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Sorensen Lab | Molecular Oncology
<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-VNS5L9E4H7"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-VNS5L9E4H7", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="The overall premise of my research is that a greater understanding of how childhood cancer cells respond to extra- or intracellular signals is necessary to identify tumour-specific pathways. Only then can these pathways be targeted therapeutically in a manner that minimizes effects on normal cells. This is especially important in childhood cancer to avoid toxic effects of treatments on the intellectual, physical, and emotional development of a growing child. An ongoing difficulty with this approach is how to find the relevant pathways to target." /> <link rel="canonical" href="https://www.bccrc.ca/dept/mo/labs/sorensen-lab" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/mo/sites/molecularoncology/files/BCClogo_Research_MolecularOncology_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <link rel="icon" href="/dept/mo/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Sorensen Lab | Molecular Oncology</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_Bxn9zpdS07My99x7G76QyiQFY-SQtLPW6RDCCblqJIQ.css?delta=0&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_b1Imd5Zfo6d9UtggtC_ak93-Ac2c67PnthKR5yWdzt8.css?delta=2&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> </head> <body class="colour--emerald not-front path--node page--lab"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--lab page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/dept/mo/">Molecular Oncology</a> </li> <li> <a href="/dept/mo/labs">Research Labs</a> </li> <li> Sorensen Lab </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Sorensen Lab</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--lab full"> <div class="node__inner"> <footer class="node"> <aside> <a href="/dept/mo/people/poul-sorensen" class="button"><span>Dr. Poul Sorensen, MD, PhD</span> </a> <div class="field field--field_phone_number"><a href="tel:604-675-8202">604-675-8202</a></div> <div class="field field--field_laboratory_contact"> <div class="above field--label">Laboratory Contact</div> <div> <div class="field field--item field--field_laboratory_contact"><article class="node node--profile assistant"> <div class="field--name"> <span>Liheng (Amy) Li</span> </div> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant/Technician</div> </div> </article> </div> </div> </div> <div class="field field--field_admin_contact"> <div class="above field--label">Admin Contact</div> <div> <div class="field field--item field--field_admin_contact"><article class="node node--profile assistant"> <div class="field--name"> <span>Carol Lai</span> </div> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Administrative Coordinator</div> </div> </article> </div> </div> </div> <div class="field field--field_follow_links"> <div class="above field--label">Follow</div> <a href="https://www.twitter.com/bccancer_molonc" target="_blank"><i class="fa fa-twitter"></i></a><a href="https://www.facebook.com/pg/Pathology-and-Laboratory-Medicine-UBC-184608371642999/community/?ref=page_internal" target="_blank"><i class="fa fa-facebook"></i></a> </div> </aside> </footer> <div class="node__main"> <div class="field field--body"><p>The overall premise of my research is that a greater understanding of how childhood cancer cells respond to extra- or intracellular signals is necessary to identify tumour-specific pathways. Only then can these pathways be targeted therapeutically in a manner that minimizes effects on normal cells. This is especially important in childhood cancer to avoid toxic effects of treatments on the intellectual, physical, and emotional development of a growing child. An ongoing difficulty with this approach is how to find the relevant pathways to target. Over the years, we have chosen to characterize recurrent genetic alterations in childhood tumours as a means to more efficiently identify novel cancer genes. This is part of our belief that analysis of primary tumours is preferable for initial identification of pathophysiologically relevant alterations in human malignancies. With the advent of next-generation sequencing, we are now extending this approach to whole genome sequencing of childhood cancers to better understand the mutational landscape of these tumours. Then, once the involved proteins have been identified, model systems can be invoked to further study their biology and how the pathways they are involved in become activated. We then use various biochemical approaches as well as high-throughput platforms such as RNA interference screening to rigorously characterize the involved proteins, their functional interactors, and the signal transduction pathways they participate in. This forms the basis for subsequent strategies to therapeutically target candidate proteins in childhood cancers.