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Translator Projects | National Center for Advancing Translational Sciences
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class="first" data-drupal-link-system-path="node/27701">About Biomedical Data Translator</a> </li> <li> <a href="/research/research-activities/translator/performance-phase-qa" data-drupal-link-system-path="node/44092">Biomedical Data Translator Performance Phase — Questions and Answers</a> </li> <li> <a href="/research/research-activities/translator/faqs" data-drupal-link-system-path="node/27700">Frequently Asked Questions</a> </li> <li class="active active-trail last"> <a href="/research/research-activities/translator/projects" class="active active-trail last active-trail is-active" data-drupal-link-system-path="node/27661">Translator Projects</a> </li> </ul> </nav> </div> <section> <div class="container news-content Advancing"> <div class="paragraph paragraph--type--body-content paragraph--view-mode--default"> <style> svg.mailto { display:none; } div.accordion-item-header.active + div.accordion-item-body svg.mailto { display: inline; } footer svg.mailto { display: inline; } </style> <p>With the goal of developing a Biomedical Data Translator to combine the vast amounts of currently available medical research data and speed up the development of new treatments, we gave awards to form project teams of experts from different leading universities and research institutions. In the first phase of the program, teams established feasibility, producing new biological insights and figuring out novel therapeutic opportunities using a combination of existing literature, experimental characterization and clinical data. Translator awardees are now beginning in earnest to build the tools needed to support the combination of diverse data types and show the potential impact of mining those combined data using new analytical tools that promote the discovery of complex relationships between the data for the research community.</p><p><a href="/sites/default/files/NCATS_TranslatorInfographic_v2%20FINAL.jpg" download><img src="/sites/default/files/NCATS_TranslatorInfographic_v2%20FINAL.jpg" alt="A researcher types into the computer screen “predict treatments for disease y.” The query is sent to the Translator’s Autonomous Relay Agents (ARAs) to determine how best to answer the query. The ARA will then break the query into smaller tasks that are transmitted to rich, specialty knowledge bases called Knowledge Providers (KPs). This process will be iterative, such that the ARAs and KPs can build on information from the others. The last sequence is the results of the query showing up on the computer screen of the researcher."></a></p><div class="caption-left-lg"><div class="caption-text" style="padding-top:1%;"><p>Credit: National Center for Advancing Translational Sciences</p><p>Click the image above to download the Translator process graphic.</p><p><strong>Translator Draft Architecture.</strong> A researcher will be able to use NCATS Biomedical Data Translator to help answer difficult biomedical questions like, “predict treatments for disease Y.” The query will be sent to Translator’s Autonomous Relay Agents (ARAs) to determine how best to answer the query. The ARA will break the query into smaller tasks that are transmitted to rich, specialty knowledge bases called Knowledge Providers (KPs). This process will be iterative, such that the ARAs and KPs can build on information from the others. Researchers will be able to explore this distilled knowledge and help them to develop new research hypotheses that lead to new scientific discoveries!</p></div></div> </div> </div> </section> <section> <div class="container news-content Advancing"> <h2 class="section-heading">Translator Investigators</h2> <div class="description"> <style> div.container.accordion-col div div h2 { display: none; } </style><p>The following Translator Investigators are grouped by team name.</p> </div> <div class="container accordion-col"> <div class="row"> <div class="col-12"> <h2>Open Opportunities</h2> <div class="accordion"> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">(im)Prove Agent</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div>Institute for Systems Biology</div><div><p><a href="mailto:sui.huang@isbscience.org">Sui Huang</a></p></div><div>University of California San Francisco</div><div><p><a href="mailto:Sergio.Baranzini@ucsf.edu">Sergio Baranzini</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Clinical Data Services Provider</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Columbia University</strong></div><div><p><a href="mailto:ct2865@columbia.edu">Casey Ta</a><br><a href="mailto:cw2384@columbia.edu">Chunhua Weng</a></p></div><div><strong>Maastricht University</strong></div><div><p><a href="mailto:michel.dumontier@maastrichtuniversity.nl">Michel