Vanishing White Matter Consortium home - Vanishing White Matter Consortium

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style="background-image: url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/foto-1-2400x1167.jpg);"> <div class="container"> <div class="row"> <div class="col-12"> <div class="cbbs__content"> <div class="h1 cbbs__title">Finding a cure for <br /> Vanishing White Matter</div> <a class="btn btn--green cbbs__btn" href="https://www.vwmconsortium.org/about-vwm/">About VWM</a> </div> </div> </div> </div> </div> <div class="cbbs__slide swiper-slide" style="background-image: url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Doctor-and-child_medium.jpg);"> <div class="container"> <div class="row"> <div class="col-12"> <div class="cbbs__content"> <div class="h1 cbbs__title">Guanabenz clinical trial<br /> enrollment started</div> <a class="btn btn--green cbbs__btn" href="https://www.vwmconsortium.org/guanabenz-vwm-clinical-trial-patient-enrollment-has-started/">Read more</a> </div> </div> </div> </div> </div> </div> <div class="swiper-pagination"></div> </div> </div> <div class="cb cb__text-logo cbtl pt-xl bg--white cbtl__logo--left"> <div class="container"> <div class="row" data-aos="fade-up" data-aos-delay="100"> <div class="col-12 col-md-6 cbtl__content ml-auto"> <h2 class="cbtl__title">Who we are</h2> <div class="cbtl__text mb-s"><p>The Vanishing White Matter Consortium (VWM) consists of 9 (pediatric) neurologists from 8 academic medical centers worldwide, all involved in leukodystrophy patient care and research. Together with our partners, we work towards a cure for VWM.</p> </div> <a class="btn btn--green cbtl__btn" href="https://www.vwmconsortium.org/about-us/">More about us</a> </div> </div> </div> </div> <div class="cb cb__text-image cbti p-xl bg--white"> <div class="container"> <div class="row" data-aos="fade-up" data-aos-delay="100"> <div class="col-12 col-md-6 cbti__image order--right"> <img decoding="async" src="https://www.vwmconsortium.org/wp-content/uploads/2021/06/Teamwork_medium.jpg" alt=""> </div> <div class="col-12 col-md-6 cbti__content"> <h2 class="cbti__title">Mission statement</h2> <div class="cbti__text"><p>Our mission is to enable and accelerate therapeutics for Vanishing White Matter, aiming at accessibility and affordability for all patients. To this purpose, we established an international collaboration, which engages partners to provide unbiased analyses of different therapeutics, using smart trial design to address recruitment challenges of this rare disease. We work together with a number of partner organizations, including academic institutes, biotech and pharma companies, and patient and family organizations.</p> </div> </div> </div> </div> </div> <div class="cb cb__news cbn p-l bg--light-purple"> <div class="container"> <div class="row"> <div class="col-12"> <div class="cbn__titles"> <div class="h2 cbn__title">Our latest News Articles</div> <a class="btn--round" href="https://www.vwmconsortium.org/news/"> <div class="btn--round-text">All News</div> <div class="btn--round-arrow"></div> </a> </div> </div> </div> <div class="row"> <div class="col-12 col-sm-6 col-md-4"> <a href="https://www.vwmconsortium.org/the-core-protocol-for-phase-2-3-clinical-trials-in-vwm-is-now-published/" class="card card-news"> <div class="card-news__image" style="background-image: url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Teamwork_medium-640x480.jpg);"> </div> <div class="card-news__content bg--white"> <div class="card-news__btn btn--round"> <div class="btn--round-arrow"></div> </div> <div class="card-news__date">21 augustus 2023</div> <div class="h4 card-news__title">The core protocol for phase 2/3 clinical trial(s) in VWM is now published</div> <div class="card-news__text">The core protocol for phase 2/3 clinical trial(s) in VWM, aimed to serve as a template for industry-sponsored clinical trials in VWM, is now published. </div> </div> </a> </div> <div class="col-12 col-sm-6 col-md-4"> <a href="https://www.vwmconsortium.org/calico-life-sciences-announces-first-participant-dosed-in-phase-1b-clinical-study-evaluating-abbv-cls-7262-for-the-treatment-of-vanishing-white-matter-disease/" class="card card-news"> <div class="card-news__image" style="background-image: url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Teamwork_medium-640x480.jpg);"> </div> <div class="card-news__content bg--white"> <div class="card-news__btn btn--round"> <div class="btn--round-arrow"></div> </div> <div class="card-news__date">26 april 2023</div> <div class="h4 card-news__title">Calico Life Sciences Announces First Participant Dosed in Phase 1b Clinical Study Evaluating ABBV-CLS-7262 for the Treatment of Vanishing White Matter Disease</div> <div class="card-news__text">Calico Life Sciences Announces First Participant Dosed in Phase 1b Clinical Study Evaluating ABBV-CLS-7262 for the Treatment of Vanishing White Matter Disease</div> </div> </a> </div> <div class="col-12 col-sm-6 col-md-4"> <a href="https://www.vwmconsortium.org/calico-starts-phase-1b-study-evaluating-safety-tolerability-and-pharmacokinetics-of-eif2b-activator/" class="card card-news"> <div class="card-news__image" style="background-image: url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/iStock-1185390850_medium-640x480.jpg);"> </div> <div class="card-news__content bg--white"> <div class="card-news__btn btn--round"> <div class="btn--round-arrow"></div> </div> <div class="card-news__date">26 maart 2023</div> <div class="h4 card-news__title">Calico starts phase 1b study evaluating safety, tolerability and pharmacokinetics of eIF2B activator</div> <div class="card-news__text">Calico starts