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{"work":{"id":13858389,"created_at":"2015-07-09T22:06:12.136-07:00","from_world_paper_id":139123019,"updated_at":"2021-01-17T18:49:38.518-08:00","_data":{"publication_date":"2007,,","publication_name":"Human Vaccines"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"The Immunogenicity and Reactogenicity of a New DTPw-HBV Vaccine as a Primary and Booster Vaccination Dourse in Healthy Infants","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [32949940,33007297]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div 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and containing 2.5 microg polyribosyl-ribitol-phosphate (PRP) was assessed. Primary vaccination with the new DTPw-HBV/Hib vaccine was immunogenic and of comparable tolerability to commercially available Tritanrix HepB/Hiberix. Children were boosted with DTPw-HBV, DTPw-HBV/Hib or separate DTPw-HBV+Hiberix. Immune memory was assessed through administration of 10 microg PRP polysaccharide. Anti-PRP antibody GMCs increased substantially after the challenge in DTPw-HBV/Hib-primed subjects indicating the presence of immune memory. One month after the booster dose, 100% of subjects had seroprotective antibody concentrations against PRP, diphtheria and tetanus, &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;95% were seroprotected against hepatitis B, &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or =94.0% had a pertussis booster response. Substantial increases in antibody GMCs against all antigens were observed. Swelling &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;20 mm was the most common Grade 3 solicited symptom reported (up to 26.0% of subjects). Fever &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;39.5 degrees C was uncommon (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;2.5%). Eleven large swelling reactions were reported; none involved an adjacent joint. One serious adverse event occurred that was considered unrelated to vaccination. This new DTPw-HBV/Hib vaccine with new vaccine components and 2.5 microg PRP induced effective priming against Hib evidenced by a vigorous anamnestic response on exposure to PRP polysaccharide. The booster dose was immunogenic and the safety profile was acceptable. 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href="https://www.academia.edu/16664774/A_new_DTPw_HBV_Hib_vaccine_Immune_memory_after_primary_vaccination_and_booster_dosing_in_the_second_year_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="92826712" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine">Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="249836346" href="https://independent.academia.edu/TheinAungMyat">Aung Myat Thein</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Pediatric Infectious Disease Journal, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reactogenicity and Immunogenicity Profiles of a Novel Pentavalent Diphtheria-Tetanus???Whole Cell Pertussis???Hepatitis B and Haemophilus Influenzae Type B Vaccine","attachmentId":95732621,"attachmentType":"pdf","work_url":"https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92826712/Reactogenicity_and_Immunogenicity_Profiles_of_a_Novel_Pentavalent_Diphtheria_Tetanus_Whole_Cell_Pertussis_Hepatitis_B_and_Haemophilus_Influenzae_Type_B_Vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="49725247" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/49725247/A_phase_III_randomized_controlled_study_to_assess_the_immunogenicity_and_tolerability_of_DTPw_HBV_Hib_a_liquid_pentavalent_vaccine_in_Indian_infants">A phase III randomized, controlled study to assess the immunogenicity and tolerability of DTPw-HBV-Hib, a liquid pentavalent vaccine in Indian infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="154784666" href="https://independent.academia.edu/ProfVishwanathPatil">Prof. Vishwanath Patil</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A phase III randomized, controlled study to assess the immunogenicity and tolerability of DTPw-HBV-Hib, a liquid pentavalent vaccine in Indian infants","attachmentId":67987438,"attachmentType":"pdf","work_url":"https://www.academia.edu/49725247/A_phase_III_randomized_controlled_study_to_assess_the_immunogenicity_and_tolerability_of_DTPw_HBV_Hib_a_liquid_pentavalent_vaccine_in_Indian_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/49725247/A_phase_III_randomized_controlled_study_to_assess_the_immunogenicity_and_tolerability_of_DTPw_HBV_Hib_a_liquid_pentavalent_vaccine_in_Indian_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="11441050" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants">Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27850479" href="https://independent.academia.edu/JuanLopez251">Juan Lopez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">The aim of this single-blind, parallel trial was to assess whether the hepatitis B (HB) component of a DTPw-HB vaccine interferes with the immune response to the other three components when administered at 3, 5 and 7 months of age. One hundred and six infants were randomized to receive three doses of DTPw or DTPw-HB vaccines. Seroprotection (or seroresponse) rates and geometric mean titers (GMT) of antibodies were assessed 3–6 weeks after the third dose. Anti-diphtheria, anti-tetanus and anti-Bordetella pertussis antibodies were measured by ELISA and anti-HBs by radio-immunoassay. Local and general signs and symptoms were recorded for a 4-day follow-up period after each vaccination. After the full vaccination course all subjects in both groups had seroprotective titers (≥0.1 IU ml−1) against diphtheria and tetanus and seroresponded (titers ≥15 EL.U ml−1) to B. pertussis, and there was no significant difference between groups in relation to GMT. All subjects vaccinated with DTPw-HB had seroprotective levels (≥10 mIU ml−1) of anti-HBs antibodies after the third dose (GMT of 2318 mIU ml−1). Overall there were no significant differences between groups in relation to the incidence of local and general symptoms. These results show that the HB component did not interfere with the immune response to the other three components of the vaccine.