CINXE.COM

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about="/products/cell-therapy/monitoring-efficacy-and-toxicity" typeof="sioc:Item foaf:Document"> <header> <span property="dc:title" content="Monitoring Cell and Gene Therapy - Efficacy and Toxicity" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> </header> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><div class="organoids"> <style type="text/css">/* basic */ .btn-tertiary {margin-bottom: 05px;} .bg-split {background: linear-gradient(to right,#e8f6fe 0,#e8f6fe 50%,#efefef 50%,#efefef 100%);padding: 30px 0;} @media (max-width: 769px) { .bg-split {background: #e8f6fe;} } .organoids img {margin:15px 0;} .padded_row {padding: 15px 0;} .cultrex_table_wrapper { display: block; height: auto; width: 100%; overflow-x: scroll; } #Gasteroids, #Enteroids, #Colonoids, 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To view our complete solutions for <a href="http://www.bio-techne.com/clinical-solutions/cell-and-gene-therapy-solutions" target="_blank">Cell and Gene Therapy</a> including GMP-grade reagents and 21 CFR Part 11-compliant analytical instrumentation, visit bio-techne.com.</p> </div> </div> </div> </div> <div> </div> <div class="row"> <div class="container"> <div class="row"> <div class="discovery col-xs-12"><a class="btn btn-tertiary" href="/products/cell-therapy">Discovery Solutions for Cell and Gene Therapy</a> <a class="btn btn-tertiary" href="/products/cell-therapy/cell-separation-cell-and-gene-therapy">Cell Separation</a> <a class="btn btn-tertiary" href="/products/cell-therapy/cell-culture-cell-and-gene-therapy">Cell Culture</a> <a class="btn btn-tertiary" href="https://www.rndsystems.com/services/genome-engineering" target="_blank">Genome Editing</a> <a class="btn btn-tertiary" href="/products/cell-therapy/quality-control-cell-and-gene-therapy">Product Release Testing</a></div> </div> </div> </div> <div> </div> <div> </div> <div class="row"> <div class="container"> <div class="quality col-xs-12 col-sm-2"><img alt="Monitoring Stem Cell Engraftment " class="image-responsive" src="https://resources.rndsystems.com/images/site/12272018-cgt-monitoring-graphic-1-engraftment.png?t=2" /></div> <div class="quality col-xs-12 col-sm-10"> <h2>Stem Cell Engraftment After Infusion</h2> <p>Keep a close eye on how your cell or gene therapy performs <em>in vivo</em>. Track cell homing to the target tissue, cell persistence in the target tissue, and continued cell function.</p> </div> </div> </div> <p> </p> <div class="row"> <div class="container"> <div class="col-xs-12 col-sm-12"> <div id="Engraftment"> <div aria-multiselectable="true" class="panel-group" id="engraftment" role="tablist"> <div class="panel panel-default"> <div class="panel-heading" id="engraftment" role="tab"> <h4 class="panel-title"><a aria-controls="engraftmentOne" aria-expanded="true" data-parent="#engraftment" data-toggle="collapse" href="#engraftmentOne" role="button">Products for Monitoring Engraftment</a></h4> </div> <div aria-expanded="true" aria-labelledby="engraftment" class="panel-collapse collapse in" id="engraftmentOne" role="tabpanel" style=""> <div class="panel-body"> <table cellpadding="0" cellspacing="0" width="100%"> <tbody> <tr> <td><a href="https://acdbio.com/" target="_blank">RNAscope</a><a href="/products/proteome-profiler-antibody-arrays" target="_blank"><span style="height: 0px; line-height: 1; vertical-align: baseline; position: relative; bottom: 1ex;">™</span></a><a href="https://acdbio.com/" target="_blank"> <em>in situ</em> Hybridization Assays</a> (at acd.com)<br />     Single-cell RNA expression analysis to localize your cell therapy in the target tissue</td> </tr> <tr> <td><a href="/products/epitope-tag-antibodies" target="_blank">Epitope Tag Antibodies</a><br />     For detection of tagged molecules in your genetic construct</td> </tr> <tr> <td><a href="/product-highlights/adoptive-cell-transfer-monitor-t-cell-exhaustion" target="_blank">Monitoring T Cell Exhaustion</a><br />     Reagents and assays to confirm that your cells don’t become over-activated <em>in vivo</em></td> </tr> <tr> <td><a href="https://www.novusbio.com/research-areas/cell-biology/Exosome-research-tools" target="_blank">Reagents and Assays for Exosome Research</a> (at novusbio.com)<br />     To monitor microvesicles released by your cell or gene therapy</td> </tr> <tr> <td>Suicide Switch Triggering and Monitoring for Cell Therapy Inactivation<br />     <a href="https://www.tocris.com/cell-biology/apoptosis-inducers" target="_blank">Apoptosis Inducer Compounds</a> (at tocris.com)<br />     <a href="/products/apoptosis-detection-kits-reagents" target="_blank">Apoptosis