phase 1b study evaluating safety, tolerability and pharmacokinetics of eIF2B activator. </div> </div> </a> </div> </div> </div> </div> <div class="cb cb__current-trial cbct p-xl" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Doctor-and-child_medium.jpg);"> <div class="cbct__content"> <div class="container"> <div class="row justify-content-center" data-aos="fade-up" data-aos-delay="100"> <div class="col-12 col-sm-9 cbct__content-inner"> <div class="cbct__content-upper"> <div class="h5 cbct__content-upper-title">Current Trial</div>  </div> <h2 class="cbct__title">Guanabenz trial for Vanishing White Matter</h2> <div class="cbct__text"><p>The Amsterdam Leukodystrophy Center at the Amsterdam University Medical Centers (Amsterdam UMC) is conducting a clinical trial in children with Vanishing White Matter (VWM). In this trial, we want to evaluate whether a drug called Guanabenz is effective in slowing progression, stabilizing, or even improving the brain white matter abnormalities in VWM.</p> </div> <a class="btn btn--green cbct__btn" href="https://www.vwmconsortium.org/guanabenz-trial-for-vwm/">Read more</a> </div> </div> </div> </div> </div> <div class="cb cb__logos cbl p-l bg--white"> <div class="container"> <div class="row"> <div class="col-12"> <div class="cbl__titles"> <div class="h2 cbl__title">Consortium Members</div> <a class="btn--round" href="https://www.vwmconsortium.org/about-us/"> <div class="btn--round-text">More info</div> <div class="btn--round-arrow"></div> </a> </div> </div> </div> <div class="row"> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Amsterdam-UMC.jpg);"></div> </div> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/University-of-Utah.jpg);"></div> </div> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Childrens-hospital-of-Philadelphia.jpg);"></div> </div> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/KKI-black-kopie-400x171.jpg);"></div> </div> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/McGill-University.jpg);"></div> </div> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Bambino-Gesu.jpg);"></div> </div> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2021/06/Tubingen.jpg);"></div> </div> <div class="col-6 col-sm-4 col-md-3 cbl__col p-s" data-aos="fade-up" data-aos-delay="100"> <div class="cbl__logo" style="background-image:url(https://www.vwmconsortium.org/wp-content/uploads/2022/04/ucla_wc-400x185.jpg);"></div> </div> </div> </div> </div> <div class="cb cb__text-logo cbtl pb-xl bg--white cbtl__logo--right"> <div class="container"> <div class="row" data-aos="fade-up" data-aos-delay="100"> <div class="col-12 col-md-6 cbtl__content "> <h2 class="cbtl__title">Partners</h2> <div class="cbtl__text mb-s"><p>To achieve our mission and work towards a treatment for Vanishing White Matter, our consortium works together with a number of partner organizations, including academic institutes, biotech, and pharma companies, and patient and family organizations.</p> </div> <a class="btn btn--green cbtl__btn" href="https://www.vwmconsortium.org/partners/">All our partners</a> </div> </div> </div> </div> </div> </main> <footer class="footer p-l"> <div class="container"> <div class="row"> <div class="col-12 col-sm-6 footer__logo__text"> <div class="footer__logo__img"></div> <p>The Vanishing White Matter consortium consists of 9 (pediatric) neurologists from 8 academic medical centers worldwide, all involved in leukodystrophy patient care and research. The consortium started in 2019 to work on the overarching mission: enabling and accelerating therapeutics for Vanishing White Matter, accessible and affordable for all patients. To help us achieve our mission we interact with various partners, including patient / family / caregiver foundations, (medical) specialists, academic institutes, and biotech and pharma companies.</p> </div> <div class="col-12 col-sm-6 footer__registry"> <div class="footer__registry__content"> <h3 class="footer__registry__titel">VWM patient registry</h3> <div class="footer__registry__text"> <p>The Amsterdam Leukodystrophy Center has developed an online global registry for patients with Vanishing White Matter (VWM). The purpose of the registry is to gain as much insight as possible into the course of the disease, both in terms of clinical features and MRI. This database will play an important role in developing treatment strategies and making decisions about therapeutic trials. Information is needed about as many patients as possible.</p> </div> <a href="https://www.vwmconsortium.org/register-as-vanishing-white-matter-patient/" class="footer__registry__button btn btn--green">Register</a> </div> </div> </div> <div class="row footer__bar justify-content-between"> <div class="col-12 footer__bar-col"> <div class="footer__copyright"> <div class="footer__bar-links">© 2025 <p>Amsterdam UMC • <a href="https://www.amsterdamumc.org/research/disclaimer.htm" target="_blank" rel="noopener">Disclaimer</a> • <a href="https://www.amsterdamumc.org/research/general-privacy-statement.htm" target="_blank" rel="noopener">Privacy Policy</a></p> </div> </div> <a href="https://www.stoerebinken.nl/" class="footer__made-by" target="_blank">Website: Stoere Binken</a> </div> </div> </div> </footer> <script type="text/javascript" src="https://unpkg.com/aos@next/dist/aos.js?ver=6.7.2" id="aos-js"></script> <script type="text/javascript" src="https://www.vwmconsortium.org/wp-includes/js/imagesloaded.min.js?ver=5.0.0" id="imagesloaded-js"></script> <script type="text/javascript" src="https://www.vwmconsortium.org/wp-includes/js/masonry.min.js?ver=4.2.2" id="masonry-js"></script> </body> </html>

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