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Understanding these processes may provide insight into potential therapeutic targets against the diseases caused by these parasites."},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Tardieux \u0026 Baum J.Cell Biol.- 2016.pdf","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [51900292]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":48995359,"attachmentType":"pdf"}"><img alt="First page of “Tardieux & Baum J.Cell Biol.- 2016.pdf”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/48995359/mini_magick20220706-14283-pyognf.png?1657096367" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Tardieux & Baum J.Cell Biol.- 2016.pdf</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="51900292" href="https://cnrs.academia.edu/IsabelleTardieux"><img alt="Profile image of Isabelle Tardieux" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/51900292/13741460/121136131/s65_isabelle.tardieux.jpg" />Isabelle Tardieux</a></div><div class="ds-work-card--detail"><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">9 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 28630437; 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This research primarily explores the underlying mechanisms of apicomplexan zoite cell invasion, focusing on the cellular structures critical for motility and the signaling pathways engaged during infection. 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Although the TJ was first described decades ago, its molecular characterization has proved difficult mainly because of its transient existence during an internalization process that lasts only seconds. In the past 7 years, work has led to a model of the TJ in which the association between AMA1 and RON proteins structures the TJ and bridges the cytoskeletons of the two cells. However, more recent work questions this view. Here, we critically discuss the current model and speculate on alternative models of the AMA1-RON association and of the apicomplexan TJ.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Host cell invasion by apicomplexans: what do we know?","attachmentId":47991310,"attachmentType":"pdf","work_url":"https://www.academia.edu/27721374/Host_cell_invasion_by_apicomplexans_what_do_we_know","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27721374/Host_cell_invasion_by_apicomplexans_what_do_we_know"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="14100549" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14100549/Host_cell_invasion_by_malaria_parasites_insights_from_Plasmodium_and_Toxoplasma">Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33106564" href="https://uni-heidelberg.academia.edu/FriedrichFrischknecht">Friedrich Frischknecht</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Trends in Parasitology, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">Recent years have seen tremendous progress in our understanding of malaria parasite molecular biology. To a large extent, this progress follows significant developments in genetic, molecular and chemical tools available to study the malaria parasites and related Apicomplexa, in particular Toxoplasma gondii. One area of major advancement has been in understanding parasite host-cell invasion, a process that utilizes several essential molecular mechanisms that are conserved across the different lifecycle stages. Here, we summarize some of the most recent experimental data that shed light on the events underlying preparation and execution of malaria parasite invasion and how these insights might relate to the development of new antimalarial drugs.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma","attachmentId":44604315,"attachmentType":"pdf","work_url":"https://www.academia.edu/14100549/Host_cell_invasion_by_malaria_parasites_insights_from_Plasmodium_and_Toxoplasma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14100549/Host_cell_invasion_by_malaria_parasites_insights_from_Plasmodium_and_Toxoplasma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="22217657" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22217657/Host_Cell_Entry_by_Apicomplexa_Parasites_Requires_Actin_Polymerization_in_the_Host_Cell">Host Cell Entry by Apicomplexa Parasites Requires Actin Polymerization in the Host Cell</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43579341" href="https://independent.academia.edu/IsabelleTardieux">Isabelle Tardieux</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43874037" href="https://independent.academia.edu/violainewalker">violaine walker</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cell Host & Microbe, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Host Cell Entry by Apicomplexa Parasites Requires Actin Polymerization in the Host Cell","attachmentId":42870567,"attachmentType":"pdf","work_url":"https://www.academia.edu/22217657/Host_Cell_Entry_by_Apicomplexa_Parasites_Requires_Actin_Polymerization_in_the_Host_Cell","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/22217657/Host_Cell_Entry_by_Apicomplexa_Parasites_Requires_Actin_Polymerization_in_the_Host_Cell"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="8570091" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8570091/Conservation_of_a_Gliding_Motility_and_Cell_Invasion_Machinery_in_Apicomplexan_Parasites">Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="17677608" href="https://educ.academia.edu/YUDAWAN">YUDA WAN</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cell Biology, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">Most Apicomplexan parasites, including the human pathogens Plasmodium , Toxoplasma , and Cryptosporidium , actively invade host cells and display gliding motility, both actions powered by parasite microfilaments. 