Cardiovascular Clinical Research Trials

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The need to discover and develop better, safer and more cost-effective drugs and devices remains.</p> <p>ICON, a full-service provider, takes a data-driven approach to develop strategies that will cut timelines and costs from First-in-Human (FIH) studies through post-approval. We have over 25 years of experience conducting cardiovascular trials with particular emphasis on key cardiovascular/metabolic indications: heart failure, lipid disorders, diabetes, renal insufficiency and renal transplant, arrhythmia, and rare diseases.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="50c183b2-1260-4592-8616-2c23a4218bad" class="icon-group icon-group--horizontal"> <div class="container-fluid container-fluid--xl"> <h2 class="icon-group__title">ICON Cardiovascular experience in the last five years</h2> <ul class="icon-group__items icon-group__items__columns-3"> <li class="icon-group__item--green-bright"> <div lang="en" class="icon-group__wrapper" > <i class="icon-partnership-2"></i> <p class="mb-2 icons-large-text">36,415</p> <small>Patients</small> </div> </li> <li class="icon-group__item--blue"> <div lang="en" class="icon-group__wrapper" > <i class="icon-report"></i> <p class="mb-2 icons-large-text">118</p> <small>Studies</small> </div> </li> <li class="icon-group__item--blue-light"> <div lang="en" class="icon-group__wrapper" > <i class="icon-global"></i> <p class="mb-2 icons-large-text">3,929</p> <small>Sites</small> </div> </li> </ul> </div> </div> <div id="6dd50246-f45a-4316-8bb6-1eb480a3d8fe"> <div class="group bg-white"> <div class="container-fluid container-fluid--xl"> <h2 class="group__title"> ICON's experienced cardio-metabolic drug and medical device development teams support clinical trials across multiple indications, including: </h2> <p class="group__text"> </p> <ul class="row card-list"> <li> <div class="card card--overlapping-img text-left card--overlapping-img-blue"> <div class="image image--zoom-on-hover"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=sJD9q9mW 1x, https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=CHqsd-_Y 2x" media="(min-width: 1400px)" width="370" height="194"/> <source srcset="https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=sJD9q9mW 1x, https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=CHqsd-_Y 2x" media="(min-width: 1200px)" width="370" height="194"/> <source srcset="https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=CSH5jn6a 1x, https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=281&h=194&a=45,0&itok=mS9GDKXh 2x" media="(min-width: 992px) and (max-width: 1199px)" width="301" height="158"/> <source srcset="https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=193&a=0,1&itok=_RHPclmu 1x, https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=193&a=0,1&itok=HA8RM_0f 2x" media="(min-width: 768px) and (max-width: 991px)" width="226" height="118"/> <source srcset="https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=rkY-8cNT 1x, https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=bLMbKIjJ 2x" media="(min-width: 576px) and (max-width: 767px)" width="400" height="210"/> <source srcset="https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=BzOJjW6F 1x, https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=CjDMKVKA 2x" media="(max-width: 575px)" width="400" height="210"/> <img src="https://icon.widen.net/content/niblglo3wm/web/therapeutics-cardiovascular.jpg?crop=yes&w=370&h=194&a=0,0&itok=BzOJjW6F" width="400" height="210" alt="therapeutics-cardiovascular" title="therapeutics-cardiovascular" loading="lazy" /> </picture> </div> </div> </div> <div class="card-body overlapping-comp" data-mh="card-body"> <h4 class="card-title">Cardiovascular</h4> <div class="card-text small"> <div> <ul> <li>Atrial and Ventricular Arrhythmia</li> <li>Cardiomyopathy (e.g., ATTR, hypertrophic, etc. with rare disease team)</li> <li>Heart failure</li> <li>Hypertension</li> <li>Pulmonary Hypertension (with the respiratory team)</li> <li>Coronary Artery Disease and Stable Angina</li> <li>Acute Coronary syndromes, including myocardial infarction</li> <li>Venous Thromboembolism</li> <li>Peripheral Arterial Disease</li> </ul> </div> </div> </div> </div> </li> <li> <div class="card card--overlapping-img text-left card--overlapping-img-purple"> <div class="image image--zoom-on-hover"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=hqGL68Iy 1x, https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=4qymBJxb 2x" media="(min-width: 1400px)" width="370" height="194"/> <source srcset="https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=hqGL68Iy 1x, https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=4qymBJxb 2x" media="(min-width: 1200px)" width="370" height="194"/> <source srcset="https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=lthzFLxj 