CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Melvin Berger - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="RO2HrWEtXLC7_PmZB57WGQH-UP2wRl6OaA68pDuOUJ3swjlLskxgE0I-xhmOe3wq3UiHCEtdN_Kq2hFRlJS-fQ" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-3d36c19b4875b226bfed0fcba1dcea3f2fe61148383d97c0465c016b8c969290.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-79e78ce59bef0a338eb6540ec3d93b4a7952115b56c57f1760943128f4544d42.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-95367dc03b794f6737f30123738a886cf53b7a65cdef98a922a98591d60063e3.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-bfbac2a470372e2f3a6661a65fa7ff0a0fbf7aa32534d9a831d683d2a6f9e01b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-170d1319f0e354621e81ca17054bb147da2856ec0702fe440a99af314a6338c5.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="melvin berger" /> <meta name="description" content="Melvin Berger: 26 Followers, 2 Following, 125 Research papers. Research interests: Life Style, Economic analysis, and Rabbits." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = 'b092bf3a3df71cf13feee7c143e83a57eb6b94fb'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14016,"monthly_visitors":"99 million","monthly_visitor_count":99567017,"monthly_visitor_count_in_millions":99,"user_count":283026384,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1739836992000); window.Aedu.timeDifference = new Date().getTime() - 1739836992000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-40698df34f913bd208bb70f09d2feb7c6286046250be17a4db35bba2c08b0e2f.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-a22f75d8519394c21253dae46c8c5d60ad36ea68c7d494347ec64229d8c1cf85.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-5708a105dd66b4c7d0ef30b7c094b1048423f0042bd2a7b123f2d99ee3cf46d9.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/BergerMelvin" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-c0b60aedadfb9d46b698730fbbcb2e70645c886b405d825adeba3a031c02455d.js" defer="defer"></script><script>$viewedUser = Aedu.User.set_viewed( {"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":7471,"name":"Life Style","url":"https://www.academia.edu/Documents/in/Life_Style"},{"id":93836,"name":"Economic analysis","url":"https://www.academia.edu/Documents/in/Economic_analysis"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/BergerMelvin","location":"/BergerMelvin","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/BergerMelvin","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-42f25b94-5f0b-4a36-9e79-379bd1b426e2"></div> <div id="ProfileCheckPaperUpdate-react-component-42f25b94-5f0b-4a36-9e79-379bd1b426e2"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Melvin Berger</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Melvin" data-follow-user-id="38990937" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="38990937"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">26</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">2</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">2</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/BergerMelvin/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/ElizabethMu%C3%B1ozHorney"><img class="profile-avatar u-positionAbsolute" alt="Elizabeth Mu帽oz Horney" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/190496813/53626209/41756596/s200_elizabeth.mu_oz_horney.jpeg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/ElizabethMu%C3%B1ozHorney">Elizabeth Mu帽oz Horney</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ulaval.academia.edu/SylvainBourgoin"><img class="profile-avatar u-positionAbsolute" alt="Sylvain Bourgoin" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/37466348/10698797/11943717/s200_sylvain.bourgoin.jpeg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://ulaval.academia.edu/SylvainBourgoin">Sylvain Bourgoin</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Universit茅 Laval</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/AdrianGear"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/AdrianGear">Adrian Gear</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/PaulEggleton"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/PaulEggleton">Paul Eggleton</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/RichardHarrison72"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/RichardHarrison72">Richard Harrison</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/KjeldsenLars"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/KjeldsenLars">Lars Kjeldsen</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/ImadNadra"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/ImadNadra">Imad Nadra</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/%C3%81gnesKittel"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/%C3%81gnesKittel">脕gnes Kittel</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/FrancescaPolverino"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/FrancescaPolverino">Francesca Polverino</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://hms-harvard.academia.edu/CarolineOwen"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://hms-harvard.academia.edu/CarolineOwen">Caroline Owen</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Harvard Medical School</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38990937" href="https://www.academia.edu/Documents/in/Life_Style"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/BergerMelvin","location":"/BergerMelvin","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/BergerMelvin","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Life Style"]}" data-trace="false" data-dom-id="Pill-react-component-30d807c9-157b-4583-aa5f-59fa02c891e6"></div> <div id="Pill-react-component-30d807c9-157b-4583-aa5f-59fa02c891e6"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38990937" href="https://www.academia.edu/Documents/in/Economic_analysis"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Economic analysis"]}" data-trace="false" data-dom-id="Pill-react-component-9b480568-eaf4-4fc2-88f1-9288ac57b039"></div> <div id="Pill-react-component-9b480568-eaf4-4fc2-88f1-9288ac57b039"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38990937" href="https://www.academia.edu/Documents/in/Rabbits"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Rabbits"]}" data-trace="false" data-dom-id="Pill-react-component-007ef3b7-1d62-40e9-b6f1-a170b31c5411"></div> <div id="Pill-react-component-007ef3b7-1d62-40e9-b6f1-a170b31c5411"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="38990937" href="https://www.academia.edu/Documents/in/Chronic_Disease"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Chronic Disease"]}" data-trace="false" data-dom-id="Pill-react-component-c2e00862-0be4-4df2-a46f-b4fb02619da3"></div> <div id="Pill-react-component-c2e00862-0be4-4df2-a46f-b4fb02619da3"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Melvin Berger</h3></div><div class="js-work-strip profile--work_container" data-work-id="48834432"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834432/Isolation_and_Characterization_of_Complement_Receptor_Type_1_CR1_Storage_Vesicles_From_Human_Neutrophils_Using_Antibodies_to_the_Cytoplasmic_Tail_of_CR1"><img alt="Research paper thumbnail of Isolation and Characterization of Complement Receptor Type 1 (CR1) Storage Vesicles From Human Neutrophils Using Antibodies to the Cytoplasmic Tail of CR1" class="work-thumbnail" src="https://attachments.academia-assets.com/67253852/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834432/Isolation_and_Characterization_of_Complement_Receptor_Type_1_CR1_Storage_Vesicles_From_Human_Neutrophils_Using_Antibodies_to_the_Cytoplasmic_Tail_of_CR1">Isolation and Characterization of Complement Receptor Type 1 (CR1) Storage Vesicles From Human Neutrophils Using Antibodies to the Cytoplasmic Tail of CR1</a></div><div class="wp-workCard_item"><span>Blood</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neutrophil (PMN) activation is associated with increased surface expression of several membrane p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neutrophil (PMN) activation is associated with increased surface expression of several membrane proteins that are translocated from intracellular pools. Indirect evidence suggests that the intracellular storage pools of complement receptor type 1 (CR1) in resting PMN are distinct from traditional granules and may be the secretory vesicles in which albumin is also stored, but it is not known if this compartment is homogeneous or heterogeneous. To isolate and characterize the CR1-containing vesicles, we used antibodies against unique sequences in the cytoplasmic tail of CR1. Affinity-purified IgG was used to adsorb CR1 storage vesicles from the light membrane fraction (纬-band) of nitrogen cavitates of resting PMN. The immunoadsorbent could quantitatively remove the CR1-containing vesicles, whereas control adsorbents with nonimmune IgG showed no specific binding of CR1. Immunoblots of specifically isolated vesicles also showed enrichment of albumin, decay-accelerating factor, Fc纬RIII, ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f4618ea5165916ed4adac9f40e156c4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253852,"asset_id":48834432,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253852/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834432"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834432"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834432; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834432]").text(description); $(".js-view-count[data-work-id=48834432]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834432; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834432']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f4618ea5165916ed4adac9f40e156c4d" } } $('.js-work-strip[data-work-id=48834432]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834432,"title":"Isolation and Characterization of Complement Receptor Type 1 (CR1) Storage Vesicles From Human Neutrophils Using Antibodies to the Cytoplasmic Tail of CR1","internal_url":"https://www.academia.edu/48834432/Isolation_and_Characterization_of_Complement_Receptor_Type_1_CR1_Storage_Vesicles_From_Human_Neutrophils_Using_Antibodies_to_the_Cytoplasmic_Tail_of_CR1","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253852,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253852/thumbnails/1.jpg","file_name":"4555.pdf","download_url":"https://www.academia.edu/attachments/67253852/download_file","bulk_download_file_name":"Isolation_and_Characterization_of_Comple.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253852/4555-libre.pdf?1620414306=\u0026response-content-disposition=attachment%3B+filename%3DIsolation_and_Characterization_of_Comple.pdf\u0026Expires=1739840592\u0026Signature=MRExkrsvi3O0bGWBREdtT6BRYjg5P2~5io75JMifoQ8zqekXWnNLgL1LYRF-4hs-esH3uFbrPFCO4Mv~m80I~oljPS-5DkTrimnzjAk30sE1BQklK0TQpbdfJ63qpqom4pDJnArbBaNUg75qcop5BCCKvqe-2nA17lQKZ3FuD7NZp2p2Thrg45lMmNOiIp2jANYpGCIOUqdm56HWh~9hz38ZS42W5F0v4pV2eelgXyaIfTDnWrnVJiXQ9blF1eO7pe~1jpj~15KvVMzDSUEoYKAh86XGW12GhxWnNHeuG606MCgeNwGoC40by~qIWRlurQVqBe3m6iq0YT85bZ1YVg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834431"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834431/Update_on_C1_Esterase_Inhibitor_C1_INH_in_Human_Solid_Organ_Transplantation"><img alt="Research paper thumbnail of Update on C1 Esterase Inhibitor (C1-INH) in Human Solid Organ Transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834431/Update_on_C1_Esterase_Inhibitor_C1_INH_in_Human_Solid_Organ_Transplantation">Update on C1 Esterase Inhibitor (C1-INH) in Human Solid Organ Transplantation</a></div><div class="wp-workCard_item"><span>Transplantation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834431"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834431"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834431; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834431]").text(description); $(".js-view-count[data-work-id=48834431]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834431; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834431']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834431]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834431,"title":"Update on C1 Esterase Inhibitor (C1-INH) in Human Solid Organ Transplantation","internal_url":"https://www.academia.edu/48834431/Update_on_C1_Esterase_Inhibitor_C1_INH_in_Human_Solid_Organ_Transplantation","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834430"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834430/Alpha_1_antitrypsin_in_cell_and_organ_transplantation"><img alt="Research paper thumbnail of Alpha-1-antitrypsin in cell and organ transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/67253893/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834430/Alpha_1_antitrypsin_in_cell_and_organ_transplantation">Alpha-1-antitrypsin in cell and organ transplantation</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite significant advances in surgical technique and immunosuppression, challenges continue to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite significant advances in surgical technique and immunosuppression, challenges continue to restrict the number of transplants. Although the number of transplants performed each year in the United States is increasing, the number of people on waiting lists has nearly doubled in the past 15 years. 