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CNS Neurology | ICON plc

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Our solutions make it convenient for the patient to complete the protocol assessments and stay engaged throughout the clinical study.</p> <p>ICON <a href="/solutions/decentralised-clinical-trials/In-home-clinical-services/" target="_self">In-Home and Alternate Site Clinical Solutions</a> plus the use of telemedicine technology and <a href="/solutions/technologies/firecrest" target="_self">FIRECREST</a> eViewer and eConsent, allow for a most patient-friendly study set-up – in the past five years, ICON's Symphony Clinical Research has supported 57 studies in neurology with in-home clinical trial services</p> <p><a href="https://www.accellacare.com/" target="_blank">Accellacare</a>, <a href="/solutions/site-and-patient-solutions/clinical-site-solutions/" target="_self">ICON's Global Site Network</a> includes 55 CNS specialised sites across the globe with a proven track record in studies in neurodegeneration for rapid start-up, competent execution and patient access. We use these sites to evaluate the site and patient burden of a protocol prior to it being finalised.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="50c7d54b-2f12-452b-b93c-deb3262604c8" class="icon-group icon-group--horizontal"> <div class="container-fluid container-fluid--xl"> <h2 class="icon-group__title">ICON neurodegenerative and neuromuscular experience in last five years</h2> <ul class="icon-group__items icon-group__items__columns-3"> <li class="icon-group__item--blue"> <div lang="en" class="icon-group__wrapper" > <i class="icon-content-development"></i> <p class="mb-2 icons-large-text">167</p> <small>Neurodegenerative and neuromuscular clinical studies</small> </div> </li> <li class="icon-group__item--green-bright"> <div lang="en" class="icon-group__wrapper" > <i class="icon-patient"></i> <p class="mb-2 icons-large-text">18,650+</p> <small>neurodegenerative and neuromuscular patients and healthy volunteers (HV)</small> </div> </li> <li class="icon-group__item--blue-light"> <div lang="en" class="icon-group__wrapper" > <i class="icon-global"></i> <p class="mb-2 icons-large-text">4,200+</p> <small>sites globally</small> </div> </li> </ul> </div> </div> <div id="16d0f068-0416-4e65-8af4-1a925dda7c7a"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/factsheet_neurodegenerative_diseases" target="_blank" title="Brochure: Neurodegenerative diseases"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/5499b91a-f652-4f7b-83c5-7fd88e18028c/web/11084-Neurodegenerative-Diseases-Factsheet_Thumbnail.jpg?h=240&amp;itok=kDEfxYvp" width="170" height="240" alt="11084-Neurodegenerative-Diseases-Factsheet_Thumbnail.jpg" loading="lazy" title="11084-Neurodegenerative-Diseases-Factsheet_Thumbnail.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Brochure: Neurodegenerative diseases</h3> <p>Our broad expertise in neurodegeneration encompasses multiple indications, including: Adrenoleukodystrophy, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Diabetic Peripheral Neuropathy, Familial Amyloid Polyneuropathy, Huntington’s Disease, Metachromatic Leukodystrophy, Multiple Sclerosis, Multiple System Atrophy, Parkinson’s Disease, Progressive Supranuclear Palsy, Spasticity</p> </span> </a> </div> </div> </div> </div> <div id="d874d205-f065-4a63-9803-ec048e8dc9f9"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/Factsheet_ICONIK_RSA" target="_blank" title="ICONIK Rating Scale Analytics"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/b352667f-c1df-4614-84a6-32908985df8e/web/Factsheet-ICONIK-RSA.jpg?h=240&amp;itok=WCdZXkF8" width="170" height="240" alt="Factsheet-ICONIK-RSA.jpg" loading="lazy" title="Factsheet-ICONIK-RSA.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>ICONIK Rating Scale Analytics</h3> <p>ICONIK Rating Scale and eCOA Analytics Solution (RSA) is an advanced suite of data visualisation and analytics tools developed to drive quality, consistency and objectivity in rating scales and patient reported or patient centric data.