Detection Kits and Reagents</a></td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> </div> </div> <div> </div> <div> </div> <div class="row"> <div class="container"> <div class="quality col-xs-12 col-sm-2"><img alt="Systemic Host Response" class="image-responsive" src="https://resources.rndsystems.com/images/site/12272018-cgt-monitoring-graphic-2-systemic.png?t=2" /></div> <div class="quality col-xs-12 col-sm-10"> <h2>Systemic Host Response</h2> <p>Analyze how the host responds to your cell therapy. Our multiple assay platforms will give you flexibility to monitor circulating biomarkers of cytokine release syndrome, tissue and organ damage, and immunogenicity.</p> <p> </p> </div> </div> </div> <div class="row"> <div class="container"> <div class="col-xs-12 col-sm-12"> <div id="SystemicTissueResponse"> <div aria-multiselectable="true" class="panel-group" id="systemictissueresponse" role="tablist"> <div class="panel panel-default"> <div class="panel-heading" id="systemictissueresponse" role="tab"> <h3 class="panel-title"><a aria-controls="systemictissueresponseOne" aria-expanded="true" data-parent="#systemictissueresponse" data-toggle="collapse" href="#systemictissueresponseOne" role="button">Assay Platforms for Analysis of Secreted Molecules</a></h3> </div> <div aria-expanded="true" aria-labelledby="systemictissueresponse" class="panel-collapse collapse in" id="systemictissueresponseOne" role="tabpanel" style=""> <div class="panel-body"> <table cellpadding="0" cellspacing="0" width="100%"> <tbody> <tr> <td><a href="/products/proteome-profiler-antibody-arrays" target="_blank">Proteome Profiler<sup>™</sup> Antibody Arrays</a><br />     No specialized equipment required; affordable screening tool for discovery-level research</td> </tr> <tr> <td><a href="/products/elisas#reagents" target="_blank">DuoSet</a><a href="/products/proteome-profiler-antibody-arrays" target="_blank"><span style="height: 0px; line-height: 1; vertical-align: baseline; position: relative; bottom: 1ex;">™</span></a><a href="/products/elisas#reagents" target="_blank"> ELISA Development Reagents</a><br />     Flexible and economical for discovery-level research; over 1,000 available</td> </tr> <tr> <td><a href="/products/elisas#elisa" target="_blank">Quantikine</a><a href="/products/proteome-profiler-antibody-arrays" target="_blank"><span style="height: 0px; line-height: 1; vertical-align: baseline; position: relative; bottom: 1ex;">™</span></a><a href="/products/elisas#elisa" target="_blank"> ELISA Kits</a><br />     Industry gold standard ELISAs as you transition to clinical-level research; over 450 available</td> </tr> <tr> <td><a href="/products/luminex-assays-and-high-performance-assays" target="_blank">Luminex</a><a href="/products/proteome-profiler-antibody-arrays" target="_blank"><span style="height: 0px; line-height: 1; vertical-align: baseline; position: relative; bottom: 1ex;">™</span></a><a href="/products/luminex-assays-and-high-performance-assays" target="_blank"> Assays and Luminex High Performance Assays</a><br />     Quantitative multiplex for up to 100 analytes and for translational medicine applications</td> </tr> <tr> <td><a href="https://www.proteinsimple.com/ella.html" target="_blank">Simple Plex<sup>™</sup> Assays</a> (at proteinsimple.com)<br />     Automated, parallel immunoassays for translational medicine applications; results in < 1 hour</td> </tr> <tr> <td><a href="https://www.proteinsimple.com/simple_western_overview.html" target="_blank">Simple Western<sup>™</sup> Assays</a> (at proteinsimple.com)<br />     Automated, 3-hour capillary-based immunoassays and size assays for translational medicine applications</td> </tr> <tr> <td><a href="https://www.biospacific.com/" target="_blank">Antibodies for Disease Biomarkers</a> (at biospacific.com)</td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> </div> </div> <div> </div> <div> </div> <div class="row"> <div class="container"> <div class="quality col-xs-12 col-sm-2"><img alt="Host Tissue Response" class="image-responsive" src="https://resources.rndsystems.com/images/site/12272018-cgt-monitoring-graphic-3-host-tissue.png?t=2" /></div> <div class="quality col-xs-12 col-sm-10"> <h2>Host Tissue Response to Cell Therapy</h2> <p>Evaluate the efficacy of your cell therapy in the tissue you’re targeting. Determine if your treatment is inducing tumor regression, tissue regeneration, angiogenesis, immune cell infiltration, apoptosis, fibrosis, or other relevant measures.