1 Improving the viability of donor organs by reducing the damage caused by ischemia-reperfusion injury (IRI) and activation of the innate immune system are thus key areas of ongoing research. Alpha-1-antitrypsin (AAT) is a serine protease inhibitor and acute phase reactant produced mainly by the liver that limits tissue damage caused by neutrophil elastase and other extracellular enzymes. 2-4 Consistent with this role, plasma concentrations of AAT can increase up to 4-fold in response to inflammatory stimuli. Mutations in AAT can cause emphysema due to deficiency in circulating AAT, and/or liver disease likely due to a "misfolded protein response." 2-4 AAT-deficient patients may also experience extrapulmonary pathologies, particularly panniculitis</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa7859e322f4593e08a5b5184be77ea9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253893,"asset_id":48834430,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253893/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834430"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834430"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834430; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834430]").text(description); $(".js-view-count[data-work-id=48834430]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834430; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834430']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa7859e322f4593e08a5b5184be77ea9" } } $('.js-work-strip[data-work-id=48834430]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834430,"title":"Alpha-1-antitrypsin in cell and organ transplantation","internal_url":"https://www.academia.edu/48834430/Alpha_1_antitrypsin_in_cell_and_organ_transplantation","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253893,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253893/thumbnails/1.jpg","file_name":"fullpdf.pdf","download_url":"https://www.academia.edu/attachments/67253893/download_file","bulk_download_file_name":"Alpha_1_antitrypsin_in_cell_and_organ_tr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253893/fullpdf-libre.pdf?1620414308=\u0026response-content-disposition=attachment%3B+filename%3DAlpha_1_antitrypsin_in_cell_and_organ_tr.pdf\u0026Expires=1739840592\u0026Signature=LR45YnIXD-5h0Xq9FJiJ3r7Y2yUN9inh4VAASUttIh0lJXpuDeZloX5a1O2SJOKBebmpZBqSXF5~Jv6ADNMonLyH6T26XvDua1JIWlxcScB00xQd6kzdrvaXChhV-uCrzWqYR-NM-6ypUKr2MiI-~T5q53kCKwn6IvNHunLSqSiG9veZpo~VCPMfasNzW4tetVhcUWXXYj0uLTI24bsw85KB99CnY7B-QxJBrqmjFFf~ogItKOO2F5Z-k~2cWER8gJvqzmXYW-amLiRtB1BKby2udSDBpLZXcOcEGe7waXJ53mUQhXVsRHROaPG8ubnzA373BARJkZMe4h32o6GOHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834429"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834429/Antibodies_to_vaccine_antigens_in_pooled_polyclonal_human_IgG_products"><img alt="Research paper thumbnail of Antibodies to vaccine antigens in pooled polyclonal human IgG products" class="work-thumbnail" src="https://attachments.academia-assets.com/67253897/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834429/Antibodies_to_vaccine_antigens_in_pooled_polyclonal_human_IgG_products">Antibodies to vaccine antigens in pooled polyclonal human IgG products</a></div><div class="wp-workCard_item"><span>Transfusion</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">* In this table, data from Wu et al. 42 is for products made from US plasma only.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b2890bdaf32e2d0123899e6abc854b9a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253897,"asset_id":48834429,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253897/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834429"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834429"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834429; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834429]").text(description); $(".js-view-count[data-work-id=48834429]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834429; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834429']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b2890bdaf32e2d0123899e6abc854b9a" } } $('.js-work-strip[data-work-id=48834429]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834429,"title":"Antibodies to vaccine antigens in pooled polyclonal human IgG products","internal_url":"https://www.academia.edu/48834429/Antibodies_to_vaccine_antigens_in_pooled_polyclonal_human_IgG_products","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253897,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253897/thumbnails/1.jpg","file_name":"trf.pdf","download_url":"https://www.academia.edu/attachments/67253897/download_file","bulk_download_file_name":"Antibodies_to_vaccine_antigens_in_pooled.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253897/trf-libre.pdf?1620414305=\u0026response-content-disposition=attachment%3B+filename%3DAntibodies_to_vaccine_antigens_in_pooled.pdf\u0026Expires=1739840592\u0026Signature=Oc4bEPUeKCh5rF90YAn2uvF8T-mm5JsoW7MHczHQ43wykpMgIg3WGNO5SupmNmCOYrmjxbgT7iA-vxtCjN348vaTzEbkd4zmi0IarCqcF9qz09OuT3j4pCjhUCDxpKlQ9uUr4VIjDJ3ND2Ecy6ymXddE1EE6x43pjMvoQn6~-ytkhuf-KU89AsceLZ7Ak2Wmmlo16MKJgykvkYSylXyuI-18wpzeMJXqIYF1K1n-ZhM6CgmxrdQOf74-KgFtgjQsJh6hk~B96nzcoEJaVPOja4GZ7WFhnsT88gYQGWMxp25Oc8JLTfI4AlCVUrZXdMXI~Hd8CcAh~yhsj~vbnFSZsg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834428"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834428/_content_IgPro20_the_Polyneuropathy_and_Treatment_with_Hizentra_study_PATH_and_the_treatment_of_chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_subcutaneous_IgG_sup_content_"><img alt="Research paper thumbnail of {"__content__"=>"IgPro20, the Polyneuropathy and Treatment with Hizentra study (PATH), and the treatment of chronic inflammatory demyelinating polyradiculoneuropathy with subcutaneous IgG.", "sup"=>{"__content__"=>"庐"}}" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834428/_content_IgPro20_the_Polyneuropathy_and_Treatment_with_Hizentra_study_PATH_and_the_treatment_of_chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_subcutaneous_IgG_sup_content_">{"__content__"=>"IgPro20, the Polyneuropathy and Treatment with Hizentra study (PATH), and the treatment of chronic inflammatory demyelinating polyradiculoneuropathy with subcutaneous IgG.", "sup"=>{"__content__"=>"庐"}}</a></div><div class="wp-workCard_item"><span>Immunotherapy</span><span>, Jan 16, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Subcutaneous IgG (SCIG) administration may be preferred over the intravenous route (IVIG) in chro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Subcutaneous IgG (SCIG) administration may be preferred over the intravenous route (IVIG) in chronic inflammatory demyelinating polyneuropathy (CIDP) because it minimizes &#39;end of cycle&#39; treatment-related fluctuations, reduces systemic adverse effects, improves convenience/quality of life and potentially lowers overall costs. Early reports of the use of highly concentrated SCIG preparations suggested they were effective and well-tolerated in chronic inflammatory demyelinating polyneuropathy. This was confirmed in the Polyneuropathy and Treatment with Hizentra study of 172 subjects randomized to receive maintenance therapy with placebo or one of two doses of IgPro20 (20% IgG stabilized with L-Proline) for 6聽months. Risk of relapse was reduced by SCIG in a dose-related manner as compared with placebo. A total of 88% of polyneuropathy and treatment with hizentra subjects felt the subcutaneous method was聽&#39;easy to learn&#39;. Local adverse events were mostly mild or moderate, ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834428"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834428"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834428; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834428]").text(description); $(".js-view-count[data-work-id=48834428]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834428; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834428']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834428]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834428,"title":"{\"__content__\"=\u003e\"IgPro20, the Polyneuropathy and Treatment with Hizentra study (PATH), and the treatment of chronic inflammatory demyelinating polyradiculoneuropathy with subcutaneous IgG.\", \"sup\"=\u003e{\"__content__\"=\u003e\"庐\"}}","internal_url":"https://www.academia.edu/48834428/_content_IgPro20_the_Polyneuropathy_and_Treatment_with_Hizentra_study_PATH_and_the_treatment_of_chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_subcutaneous_IgG_sup_content_","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834427"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834427/Individualized_immunoglobulin_therapy_in_chronic_immune_mediated_peripheral_neuropathies"><img alt="Research paper thumbnail of Individualized immunoglobulin therapy in chronic immune-mediated peripheral neuropathies" class="work-thumbnail" src="https://attachments.academia-assets.com/67253895/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834427/Individualized_immunoglobulin_therapy_in_chronic_immune_mediated_peripheral_neuropathies">Individualized immunoglobulin therapy in chronic immune-mediated peripheral neuropathies</a></div><div class="wp-workCard_item"><span>Journal of the peripheral nervous system : JPNS</span><span>, Jan 23, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite the well-recognized importance of immunoglobulin therapy individualization during the tre...