</p> </span> </a> </div> </div> </div> </div> <div id="a89b56ed-57bb-401e-9635-5edd46e879b3"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> Wet, imaging and digital biomarker neurology endpoints </h3> <div> <p>ICON has all relevant services for wet, imaging and digital biomarker endpoints in house:</p> <p>ICON <a href="/solutions/laboratories/bioanalytical-laboratories/" target="_self">Bioanalytical Laboratories</a> support the development and analysis of biomarker assays in the neurodegenerative disease space including determination of A-B 1-42, Total tau, Phospho tau, NFL, APOE Geno, and APOE.</p> <p>ICON <a href="/solutions/imaging/" target="_self">Medical Imaging</a> has supported 20+ studies in neurodegenerative indications and provides rigorous analysis of novel imaging endpoints and surrogate markers.</p> <p>ICON provides an end-to-end approach to effective <a href="/insights/digital-disruption/mHealth-wearables/" target="_self">integration of wearable devices into trial design, execution and reporting</a>. Our digital health technology team has experience developing such frameworks - from device selection to endpoint generation and operational management.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div><div id="b90ed605-e85f-4b49-820a-7ce2623d97bb"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/Case_Study_Parkinson%E2%80%99s_disease_recruitment" target="_blank" title="Overcoming recruitment challenges - Parkinson&#039;s Case Study"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/36c175c1-4fac-496a-91e4-586cf5c9fae0/web/Case%20study_Parkinsons_thumbnail.png?h=240&amp;itok=8NhxANZW" width="170" height="240" alt="Case study_Parkinsons_thumbnail.png" loading="lazy" title="Case study_Parkinsons_thumbnail.png" /> </div> </div> </div> </span> <span class="file__details"> <h3>Overcoming recruitment challenges - Parkinson&#039;s Case Study</h3> <p>Parkinson disease (PD) is highly prevalent among neurodegenerative diseases, affecting a diverse patient population. Despite a general willingness of patients to participate in clinical trials, only a subset of patients enroll in them.</p> </span> </a> </div> </div> </div> </div> <div id="bbd240d4-9201-4b23-8b7e-b6024e8e0484"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/whitepaper_traumatic_brain_injury" target="_blank" title="Traumatic Brain Injury: From identifying biomarkers to improving clinical trial efficiency"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/733936a5-2599-49af-9c39-56d0a6b6bdac/web/Whitepaper_Traumatic_Brain_Injury_TBI_Thumbnails.jpg?h=240&amp;itok=RK5XBBJa" width="170" height="240" alt="Whitepaper_Traumatic_Brain_Injury_TBI_Thumbnails.jpg" loading="lazy" title="Whitepaper_Traumatic_Brain_Injury_TBI_Thumbnails.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Traumatic Brain Injury: From identifying biomarkers to improving clinical trial efficiency</h3> <p>This whitepaper explores the impact of TBI on different populations as well as challenges and opportunities in clinical research.</p> </span> </a> </div> </div> </div> </div> <div id="ee20fb65-eb6d-4320-bf18-5ae5c07ee0e1"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="https://www2.iconplc.com/Infographic_Traumatic_Brain_Injury" target="_blank" title="Traumatic Brain Injury infographic"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/6460979a-a567-475b-a278-7d6f46bcae01/web/11397-TBI-Whitepaper_Infographic.jpg?h=240&amp;itok=rDJrXZwz" width="170" height="240" alt="11397-TBI-Whitepaper_Infographic.jpg" loading="lazy" title="11397-TBI-Whitepaper_Infographic.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Traumatic Brain Injury infographic</h3> <p>This infographic is a visual summary of the above TBI whitepaper</p> </span> </a> </div> </div> </div> </div> <div id="44150154-9901-48d8-9306-35b1e2f585a5"> <div> <div class="file file--with-thumbnail"> <div class="container-fluid container-fluid--xl"> <a href="/insights/therapeutics/central-nervous-system/key-considerations-for-parkinsons-disease-trials" target="_self" title="Whitepaper: Key considerations for Parkinson’s disease trials"> <span class="file__thumbnail"> <div> <div><div><img src="https://icon.widen.net/content/0f8bfd6c-bb5f-4ad4-bf4e-060224825409/web/WP-Parkinsons_Disease.jpg?h=240&amp;itok=_-DI9veg" width="170" height="240" alt="WP-Parkinsons_Disease.jpg" loading="lazy" title="WP-Parkinsons_Disease.jpg" /> </div> </div> </div> </span> <span