CINXE.COM

<!DOCTYPE html> <html> <head> <meta charset="UTF-8"><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:[]},session_replay:{sampling_rate:10.0,mask_text_selector:"",block_selector:"",mask_input_options:{date:true,text_area:true,week:true,select:true,color:true,range:true,textarea:true,url:true,number:true,search:true,month:true,datetime_local:true,tel:true,text:true,time:true,email:true},enabled:true,error_sampling_rate:100.0}};(window.NREUM||(NREUM={})).loader_config={xpid:"UA8FUVBADwsIV1VaAgQD",licenseKey:"76fb58fb05",applicationID:"788348554"};;/*! For license information please see nr-loader-full-1.281.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>g,gD:()=>m,xN:()=>p});var n=r(3333),i=r(993);const o=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var a=r(2614),s=r(944),c=r(384),u=r(8122);const d="[data-nr-mask]",l=()=>{const e={feature_flags:[],experimental:{marks:!1,measures:!1,resources:!1},mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},get feature_flags(){return e.feature_flags},set feature_flags(t){e.feature_flags=t},generic_events:{enabled:!0,autoStart:!0},harvest:{interval:30},jserrors:{enabled:!0,autoStart:!0},logging:{enabled:!0,autoStart:!0,level:i.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,autoStart:!0},performance:{get capture_marks(){return e.feature_flags.includes(n.$v.MARKS)||e.experimental.marks},set capture_marks(t){e.experimental.marks=t},get capture_measures(){return e.feature_flags.includes(n.$v.MEASURES)||e.experimental.measures},set capture_measures(t){e.experimental.measures=t},capture_detail:!0,resources:{get enabled(){return e.feature_flags.includes(n.$v.RESOURCES)||e.experimental.resources},set enabled(t){e.experimental.resources=t},asset_types:[],first_party_domains:[],ignore_newrelic:!0}},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:a.wk,inactiveMs:a.BB},session_replay:{autoStart:!0,enabled:!1,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){o(t)?e.mask_selector="".concat(t,",").concat(d):""===t||null===t?e.mask_selector=d:(0,s.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){o(t)?e.block_selector+=",".concat(t):""!==t&&(0,s.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,s.R)(7,t)}},session_trace:{enabled:!0,autoStart:!0},soft_navigations:{enabled:!0,autoStart:!0},spa:{enabled:!0,autoStart:!0},ssl:void 0,user_actions:{enabled:!0,elementAttributes:["id","className","tagName","type"]}}},f={},h="All configuration objects require an agent identifier!";function g(e){if(!e)throw new Error(h);if(!f[e])throw new Error("Configuration for ".concat(e," was never set"));return f[e]}function p(e,t){if(!e)throw new Error(h);f[e]=(0,u.a)(t,l());const r=(0,c.nY)(e);r&&(r.init=f[e])}function m(e,t){if(!e)throw new Error(h);var r=g(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0,harvester:void 0},d={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!d[e])throw new Error("Runtime for ".concat(e," was never set"));return d[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");d[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(d[e],"harvestCount")||Object.defineProperty(d[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=d[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.281.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{OF:()=>u,RI:()=>i,WN:()=>f,bv:()=>o,gm:()=>a,lR:()=>l,m:()=>c,mw:()=>s,sb:()=>d});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s=Boolean("hidden"===a?.document?.visibilityState),c=""+a?.location,u=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),d=u&&"undefined"==typeof SharedWorker,l=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),f=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>u});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};d(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function d(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(d(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)g(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function g(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},d={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:g,addEventListener:g,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=p(e),d=c.length,l=0;l<d;l++)c[l].apply(a,r);var g=v()[s[e]];g&&g.push([f,e,r,a]);return a},get:m,listeners:p,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function g(e,t){n[e]=p(e).concat(t)}function p(e){return n[e]||[]}function m(t){return d[t]=d[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),d=(0,n.Zm)();d.ee||(d.ee=u)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>u});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function u(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>d,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function d(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,u="addEventListener",d="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[u,d],"-",g)}function g(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),c&&h(c.prototype,f),h(a.gm,f)),t.on(u+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(d+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,u);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],d,c),e}finally{i(r+"end",[o,a,l],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{$v:()=>u,TZ:()=>n,Zp:()=>i,kd:()=>c,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3,c=["PageAction","UserAction","BrowserPerformance"],u={MARKS:"experimental.marks",MEASURES:"experimental.measures",RESOURCES:"experimental.resources"}},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>u});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function u(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>d,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>u,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},u={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},d=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>u,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function u(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>u,Rz:()=>d,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState",l=1e3},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>j});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),u=r(5289),d=r(6154),l=r(944),f=r(3969),h=r(384),g=r(6344);const p=["setErrorHandler","finished","addToTrace","addRelease","recordCustomEvent","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",g.G4.RECORD,g.