</p> <p>Full list of publications may be found <a href="https://www.ncbi.nlm.nih.gov/sites/myncbi/1Jgy56by5_AkJ/bibliography/52413359/public/?sort=date&direction=descending">here</a>.</p></div> </div> </div> </article> <section id="people" class="layout layout__grid"><h2 class="section__title">Members</h2><h3 class="subsection__title">Faculty/Leaders</h3><div class="flexgrid"><article class="node node--profile teaser"> <a class="picture" href="/dept/mo/people/poul-sorensen" ><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-08/DSC00160.jpg?itok=ITnownWp" width="580" height="460" alt="" /> </figure></a> <section> <h3 class="node__title"> <a href="/dept/mo/people/poul-sorensen" rel="bookmark">Dr. Poul Sorensen, MD, PhD</a> </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Distinguished Scientist</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8202">604-675-8202</a></div> <a href= "https://www.bccrc.ca/dept/mo/contact/75" class="more">Send message</a> <a href="/dept/mo/people/poul-sorensen" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> </div><h3 class="subsection__title">Affiliate</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Philipp Lange </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Affiliated Scientist</div> </div> <div class="contact"> </div> </section> </article> </div><h3 class="subsection__title">Staff</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/Cynthia%20Ferguson.jpg?itok=YklNRbtT" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Cynthia Ferguson </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Projects and Operations Leader </div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/mo/contact/155" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2022-06/Yue%20Zhou%20%28Joe%29%20Huang%20Portrait.jpg?itok=2AKsAVtE" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Yue Zhou (Joe) Huang </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant / Technician</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2020-02/MO_ChristopherHughes.jpeg?itok=lJz2lUOZ" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Christopher Hughes </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Mass Spectrometry Service Specialist</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Liheng (Amy) Li </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant/Technician</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Qiaochu (Irene) Lin </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant/Technician</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/MO_MichaelLizardo.jpeg?itok=AqOGsNLw" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Michael Lizardo </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Staff Scientist</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Rouhollah Mousavizadeh </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Associate</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Huijia Qiu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Visiting Scientist</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2022-06/Melanie%20Rouleau.jpeg?itok=To6mLHVt" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Melanie Rouleau </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Project Manager</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/MO_HaifengZhang.jpeg?itok=GBoK3Z_F" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Haifeng Zhang </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Staff Scientist 2</div> </div> <div class="contact"> </div> </section> </article> </div><h3 class="subsection__title">Post-Docs</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2022-07/Alberto%20Delaidelli-min.jpg?itok=QdL9IvFS" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Alberto Delaidelli </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Postdoctoral Fellow</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Ahmed Elbassiouny </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Postdoctoral Fellow</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2022-07/Ashish%20Kumar.jpeg?itok=7wbyYFHK" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Ashish Kumar </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Postdoctoral Fellow</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-11/Renata.jpg?itok=Fh1FAtxm" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Renata