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ds2-5-body-link" data-author-id="52018496" href="https://independent.academia.edu/DanielBargieri">Daniel Bargieri</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLoS Pathogens, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Host Cell Invasion by Apicomplexan Parasites: The Junction Conundrum","attachmentId":42870572,"attachmentType":"pdf","work_url":"https://www.academia.edu/22217669/Host_Cell_Invasion_by_Apicomplexan_Parasites_The_Junction_Conundrum","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/22217669/Host_Cell_Invasion_by_Apicomplexan_Parasites_The_Junction_Conundrum"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="117959544" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117959544/Motile_Systems_in_Malaria_Merozoites_How_is_the_Red_Blood_Cell_Invaded">Motile Systems in Malaria Merozoites: How is the Red Blood Cell Invaded?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="304777102" href="https://independent.academia.edu/LawrenceBannister2">Lawrence Bannister</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Parasitology Today, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Motile Systems in Malaria Merozoites: How is the Red Blood Cell Invaded?","attachmentId":113695216,"attachmentType":"pdf","work_url":"https://www.academia.edu/117959544/Motile_Systems_in_Malaria_Merozoites_How_is_the_Red_Blood_Cell_Invaded","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/117959544/Motile_Systems_in_Malaria_Merozoites_How_is_the_Red_Blood_Cell_Invaded"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="18156019" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18156019/Cytoskeleton_of_Apicomplexan_Parasites">Cytoskeleton of Apicomplexan Parasites</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38120897" href="https://independent.academia.edu/NaomiMorrissette">Naomi Morrissette</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Microbiology and Molecular Biology Reviews, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytoskeleton of Apicomplexan Parasites","attachmentId":39905180,"attachmentType":"pdf","work_url":"https://www.academia.edu/18156019/Cytoskeleton_of_Apicomplexan_Parasites","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/18156019/Cytoskeleton_of_Apicomplexan_Parasites"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="22709895" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22709895/Migration_through_host_cells_by_apicomplexan_parasites">Migration through host cells by apicomplexan parasites</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44333445" href="https://independent.academia.edu/AnaRodriguez251">Ana Rodriguez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Microbes and Infection, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">In what appears to be an essential prelude to establish a successful infection in the mammalian host, Plasmodium sporozoites move rapidly through several host cells breaching the cell plasma membranes in the process. This mode of invasion precedes the 'traditional' mode in which the sporozoite enters by invagination of the host cell membrane and develops within a parasitophorous vacuole. Here we revisit the existing literature that supports the presence of similar invasive behaviors in other apicomplexan parasites. © 2001 Éditions scientifiques et médicales Elsevier SAS Plasmodium / Apicomplexa / migration / Toxoplasma / Eimeria</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Migration through host cells by apicomplexan parasites","attachmentId":43282964,"attachmentType":"pdf","work_url":"https://www.academia.edu/22709895/Migration_through_host_cells_by_apicomplexan_parasites","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/22709895/Migration_through_host_cells_by_apicomplexan_parasites"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="13839296" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13839296/Plasmodium_sporozoite_invasion_into_insect_and_mammalian_cells_is_directed_by_the_same_dual_binding_system">Plasmodium sporozoite invasion into insect and mammalian cells is directed by the same dual binding system</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32931584" href="https://independent.academia.edu/VNussenzweig">V. Nussenzweig</a></div><p class="ds-related-work--metadata ds2-5-body-xs">EMBO Journal, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Plasmodium sporozoite invasion into insect and mammalian cells is directed by the same dual binding system","attachmentId":44892927,"attachmentType":"pdf","work_url":"https://www.academia.edu/13839296/Plasmodium_sporozoite_invasion_into_insect_and_mammalian_cells_is_directed_by_the_same_dual_binding_system","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13839296/Plasmodium_sporozoite_invasion_into_insect_and_mammalian_cells_is_directed_by_the_same_dual_binding_system"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":48995359,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":48995359,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_48995359" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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