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(PDF) Creutzfeldt-Jakob Disease: Four Case Reports
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window.loswp.work = {"work":{"id":72709287,"created_at":"2022-03-01T12:32:11.202-08:00","from_world_paper_id":197236602,"updated_at":"2025-02-01T23:11:14.353-08:00","_data":{"publisher":"Federation of Turkish Pathology Societies","ai_title_tag":"Creutzfeldt-Jakob Disease: Four Case Reports","grobid_abstract":"Creutzfeldt-Jakob disease is a very rare, progressive neurodegenerative disorder that is incurable and always fatal. It is one of the transmissible spongiform encephalopathies caused by prions. Multiple vacuoles in neuropil and neuronal loss in the gray matter gives the classical sponge-like appearance of brain and are responsible for the typical clinical symptoms. In this report, we present 4 cases referred to the neurology department of Uludağ University with neurological symptoms. Patients were evaluated with electroencephalogram and magnetic resonance imaging, and performed brain biopsies for further investigation. For definitive diagnosis of Creutzfeldt-Jakob disease, accumulation of prion protein in brain was detected immunohistochemically. Patients died within weeks in consequence of rapid progression of the disease. Although Creutzfeldt-Jakob disease is an infrequent disorder, when a patient presents with characteristic clinical symptoms such as rapidly progressive dementia with myoclonus, the diagnosis of Creutzfeldt-Jakob disease should be taken into consideration.","publication_date":"2013,,","publication_name":"Turkish Journal of Pathology","grobid_abstract_attachment_id":"81529830"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Creutzfeldt-jakob disease: report of four cases and review of the literature","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [25560578]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":81529830,"attachmentType":"pdf"}"><img alt="First page of “Creutzfeldt-jakob disease: report of four cases and review of the literature”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/81529830/mini_magick20220301-16036-yl2voz.png?1646166895" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Creutzfeldt-jakob disease: report of four cases and review of the literature</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="25560578" href="https://independent.academia.edu/mehmetzarifo%C4%9Flu"><img alt="Profile image of mehmet zarifoğlu" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />mehmet zarifoğlu</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2013, Turkish Journal of Pathology</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">5 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 72709287; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Creutzfeldt-Jakob disease is a very rare, progressive neurodegenerative disorder that is incurable and always fatal. It is one of the transmissible spongiform encephalopathies caused by prions. Multiple vacuoles in neuropil and neuronal loss in the gray matter gives the classical sponge-like appearance of brain and are responsible for the typical clinical symptoms. In this report, we present 4 cases referred to the neurology department of Uludağ University with neurological symptoms. Patients were evaluated with electroencephalogram and magnetic resonance imaging, and performed brain biopsies for further investigation. For definitive diagnosis of Creutzfeldt-Jakob disease, accumulation of prion protein in brain was detected immunohistochemically. Patients died within weeks in consequence of rapid progression of the disease. Although Creutzfeldt-Jakob disease is an infrequent disorder, when a patient presents with characteristic clinical symptoms such as rapidly progressive dementia with myoclonus, the diagnosis of Creutzfeldt-Jakob disease should be taken into consideration.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":81529830,"attachmentType":"pdf","workUrl":"https://www.academia.edu/72709287/Creutzfeldt_jakob_disease_report_of_four_cases_and_review_of_the_literature"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":81529830,"attachmentType":"pdf","workUrl":"https://www.academia.edu/72709287/Creutzfeldt_jakob_disease_report_of_four_cases_and_review_of_the_literature"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Prions replicate in lymphoreticular tissues before neuroinvasion, suggesting that lymphoreticular biopsy samples may allow early diagnosis by detection of PrP Sc. Creutzfeldt-Jakob Disease (CJD) is the most frequent prion disease in humans. Clinical diagnosis of sporadic (CJD) is based on the evaluation of rapidly progressive dementia, ataxia, myoclonus, changes on the electroencephalogram and other neurological signs. We report a problable (CJD) case in Santa Barbara surgical center, Rio de Janeiro, Brazil. From our clinical case, we decided to do a brief review about (CJD) researching at Medline and Pubmed, using terms Creutzfeldt-Jakob disease and Prion diseases. A definite diagnosis, however, is confined to cases that have been evaluated neuropathlogically or by equivalent diagnostic techniques. The range in clinical expression of the disease is better appreciated and the existence of "atypical" cases of CJD is increasingly recognized. The clinical characteristics, laboratory findings, differential diagnosis, mechanisms of transmission and the actual therapeutic approach are discussed.