class="file__details"> <h3>Whitepaper: Key considerations for Parkinson’s disease trials</h3> <p>Download the whitepaper</p> </span> </a> </div> </div> </div> </div> <div id="3103f8c5-b233-4afd-a6c4-4e960b674ed4"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> Cell and gene therapies for neurodegenerative diseases </h3> <div> <p>Clinical gene therapy has emerged as an innovative therapeutic strategy for a wide range of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and <a href="/therapeutics/rare-and-orphan-diseases/" target="_self">rare diseases</a> such as Huntington’s disease or Amyotrophic lateral sclerosis. ICON has a deep understanding of the specific regulatory, clinical and operational challenges of<a href="/therapeutics/cell-and-gene-therapies/" target="_self"> Cell and Gene Therapy clinical trials</a> having conducted 135 such studies, including 3 very recently in the neurodegenerative space.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="aa8ec77d-3ee3-4d8c-98fb-cb7f6b496655"> <div class="bg-gray"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h2>CNS, pain and ageing related disorders insights</h2> <h3> </h3> <div> <p>ICON's experienced neuroscience and drug development teams regularly share their insights in industry publications and through ICON produced content in the form of blogs and whitepapers. Read more content from our experts.</p> </div> <a class="btn btn-primary btn-md" href="/insights/therapeutics/central-nervous-system" target="_self">Read more </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </second> </div> <div class="col-md-3 order-1"> <div id="8090126b-2753-40c0-849a-79947e0b0848"> <div class="container-fluid container-fluid--xl sidebar-menu-wrapper"> <div class="sidebar"> <div class="sidebar sidebar--sticky sidebar--collapsible"> <a class="sidebar--collapsible__toggle collapsed" role="button" data-toggle="collapse" href="#sidebar-content" aria-expanded="false" aria-controls="sidebar-content"> <span>In this section</span> </a> <div class="sidebar--collapsible__content collapse" id="sidebar-content"> <div class="sidebar--menu"> <h6 class="d-none d-md-block">In this section</h6> <ul class="sidebar--collapsible__list"> <li> <a href="/therapeutics/biosimilars" data-drupal-link-system-path="node/33807">Biosimilars</a> <div class="collapse " id="biosimilars-10484" > </div> </li> <li> <a href="/therapeutics/cardiovascular" title="ICON has extensive experience in cardiovascular clinical research trials across the entire drug development spectrum." data-drupal-link-system-path="node/34066">Cardiovascular</a> <div class="collapse " id="cardiovascular-10511" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#cell-and-gene-therapies-10512"></span> <a href="/therapeutics/cell-and-gene-therapies" data-drupal-link-system-path="node/34067">Cell and Gene Therapies</a> <div class="collapse " id="cell-and-gene-therapies-10512" > <ul class="menu menu-level-1"> <li> <a href="/insights/value-based-healthcare/the-affordability-hurdle-for-gene-therapies" data-drupal-link-system-path="node/33755">The affordability hurdle for gene therapies</a> <div class="collapse " id="cell-and-gene-therapies-the-affordability-hurdle-for-gene-therapies-10513" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class=" " data-toggle="collapse" role="button" href="#central-nervous-system-10514"></span> <a href="/therapeutics/central-nervous-system" data-drupal-link-system-path="node/34071">Central Nervous System</a> <div class="collapse show" id="central-nervous-system-10514" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/central-nervous-system/cns-neurology" class="active is-active" data-drupal-link-system-path="node/34068">CNS Neurology</a> <div class="collapse show" id="central-nervous-system-cns-neurology-10515" > </div> </li> <li> <a href="/therapeutics/central-nervous-system/cns-pain" data-drupal-link-system-path="node/34069">CNS Pain</a> <div class="collapse " id="central-nervous-system--cns-pain-10516" > </div> </li> <li> <a href="/therapeutics/central-nervous-system/cns-psychiatry" data-drupal-link-system-path="node/34070">CNS