Scopim Ribeiro </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Post-doctoral Fellow</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/MO_BusraTurgu_0.jpeg?itok=XiXJUh8B" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Busra Turgu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Postdoctoral Fellow</div> </div> <div class="contact"> </div> </section> </article> </div><h3 class="subsection__title">Students/Trainees</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Fares Burwag </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant/Technician</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Aditya Chauhan </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Directed studies student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Arnold Cheng </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Summer Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Qingfeng Huang </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Visiting Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Qingru Kong </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Directed Studies Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Luxin Liu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Visiting Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Zachary Olarte </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Volunteer</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Jessica Oliveira de Santis </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Visiting Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2020-02/MO_ManideepChowdaryPachva.jpeg?itok=N7v_pTwz" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Manideep Chowdary Pachva </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Ella Poynton </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Co-op Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Annalena Renner </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Constantin Antonio Segner </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Visiting Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <section> <h3 class="node__title"> Mark Sgro </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Co-op Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Namya Sharma </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Co-op Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/MO_TarasShyp.jpeg?itok=R-GL7trs" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Taras Shyp </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Elli Tiliakou </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Volunteer Student</div> </div> <div class="contact"> </div> </section> </article> </div></section> <section id="careers" class="layout layout__expanding layout__careers"><h2 class="section__title">Open Positions</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node node--career expander"> <h2 class="node__title"> <a href="/dept/mo/careers/postdoctoral-research-fellow" rel="bookmark"><span>Postdoctoral Research Fellow</span> </a> </h2> <div class="field field--field_lab"> <div class="field field--item field--field_lab"><a href="/dept/mo/labs/sorensen-lab" hreflang="en">Sorensen Lab</a></div> </div> <button class="icon" data-expand="">+</button> <div class="expanding"> <div class="field field--body"> <p><strong>Job Category</strong></p> <p>Faculty Non Bargaining</p> <p><strong>Job Title</strong></p> <p>Postdoctoral Research Fellow</p> <h3> </h3> <p><strong>Department</strong></p> <p>Sorensen Laboratory | Department of Pathology and Laboratory Medicine | Faculty of Medicine (Poul Sorensen)</p> <h3> </h3> <p><strong>Job description</strong></p> <p>The Sorensen laboratory is seeking a highly-motivated postdoctoral fellow with leadership ability and a strong background in one or more of the following fields, namely molecular biology, immunology, and mouse modeling studies. Expertise in bioinformatics analysis is a definite asset. This is a full-time position under the supervision of Dr. Poul Sorensen at the British Columbia Cancer Research Institute in beautiful Vancouver, British Columbia, part of the University of British Columbia, a consistent top 40 worldwide university. The work focuses on functional characterization of pathways involved in tumor cell adaptation to diverse stresses of the tumor microenvironment (TME), including metabolic stress, and how such adaptation leads to disease progression, in high-risk childhood cancers (e.g. PMIDs: 34021002; 35365367; 37611092; 25965573; 31668005; 33908607; 32406909; 25800057). The goal is to use this information to identify and implement novel therapies, including immunotherapeutic targets, for the treatment of these diseases, including Ewing sarcoma, osteosarcoma, neuroblastoma, and CNS tumors. The position start date is flexible but is available immediately for the successful candidate.