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Probable Creutzfeldt Jakob Disease: Case Report","attachmentId":73425950,"attachmentType":"pdf","work_url":"https://www.academia.edu/59571432/Probable_Creutzfeldt_Jakob_Disease_Case_Report","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/59571432/Probable_Creutzfeldt_Jakob_Disease_Case_Report"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="17280513" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17280513/Creutzfeldt_Jakob_disease_case_report_and_review_of_the_literature">Creutzfeldt-Jakob disease: case report and review of the literature</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36930154" href="https://independent.academia.edu/MartinaSpero">Martina Spero</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta clinica Croatica, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Creutzfeldt-Jakob disease (CJD) is a rare, fatal neurodegenerative disease caused by an infectious protein called prion and is characterized by spongiform changes, neuronal loss, reactive astrocytic proliferation and accumulation of pathologic cellular protein, occurring in 3 general forms: sporadic or spontaneous, genetic or familial, and acquired form including a variant form of CJD. Clinical presentation of CJD is characterized by progressive dementia, neurologic symptoms and visual impairment, development of akinetic mutism, and eventually death, usually from respiratory infection. The diagnosis is based on clinical presentation, electroencephalogram, and typical cerebrospinal fluid and magnetic resonance imaging findings. A case is presented of a 56-year-old woman with progressive dementia, typical neurologic symptoms, positive cerebrospinal fluid and typical magnetic resonance imaging findings. The clinical, pathologic and imaging findings of this rare condition are also discu...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Creutzfeldt-Jakob disease: case report and review of the literature","attachmentId":42272508,"attachmentType":"pdf","work_url":"https://www.academia.edu/17280513/Creutzfeldt_Jakob_disease_case_report_and_review_of_the_literature","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17280513/Creutzfeldt_Jakob_disease_case_report_and_review_of_the_literature"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="81930812" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81930812/Diagnosis_and_Incidence_of_Prion_Creutzfeldt_Jakob_Disease_A_Retrospective_Archival_Survey_with_Implications_for_Future_Research">Diagnosis and Incidence of Prion (Creutzfeldt-Jakob) Disease: A Retrospective Archival Survey with Implications for Future Research</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47927485" href="https://independent.academia.edu/StephenGentleman">Stephen Gentleman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurodegeneration, 1995</p><p class="ds-related-work--abstract ds2-5-body-sm">THE TERM PRION DISEASE includes the human disorders Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker disease (GSS), Kuru, fatal familial insomnia and familial atypical dementia along with similar disorders in sheep (scrapie), cattle (BSE), goats, cats and other species (Prusiner et al., 1992). These conditions are subacute, progressive, transmissible and uniformly fatal degenerative diseases of the central nervous system. They have also been known as 'subacute spongiform encephalopathies', 'slow virus infections', 'transmissible dementias' and 'transmissible amyloidoses', all names which signify successive attempts to identify their cardinal features (Nevin et al., 1960; Corsellis, 1976; Prusiner, 1987; Gajdusek, 1991). The central link between all prion diseases is thought to be the presence of an abnormalprotease resistant-isoform (PrP sc) of the normal prion protein (PrPc) expressed by most neurons in the central nervous system (Prusiner et al.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Diagnosis and Incidence of Prion (Creutzfeldt-Jakob) Disease: A Retrospective Archival Survey with Implications for Future Research","attachmentId":87802143,"attachmentType":"pdf","work_url":"https://www.academia.edu/81930812/Diagnosis_and_Incidence_of_Prion_Creutzfeldt_Jakob_Disease_A_Retrospective_Archival_Survey_with_Implications_for_Future_Research","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/81930812/Diagnosis_and_Incidence_of_Prion_Creutzfeldt_Jakob_Disease_A_Retrospective_Archival_Survey_with_Implications_for_Future_Research"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="58972084" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/58972084/Retrospective_study_of_Creutzfeldt_Jakob_disease_in_Belgium_neuropathological_findings">Retrospective study of Creutzfeldt-Jakob disease in Belgium: neuropathological findings</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58259992" href="https://independent.academia.edu/CatherineGodfraind">Catherine Godfraind</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Neuropathologica, 2000</p><p class="ds-related-work--abstract ds2-5-body-sm">Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy that affects about 1 in 10 6 inhabitants in most countries. Recently, a new variant of CJD has been linked to the epidemic of bovine spongiform encephalopathy. Therefore, vigilance concerning the disease's incidence has been increased. We conducted a