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatitis B component does not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants","attachmentId":46706768,"attachmentType":"pdf","work_url":"https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/11441050/Hepatitis_B_component_does_not_interfere_with_the_immune_response_to_diphtheria_tetanus_and_whole_cell_Bordetella_pertussis_components_of_a_quadrivalent_DTPw_HB_vaccine_a_controlled_trial_in_healthy_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="99497823" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants">Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="176086834" href="https://independent.academia.edu/ZeppFred">Fred Zepp</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatrics, 2002</p><p class="ds-related-work--abstract ds2-5-body-sm">Objective. Combination vaccines simplify vaccine administration and have the potential to promote compliance and cost-effectiveness by decreasing the number of injections needed to immunize a child. The objective of this study was to assess the safety and reactogenicity of the diphtheria-tetanus toxoid-acellular pertussis-hepatitis B virus-inactivated polio virus (DTPa-HBV-IPV) vaccine when coadministered with different Haemophilus influenzae type B (Hib) vaccines in comparison with separate, commercially available, control vaccines in a 3-dose primary vaccination series. Methods. An open-label, randomized, parallel-group study in 5318 infants who were 8 to 16 weeks of age at enrollment was conducted in 90 centers in Germany. The incidence of adverse events that occurred in infants who received the DTPa-HBV-IPV candidate vaccine coadministered with 1 of 4 different Hib vaccines (given in separate sites; groups 1–4) was compared with the incidence that occurred in infants who receive...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given Along With Commercial Hib Vaccines inComparison With Separate Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants","attachmentId":100570559,"attachmentType":"pdf","work_url":"https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/99497823/Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="4835328" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age">Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="6263365" href="https://independent.academia.edu/AlbertoPerez7">Alberto Perez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age","attachmentId":49609185,"attachmentType":"pdf","work_url":"https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":44871874,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":44871874,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_44871874" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/81699188/Immunogenicity_and_reactogenicity_of_DTPw_HB_Hib_vaccine_administered_to_Colombian_infants_after_a_birth_dose_of_hepatitis_B_vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="17527248" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given">Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37298606" href="https://unimedizin-mainz.academia.edu/ClaudiusMeyer">Claudius Meyer</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Concomitant Administration ofDTPa, Hib, and OPV Vaccines in Infants Along With Commercial Hib Vaccines inComparison With Separate Safety and Reactogenicity of a Novel DTPa-HBV-IPV Combined Vaccine Given","attachmentId":42251428,"attachmentType":"pdf","work_url":"https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/17527248/Concomitant_Administration_ofDTPa_Hib_and_OPV_Vaccines_in_Infants_Along_With_Commercial_Hib_Vaccines_inComparison_With_Separate_Safety_and_Reactogenicity_of_a_Novel_DTPa_HBV_IPV_Combined_Vaccine_Given"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div 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data-author-id="26641596" href="https://independent.academia.edu/EugeniodeFrutos">Eugenio de Frutos</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36236693" href="https://independent.academia.edu/JosepMar%C3%A9s">Josep Marés</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparison of the reactogenicity and immunogenicity of a combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio (DTPa–HBV–IPV) vaccine, mixed with the Haemophilus influenzae type b (Hib) conjugate vaccine and administered as a single injection, with the DTPa–IPV/Hib 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href="https://www.academia.edu/16795810/Comparison_of_the_reactogenicity_and_immunogenicity_of_a_combined_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_DTPa_HBV_IPV_vaccine_mixed_with_the_Haemophilus_influenzae_type_b_Hib_conjugate_vaccine_and_administered_as_a_single_injection_with_the_DTPa_IPV_Hib_and_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="2495889" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life">Immunogenicity study of a combined diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis vaccine used to reconstitute a freeze-dried Haemophilus influenzae type b vaccine (DTaP-IPV//PRP-T) administered simultaneously with a hepatitis B vaccine at two, three and four months of life</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2293675" href="https://ankara.academia.edu/BetulUlukol">Betul Ulukol</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/2495889/Immunogenicity_study_of_a_combined_diphtheria_tetanus_acellular_pertussis_inactivated_poliomyelitis_vaccine_used_to_reconstitute_a_freeze_dried_Haemophilus_influenzae_type_b_vaccine_DTaP_IPV_PRP_T_administered_simultaneously_with_a_hepatitis_B_vaccine_at_two_three_and_four_months_of_life"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="26688399" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age">Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus- Haemophilus influenzae type b vaccines administered at 3, 5 and 11–12 months of