</p> <p>This position is located within a health-care facility. Therefore, this position requires successful verification of full vaccination against Covid-19 provided prior to the start date, as required by the provincial health mandate.</p> <p><strong>Job summary</strong></p> <p>The work performed in the Sorensen laboratory seeks to utilize basic science approaches to uncover new treatment options in high-risk pediatric cancers, particularly in the targeting of metastatic disease.</p> <p>The topic areas include but are not limited to the following;</p> <ul> <li>utilizing proteomics, especially surfaceomic analysis, to identify novel immunotherapy targets for the development of antibody-based therapies in the treatment of high-risk pediatric cancers;</li> <li>extensive use of <em>in vitro </em>and <em>in vivo</em> CRISPR screening to identify and functionally validate high-value pathways of interest from multi-omic studies;</li> <li>therapeutic targeting of altered metabolic pathways in pediatric cancers;</li> <li>elucidation of mechanisms of tumor cell stress adaptation in the TME, including metabolic reprogramming, and how this confers metastatic competence; and</li> <li>the role of RNA binding proteins, stress granules, and altered mRNA translation in tumor cytoprotective responses.</li> </ul> <p>Moreover, this position will provide opportunities to collaborate with international leaders in the field of pediatric basic, translational, and clinical research, including immunotherapy and antibody engineering. The selected fellow will initially be supported by grant funds, but will be strongly encouraged to apply for independent fellowship funding, and existing funding is of course an asset.</p> <p><strong>Organizational status</strong></p> <p>The PDF will be employed by the department of Pathology and Laboratory Medicine, Faculty of Medicine at the University of British Columbia. The Sorensen Laboratory is located at the BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to the primary Investigator, Dr. Sorensen. The position requires to use a high degree of leadership, initiative, tact and professional judgement in carrying out responsibilities related to the research. Excellent writing skills are critical.</p> <p>The Department of Pathology and Laboratory Medicine at UBC is a hybrid, academically intensive Department within the UBC Faculty of Medicine whose activities span a broad spectrum of teaching, research, and academic service, often performed in the milieu of clinical practice, and are ultimately devoted to improving the care, treatment, and well-being of patients. The Department offers academic degrees at the bachelor’s (Bachelor of Medical Laboratory Science (BMLSc)) and graduate (MSc, PhD) levels with the graduate program, one of the largest in the Faculty of Medicine, which has been recognized by UBC for its quality. The Department plays a major role in the MD undergraduate program and offers an accredited residency-training program. Faculty members participate across a spectrum of research from basic investigative to translational to clinical applied research and are recognized locally, nationally and internationally for their excellence. </p> <p><strong>Work performed</strong></p> <ul> <li>Develop and implement research plan to validate and prioritize therapeutic targets in high-risk childhood cancers, based on omics data, including surfaceomic data.</li> <li>Provide leadership, strategic direction, and translational research pertaining to the development of novel immunotherapy for the treatment of high-risk childhood cancers</li> <li>Design and conduct animal experiments, molecular and cellular biology analysis, and bioinformatics analysis of CRISPR screening and other omics experiments. </li> <li>Prepare and present results at internal and external meetings and write manuscripts for publication in peer-reviewed journals.</li> <li>Identify funding opportunities as well as write grant proposals</li> <li>Lead and mentor junior trainees/students in the laboratory</li> </ul> <p><strong>Consequence of Error/Judgement</strong></p> <p>This is a senior research position with a critical role in the development of this emerging field. The PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.