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite the well-recognized importance of immunoglobulin therapy individualization during the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP), the pathway to best achieve optimization is unknown. There are many pharmacokinetic and immunobiologic variables that can potentially influence the appropriateness of any individual therapy. Although identification of specific autoantibodies and their targets has only been accomplished in a minority of patients with CIDP, already the diagnostic and treatment implications of specific autoantibody detection are being realized. Individual variability in IgG pharmacokinetic properties including IgG catabolic rates and distribution, as well as the IgG level necessary for disease control also require consideration during the optimization process. For optimization to be successful there must be a measure of treatment response that has a clinically meaningful interpretation. There are currently available well-defined and validat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f58237164d2d9db3dd4b22df54cf9bfc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253895,"asset_id":48834427,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253895/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834427"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834427"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834427; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834427]").text(description); $(".js-view-count[data-work-id=48834427]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834427; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834427']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f58237164d2d9db3dd4b22df54cf9bfc" } } $('.js-work-strip[data-work-id=48834427]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834427,"title":"Individualized immunoglobulin therapy in chronic immune-mediated peripheral neuropathies","internal_url":"https://www.academia.edu/48834427/Individualized_immunoglobulin_therapy_in_chronic_immune_mediated_peripheral_neuropathies","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253895,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253895/thumbnails/1.jpg","file_name":"fullpdf.pdf","download_url":"https://www.academia.edu/attachments/67253895/download_file","bulk_download_file_name":"Individualized_immunoglobulin_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253895/fullpdf-libre.pdf?1620414305=\u0026response-content-disposition=attachment%3B+filename%3DIndividualized_immunoglobulin_therapy_in.pdf\u0026Expires=1739840592\u0026Signature=U2~7WiDYjWHOo7KQGuAm9zJklaPmLIbuEe5n3CMzCr8mNY-KuUOkcMoCl9kgehn-MKuH3syYzx6JF8jEXWBmJyjao~I84dleRrwhjApXfY4yrnbJK5RwKaSc9FriqrSZpFnijgmAZl2UjlakjrFSHLRHQMGzERwuGbZ43lrvwSX6i0q8jkIhpf67ayh2O5yh-~sNol6619yAMbVO9sznZFc1anuiO0KoC5Ds0FhiCJ4xDxq0AZzky7QY8Pzj1ZrSD5WOw6aeHY09NfYyaEyAJjZWZFCYYQOW4s8pswqm0MHj9aezLZcs2nRUh6Suye9n5n7BDURElri-VDYxyozbOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834426"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834426/Primary_immune_deficiency_diseases_as_unrecognized_causes_of_chronic_respiratory_disease"><img alt="Research paper thumbnail of Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease" class="work-thumbnail" src="https://attachments.academia-assets.com/67253894/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834426/Primary_immune_deficiency_diseases_as_unrecognized_causes_of_chronic_respiratory_disease">Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease</a></div><div class="wp-workCard_item"><span>Respiratory medicine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">More than half of all primary immune deficiency diseases (PIDD) affect antibody production and ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">More than half of all primary immune deficiency diseases (PIDD) affect antibody production and are well known as causes of recurrent sinusitis and lung infections. Chronic and recurrent infections of the upper and/or lower airways can contribute to inflammatory and obstructive processes in the lower airways which are initially reversible and considered &quot;asthma&quot;, but can eventually cause irreversible remodeling and chronic obstructive pulmonary disease (COPD). Conversely, several lines of evidence suggest that many patients who present with a diagnosis of asthma have an increased incidence of infection, suggesting underlying host-defense defects. Asthma and respiratory infections in the first decades of life are recognized as risk factors for development of COPD, but when patients present with COPD as adults, underlying primary immune deficiency disease may be unrecognized. Detection of PIDD as a potentially treatable underlying contributor to recurrent/acute exacerbations ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b6241641781cd44bc5510045e4143f98" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253894,"asset_id":48834426,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253894/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834426"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834426"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834426; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834426]").text(description); $(".js-view-count[data-work-id=48834426]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834426; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834426']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b6241641781cd44bc5510045e4143f98" } } $('.js-work-strip[data-work-id=48834426]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834426,"title":"Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease","internal_url":"https://www.academia.edu/48834426/Primary_immune_deficiency_diseases_as_unrecognized_causes_of_chronic_respiratory_disease","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253894,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253894/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/67253894/download_file","bulk_download_file_name":"Primary_immune_deficiency_diseases_as_un.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253894/pdf-libre.pdf?1620414305=\u0026response-content-disposition=attachment%3B+filename%3DPrimary_immune_deficiency_diseases_as_un.pdf\u0026Expires=1739840592\u0026Signature=drRe-AHLUoDFzbTFB5MTUX3CKa2Orc9cz0UeGywYNLIVmF6~owDSw3Le8sF3LNt3ub6l2lGJcWBxT7z4OhRrMstKQ0tLoXhNx5qKNHEaTLesnotDjH6j0Lcn3Pt4paNGH8RgaxzIrit4avnxCPn0xSbJpwxoGiHgLKJZhLJPIJAxneRfwZSI1MXOUmwDOywA8c1Dy~5cwVpO1ogUwbgSGK9J-AAIa2YhQ6awhlgV6fS2cqecj0B4eF9heCRS7OfMDCcMOPwuFNIoLgfSvOoPEn6-xkCH5Fd1smjjDSrmXCCVzP9qstx37MnEqRbD6SkJeYLuCHcXhKr2K6S3QCcKCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834425"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834425/Immunoglobulin_therapy_in_hematologic_neoplasms_and_after_hematopoietic_cell_transplantation"><img alt="Research paper thumbnail of Immunoglobulin therapy in hematologic neoplasms and after hematopoietic cell transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834425/Immunoglobulin_therapy_in_hematologic_neoplasms_and_after_hematopoietic_cell_transplantation">Immunoglobulin therapy in hematologic neoplasms and after hematopoietic cell transplantation</a></div><div class="wp-workCard_item"><span>Blood Reviews</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Immunoglobulins are used to prevent or reduce infection risk in primary immune deficiencies and i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Immunoglobulins are used to prevent or reduce infection risk in primary immune deficiencies and in settings which exploit its anti-inflammatory and immune-modulatory effects. Rigorous proof of immunoglobulin efficacy in persons with lympho-proliferative neoplasms, plasma cell myeloma, and persons receiving hematopoietic cell transplants is lacking despite many clinical trials. Further, there are few consensus guidelines or algorithms for use in these conditions. Rapid development of new therapies targeting B-cell signaling and survival pathways and increased use of chimeric antigen receptor T-cell (CAR-T) therapy will likely result in more acquired deficiencies of humoral immunity and infections in persons with cancer. We review immunoglobulin formulations and discuss efficacy and potential adverse effects in the context of preventing infections and in graft-versus-host disease. We suggest an algorithm for evaluating acquired deficiencies of humoral immunity in persons with hematologic neoplasms and recommend appropriate use of immunoglobulin therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834425"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834425"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834425; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834425]").text(description); $(".js-view-count[data-work-id=48834425]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834425; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834425']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834425]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834425,"title":"Immunoglobulin therapy in hematologic neoplasms and after hematopoietic cell transplantation","internal_url":"https://www.academia.edu/48834425/Immunoglobulin_therapy_in_hematologic_neoplasms_and_after_hematopoietic_cell_transplantation","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834424"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834424/Lung_inflammation_early_in_cystic_fibrosis_bugs_are_indicted_but_the_defense_is_guilty"><img alt="Research paper thumbnail of Lung inflammation early in cystic fibrosis: bugs are indicted, but the defense is guilty" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834424/Lung_inflammation_early_in_cystic_fibrosis_bugs_are_indicted_but_the_defense_is_guilty">Lung inflammation early in cystic fibrosis: bugs are indicted, but the defense is guilty</a></div><div class="wp-workCard_item"><span>American Journal of Respiratory and Critical Care Medicine</span><span>, May 1, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834424"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834424"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834424; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834424]").text(description); $(".js-view-count[data-work-id=48834424]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834424; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834424']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834424]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834424,"title":"Lung inflammation early in cystic fibrosis: bugs are indicted, but the defense is guilty","internal_url":"https://www.academia.edu/48834424/Lung_inflammation_early_in_cystic_fibrosis_bugs_are_indicted_but_the_defense_is_guilty","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834423"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834423/Parthenolide_inhibits_I%CE%BAB_kinase_NF_KB_activation_and_inflammatory_response_in_cystic_fibrosis_cells_and_mice"><img alt="Research paper thumbnail of Parthenolide inhibits I魏B kinase, NF-KB activation, and inflammatory response in cystic fibrosis cells and mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834423/Parthenolide_inhibits_I%CE%BAB_kinase_NF_KB_activation_and_inflammatory_response_in_cystic_fibrosis_cells_and_mice">Parthenolide inhibits I魏B kinase, NF-KB activation, and inflammatory response in cystic fibrosis cells and mice</a></div><div class="wp-workCard_item"><span>American Journal of Respiratory Cell and Molecular Biology</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834423"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834423"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834423; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834423]").text(description); $(".js-view-count[data-work-id=48834423]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834423; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834423']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834423]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834423,"title":"Parthenolide inhibits I魏B kinase, NF-KB activation, and inflammatory response in cystic fibrosis cells and mice","internal_url":"https://www.academia.edu/48834423/Parthenolide_inhibits_I%CE%BAB_kinase_NF_KB_activation_and_inflammatory_response_in_cystic_fibrosis_cells_and_mice","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834422"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834422/Assessment_of_protein_antibody_response_in_patients_with_suspected_immune_deficiency"><img alt="Research paper thumbnail of Assessment of protein antibody response in patients with suspected immune deficiency" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834422/Assessment_of_protein_antibody_response_in_patients_with_suspected_immune_deficiency">Assessment of protein antibody response in patients with suspected immune deficiency</a></div><div class="wp-workCard_item"><span>Annals of Allergy Asthma Immunology Official Publication of the American College of Allergy Asthma Immunology</span><span>, Mar 1, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834422"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834422"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834422; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834422]").text(description); $(".js-view-count[data-work-id=48834422]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834422; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834422']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834422]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834422,"title":"Assessment