CINXE.COM
CNS Neurology | ICON plc
<!DOCTYPE html> <html lang="en" dir="ltr"> <head> <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><script type="text/javascript">piAId = '37932';piCId = '1732'; (function() { function async_load(){ var s = document.createElement('script'); s.type = 'text/javascript'; s.src = ('https:' == document.location.protocol ? 'https://pi' : 'http://cdn') + '.pardot.com/pd.js'; var c = document.getElementsByTagName('script')[0]; c.parentNode.insertBefore(s, c); } if(window.attachEvent) { window.attachEvent('onload', async_load); } else { window.addEventListener('load', async_load, false); } })();</script> <meta name="description" content="ICON has deep neurodegeneration expertise, including neuroinflammatory, neurodegenerative, neurobehavioral and pain disorders." /> <meta name="keywords" content="neurology, neurological, neurodegenerative, TBI, traumatic brain injury, Parkinson's Disease, neuroscience, alzheimers, Alzheimer's Disease, epilepsy, neuroinflammatory, neurobehavioral" /> <link rel="canonical" href="https://www.iconplc.com/therapeutics/central-nervous-system/cns-neurology" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/themes/custom/iconplc/favicon.ico" type="image/vnd.microsoft.icon" /> <script src="/sites/default/files/google_tag/gtm_container_corp/google_tag.script.js?snf4ml" defer></script> <script>window.a2a_config=window.a2a_config||{};a2a_config.callbacks=[];a2a_config.overlays=[];a2a_config.templates={};</script> <title>CNS Neurology | ICON plc</title> <link rel="stylesheet" media="all" href="/modules/contrib/ajax_loader/css/throbber-general.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/ajax-progress.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/align.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/autocomplete-loading.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/fieldgroup.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/container-inline.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/clearfix.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/details.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/hidden.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/item-list.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/js.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/nowrap.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/position-container.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/progress.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/reset-appearance.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/resize.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/sticky-header.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/system-status-counter.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/system-status-report-counters.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/system-status-report-general-info.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/tabledrag.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/tablesort.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/system/components/tree-child.module.css?snf4ml" /> <link rel="stylesheet" media="all" href="/modules/contrib/addtoany/css/addtoany.css?snf4ml" /> <link rel="stylesheet" media="all" href="/modules/contrib/ajax_loader/css/fading-circle.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/layouts/layout_discovery/onecol/onecol.css?snf4ml" /> <link rel="stylesheet" media="all" href="/modules/contrib/paragraphs/css/paragraphs.unpublished.css?snf4ml" /> <link rel="stylesheet" media="all" href="/core/themes/stable9/css/core/assets/vendor/normalize-css/normalize.css?snf4ml" /> <link rel="stylesheet" media="all" href="/themes/custom/iconplc/css/main.css?snf4ml" /> <link rel="stylesheet" media="all" href="https://maxcdn.bootstrapcdn.com/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/themes/custom/iconplc/css/theme/footer.css?snf4ml" /> <link rel="stylesheet" media="all" href="/themes/custom/iconplc/css/theme/header.css?snf4ml" /> <link rel="stylesheet" media="all" href="/libraries/slick-carousel/slick/slick.css?snf4ml" /> <script>!function(e){var n="https://s.go-mpulse.net/boomerang/";if("False"=="True")e.BOOMR_config=e.BOOMR_config||{},e.BOOMR_config.PageParams=e.BOOMR_config.PageParams||{},e.BOOMR_config.PageParams.pci=!0,n="https://s2.go-mpulse.net/boomerang/";if(window.BOOMR_API_key="6Y2MS-QG49D-DNYL6-USZAZ-APV4F",function(){function e(){if(!o){var e=document.createElement("script");e.id="boomr-scr-as",e.src=window.BOOMR.url,e.async=!0,i.parentNode.appendChild(e),o=!0}}function t(e){o=!0;var n,t,a,r,d=document,O=window;if(window.BOOMR.snippetMethod=e?"if":"i",t=function(e,n){var t=d.createElement("script");t.id=n||"boomr-if-as",t.src=window.BOOMR.url,BOOMR_lstart=(new Date).getTime(),e=e||d.body,e.appendChild(t)},!window.addEventListener&&window.attachEvent&&navigator.userAgent.match(/MSIE [67]\./))return window.BOOMR.snippetMethod="s",void t(i.parentNode,"boomr-async");a=document.createElement("IFRAME"),a.src="about:blank",a.title="",a.role="presentation",a.loading="eager",r=(a.frameElement||a).style,r.width=0,r.height=0,r.border=0,r.display="none",i.parentNode.appendChild(a);try{O=a.contentWindow,d=O.document.open()}catch(_){n=document.domain,a.src="javascript:var d=document.open();d.domain='"+n+"';void(0);",O=a.contentWindow,d=O.document.open()}if(n)d._boomrl=function(){this.domain=n,t()},d.write("<bo"+"dy onload='document._boomrl();'>");else if(O._boomrl=function(){t()},O.addEventListener)O.addEventListener("load",O._boomrl,!1);else if(O.attachEvent)O.attachEvent("onload",O._boomrl);d.close()}function a(e){window.BOOMR_onload=e&&e.timeStamp||(new Date).getTime()}if(!window.BOOMR||!window.BOOMR.version&&!window.BOOMR.snippetExecuted){window.BOOMR=window.BOOMR||{},window.BOOMR.snippetStart=(new Date).getTime(),window.BOOMR.snippetExecuted=!0,window.BOOMR.snippetVersion=12,window.BOOMR.url=n+"6Y2MS-QG49D-DNYL6-USZAZ-APV4F";var i=document.currentScript||document.getElementsByTagName("script")[0],o=!1,r=document.createElement("link");if(r.relList&&"function"==typeof r.relList.supports&&r.relList.supports("preload")&&"as"in r)window.BOOMR.snippetMethod="p",r.href=window.BOOMR.url,r.rel="preload",r.as="script",r.addEventListener("load",e),r.addEventListener("error",function(){t(!0)}),setTimeout(function(){if(!o)t(!0)},3e3),BOOMR_lstart=(new Date).getTime(),i.parentNode.appendChild(r);else t(!1);if(window.addEventListener)window.addEventListener("load",a,!1);else if(window.attachEvent)window.attachEvent("onload",a)}}(),"".length>0)if(e&&"performance"in e&&e.performance&&"function"==typeof e.performance.setResourceTimingBufferSize)e.performance.setResourceTimingBufferSize();!function(){if(BOOMR=e.BOOMR||{},BOOMR.plugins=BOOMR.plugins||{},!BOOMR.plugins.AK){var n=""=="true"?1:0,t="",a="bdpnbevydn5uqz2cz2qa-f-8af033f69-clientnsv4-s.akamaihd.net",i="false"=="true"?2:1,o={"ak.v":"39","ak.cp":"1488202","ak.ai":parseInt("949150",10),"ak.ol":"0","ak.cr":1,"ak.ipv":4,"ak.proto":"http/1.1","ak.rid":"98ab1c8","ak.r":41571,"ak.a2":n,"ak.m":"b","ak.n":"ff","ak.bpcip":"8.222.208.0","ak.cport":58692,"ak.gh":"184.27.123.29","ak.quicv":"","ak.tlsv":"tls1.2","ak.0rtt":"","ak.0rtt.ed":"","ak.csrc":"-","ak.acc":"reno","ak.t":"1732431520","ak.ak":"hOBiQwZUYzCg5VSAfCLimQ==MpdD997q9EpS5nH1R4IJZHv5a7PnosC/IkWfo+9zUVN8TCnrXdC7k1ZcaqJTk3WQQkWxvgggAYP1k8htCGRfO2qhvkxpiU9RdcapF047dHdAfImqgUhDQGvSggf8otb6GLtWm24aCy2KDLU8J52S3SjizZGLDpEZSk6Gae2wdE4KDNpb4Mq2M3LKrH3OwY8479dXiXxCflo1tasPt4CLOK3uzWNavQ/jJ9Tt7h+KcHU6IOap9Hd2xFQfexxOQ/q2pzowFDPxiHrnZ0LveqWes6TJPp1z8ciiq5admvi3BtOwI6tEfsSTLyudk9gijEngIOUKRLe2gkv+LuO6omBSUfaBO5eYsBdkZ0bBugQddX1HJPUG0rOFvyQLwgr2ys8ZHUVHwAxEqJ5HBTttQG1N9Qlt7OTP9chgI0vFBtHraeM=","ak.pv":"16","ak.dpoabenc":"","ak.tf":i};if(""!==t)o["ak.ruds"]=t;var r={i:!1,av:function(n){var t="http.initiator";if(n&&(!n[t]||"spa_hard"===n[t]))o["ak.feo"]=void 0!==e.aFeoApplied?1:0,BOOMR.addVar(o)},rv:function(){var e=["ak.bpcip","ak.cport","ak.cr","ak.csrc","ak.gh","ak.ipv","ak.m","ak.n","ak.ol","ak.proto","ak.quicv","ak.tlsv","ak.0rtt","ak.0rtt.ed","ak.r","ak.acc","ak.t","ak.tf"];BOOMR.removeVar(e)}};BOOMR.plugins.AK={akVars:o,akDNSPreFetchDomain:a,init:function(){if(!r.i){var e=BOOMR.subscribe;e("before_beacon",r.av,null,null),e("onbeacon",r.rv,null,null),r.i=!0}return this},is_complete:function(){return!0}}}}()}(window);</script></head> <body class="path-node page-node-type-standard-page"> <a href="#main-content" class="focusable skip-link"> Skip to main content </a> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-K6FFJM" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="share-buttons share-buttons--right d-none d-md-block"> <div class="region region-social-media-share"> <div id="block-addtoanysharebuttons"> <span class="a2a_kit a2a_kit_size_19 addtoany_list" data-a2a-url="https://www.iconplc.com/therapeutics/central-nervous-system/cns-neurology" data-a2a-title="CNS Neurology"><a class="a2a_button_facebook facebook"><img src="/themes/custom/iconplc/src/assets/images/social-icons/facebook-f.svg" border="0" alt="Facebook" width="19" height="19"></a><a class="a2a_button_x twitter-x"><img src="/themes/custom/iconplc/src/assets/images/social-icons/x-twitter.svg" border="0" alt="Facebook" width="19" height="19"></a><a class="a2a_button_linkedin linkedin"><img src="/themes/custom/iconplc/src/assets/images/social-icons/linkedin-in.svg" border="0" alt="Facebook" width="19" height="19"></a></span> </div> </div> </div> <div class="layout-container"> <header role="banner"> <nav class="navbar bg-white fixed-top navbar-expand-xl" role="navigation"> <div id="block-sitebranding"> <a href="/" rel="home" class="navbar-brand"> <img src="/themes/custom/iconplc/logo.svg" alt="Home" title="Home" /> </a> </div> <button