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),R=r(3785),x=r(2646),w=r(3434);const E=new Map;function A(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,w.YM)(i),a=new x.y(s.P);a.level=n.level,a.customAttributes=n.customAttributes;const c=t[r]?.[w.Jt]||t[r];return E.set(c,a),o.inPlace(t,[r],"wrap-logger-",(()=>E.get(c))),i}function T(){const e=(0,h.pV)();p.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const _={};var S=r(9417),O=r(5603),N=r(5284);const I=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let P=!1;function j(e,t={},p,x){let{init:w,info:E,loader_config:j,runtime:C={},exposed:k=!0}=t;C.loaderType=p;const H=(0,h.pV)();E||(w=H.init,E=H.info,j=H.loader_config),(0,S.xN)(e.agentIdentifier,w||{}),(0,O.a)(e.agentIdentifier,j||{}),E.jsAttributes??={},d.bv&&(E.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,E);const L=(0,S.D0)(e.agentIdentifier),D=[E.beacon,E.errorBeacon];P||(L.proxy.assets&&(I(L.proxy.assets),D.push(L.proxy.assets)),L.proxy.beacon&&D.push(L.proxy.beacon),T(),(0,h.US)("activatedFeatures",N.B),e.runSoftNavOverSpa&&=!0===L.soft_navigations.enabled&&L.feature_flags.includes("soft_nav")),C.denyList=[...L.ajax.deny_list||[],...L.ajax.block_internal?D:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const p={};var x=s.ee.get(e),w=x.get("tracer");_[e]=b.g.OFF,x.on(g.G4.REPLAY_RUNNING,(t=>{_[e]=t}));var E="api-",T=E+"ixn-";function S(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(E,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}p.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,x),(0,R.R)(x,e,t,r)},p.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,x),A(x,e,t,{customAttributes:r,level:i})},m.forEach((e=>{p[e]=I(E,e,!0,"api")})),p.addPageAction=I(E,"addPageAction",!0,n.K7.genericEvents),p.recordCustomEvent=I(E,"recordCustomEvent",!0,n.K7.genericEvents),p.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(E,"setPageViewName",!0)()},p.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return S(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},p.setUserId=function(e){if("string"==typeof e||null===e)return S("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},p.setApplicationVersion=function(e){if("string"==typeof e||null===e)return S("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},p.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,x),x.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},p[g.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.RECORD,[],void 0,n.K7.sessionReplay,x)},p[g.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.PAUSE,[],void 0,n.K7.sessionReplay,x)},p.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const N=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,x),h||(0,a.p)(T+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,x),function(){if(w.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw w.emit("fn-err",[arguments,this,t],r),t}finally{w.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,x),i&&(0,a.p)(e+t,[r?(0,v.t)():performance.now(),...arguments],r?null:this,i,x),r?void 0:this}}function P(){r.e(891).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),x.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{N[e]=I(T,e,void 0,h?n.K7.softNav:n.K7.spa)})),p.setCurrentRouteName=h?I(T,"routeName",void 0,n.K7.softNav):I(E,"routeName",!0,n.K7.spa),p.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,x),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!_[e]],void 0,n.K7.jserrors,x)},d.RI?(0,u.GG)((()=>P()),!0):P(),p}(e.agentIdentifier,x,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),P=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>u,K7:()=>s,P3:()=>c,XX:()=>i,qY:()=>n,v4:()=>a});const n="events",i="jserrors",o="browser/blobs",a="rum",s={ajax:"ajax",genericEvents:"generic_events",jserrors:i,logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},c={[s.pageViewEvent]:1,[s.pageViewTiming]:2,[s.metrics]:3,[s.jserrors]:4,[s.spa]:5,[s.ajax]:6,[s.sessionTrace]:7,[s.softNav]:8,[s.sessionReplay]:9,[s.logging]:10,[s.genericEvents]:11},u={[s.pageViewEvent]:a,[s.pageViewTiming]:n,[s.ajax]:n,[s.spa]:n,[s.softNav]:n,[s.metrics]:i,[s.jserrors]:i,[s.sessionTrace]:o,[s.sessionReplay]:o,[s.logging]:"browser/logs",[s.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({95:"nr-full-compressor",222:"nr-full-recorder",891:"nr-full"}[e]+"-1.281.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.281.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={891:"sha512-54Aat8Udm6iAAlMAdj4qB/wPExKn9TKWSsPnD5+K2RMckmHE0cb0CFc0VauDfpPug5wse9qzwDKuwIMa3hX6gw==",222:"sha512-IA751FH/bvhLWl8I5ZELgH0tFQetWKV1G+9qRkPvOrTSv2X2tgItmreKfvrd8zImHp4sIPTnSN0otmgnX7UJXA==",95:"sha512-Rwnn8hCtQVvDGDl0hSpEazVuRDuvlGnJpNuNwuapJ46vDCvUNGBIzCZCrZYygTgVJUjMrfQoMAULb+2gKoTIiQ=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(g);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},g=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={85:0,959:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.281.0.PROD"]=self["webpackChunk:NRBA-1.281.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(){this.agentIdentifier=(0,r.LA)(16)}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}recordCustomEvent(e,t){return this.#e("recordCustomEvent",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var d=i(425);var l=i(1687),f=i(4234),h=i(5289),g=i(6154),p=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(891).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(891).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),t.runtime.harvester.initializedAggregates.push(this.featAggregate),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};g.