of protein antibody response in patients with suspected immune deficiency","internal_url":"https://www.academia.edu/48834422/Assessment_of_protein_antibody_response_in_patients_with_suspected_immune_deficiency","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834421"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834421/Inflammation_in_the_lung_in_cystic_fibrosis"><img alt="Research paper thumbnail of Inflammation in the lung in cystic fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/67253891/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834421/Inflammation_in_the_lung_in_cystic_fibrosis">Inflammation in the lung in cystic fibrosis</a></div><div class="wp-workCard_item"><span>Clin Rev Allergy Immunol</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although the relationship between the basic cellular defect in Cystic Fibrosis (CF) and the facto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although the relationship between the basic cellular defect in Cystic Fibrosis (CF) and the factors that predispose the CF patient to colonization with Pseudornonas aeruginosa remain undefined, it</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd021308009ac6fb25255954c8df379b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253891,"asset_id":48834421,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253891/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834421"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834421"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834421; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834421]").text(description); $(".js-view-count[data-work-id=48834421]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834421; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834421']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fd021308009ac6fb25255954c8df379b" } } $('.js-work-strip[data-work-id=48834421]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834421,"title":"Inflammation in the lung in cystic fibrosis","internal_url":"https://www.academia.edu/48834421/Inflammation_in_the_lung_in_cystic_fibrosis","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253891,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253891/thumbnails/1.jpg","file_name":"bf0291453820210507-5929-1uyx90f.pdf","download_url":"https://www.academia.edu/attachments/67253891/download_file","bulk_download_file_name":"Inflammation_in_the_lung_in_cystic_fibro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253891/bf0291453820210507-5929-1uyx90f-libre.pdf?1620414310=\u0026response-content-disposition=attachment%3B+filename%3DInflammation_in_the_lung_in_cystic_fibro.pdf\u0026Expires=1739840592\u0026Signature=B~KeaJO~1lbXTLiYfQ4P4gOlFLV7gwG~bK6tplEVFhm-GsGlWqy09GZsgoqY-87oimwISRgS00O8Js6He6ubF5PgP-ZSzA5a4XnmfzWUG2hMwvLjLpoGimrBx2sCQmduVBcdWR9EeAYiNufD5Sq16urHc0It4JHYAD0Q-wsYLkiloR92y4oMcRg9Gvzc5JD1tgCOGrH3bpDgyKAIxObZKt571-twvS3PLVghWWn8W0ST2AOjGH9~JWC3hj8a44acyPaRM2od0towIa3e6pXKGSKxjTg6oQvFHeOUkCNLLhOyip0JMRCamRFr2ZVI90W8xOmE4bAY3kyjHWE27RmR4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834420"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834420/Intravenous_%CE%B3_globulin_therapy_in_bronchial_asthma"><img alt="Research paper thumbnail of Intravenous 纬-globulin therapy in bronchial asthma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834420/Intravenous_%CE%B3_globulin_therapy_in_bronchial_asthma">Intravenous 纬-globulin therapy in bronchial asthma</a></div><div class="wp-workCard_item"><span>Allergy and Asthma Proceedings</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834420"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834420"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834420; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834420]").text(description); $(".js-view-count[data-work-id=48834420]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834420; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834420']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834420]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834420,"title":"Intravenous 纬-globulin therapy in bronchial asthma","internal_url":"https://www.academia.edu/48834420/Intravenous_%CE%B3_globulin_therapy_in_bronchial_asthma","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834419"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834419/Allergic_bronchopulmonary_aspergillosis_and_common_variable_hypogammaglobulinemia_in_an_adult_male_patient_Case_report"><img alt="Research paper thumbnail of Allergic bronchopulmonary aspergillosis and common variable hypogammaglobulinemia in an adult male patient: Case report" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834419/Allergic_bronchopulmonary_aspergillosis_and_common_variable_hypogammaglobulinemia_in_an_adult_male_patient_Case_report">Allergic bronchopulmonary aspergillosis and common variable hypogammaglobulinemia in an adult male patient: Case report</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 1996</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834419"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834419"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834419; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834419]").text(description); $(".js-view-count[data-work-id=48834419]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834419; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834419']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834419]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834419,"title":"Allergic bronchopulmonary aspergillosis and common variable hypogammaglobulinemia in an adult male patient: Case report","internal_url":"https://www.academia.edu/48834419/Allergic_bronchopulmonary_aspergillosis_and_common_variable_hypogammaglobulinemia_in_an_adult_male_patient_Case_report","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834418"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834418/Subcutaneous_Immunoglobulin_Replacement_Therapy_in_Infants_and_Children_with_Primary_Immunodeficiencies"><img alt="Research paper thumbnail of Subcutaneous Immunoglobulin Replacement Therapy in Infants and Children with Primary Immunodeficiencies" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834418/Subcutaneous_Immunoglobulin_Replacement_Therapy_in_Infants_and_Children_with_Primary_Immunodeficiencies">Subcutaneous Immunoglobulin Replacement Therapy in Infants and Children with Primary Immunodeficiencies</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, Feb 1, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834418"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834418"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834418; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834418]").text(description); $(".js-view-count[data-work-id=48834418]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834418; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834418']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834418]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834418,"title":"Subcutaneous Immunoglobulin Replacement Therapy in Infants and Children with Primary Immunodeficiencies","internal_url":"https://www.academia.edu/48834418/Subcutaneous_Immunoglobulin_Replacement_Therapy_in_Infants_and_Children_with_Primary_Immunodeficiencies","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834417"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834417/Immunoglobulins_in_the_newborn"><img alt="Research paper thumbnail of Immunoglobulins in the newborn" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834417/Immunoglobulins_in_the_newborn">Immunoglobulins in the newborn</a></div><div class="wp-workCard_item"><span>Curr Opin Infect Dis</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834417"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834417"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834417; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834417]").text(description); $(".js-view-count[data-work-id=48834417]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834417; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834417']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834417]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834417,"title":"Immunoglobulins in the newborn","internal_url":"https://www.academia.edu/48834417/Immunoglobulins_in_the_newborn","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834416"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834416/Management_of_PrimaryAntibody_Deficiency_with_Replacement_Therapy_Summary_of_Guidelines"><img alt="Research paper thumbnail of Management of PrimaryAntibody Deficiency with Replacement Therapy : Summary of Guidelines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834416/Management_of_PrimaryAntibody_Deficiency_with_Replacement_Therapy_Summary_of_Guidelines">Management of PrimaryAntibody Deficiency with Replacement Therapy : Summary of Guidelines</a></div><div class="wp-workCard_item"><span>Immunology and Allergy Clinics of North America</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This article summarizes the guidelines for using replacement therapy in the management of patient...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This article summarizes the guidelines for using replacement therapy in the management of patients who have primary antibody deficiency.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834416"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834416"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834416; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834416]").text(description); $(".js-view-count[data-work-id=48834416]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834416; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834416']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834416]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834416,"title":"Management of PrimaryAntibody Deficiency with Replacement Therapy : Summary of Guidelines","internal_url":"https://www.academia.edu/48834416/Management_of_PrimaryAntibody_Deficiency_with_Replacement_Therapy_Summary_of_Guidelines","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834415"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834415/Circulating_Immune_Complexes_and_Glomerulonephritis_in_a_Patient_with_Congenital_Absence_of_the_Third_Component_of_Complement"><img alt="Research paper thumbnail of Circulating Immune Complexes and Glomerulonephritis in a Patient with Congenital Absence of the Third Component of Complement" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834415/Circulating_Immune_Complexes_and_Glomerulonephritis_in_a_Patient_with_Congenital_Absence_of_the_Third_Component_of_Complement">Circulating Immune Complexes and Glomerulonephritis in a Patient with Congenital Absence of the Third Component of Complement</a></div><div class="wp-workCard_item"><span>N Engl J Med</span><span>, 1983</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... ABSENCE OF THE THIRD COMPONENT OF COMPLEMENT Melvin Berger, MD, Ph.D., James E. Balow, MD, Cu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... ABSENCE OF THE THIRD COMPONENT OF COMPLEMENT Melvin Berger, MD, Ph.D., James E. Balow, MD, Curtis B. Wilson, MD, and Michael M. Frank, MD THE third component of complement (C3) is criti-cally involved in host defense and the mainte-nance of normal ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834415"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834415"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834415; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834415]").text(description); $(".js-view-count[data-work-id=48834415]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834415; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834415']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834415]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834415,"title":"Circulating Immune Complexes and Glomerulonephritis in a Patient with Congenital Absence of the Third Component of