type="button" class="navbar-btn navbar-btn--search" data-toggle="modal" data-target="#search-modal"> <i class="icon-ui-search-loupe" aria-hidden="true"></i> </button> <button class="navbar-btn navbar-btn--open" type="button" data-toggle="collapse" aria-controls="site-navigation" aria-expanded="false" aria-label="Toggle navigation"> <span class="sr-only">Toggle navigation</span> <span class="navbar-btn__icon"></span> </button> <div class="collapse navbar-collapse" id="site-navigation"> <div class="navbar-navs"> <button class="navbar-btn navbar-btn--close" type="button" aria-controls="site-navigation" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-btn__icon"></span> </button> <ul data-region="primary_menu" region="primary_menu" class="navbar-nav navbar-nav-primary mr-auto"> <li class="nav-item dropdown"> <a href="/solutions" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> Solutions <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><span class="h4">Clinical solutions</span></div> </div> <a class="dropdown-item" href="/solutions/blended-solutions">Blended Solutions</a> <a class="dropdown-item" href="/solutions/cardiac-safety-solutions">Cardiac Safety Solutions</a> <a class="dropdown-item" href="/solutions/clinical-scientific-operations">Clinical & Scientific Operations</a> <a class="dropdown-item" href="/solutions/decentralised-clinical-trials">Decentralised Clinical Trials</a> <a class="dropdown-item" href="/solutions/early-clinical">Early Clinical</a> <a class="dropdown-item" href="/solutions/laboratories">Laboratories</a> <a class="dropdown-item" href="/solutions/medical-imaging">Medical Imaging</a> <a class="dropdown-item" href="/solutions/site-and-patient-solutions">Site & Patient Solutions</a> <a class="dropdown-item" href="/solutions/strategic-solutions">Strategic Solutions</a> </div> <div class="col-xl-3"> <div class="mega-menu-title"> <div><span>Consulting & Commercial</span></div> </div> <a href="/solutions/consulting/asset-development" class="dropdown-item" data-drupal-link-system-path="node/33869">Asset Development Consulting</a> <a href="/solutions/consulting/commercial-positioning-consulting" class="dropdown-item" data-drupal-link-system-path="node/33875">Commercial Positioning</a> <a href="/solutions/language-services" class="dropdown-item" data-drupal-link-system-path="node/33968">Language Services</a> <a href="/solutions/real-world-intelligence" class="dropdown-item" data-drupal-link-system-path="node/33972">Real World Intelligence</a> <a href="/solutions/consulting/regulatory-affairs" class="dropdown-item" data-drupal-link-system-path="node/33892">Regulatory Affairs</a> <a href="/solutions/real-world-intelligence/symphony-health" class="dropdown-item" data-drupal-link-system-path="node/34056">Symphony Health data</a> </div> <div class="col-xl-3"> <a href="/solutions/outcome-measures" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/9899e456-4ca8-42f9-bc3e-09c8de4f19f8/web/Outcome_measures_MDD.jpg?crop=yes&w=260&h=136&itok=_baP6hiH" width="260" height="136" alt="Mega navigation image for ICON website MDD" loading="eager" title="Mega navigation image for ICON website MDD" /> </div> </div> </div> <span class="h4">Outcome Measures</span> <p class="section-overview--desktop">COAs and DHTs – measure what matters</p> </a> </div> <div class="col-xl-3"> <a href="/solutions/technologies" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/86d7484b-45a2-4ec0-8b3e-35e744ac1acf/web/Technologies-homepage%20banner.jpg?crop=yes&w=260&h=136&itok=kSzFMCbw" width="260" height="136" alt="Technologies-homepage banner.jpg" loading="eager" title="Technologies-homepage banner.jpg" /> </div> </div> </div> <span class="h4">Technologies</span> <p class="section-overview--desktop">Technology solutions from early phase through to post-marketing.</p> </a> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a href="/sectors" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> Sectors <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><span class="h4">Sectors</span></div> <div class="section-overview--desktop"> <p>ICON provides its full range of clinical, consulting and commercial services across several industry sectors.</p> </div> <a class="dropdown-item section-overview--desktop" href="/sectors">Read more</a> </div> </div> <div class="col-xl-3"> <div class="mega-menu-title"> </div> <a href="/sectors/biotech" class="dropdown-item" data-drupal-link-system-path="node/33810">Biotech</a> <a href="/sectors/government-and-public-health" class="dropdown-item" data-drupal-link-system-path="node/33814">Government and Public Health</a> <a href="/sectors/medical-device" class="dropdown-item" data-drupal-link-system-path="node/33821">Medical Device</a> <a href="/sectors/pharma" class="dropdown-item" data-drupal-link-system-path="node/33827">Pharmaceuticals</a> </div> <div class="col-xl-3"> <a href="/sectors/biotech" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/9a875746-3c1e-42ad-bf90-bf10c0eb31ec/web/ICON%20Biotech%20website%20mega%20nav.png?crop=yes&w=260&h=136&itok=p81asfWQ" width="260" height="136" alt="ICON Biotech website mega nav.png" loading="eager" title="ICON Biotech website mega nav.png" /> </div> </div> </div> <span class="h4">Biotech</span> <p class="section-overview--desktop">Developing transformative therapies requires a flexible approach.</p> </a> </div> <div class="col-xl-3"> <a href="/sectors/pharmaceuticals/partnerships" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/2e13edb4-013d-4553-aaa0-3704fe8e7939/web/icon-and-you-mdd.jpg?crop=yes&w=260&h=136&itok=GmvVWBwu" width="260" height="136" alt="icon-and-you-mdd.jpg" loading="eager" title="icon-and-you-mdd.jpg" /> </div> </div> </div> <span class="h4">ICON and You</span> <p class="section-overview--desktop">Partners making a difference.</p> </a> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a href="/therapeutics" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> Therapeutics <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><a href="/therapeutics" target="_self">Therapeutics</a></div> </div> <a class="dropdown-item" href="/therapeutics/cardiovascular">Cardiovascular</a> <a class="dropdown-item" href="/therapeutics/central-nervous-system">Central Nervous System</a> <a class="dropdown-item" href="/therapeutics/endocrine-metabolic-disorders">Endocrine & Metabolic Disorders</a> <a class="dropdown-item" href="/therapeutics/infectious-diseases">Infectious Diseases</a> <a class="dropdown-item" href="/therapeutics/internal-medicine-immunology">Internal Medicine & Immunology</a> <a class="dropdown-item" href="/therapeutics/oncology">Oncology</a> </div> <div class="col-xl-3"> <div class="mega-menu-title"> <div><span>Cross-therapeutics</span></div> </div> <a href="/therapeutics/biosimilars" class="dropdown-item" data-drupal-link-system-path="node/33807">Biosimilars</a> <a href="/therapeutics/cell-and-gene-therapies" class="dropdown-item" data-drupal-link-system-path="node/34067">Cell and Gene Therapies</a> <a href="/therapeutics/medical-device" class="dropdown-item" data-drupal-link-system-path="node/34085">Medical Device</a> <a href="/therapeutics/pediatrics" class="dropdown-item" data-drupal-link-system-path="node/34089">Pediatrics</a> <a href="/therapeutics/rare-orphan-diseases" class="dropdown-item" data-drupal-link-system-path="node/34090">Rare & Orphan Diseases</a> <a href="/therapeutics/vaccines" class="dropdown-item" data-drupal-link-system-path="node/34092">Vaccines</a> <a href="/therapeutics/womens-health" class="dropdown-item" data-drupal-link-system-path="node/34094">Women's Health</a> </div> <div class="col-xl-3"> <a href="/therapeutics/endocrine-metabolic-disorders/obesity" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/9ddd8e65-786a-4ddd-a3f8-56a75fba4ab3/web/Obesity_MDD.jpg?crop=yes&w=260&h=136&itok=3FHb2-iA" width="260" height="136" alt="Obesity_MDD.jpg" loading="eager" title="Obesity_MDD.jpg" /> </div> </div> </div> <span class="h4">Obesity</span> <p class="section-overview--desktop">A focus on combination therapies requires appropriate obesity-specific trial designs, long-term follow-up studies and diverse patient recruitment.</p> </a> </div> <div class="col-xl-3"> <a href="/insights/therapeutics" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/78559377-8cc3-4bc6-b6f2-cc20a04e1504/web/cells-menu-hero.jpg?crop=yes&w=260&h=136&itok=0ESOS9pw" width="260" height="136" alt="cells-menu-hero.jpg" loading="eager" title="cells-menu-hero.jpg" /> </div> </div> </div> <span class="h4">Therapeutics insights</span> <p class="section-overview--desktop">ICON's therapeutic experts contribute regularly to industry publications and the creation of thought leadership content. Read more. </p> </a> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a href="/insights" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> Insights <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><a href="/insights" target="_self">Insights</a></div> </div> <a class="dropdown-item" href="/insights/digital-disruption">Digital Disruption</a> <a class="dropdown-item" href="/insights/patient-centricity">Patient Centricity</a> <a class="dropdown-item" href="/insights/regulatory-intelligence">Regulatory Intelligence</a> <a class="dropdown-item" href="/insights/therapeutics">Therapeutics insights</a> <a class="dropdown-item" href="/insights/transforming-trials">Transforming Trials</a> <a class="dropdown-item" href="/insights/value-based-healthcare">Value Based Healthcare</a> <a class="dropdown-item" href="/insights/blog">Blog</a> <a class="dropdown-item" href="/insights/videos">Videos</a> <a class="dropdown-item" href="https://webinars.iconplc.com">Webinar Channel</a> </div> <div class="col-xl-3"> <a href="/insights/transforming-trials/blended-solutions-insights/embracing-blended-operating-model" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/f7dc31ec-43dc-49b9-aa7b-939e5572e257/web/Blended%20solutions_MDD.jpg?crop=yes&w=260&h=136&itok=yv16XaJb" width="260" height="136" alt="blended solutions" loading="eager" title="blended solutions" /> </div> </div> </div> <span class="h4">Embracing a blended operating model</span> <p class="section-overview--desktop">Maximising efficiency and flexibility with custom outsourcing</p> </a> </div> <div class="col-xl-3"> <a href="/insights/therapeutics-insights/oncology/de-risking-clinical-development-precision-medicines" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/a2f99da8-e333-4f57-8700-d1d3f72f301e/web/MDD_OncologyWhitepaper.jpg?crop=yes&w=260&h=136&itok=4Jnst3Tp" width="260" height="136" alt="Oncology whitepaper web assets" loading="eager" title="Oncology whitepaper web assets" /> </div> </div> </div> <span class="h4">De-risking clinical development of precision medicines in oncology</span> <p class="section-overview--desktop">An evolving understanding of cancer biology has resulted in the rise of precision-informed treatment approaches.