</p> <p> </p> </div> </div> </div> <div class="row"> <div class="container"> <div class="col-xs-12 col-sm-12"> <div id="HostTissueResponse"> <div aria-multiselectable="true" class="panel-group" id="hosttissueresponse" role="tablist"> <div class="panel panel-default"> <div class="panel-heading" id="hosttissueresponse" role="tab"> <h3 class="panel-title"><a aria-controls="hosttissueresponseOne" aria-expanded="true" data-parent="#hosttissueresponse" data-toggle="collapse" href="#hosttissueresponseOne" role="button">Products for Monitoring Angiogenesis</a></h3> </div> <div aria-expanded="true" aria-labelledby="hosttissueresponse" class="panel-collapse collapse" id="hosttissueresponseOne" role="tabpanel" style=""> <div class="panel-body"> <table cellpadding="0" cellspacing="0" width="100%"> <tbody> <tr> <td><a href="/search?keywords=%22angiogenesis+array%22" target="_blank">Proteome Profiler<sup>™</sup> Angiogenesis Array Kits</a><br />     Simultaneous blot-based detection of >50 proteins in human or mouse</td> </tr> <tr> <td><a href="/products/human-mag-luminex-performance-assay-base-kit-angio-panel-a_lanm000" target="_blank">Luminex<sup>®</sup> Angiogenesis Panel</a><br />     Highly validated, accurate, and precise multianalyte profiling</td> </tr> <tr> <td><a href="https://www.proteinsimple.com/ella.html" target="_blank">Simple Plex<sup>™</sup> Assays</a> (at proteinsimple.com)<br />     Automated quantitation of cytokine secretion profiles in <1 hour</td> </tr> <tr> <td><a href="/products/angiogenesis-assays" target="_blank">Angiogenesis Assays</a></td> </tr> <tr> <td><a href="/search?keywords=ve-cadherin%20or%20cd31%20or%20lyve*%20or%20e-selectin%20or%20%22vegf%20r*%22&numResults=50&category=Primary%20Antibodies&rnd_applications=Immunohistochemistry" target="_blank">IHC Antibodies for Vascular Endothelium</a></td> </tr> </tbody> </table> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading" id="hosttissueresponse2" role="tab"> <h3 class="panel-title"><a aria-controls="hosttissueresponseTwo" aria-expanded="true" data-parent="#hosttissueresponse2" data-toggle="collapse" href="#hosttissueresponseTwo" role="button">Products for Regulating and Modulating Extracellular Matrix Formation</a></h3> </div> <div aria-expanded="true" aria-labelledby="hosttissueresponse2" class="panel-collapse collapse" id="hosttissueresponseTwo" role="tabpanel" style=""> <div class="panel-body"> <table cellpadding="0" cellspacing="0" width="100%"> <tbody> <tr> <td><a href="/search?keywords=proteoglycan%20or%20collagen*%20or%20chitinase*%20or%20fibronectin%20or%20fibulin*%20or%20laminin*%20or%20matrilin*%20or%20thrombospondin*&numResults=50&category=Primary%20Antibodies&rnd_applications=Immunohistochemistry" target="_blank">IHC Antibodies for Components</a></td> </tr> <tr> <td><a href="/research-area/extracellular-matrix-molecules" target="_blank">Extracellular Matrix Molecules</a></td> </tr> <tr> <td><a href="/research-area/proteoglycans" target="_blank">Proteoglycans</a></td> </tr> <tr> <td><a href="/research-area/glycobiology-assay-kits-and-reagents" target="_blank">Glycobiology Assay Kits and Reagents</a></td> </tr> </tbody> </table> </div> </div> </div> <div class="panel panel-default"> <div class="panel-heading" id="hosttissueresponse3" role="tab"> <h3 class="panel-title"><a aria-controls="hosttissueresponseThree" aria-expanded="true" data-parent="#hosttissueresponse3" data-toggle="collapse" href="#hosttissueresponseThree" role="button">Apoptosis Assays and Reagents</a></h3> </div> <div aria-expanded="true" aria-labelledby="hosttissueresponse3" class="panel-collapse collapse" id="hosttissueresponseThree" role="tabpanel" style=""> <div class="panel-body"> <table cellpadding="0" cellspacing="0" width="100%"> <tbody> <tr> <td><a href="/products/cell-proliferation-and-viability" target="_blank">Cell Proliferation and Viability Assays</a></td> </tr> <tr> <td><a href="/products/apoptosis-detection-kits-reagents" target="_blank">Apoptosis Detection Kits and Reagents</a></td> </tr> <tr> <td><a href="/products/dna-damage-and-repair-kits-reagents" target="_blank">DNA Damage and Repair Kits and Reagents</a></td> </tr> <tr> <td><a href="https://www.tocris.com/search?keywords=apoptosis&target_facet=Apoptosis%20Inducers&numResults=30&utm_source=rndsystems&utm_medium=referral&utm_campaign=Cell%20and%20Gene%20Therapy&utm_term=efficacy%20and%20toxicity&utm_content=apoptosis%20inducer%20compounds%20-%20apoptosis" target="_blank">Apoptosis Inducer Compounds</a> (at tocris.com)</td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> </div> </div> <div> </div> <div class="row"> <div class="container"> <div class="quality col-xs-12 col-sm-2"><img alt="Custom Services" class="image-responsive" 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