CINXE.COM

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class="tab-pane fade in active profile"><h1 class="top-profile">Inflammation Research</h1><div class="sample-image"><div class="loader-image-gallery"></div><div id="film_roll" class="sample-slider"><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/7763b07edd647909a74fff881164076e.jpg?itok=dbr36TLg" width="765" height="451" alt="RNA expression of IDO1(green), IFNG(red) gene in human lung cancer tissue using RNAscope™ 2.5 HD Duplex Assay RNA in situ hybridization (ISH)"><p class="slider-below-text"> RNA expression of IDO1(green), IFNG(red) gene in human lung cancer tissue using RNAscope™ 2.5 HD Duplex Assay</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/74e2fb143b7bd2a3f89c461629d74769.jpg?itok=WEoEsm6x" width="765" height="451" alt="RNA expression of IL6 gene in Human Bladder cancer tissue using RNAscope™ 2.5 HD Assay Brown RNA in situ hybridization (ISH)"><p class="slider-below-text"> RNA expression of IL6 gene in Human Bladder cancer tissue using RNAscope™ 2.5 HD Assay Brown</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/2531f00ade04027d6c56392d96eb0093.jpg?itok=_-nLT4MZ" width="765" height="451" alt="RNA expression of IL6 gene in Human Lymphoma tissue using RNAscope™ 2.5 HD Assay Brown RNA in situ hybridization (ISH)"><p class="slider-below-text"> RNA expression of IL6 gene in Human Lymphoma tissue using RNAscope™ 2.5 HD Assay Brown</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/d3e974dbcae54e2004f3911215662049.jpg?itok=RNF9Ornu" width="765" height="451" alt="Expression of TNFA in Human Esophageal cancer tissue using RNAscope™ 2.5 HD Assay Brown RNA in situ hybridization (ISH)"><p class="slider-below-text"> Expression of TNFA in Human Esophageal cancer tissue using RNAscope™ 2.5 HD Assay Brown</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/eaf97b5b38afc03eff78f2a616779342.jpg?itok=ozkAEn2h" width="765" height="451" alt="RNA expression of IFNG(red), CD274(green) gene in human lung cancer tissue using RNAscope™ 2.5 HD Duplex Assay RNA in situ hybridization (ISH)"><p class="slider-below-text"> RNA expression of IFNG(red), CD274(green) gene in human lung cancer tissue using RNAscope™ 2.5 HD Duplex Assay</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/0a0f3a80dfa6f7d3b38feed77bde5dc1.jpg?itok=ZVcKrsZ7" width="765" height="451" alt="Expression of TNFA in human breast cancer tissue using RNAscope™ 2.5 HD Assay Brown RNA in situ hybridization (ISH)"><p class="slider-below-text"> Expression of TNFA in human breast cancer tissue using RNAscope™ 2.5 HD Assay Brown</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Human_Colorectal%20cancer_IL6_Manual%202.0%20Red_2_0.jpg?itok=MvhU8QEL" width="765" height="451" alt="Expression of IL6 RNA (red dots) in human colorectal cancer tissue, RNA in situ hybridization (ISH) using RNAscope HD assay - RED"><p class="slider-below-text"> Expression of IL6 RNA (red dots) in human colorectal cancer tissue, RNA in situ hybridization (ISH) using RNAscope HD assay - RED</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Lung%20cancer%20FFPE_0.jpg?itok=EFiiJMBS" width="765" height="451" alt="Lung cancer FFPE(RNA in situ hybridization ISH) "><p class="slider-below-text"> RNA expression of PTPRC (CD45) (green), IFNG (red) and of CD274 (PDL1) (white) in human lung cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div></div><style type="text/css"> .loader-image-gallery { position: absolute; left: 0px; top: 0px; width: 100%; height: 100%; z-index: 9999; background: url('/sites/default/files/loading_apple.gif') 50% 35% no-repeat rgb(249,249,249); background-size: 100px; opacity: .8; } .sample-image { position: relative; } </style> <script type="text/javascript"> jQuery(document).ready(function($) { // $('#film_roll').hide(); function preloader(){ $('.loader-image-gallery').hide(); $('#film_roll').show(); } window.onload = preloader; }); </script> </div><div class="profile-content application_node_47485"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><div class="show-hide"><div class="r-show"><p>Inflammation is associated with a wide range of diseases, including asthma, arthritis, cancer, obesity, heart disease, colitis and neurological disorders, among many others. Detection of secreted factors and their receptors and cellular origin, as well as other biomarkers, are critical for understanding, diagnosing and treating many inflammatory diseases.</p><p>The RNAscope™ <em>in situ</em> hybridization assay offers a very reliable and robust method for the detection and validation of inflammatory biomarkers within the tissue environment and can be performed on routinely available FFPE samples. Several studies have been published demonstrating the application of the RNAscope ISH assay in inflammatory-related research:</p><ul><li>Identification of cytokines and their cellular origin</li><li>Detection of long non-coding RNA (lncRNA) in inflammatory diseases</li><li>Role of inflammatory pathways during carcinogenesis</li><li>Therapeutic potential of secreted proteins in inflammatory diseases</li><li>Dual ISH-IHC to detect cytokines</li></ul></div><div class="r-hide"><p><strong>Identification of cytokines and their cellular origins</strong><br />IL6 is known to contribute to the development and/or progression of prostate cancer, yet the source of IL6 production has not been well defined. Yu <em>et al</em>. used RNAscope ISH to show that <em>IL6 </em>expression was nearly exclusively restricted to the prostate stromal compartment. <em>IL6 </em>was detected in the endothelium, stroma, and areas of inflammation, but it was not detected in primary and metastatic prostate adenocarcinoma cells. These findings suggest that paracrine, and not autocrine, IL6 production is associated with prostate cancer disease progression. <a href="http://acdbio.com/search/site/%252ASilver%20JS%2C%20Kearley%20J%252A/cms/science"><em>A paracrine role for IL6 in prostate cancer patients: Lack of production by primary or metastatic tumor cells</em></a></p><p><strong>Detection of long non-coding RNA (lncRNA) in inflammatory diseases</strong><br />Long non-coding RNAs (lncRNAs) are emerging as unique inflammatory biomarkers that may be associated with a physiological or diseased state. Castellanos-Rubio <em>et al.</em> have identified a lncRNA, lnc13, that is associated with susceptibility to celiac disease. Because lncRNAs do not translate into protein, RNAscope ISH was used to show localization of lnc13 to the intestinal <em>lamina propria</em> and that lnc13 expression is decreased in patients with celiac disease. <a href="https://acdbio.com/search/site/%252ACastellanos-Rubio%252A/cms/science"><em>A long noncoding RNA associated with susceptibility to celiac disease.</em></a></p><p><strong>Role of inflammatory pathways during carcinogenesis</strong><br />Inflammation plays a critical role in the pathogenesis of ovarian cancer, and elevated systemic levels of inflammatory biomarkers are predictive of ovarian cancer progression. Gupta <em>et al.