</p> </a> </div> <div class="col-xl-3"> <a href="/insights/value-based-healthcare/strategies-commercialising-oncology-treatments-young-adults" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/fa37bc49-7fc2-43b7-a5a7-22213c7da3b2/web/Oncology-youngadults_thumbnail_whitepaper.jpg?crop=yes&w=260&h=136&itok=zl9MWidU" width="260" height="136" alt="Oncology-youngadults_thumbnail_whitepaper.jpg" loading="eager" title="Oncology-youngadults_thumbnail_whitepaper.jpg" /> </div> </div> </div> <span class="h4">Strategies for commercialising oncology treatments for young adults</span> <p class="section-overview--desktop">Oncology treatments tailored specifically for young adults.</p> </a> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a href="/news-events" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> News & Events <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><span class="h4">News & Events</span></div> <div class="section-overview--desktop"> <p>ICON regularly contributes thought leadership to industry media publications and conferences, and has been recognised as one of the world’s leading Contract Research Organisations through a number of high-profile industry awards.</p> </div> <a class="dropdown-item section-overview--desktop" href="/news-events">Read more</a> </div> </div> <div class="col-xl-3"> <div class="mega-menu-title"> </div> <a href="/news-events/press-releases" class="dropdown-item" data-drupal-link-system-path="node/33789">Press releases</a> <a href="/news-events/thought-leadership" class="dropdown-item" data-drupal-link-system-path="node/34266">In the News</a> <a href="/news-events/mediakit" class="dropdown-item" data-drupal-link-system-path="node/33787">Mediakit</a> <a href="/news-events/awards" class="dropdown-item" data-drupal-link-system-path="node/33778">Awards</a> <a href="/news-events/events" class="dropdown-item" data-drupal-link-system-path="node/34258">Events</a> <a href="/news-events/events/webinars" class="dropdown-item" data-drupal-link-system-path="node/34260">Webinars</a> <a href="/news-events/social-media" class="dropdown-item" data-drupal-link-system-path="node/33790">Social media</a> </div> <div class="col-xl-3"> <a href="/news-events/events/webinars/s-stands-systematic-demystifying-systematic-literature-review" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/9a9accce-4155-444f-b063-33f4e93a91ed/web/digital_data_computer_MDD_300x157px.jpg?crop=yes&w=260&h=136&itok=SYn4y_Yf" width="260" height="136" alt="digital_data_computer" loading="eager" title="digital_data_computer" /> </div> </div> </div> <span class="h4">“S” stands for systematic: Demystifying the systematic literature review</span> <p class="section-overview--desktop">5 December 2024</p> </a> </div> <div class="col-xl-3"> <a href="https://webinars.iconplc.com/detail/videos/clinical-research-services_/video/6363975248112/dosimetry-in-clinical-trials?autoStart=true" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/a2adec58-c2b5-4085-9b7f-09b42493f545/web/MDD_300x157.jpg?crop=yes&w=260&h=136&itok=PtYs9Hjy" width="260" height="136" alt="dosimetry thumbnail" loading="eager" title="dosimetry thumbnail" /> </div> </div> </div> <span class="h4">Dosimetry in clinical trials</span> <p class="section-overview--desktop">Watch the recording</p> </a> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a href="/about" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> About ICON <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><a href="/about" target="_self">About ICON</a></div> </div> <a class="dropdown-item" href="/about/company-history">Company history</a> <a class="dropdown-item" href="/about/healthcare-intelligence">Healthcare Intelligence</a> <a class="dropdown-item" href="/about/icon-in-asia-pacific">ICON in Asia Pacific</a> <a class="dropdown-item" href="/about/icon-in-latin-america">ICON in Latin America</a> <a class="dropdown-item" href="/about/leadership">Leadership</a> <a class="dropdown-item" href="/about/quality">Quality</a> </div> <div class="col-xl-3"> <div class="mega-menu-title"> <div><span>ICON for</span></div> </div> <a href="https://www.accellacare.com/" target="_blank" class="dropdown-item">Patients</a> <a href="https://iconstudies.com/" target="_blank" class="dropdown-item">Volunteers</a> <a href="/investigators" class="dropdown-item" data-drupal-link-system-path="node/33762">Investigators</a> <a href="https://careers.iconplc.com/" target="_blank" class="dropdown-item">Jobs & Careers</a> <a href="https://investor.iconplc.com/" target="_blank" class="dropdown-item">Investors</a> <a href="/about-icon/environmental-social-and-governance/governance/icon-suppliers" class="dropdown-item" data-drupal-link-system-path="node/33804">Suppliers</a> </div> <div class="col-xl-3"> <a href="/about/esg/" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/218ee692-1b56-4781-81ac-a5c21d998441/web/esg-mdd.jpg?crop=yes&w=260&h=136&itok=4lb_pyzu" width="260" height="136" alt="esg-mdd.jpg" loading="eager" title="esg-mdd.jpg" /> </div> </div> </div> <span class="h4">Sustainability, diversity and charity</span> <p class="section-overview--desktop">ICON Cares is our commitment to making a positive impact on our people, environment and our community.</p> </a> </div> <div class="col-xl-3"> <a href="/about/clinical-research-evolved/" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/731c8b9b-5eec-4227-903e-e4e1b9baf5a7/web/healthcare-intelligence-video-poster.png?crop=yes&w=260&h=136&itok=7ocDsNRo" width="260" height="136" alt="healthcare-intelligence-video-poster.png" loading="eager" title="healthcare-intelligence-video-poster.png" /> </div> </div> </div> <span class="h4">Healthcare Intelligence</span> <p class="section-overview--desktop">Clinical Research. Evolved.</p> </a> </div> </div> </div> </div> </li> </ul> <ul region="primary_menu" class="navbar-nav navbar-nav-secondary"> <li class="nav-item"> <a href="https://careers.iconplc.com/" class="nav-link" target="_blank">Careers</a> </li> <li class="nav-item"> <a href="http://investor.iconplc.com/" class="nav-item-separator nav-link" target="_blank">Investors</a> </li> <li class="nav-item"> <a href="/contact" class="nav-item-separator nav-link" target="_self" data-drupal-link-system-path="node/33596">Contact</a> </li> <li class="nav-item"> <a href="https://iconplc.co.jp/" class="nav-link" target="_blank">日本語</a> </li> <li class="nav-item"> <a href="https://china.iconplc.com/" class="nav-link nav-item-separator" target="_blank">简体中文</a> </li> <li class="nav-item d-none d-xl-block"> <a class="nav-link" data-toggle="modal" href="#search-modal"> <i aria-hidden="true" class="icon-ui-search-loupe"></i> </a> </li> </ul> </div> <div class="navbar-revealer"></div> </div> <div class="navigation-backdrop fade"></div> </nav> </header> <div class="region region-highlighted"> <div data-drupal-messages-fallback class="hidden"></div> </div> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <div class="region region-content"> <div id="block-iconplc-content"> <article> <div> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div id="d81c9ab8-25a4-4098-bbce-709139e8206d" class="promo--wrapper"> <div class="breadcrumb-wrapper "> <ol class="breadcrumb"> <li class="breadcrumb-item"> <a href="/" class="breadcrumb__link">Home</a> </li> <li class="breadcrumb-item"> <a href="/therapeutics" class="breadcrumb__link">Therapeutics</a> </li> <li class="breadcrumb-item"> <a href="/therapeutics/central-nervous-system" class="breadcrumb__link">Central Nervous System</a> </li> <li class="breadcrumb-item"> CNS Neurology </li> </ol> </div> <div> <div class="promo promo--subpage" data-title="CNS Neurology"> <div class="promo__content"> <div class="promo__image-overlay promo__image-overlay--green-dark"></div> <div title="CNS" data-responsive-backgrounds="true" data-responsive-background-lg="https://icon.widen.net/content/a1aa18ce-2129-4883-a4b9-dcbe5d0af0c7/web/11084-Neurodegenerative-Diseases_subpage-(2).jpg?crop=yes&w=1920&h=507&a=0,11&itok=Ba89ik5B" data-responsive-background-md="https://icon.widen.net/content/a1aa18ce-2129-4883-a4b9-dcbe5d0af0c7/web/11084-Neurodegenerative-Diseases_subpage-(2).jpg?crop=yes&w=1895&h=600&a=25,0&itok=LAQDV7Aj" data-responsive-background-sm="https://icon.widen.net/content/a1aa18ce-2129-4883-a4b9-dcbe5d0af0c7/web/11084-Neurodegenerative-Diseases_subpage-(2).jpg?crop=yes&w=1566&h=600&a=354,0&itok=c6pV1DuF" data-responsive-background-xs="https://icon.widen.net/content/a1aa18ce-2129-4883-a4b9-dcbe5d0af0c7/web/11084-Neurodegenerative-Diseases_subpage-(2).jpg?crop=yes&w=402&h=600&a=1294,0&itok=iFB92lbe" class="promo__image-container"></div> <div class="promo__text-container"> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-md-9"> <h1>CNS Neurology</h1> <p class="lead">Deep neurodegeneration expertise and innovative technology solutions</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid container-fluid--xl"> <div class="row no-gutters"> <div class="col-md-9 order-2"> <section class="main-content"> <div class="content-box sidebar-content"> <div id="d73039af-e5c1-40a5-9233-e17fc0bb205e"> <div class="lead-text text-left bg-white"> <div class="container-fluid container-fluid--xl"> <h2> The prevalence and incidence of neurodegenerative diseases is projected to rise, however, there are currently no treatments to slow neurodegeneration for most diseases. </h2> </div> </div> </div> <div id="63847107-2e61-4344-8020-53062fd0721e"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> </h3> <div> <p><strong>While there is a critical need to advance research, clinical trials in this field are complex and patient recruitment and retention are often a challenge.