Dumontier</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Connection Hypothesis Provider</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Dartmouth University</strong></div><div><p><a href="mailto:Eugene.Santos.Jr@dartmouth.edu">Eugene Santos</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Expander Agent</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Institute for Systems Biology</strong></div><div><p><a href="mailto:edeutsch@systemsbiology.org">Eric Deutsch</a></p></div><div><strong>Oregon State University</strong></div><div><p><a href="mailto:stephen.ramsey@oregonstate.edu">Stephen Ramsey</a></p></div><div><strong>Pennsylvania State University</strong></div><div><p><a href="mailto:dmk333@psu.edu">David Koslicki</a></p></div><div><strong>Drexel University</strong></div><div><p><a href="mailto:rosina@drexel.edu">Rosina Weber</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Exploring Agent</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Scripps Research</strong></div><div><p><a href="mailto:asu@scripps.edu">Andrew Su</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Exposures Provider</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Renaissance Computing Institute at University of North Carolina, Chapel Hill</strong></div><div><p><a href="mailto:ahalt@renci.org">Stanley Ahalt</a><br><a href="mailto:ashok@renci.org">Ashok Krishnamurthy</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Genetics Provider</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Broad Institute</strong></div><div><p><a href="mailto:flannick@broadinstitute.org">Jason Flannick</a></p><p><a href="mailto:vdancik@broadinstitute.org">Vlado Dancik</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Multiomics Provider</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Institute for Systems Biology</strong></div><div><p><a href="mailto:gglusman@isbscience.org">Gwênlyn Glusman</a><br><a href="mailto:jennifer.hadlock@isbscience.org">Jennifer Hadlock</a><br><a href="mailto:ishmulevich@isbscience.org">Ilya Schmulevich</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Ranking Agent</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>CoVar Applied Technologies</strong></div><div><p><a href="mailto:patrick@covar.com">Patrick Wang</a></p></div><div><strong>Renaissance Computing Institute at University of North Carolina, Chapel Hill</strong></div><div><p><a href="mailto:alex_tropsha@unc.edu">Alexander Tropsha</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Service Provider</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Scripps Research</strong></div><div><p><a href="mailto:cwu@scripps.edu">Chunlei Wu</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Standards and Reference Implementation</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>Lawrence Berkeley National Laboratory</strong></div><div><p><a href="mailto:cjmungall@lbl.gov">Christopher Mungall</a></p></div><div><strong>Renaissance Computing Institute at University of North Carolina, Chapel Hill</strong></div><div><p><a href="mailto:bizon@renci.org">Christopher Bizon</a></p></div><div><strong>University of Colorado Anschutz School of Medicine</strong></div><div><p><a href="mailto:matt@tislab.org">Matthew Brush</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Text Mining Provider</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>University of Colorado Anschutz School of Medicine</strong></div><div><p><a href="mailto:william.baumgartner@cuanschutz.edu">William Baumgartner</a></p></div> </div> </div> </div> <div class="accordion-item"> <div class="accordion-item-header"> <h5 class="d-block">Unsecret Agent</h5> <p><small></small></p> </div> <div class="accordion-item-body"> <hr> <div class="accordion-item-body-content"> <div><strong>University of Alabama at Birmingham</strong></div><div><p><a href="mailto:webyrd@uab.edu">William Byrd</a><br><a href="mailto:might@uab.edu">Matthew Might</a></p></div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </div> </article> </div> <div id="block-footercss" class="block block-block-content block-block-content2db33373-6fb7-49c5-be2f-83266eddea39"> <style type="text/css"> ul#superfish-navigation li { line-height:1.25; } .region-header .block-superfish ul.sf-menu li a {padding-right:40px !important;} @media (min-width: 1200px) { ul.sf-menu.sf-navigation li.menuparent ul {width:280px !important;} } .main-content article .menu--navigation { display:flex; flex-wrap: nowrap; justify-content: space-between; align-items: stretch; } .main-content article .menu--navigation li { flex: 1 1 0; width: 0; align-items: center; display: flex; justify-content: center; } .main-content article .menu--navigation li .dropdown-toggle { white-space: unset; } .image-box img, div.col-md-4.col-lg-2 img { height: auto; } .caption-left-md { float: left; width: 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