</p></div> <div class="field field--field_application_link"><a href="https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/details/Postdoctoral-Research-Fellow_JR14638">Apply online now</a></div> </div> </article> </div></section> <section id="publications" class="layout layout__expanding layout__publications"><h2 class="section__title">Selected Publications</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37846480" target="_blank" rel="bookmark"><span>The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes</span> </a> </h2> <div class="field field--field_journal">EMBO reports</div> <div class="field field--field_authors">Turgu B, El-Naggar A, Kogler M, Tortola L, Zhang HF, Hassan M, Lizardo MM, Kung SH, Lam W, Penninger JM, Sorensen PH</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37846480" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37812652" target="_blank" rel="bookmark"><span>Surface and global proteome analyses identify ENPP1 and other surface proteins as actionable immunotherapeutic targets in Ewing sarcoma</span> </a> </h2> <div class="field field--field_journal">Clinical Cancer Research</div> <div class="field field--field_authors">Mooney B, Negri GL, Shyp T, Delaidelli A, Zhang HF, Spencer Miko SE, Weiner AK, Radaoui AB, Shraim R, Lizardo MM, Hughes CS, Li A, El-Naggar AM, Rouleau M, Li W, Dimitrov DS, Kurmasheva RT, Houghton PJ, Diskin SJ, Maris JM, Morin GB, Sorensen PH</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37812652" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37611092" target="_blank" rel="bookmark"><span>A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma</span> </a> </h2> <div class="field field--field_journal">Science Advances</div> <div class="field field--field_authors">Zhang HF, Delaidelli A, Javed S, Turgu B, Morrison T, Hughes CS, Yang X, Pachva M, Lizardo MM, Singh G, Hoffmann J, Huang YZ, Patel K, Shraim R, Kung SHY, Morin GB, Aparicio S, Martinez D, Maris JM, Bosse KR, Williams KC, Sorensen PH</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/37611092" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/34021002" target="_blank" rel="bookmark">Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma.</a> </h2> <div class="field field--field_journal">Cancer discovery, 2021</div> <div class="field field--field_authors">Zhang, Hai-Feng, Hughes, Christopher S, Li, Wei, He, Jian-Zhong, Surdez, Didier, El-Naggar, Amal M, Cheng, Hongwei, Prudova, Anna, Delaidelli, Alberto, Negri, Gian Luca, Li, Xiaojun, Ørum-Madsen, Maj Sofie, Lizardo, Michael M, Oo, Htoo Zarni, Colborne, Shane, Shyp, Taras, Scopim-Ribeiro, Renata, Hammond, Colin A, Dhez, Anne-Chloe, Langman, Sofya, Lim, Jonathan K M, Kung, Sonia H Y, Li, Amy, Steino, Anne, Daugaard, Mads, Parker, Seth J, Geltink, Ramon I Klein, Orentas, Rimas J, Xu, Li-Yan, Morin, Gregg B, Delattre, Olivier, Dimitrov, Dimiter S, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/34021002" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31668005" target="_blank" rel="bookmark">Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.</a> </h2> <div class="field field--field_journal">EMBO reports, 2019</div> <div class="field field--field_authors">El-Naggar, Amal M, Somasekharan, Syam Prakash, Wang, Yemin, Cheng, Hongwei, Negri, Gian Luca, Pan, Melvin, Wang, Xue Qi, Delaidelli, Alberto, Rafn, Bo, Cran, Jordan, Zhang, Fan, Zhang, Haifeng, Colborne, Shane, Gleave, Martin, Mandinova, Anna, Kedersha, Nancy, Hughes, Christopher S, Surdez, Didier, Delattre, Olivier, Wang, Yuzhuo, Huntsman, David G, Morin, Gregg B, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31668005" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31236944" target="_blank" rel="bookmark">Integrative genomic analysis of matched primary and metastatic pediatric osteosarcoma.</a> </h2> <div class="field field--field_journal">The Journal of pathology, 2019</div> <div class="field field--field_authors">Negri, Gian Luca, Grande, Bruno M, Delaidelli, Alberto, El-Naggar, Amal, Cochrane, Dawn, Lau, Ching C, Triche, Timothy J, Moore, Richard A, Jones, Steven Jm, Montpetit, Alexandre, Marra, Marco A, Malkin, David, Morin, Ryan D, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31236944" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31000598" target="_blank" rel="bookmark">Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance.</a> </h2> <div class="field field--field_journal">Proceedings of the National Academy of Sciences of the United States of America, 2019</div> <div class="field field--field_authors">Lim, Jonathan K M, Delaidelli, Alberto, Minaker, Sean W, Zhang, Hai-Feng, Colovic, Milena, Yang, Hua, Negri, Gian Luca, von Karstedt, Silvia, Lockwood, William W, Schaffer, Paul, Leprivier, Gabriel, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31000598" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28574509" target="_blank" rel="bookmark">MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.