</em> sought out to see if differences in the cytokine TNFα by histological subtype and inflammatory exposures could provide further insight into ovarian cancer risk and pathogenesis. Due to the lack validated anti-cytokine antibodies for FFPE tissues, the authors used RNAscope ISH to show that <em>TNF</em><em>α</em> varies by ovarian cancer histological subtype and supports a role for inflammation in ovarian carcinogenesis. <a href="https://acdbio.com/search/site/%252AGupta%20M%2C%20Babic%20A%252A/cms/science"><em>TNF-α expression, risk factors, and inflammatory exposures in ovarian cancer: evidence for an inflammatory pathway of ovarian carcinogenesis?</em></a></p><p><strong>Therapeutic potential of secreted proteins in inflammatory diseases</strong><br />FNDC4 is a secreted protein that is robustly upregulated during inflammation, and could be a potential therapeutic for the treatment of inflammatory bowel disease and other inflammatory disease. To identify the cells producing <em>Fndc4</em> in a mouse model of induced colitis, Bosma <em>et al</em>. used RNAscope ISH to show that colonic epithelial cells and a subset of immune cells in lymphoid aggregates produce <em>Fndc4</em>. <a href="https://acdbio.com/search/site/%252Abosma%252A/cms/science"><em>FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.</em></a></p><p><strong>Dual ISH-IHC to detect cytokines during inflammatory responses</strong><br />Innate lymphoid cells (ILCs) are tissue-resident innate immune lymphocytes with diverse roles in mucosal inflammation. Silver <em>et al.</em> found that group 2 ILC (ILC2) cells exhibit functional plasticity depending on the inflammatory milieu. Dual RNAscope ISH-IHC detected inflammatory signals that co-localized with ILCs in lung tissue from mice infected with influenza A virus: ISH detected the secreted cytokines <em>IL18</em> and <em>IL1</em>2 while IHC detected GFP, which represented ST2 (IL33 receptor) expression. These data revealed that myeloid-derived cells expressing <em>IL12</em> and <em>IL18</em> mRNA were frequently identified in close proximity to ILCs expressing the IL33 receptor within inflamed airways. <a href="https://acdbio.com/search/site/%252ASilver%20JS%2C%20Kearley%20J%252A/cms/science"><em>Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs</em></a></p></div></div></div></div></div><div class="view view-application view-id-application view-display-id-block_8 view-dom-id-51290d4826b85776f4fa888e8855b2f5"><div class="view-content"><div class="row immuno-watch"><h3 style="font-size: 24px;font-weight: 500;margin-left: 15px;margin-bottom: 0">Recorded Webinar</h3><div class="col-md-6"><p>Watch recorded webinar to learn more about the ACD study: Visualization of LGR5+ Stem Cells and the immune response in the inflamed mouse colon with RNAscope Assay presented by one of our Senior Scientists at ACD.</p> <a class="immu-watch-link" href="https://youtu.be/cbfL6RfK5ow"> Watch Webinar </a></div><div class="col-md-6"> <img src="https://acdbio.com/sites/default/files/stemcell-webinar_0.png" /></div></div></div></div><div class="view view-application view-id-application view-display-id-block_9 view-dom-id-0440be84647464ab6bd1bb404af9db56"><div class="view-content"><style type="text/css"> .view-id-application.view-display-id-block_9 .row.immuno-watch { margin-top: 15px; margin-bottom: 15px; } </style></div></div></div><div class="sample-image"><div class="profile-bottom"><h2>Application review</h2><p>Specific Detection of Inflammation Markers within Tissue Context Using RNAscope Technology</p><div class="row review"><div class="col-md-6"> <img src="/sites/default/files/inflammation_appreview1.jpg"></div><div class="col-md-6"><h2>Specific Detection of Inflammation Markers with Tissue Context Using RNAscope Technology</h2><p>To download the application review please fill out the form below:</p><div class="marketo-container download-pdf-app"><form id="mktoForm_9725" rel="9725"> </form> <a href="" class="down-pdf-btn marketo-popup">Download Pdf</a></div></div><div class="clear"></div></div></div></div><div id="animal-models"><div class="immuno-content animalmodels-bottom-wrap"><div class="animalmodels-bottom"><div class="container"><div class="row viruses"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"><div class="sec-title" style="line-height: 20.8px; border-bottom: none;">Inflammation Gene List</div><p style="line-height: 20.8px;">(Click on the name to access corresponding RNAscope Catalog Probes)</p><p style="line-height: 20.8px;"> </p><div class="row"><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/ADAM17">ADAM17</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AGER">AGER</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AGT">AGT</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AHR">AHR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AHSG">AHSG</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AICDA">AICDA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AKT1">AKT1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ANGPT1">ANGPT1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ANGPT2">ANGPT2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ANXA1">ANXA1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/APOA1">APOA1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/APOE">APOE</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/APP">APP</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/BCL2">BCL2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/BDKRB1">BDKRB1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/BDKRB2">BDKRB2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/BDNF">BDNF</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/C3">C3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/C5AR1">C5AR1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CALCA">CALCA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CAMP">CAMP</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CASP1">CASP1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CAV1">CAV1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCL11">CCL11</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCL2">CCL2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCL20">CCL20</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCL5">CCL5</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCR1">CCR1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCR2">CCR2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCR3">CCR3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CCR5">CCR5</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CD14">CD14</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CD163">CD163</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CD274">CD274</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CD40">CD40</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CD40LG">CD40LG</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CD44">CD44</