</strong></p> <p>Reducing patient burden is especially important in neurodegenerative studies. Our solutions make it convenient for the patient to complete the protocol assessments and stay engaged throughout the clinical study.</p> <p>ICON <a href="/solutions/decentralised-clinical-trials/In-home-clinical-services/" target="_self">In-Home and Alternate Site Clinical Solutions</a> plus the use of telemedicine technology and <a href="/solutions/technologies/firecrest" target="_self">FIRECREST</a> eViewer and eConsent, allow for a most patient-friendly study set-up – in the past five years, ICON's Symphony Clinical Research has supported 57 studies in neurology with in-home clinical trial services</p> <p><a href="https://www.accellacare.com/" target="_blank">Accellacare</a>, <a href="/solutions/site-and-patient-solutions/clinical-site-solutions/" target="_self">ICON's Global Site Network</a> includes 55 CNS specialised sites across the globe with a proven track record in studies in neurodegeneration for rapid start-up, competent execution and patient access. We use these sites to evaluate the site and patient burden of a protocol prior to it being finalised.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="50c7d54b-2f12-452b-b93c-deb3262604c8" class="icon-group icon-group--horizontal"> <div class="container-fluid container-fluid--xl"> <h2 class="icon-group__title">ICON neurodegenerative and neuromuscular experience in last five years</h2> <ul class="icon-group__items icon-group__items__columns-3"> <li class="icon-group__item--blue"> <div lang="en" class="icon-group__wrapper" > <i class="icon-content-development"></i> <p class="mb-2 icons-large-text">167</p> <small>Neurodegenerative and neuromuscular clinical studies</small> </div> </li> <li class="icon-group__item--green-bright"> <div lang="en" class="icon-group__wrapper" > <i class="icon-patient"></i> <p class="mb-2 icons-large-text">18,650+</p> <small>neurodegenerative and neuromuscular patients and healthy volunteers (HV)</small> </div> </li> <li class="icon-group__item--blue-light"> <div lang="en" class="icon-group__wrapper" > <i class="icon-global"></i> <p class="mb-2 icons-large-text">4,200+</p> <small>sites globally</small> </div> </li> </ul> </div> </div> <div id="16d0f068-0416-4e65-8af4-1a925dda7c7a"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/factsheet_neurodegenerative_diseases" target="_blank" title="Brochure: Neurodegenerative diseases"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/5499b91a-f652-4f7b-83c5-7fd88e18028c/web/11084-Neurodegenerative-Diseases-Factsheet_Thumbnail.jpg?h=240&itok=kDEfxYvp" width="170" height="240" alt="11084-Neurodegenerative-Diseases-Factsheet_Thumbnail.jpg" loading="lazy" title="11084-Neurodegenerative-Diseases-Factsheet_Thumbnail.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Brochure: Neurodegenerative diseases</h3> <p>Our broad expertise in neurodegeneration encompasses multiple indications, including: Adrenoleukodystrophy, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Diabetic Peripheral Neuropathy, Familial Amyloid Polyneuropathy, Huntington’s Disease, Metachromatic Leukodystrophy, Multiple Sclerosis, Multiple System Atrophy, Parkinson’s Disease, Progressive Supranuclear Palsy, Spasticity</p> </span> </a> </div> </div> </div> </div> <div id="d874d205-f065-4a63-9803-ec048e8dc9f9"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/Factsheet_ICONIK_RSA" target="_blank" title="ICONIK Rating Scale Analytics"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/b352667f-c1df-4614-84a6-32908985df8e/web/Factsheet-ICONIK-RSA.jpg?h=240&itok=WCdZXkF8" width="170" height="240" alt="Factsheet-ICONIK-RSA.jpg" loading="lazy" title="Factsheet-ICONIK-RSA.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>ICONIK Rating Scale Analytics</h3> <p>ICONIK Rating Scale and eCOA Analytics Solution (RSA) is an advanced suite of data visualisation and analytics tools developed to drive quality, consistency and objectivity in rating scales and patient reported or patient centric data.</p> </span> </a> </div> </div> </div> </div> <div id="a89b56ed-57bb-401e-9635-5edd46e879b3"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> Wet, imaging and digital biomarker neurology endpoints </h3> <div> <p>ICON has all relevant services for wet, imaging and digital biomarker endpoints in house:</p> <p>ICON <a href="/solutions/laboratories/bioanalytical-laboratories/" target="_self">Bioanalytical Laboratories</a> support the development and analysis of biomarker assays in the neurodegenerative disease space including determination of A-B 1-42, Total tau, Phospho tau, NFL, APOE Geno, and APOE.</p> <p>ICON <a href="/solutions/imaging/" target="_self">Medical Imaging</a> has supported 20+ studies in neurodegenerative indications and provides rigorous analysis of novel imaging endpoints and surrogate markers.</p> <p>ICON provides an end-to-end approach to effective <a href="/insights/digital-disruption/mHealth-wearables/" target="_self">integration of wearable devices into trial design, execution and reporting</a>. Our digital health technology team has experience developing such frameworks - from device selection to endpoint generation and operational management.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div><div id="b90ed605-e85f-4b49-820a-7ce2623d97bb"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/Case_Study_Parkinson%E2%80%99s_disease_recruitment" target="_blank" title="Overcoming recruitment challenges - Parkinson's Case Study"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/36c175c1-4fac-496a-91e4-586cf5c9fae0/web/Case%20study_Parkinsons_thumbnail.png?h=240&itok=8NhxANZW" width="170" height="240" alt="Case study_Parkinsons_thumbnail.png" loading="lazy" title="Case study_Parkinsons_thumbnail.png" /> </div> </div> </div> </span> <span class="file__details"> <h3>Overcoming recruitment challenges - Parkinson's Case Study</h3> <p>Parkinson disease (PD) is highly prevalent among neurodegenerative diseases, affecting a diverse patient population. Despite a general willingness of patients to participate in clinical trials, only a subset of patients enroll in them.</p> </span> </a> </div> </div> </div> </div> <div id="bbd240d4-9201-4b23-8b7e-b6024e8e0484"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/whitepaper_traumatic_brain_injury" target="_blank" title="Traumatic Brain Injury: From identifying biomarkers to improving clinical trial efficiency"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/733936a5-2599-49af-9c39-56d0a6b6bdac/web/Whitepaper_Traumatic_Brain_Injury_TBI_Thumbnails.jpg?h=240&itok=RK5XBBJa" width="170" height="240" alt="Whitepaper_Traumatic_Brain_Injury_TBI_Thumbnails.jpg" loading="lazy" title="Whitepaper_Traumatic_Brain_Injury_TBI_Thumbnails.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Traumatic Brain Injury: From identifying biomarkers to improving clinical trial efficiency</h3> <p>This whitepaper explores the impact of TBI on different populations as well as challenges and opportunities in clinical research.</p> </span> </a> </div> </div> </div> </div> <div id="ee20fb65-eb6d-4320-bf18-5ae5c07ee0e1"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/Infographic_Traumatic_Brain_Injury" target="_blank" title="Traumatic Brain Injury infographic"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/6460979a-a567-475b-a278-7d6f46bcae01/web/11397-TBI-Whitepaper_Infographic.jpg?h=240&itok=rDJrXZwz" width="170" height="240" alt="11397-TBI-Whitepaper_Infographic.jpg" loading="lazy" title="11397-TBI-Whitepaper_Infographic.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Traumatic Brain Injury infographic</h3> <p>This infographic is a visual summary of the above TBI whitepaper</p> </span> </a> </div> </div> </div> </div> <div id="44150154-9901-48d8-9306-35b1e2f585a5"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="/insights/therapeutics/central-nervous-system/key-considerations-for-parkinsons-disease-trials" target="_self" title="Whitepaper: Key considerations for Parkinson’s disease trials"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/0f8bfd6c-bb5f-4ad4-bf4e-060224825409/web/WP-Parkinsons_Disease.jpg?h=240&itok=_-DI9veg" width="170" height="240" alt="WP-Parkinsons_Disease.jpg" loading="lazy" title="WP-Parkinsons_Disease.