Complement","internal_url":"https://www.academia.edu/48834415/Circulating_Immune_Complexes_and_Glomerulonephritis_in_a_Patient_with_Congenital_Absence_of_the_Third_Component_of_Complement","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834414"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834414/_74_Third_component_of_human_complement_C3"><img alt="Research paper thumbnail of [74] Third component of human complement: C3" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834414/_74_Third_component_of_human_complement_C3">[74] Third component of human complement: C3</a></div><div class="wp-workCard_item"><span>Methods in Enzymology</span><span>, 1990</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834414"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834414"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834414; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834414]").text(description); $(".js-view-count[data-work-id=48834414]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834414; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834414']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834414]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834414,"title":"[74] Third component of human complement: C3","internal_url":"https://www.academia.edu/48834414/_74_Third_component_of_human_complement_C3","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834413"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834413/Normal_bronchial_epithelial_cells_produce_the_anti_inflammatory_cytokine_IL_10_which_is_downregulated_in_CF_while_IL_8_is_upregulated"><img alt="Research paper thumbnail of Normal bronchial epithelial cells produce the anti-inflammatory cytokine IL-10, which is downregulated in CF, while IL-8 is upregulated" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834413/Normal_bronchial_epithelial_cells_produce_the_anti_inflammatory_cytokine_IL_10_which_is_downregulated_in_CF_while_IL_8_is_upregulated">Normal bronchial epithelial cells produce the anti-inflammatory cytokine IL-10, which is downregulated in CF, while IL-8 is upregulated</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834413"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834413"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834413; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834413]").text(description); $(".js-view-count[data-work-id=48834413]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834413; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834413']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834413]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834413,"title":"Normal bronchial epithelial cells produce the anti-inflammatory cytokine IL-10, which is downregulated in CF, while IL-8 is upregulated","internal_url":"https://www.academia.edu/48834413/Normal_bronchial_epithelial_cells_produce_the_anti_inflammatory_cytokine_IL_10_which_is_downregulated_in_CF_while_IL_8_is_upregulated","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4121119" id="papers"><div class="js-work-strip profile--work_container" data-work-id="48834432"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834432/Isolation_and_Characterization_of_Complement_Receptor_Type_1_CR1_Storage_Vesicles_From_Human_Neutrophils_Using_Antibodies_to_the_Cytoplasmic_Tail_of_CR1"><img alt="Research paper thumbnail of Isolation and Characterization of Complement Receptor Type 1 (CR1) Storage Vesicles From Human Neutrophils Using Antibodies to the Cytoplasmic Tail of CR1" class="work-thumbnail" src="https://attachments.academia-assets.com/67253852/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834432/Isolation_and_Characterization_of_Complement_Receptor_Type_1_CR1_Storage_Vesicles_From_Human_Neutrophils_Using_Antibodies_to_the_Cytoplasmic_Tail_of_CR1">Isolation and Characterization of Complement Receptor Type 1 (CR1) Storage Vesicles From Human Neutrophils Using Antibodies to the Cytoplasmic Tail of CR1</a></div><div class="wp-workCard_item"><span>Blood</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Neutrophil (PMN) activation is associated with increased surface expression of several membrane p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Neutrophil (PMN) activation is associated with increased surface expression of several membrane proteins that are translocated from intracellular pools. Indirect evidence suggests that the intracellular storage pools of complement receptor type 1 (CR1) in resting PMN are distinct from traditional granules and may be the secretory vesicles in which albumin is also stored, but it is not known if this compartment is homogeneous or heterogeneous. To isolate and characterize the CR1-containing vesicles, we used antibodies against unique sequences in the cytoplasmic tail of CR1. Affinity-purified IgG was used to adsorb CR1 storage vesicles from the light membrane fraction (纬-band) of nitrogen cavitates of resting PMN. The immunoadsorbent could quantitatively remove the CR1-containing vesicles, whereas control adsorbents with nonimmune IgG showed no specific binding of CR1. Immunoblots of specifically isolated vesicles also showed enrichment of albumin, decay-accelerating factor, Fc纬RIII, ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f4618ea5165916ed4adac9f40e156c4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253852,"asset_id":48834432,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253852/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834432"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834432"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834432; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834432]").text(description); $(".js-view-count[data-work-id=48834432]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834432; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834432']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f4618ea5165916ed4adac9f40e156c4d" } } $('.js-work-strip[data-work-id=48834432]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834432,"title":"Isolation and Characterization of Complement Receptor Type 1 (CR1) Storage Vesicles From Human Neutrophils Using Antibodies to the Cytoplasmic Tail of CR1","internal_url":"https://www.academia.edu/48834432/Isolation_and_Characterization_of_Complement_Receptor_Type_1_CR1_Storage_Vesicles_From_Human_Neutrophils_Using_Antibodies_to_the_Cytoplasmic_Tail_of_CR1","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253852,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253852/thumbnails/1.jpg","file_name":"4555.pdf","download_url":"https://www.academia.edu/attachments/67253852/download_file","bulk_download_file_name":"Isolation_and_Characterization_of_Comple.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253852/4555-libre.pdf?1620414306=\u0026response-content-disposition=attachment%3B+filename%3DIsolation_and_Characterization_of_Comple.pdf\u0026Expires=1739840592\u0026Signature=MRExkrsvi3O0bGWBREdtT6BRYjg5P2~5io75JMifoQ8zqekXWnNLgL1LYRF-4hs-esH3uFbrPFCO4Mv~m80I~oljPS-5DkTrimnzjAk30sE1BQklK0TQpbdfJ63qpqom4pDJnArbBaNUg75qcop5BCCKvqe-2nA17lQKZ3FuD7NZp2p2Thrg45lMmNOiIp2jANYpGCIOUqdm56HWh~9hz38ZS42W5F0v4pV2eelgXyaIfTDnWrnVJiXQ9blF1eO7pe~1jpj~15KvVMzDSUEoYKAh86XGW12GhxWnNHeuG606MCgeNwGoC40by~qIWRlurQVqBe3m6iq0YT85bZ1YVg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834431"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834431/Update_on_C1_Esterase_Inhibitor_C1_INH_in_Human_Solid_Organ_Transplantation"><img alt="Research paper thumbnail of Update on C1 Esterase Inhibitor (C1-INH) in Human Solid Organ Transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834431/Update_on_C1_Esterase_Inhibitor_C1_INH_in_Human_Solid_Organ_Transplantation">Update on C1 Esterase Inhibitor (C1-INH) in Human Solid Organ Transplantation</a></div><div class="wp-workCard_item"><span>Transplantation</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834431"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834431"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834431; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834431]").text(description); $(".js-view-count[data-work-id=48834431]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834431; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834431']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834431]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834431,"title":"Update on C1 Esterase Inhibitor (C1-INH) in Human Solid Organ Transplantation","internal_url":"https://www.academia.edu/48834431/Update_on_C1_Esterase_Inhibitor_C1_INH_in_Human_Solid_Organ_Transplantation","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834430"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834430/Alpha_1_antitrypsin_in_cell_and_organ_transplantation"><img alt="Research paper thumbnail of Alpha-1-antitrypsin in cell and organ transplantation" class="work-thumbnail" src="https://attachments.academia-assets.com/67253893/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834430/Alpha_1_antitrypsin_in_cell_and_organ_transplantation">Alpha-1-antitrypsin in cell and organ transplantation</a></div><div class="wp-workCard_item"><span>American Journal of Transplantation</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite significant advances in surgical technique and immunosuppression, challenges continue to ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite significant advances in surgical technique and immunosuppression, challenges continue to restrict the number of transplants. Although the number of transplants performed each year in the United States is increasing, the number of people on waiting lists has nearly doubled in the past 15 years. 1 Improving the viability of donor organs by reducing the damage caused by ischemia-reperfusion injury (IRI) and activation of the innate immune system are thus key areas of ongoing research. Alpha-1-antitrypsin (AAT) is a serine protease inhibitor and acute phase reactant produced mainly by the liver that limits tissue damage caused by neutrophil elastase and other extracellular enzymes. 2-4 Consistent with this role, plasma concentrations of AAT can increase up to 4-fold in response to inflammatory stimuli. Mutations in AAT can cause emphysema due to deficiency in circulating AAT, and/or liver disease likely due to a "misfolded protein response." 2-4 AAT-deficient patients may also experience extrapulmonary pathologies, particularly panniculitis</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa7859e322f4593e08a5b5184be77ea9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253893,"asset_id":48834430,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253893/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834430"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834430"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834430; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834430]").text(description); $(".js-view-count[data-work-id=48834430]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834430; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834430']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa7859e322f4593e08a5b5184be77ea9" } } $('.js-work-strip[data-work-id=48834430]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834430,"title":"Alpha-1-antitrypsin in cell and organ transplantation","internal_url":"https://www.academia.edu/48834430/Alpha_1_antitrypsin_in_cell_and_organ_transplantation","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253893,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253893/thumbnails/1.jpg","file_name":"fullpdf.pdf","download_url":"https://www.academia.edu/attachments/67253893/download_file","bulk_download_file_name":"Alpha_1_antitrypsin_in_cell_and_organ_tr.