CINXE.COM

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href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/zebrafish" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--5">Zebrafish (61)<span class="element-invisible"> Apply Zebrafish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/tbd" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--6">TBD (58)<span class="element-invisible"> Apply TBD filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/rats" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--7">Rats (35)<span class="element-invisible"> Apply Rats filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/monkey" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--8">Monkey (15)<span class="element-invisible"> Apply Monkey filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/macaque" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--9">Macaque (13)<span class="element-invisible"> Apply Macaque filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/other" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--10">Other (8)<span class="element-invisible"> Apply Other filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/chicken" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--11">Chicken (8)<span class="element-invisible"> Apply Chicken filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/drosophila" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--12">Drosophila (7)<span class="element-invisible"> Apply Drosophila filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/hamster" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--13">Hamster (6)<span class="element-invisible"> Apply Hamster filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/pig" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--14">Pig (3)<span class="element-invisible"> Apply Pig filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/rainbow-trout" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--15">rainbow trout (3)<span class="element-invisible"> Apply rainbow trout filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/monkeys" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--16">Monkeys (3)<span class="element-invisible"> Apply Monkeys filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/dog" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--17">Dog (2)<span class="element-invisible"> Apply Dog filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/zebra-finch" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--18">Zebra Finch (2)<span class="element-invisible"> Apply Zebra Finch filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/mouse-humanized" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--19">Mouse (Humanized) (2)<span class="element-invisible"> Apply Mouse (Humanized) filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/macaques" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--20">Macaques (2)<span class="element-invisible"> Apply Macaques filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/mosquito" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--21">Mosquito (2)<span class="element-invisible"> Apply Mosquito filter </span></a></li><li class="leaf"><span class='inactive-link'><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/mouse-embryo" rel="nofollow" class="facetapi-checkbox facetapi-active" id="facetapi-link--22">(-) <span class="element-invisible"> Remove Fly filter </span></a></span><span class='inactive-label'>Fly (2)</span></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/trichoplax-adhaerens" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--23">Trichoplax adhaerens (2)<span class="element-invisible"> Apply Trichoplax adhaerens filter </span></a></li><li class="leaf"><span class='inactive-link'><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly" rel="nofollow" class="facetapi-checkbox facetapi-active" id="facetapi-link--24">(-) <span class="element-invisible"> Remove Mouse embryo filter </span></a></span><span class='inactive-label'>Mouse embryo (2)</span></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/bovine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--25">Bovine (1)<span class="element-invisible"> Apply Bovine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/hepatitis-b-virus" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--26">Hepatitis B virus (1)<span class="element-invisible"> Apply Hepatitis B virus filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/fruit-fly" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--27">Fruit Fly (1)<span class="element-invisible"> Apply Fruit Fly filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/sheep" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--28">Sheep (1)<span class="element-invisible"> Apply Sheep filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/japanese-medaka" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--29">Japanese medaka (1)<span class="element-invisible"> Apply Japanese medaka filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/guinea-pig" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--30">Guinea pig (1)<span class="element-invisible"> Apply Guinea pig filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/canine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--31">Canine (1)<span class="element-invisible"> Apply