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Whitepaper: Key considerations for Parkinson’s disease trials</h3> <p>Download the whitepaper</p> </span> </a> </div> </div> </div> </div> <div id="3103f8c5-b233-4afd-a6c4-4e960b674ed4"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> Cell and gene therapies for neurodegenerative diseases </h3> <div> <p>Clinical gene therapy has emerged as an innovative therapeutic strategy for a wide range of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and <a href="/therapeutics/rare-and-orphan-diseases/" target="_self">rare diseases</a> such as Huntington’s disease or Amyotrophic lateral sclerosis. ICON has a deep understanding of the specific regulatory, clinical and operational challenges of<a href="/therapeutics/cell-and-gene-therapies/" target="_self"> Cell and Gene Therapy clinical trials</a> having conducted 135 such studies, including 3 very recently in the neurodegenerative space.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="aa8ec77d-3ee3-4d8c-98fb-cb7f6b496655"> <div class="bg-gray"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h2>CNS, pain and ageing related disorders insights</h2> <h3> </h3> <div> <p>ICON's experienced neuroscience and drug development teams regularly share their insights in industry publications and through ICON produced content in the form of blogs and whitepapers. Read more content from our experts.</p> </div> <a class="btn btn-primary btn-md" href="/insights/therapeutics/central-nervous-system" target="_self">Read more </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </second> </div> <div class="col-md-3 order-1"> <div id="8090126b-2753-40c0-849a-79947e0b0848"> <div class="container-fluid container-fluid--xl sidebar-menu-wrapper"> <div class="sidebar"> <div class="sidebar sidebar--sticky sidebar--collapsible"> <a class="sidebar--collapsible__toggle collapsed" role="button" data-toggle="collapse" href="#sidebar-content" aria-expanded="false" aria-controls="sidebar-content"> <span>In this section</span> </a> <div class="sidebar--collapsible__content collapse" id="sidebar-content"> <div class="sidebar--menu"> <h6 class="d-none d-md-block">In this section</h6> <ul class="sidebar--collapsible__list"> <li> <a href="/therapeutics/biosimilars" data-drupal-link-system-path="node/33807">Biosimilars</a> <div class="collapse " id="biosimilars-10484" > </div> </li> <li> <a href="/therapeutics/cardiovascular" title="ICON has extensive experience in cardiovascular clinical research trials across the entire drug development spectrum." data-drupal-link-system-path="node/34066">Cardiovascular</a> <div class="collapse " id="cardiovascular-10511" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#cell-and-gene-therapies-10512"></span> <a href="/therapeutics/cell-and-gene-therapies" data-drupal-link-system-path="node/34067">Cell and Gene Therapies</a> <div class="collapse " id="cell-and-gene-therapies-10512" > <ul class="menu menu-level-1"> <li> <a href="/insights/value-based-healthcare/the-affordability-hurdle-for-gene-therapies" data-drupal-link-system-path="node/33755">The affordability hurdle for gene therapies</a> <div class="collapse " id="cell-and-gene-therapies-the-affordability-hurdle-for-gene-therapies-10513" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class=" " data-toggle="collapse" role="button" href="#central-nervous-system-10514"></span> <a href="/therapeutics/central-nervous-system" data-drupal-link-system-path="node/34071">Central Nervous System</a> <div class="collapse show" id="central-nervous-system-10514" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/central-nervous-system/cns-neurology" class="active is-active" data-drupal-link-system-path="node/34068">CNS Neurology</a> <div class="collapse show" id="central-nervous-system-cns-neurology-10515" > </div> </li> <li> <a href="/therapeutics/central-nervous-system/cns-pain" data-drupal-link-system-path="node/34069">CNS Pain</a> <div class="collapse " id="central-nervous-system--cns-pain-10516" > </div> </li> <li> <a href="/therapeutics/central-nervous-system/cns-psychiatry" data-drupal-link-system-path="node/34070">CNS Psychiatry</a> <div class="collapse " id="central-nervous-system---cns-psychiatry-10517" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials" data-drupal-link-system-path="node/33678">Challenges and opportunities in traumatic brain injury clinical trials</a> <div class="collapse " id="central-nervous-system----challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials-10518" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-for-parkinsons-disease-trials" data-drupal-link-system-path="node/33680">Challenges and opportunities in Parkinson’s Disease clinical trials</a> <div class="collapse " id="central-nervous-system-----challenges-and-opportunities-in-parkinson-s-disease-clinical-trials-10519" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-in-chronic-pain-clinical-trials" data-drupal-link-system-path="node/33681">Key considerations in chronic pain clinical trials</a> <div class="collapse " id="central-nervous-system------key-considerations-in-chronic-pain-clinical-trials-10520" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#endocrine-metabolic-disorders-10521"></span> <a href="/therapeutics/endocrine-metabolic-disorders" data-drupal-link-system-path="node/34072">Endocrine & Metabolic Disorders</a> <div class="collapse " id="endocrine-metabolic-disorders-10521" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/endocrine-metabolic-disorders/obesity" data-drupal-link-system-path="node/38991">Obesity</a> <div class="collapse " id="endocrine-metabolic-disorders-obesity-11021" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#endocrine-metabolic-disorders--metabolic-dysfunction-associated-steatohepatitis-mash--10522"></span> <a href="/therapeutics/endocrine-metabolic-disorders/non-alcoholic-steatohepatitis-nash" data-drupal-link-system-path="node/34073">Metabolic dysfunction-associated steatohepatitis (MASH)</a> <div class="collapse " id="endocrine-metabolic-disorders--metabolic-dysfunction-associated-steatohepatitis-mash--10522" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/nash/the-voice-of-nash-investigators-in-patient-recruitment" data-drupal-link-system-path="node/33694">The voice of NASH investigators</a> <div class="collapse " id="metabolic-dysfunction-associated-steatohepatitis-mash--the-voice-of-nash-investigators-10523" > </div> </li> </ul> </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#infectious-diseases-10524"></span> <a href="/therapeutics/infectious-diseases" data-drupal-link-system-path="node/34076">Infectious Diseases</a> <div class="collapse " id="infectious-diseases-10524" > <ul class="menu menu-level-1"> <li> <a href="/insights/therapeutics/infectious-diseases/antimicrobial-resistance" data-drupal-link-system-path="node/33685">Antimicrobial resistance</a> <div class="collapse " id="infectious-diseases-antimicrobial-resistance-10525" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/hiv" data-drupal-link-system-path="node/33689">HIV</a> <div class="collapse " id="infectious-diseases--hiv-10526" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccine-trials" data-drupal-link-system-path="node/33687">Pandemic respiratory vaccine clinical trials</a> <div class="collapse " id="infectious-diseases---pandemic-respiratory-vaccine-clinical-trials-10527" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#internal-medicine-immunology-10528"></span> <a href="/therapeutics/internal-medicine-immunology" data-drupal-link-system-path="node/34080">Internal Medicine & Immunology</a> <div class="collapse " id="internal-medicine-immunology-10528" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/internal-medicine-and-immunology/dermatology" data-drupal-link-system-path="node/34077">Dermatology</a> <div class="collapse " id="internal-medicine-immunology-dermatology-10529" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#internal-medicine-immunology--gastrointestinal-10530"></span> <a href="/therapeutics/internal-medicine-immunology/gastrointestinal" data-drupal-link-system-path="node/34078">Gastrointestinal</a> <div class="collapse " id="internal-medicine-immunology--gastrointestinal-10530" > <ul class="menu menu-level-2"> <li> <a href="/therapeutics/internal-medicine-and-immunology/gastrointestinal/inflammatory-bowel-disease" data-drupal-link-system-path="node/34079">Inflammatory Bowel Disease</a> <div class="collapse " id="gastrointestinal-inflammatory-bowel-disease-10531" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/ophthalmology" data-drupal-link-system-path="node/34081">Ophthalmology</a> <div class="collapse " id="internal-medicine-immunology---ophthalmology-10532" > </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/respiratory" data-drupal-link-system-path="node/34082">Respiratory</a> <div class="collapse " id="internal-medicine-immunology----respiratory-10533" > </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/rheumatology" data-drupal-link-system-path="node/34083">Rheumatology</a> <div class="collapse " id="internal-medicine-immunology-----rheumatology-10534" > </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/transplant-immunology" data-drupal-link-system-path="node/34091">Transplant Immunology</a> <div class="collapse " id="internal-medicine-immunology------transplant-immunology-10544" > </div> </li> <li> <a href="/therapeutics/internal-medicine-and-immunology/urology" data-drupal-link-system-path="node/34084">Urology</a> <div class="collapse " id="internal-medicine-immunology-------urology-10535" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/medical-device" data-drupal-link-system-path="node/34085">Medical Device</a> <div class="collapse " id="medical-device-10536" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#oncology-10537"></span> <a href="/therapeutics/oncology" data-drupal-link-system-path="node/34088">Oncology</a> <div class="collapse " id="oncology-10537" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/oncology/early-phase-oncology" data-drupal-link-system-path="node/34086">Early Phase Oncology</a> <div class="collapse " id="oncology-early-phase-oncology-10538" > </div> </li> <li> <a