age</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50682354" href="https://independent.academia.edu/MahmoodJedditehrani">Mahmood Jeddi-tehrani</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus- Haemophilus influenzae type b vaccines administered at 3, 5 and 11–12 months of age","attachmentId":46970339,"attachmentType":"pdf","work_url":"https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/26688399/Immunogenicity_and_reactogenicity_of_two_diphtheria_tetanus_acellular_pertussis_hepatitis_B_inactivated_polio_virus_Haemophilus_influenzae_type_b_vaccines_administered_at_3_5_and_11_12_months_of_age"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="80504950" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/80504950/Primary_and_booster_vaccination_with_DTPw_HB_Hib_pentavalent_vaccine_in_Costa_Rican_children_who_had_received_a_birth_dose_of_hepatitis_B_vaccine">Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="183821415" href="https://independent.academia.edu/MarcFourneau">Marc Fourneau</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Revista Panamericana de Salud P�blica, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine","attachmentId":86864492,"attachmentType":"pdf","work_url":"https://www.academia.edu/80504950/Primary_and_booster_vaccination_with_DTPw_HB_Hib_pentavalent_vaccine_in_Costa_Rican_children_who_had_received_a_birth_dose_of_hepatitis_B_vaccine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/80504950/Primary_and_booster_vaccination_with_DTPw_HB_Hib_pentavalent_vaccine_in_Costa_Rican_children_who_had_received_a_birth_dose_of_hepatitis_B_vaccine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="97724322" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/97724322/Immunogenicity_and_safety_of_an_indigenously_manufactured_reconstituted_pentavalent_DTwP_HBV_Hib_vaccine_in_comparison_with_a_foreign_competitor_following_primary_and_booster_immunization_in_Indian_children">Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian children</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="259596214" href="https://independent.academia.edu/vikasverma408">vikas verma</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Human Vaccines, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunogenicity and safety of an indigenously manufactured reconstituted pentavalent (DTwP-HBV+Hib) vaccine in comparison with a foreign competitor following primary and booster immunization in Indian 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="4278383" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections">Primary vaccination of infants with diphtheria-tetanus-acellular pertussis–hepatitis B virus– inactivated polio virus and Haemophilus influenzae type b vaccines given as either separate or mixed injections</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5193659" href="https://independent.academia.edu/OrtizEsteban">Esteban Ortiz</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Pediatrics, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Primary vaccination of infants with diphtheria-tetanus-acellular pertussis–hepatitis B virus– inactivated polio virus and Haemophilus influenzae type b vaccines given as either separate or mixed injections","attachmentId":49963493,"attachmentType":"pdf","work_url":"https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/4278383/Primary_vaccination_of_infants_with_diphtheria_tetanus_acellular_pertussis_hepatitis_B_virus_inactivated_polio_virus_and_Haemophilus_influenzae_type_b_vaccines_given_as_either_separate_or_mixed_injections"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="16626614" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants">Safety, reactogenicity and immunogenicity of a combined hexavalent tetanus, diphtheria, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate vaccine, for primary immunization of infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35974695" href="https://unibas.academia.edu/UlrichHeininger">Ulrich Heininger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Vaccine, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Safety, reactogenicity and immunogenicity of a combined hexavalent tetanus, diphtheria, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate vaccine, for primary immunization of infants","attachmentId":42424809,"attachmentType":"pdf","work_url":"https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/16626614/Safety_reactogenicity_and_immunogenicity_of_a_combined_hexavalent_tetanus_diphtheria_acellular_pertussis_hepatitis_B_inactivated_poliovirus_vaccine_and_Haemophilus_influenzae_type_b_conjugate_vaccine_for_primary_immunization_of_infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="73781061" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73781061/Immunogenicity_and_Reactogenicity_of_DTPa_IPV_Hib_Vaccine_Co_administered_With_Hepatitis_B_Vaccine_for_Primary_and_Booster_Vaccination_of_Taiwanese_Infants">Immunogenicity and Reactogenicity of DTPa-IPV/Hib Vaccine Co-administered With Hepatitis B Vaccine for Primary and Booster Vaccination of Taiwanese Infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217595099" href="https://independent.academia.edu/YuChiaHsieh">Yu Chia Hsieh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the Formosan Medical Association, 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href="https://www.academia.edu/73781061/Immunogenicity_and_Reactogenicity_of_DTPa_IPV_Hib_Vaccine_Co_administered_With_Hepatitis_B_Vaccine_for_Primary_and_Booster_Vaccination_of_Taiwanese_Infants"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="125179240" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/125179240/Immunogenicity_and_safety_of_DTPW_HEPB_HIB_PRP_T_vaccine_Pentavac_in_infants_aged_2_7_months_a_post_marketing_phase_4_clinical_trial_study">Immunogenicity and safety of DTPW-HEPB-HIB (PRP-T) vaccine (Pentavac) in infants aged 2–7 months: a post marketing phase 4 clinical trial study</a><div class="ds-related-work--metadata"><a 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