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253893/fullpdf-libre.pdf?1620414308=\u0026response-content-disposition=attachment%3B+filename%3DAlpha_1_antitrypsin_in_cell_and_organ_tr.pdf\u0026Expires=1739840592\u0026Signature=LR45YnIXD-5h0Xq9FJiJ3r7Y2yUN9inh4VAASUttIh0lJXpuDeZloX5a1O2SJOKBebmpZBqSXF5~Jv6ADNMonLyH6T26XvDua1JIWlxcScB00xQd6kzdrvaXChhV-uCrzWqYR-NM-6ypUKr2MiI-~T5q53kCKwn6IvNHunLSqSiG9veZpo~VCPMfasNzW4tetVhcUWXXYj0uLTI24bsw85KB99CnY7B-QxJBrqmjFFf~ogItKOO2F5Z-k~2cWER8gJvqzmXYW-amLiRtB1BKby2udSDBpLZXcOcEGe7waXJ53mUQhXVsRHROaPG8ubnzA373BARJkZMe4h32o6GOHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834429"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834429/Antibodies_to_vaccine_antigens_in_pooled_polyclonal_human_IgG_products"><img alt="Research paper thumbnail of Antibodies to vaccine antigens in pooled polyclonal human IgG products" class="work-thumbnail" src="https://attachments.academia-assets.com/67253897/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834429/Antibodies_to_vaccine_antigens_in_pooled_polyclonal_human_IgG_products">Antibodies to vaccine antigens in pooled polyclonal human IgG products</a></div><div class="wp-workCard_item"><span>Transfusion</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">* In this table, data from Wu et al. 42 is for products made from US plasma only.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b2890bdaf32e2d0123899e6abc854b9a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253897,"asset_id":48834429,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253897/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834429"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834429"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834429; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834429]").text(description); $(".js-view-count[data-work-id=48834429]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834429; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834429']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b2890bdaf32e2d0123899e6abc854b9a" } } $('.js-work-strip[data-work-id=48834429]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834429,"title":"Antibodies to vaccine antigens in pooled polyclonal human IgG products","internal_url":"https://www.academia.edu/48834429/Antibodies_to_vaccine_antigens_in_pooled_polyclonal_human_IgG_products","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253897,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253897/thumbnails/1.jpg","file_name":"trf.pdf","download_url":"https://www.academia.edu/attachments/67253897/download_file","bulk_download_file_name":"Antibodies_to_vaccine_antigens_in_pooled.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253897/trf-libre.pdf?1620414305=\u0026response-content-disposition=attachment%3B+filename%3DAntibodies_to_vaccine_antigens_in_pooled.pdf\u0026Expires=1739840592\u0026Signature=Oc4bEPUeKCh5rF90YAn2uvF8T-mm5JsoW7MHczHQ43wykpMgIg3WGNO5SupmNmCOYrmjxbgT7iA-vxtCjN348vaTzEbkd4zmi0IarCqcF9qz09OuT3j4pCjhUCDxpKlQ9uUr4VIjDJ3ND2Ecy6ymXddE1EE6x43pjMvoQn6~-ytkhuf-KU89AsceLZ7Ak2Wmmlo16MKJgykvkYSylXyuI-18wpzeMJXqIYF1K1n-ZhM6CgmxrdQOf74-KgFtgjQsJh6hk~B96nzcoEJaVPOja4GZ7WFhnsT88gYQGWMxp25Oc8JLTfI4AlCVUrZXdMXI~Hd8CcAh~yhsj~vbnFSZsg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834428"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834428/_content_IgPro20_the_Polyneuropathy_and_Treatment_with_Hizentra_study_PATH_and_the_treatment_of_chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_subcutaneous_IgG_sup_content_"><img alt="Research paper thumbnail of {"__content__"=>"IgPro20, the Polyneuropathy and Treatment with Hizentra study (PATH), and the treatment of chronic inflammatory demyelinating polyradiculoneuropathy with subcutaneous IgG.", "sup"=>{"__content__"=>"庐"}}" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834428/_content_IgPro20_the_Polyneuropathy_and_Treatment_with_Hizentra_study_PATH_and_the_treatment_of_chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_subcutaneous_IgG_sup_content_">{"__content__"=>"IgPro20, the Polyneuropathy and Treatment with Hizentra study (PATH), and the treatment of chronic inflammatory demyelinating polyradiculoneuropathy with subcutaneous IgG.", "sup"=>{"__content__"=>"庐"}}</a></div><div class="wp-workCard_item"><span>Immunotherapy</span><span>, Jan 16, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Subcutaneous IgG (SCIG) administration may be preferred over the intravenous route (IVIG) in chro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Subcutaneous IgG (SCIG) administration may be preferred over the intravenous route (IVIG) in chronic inflammatory demyelinating polyneuropathy (CIDP) because it minimizes &#39;end of cycle&#39; treatment-related fluctuations, reduces systemic adverse effects, improves convenience/quality of life and potentially lowers overall costs. Early reports of the use of highly concentrated SCIG preparations suggested they were effective and well-tolerated in chronic inflammatory demyelinating polyneuropathy. This was confirmed in the Polyneuropathy and Treatment with Hizentra study of 172 subjects randomized to receive maintenance therapy with placebo or one of two doses of IgPro20 (20% IgG stabilized with L-Proline) for 6聽months. Risk of relapse was reduced by SCIG in a dose-related manner as compared with placebo. A total of 88% of polyneuropathy and treatment with hizentra subjects felt the subcutaneous method was聽&#39;easy to learn&#39;. Local adverse events were mostly mild or moderate, ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834428"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834428"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834428; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834428]").text(description); $(".js-view-count[data-work-id=48834428]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834428; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834428']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834428]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834428,"title":"{\"__content__\"=\u003e\"IgPro20, the Polyneuropathy and Treatment with Hizentra study (PATH), and the treatment of chronic inflammatory demyelinating polyradiculoneuropathy with subcutaneous IgG.\", \"sup\"=\u003e{\"__content__\"=\u003e\"庐\"}}","internal_url":"https://www.academia.edu/48834428/_content_IgPro20_the_Polyneuropathy_and_Treatment_with_Hizentra_study_PATH_and_the_treatment_of_chronic_inflammatory_demyelinating_polyradiculoneuropathy_with_subcutaneous_IgG_sup_content_","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834427"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834427/Individualized_immunoglobulin_therapy_in_chronic_immune_mediated_peripheral_neuropathies"><img alt="Research paper thumbnail of Individualized immunoglobulin therapy in chronic immune-mediated peripheral neuropathies" class="work-thumbnail" src="https://attachments.academia-assets.com/67253895/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834427/Individualized_immunoglobulin_therapy_in_chronic_immune_mediated_peripheral_neuropathies">Individualized immunoglobulin therapy in chronic immune-mediated peripheral neuropathies</a></div><div class="wp-workCard_item"><span>Journal of the peripheral nervous system : JPNS</span><span>, Jan 23, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Despite the well-recognized importance of immunoglobulin therapy individualization during the tre...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Despite the well-recognized importance of immunoglobulin therapy individualization during the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP), the pathway to best achieve optimization is unknown. There are many pharmacokinetic and immunobiologic variables that can potentially influence the appropriateness of any individual therapy. Although identification of specific autoantibodies and their targets has only been accomplished in a minority of patients with CIDP, already the diagnostic and treatment implications of specific autoantibody detection are being realized. Individual variability in IgG pharmacokinetic properties including IgG catabolic rates and distribution, as well as the IgG level necessary for disease control also require consideration during the optimization process. For optimization to be successful there must be a measure of treatment response that has a clinically meaningful interpretation. There are currently available well-defined and validat...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f58237164d2d9db3dd4b22df54cf9bfc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253895,"asset_id":48834427,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253895/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834427"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834427"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834427; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834427]").text(description); $(".js-view-count[data-work-id=48834427]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834427; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834427']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f58237164d2d9db3dd4b22df54cf9bfc" } } $('.js-work-strip[data-work-id=48834427]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834427,"title":"Individualized immunoglobulin therapy in chronic immune-mediated peripheral neuropathies","internal_url":"https://www.academia.edu/48834427/Individualized_immunoglobulin_therapy_in_chronic_immune_mediated_peripheral_neuropathies","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253895,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253895/thumbnails/1.jpg","file_name":"fullpdf.pdf","download_url":"https://www.academia.edu/attachments/67253895/download_file","bulk_download_file_name":"Individualized_immunoglobulin_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253895/fullpdf-libre.pdf?1620414305=\u0026response-content-disposition=attachment%3B+filename%3DIndividualized_immunoglobulin_therapy_in.pdf\u0026Expires=1739840592\u0026Signature=U2~7WiDYjWHOo7KQGuAm9zJklaPmLIbuEe5n3CMzCr8mNY-KuUOkcMoCl9kgehn-MKuH3syYzx6JF8jEXWBmJyjao~I84dleRrwhjApXfY4yrnbJK5RwKaSc9FriqrSZpFnijgmAZl2UjlakjrFSHLRHQMGzERwuGbZ43lrvwSX6i0q8jkIhpf67ayh2O5yh-~sNol6619yAMbVO9sznZFc1anuiO0KoC5Ds0FhiCJ4xDxq0AZzky7QY8Pzj1ZrSD5WOw6aeHY09NfYyaEyAJjZWZFCYYQOW4s8pswqm0MHj9aezLZcs2nRUh6Suye9n5n7BDURElri-VDYxyozbOQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834426"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834426/Primary_immune_deficiency_diseases_as_unrecognized_causes_of_chronic_respiratory_disease"><img alt="Research paper thumbnail of Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease" class="work-thumbnail" src="https://attachments.academia-assets.com/67253894/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834426/Primary_immune_deficiency_diseases_as_unrecognized_causes_of_chronic_respiratory_disease">Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease</a></div><div class="wp-workCard_item"><span>Respiratory medicine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">More than half of all primary immune deficiency diseases (PIDD) affect antibody production and ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">More than half of all primary immune deficiency diseases (PIDD) affect antibody production and are well known as causes of recurrent sinusitis and lung infections. Chronic and recurrent infections of the upper and/or lower airways can contribute to inflammatory and obstructive processes in the lower airways which are initially reversible and considered &quot;asthma&quot;, but can eventually cause irreversible remodeling and chronic obstructive pulmonary disease (COPD). Conversely, several lines of evidence suggest that many patients who present with a diagnosis of asthma have an increased incidence of infection, suggesting underlying host-defense defects. Asthma and respiratory infections in the first decades of life are recognized as risk factors for development of COPD, but when patients present with COPD as adults, underlying primary immune deficiency disease may be unrecognized. Detection of PIDD as a potentially treatable underlying contributor to recurrent/acute exacerbations ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b6241641781cd44bc5510045e4143f98" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253894,"asset_id":48834426,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253894/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834426"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834426"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834426; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834426]").text(description); $(".js-view-count[data-work-id=48834426]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834426; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834426']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b6241641781cd44bc5510045e4143f98" } } $('.js-work-strip[data-work-id=48834426]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834426,"title":"Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease","internal_url":"https://www.academia.edu/48834426/Primary_immune_deficiency_diseases_as_unrecognized_causes_of_chronic_respiratory_disease","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253894,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253894/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/67253894/download_file","bulk_download_file_name":"Primary_immune_deficiency_diseases_as_un.