href="/therapeutics/oncology/immuno-oncology" data-drupal-link-system-path="node/34087">Immuno-Oncology</a> <div class="collapse " id="oncology--immuno-oncology-10539" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/pediatrics" data-drupal-link-system-path="node/34089">Pediatrics</a> <div class="collapse " id="pediatrics-10540" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#rare-orphan-diseases-10541"></span> <a href="/therapeutics/rare-orphan-diseases" data-drupal-link-system-path="node/34090">Rare & Orphan Diseases</a> <div class="collapse " id="rare-orphan-diseases-10541" > <ul class="menu menu-level-1"> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/leveraging-historical-data-for-use-in-rare-disease-trials" data-drupal-link-system-path="node/33707">Leveraging historical data for use in rare disease trials</a> <div class="collapse " id="rare-orphan-diseases-leveraging-historical-data-for-use-in-rare-disease-trials-10542" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/patient-centricity-in-orphan-drug-development" data-drupal-link-system-path="node/33709">Patient centricity in orphan drug development</a> <div class="collapse " id="rare-orphan-diseases--patient-centricity-in-orphan-drug-development-10543" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#vaccines-10546"></span> <a href="/therapeutics/vaccines" data-drupal-link-system-path="node/34092">Vaccines</a> <div class="collapse " id="vaccines-10546" > <ul class="menu menu-level-1"> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccine-trials" data-drupal-link-system-path="node/33687">Pandemic respiratory vaccine clinical trials</a> <div class="collapse " id="vaccines-pandemic-respiratory-vaccine-clinical-trials-10547" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/womens-health" data-drupal-link-system-path="node/34094">Women's Health</a> <div class="collapse " id="women-s-health-10545" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-10548"></span> <a href="/insights/therapeutics" data-drupal-link-system-path="node/33684">Therapeutics insights</a> <div class="collapse " id="therapeutics-insights-10548" > <ul class="menu menu-level-1"> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-cardiovascular-10549"></span> <a href="/insights/therapeutics/cardiovascular" data-drupal-link-system-path="node/33670">Cardiovascular</a> <div class="collapse " id="therapeutics-insights-cardiovascular-10549" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/cardiovascular/mitigating-the-impact-of-covid19-on-cardiovascular-trials" data-drupal-link-system-path="node/33671">Mitigating the impact of COVID-19 on cardiovascular trials</a> <div class="collapse " id="cardiovascular-mitigating-the-impact-of-covid-19-on-cardiovascular-trials-10550" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights--cell-and-gene-therapies-10551"></span> <a href="/insights/therapeutics/cell-and-gene-therapies" data-drupal-link-system-path="node/33674">Cell and Gene Therapies</a> <div class="collapse " id="therapeutics-insights--cell-and-gene-therapies-10551" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/approaching-the-car-t-cell-therapy-horizon" data-drupal-link-system-path="node/33672">Approaching the CAR T-cell therapy horizon</a> <div class="collapse " id="cell-and-gene-therapies-approaching-the-car-t-cell-therapy-horizon-10552" > </div> </li> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/cell-and-gene-therapy-clinical-trials" data-drupal-link-system-path="node/33673">Cell and Gene ebook</a> <div class="collapse " id="cell-and-gene-therapies--cell-and-gene-ebook-10553" > </div> </li> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/long-term-follow-up-studies-of-cell-and-gene-therapies" data-drupal-link-system-path="node/33675">Long-term follow-up studies of cell and gene therapies</a> <div class="collapse " id="cell-and-gene-therapies---long-term-follow-up-studies-of-cell-and-gene-therapies-10554" > </div> </li> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/mainstreaming-cell-gene-therapies" data-drupal-link-system-path="node/33676">Mainstreaming Cell & Gene Therapies</a> <div class="collapse " id="cell-and-gene-therapies----mainstreaming-cell-gene-therapies-10555" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights---central-nervous-system-10556"></span> <a href="/insights/therapeutics/central-nervous-system" data-drupal-link-system-path="node/33679">Central Nervous System</a> <div class="collapse " id="therapeutics-insights---central-nervous-system-10556" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/central-nervous-system/a-mind-for-digital-therapeutics" data-drupal-link-system-path="node/33677">A mind for digital therapeutics</a> <div class="collapse " id="central-nervous-system-a-mind-for-digital-therapeutics-10557" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials" data-drupal-link-system-path="node/33678">Challenges and opportunities in traumatic brain injury clinical trials</a> <div class="collapse " id="central-nervous-system--challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials-10558" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-for-parkinsons-disease-trials" data-drupal-link-system-path="node/33680">Challenges and opportunities in Parkinson’s Disease clinical trials</a> <div class="collapse " id="central-nervous-system---challenges-and-opportunities-in-parkinson-s-disease-clinical-trials-10559" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-in-chronic-pain-clinical-trials" data-drupal-link-system-path="node/33681">Key Considerations in Chronic Pain Clinical Trials</a> <div class="collapse " id="central-nervous-system----key-considerations-in-chronic-pain-clinical-trials-10560" > </div> </li> </ul> </div> </li> <li> <a href="/insights/therapeutics/glycomics" data-drupal-link-system-path="node/33683">Glycomics</a> <div class="collapse " id="therapeutics-insights----glycomics-10562" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-----infectious-diseases-10563"></span> <a href="/insights/therapeutics/infectious-diseases" data-drupal-link-system-path="node/33690">Infectious Diseases</a> <div class="collapse " id="therapeutics-insights-----infectious-diseases-10563" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/infectious-diseases/antimicrobial-resistance" data-drupal-link-system-path="node/33685">Antimicrobial Resistance</a> <div class="collapse " id="infectious-diseases-antimicrobial-resistance-10564" > </div> </li> <li> <a href="/therapeutics/therapeutics-insights/infectious-diseases/considerations-strengthening-vaccine" data-drupal-link-system-path="node/33686">Considerations for strengthening vaccine development</a> <div class="collapse " id="infectious-diseases--considerations-for-strengthening-vaccine-development-10565" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccine-trials" data-drupal-link-system-path="node/33687">COVID-19 vaccine trials</a> <div class="collapse " id="infectious-diseases---covid-19-vaccine-trials-10566" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccines-pass" data-drupal-link-system-path="node/33688">COVID-19 vaccines: Post-authorisation safety surveillance</a> <div class="collapse " id="infectious-diseases----covid-19-vaccines-post-authorisation-safety-surveillance-10567" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/hiv" data-drupal-link-system-path="node/33689">HIV</a> <div class="collapse " id="infectious-diseases-----hiv-10568" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/the-value-of-dynamic-transmission-models" data-drupal-link-system-path="node/33691">The value of dynamic transmission models</a> <div class="collapse " id="infectious-diseases------the-value-of-dynamic-transmission-models-10569" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights------nash-10571"></span> <a href="/insights/therapeutics/nash" data-drupal-link-system-path="node/33693">NASH</a> <div class="collapse " id="therapeutics-insights------nash-10571" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/nash/the-voice-of-nash-investigators-in-patient-recruitment" data-drupal-link-system-path="node/33694">The voice of NASH investigators</a> <div class="collapse " id="nash-the-voice-of-nash-investigators-10572" > </div> </li> </ul> </div> </li> <li> <a href="/insights/therapeutics/womens-health-insights" data-drupal-link-system-path="node/39166">Women's Health Insights</a> <div class="collapse " id="therapeutics-insights-------women-s-health-insights-11176" > </div> </li> <li> <a href="/insights/therapeutics/oncology" data-drupal-link-system-path="node/33698">Oncology</a> <div class="collapse " id="therapeutics-insights--------oncology-10576" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights---------pediatrics-10577"></span> <a href="/insights/therapeutics/pediatrics" data-drupal-link-system-path="node/33699">Pediatrics</a> <div class="collapse " id="therapeutics-insights---------pediatrics-10577" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/pediatrics/pediatric-risk-assessment-map" data-drupal-link-system-path="node/33700">Pediatric Risk Assessment Map</a> <div class="collapse " id="pediatrics-pediatric-risk-assessment-map-10578" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights----------rare-and-orphan-diseases-10579"></span> <a href="/insights/therapeutics/rare-and-orphan-diseases" data-drupal-link-system-path="node/33706">Rare and orphan diseases</a> <div class="collapse " id="therapeutics-insights----------rare-and-orphan-diseases-10579" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/pushing-boundaries-idiopathic-pulmonary" data-drupal-link-system-path="node/34969">Pushing boundaries in idiopathic pulmonary fibrosis clinical research</a> <div class="collapse " id="rare-and-orphan-diseases-pushing-boundaries-in-idiopathic-pulmonary-fibrosis-clinical-research-10861" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/advanced-therapies-for-rare-diseases" data-drupal-link-system-path="node/33701">Advanced therapies for rare diseases</a> <div class="collapse " id="rare-and-orphan-diseases--advanced-therapies-for-rare-diseases-10580" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/cross-border-enrollment-of-rare-disease-patients" data-drupal-link-system-path="node/33702">Cross-border enrollment of rare disease patients</a> <div class="collapse " id="rare-and-orphan-diseases---cross-border-enrollment-of-rare-disease-patients-10581" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/crossing-the-finish-line" data-drupal-link-system-path="node/33703">Crossing the finish line: Why effective participation support strategy is critical to trial efficiency and success in rare diseases</a> <div class="collapse " id="rare-and-orphan-diseases----crossing-the-finish-line-why-effective-participation-support-strategy-is-critical-to-trial-efficiency-and-success-in-rare-diseases-10582" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/diversity-equity-and-inclusion-in-rare-disease-trials" data-drupal-link-system-path="node/33704">Diversity, equity and inclusion in rare disease clinical trials</a> <div class="collapse " id="rare-and-orphan-diseases-----diversity-equity-and-inclusion-in-rare-disease-clinical-trials-10583" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/identify-and-mitigate-risks-to-rare-disease-clinical-programmes" data-drupal-link-system-path="node/33705">Identify and mitigate risks to rare disease clinical programmes</a> <div class="collapse " id="rare-and-orphan-diseases------identify-and-mitigate-risks-to-rare-disease-clinical-programmes-10584" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/leveraging-historical-data-for-use-in-rare-disease-trials" data-drupal-link-system-path="node/33707">Leveraging historical data for use in rare disease trials</a> <div class="collapse " id="rare-and-orphan-diseases-------leveraging-historical-data-for-use-in-rare-disease-trials-10585" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/natural-history-studies-to-improve-drug-development-in-rare-diseases" data-drupal-link-system-path="node/33708">Natural history studies to improve drug development in rare diseases</a> <div class="collapse " id="rare-and-orphan-diseases--------natural-history-studies-to-improve-drug-development-in-rare-diseases-10586" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/patient-centricity-in-orphan-drug-development" data-drupal-link-system-path="node/33709">Patient Centricity in Orphan Drug Development</a> <div class="collapse " id="rare-and-orphan-diseases---------patient-centricity-in-orphan-drug-development-10587" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/the-key-to-remarkable-rare-disease-registries" data-drupal-link-system-path="node/33710">The key to remarkable rare disease registries</a> <div class="collapse " id="rare-and-orphan-diseases----------the-key-to-remarkable-rare-disease-registries-10588" > </div> </li> </ul> </div> </li> </ul> </div> </li> </ul> </div> </div> </div> </div> <div class="contact-block d-none d-md-block"> <h4 class="border-top--green-dark mb-2 pt-2">Connect with us</h4> <ul class="list--icons"> <li> <a href="https://iconplc.com/contact/"> <i class="icon-ui-envelope"></i> <span>Contact us</span> </a> </li> <li> <a href="https://iconplc.com/contact/submit-rfp/"> <i class="icon-ui-document"></i> <span>Submit proposal request</span> </a> </li> <li> <a href="https://iconplc.com/preferences/"> <i class="icon-ui-preferences"></i> <span>Update Email Preferences</span> </a> </li> <li> <a href="https://iconplc.com/contact/global-office-locator/"> <i class="icon-ui-pin"></i> <span>Global office locator</span> </a> </li> <li> <a href="https://iconplc.com/news-events/social-media/"> <i class="icon-ui-social-media"></i> <span>ICON on social media</span> </a> </li> </ul> </div> </div> </div> </div> </div> </div> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div id="a406dd2c-4655-4b69-a38a-e1f8f59545f0"> <div class="group group--with-carousel bg-white content-visibility--auto contain-intrinsic-size--400 related-content-carousel"> <div class="container-fluid container-fluid--xl"> <div class="carousel--standard carousel--standard-1-3-4"> <a class="carousel__item block-link" href="/insights/therapeutics/central-nervous-system" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-green" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon-ui-arrow-right"></i> <span class="badge badge--with-arrow">Webpage</span> <h4 class="card-title m-0"> Therapeutic insights: CNS clinical trials </h4> </div> </div> </a> <a class="carousel__item block-link" href="/insights/blog/2020/12/04/harnessing-digital-health-to-advance-tbi-clinical-trials" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-yellow-green" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon-ui-arrow-right"></i> <span class="badge badge--with-arrow">Blog</span> <h4 class="card-title m-0"> Harnessing digital health to advance traumatic brain injury clinical trials </h4> </div> </div> </a> <a class="carousel__item block-link" href="https://www2.iconplc.com/article_patient_registries_for_neurodegenerative_disease" target="_blank"> <div class="card card--with-solid-bg card--with-solid-bg-green-dark" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon icon-download"></i> <span class="badge badge--with-arrow">Briefing</span> <h4 class="card-title m-0"> Patient Registries for Neurodegenerative Diseases </h4> </div> </div> </a> <a class="carousel__item block-link" href="https://www.iconplc.com/solutions/consulting/commercial-positioning-consulting/mapi-research-trust/" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-green" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon-ui-arrow-right"></i> <span class="badge badge--with-arrow">Webpage</span> <h4 class="card-title m-0"> Mapi Research Trust - the industry's largest library of COAs </h4> </div> </div> </a> <a class="carousel__item block-link" href="https://www.outsourcing-pharma.com/Article/2019/01/09/Parkinson-s-disease-clinical-trials-Challenges-advancements-and-the-role-of-technology" target="_blank"> <div class="card card--with-solid-bg card--with-solid-bg-blue-light" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon-ui-arrow-right"></i> <span class="badge badge--with-arrow">Media Article</span> <h4 class="card-title m-0"> Parkinson’s disease clinical trials: challenges, advancements, and the role of technology </h4> </div> </div> </a> <a class="carousel__item block-link" href="https://www2.iconplc.com/considerations_epilepsytrials" target="_blank"> <div class="card card--with-solid-bg card--with-solid-bg-cream" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon icon-download"></i> <span class="badge badge--with-arrow">Factsheet</span> <h4 class="card-title m-0"> Key considerations for epilepsy trials </h4> </div> </div> </a> <a class="carousel__item block-link" href="/news-events/press-releases/traumatic-brain-injury-study" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-blue" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon-ui-arrow-right"></i> <span class="badge badge--with-arrow">Press Release</span> <h4 class="card-title m-0"> ICON contributes to major study on treatment for Traumatic Brain Injury </h4> </div> </div> </a> <a class="carousel__item block-link" href="https://www2.iconplc.com/infographic_alzheimersdisease" target="_blank"> <div class="card card--with-solid-bg card--with-solid-bg-green-dark" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon icon-download"></i> <span class="badge badge--with-arrow">Infographic</span> <h4 class="card-title m-0"> Supporting research into Alzheimer’s Disease </h4> </div> </div> </a> <a class="carousel__item block-link" href="/insights/digital-disruption/mHealth-wearables" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-green" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon-ui-arrow-right"></i> <span class="badge badge--with-arrow">Webpage</span> <h4 class="card-title m-0"> mHealth & Wearables </h4> </div> </div> </a> <a class="carousel__item block-link" href="/insights/blog/2020/11/19/bringing-an-invisible-battle-to-the-forefront" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-yellow-green" data-mh="related-content"> <div class="card-body"> <i aria-hidden="true" class="icon-ui-arrow-right"></i> <span class="badge badge--with-arrow">Blog</span> <h4 class="card-title m-0"> How to better design military-related TBI clinical trials </h4> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </main> <footer role="contentinfo" class="footer"> <div class="footer__main-content"> <div class="container-fluid container-fluid--xl"> <div region="footer" class="row"> <div class="col-12 col-md-3"> <div class="h6 footer__nav-title">Site Branding</div> <ul class="footer__nav--secondary list-unstyled secondary-nav-title"> <img alt="ICON plc" title="ICON plc" class="footer__logo" height="38" src="/themes/custom/iconplc/src/assets/images/ICON_positive_logo.svg" width="138"> <li> <a href="/contact" data-drupal-link-system-path="node/33596">Contact</a> </li> <li> <a href="/about" data-drupal-link-system-path="node/33564">About ICON</a> </li> <li> <a href="https://investor.iconplc.com/financials-filings/annual-reports" target="_blank">Results & Reports</a> </li> </ul> </div> <div class="col-6 col-md-2"> <div class="h6 footer__nav-title">For Clients</div> <ul class="footer__nav--secondary list-unstyled secondary-nav-title"> <li> <a href="/therapeutics" data-drupal-link-system-path="node/34075">Therapeutics</a> </li> <li> <a