comprehensive, nationwide and retrospective study. In 79 Belgian autopsies, we found the characteristic triad of spongiosis, neuronal loss and reactive gliosis. The occipital cortex was most affected, while the cerebellum was mostly spared. Immunohistochemistry was performed using hydrated autoclave pretreatment and several monoclonal antibodies directed against the prion protein. We identified prion-immunoreactive patterns and locations reflecting the important heterogeneity, independently of the antibody that was used. Granular prion immunoreactivity was observed in astrocytes. We studied the regional intensity of the prion immunostaining and determined that the frontal cortex with 95% positive immunoreactivity was best suited for a biopsy. We studied the disease duration in sporadic CJD patients who showed neuropathological lesions of other neurodegenerative disorders (such as Alzheimer's disease). The study shapes the framework in which a prospective neuropathological registry will be able to function.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Retrospective study of Creutzfeldt-Jakob disease in Belgium: neuropathological findings","attachmentId":73124202,"attachmentType":"pdf","work_url":"https://www.academia.edu/58972084/Retrospective_study_of_Creutzfeldt_Jakob_disease_in_Belgium_neuropathological_findings","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/58972084/Retrospective_study_of_Creutzfeldt_Jakob_disease_in_Belgium_neuropathological_findings"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="91661044" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/91661044/A_rare_case_of_sporadic_Creutzfeldt_Jakob_disease_in_an_83_years_old_female">A rare case of sporadic Creutzfeldt-Jakob disease in an 83 years old female</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="68472311" href="https://independent.academia.edu/ArjunBal">Arjun Bal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Advances in Medicine, 2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Sporadic Creutzfeldt-Jakob disease is a rare invariably fatal neurodegenerative prion disease. Prion disease are associated with the conversion of alpha-helix rich cellular prion protein (PrPC) into a beta-structure rich insoluble conformer scrapie isoform (PrPSc) thought to be infectious isoform. Here we present a case of an 83 years old woman with findings of rapidly progressive dementia, cognitive disturbance, myoclonic jerks and extrapyramidal signs (cogwheel rigidity). Following a series of clinical and diagnostic (diffusion-weighted magnetic resonance imaging (MRI) brain, electroencephalogram (EEG)) examination she was diagnosed with sporadic Creutzfeldt-Jakob disease based on Centers for disease control and prevention (CDC) criteria.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A rare case of sporadic Creutzfeldt-Jakob disease in an 83 years old female","attachmentId":94885592,"attachmentType":"pdf","work_url":"https://www.academia.edu/91661044/A_rare_case_of_sporadic_Creutzfeldt_Jakob_disease_in_an_83_years_old_female","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/91661044/A_rare_case_of_sporadic_Creutzfeldt_Jakob_disease_in_an_83_years_old_female"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="53809183" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53809183/Sporadic_Creutzfeldt_Jakob_disease_causing_a_2_years_slowly_progressive_isolated_dementia">Sporadic Creutzfeldt-Jakob disease causing a 2-years slowly progressive isolated dementia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="93561714" href="https://independent.academia.edu/AlvaroRa%C3%BAlMart%C3%ADnezSalgado">Alvaro Raúl Martínez Salgado</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Behavioural …, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">A 47-year-old woman was seen for progressive behavioural and cognitive disturbances slowly evolving over a 1-year period. Neuropsychological evaluation disclosed moderate to severe impairment of all cortical functions. Besides this no other clinical abnormality was found. MRI diffusion weighted imaging disclosed hyperintense cortical lesions in a ribbon-like fashion, with restricted diffusivity. EEG showed no periodic sharp waves and CSF examination was normal, including protein 14.3.3. She was heterozygote on codon 129. Her cognitive function continued to decline and she was readmitted for further investigation at the 24th month of disease. Again no ataxia or involuntary movements were observed. MRI disclosed widespread hyperintense lesions over the entire cortex and, for the first time, also caudato-putaminal hyperintensity in T2-weighted images. EEG again failed to show periodic activity. Stereotactic biopsy disclosed moderate spongiform changes, astrocytosis and perivacuolar staining with prion-directed antibodies. Western blot analysis revealed prion type 2 mobility pattern. We discuss the clinical significance of this case: as dementia was the sole finding, and this was slowly-evolving over a 2-year period, MRI findings were the key factor suggesting a prion disease in a woman that otherwise would probably be diagnosed with a primary degenerative dementia.