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,p.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class R extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var x=i(384);var w=i(9908),E=i(2843),A=i(3878),T=i(782),_=i(1863);class S extends b{static featureName=T.T;constructor(e,t=!0){super(e,T.T,t),g.RI&&((0,E.u)((()=>(0,w.p)("docHidden",[(0,_.t)()],void 0,T.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,w.p)("winPagehide",[(0,_.t)()],void 0,T.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class N extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),P=i(3304);class j{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,P.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return L(e)?e:new j(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(L(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function H(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new j(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return L(e.error)?e.error:C(e)}function L(e){return e instanceof Error&&!!e.stack}class D extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",((e,t)=>{this.abortHandler&&(0,w.p)("ierr",[C(e),(0,_.t)(),!0,{},this.#r,t],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),g.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,w.p)("err",[k(e),(0,_.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),g.gm.addEventListener("error",(e=>{this.abortHandler&&(0,w.p)("err",[H(e),(0,_.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var M=i(8990);let K=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===g.gm?0:(0,M.I)(e,U,(function(){return K++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,P.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(void 0===g.gm.XMLHttpRequest)return n;if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=g.gm.XMLHttpRequest,a=g.gm.MutationObserver,s=g.gm.Promise,c=g.gm.setInterval,u="readystatechange",d=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=g.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(u,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,d,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(p?p.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var p=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===u||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",J=["arrayBuffer","blob","json","text","formData"],Q=g.gm.Request,ee=g.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(Q&&ee&&g.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,J.forEach((e=>{r(Q[te],e,X),r(ee[te],e,X)})),r(g.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof g.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,P.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),ue=["load","error","abort","timeout"],de=ue.length,le=(0,x.dV)().o.REQ,fe=(0,x.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,w.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};g.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};ge(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=x,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){E(t,e)}),(0,A.jT)(!1)),g.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},ge(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,_.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<de;s++)r.addEventListener(ue[s],this.listener,(0,A.jT)(!1))}function u(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function d(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,_.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function p(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,_.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,_.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&g.RI&&(t=""+g.gm.location.href):e[0]&&e[0].url?t=e[0].url:g.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,_.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:g.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),ge(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function R(e,t){if(this.endTime=(0,_.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,_.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function x(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<de;t++)e.removeEventListener(ue[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,_.t)()-this.startTime,this.loadCaptureCalled||4!==e.readyState?null==t.status&&(t.status=0):E(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function E(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,w.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",u),t.on("xhr-load-added",d),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",p),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",R)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function ge(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const pe={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!g.RI||pe[t.debugId]++||(pe[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:Re,d3:xe,Kp:we,TZ:Ee,Lc:Ae,uP:Te,Rz:_e}=be;class Se extends b{static featureName=Ee;constructor(e,t=!0){super(e,Ee,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Te,(function(e,t){this.bstStart=(0,_.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,w.p)("bst",[e[0],t,this.bstStart,(0,_.t)()],void 0,a.K7.sessionTrace,r)})),r.on(_e+xe,(function(e){this.time=(0,_.t)(),this.startPath=location.pathname+location.hash})),r.on(_e+we,(function(e){(0,w.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,w.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:Re,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class Ne extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,p.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,w.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,p.Aw)(this.agentIdentifier)}#u=!1;async#c(e){if(!this.#u){this.#u=!0;try{const{Recorder:t}=await Promise.all([i.e(891),i.e(222)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee,agentRef:this.