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDKN1A">CDKN1A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CFH">CFH</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CFTR">CFTR</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/CHI3L1">CHI3L1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CHN1">CHN1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CLEC4C">CLEC4C</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CNR2">CNR2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CRH">CRH</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CRP">CRP</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CSF2">CSF2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CTLA4">CTLA4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CTNNB1">CTNNB1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CX3CL1">CX3CL1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CX3CR1">CX3CR1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL1">CXCL1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL10">CXCL10</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL12">CXCL12</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL13">CXCL13</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL2">CXCL2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL5">CXCL5</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL8">CXCL8</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCL9">CXCL9</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCR2">CXCR2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCR3">CXCR3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CXCR4">CXCR4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/DEFB4A">DEFB4A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/DPP4">DPP4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/EDN1">EDN1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/EGFR">EGFR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/EGR1">EGR1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ENTPD1">ENTPD1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/EPHB3">EPHB3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/F2R">F2R</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/F2RL1">F2RL1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/F3">F3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FABP4">FABP4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FAS">FAS</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FASLG">FASLG</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FCGR1A">FCGR1A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FCGR2A">FCGR2A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FCGR2B">FCGR2B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FCGR3A-O1">FCGR3A-O1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FLT1">FLT1</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/FN1">FN1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FOXP3">FOXP3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FPR2">FPR2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/GAS6">GAS6</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/GATA6">GATA6</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/GDF15">GDF15</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/GHRL">GHRL</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/GRN">GRN</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/GSK3B">GSK3B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/HAMP">HAMP</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/HGF">HGF</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/HIF1A">HIF1A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/HLA-G">HLA-G</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/HMGB1">HMGB1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/HMOX1">HMOX1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/HSD11B1">HSD11B1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ICAM1">ICAM1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IDO1">IDO1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IFNG">IFNG</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IGF1">IGF1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL10">IL10</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL11">IL11</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL12A">IL12A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL12B">IL12B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL13">IL13</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL15">IL15</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL16">IL16</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL17A">IL17A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL17F">IL17F</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL18">IL18</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL1A">IL1A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL1B">IL1B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL1R1">IL1R1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL1RL1">IL1RL1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL1RN">IL1RN</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL21">IL21</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL22">IL22</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL23A">IL23A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL27">IL27</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL2RA">IL2RA</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/IL33">IL33</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL4">IL4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL4R">IL4R</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL5">IL5</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL6">IL6</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL6R">IL6R</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IL6ST">IL6ST</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IRAK1">IRAK1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ITGAM">ITGAM</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ITGB2">ITGB2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/JUN">JUN</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/LCN2">LCN2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/LEP">LEP</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/LGALS3">LGALS3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/LTA">LTA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/LTB4R">LTB4R</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/LTF">LTF</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MAPK1">MAPK1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MAPK3">MAPK3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MAPK8">MAPK8</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MGST3">MGST3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MIF">MIF</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MMP1">MMP1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MMP2">MMP2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MMP3">MMP3