17 with CD4 and CD68, indicating IL-17 in colorectal carcinoma was expressed by macrophage and Th17. High expression of IL-17 was associated with high microvessel density. Univariate and multivariate analysis revealed that IL-17 was an independent prognostic factor for overall survival. To explore the underlying mechanisms of IL-17 in angiogenesis, we used PCR-array to find pro-angiogenic factor in cancer cells specifically induced by IL-17, then validated VEGF as one of factors in IL-17-mediated angiogenesis with the use of quantitative RT-PCR, ELISA and VEGF immunohistochemistry. Our results propose IL-17 as a novel indicator of prognosis in the patients with colorectal carcinoma and could serve as a novel therapeutic target for colorectal carcinoma, furthermore our results indicate that IL-17 producing cells may facilitate development of colorectal carcinoma by fostering angiogenesis via promote VEGF production from cancer cells.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Biochemical and Biophysical Research Communications","grobid_abstract_attachment_id":71318139},"translated_abstract":null,"internal_url":"https://www.academia.edu/55458003/IL_17_is_associated_with_poor_prognosis_and_promotes_angiogenesis_via_stimulating_VEGF_production_of_cancer_cells_in_colorectal_carcinoma","translated_internal_url":"","created_at":"2021-10-04T08:58:25.233-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":71318139,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318139/thumbnails/1.jpg","file_name":"j.bbrc.2011.03.02120211004-14905-f8266h.pdf","download_url":"https://www.academia.edu/attachments/71318139/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IL_17_is_associated_with_poor_prognosis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318139/j.bbrc.2011.03.02120211004-14905-f8266h-libre.pdf?1633364840=\u0026response-content-disposition=attachment%3B+filename%3DIL_17_is_associated_with_poor_prognosis.pdf\u0026Expires=1732742021\u0026Signature=VugdZAAL~wY0RkgY947iMtJh56ByWBiZgzWCKRiTsSBDw7sNu0VWF7LWagnbvni5ieePkTUxAifkDe366XuApIAxydscmGXDnxUwQRMYw1ve7Of16~rBT92LxrDXx2Lxga8j3si9jNDm9HKo7godptqeMX5tZeVPXqlPJJkw7fbzkdgkbStcSsZ3qL4HOEEt3qRBmxsDzK83Zh7DF7ti0rogXNUulZ0mbIg1EQF2dya3dgrLVenwQR3v0wLfj2nKtHudgYEmnOgu14kuYPvUsGgLMeBwJwDDWw12CUFtFHpyAUaSitLTByC4YUZ7kqAyBgcWWV-l42ZL-5fuG1eqAA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"IL_17_is_associated_with_poor_prognosis_and_promotes_angiogenesis_via_stimulating_VEGF_production_of_cancer_cells_in_colorectal_carcinoma","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[{"id":71318139,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/71318139/thumbnails/1.jpg","file_name":"j.bbrc.2011.03.02120211004-14905-f8266h.pdf","download_url":"https://www.academia.edu/attachments/71318139/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"IL_17_is_associated_with_poor_prognosis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/71318139/j.bbrc.2011.03.02120211004-14905-f8266h-libre.pdf?1633364840=\u0026response-content-disposition=attachment%3B+filename%3DIL_17_is_associated_with_poor_prognosis.pdf\u0026Expires=1732742021\u0026Signature=VugdZAAL~wY0RkgY947iMtJh56ByWBiZgzWCKRiTsSBDw7sNu0VWF7LWagnbvni5ieePkTUxAifkDe366XuApIAxydscmGXDnxUwQRMYw1ve7Of16~rBT92LxrDXx2Lxga8j3si9jNDm9HKo7godptqeMX5tZeVPXqlPJJkw7fbzkdgkbStcSsZ3qL4HOEEt3qRBmxsDzK83Zh7DF7ti0rogXNUulZ0mbIg1EQF2dya3dgrLVenwQR3v0wLfj2nKtHudgYEmnOgu14kuYPvUsGgLMeBwJwDDWw12CUFtFHpyAUaSitLTByC4YUZ7kqAyBgcWWV-l42ZL-5fuG1eqAA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":41482,"name":"Multivariate 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RT-PCR","url":"https://www.academia.edu/Documents/in/quantitative_RT-PCR"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55457996"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/55457996/Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice"><img alt="Research paper thumbnail of Roles of costimulatory molecules in pulmonary dendritic cells in the development of asthma in mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/55457996/Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice">Roles of costimulatory molecules in pulmonary dendritic cells in the development of asthma in mice</a></div><div class="wp-workCard_item"><span>Chinese Journal of Lung Diseases (Electronic Version)</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducing and modulating immune responses in a murine asthma model. Methods Murine asthma model, established with ovalbumin (OVA) sensitization and challenge, was confirmed by histological analysis of the lung tissues, cell count and differentiation of bronchoalveolar lavage fluid (BALF), serum OVA-specific IgE level, and the levels of IL-4, IL-5 and IFN-g in BALF by ELISA. The purity of pulmonary dendritic cells was assayed with ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55457996"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55457996"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55457996; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55457996]").text(description); $(".js-view-count[data-work-id=55457996]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55457996; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='55457996']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 55457996, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=55457996]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":55457996,"title":"Roles of costimulatory molecules in pulmonary dendritic cells in the development of asthma in mice","translated_title":"","metadata":{"abstract":"Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducing and modulating immune responses in a murine asthma model. Methods Murine asthma model, established with ovalbumin (OVA) sensitization and challenge, was confirmed by histological analysis of the lung tissues, cell count and differentiation of bronchoalveolar lavage fluid (BALF), serum OVA-specific IgE level, and the levels of IL-4, IL-5 and IFN-g in BALF by ELISA. The purity of pulmonary dendritic cells was assayed with ...","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Chinese Journal of Lung Diseases (Electronic