1x, https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=281&h=194&a=45,0&itok=H0IxfZcQ 2x" media="(min-width: 992px) and (max-width: 1199px)" width="301" height="158"/> <source srcset="https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=193&a=0,1&itok=Av8x1iN7 1x, https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=193&a=0,1&itok=ALaCqLtK 2x" media="(min-width: 768px) and (max-width: 991px)" width="226" height="118"/> <source srcset="https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=v7cy3yVQ 1x, https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=M1WxFvzq 2x" media="(min-width: 576px) and (max-width: 767px)" width="400" height="210"/> <source srcset="https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=VTPJkRSn 1x, https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=_3Vq8n1K 2x" media="(max-width: 575px)" width="400" height="210"/> <img src="https://icon.widen.net/content/4xchdcykmh/web/central-nervous-system-graphic.jpg?crop=yes&w=370&h=194&a=0,0&itok=VTPJkRSn" width="400" height="210" alt="central-nervous-system-graphic" title="central-nervous-system-graphic" loading="lazy" /> </picture> </div> </div> </div> <div class="card-body overlapping-comp" data-mh="card-body"> <h4 class="card-title">Atherosclerotic & embolic cerebrovascular disease</h4> <div class="card-text small"> <div> <ul> <li>Stroke, TIA (with neurosciences team)</li> </ul> </div> </div> </div> </div> </li> <li> <a href="/therapeutics/endocrine-metabolic-disorders" class="block-link" target="_self"> <div class="card card--overlapping-img text-left card--overlapping-img-gray"> <div class="image image--zoom-on-hover"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/jjhx6hqkdb/web/Firecrest.jpg?crop=yes&w=200&h=105&a=0,1&itok=bqDTshRL 1x, https://icon.widen.net/content/jjhx6hqkdb/web/Firecrest.jpg?crop=yes&w=200&h=105&a=0,1&itok=_0PMyzHb 2x" media="(min-width: 1400px)" width="370" height="194"/> <source srcset="https://icon.widen.net/content/jjhx6hqkdb/web/Firecrest.jpg?crop=yes&w=200&h=105&a=0,1&itok=bqDTshRL 1x, 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data-responsive-background-lg="https://icon.widen.net/content/23d8066a-f129-42d9-b69b-d1a88dd94697/web/ipad-and-test-tubes-2.jpg?crop=yes&w=1392&h=523&a=0,203&itok=j0xrVvPv" data-responsive-background-md="https://icon.widen.net/content/23d8066a-f129-42d9-b69b-d1a88dd94697/web/ipad-and-test-tubes-2.jpg?crop=yes&w=1227&h=928&a=83,0&itok=PhZx-QSl" class="area__content-item has-link" id="area-item-7-142027-131798" href="/solutions/laboratories/global-central-laboratories" target="_self"> <div class="area__content-item-overlay area__content-item-overlay--green-dark"></div> <h3 class="area__content-item-title">Central Laboratories</h3> <p class="area__content-item-description">Global central laboratories with industry-leading accuracy for CVM study endpoints.</p> <div class="btn btn-outline-white">Explore</div> </a> </div> </div> </div> </div> </div> <div id="ff123c16-b021-4be3-92ff-19668b4b9e3b"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> </h3> <div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="41570165-43a3-4bfb-a416-84cb27bf0914"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> Dedicated specialist teams </h3> <div> <p>ICON has a global team of in-house cardio-metabolic experts who are highly-experienced in clinical research and drug and device development. The group includes representatives from all critical functional areas and oversees trial operations in order to anticipate and proactively address potential roadblocks. We also leverage established and new relationships with renowned cardio-metabolic experts and investigators worldwide to benefit our clients.</p> <p>In addition to providing support and guidance to the study team, our cardio-metabolic experts provide insight on:</p> <ul> <li>Global project feasibility</li> <li>Protocol development, review and evaluation</li> <li>Clinical trial planning</li> <li>Therapeutic training and advice</li> <li>Project oversight</li> <li>Consulting, medical monitoring and advisory board representation</li> <li>Interpretation of the clinical data</li> <li>Completion of the clinical study report</li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="25ec403e-8ed5-4dd2-a156-3de684616146"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h2>Accellacare</h2> <h3> </h3> <div> <p>Our global investigator database includes over 5,800 cardiovascular investigative sites across more than 55 countries. As such, we have established solid working relationships with leading cardiovascular sites in all regions of the world, enabling us to provide our sponsors with efficient recruitment strategies tailored to each study.