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sporadic Creutzfeldt-Jakob disease causing a 2-years slowly progressive isolated dementia","attachmentId":70477064,"attachmentType":"pdf","work_url":"https://www.academia.edu/53809183/Sporadic_Creutzfeldt_Jakob_disease_causing_a_2_years_slowly_progressive_isolated_dementia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53809183/Sporadic_Creutzfeldt_Jakob_disease_causing_a_2_years_slowly_progressive_isolated_dementia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="80871097" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/80871097/_A_case_of_Creutzfeldt_Jakob_disease_with_a_point_mutation_of_prion_protein_at_codon_180_">[A case of Creutzfeldt-Jakob disease with a point mutation of prion protein at codon 180]</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37756281" href="https://independent.academia.edu/SusumuShirabe">Susumu Shirabe</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nō to shinkei = Brain and nerve, 2004</p><p class="ds-related-work--abstract ds2-5-body-sm">A 67-year-old woman was admitted to our hospital with progressive aphasia. There was no family history of similar diseases or any history of dura transplantation. Cranial magnetic resonance imaging (MRI) showed high signal areas in the temporal and parietal cortex predominantly on the left side on both T2-weighted images and on diffusion-weighted images. There were no periodic synchronous discharges observed on the electroencephalogram. As prion protein gene codon 180 point mutation (Val/Ile) was detected, we diagnosed her as having Creutzfeldt-Jakob disease (CJD). The characteristics of CJD of this type differ from those of sporadic CJD. To date, few papers on CJD with point mutation of codon 180 have been reported from Japan.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"[A case of Creutzfeldt-Jakob disease with a point mutation of prion protein at codon 180]","attachmentId":87108836,"attachmentType":"pdf","work_url":"https://www.academia.edu/80871097/_A_case_of_Creutzfeldt_Jakob_disease_with_a_point_mutation_of_prion_protein_at_codon_180_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/80871097/_A_case_of_Creutzfeldt_Jakob_disease_with_a_point_mutation_of_prion_protein_at_codon_180_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="96078693" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/96078693/Novel_Prion_Protein_Gene_Mutation_in_an_Octogenarian_With_Creutzfeldt_Jakob_Disease">Novel Prion Protein Gene Mutation in an Octogenarian With Creutzfeldt-Jakob Disease</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="255630071" href="https://independent.academia.edu/AshleyFletcher18">Ashley Fletcher</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Archives of Neurology, 2000</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: The transmissible spongiform encephalopathies constitute a fascinating and biologically unique group of invariably fatal neurodegenerative disorders that affect both animals and humans. Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia represent the more common human phenotypes. Excluding the small number of iatrogenically transmitted cases, approximately 85% to 90% of patients develop CJD without identifiable explanation, with an increasing number of different mutations in the prion protein gene (PRNP) recognized as probably causative in the remainder. Objective: To report on an 82-year-old woman with pathologically confirmed CJD found unexpectedly to harbor a novel mutation in PRNP. Methods: Routine clinical investigations were undertaken to elucidate the cause of the rapidly progressive dementia and neurological decline manifested by the patient, including magnetic resonance imaging of the brain, electroencephalography, and cerebrospinal fluid analysis for the 14-3-3  protein. Standard postmortem neuropathological examination of the brain was performed, including immunocytochemistry of representative sections to detect the prion protein. Posthumous genetic analysis of the open reading frame of PRNP was performed on frozen brain tissue using polymerase chain reaction and direct sequencing.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Novel Prion Protein Gene Mutation in an Octogenarian With Creutzfeldt-Jakob Disease","attachmentId":98077362,"attachmentType":"pdf","work_url":"https://www.academia.edu/96078693/Novel_Prion_Protein_Gene_Mutation_in_an_Octogenarian_With_Creutzfeldt_Jakob_Disease","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/96078693/Novel_Prion_Protein_Gene_Mutation_in_an_Octogenarian_With_Creutzfeldt_Jakob_Disease"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="19571912" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19571912/Creutzfeldt_Jakob_disease_in_a_patient_with_an_R208H_mutation_of_the_prion_protein_gene_PRNP_and_a_17_kDa_prion_protein_fragment">Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39928796" href="https://independent.academia.edu/SigrunRoeber">Sigrun Roeber</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Neuropathologica, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">A case of Creutzfeldt-Jakob disease (CJD) with a rare mutation of the prion protein (PrP) gene (PRNP) at codon 208 (R208H) is described. By comparison with two preceding reports, the case described here displayed two distinct biochemical and neuropathological features. Western blot analysis of brain homogenates showed, in addition to the commonly observed three bands of abnormal protease-resistant PrP isoform (PrP Sc ), an additional band of about 17 kDa. Neuropathological examination of the post mortem brain revealed tau pathology in the hippocampus and entorhinal cortex, as well as ballooned neurons in the cortex, hippocampus and subcortical gray matter.