Canine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/salmon" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--32">Salmon (1)<span class="element-invisible"> Apply Salmon filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/honey-bee" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--33">honey bee (1)<span class="element-invisible"> Apply honey bee filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/chimpanzee" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--34">chimpanzee (1)<span class="element-invisible"> Apply chimpanzee filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/marmoset" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--35">Marmoset (1)<span class="element-invisible"> Apply Marmoset filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/fish" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--36">Fish (1)<span class="element-invisible"> Apply Fish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/mouse-human-probes" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--37">Mouse (Human Probes) (1)<span class="element-invisible"> Apply Mouse (Human Probes) filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/bat" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--38">Bat (1)<span class="element-invisible"> Apply Bat filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/frog" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--39">Frog (1)<span class="element-invisible"> Apply Frog filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/ferret" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--40">Ferret (1)<span class="element-invisible"> Apply Ferret filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/locust" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--41">Locust (1)<span class="element-invisible"> Apply Locust filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/salamander" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--42">Salamander (1)<span class="element-invisible"> Apply Salamander filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/mouse-0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--43">Mouse ? (1)<span class="element-invisible"> Apply Mouse ? filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/medaka%C2%A0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--44">Medaka (1)<span class="element-invisible"> Apply Medaka filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/avian" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--45">Avian (1)<span class="element-invisible"> Apply Avian filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/rhesus-macaques" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--46">rhesus macaques (1)<span class="element-invisible"> Apply rhesus macaques filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/budgerigars" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--47">Budgerigars (1)<span class="element-invisible"> Apply Budgerigars filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/zebrafish%C2%A0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--48">Zebrafish (1)<span class="element-invisible"> Apply Zebrafish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/monocyte-derived-macrophages" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--49">Monocyte-derived macrophages (1)<span class="element-invisible"> Apply Monocyte-derived macrophages filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/human-cell-cultures" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--50">Human Cell Cultures (1)<span class="element-invisible"> Apply Human Cell Cultures filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/speciescommon/murine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--51">Murine (1)<span class="element-invisible"> Apply Murine filter </span></a></li></ul></div></div></div><div id="block-facetapi-me8miflrpzemzgefduwk3xxabiv13rxf" class="block block-facetapi clearfix"><h2 class="title">Product</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-im-field-product" id="facetapi-facet-apachesolrpublication-solr-server-block-im-field-product"><li class="leaf first"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/product/rnascope-multiplex-fluorescent-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--57">RNAscope Multiplex Fluorescent Assay (3)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent Assay filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-embryo/product/rnascope-multiplex-fluorescent-v2" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--58">RNAscope Multiplex Fluorescent v2 (1)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent v2 filter </span></a></li></ul></div></div></div></div></div></div></div><div class="col-sm-9 result"><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div class="search-results apachesolr_search-results"><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.nature.com/articles/s41467-022-29071-4"> Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria </a></div></div><div class="col-sm-2"><p>Nature communications</p></div><div class="col-sm-2"><p>2022 Mar 24</p></div><div class="clear"></div><div class="col-sm-8"><p> Yang, H;Sibilla, C;Liu, R;Yun, J;Hay, BA;Blackstone, C;Chan, DC;Harvey, RJ;Guo, M; <br/> PMID: <a href="https://www.nature.com/articles/s41467-022-29071-4" target="_blank">35332133</a> | DOI: 10.1038/s41467-022-29071-4</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Mitochondrial fission