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253894/pdf-libre.pdf?1620414305=\u0026response-content-disposition=attachment%3B+filename%3DPrimary_immune_deficiency_diseases_as_un.pdf\u0026Expires=1739840592\u0026Signature=drRe-AHLUoDFzbTFB5MTUX3CKa2Orc9cz0UeGywYNLIVmF6~owDSw3Le8sF3LNt3ub6l2lGJcWBxT7z4OhRrMstKQ0tLoXhNx5qKNHEaTLesnotDjH6j0Lcn3Pt4paNGH8RgaxzIrit4avnxCPn0xSbJpwxoGiHgLKJZhLJPIJAxneRfwZSI1MXOUmwDOywA8c1Dy~5cwVpO1ogUwbgSGK9J-AAIa2YhQ6awhlgV6fS2cqecj0B4eF9heCRS7OfMDCcMOPwuFNIoLgfSvOoPEn6-xkCH5Fd1smjjDSrmXCCVzP9qstx37MnEqRbD6SkJeYLuCHcXhKr2K6S3QCcKCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834425"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834425/Immunoglobulin_therapy_in_hematologic_neoplasms_and_after_hematopoietic_cell_transplantation"><img alt="Research paper thumbnail of Immunoglobulin therapy in hematologic neoplasms and after hematopoietic cell transplantation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834425/Immunoglobulin_therapy_in_hematologic_neoplasms_and_after_hematopoietic_cell_transplantation">Immunoglobulin therapy in hematologic neoplasms and after hematopoietic cell transplantation</a></div><div class="wp-workCard_item"><span>Blood Reviews</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Immunoglobulins are used to prevent or reduce infection risk in primary immune deficiencies and i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Immunoglobulins are used to prevent or reduce infection risk in primary immune deficiencies and in settings which exploit its anti-inflammatory and immune-modulatory effects. Rigorous proof of immunoglobulin efficacy in persons with lympho-proliferative neoplasms, plasma cell myeloma, and persons receiving hematopoietic cell transplants is lacking despite many clinical trials. Further, there are few consensus guidelines or algorithms for use in these conditions. Rapid development of new therapies targeting B-cell signaling and survival pathways and increased use of chimeric antigen receptor T-cell (CAR-T) therapy will likely result in more acquired deficiencies of humoral immunity and infections in persons with cancer. We review immunoglobulin formulations and discuss efficacy and potential adverse effects in the context of preventing infections and in graft-versus-host disease. We suggest an algorithm for evaluating acquired deficiencies of humoral immunity in persons with hematologic neoplasms and recommend appropriate use of immunoglobulin therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834425"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834425"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834425; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834425]").text(description); $(".js-view-count[data-work-id=48834425]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834425; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834425']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834425]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834425,"title":"Immunoglobulin therapy in hematologic neoplasms and after hematopoietic cell transplantation","internal_url":"https://www.academia.edu/48834425/Immunoglobulin_therapy_in_hematologic_neoplasms_and_after_hematopoietic_cell_transplantation","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834424"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834424/Lung_inflammation_early_in_cystic_fibrosis_bugs_are_indicted_but_the_defense_is_guilty"><img alt="Research paper thumbnail of Lung inflammation early in cystic fibrosis: bugs are indicted, but the defense is guilty" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834424/Lung_inflammation_early_in_cystic_fibrosis_bugs_are_indicted_but_the_defense_is_guilty">Lung inflammation early in cystic fibrosis: bugs are indicted, but the defense is guilty</a></div><div class="wp-workCard_item"><span>American Journal of Respiratory and Critical Care Medicine</span><span>, May 1, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834424"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834424"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834424; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834424]").text(description); $(".js-view-count[data-work-id=48834424]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834424; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834424']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834424]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834424,"title":"Lung inflammation early in cystic fibrosis: bugs are indicted, but the defense is guilty","internal_url":"https://www.academia.edu/48834424/Lung_inflammation_early_in_cystic_fibrosis_bugs_are_indicted_but_the_defense_is_guilty","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834423"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834423/Parthenolide_inhibits_I%CE%BAB_kinase_NF_KB_activation_and_inflammatory_response_in_cystic_fibrosis_cells_and_mice"><img alt="Research paper thumbnail of Parthenolide inhibits I魏B kinase, NF-KB activation, and inflammatory response in cystic fibrosis cells and mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834423/Parthenolide_inhibits_I%CE%BAB_kinase_NF_KB_activation_and_inflammatory_response_in_cystic_fibrosis_cells_and_mice">Parthenolide inhibits I魏B kinase, NF-KB activation, and inflammatory response in cystic fibrosis cells and mice</a></div><div class="wp-workCard_item"><span>American Journal of Respiratory Cell and Molecular Biology</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834423"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834423"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834423; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834423]").text(description); $(".js-view-count[data-work-id=48834423]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834423; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834423']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834423]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834423,"title":"Parthenolide inhibits I魏B kinase, NF-KB activation, and inflammatory response in cystic fibrosis cells and mice","internal_url":"https://www.academia.edu/48834423/Parthenolide_inhibits_I%CE%BAB_kinase_NF_KB_activation_and_inflammatory_response_in_cystic_fibrosis_cells_and_mice","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834422"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834422/Assessment_of_protein_antibody_response_in_patients_with_suspected_immune_deficiency"><img alt="Research paper thumbnail of Assessment of protein antibody response in patients with suspected immune deficiency" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834422/Assessment_of_protein_antibody_response_in_patients_with_suspected_immune_deficiency">Assessment of protein antibody response in patients with suspected immune deficiency</a></div><div class="wp-workCard_item"><span>Annals of Allergy Asthma Immunology Official Publication of the American College of Allergy Asthma Immunology</span><span>, Mar 1, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834422"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834422"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834422; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834422]").text(description); $(".js-view-count[data-work-id=48834422]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834422; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834422']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834422]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834422,"title":"Assessment of protein antibody response in patients with suspected immune deficiency","internal_url":"https://www.academia.edu/48834422/Assessment_of_protein_antibody_response_in_patients_with_suspected_immune_deficiency","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834421"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/48834421/Inflammation_in_the_lung_in_cystic_fibrosis"><img alt="Research paper thumbnail of Inflammation in the lung in cystic fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/67253891/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/48834421/Inflammation_in_the_lung_in_cystic_fibrosis">Inflammation in the lung in cystic fibrosis</a></div><div class="wp-workCard_item"><span>Clin Rev Allergy Immunol</span><span>, 1991</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Although the relationship between the basic cellular defect in Cystic Fibrosis (CF) and the facto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Although the relationship between the basic cellular defect in Cystic Fibrosis (CF) and the factors that predispose the CF patient to colonization with Pseudornonas aeruginosa remain undefined, it</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fd021308009ac6fb25255954c8df379b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":67253891,"asset_id":48834421,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/67253891/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834421"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834421"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834421; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834421]").text(description); $(".js-view-count[data-work-id=48834421]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834421; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834421']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fd021308009ac6fb25255954c8df379b" } } $('.js-work-strip[data-work-id=48834421]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834421,"title":"Inflammation in the lung in cystic fibrosis","internal_url":"https://www.academia.edu/48834421/Inflammation_in_the_lung_in_cystic_fibrosis","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[{"id":67253891,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/67253891/thumbnails/1.jpg","file_name":"bf0291453820210507-5929-1uyx90f.pdf","download_url":"https://www.academia.edu/attachments/67253891/download_file","bulk_download_file_name":"Inflammation_in_the_lung_in_cystic_fibro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/67253891/bf0291453820210507-5929-1uyx90f-libre.pdf?1620414310=\u0026response-content-disposition=attachment%3B+filename%3DInflammation_in_the_lung_in_cystic_fibro.pdf\u0026Expires=1739840592\u0026Signature=B~KeaJO~1lbXTLiYfQ4P4gOlFLV7gwG~bK6tplEVFhm-GsGlWqy09GZsgoqY-87oimwISRgS00O8Js6He6ubF5PgP-ZSzA5a4XnmfzWUG2hMwvLjLpoGimrBx2sCQmduVBcdWR9EeAYiNufD5Sq16urHc0It4JHYAD0Q-wsYLkiloR92y4oMcRg9Gvzc5JD1tgCOGrH3bpDgyKAIxObZKt571-twvS3PLVghWWn8W0ST2AOjGH9~JWC3hj8a44acyPaRM2od0towIa3e6pXKGSKxjTg6oQvFHeOUkCNLLhOyip0JMRCamRFr2ZVI90W8xOmE4bAY3kyjHWE27RmR4Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834420"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834420/Intravenous_%CE%B3_globulin_therapy_in_bronchial_asthma"><img alt="Research paper thumbnail of Intravenous 纬-globulin therapy in bronchial asthma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834420/Intravenous_%CE%B3_globulin_therapy_in_bronchial_asthma">Intravenous 纬-globulin therapy in bronchial asthma</a></div><div class="wp-workCard_item"><span>Allergy and Asthma