Version)"},"translated_abstract":"Objective To explore the roles of costimulatory molecules in pulmonary dendritic cells in inducing and modulating immune responses in a murine asthma model. Methods Murine asthma model, established with ovalbumin (OVA) sensitization and challenge, was confirmed by histological analysis of the lung tissues, cell count and differentiation of bronchoalveolar lavage fluid (BALF), serum OVA-specific IgE level, and the levels of IL-4, IL-5 and IFN-g in BALF by ELISA. The purity of pulmonary dendritic cells was assayed with ...","internal_url":"https://www.academia.edu/55457996/Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice","translated_internal_url":"","created_at":"2021-10-04T08:58:24.655-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":50079491,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Roles_of_costimulatory_molecules_in_pulmonary_dendritic_cells_in_the_development_of_asthma_in_mice","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":50079491,"first_name":"xiaoming","middle_initials":null,"last_name":"cheng","page_name":"xiaomingcheng","domain_name":"independent","created_at":"2016-06-15T03:38:24.909-07:00","display_name":"xiaoming cheng","url":"https://independent.academia.edu/xiaomingcheng"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55457991"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55457991/Research_Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice"><img alt="Research paper thumbnail of Research Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/71318050/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55457991/Research_Protection_against_the_allergic_airway_inflammation_depends_on_the_modulation_of_spleen_dendritic_cell_function_and_induction_of_regulatory_T_cells_in_mice">Research Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BioMedCentral © 2010 Wang et al; licensee BioMed Central Ltd. This is an Open Access article dist...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BioMedCentral © 2010 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<a href="http://creativecommons.org/licenses/by/2.0" rel="nofollow">http://creativecommons.org/licenses/by/2.0</a>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ... Research Protection against the allergic airway inflammation ... 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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ... Research Protection against the allergic airway inflammation ... Yaoli Wang1,2,3, Chunxue Bai2, Guansong Wang1, Diane Wang, Xiaoming Cheng1, Jian Huang, Dongpo Jiang, Guisheng Qian1 ...","publication_date":{"day":null,"month":null,"year":2010,"errors":{}}},"translated_abstract":"BioMedCentral © 2010 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ... Research Protection against the allergic airway inflammation ... 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="55452403"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/55452403/Chinese_expert_consensus_based_guideline_on_assessment_and_management_of_asthma_exacerbation"><img alt="Research paper thumbnail of Chinese expert consensus-based guideline on assessment and management of asthma exacerbation" class="work-thumbnail" src="https://attachments.academia-assets.com/71315100/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/55452403/Chinese_expert_consensus_based_guideline_on_assessment_and_management_of_asthma_exacerbation">Chinese expert consensus-based guideline on assessment and management of asthma exacerbation</a></div><div class="wp-workCard_item"><span>Journal of Thoracic Disease</span><span>, Dec 1, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c5243556ebf0a4b9fec3dab815a47ca8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":71315100,"asset_id":55452403,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/71315100/download_file?st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&st=MTczMjczODQyMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="55452403"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="55452403"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55452403; 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Asthma exacerbation as one of critical component of the future risks (1,2), may induce a variety of harms to the host, necessitate additional use of medical resources, impose serious socioeconomic burdens, and represent a significant cause of asthma-related disability and mortality (3). As such, prevention and reduction of the asthma exacerbation are of important relevance in improving the overall control of asthma (2-5). In diagnosing and treating asthma exacerbation, the expertise of clinicians in Chinese hospitals of varied levels has currently been compromised by less standard practicing due to a number of subjective or objective factors. This also results in increased medical cost (3). To standardize the practicing, renew the understandings on diagnosis and treatment, and improve the care for asthma exacerbation, the China Asthma Alliance (CAA) has developed this consensus document based on in-depth discussion among a summoned panel of Chinese experts in related fields, with reference to relevant international guidelines (1,6,7) and focused articles appearing within and outside the country in the past few years. The document is desired to offer guidance and evidence for diagnosis, treatment, prevention and management of asthma exacerbation in clinical settings, as well as related studies. Definition Asthma exacerbation is defined as sudden onset of symptoms like wheezing, shortness of breath, cough and chest tightness, or worsening of the current symptoms, typically associated with dyspnea and characterized by reduced expiratory flow, and usually requires adjustment of medications (1,6,7). Although sometimes it can be an initial manifestation, asthma exacerbation more likely occurs in patients with confirmed asthma, and in most of times, is triggered by exposure to allergens or irritants, respiratory infections or poor patient adherence to controller medications (5,7), despite unclear predisposing factors in fewer patients. 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