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment","attachmentId":40705330,"attachmentType":"pdf","work_url":"https://www.academia.edu/19571912/Creutzfeldt_Jakob_disease_in_a_patient_with_an_R208H_mutation_of_the_prion_protein_gene_PRNP_and_a_17_kDa_prion_protein_fragment","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/19571912/Creutzfeldt_Jakob_disease_in_a_patient_with_an_R208H_mutation_of_the_prion_protein_gene_PRNP_and_a_17_kDa_prion_protein_fragment"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="87466137" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/87466137/Creutzfeldt_Jakob_Disease_A_Rare_Case_Report">Creutzfeldt - Jakob Disease – A Rare Case Report</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20883077" href="https://thewbuhs.academia.edu/AjayManickam">Ajay Manickam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of medical research, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Prion diseases are neurodegenerative diseases that have incubation period. Five prion diseases are recognized they are kuru, Creutzfeldt-Jakob disease (CJD), variant CJD, Gerstmann-straussler Scheinker syndrome (GSS) and fatal familial insomnia1. Among all these disease, CJD accounts for 90% of all prion disease. One case of CJD occurs among 1,000,000 populations per year. It is such a rare presentation. Dementia and myoclonus are the most common presenting condition of CJD. This is a rare case report of a patient who had a rare clinical presentation, and finally it was diagnosed to be a case of CJD.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Creutzfeldt - Jakob Disease – A Rare Case Report","attachmentId":91666557,"attachmentType":"pdf","work_url":"https://www.academia.edu/87466137/Creutzfeldt_Jakob_Disease_A_Rare_Case_Report","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/87466137/Creutzfeldt_Jakob_Disease_A_Rare_Case_Report"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":81529830,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":81529830,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_81529830" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="93325726" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93325726/Creutzfeldt_Jakob_disease_a_survey_of_14_patients">Creutzfeldt-Jakob disease: a survey of 14 patients</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5338061" href="https://independent.academia.edu/paulomarchiori">paulo marchiori</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Arquivos de Neuro-Psiquiatria, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Creutzfeldt-Jakob disease: a survey of 14 patients","attachmentId":96094116,"attachmentType":"pdf","work_url":"https://www.academia.edu/93325726/Creutzfeldt_Jakob_disease_a_survey_of_14_patients","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/93325726/Creutzfeldt_Jakob_disease_a_survey_of_14_patients"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="105384734" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/105384734/Creutzfeldt_Jakob_disease_experience_in_patients_presenting_to_a_tertiary_care_hospital_A_case_series">Creutzfeldt-Jakob disease experience in patients presenting to a tertiary care hospital: A case series</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="146136063" href="https://independent.academia.edu/MaryamKhalil17">Maryam Khalil</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pakistan Journal of Neurological Sciences</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Creutzfeldt-Jakob disease experience in patients presenting to a tertiary care hospital: A case series","attachmentId":104852790,"attachmentType":"pdf","work_url":"https://www.academia.edu/105384734/Creutzfeldt_Jakob_disease_experience_in_patients_presenting_to_a_tertiary_care_hospital_A_case_series","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/105384734/Creutzfeldt_Jakob_disease_experience_in_patients_presenting_to_a_tertiary_care_hospital_A_case_series"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="92220915" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92220915/Prolonged_Course_of_Creutzfeldt_Jakob_disease_with_Excessive_Central_Nervous_System_Degeneration">Prolonged Course of Creutzfeldt - Jakob disease with Excessive Central Nervous System Degeneration</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="56070750" href="https://independent.academia.edu/EgonKur%C4%8Da">Egon Kurča</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prolonged Course of Creutzfeldt - Jakob disease with Excessive Central Nervous System Degeneration","attachmentId":95287525,"attachmentType":"pdf","work_url":"https://www.academia.edu/92220915/Prolonged_Course_of_Creutzfeldt_Jakob_disease_with_Excessive_Central_Nervous_System_Degeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/92220915/Prolonged_Course_of_Creutzfeldt_Jakob_disease_with_Excessive_Central_Nervous_System_Degeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="112168427" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/112168427/Creutzfeldt_Jakob_disease_associated_with_a_deletion_of_two_repeats_in_the_prion_protein_gene">Creutzfeldt-Jakob disease associated with a deletion of two repeats in the prion protein