#o}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3333);class Pe extends b{static featureName=Ie.TZ;constructor(e,t=!0){super(e,Ie.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled,e.init.performance.resources.enabled];if(g.RI&&(e.init.user_actions.enabled&&(Ie.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,w.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),Ie.qN.forEach((e=>{const t=(0,v.s)((e=>{(0,w.p)("ua",[e],void 0,this.featureName,this.ee)}),500,{leading:!0});(0,A.sp)(e,t)}))),e.init.performance.resources.enabled&&g.gm.PerformanceObserver?.supportedEntryTypes.includes("resource"))){new PerformanceObserver((e=>{e.getEntries().forEach((e=>{(0,w.p)("browserPerformance.resource",[e],void 0,this.featureName,this.ee)}))})).observe({type:"resource",buffered:!0})}r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var je=i(993),Ce=i(3785);class ke extends b{static featureName=je.TZ;constructor(e,t=!0){super(e,je.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,Ce.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t){super(),g.gm?(this.features={},(0,x.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(R),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,d.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,x.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,S,Se,Ne,he,N,D,Pe,ke],loaderType:"pro"})})()})();</script> <meta name="keywords" content="" /> <link rel="canonical" href="https://www.bio-techne.com/research-areas/exosomes" /> <meta name="baidu-site-verification" content="xQr2vSIwwB" /> <title>Exosomes Research</title> <meta name="description" content="Global antibody supplier and research reagent supplier to the life science community. Find antibodies and reagents all backed by our Guarantee+." /> <meta name="pubDate" content="201608" /> <script id="json-ld" type="application/ld+json">[{"@context":"http://schema.org","@type":"SiteNavigationElement","about":[{"@type":"Thing","url":"/support/sars-cov-research-resources","name":"COVID-19 Research Tools"},{"@type":"Thing","url":"/productsearch/novus","name":"Antibodies"},{"@type":"Thing","url":"/products/primary-antibodies","name":"Primary Antibodies"},{"@type":"Thing","url":"/conjugatedantibodies.html","name":"Conjugated Antibodies"},{"@type":"Thing","url":"/samplesize","name":"Sample Size Antibodies"},{"@type":"Thing","url":"/products/crispr-cas9-genetic-knockout-antibody-validation-reproducibility","name":"KO Validated Antibodies"},{"@type":"Thing","url":"https://www.novusbio.com/recombinant-monoclonals","name":"Recombinant Antibodies"},{"@type":"Thing","url":"/product-type/antibody-packs","name":"Antibody Sampler Packs"},{"@type":"Thing","url":"/product-type/antibody-pairs","name":"Antibody Pairs"},{"@type":"Thing","url":"/support/GeneralSecondaryAntibodies","name":"Secondary Antibodies"},{"@type":"Thing","url":"/products/isotype-controls","name":"Isotype Control Antibodies"},{"@type":"Thing","url":"/product-type/peptides-and-proteins","name":"Proteins and Peptides"},{"@type":"Thing","url":"/products/peptides-and-proteins","name":"Peptides & Proteins"},{"@type":"Thing","url":"/support/blocking-with-immunizing-peptide","name":"Blocking Peptides"},{"@type":"Thing","url":"/product-type/peptides-and-proteins%3Fapplications%3DBioactivity","name":"Biologically Active Proteins"},{"@type":"Thing","url":"https://www.novusbio.com/product-type/lysates","name":"Lysates and Cell Lines"},{"@type":"Thing","url":"/product-type/lysates","name":"Lysates"},{"@type":"Thing","url":"/research-areas/stem-cells/stem-cell-lines.html","name":"Stem Cell Lines"},{"@type":"Thing","url":"/product-type/kits","name":"Kits"},{"@type":"Thing","url":"/Lightning-Link%20Antibody%20Labeling%20Kits","name":"Antibody Labeling Kits"},{"@type":"Thing","url":"/product-type/kits%3Fcategory%3DKits%26kit_type%3DChIP%2520Kit","name":"ChIP Kits"},{"@type":"Thing","url":"/products/elisa-kits","name":"ELISA Kits"},{"@type":"Thing","url":"/product-type/kits%3Fcategory%3DKits%26kit_type%3DFlow%2520Cytometry%2520Kit","name":"Flow Cytometry Kits"},{"@type":"Thing","url":"/product-type/support-products%3Fcategory%3DSupport%2520Products%26applications%3DLigand%2520Activation","name":"Activators and Inhibitors"},{"@type":"Thing","url":"/product-type/inhibitors","name":"Inhibitors"},{"@type":"Thing","url":"/product-type/support-products%3Fcategory%3DSupport%2520Products%26applications%3DLigand%2520Activation","name":"Activators"},{"@type":"Thing","url":"/product-type/support-products","name":"Support Products"},{"@type":"Thing","url":"/research-topics/cell-biology/exosome-isolation-and-detection","name":"Exosome Isolation"},{"@type":"Thing","url":"/products/flow-cytometry-quality-control-beads","name":"Flow Cytometry Beads"},{"@type":"Thing","url":"/control-slides","name":"IHC Tissue Slides"},{"@type":"Thing","url":"/tissue-microarrays","name":"IHC Microarrays"},{"@type":"Thing","url":"/search%3Fkeywords%3Drunblue","name":"Western Blot Gels & Buffers"},{"@type":"Thing","url":"/product-type/wb-membranes","name":"Western Blot Membranes"},{"@type":"Thing","url":"/product-type/support-products","name":"All Support Products"},{"@type":"Thing","url":"/support/bulk-and-custom.html","name":"Bulk and Custom"},{"@type":"Thing","url":"/support.html","name":"Resources"},{"@type":"Thing","url":"/support/support-by-application.html","name":"Protocols"},{"@type":"Thing","url":"/support/video-protocols","name":"Video Protocols"},{"@type":"Thing","url":"/support/troubleshooting","name":"Troubleshooting Guides"},{"@type":"Thing","url":"/mailing-list","name":"Posters and Literature"},{"@type":"Thing","url":"/support/handbooks-and-guides","name":"Handbooks and Guides"},{"@type":"Thing","url":"/resources/calculators","name":"Calculators"},{"@type":"Thing","url":"/support/faqs.html","name":"FAQs"},{"@type":"Thing","url":"/antibody-news","name":"Blogs"},{"@type":"Thing","url":"/all-diseases.html","name":"Diseases"},{"@type":"Thing","url":"/whitepapers.html","name":"Whitepapers"},{"@type":"Thing","url":"/webform/help-finding-antibodies","name":"Antibody