is critically important for controlling mitochondrial morphology, function, quality and transport. Drp1 is the master regulator driving mitochondrial fission, but exactly how Drp1 is regulated remains unclear. Here, we identified Drosophila Clueless and its mammalian orthologue CLUH as key regulators of Drp1. As with loss of drp1, depletion of clueless or CLUH results in mitochondrial elongation, while as with drp1 overexpression, clueless or CLUH overexpression leads to mitochondrial fragmentation. Importantly, drp1 overexpression rescues adult lethality, tissue disintegration and mitochondrial defects of clueless null mutants in Drosophila. Mechanistically, Clueless and CLUH promote recruitment of Drp1 to mitochondria from the cytosol. This involves CLUH binding to mRNAs encoding Drp1 receptors MiD49 and Mff, and regulation of their translation. Our findings identify a crucial role of Clueless and CLUH in controlling mitochondrial fission through regulation of Drp1.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling</div></div><div class="col-sm-2"><p>Nature communications</p></div><div class="col-sm-2"><p>2021 Apr 23</p></div><div class="clear"></div><div class="col-sm-8"><p> Yin, J;Spillman, E;Cheng, ES;Short, J;Chen, Y;Lei, J;Gibbs, M;Rosenthal, JS;Sheng, C;Chen, YX;Veerasammy, K;Choetso, T;Abzalimov, R;Wang, B;Han, C;He, Y;Yuan, Q; <br/> PMID: 33893307 | DOI: 10.1038/s41467-021-22751-7</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Lipid shuttling between neurons and glia contributes to the development, function, and stress responses of the nervous system. To understand how a neuron acquires its lipid supply from specific lipoproteins and their receptors, we perform combined genetic, transcriptome, and biochemical analyses in the developing Drosophila larval brain. Here we report, the astrocyte-derived secreted lipocalin Glial Lazarillo (GLaz), a homolog of human Apolipoprotein D (APOD), and its neuronal receptor, the brain-specific short isoforms of Drosophila lipophorin receptor 1 (LpR1-short), cooperatively mediate neuron-glia lipid shuttling and support dendrite morphogenesis. The isoform specificity of LpR1 defines its distribution, binding partners, and ability to support proper dendrite growth and synaptic connectivity. By demonstrating physical and functional interactions between GLaz/APOD and LpR1, we elucidate molecular pathways mediating lipid trafficking in the fly brain, and provide in vivo evidence indicating isoform-specific expression of lipoprotein receptors as a key mechanism for regulating cell-type specific lipid recruitment.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification</div></div><div class="col-sm-2"><p>The Journal of biological chemistry</p></div><div class="col-sm-2"><p>2021 Jul 28</p></div><div class="clear"></div><div class="col-sm-8"><p> Almubarak, A;Lavy, R;Srnic, N;Hu, Y;Maripuri, DP;Kume, T;Berry, FB; <br/> PMID: 34331943 | DOI: 10.1016/j.jbc.2021.101020</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Endochondral ossification initiates the growth of the majority of the mammalian skeleton and is tightly controlled through gene regulatory networks. The forkhead box transcription factors Foxc1 and Foxc2 have been demonstrated to regulate aspects of osteoblast function in the formation of the skeleton but their roles in chondrocytes to control endochondral ossification are less clear. Here we demonstrate that Foxc1 expression is directly regulated by the activity of SOX9, one of the earliest transcription factors to specify the chondrocyte lineage. Moreover, we demonstrate that elevated expression of Foxc1 promotes chondrocyte differentiation in mouse embryonic stem cells and loss of Foxc1 function inhibits chondrogenesis in vitro. Using chondrocyte-targeted deletion of Foxc1 and Foxc2 in mice, we reveal a role for these factors in chondrocyte differentiation in vivo. Loss of both Foxc1 and Foxc2 caused a general skeletal dysplasia predominantly affecting the vertebral column. The long bones of the limbs were smaller, mineralization was reduced, and organization of the growth plate was disrupted; in particular, the stacked columnar organization of the proliferative chondrocyte layer was reduced in size and cell proliferation in growth plate chondrocytes was reduced. Differential gene expression analysis indicated disrupted expression patterns of chondrogenesis and ossification genes throughout the entire process of endochondral ossification in chondrocyte-specific Foxc1/Foxc2 knockout embryos. Our results suggest that Foxc1 and Foxc2 are required for normal chondrocyte differentiation and function, as loss of both genes results in disorganization of the growth plate, reduced chondrocyte proliferation, and delays in chondrocyte hypertrophy that prevents ossification of the skeleton.