gene</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57821353" href="https://independent.academia.edu/RobertPetersen9">Robert Petersen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurology, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Creutzfeldt-Jakob disease associated with a deletion of two repeats in the prion protein 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data-author-id="108526172" href="https://independent.academia.edu/PetrosAngelopoulos">Petros Angelopoulos</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Neuroscience, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Atypical and early symptoms of sporadic Creutzfeldt – Jakob disease: case series and review of the literature","attachmentId":94154537,"attachmentType":"pdf","work_url":"https://www.academia.edu/90650645/Atypical_and_early_symptoms_of_sporadic_Creutzfeldt_Jakob_disease_case_series_and_review_of_the_literature","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/90650645/Atypical_and_early_symptoms_of_sporadic_Creutzfeldt_Jakob_disease_case_series_and_review_of_the_literature"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="61387023" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/61387023/Plaque_type_deposition_of_prion_protein_in_the_damaged_white_matter_of_sporadic_Creutzfeldt_Jakob_disease_MM1_patients">Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45690191" href="https://independent.academia.edu/KunimasaArima">Kunimasa Arima</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Acta Neuropathologica, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Plaque-type deposition of prion protein in the damaged white matter of sporadic Creutzfeldt-Jakob disease MM1 patients","attachmentId":74432903,"attachmentType":"pdf","work_url":"https://www.academia.edu/61387023/Plaque_type_deposition_of_prion_protein_in_the_damaged_white_matter_of_sporadic_Creutzfeldt_Jakob_disease_MM1_patients","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/61387023/Plaque_type_deposition_of_prion_protein_in_the_damaged_white_matter_of_sporadic_Creutzfeldt_Jakob_disease_MM1_patients"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="60744970" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/60744970/Sporadic_Creutzfeldt_Jakob_Disease_Prion_Pathology_in_Medulla_Oblongata_Possible_Routes_of_Infection_and_Host_Susceptibility">Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata—Possible Routes of Infection and Host Susceptibility</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32591111" href="https://independent.academia.edu/SergioFerrari2">Sergio Ferrari</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BioMed Research International, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata—Possible Routes of Infection and Host Susceptibility","attachmentId":74050100,"attachmentType":"pdf","work_url":"https://www.academia.edu/60744970/Sporadic_Creutzfeldt_Jakob_Disease_Prion_Pathology_in_Medulla_Oblongata_Possible_Routes_of_Infection_and_Host_Susceptibility","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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href="https://independent.academia.edu/DanFilip16">Dan Filip</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Romanian Review of Laboratory Medicine, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A case of sporadic Creutzfeldt – Jakob disease and discussion on diagnostic biomarkers","attachmentId":72905483,"attachmentType":"pdf","work_url":"https://www.academia.edu/58545513/A_case_of_sporadic_Creutzfeldt_Jakob_disease_and_discussion_on_diagnostic_biomarkers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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href="https://independent.academia.edu/AntonioIndaco">Antonio Indaco</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Pathology, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"MM2-Thalamic Creutzfeldt-Jakob Disease: Neuropathological, Biochemical and Transmission Studies Identify a Distinctive Prion Strain","attachmentId":43790575,"attachmentType":"pdf","work_url":"https://www.academia.edu/23332910/MM2_Thalamic_Creutzfeldt_Jakob_Disease_Neuropathological_Biochemical_and_Transmission_Studies_Identify_a_Distinctive_Prion_Strain","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/23332910/MM2_Thalamic_Creutzfeldt_Jakob_Disease_Neuropathological_Biochemical_and_Transmission_Studies_Identify_a_Distinctive_Prion_Strain"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="31997214" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31997214/Prion_protein_immunocytochemistry_reliable_protocols_for_the_investigation_of_Creutzfeldt_Jakob_disease">Prion protein immunocytochemistry: reliable protocols for the investigation of Creutzfeldt–Jakob disease</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="61872395" href="https://independent.academia.edu/JeanneBell2">Jeanne Bell</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neuropathology and Applied Neurobiology, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prion protein immunocytochemistry: reliable protocols for the investigation of Creutzfeldt–Jakob disease","attachmentId":52266065,"attachmentType":"pdf","work_url":"https://www.academia.edu/31997214/Prion_protein_immunocytochemistry_reliable_protocols_for_the_investigation_of_Creutzfeldt_Jakob_disease","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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