href="/solutions" data-drupal-link-system-path="node/33933">Solutions</a> </li> <li> <a href="/insights" data-drupal-link-system-path="node/33625">Insights</a> </li> <li> <a href="/solutions/technologies" data-drupal-link-system-path="node/34042">Technologies</a> </li> <li> <a href="/preferences" data-drupal-link-system-path="node/33791">Content preferences</a> </li> <li> <a href="/contact/global-office-locator" data-drupal-link-system-path="node/33595">Office locations</a> </li> </ul> </div> <div class="col-6 col-md-2"> <div class="h6 footer__nav-title">ICON for</div> <ul class="footer__nav--secondary list-unstyled secondary-nav-title"> <li> <a href="https://www.accellacare.com/" target="_blank">Patients</a> </li> <li> <a href="https://iconstudies.com/" target="_blank">Volunteers</a> </li> <li> <a href="/investigators" data-drupal-link-system-path="node/33762">Investigators</a> </li> <li> <a href="https://careers.iconplc.com/" target="_blank">Jobs & Careers</a> </li> <li> <a href="https://investor.iconplc.com/" target="_blank">Investors</a> </li> <li> <a href="/procurement-terms/icon-suppliers">Suppliers</a> </li> </ul> </div> <div class="col-12 col-md-2"> <div class="h6 footer__nav-title">News & Events</div> <ul class="footer__nav--secondary list-unstyled secondary-nav-title"> <li> <a href="/news-events/press-releases" data-drupal-link-system-path="node/33789">Press releases</a> </li> <li> <a href="/news-events/mediakit" data-drupal-link-system-path="node/33787">Mediakit</a> </li> <li> <a href="/news-events/events" data-drupal-link-system-path="node/34258">Events</a> </li> <li> <a href="/news-events/social-media" data-drupal-link-system-path="node/33790">Social media dashboard</a> </li> </ul> </div> <div class="col-12 col-md-3"> <div class="h6 footer__nav-title">Socials</div> <ul class="footer__nav--secondary list-unstyled secondary-nav-title"> <li class="list-inline-item"> <a class="linkedin" href="https://www.linkedin.com/company/icon-plc-2" target="_blank" title="Icon on Linkedin"> <i aria-hidden="true" class="fa fa-linkedin"></i><span class="sr-only">Linkedin</span> </a> </li> <li class="list-inline-item"> <a class="x-twitter" href="https://twitter.com/ICONplc" target="_blank" title="Icon on Twitter"> <i aria-hidden="true" class="fa fa-x-twitter"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path d="M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z" fill="currentColor"/></svg> </i> </a> </li> <li class="list-inline-item"> <a class="facebook" href="https://www.facebook.com/icon.plc.profile" target="_blank" title="Icon on Facebook"> <i aria-hidden="true" class="fa fa-facebook"></i><span class="sr-only">Facebook</span> </a> </li> <li class="list-inline-item"> <a class="instagram" href="https://www.instagram.com/iconplc/" target="_blank" title="Icon on Instagram"> <i aria-hidden="true" class="fa fa-instagram"></i><span class="sr-only">Instagram</span> </a> </li> <li class="list-inline-item"> <a class="youtube" href="https://www.youtube.com/user/ICONPlc" target="_blank" title="Icon on Youtube"> <i aria-hidden="true" class="fa fa-youtube"></i><span class="sr-only">Youtube</span> </a> </li> </ul> </div> </div> </div> </div> <div class="copyright"> <div class="container-fluid container-fluid--xl"> <nav role="navigation" aria-labelledby="block-legalfooter-menu" id="block-legalfooter"> <h2 class="visually-hidden" id="block-legalfooter-menu">Legal Footer</h2> <ul region="legal_footer" class="list-inline"> <li class="list-inline-item"> <span>© 2024 ICON plc</span> </li> <li class="list-inline-item"> <a href="https://iconplc.com/disclaimer/">Disclaimer</a> </li> <li class="list-inline-item"> <a href="/privacy" data-drupal-link-system-path="node/33795">Privacy & Data</a> </li> <li class="list-inline-item"> <a href="https://iconplc.com/site-cookies/">Cookies</a> </li> </ul> </nav> </div> </div> </footer> </div> <div class="modal modal--ajax-search fade" id="search-modal" tabindex="-1" role="dialog" aria-labelledby="search-modal"> <div class="modal-dialog" role="document" id="searchApp"> <div class="modal-content"> <div class="modal-header"> <div class="h1 modal-title">How can we help?</div> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span class="sr-only">Dismiss Search Modal</span> </button> </div> <div class="modal-body"> <div class="region region-offscreen"> <div class="modal--ajax-search" id="block-searchblock"> <div class="modal-content"> <div id="icon-search-bar" class="icon-search-bar modal-body"> <form action="/live-search" autocomplete="off" id="site-search" role="search" class="form--simple-search"> <ul class="nav nav-tabs search-global-filter" role="tablist"> <li class="nav-item search-nav-tab"><a class="nav-link show-all active" data-display-id="all">All</a></li> <li class="nav-item search-nav-tab"><a class="nav-link" data-toggle="tab" href="#website" data-display-id="website">Website</a></li> </ul> <div class="search-results-input"> <div class="input-group"> <input class="form-control form-control--simple" id="icon-search-input" type="text" placeholder="Live search..."/> <span class="input-group-btn"> <button class="btn btn-lg btn-primary primary-search-button"><span class="icon-search-indicator icon-ui-search-loupe"></span><span class="sr-only">Search</span></button> </span> </div> </div> <div class="list-with-scroll"> <div class="popular-search-terms"> <div class="list-with-scroll__label"> Popular search terms:</div> <ul class="list-inline search-terms"> <li class="list-inline-item search-term"><a class="search-term-tag">Biotech</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Cell and Gene Therapies</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Consulting</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Early Clinical</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Medical Device</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Oncology</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Rare & Orphan Diseases</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Real World Evidence</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Site & Patient Recruitment</a></li> <li class="list-inline-item search-term"><a class="search-term-tag">Strategic Solutions</a></li> <li class="list-inline-item search-term"><a class="search-term-tag"> Regulatory Intelligence</a></li> </ul> </div> <div class="hide-global-filters global-filters-facet"> <label for="globalFilterReset" class="list-with-scroll__label">Categories</label> <button type="button" class="badge badge-primary global-filter-button" id="globalFilterReset"></button> </div> </div> <div class="taxonomy-term-facet-filter"></div> </form> <div class="tab-content"> <div id="website" class="p-0 container tab-pane active show"> <div id="icon-search-results--insights_block"></div> <div id="icon-search-results--other_web_pages"></div> </div> </div> </div> </div> </div> </div> </div> <div class="modal-footer"></div> </div> </div> </div> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/34068","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxtj1FywyAMRC9kmSN5BMiGRkaMgDTu6YvjNk5m_CXxdtFK6H0VTJvBv2acVVId8AsfEwt6UvPWjzWoWEs6OFEySXRFjj80RCdpKoTqgjnKE2V2xqF6gO9YAxTh6MEu75q0QgxQKibfnS9pjkzgZM2SqC_0jxcWi9ztG8d0DtorzCK1r_bBlh6QP1Gg_ZQX4_6ESo8zI6uscpF98Hv0dKUeZ4NlcbcTdrNFvbDviZCjq00JnvkgibeBcZNWJx-LkzvpZvo3JzxkVFwUcyjGa8vI40nGlnKzHEsgP5StVFqNxUK_Awi4ng","theme":"iconplc","theme_token":null},"ajaxTrustedUrl":[],"ajaxLoader":{"markup":"\u003Cdiv class=\u0022ajax-throbber sk-circle-fade\u0022\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003Cdiv class=\u0022sk-circle-fade-dot\u0022\u003E\u003C\/div\u003E\n \u003C\/div\u003E","hideAjaxMessage":true,"alwaysFullscreen":true,"throbberPosition":".acquia-dam-media-library"},"clientside_validation_jquery":{"validate_all_ajax_forms":2,"force_validate_on_blur":false,"messages":{"required":"This field is required.","remote":"Please fix this field.","email":"Please enter a valid email address.","url":"Please enter a valid URL.","date":"Please enter a valid date.","dateISO":"Please enter a valid date (ISO).","number":"Please enter a valid number.","digits":"Please enter only digits.","equalTo":"Please enter the same value again.","maxlength":"Please enter no more than {0} characters.","minlength":"Please enter at least {0} characters.","rangelength":"Please enter a value between {0} and {1} characters long.","range":"Please enter a value between {0} and {1}.","max":"Please enter a value less than or equal to {0}.","min":"Please enter a value greater than or equal to {0}.","step":"Please enter a multiple of {0}."}},"searchPageUrl":"\/live-search","csp":{"nonce":"UZG7KGwKQUiMRCAS6vsNlQ"},"user":{"uid":0,"permissionsHash":"f01f36190caa010d94e570540a4b4f3142bad09d60a47161bcbb58d60194bee8"}}</script> <script src="/sites/default/files/js/js_4eyK4OIDo-cHA2vFhqDgYHqy_-DGeewODAUoq8QSoxA.js?scope=footer&delta=0&language=en&theme=iconplc&include=eJx1UdGSwyAI_KEQPymDSqJXIg5qr97Xn03v0s5N7wlY2GVR9L4Kpm7wJ5lXlVQn_MDbwoKe1Lzkcw0q1pJOpZdKu7FYaHKiZJLojhy_aIpOUmZnNhaLDKV2jmk74KUQqgvmEc7JRwmWxV1O8B5hFaljG2OXVhcfi5MraTeSyAlPGRU3xRyK8doy8vxE5pZysxxLIH-KOlQP8BlrgCIcPdjttSetEMOwjMmPyafB6MmigpM9j9XjgX47lW4VcnS1KQEclSTuZz-r7ALXwZc37DUyvYGP07fhJp8QE_pD_o_yP-RA9-_6Biv6uJ4"></script> <script src="https://static.addtoany.com/menu/page.js" async></script> <script src="/sites/default/files/js/js_Mmd91oLJSr76pFTaSpKRllfbKRQ6_UqOZnE13OwVj8M.js?scope=footer&delta=2&language=en&theme=iconplc&include=eJx1UdGSwyAI_KEQPymDSqJXIg5qr97Xn03v0s5N7wlY2GVR9L4Kpm7wJ5lXlVQn_MDbwoKe1Lzkcw0q1pJOpZdKu7FYaHKiZJLojhy_aIpOUmZnNhaLDKV2jmk74KUQqgvmEc7JRwmWxV1O8B5hFaljG2OXVhcfi5MraTeSyAlPGRU3xRyK8doy8vxE5pZysxxLIH-KOlQP8BlrgCIcPdjttSetEMOwjMmPyafB6MmigpM9j9XjgX47lW4VcnS1KQEclSTuZz-r7ALXwZc37DUyvYGP07fhJp8QE_pD_o_yP-RA9-_6Biv6uJ4"></script> </body> </html>