</p> </div> <a class="btn btn-primary btn-md" href="https://accellacare.com/" target="_blank">Learn more</a> </div> </div> </div> </div> </div> </div> </div> </div> <div id="4be9c05a-c64f-4448-a737-bda8302c1efc"> <div class="bg-gray"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h2>Cardiovascular, Metabolic and Circulation insights </h2> <h3> </h3> <div> <p>ICON's Cardiovascular team contributes regularly to industry publications and media coverage of cardiovascular clinical trials. Stay up to date with ICON's latest thought leadership on cardiovascular clinical trials.</p> </div> <a class="btn btn-primary btn-md" href="/insights/therapeutics/cardiovascular" target="_self">Read more </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </second> </div> <div class="col-md-3 order-1"> <div id="f0c1f845-b525-4f76-b427-fbdc9c67231c"> <div class="container-fluid container-fluid--xl sidebar-menu-wrapper"> <div class="sidebar"> <div class="sidebar sidebar--sticky sidebar--collapsible"> <a class="sidebar--collapsible__toggle collapsed" role="button" data-toggle="collapse" href="#sidebar-content" aria-expanded="false" aria-controls="sidebar-content"> <span>In this section</span> </a> <div class="sidebar--collapsible__content collapse" id="sidebar-content"> <div class="sidebar--menu"> <h6 class="d-none d-md-block">In this section</h6> <ul class="sidebar--collapsible__list"> <li> <a href="/therapeutics/biosimilars" 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therapies</a> <div class="collapse " id="cell-and-gene-therapies-the-affordability-hurdle-for-gene-therapies-10513" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#central-nervous-system-10514"></span> <a href="/therapeutics/central-nervous-system" data-drupal-link-system-path="node/34071">Central Nervous System</a> <div class="collapse " id="central-nervous-system-10514" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/central-nervous-system/cns-neurology" data-drupal-link-system-path="node/34068">CNS Neurology</a> <div class="collapse " id="central-nervous-system-cns-neurology-10515" > </div> </li> <li> <a href="/therapeutics/central-nervous-system/cns-pain" data-drupal-link-system-path="node/34069">CNS Pain</a> <div class="collapse " id="central-nervous-system--cns-pain-10516" > </div> </li> <li> <a 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href="/insights/therapeutics/central-nervous-system/key-considerations-in-chronic-pain-clinical-trials" data-drupal-link-system-path="node/33681">Key considerations in chronic pain clinical trials</a> <div class="collapse " id="central-nervous-system------key-considerations-in-chronic-pain-clinical-trials-10520" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#endocrine-metabolic-disorders-10521"></span> <a href="/therapeutics/endocrine-metabolic-disorders" data-drupal-link-system-path="node/34072">Endocrine & Metabolic Disorders</a> <div class="collapse " id="endocrine-metabolic-disorders-10521" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/endocrine-metabolic-disorders/obesity" data-drupal-link-system-path="node/38991">Obesity</a> <div class="collapse " id="endocrine-metabolic-disorders-obesity-11021" > </div> </li> <li class="sidebar--submenu"> <span 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<a href="/insights/therapeutics/rare-and-orphan-diseases/leveraging-historical-data-for-use-in-rare-disease-trials" data-drupal-link-system-path="node/33707">Leveraging historical data for use in rare disease trials</a> <div class="collapse " id="rare-orphan-diseases-leveraging-historical-data-for-use-in-rare-disease-trials-10542" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/patient-centricity-in-orphan-drug-development" data-drupal-link-system-path="node/33709">Patient centricity in orphan drug development</a> <div class="collapse " id="rare-orphan-diseases--patient-centricity-in-orphan-drug-development-10543" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#vaccines-10546"></span> <a href="/therapeutics/vaccines" data-drupal-link-system-path="node/34092">Vaccines</a> <div class="collapse " id="vaccines-10546" > <ul class="menu 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</div> </li> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/mainstreaming-cell-gene-therapies" data-drupal-link-system-path="node/33676">Mainstreaming Cell & Gene Therapies</a> <div class="collapse " id="cell-and-gene-therapies----mainstreaming-cell-gene-therapies-10555" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights---central-nervous-system-10556"></span> <a href="/insights/therapeutics/central-nervous-system" data-drupal-link-system-path="node/33679">Central Nervous System</a> <div class="collapse " id="therapeutics-insights---central-nervous-system-10556" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/central-nervous-system/a-mind-for-digital-therapeutics" data-drupal-link-system-path="node/33677">A mind for digital therapeutics</a> <div class="collapse " 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