Concierge"},{"@type":"Thing","url":"/webinar","name":"Webinars"},{"@type":"Thing","url":"/research-tools.html","name":"Tools"},{"@type":"Thing","url":"/spectraviewer","name":"Spectra Viewer"},{"@type":"Thing","url":"/novusknowsflow.html","name":"Flow Cytometry Panel Builder"},{"@type":"Thing","url":"/application","name":"Application"},{"@type":"Thing","url":"/application/elisa","name":"ELISA"},{"@type":"Thing","url":"/application/flow-cytometry","name":"Flow Cytometry"},{"@type":"Thing","url":"https://www.novusbio.com/products/antibodies-cytof","name":"Mass Cytometry (CyTOF)"},{"@type":"Thing","url":"/application/icc","name":"ICC"},{"@type":"Thing","url":"/application/ihc","name":"IHC"},{"@type":"Thing","url":"/application/western-blotting","name":"Western Blotting"},{"@type":"Thing","url":"/interviews","name":"Interviews"},{"@type":"Thing","url":"/faculty/faculty-interviews","name":"Faculty"},{"@type":"Thing","url":"/postdoc/postdoc-interviews","name":"Postdoc"},{"@type":"Thing","url":"/research-areas.html","name":"By Research Area"},{"@type":"Thing","url":"/apoptosis-pathway","name":"Apoptosis"},{"@type":"Thing","url":"/autophagy-pathway","name":"Autophagy"},{"@type":"Thing","url":"/research-areas/cancer","name":"Cancer"},{"@type":"Thing","url":"/research-areas/cell-biology","name":"Cell Biology"},{"@type":"Thing","url":"/research-areas/cellular-markers","name":"Cellular Markers"},{"@type":"Thing","url":"/research-areas/epigenetics","name":"Epigenetics"},{"@type":"Thing","url":"/research-areas/epitope-tags","name":"Epitope Tags"},{"@type":"Thing","url":"/research-areas/cell-biology/Exosome-research-tools","name":"Exosomes Research"},{"@type":"Thing","url":"/research-areas/hypoxia","name":"Hypoxia"},{"@type":"Thing","url":"/research-areas/immunology","name":"Immunology"},{"@type":"Thing","url":"/research-areas/microbiology","name":"Microbiology"},{"@type":"Thing","url":"/research-areas/neuroscience","name":"Neuroscience"},{"@type":"Thing","url":"/research-areas/stem-cells","name":"Stem Cells"},{"@type":"Thing","url":"/pathwaypages.html","name":"By Pathway"},{"@type":"Thing","url":"/akt-signaling-pathway","name":"AKT "},{"@type":"Thing","url":"/mapkerkpathway.html","name":"ERK1/2/5 Pathway"},{"@type":"Thing","url":"/hedgehogpathway.html","name":"Hedgehog"},{"@type":"Thing","url":"/hippo-pathway.html","name":"Hippo"},{"@type":"Thing","url":"/jnk-signaling-pathway","name":"JNK Pathway"},{"@type":"Thing","url":"/mtor-pathway","name":"mTOR"},{"@type":"Thing","url":"/necroptosis-pathway","name":"Necroptosis"},{"@type":"Thing","url":"/nfkbpathway","name":"NFKB Signaling"},{"@type":"Thing","url":"/p38mapkpathway.html","name":"p38 Signaling"},{"@type":"Thing","url":"/tgfbetapathway","name":"TGF Beta"},{"@type":"Thing","url":"/toll-like-receptors","name":"TLR"},{"@type":"Thing","url":"/programs.html","name":"Customer Care"},{"@type":"Thing","url":"/guarantee","name":"100% Guarantee"},{"@type":"Thing","url":"/support/innovators-reward.html","name":"Risk Free Testing"},{"@type":"Thing","url":"/about/rewards.html","name":"Novus Rewards Program"},{"@type":"Thing","url":"/publications","name":"Publication Rewards Program"},{"@type":"Thing","url":"/newlab.html","name":"New Lab Discount"},{"@type":"Thing","url":"/scholarship-program.html","name":"Scholarship"},{"@type":"Thing","url":"/travelgrant.html","name":"Travel Grants"},{"@type":"Thing","url":"/products/promotions","name":"Promotions"},{"@type":"Thing","url":"/about.html","name":"About us"},{"@type":"Thing","url":"https://www.bio-techne.com/about/careers","name":"Careers"},{"@type":"Thing","url":"/about/collaborations.html","name":"Collaborations"},{"@type":"Thing","url":"/about/events","name":"Events"},{"@type":"Thing","url":"/about/novus-story.html","name":"Novus Story"},{"@type":"Thing","url":"/about/novus-team.html","name":"Our Team"},{"@type":"Thing","url":"/about/novus-philanthropy.html","name":"Philanthropy"},{"@type":"Thing","url":"/about/press-release.html","name":"Press Releases"},{"@type":"Thing","url":"/why-choose-novus.html","name":"Why choose Novus"},{"@type":"Thing","url":"/about/contact-us.html","name":"Contact Us"},{"@type":"Thing","url":"/about/contact-us.html","name":"Customer Service"},{"@type":"Thing","url":"/novus-distributors/list","name":"Distributors"},{"@type":"Thing","url":"/support/technical-support.html","name":"Technical Support"}]},{"@context":"http://schema.org","@type":"WPFooter","about":[{"@type":"Thing","url":"https://www.novusbio.com/productsearch/novus","name":"Antibodies"},{"@type":"Thing","url":"https://www.novusbio.com/product-type/secondary-antibodies","name":"Secondary Antibodies"},{"@type":"Thing","url":"https://www.novusbio.com/product-type/isotype-controls","name":"Isotype Controls"},{"@type":"Thing","url":"https://www.novusbio.com/product-type/peptides-and-proteins","name":"Proteins and Peptides"},{"@type":"Thing","url":"https://www.novusbio.com/product-type/elisa-kits","name":"ELISA Kits"},{"@type":"Thing","url":"https://www.novusbio.com/samplesize","name":"Sample Size"},{"@type":"Thing","url":"https://www.novusbio.comhttps://www.novusbio.com/new-product-information-page.html","name":"New Products"},{"@type":"Thing","url":"https://www.novusbio.com/about.html","name":"About Us"},{"@type":"Thing","url":"https://www.novusbio.comhttps://www.bio-techne.com/about/careers","name":"Careers"},{"@type":"Thing","url":"https://www.novusbio.com/guarantee","name":"Novus Guarantee"},{"@type":"Thing","url":"https://www.novusbio.com/about/contact-us.html","name":"Contact Us"},{"@type":"Thing","url":"https://www.novusbio.com/about/novus-team.html","name":"Our Team"},{"@type":"Thing","url":"https://www.novusbio.com/support/customer-service/privacy-policy.html","name":"Privacy Policy"},{"@type":"Thing","url":"https://www.novusbio.com/novus-bio-sitemap.html","name":"Sitemap"},{"@type":"Thing","url":"https://www.novusbio.com/about/contact-us.html","name":"Contact Us"},{"@type":"Thing","url":"https://www.novusbio.com/support/customer-service/terms.html","name":"Terms & Conditions"},{"@type":"Thing","url":"https://www.novusbio.com/support/technical-support.html","name":"Technical Support"},{"@type":"Thing","url":"https://www.novusbio.com/support/faqs.html","name":"FAQs"},{"@type":"Thing","url":"https://www.novusbio.com/webform/help-finding-antibodies","name":"Help Finding Antibodies"},{"@type":"Thing","url":"https://www.novusbio.com/support/support-by-application.html","name":"Protocols"}]},{"@context":"http://schema.org","@type":"WebPage","breadcrumb":{"@context":"http://schema.org","@type":"BreadcrumbList","itemListElement":[{"@context":"http://schema.org","@type":"ListItem","position":1,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.novusbio.com/","name":"Home"}},{"@context":"http://schema.org","@type":"ListItem","position":2,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.novusbio.com/research-areas.html","name":"By Research Area"}}]},"potentialaction":{"query":""}}]</script> <meta name="generator" content="Drupal 7 (https://www.drupal.org)" /> <link rel="shortlink" href="https://www.novusbio.com/node/12415696" /> <meta property="og:site_name" content="Novus Biologicals" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.novusbio.com/research-areas/cell-biology/Exosome-research-tools" /> <meta property="og:title" content="Exosomes Research" /> <meta property="og:image" content="https://resources.bio-techne.com/images/Social/2019NovusLogo.png" /> <link type="text/css" rel="stylesheet" href="https://www.novusbio.com/sites/novusbio.com/files/css/css_LyQQziAp-Ie-zmhrx1RDdqrlziy3o8gvzDqRXCb00hg.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://www.novusbio.com/sites/novusbio.com/files/css/css_epQTvxkLlfWLGSq94lW04RlDEK26840QgzyS2d_R_fw.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://www.novusbio.com/sites/novusbio.com/files/css/css_tNmOxVEosy2l9wZ6MEr2is7YS4DOk4IaAhI_iyRMDLw.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://www.novusbio.com/sites/novusbio.com/files/css/css_8-zvMULc0G5JczOUIWkZin0svexCP7R5pWo6msP_YwM.css" media="all" /> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_VUlliwzd-_is1_ryJskaiFlvPtaBpYuWsDxU6fMyUEk.js"></script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_c8LbWbHV1txem3q8oAzuadnL-HiBShaQH_WRviNqT_g.js"></script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_4newT8cBOK9auTS1LAR6RL1VYq1INsyOKwxSb1E2BPI.js"></script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_L8lyw9KaYYTt-8qh-mBY7lce378ekr1ZVaQi2f0q5pI.js"></script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_4Vv8GAuPg4M6GWetVxgFDPNPYfVcP37nnmzoZnsPOj8.js"></script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_V5Fwoup1DkxxL-Rm-7is5QWj_MZhigWTY27_fmKn7S4.js"></script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_Cd-6G9n7MZHe1pMqkZXBsw7rJDf_w3XQZBszSMZjV5s.js"></script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_MrgubHtdOA1nVcjDTR4s-m0ya_aIvugR02VlGxCGGDw.js"></script> <script type="text/javascript" src="https://www.novusbio.com/sites/novusbio.com/files/js/js_sNIdssRhxhJxJxAR2Pduc4_PqOXIKZf2m8g4hyLSJ8s.js"></script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <link rel="shortcut icon" type="image/ico" href="//images.novusbio.com/design/faviconNew.ico"/> <meta name="yandex-verification" content="e7c24419f013b549"/> </head> <body class="html not-front not-logged-in no-sidebars page-node page-node- page-node-12415696 node-type-page" >  <noscript> <iframe src="https://www.googletagmanager.com/ns.html?id=GTM-52KXLL" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript>  <div id="skip-link"> <a href="#main-content" class="element-invisible element-focusable">Skip to main content</a> </div> <noscript aria-hidden="true"><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-52KXLL" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div class="region region-bt-brands-bar"> <div id="block-bt-brands-bar-bt-brands-bar" class="block block-bt-brands-bar"> <div class="content"> <div id="bt_brands_bar"> <div class="container_16"> <div style="margin-left: 0px; margin-right: 0px; width:960px;zoom:1;word-wrap:break-word;"> <ul> <li><a href="https://www.bio-techne.com" rel="noopener noreferrer" target="_blank" aria-label="Bio-Techne"><div class="brandsSprite_biotechne"></div></a></li><li><a href="https://www.rndsystems.com" rel="noopener noreferrer" target="_blank" aria-label="R&D Systems"><div class="brandsSprite_rndsystems"></div></a></li><li class="active"><div class="brandsSprite_novusbio_color"></div></li><li><a href="https://www.tocris.com" rel="noopener noreferrer" target="_blank" aria-label="Tocris Bioscience"><div class="brandsSprite_tocris"></div></a></li><li><a href="https://www.bio-techne.com/brands/proteinsimple" rel="noopener noreferrer" target="_blank" aria-label="ProteinSimple"><div class="brandsSprite_proteinsimple"></div></a></li><li><a href="https://www.biospacific.com" rel="noopener noreferrer" target="_blank" aria-label="BiosPacific"><div class="brandsSprite_biospacific"></div></a></li><li><a href="https://www.cliniqa.com" rel="noopener noreferrer" target="_blank" aria-label="Cliniqa"><div class="brandsSprite_cliniqa"></div></a></li><li><a href="https://acdbio.com/ " rel="noopener noreferrer" target="_blank" aria-label="ACD"><div class="brandsSprite_acd"></div></a></li><li><a href="https://www.rndheme.com" rel="noopener noreferrer" target="_blank" aria-label="R&D Heme"><div class="brandsSprite_rndheme"></div></a></li> </ul> </div> </div> </div> </div> </div> <div id="block-et-cookie-policy-cookie-policy" class="block block-et-cookie-policy"> <div class="content"> <div></div> </div> </div> </div> <div class="overlay"></div> <div id="header"> <div class="bluewide_wrapper"> <div class="container_16"> <div class="grid_16"> <div id="top_bar"> <div class="region region-top-left-bar"> <div id="block-et-internationalization-novus-dist-short" class="block block-et-internationalization"> <div class="content"> <div id="top_bar_support_info"><noscript>Support: 1-888-506-6887</noscript></div> </div> </div> </div> <div id="top_bar_novus"> <div class="region region-top-right-bar"> <div id="block-et-quickorder-et-quickorder" class="block block-et-quickorder"> <div class="content"> <div id="quickOrder_topbar">Quick Order  <div class="fp_quickorder_arrow"></div> <div id="quickOrder_dropdown"> <p class="quickOrder_disabled">Quick order is disabled in your country. Please contact Customer Service if you have questions.