Proceedings</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834420"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834420"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834420; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834420]").text(description); $(".js-view-count[data-work-id=48834420]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834420; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834420']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834420]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834420,"title":"Intravenous 纬-globulin therapy in bronchial asthma","internal_url":"https://www.academia.edu/48834420/Intravenous_%CE%B3_globulin_therapy_in_bronchial_asthma","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834419"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834419/Allergic_bronchopulmonary_aspergillosis_and_common_variable_hypogammaglobulinemia_in_an_adult_male_patient_Case_report"><img alt="Research paper thumbnail of Allergic bronchopulmonary aspergillosis and common variable hypogammaglobulinemia in an adult male patient: Case report" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834419/Allergic_bronchopulmonary_aspergillosis_and_common_variable_hypogammaglobulinemia_in_an_adult_male_patient_Case_report">Allergic bronchopulmonary aspergillosis and common variable hypogammaglobulinemia in an adult male patient: Case report</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 1996</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834419"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834419"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834419; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834419]").text(description); $(".js-view-count[data-work-id=48834419]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834419; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834419']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834419]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834419,"title":"Allergic bronchopulmonary aspergillosis and common variable hypogammaglobulinemia in an adult male patient: Case report","internal_url":"https://www.academia.edu/48834419/Allergic_bronchopulmonary_aspergillosis_and_common_variable_hypogammaglobulinemia_in_an_adult_male_patient_Case_report","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834418"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834418/Subcutaneous_Immunoglobulin_Replacement_Therapy_in_Infants_and_Children_with_Primary_Immunodeficiencies"><img alt="Research paper thumbnail of Subcutaneous Immunoglobulin Replacement Therapy in Infants and Children with Primary Immunodeficiencies" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834418/Subcutaneous_Immunoglobulin_Replacement_Therapy_in_Infants_and_Children_with_Primary_Immunodeficiencies">Subcutaneous Immunoglobulin Replacement Therapy in Infants and Children with Primary Immunodeficiencies</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, Feb 1, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834418"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834418"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834418; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834418]").text(description); $(".js-view-count[data-work-id=48834418]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834418; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834418']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834418]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834418,"title":"Subcutaneous Immunoglobulin Replacement Therapy in Infants and Children with Primary Immunodeficiencies","internal_url":"https://www.academia.edu/48834418/Subcutaneous_Immunoglobulin_Replacement_Therapy_in_Infants_and_Children_with_Primary_Immunodeficiencies","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834417"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834417/Immunoglobulins_in_the_newborn"><img alt="Research paper thumbnail of Immunoglobulins in the newborn" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834417/Immunoglobulins_in_the_newborn">Immunoglobulins in the newborn</a></div><div class="wp-workCard_item"><span>Curr Opin Infect Dis</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834417"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834417"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834417; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834417]").text(description); $(".js-view-count[data-work-id=48834417]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834417; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834417']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834417]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834417,"title":"Immunoglobulins in the newborn","internal_url":"https://www.academia.edu/48834417/Immunoglobulins_in_the_newborn","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834416"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834416/Management_of_PrimaryAntibody_Deficiency_with_Replacement_Therapy_Summary_of_Guidelines"><img alt="Research paper thumbnail of Management of PrimaryAntibody Deficiency with Replacement Therapy : Summary of Guidelines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834416/Management_of_PrimaryAntibody_Deficiency_with_Replacement_Therapy_Summary_of_Guidelines">Management of PrimaryAntibody Deficiency with Replacement Therapy : Summary of Guidelines</a></div><div class="wp-workCard_item"><span>Immunology and Allergy Clinics of North America</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This article summarizes the guidelines for using replacement therapy in the management of patient...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This article summarizes the guidelines for using replacement therapy in the management of patients who have primary antibody deficiency.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834416"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834416"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834416; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834416]").text(description); $(".js-view-count[data-work-id=48834416]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834416; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834416']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834416]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834416,"title":"Management of PrimaryAntibody Deficiency with Replacement Therapy : Summary of Guidelines","internal_url":"https://www.academia.edu/48834416/Management_of_PrimaryAntibody_Deficiency_with_Replacement_Therapy_Summary_of_Guidelines","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834415"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834415/Circulating_Immune_Complexes_and_Glomerulonephritis_in_a_Patient_with_Congenital_Absence_of_the_Third_Component_of_Complement"><img alt="Research paper thumbnail of Circulating Immune Complexes and Glomerulonephritis in a Patient with Congenital Absence of the Third Component of Complement" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834415/Circulating_Immune_Complexes_and_Glomerulonephritis_in_a_Patient_with_Congenital_Absence_of_the_Third_Component_of_Complement">Circulating Immune Complexes and Glomerulonephritis in a Patient with Congenital Absence of the Third Component of Complement</a></div><div class="wp-workCard_item"><span>N Engl J Med</span><span>, 1983</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... ABSENCE OF THE THIRD COMPONENT OF COMPLEMENT Melvin Berger, MD, Ph.D., James E. Balow, MD, Cu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... ABSENCE OF THE THIRD COMPONENT OF COMPLEMENT Melvin Berger, MD, Ph.D., James E. Balow, MD, Curtis B. Wilson, MD, and Michael M. Frank, MD THE third component of complement (C3) is criti-cally involved in host defense and the mainte-nance of normal ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834415"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834415"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834415; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834415]").text(description); $(".js-view-count[data-work-id=48834415]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834415; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834415']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834415]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834415,"title":"Circulating Immune Complexes and Glomerulonephritis in a Patient with Congenital Absence of the Third Component of Complement","internal_url":"https://www.academia.edu/48834415/Circulating_Immune_Complexes_and_Glomerulonephritis_in_a_Patient_with_Congenital_Absence_of_the_Third_Component_of_Complement","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834414"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834414/_74_Third_component_of_human_complement_C3"><img alt="Research paper thumbnail of [74] Third component of human complement: C3" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834414/_74_Third_component_of_human_complement_C3">[74] Third component of human complement: C3</a></div><div class="wp-workCard_item"><span>Methods in Enzymology</span><span>, 1990</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834414"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834414"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834414; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834414]").text(description); $(".js-view-count[data-work-id=48834414]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834414; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834414']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834414]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834414,"title":"[74] Third component of human complement: C3","internal_url":"https://www.academia.edu/48834414/_74_Third_component_of_human_complement_C3","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="48834413"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/48834413/Normal_bronchial_epithelial_cells_produce_the_anti_inflammatory_cytokine_IL_10_which_is_downregulated_in_CF_while_IL_8_is_upregulated"><img alt="Research paper thumbnail of Normal bronchial epithelial cells produce the anti-inflammatory cytokine IL-10, which is downregulated in CF, while IL-8 is upregulated" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/48834413/Normal_bronchial_epithelial_cells_produce_the_anti_inflammatory_cytokine_IL_10_which_is_downregulated_in_CF_while_IL_8_is_upregulated">Normal bronchial epithelial cells produce the anti-inflammatory cytokine IL-10, which is downregulated in CF, while IL-8 is upregulated</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="48834413"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="48834413"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48834413; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48834413]").text(description); $(".js-view-count[data-work-id=48834413]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48834413; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='48834413']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=48834413]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":48834413,"title":"Normal bronchial epithelial cells produce the anti-inflammatory cytokine IL-10, which is downregulated in CF, while IL-8 is upregulated","internal_url":"https://www.academia.edu/48834413/Normal_bronchial_epithelial_cells_produce_the_anti_inflammatory_cytokine_IL_10_which_is_downregulated_in_CF_while_IL_8_is_upregulated","owner_id":38990937,"coauthors_can_edit":true,"owner":{"id":38990937,"first_name":"Melvin","middle_initials":null,"last_name":"Berger","page_name":"BergerMelvin","domain_name":"independent","created_at":"2015-11-23T12:17:10.855-08:00","display_name":"Melvin Berger","url":"https://independent.academia.edu/BergerMelvin"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "775fd4467f38c6574edc521bfa05d6d084e870874836f476afd0506e55f68e71", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="MvDgeHW9l9YZaDT3buJeGVoE3CgN0JGk5yJPFekGvraa316eptyrdeCqC3fnB_QqhrIL3fbL-Ngl9uLgRhxQVg" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/BergerMelvin" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="88lRQiZUw8od6pb2pigZOeVYJTsgzyQNR0jemd1nudtb5u-k9TX_aeQoqXYvzbMKOe7yztvUTXGFnHNscn1XOw" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>