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MMP9">MMP9</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MPO">MPO</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MTHFR">MTHFR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MUC1">MUC1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MUC5AC">MUC5AC</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MYD88">MYD88</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NAMPT">NAMPT</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NFE2L2">NFE2L2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NFKB1">NFKB1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NGF">NGF</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NLRP3">NLRP3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NOD1">NOD1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NOD2">NOD2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NOS2">NOS2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NOS3">NOS3</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/NOX1">NOX1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NPPB">NPPB</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NR1H3">NR1H3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NR3C1">NR3C1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/OSM">OSM</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/P2RX7">P2RX7</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PARP1">PARP1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PDCD1">PDCD1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PECAM1">PECAM1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PLA2G7">PLA2G7</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PLAU">PLAU</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PLAUR">PLAUR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PPARA">PPARA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PPARG">PPARG</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PROC">PROC</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PROCR">PROCR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PRTN3">PRTN3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PTEN">PTEN</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PTGDR2">PTGDR2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PTGER4">PTGER4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PTGS1">PTGS1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PTGS2">PTGS2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PYCARD">PYCARD</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/RARRES2">RARRES2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/RBP4">RBP4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/RELA">RELA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/S100A8">S100A8</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/S100A9">S100A9</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/S100B">S100B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SCGB1A1">SCGB1A1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SDC1">SDC1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SELE">SELE</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SELP">SELP</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SERPINA1">SERPINA1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SERPINE1">SERPINE1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SIRT1">SIRT1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SNCA">SNCA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SOCS3">SOCS3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SOD1">SOD1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SPAM1">SPAM1</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/SPHK1">SPHK1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SPP1">SPP1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/STAT1">STAT1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/STAT3">STAT3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SYK">SYK</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TAC1">TAC1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TACR1">TACR1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TGFB1">TGFB1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TGM2">TGM2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/THBD">THBD</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/THBS1">THBS1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TLR2">TLR2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TLR3">TLR3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TLR4">TLR4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TLR9">TLR9</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNC">TNC</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNF">TNF</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFAIP3">TNFAIP3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFAIP6">TNFAIP6</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFAIP6">TNFAIP6</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFRSF11B-O1">TNFRSF11B-O1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFRSF19">TNFRSF19</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFRSF1A">TNFRSF1A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFRSF1B">TNFRSF1B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFSF10">TNFSF10</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFSF11">TNFSF11</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFSF12">TNFSF12</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFSF13B">TNFSF13B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFSF14">TNFSF14</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TNFSF15">TNFSF15</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TP53">TP53</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TREM1">TREM1</a></li><li><a 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Company</label> <input id="company" maxlength="80" name="company" size="20" type="text"></div></div><div class="row"><div class="col-md-12"> <label for="description">Message</label> <textarea name="description"></textarea> </div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <label>Type the characters that you see in the picture below</label> <input type="text" id="PageCaseCaptcha" disabled /> <a class="btnrefresh" onclick="DrawCaptcha();"></a></div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <input type="text" class="case_captcha" id="PageCaseInput" name="case_captcha"/><div id="pagecasecaptcha-error"></div></div></div> <input type="submit" name="submit" style="float:left;" onclick="ValidCaptcha('pagecase');"><div class="clear"></div></form></div></div><div class="needhelp-tab-container tab-pane fade" id="contactinfo"><div class="supportform-con contact-info"><div class="row"><h3>Advanced Cell Diagnostics</h3><p>Our new headquarters office starting May 2016:</p><p>7707 Gateway Blvd. <br />Newark, CA 94560<br />Toll Free: 1 (877) 576-3636<br />Phone: (510) 576-8800<br />Fax: (510) 576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the 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