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice</div></div><div class="col-sm-2"><p>Behavioural brain research</p></div><div class="col-sm-2"><p>2021 May 09</p></div><div class="clear"></div><div class="col-sm-8"><p> Vuong, HE;Coley, EJL;Kazantsev, M;Cooke, ME;Rendon, TK;Paramo, J;Hsiao, EY; <br/> PMID: 33979656 | DOI: 10.1016/j.bbr.2021.113353</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Selective serotonin reuptake inhibitors (SSRIs) are the most widely used treatment by women experiencing depression during pregnancy. However, the effects of maternal SSRI use on early offspring development remain poorly understood. Recent studies suggest that SSRIs can modify the gut microbiota and interact directly with particular gut bacteria, raising the question of whether the gut microbiome impacts host responses to SSRIs. In this study, we investigate effects of prenatal SSRI exposure on fetal neurodevelopment and further evaluate potential modulatory influences of the maternal gut microbiome. We demonstrate that maternal treatment with the SSRI fluoxetine induces widespread alterations in the fetal brain transcriptome during midgestation, including increases in the expression of genes relevant to synaptic organization and neuronal signaling and decreases in the expression of genes related to DNA replication and mitosis. Notably, maternal fluoxetine treatment from E7.5 to E14.5 has no overt effects on the composition of the maternal gut microbiota. However, maternal pretreatment with antibiotics to deplete the gut microbiome substantially modifies transcriptional responses of the fetal brain to maternal fluoxetine treatment. In particular, maternal fluoxetine treatment elevates localized expression of the opioid binding protein/cell adhesion molecule like gene Opcml in the fetal thalamus and lateral ganglionic eminence, which is prevented by maternal antibiotic treatment. 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text-align: center; text-decoration: none; display: inline-block; cursor: pointer; } .embeddedServiceInvitationFooter > #acceptInvite { background-color: #005290; color: #FFFFFF; } .embeddedServiceInvitationFooter > #rejectInvite { background-color: #FFFFFF; color: #005290; } </style>   <input type="hidden" name="liveagent.prechat.findorcreate.map.doFind:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.isExactMatch:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.doCreate:Contact" value="LastName,true;FirstName,true;Email,true" /> <script type='text/javascript'> (function() { document.getElementById('closeInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; document.getElementById('rejectInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; // use this API call to reject invitations document.getElementById('acceptInvite').onclick = function() { embedded_svc.liveAgentAPI.startChat({ directToButtonRouting: { buttonId: "5733t000000cVk9" }, extraPrechatInfo: [], extraPrechatFormDetails: [] }); }; // use this API call to start chat from invitations document.addEventListener('keyup', function(event) { if (event.keyCode == 27) { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }}) })(); </script>  <script type='text/javascript' src='https://service.force.com/embeddedservice/5.0/esw.min.js'></script> <script type='text/javascript'> var initESW = function(gslbBaseURL) { embedded_svc.settings.displayHelpButton = true; //Or false embedded_svc.settings.language = ''; //For example, enter 'en' or 'en-US' embedded_svc.settings.defaultMinimizedText = 'Chat now'; //(Defaults to Chat with an Expert) embedded_svc.settings.disabledMinimizedText = 'Leave a message'; //(Defaults to Agent Offline) embedded_svc.settings.autoOpenPostChat = true; //embedded_svc.settings.loadingText = ''; //(Defaults to Loading) //embedded_svc.settings.storageDomain = 'yourdomain.com'; //(Sets the domain for your deployment so that visitors can navigate subdomains during a chat session) // Settings for Chat embedded_svc.settings.directToButtonRouting = function (prechatFormData) { if (prechatFormData[4].value === "Technical Service") return "5733t000000XZAM"; if (prechatFormData[4].value === "Customer Care") return "5733t000000XZAH"; }; embedded_svc.settings.prepopulatedPrechatFields = { OmniURL__c: window.location.href, ChooseaDepartment__c: 'Technical Service' }; //Sets the auto-population of pre-chat form fields embedded_svc.settings.extraPrechatFormDetails = [{ "label":"Source Domain", "value":window.location.href, "transcriptFields":[ "Source_Domain__c" ], "displayToAgent":true }]; //embedded_svc.settings.fallbackRouting = []; //An array of button IDs, user IDs, or userId_buttonId embedded_svc.settings.offlineSupportMinimizedText = 'Leave a message'; //(Defaults to Contact Us) embedded_svc.settings.enabledFeatures = ['LiveAgent']; embedded_svc.settings.entryFeature = 'LiveAgent'; embedded_svc.init( 'https://biotechne.my.salesforce.com', 'https://biotechne.my.salesforce-sites.com/LiveAgent', gslbBaseURL, '00D500000006gkl', 'ACD_Chat_Automated', { baseLiveAgentContentURL: 'https://c.la1-c1-ia5.salesforceliveagent.com/content', deploymentId: '572380000004CqL', buttonId: '5733t000000cVk9', baseLiveAgentURL: 'https://d.la1-c1-ia5.salesforceliveagent.com/chat', eswLiveAgentDevName: 'EmbeddedServiceLiveAgent_Parent04I3t000000Y7zbEAC_175bb741b99', isOfflineSupportEnabled: true } ); }; if (!window.embedded_svc) { var s = document.createElement('script'); s.setAttribute('src', 'https://biotechne.my.salesforce.com/embeddedservice/5.0/esw.min.js'); s.onload = function() { initESW(null); }; document.body.appendChild(s); } else { initESW('https://service.force.com'); } </script> <script src="//rum-static.pingdom.net/pa-5c133f6e1872b50016000024.js" async></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"NRJS-dd6144c4de227d09eb4","applicationID":"1022125825","transactionName":"YFxbZkpUXBYEVkYNWVkWbEBRGlsLAVBKSkZfSQ==","queueTime":0,"applicationTime":377,"atts":"TBtYEAJOTxg=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>