Psychiatry</a> <div class="collapse " id="central-nervous-system---cns-psychiatry-10517" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials" data-drupal-link-system-path="node/33678">Challenges and opportunities in traumatic brain injury clinical trials</a> <div class="collapse " id="central-nervous-system----challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials-10518" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-for-parkinsons-disease-trials" data-drupal-link-system-path="node/33680">Challenges and opportunities in Parkinson’s Disease clinical trials</a> <div class="collapse " id="central-nervous-system-----challenges-and-opportunities-in-parkinson-s-disease-clinical-trials-10519" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-in-chronic-pain-clinical-trials" data-drupal-link-system-path="node/33681">Key considerations in chronic pain clinical trials</a> <div class="collapse " id="central-nervous-system------key-considerations-in-chronic-pain-clinical-trials-10520" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#endocrine-metabolic-disorders-10521"></span> <a href="/therapeutics/endocrine-metabolic-disorders" data-drupal-link-system-path="node/34072">Endocrine &amp; Metabolic Disorders</a> <div class="collapse " id="endocrine-metabolic-disorders-10521" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/endocrine-metabolic-disorders/obesity" data-drupal-link-system-path="node/38991">Obesity</a> <div class="collapse " id="endocrine-metabolic-disorders-obesity-11021" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#endocrine-metabolic-disorders--metabolic-dysfunction-associated-steatohepatitis-mash--10522"></span> <a href="/therapeutics/endocrine-metabolic-disorders/non-alcoholic-steatohepatitis-nash" data-drupal-link-system-path="node/34073">Metabolic dysfunction-associated steatohepatitis (MASH)</a> <div class="collapse " id="endocrine-metabolic-disorders--metabolic-dysfunction-associated-steatohepatitis-mash--10522" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/nash/the-voice-of-nash-investigators-in-patient-recruitment" data-drupal-link-system-path="node/33694">The voice of NASH investigators</a> <div class="collapse " id="metabolic-dysfunction-associated-steatohepatitis-mash--the-voice-of-nash-investigators-10523" > </div> </li> </ul> </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#infectious-diseases-10524"></span> <a href="/therapeutics/infectious-diseases" data-drupal-link-system-path="node/34076">Infectious Diseases</a> <div class="collapse " id="infectious-diseases-10524" > <ul class="menu menu-level-1"> <li> <a href="/insights/therapeutics/infectious-diseases/antimicrobial-resistance" data-drupal-link-system-path="node/33685">Antimicrobial resistance</a> <div class="collapse " id="infectious-diseases-antimicrobial-resistance-10525" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/hiv" data-drupal-link-system-path="node/33689">HIV</a> <div class="collapse " id="infectious-diseases--hiv-10526" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccine-trials" data-drupal-link-system-path="node/33687">Pandemic respiratory vaccine clinical trials</a> <div class="collapse " id="infectious-diseases---pandemic-respiratory-vaccine-clinical-trials-10527" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#internal-medicine-immunology-10528"></span> <a href="/therapeutics/internal-medicine-immunology" data-drupal-link-system-path="node/34080">Internal Medicine &amp; Immunology</a> <div class="collapse " id="internal-medicine-immunology-10528" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/internal-medicine-and-immunology/dermatology" data-drupal-link-system-path="node/34077">Dermatology</a> <div class="collapse " id="internal-medicine-immunology-dermatology-10529" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#internal-medicine-immunology--gastrointestinal-10530"></span> <a href="/therapeutics/internal-medicine-immunology/gastrointestinal" data-drupal-link-system-path="node/34078">Gastrointestinal</a> <div class="collapse " id="internal-medicine-immunology--gastrointestinal-10530" > <ul class="menu menu-level-2"> <li> <a