</p></div> </div> </div> </div> <div id="block-et-internationalization-country-dropdown" class="block block-et-internationalization"> <div class="content"> <div id="internationalization_country_select"> <div class="internationalization_drop"></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="content-wrapper" class="container_16"> <div class="grid_4"> <div id="logo"> <a href="/"><img src="//images.novusbio.com/design/novus_color_RGB_small.png" alt="Novus Biologicals Logo"></a> </div> </div> <div class="grid_12"> <div class="region region-login-area"> <div id="block-et-internationalization-sign-in" class="block block-et-internationalization"> <div class="content"> <div id="sign_in"><a href="/user/login" rel="nofollow"><noscript>Account</noscript></a></div> </div> </div> </div> <div class="search_form_container"> <div class="region region-search-bar"> <div id="block-et-searchbar-et-searchbar-bar" class="block block-et-searchbar"> <div class="content"> <div class="et_searchbar_wrapper"> <form name="et_searchbar" method="GET" action="/search" class="search_form"><div class="et_searchbar"> <input autocomplete="off" name="keywords" type="text" class="et_searchbar_wide et_searchbar_default" value="" placeholder="Enter Catalog #, Protein, or Keywords." data-default="" /><input type="submit" value="search" class="fp_mag_glass_wideSearch"></div></form><div class="et_spinner_small et_searchbar_spinner"></div> </div> </div> </div> </div>  </div> </div> <div class="clear"></div> </div> </div> <div class="bluewide_wrapper"> <div class="container_16"> <div class="grid_16" id="main_menu"> <div class="region region-header"> <div id="block-et-main-menu-et-main-menu-block" class="block block-et-main-menu"> <div class="content"> <div id="main_menu_wrapper"> <ul id="small_menu"> <li class="main_menu_parent"> <div class="main_menu_submenu"><div id="menu_products" class="menu_drop"> <div class="mm_menu"><ul class="menu"><li class="first expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first leaf"><a href="/support/sars-cov-research-resources" title="">COVID-19 Research Tools</a></li> <li class="expanded"><a href="/productsearch/novus" title="">Antibodies</a><ul class="menu"><li class="first expanded"><a href="/products/primary-antibodies" title="">Primary Antibodies</a><ul class="menu"><li class="first leaf"><a href="/conjugatedantibodies.html" title="">Conjugated Antibodies</a></li> <li class="leaf"><a href="/samplesize" title="">Sample Size Antibodies</a></li> <li class="leaf"><a href="/products/crispr-cas9-genetic-knockout-antibody-validation-reproducibility" title="">KO Validated Antibodies</a></li> <li class="leaf"><a href="https://www.novusbio.com/recombinant-monoclonals" title="">Recombinant Antibodies</a></li> <li class="leaf"><a href="/product-type/antibody-packs" title="">Antibody Sampler Packs</a></li> <li class="last leaf"><a href="/product-type/antibody-pairs" title="">Antibody Pairs</a></li> </ul></li> <li class="leaf"><a href="/support/GeneralSecondaryAntibodies" title="">Secondary Antibodies</a></li> <li class="last leaf"><a href="/products/isotype-controls" title="">Isotype Control Antibodies</a></li> </ul></li> <li class="expanded"><a href="/product-type/peptides-and-proteins" title="">Proteins and Peptides</a><ul class="menu"><li class="first leaf"><a href="/products/peptides-and-proteins" title="">Peptides & Proteins</a></li> <li class="leaf"><a href="/support/blocking-with-immunizing-peptide" title="">Blocking Peptides</a></li> <li class="last leaf"><a href="/product-type/peptides-and-proteins?applications=Bioactivity" title="">Biologically Active Proteins</a></li> </ul></li> <li class="last expanded"><a href="https://www.novusbio.com/product-type/lysates" title="">Lysates and Cell Lines</a><ul class="menu"><li class="first leaf"><a href="/product-type/lysates" title="">Lysates</a></li> <li class="last leaf"><a href="/research-areas/stem-cells/stem-cell-lines.html" title="">Stem Cell Lines</a></li> </ul></li> </ul></li> <li class="last expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first expanded"><a href="/product-type/kits" title="">Kits</a><ul class="menu"><li class="first leaf"><a href="/Lightning-Link%20Antibody%20Labeling%20Kits" title="">Antibody Labeling Kits</a></li> <li class="leaf"><a href="/product-type/kits?category=Kits&kit_type=ChIP%20Kit" title="">ChIP Kits</a></li> <li class="leaf"><a href="/products/elisa-kits" title="">ELISA Kits</a></li> <li class="last leaf"><a href="/product-type/kits?category=Kits&kit_type=Flow%20Cytometry%20Kit" title="">Flow Cytometry Kits</a></li> </ul></li> <li class="expanded"><a href="/product-type/support-products?category=Support%20Products&applications=Ligand%20Activation" title="">Activators and Inhibitors</a><ul class="menu"><li class="first leaf"><a href="/product-type/inhibitors" title="">Inhibitors</a></li> <li class="last leaf"><a href="/product-type/support-products?category=Support%20Products&applications=Ligand%20Activation" title="">Activators</a></li> </ul></li> <li class="expanded"><a href="/product-type/support-products" title="">Support Products</a><ul class="menu"><li class="first leaf"><a href="/research-topics/cell-biology/exosome-isolation-and-detection" title="Exosome Isolation and Detection Tools">Exosome Isolation</a></li> <li class="leaf"><a href="/products/flow-cytometry-quality-control-beads" title="Flow Cytometry Calibration, Compensation and Cell Counting Beads">Flow Cytometry Beads</a></li> <li class="leaf"><a href="/control-slides" title="">IHC Tissue Slides</a></li> <li class="leaf"><a