</a> </h2> <div class="field field--field_journal">Cell death and differentiation, 2017</div> <div class="field field--field_authors">Delaidelli, Alberto, Negri, Gian Luca, Jan, Asad, Jansonius, Brandon, El-Naggar, Amal, Lim, Jonathan K M, Khan, Debjit, Oo, Htoo Zarni, Carnie, Christopher J, Remke, Marc, Maris, John M, Leprivier, Gabriel, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28574509" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/27752775" target="_blank" rel="bookmark">eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.</a> </h2> <div class="field field--field_journal">Acta neuropathologica, 2017</div> <div class="field field--field_authors">Jan, Asad, Jansonius, Brandon, Delaidelli, Alberto, Somasekharan, Syam Prakash, Bhanshali, Forum, Vandal, Milène, Negri, Gian Luca, Moerman, Don, MacKenzie, Ian, Calon, Frédéric, Hayden, Michael R, Taubert, Stefan, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27752775" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/26461094" target="_blank" rel="bookmark">Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.</a> </h2> <div class="field field--field_journal">Cancer cell, 2015</div> <div class="field field--field_authors">Salanti, Ali, Clausen, Thomas M, Agerbæk, Mette Ø, Al Nakouzi, Nader, Dahlbäck, Madeleine, Oo, Htoo Zarni, Lee, Sherry, Gustavsson, Tobias, Rich, Jamie R, Hedberg, Bradley J, Mao, Yang, Barington, Line, Pereira, Marina A, LoBello, Janine, Endo, Makoto, Fazli, Ladan, Soden, Jo, Wang, Chris K, Sander, Adam F, Dagil, Robert, Thrane, Susan, Holst, Peter J, Meng, Le, Favero, Francesco, Weiss, Glen J, Nielsen, Morten A, Freeth, Jim, Nielsen, Torsten O, Zaia, Joseph, Tran, Nhan L, Trent, Jeff, Babcook, John S, Theander, Thor G, Sorensen, Poul H, Daugaard, Mads</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/26461094" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/25965573" target="_blank" rel="bookmark">Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.</a> </h2> <div class="field field--field_journal">Cancer cell, 2015</div> <div class="field field--field_authors">El-Naggar, Amal M, Veinotte, Chansey J, Cheng, Hongwei, Grunewald, Thomas G P, Negri, Gian Luca, Somasekharan, Syam Prakash, Corkery, Dale P, Tirode, Franck, Mathers, Joan, Khan, Debjit, Kyle, Alastair H, Baker, Jennifer H, LePard, Nancy E, McKinney, Steven, Hajee, Shamil, Bosiljcic, Momir, Leprivier, Gabriel, Tognon, Cristina E, Minchinton, Andrew I, Bennewith, Kevin L, Delattre, Olivier, Wang, Yuzhuo, Dellaire, Graham, Berman, Jason N, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/25965573" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/25800057" target="_blank" rel="bookmark">YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.</a> </h2> <div class="field field--field_journal">The Journal of cell biology, 2015</div> <div class="field field--field_authors">Somasekharan, Syam Prakash, El-Naggar, Amal, Leprivier, Gabriel, Cheng, Hongwei, Hajee, Shamil, Grunewald, Thomas G P, Zhang, Fan, Ng, Tony, Delattre, Olivier, Evdokimova, Valentina, Wang, Yuzhuo, Gleave, Martin, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/25800057" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/23706743" target="_blank" rel="bookmark">The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.</a> </h2> <div class="field field--field_journal">Cell, 2013</div> <div class="field field--field_authors">Leprivier, Gabriel, Remke, Marc, Rotblat, Barak, Dubuc, Adrian, Mateo, Abigail-Rachele F, Kool, Marcel, Agnihotri, Sameer, El-Naggar, Amal, Yu, Bin, Somasekharan, Syam Prakash, Faubert, Brandon, Bridon, Gaëlle, Tognon, Cristina E, Mathers, Joan, Thomas, Ryan, Li, Amy, Barokas, Adi, Kwok, Brian, Bowden, Mary, Smith, Stephanie, Wu, Xiaochong, Korshunov, Andrey, Hielscher, Thomas, Northcott, Paul A, Galpin, Jason D, Ahern, Christopher A, Wang, Ye, McCabe, Martin G, Collins, V Peter, Jones, Russell G, Pollak, Michael, Delattre, Olivier, Gleave, Martin E, Jan, Eric, Pfister, Stefan M, Proud, Christopher G, Derry, W Brent, Taylor, Michael D, Sorensen, Poul H</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/23706743" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/19411069" target="_blank" rel="bookmark">Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition.</a> </h2> <div class="field field--field_journal">Cancer cell, 2009</div> <div class="field field--field_authors">Evdokimova, Valentina, Tognon, Cristina, Ng, Tony, Ruzanov, Peter, Melnyk, Natalya, Fink, Dieter, Sorokin, Alexey, Ovchinnikov, Lev P, Davicioni, Elai, Triche, Timothy J, Sorensen, Poul H B</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/19411069" target="_blank">Learn More</a></div> </article> </div></section> <section id="projects" class="layout layout__expanding layout__projects"><h2 class="section__title">Projects</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node node--project teaser"> <div class="node__inner"> <h2 class="node__title"> <a href="/dept/mo/projects/discovery-and-development-optimal-immunotherapeutic-strategies-childhood-cancers" rel="bookmark" ><span>Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers</span> </a> </h2> <div class="field field--body"><p>High-risk pediatric cancers remain the leading cause of mortality in childhood, and current standard approaches to treat pediatric cancers frequently induce unacceptable life-long morbidity. This multi-center collaborative effort focuses on identifying and understanding the fundamental mechanisms leading to high-risk childhood cancers, including how these malignancies evolve to evade the immune system and resist modern therapies.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/mo/projects/discovery-and-development-optimal-immunotherapeutic-strategies-childhood-cancers" rel="tag" title="Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers" hreflang="en">More Info<span class="visually-hidden"> about Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers</span></a></li></ul> </div> </article> <article class="node node--project teaser"> <div class="node__inner"> <h2 class="node__title"> <a href="/dept/mo/projects/immunogenomics-create-new-therapies-high-risk-childhood-cancers" rel="bookmark" ><span>Immunogenomics to Create New Therapies for High-Risk Childhood Cancers</span> </a> </h2> <div class="field field--body"><p>The St. Baldrick's Foundation – SU2C Pediatric Cancer Dream Team is a collaboration between pediatric cancer researchers in the largely disparate disciplines of cancer genomics and immunotherapeutics. The team will focus on developing new, targeted immunotherapeutics for the most difficult-to-cure childhood cancers.</p></div> <ul class="links inline"><li class="node-readmore"><a href="/dept/mo/projects/immunogenomics-create-new-therapies-high-risk-childhood-cancers" rel="tag" title="Immunogenomics to Create New Therapies for High-Risk Childhood Cancers" hreflang="en">More Info<span class="visually-hidden"> about Immunogenomics to Create New Therapies for High-Risk Childhood Cancers</span></a></li></ul> </div> </article> </div></section> <section class="has-logos layout layout__sponsors"> <h2 class="section__title">Sponsors</h2> <div class="flexgrid"> <div class="field--item field--field_sponsors"><a href="http://www.cihr-irsc.gc.ca/e/193.html" target="_blank"> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/square_logo/public/2019-08/leaf-cihr-colour-en_0.jpg?itok=6rRZE4fK" width="200" height="129" alt="" /> </a></div> <div class="field--item field--field_sponsors"><a href="http://www.cancer.ca/en/?region=bc" target="_blank"> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/square_logo/public/2019-08/CCS%20Logo.png?itok=XUOO-5B5" width="145" height="53" alt="" /> </a></div> <div class="field--item field--field_sponsors"><a href="https://www.tfri.ca/" target="_blank"> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/square_logo/public/2019-08/TFRI%20Logo.png?itok=wwW6XwFW" width="200" height="32" alt="" /> </a></div> <div class="field--item field--field_sponsors"><a href="https://www.stbaldricks.org/" target="_blank"> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/square_logo/public/2019-08/St%20Baldrick%27s%20Foundation.png?itok=1fbIy5yr" width="200" height="200" alt="" /> </a></div> <div class="field--item field--field_sponsors"><a href="https://bccancerfoundation.com/" target="_blank"> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/square_logo/public/2019-08/bccf-logo.png?itok=4-36ljEN" width="200" height="115" alt="" /> </a></div> <div class="field--item field--field_sponsors"><a href="https://standuptocancer.org/" target="_blank"> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/square_logo/public/2019-08/SU2C%20Logo.png?itok=-nWCbt2I" width="200" height="155" alt="" /> </a></div> </div> </section> </section> </div> </section> </div> <a class="top" href="#main-content">Back to top</a> </main> <section class="region region__cta"> <div class="region__cta--inner region--inner"> <section id="block-sitecalltoaction" class="block block--block-contenta8a59224-4648-42d5-b71c-294b3c630d8a block-sitecalltoaction"> <div class="field field--body"><p>BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. 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