href="/therapeutics/internal-medicine-and-immunology/gastrointestinal/inflammatory-bowel-disease" data-drupal-link-system-path="node/34079">Inflammatory Bowel Disease</a> <div class="collapse " id="gastrointestinal-inflammatory-bowel-disease-10531" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/ophthalmology" data-drupal-link-system-path="node/34081">Ophthalmology</a> <div class="collapse " id="internal-medicine-immunology---ophthalmology-10532" > </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/respiratory" data-drupal-link-system-path="node/34082">Respiratory</a> <div class="collapse " id="internal-medicine-immunology----respiratory-10533" > </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/rheumatology" data-drupal-link-system-path="node/34083">Rheumatology</a> <div class="collapse " id="internal-medicine-immunology-----rheumatology-10534" > </div> </li> <li> <a href="/therapeutics/internal-medicine-immunology/transplant-immunology" data-drupal-link-system-path="node/34091">Transplant Immunology</a> <div class="collapse " id="internal-medicine-immunology------transplant-immunology-10544" > </div> </li> <li> <a href="/therapeutics/internal-medicine-and-immunology/urology" data-drupal-link-system-path="node/34084">Urology</a> <div class="collapse " id="internal-medicine-immunology-------urology-10535" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/medical-device" data-drupal-link-system-path="node/34085">Medical Device</a> <div class="collapse " id="medical-device-10536" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#oncology-10537"></span> <a href="/therapeutics/oncology" data-drupal-link-system-path="node/34088">Oncology</a> <div class="collapse " id="oncology-10537" > <ul class="menu menu-level-1"> <li> <a href="/therapeutics/oncology/early-phase-oncology" data-drupal-link-system-path="node/34086">Early Phase Oncology</a> <div class="collapse " id="oncology-early-phase-oncology-10538" > </div> </li> <li> <a href="/therapeutics/oncology/immuno-oncology" data-drupal-link-system-path="node/34087">Immuno-Oncology</a> <div class="collapse " id="oncology--immuno-oncology-10539" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/pediatrics" data-drupal-link-system-path="node/34089">Pediatrics</a> <div class="collapse " id="pediatrics-10540" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#rare-orphan-diseases-10541"></span> <a href="/therapeutics/rare-orphan-diseases" data-drupal-link-system-path="node/34090">Rare &amp; Orphan Diseases</a> <div class="collapse " id="rare-orphan-diseases-10541" > <ul class="menu menu-level-1"> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/leveraging-historical-data-for-use-in-rare-disease-trials" data-drupal-link-system-path="node/33707">Leveraging historical data for use in rare disease trials</a> <div class="collapse " id="rare-orphan-diseases-leveraging-historical-data-for-use-in-rare-disease-trials-10542" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/patient-centricity-in-orphan-drug-development" data-drupal-link-system-path="node/33709">Patient centricity in orphan drug development</a> <div class="collapse " id="rare-orphan-diseases--patient-centricity-in-orphan-drug-development-10543" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#vaccines-10546"></span> <a href="/therapeutics/vaccines" data-drupal-link-system-path="node/34092">Vaccines</a> <div class="collapse " id="vaccines-10546" > <ul class="menu menu-level-1"> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccine-trials" data-drupal-link-system-path="node/33687">Pandemic respiratory vaccine clinical trials</a> <div class="collapse " id="vaccines-pandemic-respiratory-vaccine-clinical-trials-10547" > </div> </li> </ul> </div> </li> <li> <a href="/therapeutics/womens-health" data-drupal-link-system-path="node/34094">Women&#039;s Health</a> <div class="collapse " id="women-s-health-10545" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-10548"></span> <a href="/insights/therapeutics" data-drupal-link-system-path="node/33684">Therapeutics insights</a> <div class="collapse " id="therapeutics-insights-10548" > <ul class="menu menu-level-1"> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" 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