href="/tissue-microarrays" title="">IHC Microarrays</a></li> <li class="leaf"><a href="/search?keywords=runblue" title="">Western Blot Gels & Buffers</a></li> <li class="leaf"><a href="/product-type/wb-membranes" title="">Western Blot Membranes</a></li> <li class="last leaf"><a href="/product-type/support-products" title="">All Support Products</a></li> </ul></li> <li class="last leaf"><a href="/support/bulk-and-custom.html" title="">Bulk and Custom</a></li> </ul></li> </ul><div class="clear"></div></div> </div></div> <div class="menu_header"> <a href="/search?keywords=novus" class="main_menu_parent_link">Products</a> </div> </li> <li class="main_menu_parent"> <div class="main_menu_submenu"><div id="menu_support" class="menu_drop"> <div class="mm_menu"><a href="/support/support-by-application.html"><div class="link_button link_protocols_button">Our Protocols</div></a><ul class="menu"><li class="first expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first last expanded"><a href="/support.html" title="">Resources</a><ul class="menu"><li class="first leaf"><a href="/support/support-by-application.html" title="">Protocols</a></li> <li class="leaf"><a href="/support/video-protocols" title="">Video Protocols</a></li> <li class="leaf"><a href="/support/troubleshooting" title="">Troubleshooting Guides</a></li> <li class="leaf"><a href="/mailing-list" title="">Posters and Literature</a></li> <li class="leaf"><a href="/support/handbooks-and-guides" title="">Handbooks and Guides</a></li> <li class="leaf"><a href="/resources/calculators" title="">Calculators</a></li> <li class="leaf"><a href="/support/faqs.html" title="">FAQs</a></li> <li class="leaf"><a href="/antibody-news" title="">Blogs</a></li> <li class="leaf"><a href="/all-diseases.html" title="">Diseases</a></li> <li class="leaf"><a href="/whitepapers.html" title="">Whitepapers</a></li> <li class="leaf"><a href="/webform/help-finding-antibodies" title="">Antibody Concierge</a></li> <li class="last leaf"><a href="/webinar" title="">Webinars</a></li> </ul></li> </ul></li> <li class="last expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first expanded"><a href="/research-tools.html" title="">Tools</a><ul class="menu"><li class="first leaf"><a href="/spectraviewer" title="">Spectra Viewer</a></li> <li class="last leaf"><a href="/novusknowsflow.html" title="">Flow Cytometry Panel Builder</a></li> </ul></li> <li class="expanded"><a href="/application" title="">Application</a><ul class="menu"><li class="first leaf"><a href="/application/elisa" title="">ELISA</a></li> <li class="leaf"><a href="/application/flow-cytometry" title="">Flow Cytometry</a></li> <li class="leaf"><a href="https://www.novusbio.com/products/antibodies-cytof" title="">Mass Cytometry (CyTOF)</a></li> <li class="leaf"><a href="/application/icc" title="">ICC</a></li> <li class="leaf"><a href="/application/ihc" title="">IHC</a></li> <li class="last leaf"><a href="/application/western-blotting" title="">Western Blotting</a></li> </ul></li> <li class="last expanded"><a href="/interviews" title="">Interviews</a><ul class="menu"><li class="first leaf"><a href="/faculty/faculty-interviews" title="">Faculty</a></li> <li class="last leaf"><a href="/postdoc/postdoc-interviews" title="">Postdoc</a></li> </ul></li> </ul></li> </ul><div class="clear"></div></div> </div></div> <div class="menu_header"> <a href="/support.html" class="main_menu_parent_link">Resources</a> </div> </li> <li class="main_menu_parent"> <div class="main_menu_submenu"><div id="menu_ra" class="menu_drop"> <div class="mm_menu"><a href="/pathwaypages.html"><div class="link_button">View Pathways</div></a><ul class="menu"><li class="first expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first last expanded"><a href="/research-areas.html" title="">By Research Area</a><ul class="menu"><li class="first leaf"><a href="/research-areas/apoptosis" title="">Apoptosis</a></li> <li class="leaf"><a href="/research-areas/autophagy" title="">Autophagy</a></li> <li class="leaf"><a href="/research-areas/cancer" title="">Cancer</a></li> <li class="leaf"><a href="/research-areas/cell-biology" title="">Cell Biology</a></li> <li class="leaf"><a href="/research-areas/cellular-markers" title="">Cellular Markers</a></li> <li class="leaf"><a href="/research-areas/epigenetics" title="">Epigenetics</a></li> <li class="leaf"><a href="/research-areas/epitope-tags" title="">Epitope Tags</a></li> <li class="leaf"><a href="/research-areas/cell-biology/Exosome-research-tools" title="Exosome Research Tools">Exosomes Research</a></li> <li class="leaf"><a href="/research-areas/hypoxia" title="">Hypoxia</a></li> <li class="leaf"><a href="/research-areas/immunology" title="">Immunology</a></li> <li class="leaf"><a href="/research-areas/microbiology" title="">Microbiology</a></li> <li class="leaf"><a href="/research-areas/neuroscience" title="">Neuroscience</a></li> <li class="last leaf"><a href="/research-areas/stem-cells" title="">Stem Cells</a></li> </ul></li> </ul></li> <li class="last expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first last expanded"><a href="/pathwaypages.html" title="">By Pathway</a><ul class="menu"><li class="first leaf"><a href="/akt-signaling-pathway" title="">AKT </a></li> <li class="leaf"><a href="/apoptosis-pathway" title="">Apoptosis</a></li> <li class="leaf"><a href="/autophagy-pathway" title="">Autophagy</a></li> <li class="leaf"><a href="/mapkerkpathway.html" title="">ERK1/2/5 Pathway</a></li> <li class="leaf"><a href="/hedgehogpathway.html" title="">Hedgehog</a></li> <li class="leaf"><a href="/hippo-pathway.html" title="">Hippo</a></li> <li class="leaf"><a href="/jnk-signaling-pathway" title="">JNK Pathway</a></li> <li class="leaf"><a href="/mtor-pathway" title="">mTOR</a></li> <li class="leaf"><a href="/necroptosis-pathway" title="">Necroptosis</a></li> <li class="leaf"><a href="/nfkbpathway" title="">NFKB Signaling</a></li> <li class="leaf"><a href="/p38mapkpathway.html" title="">p38 Signaling</a></li> <li class="leaf"><a href="/tgfbetapathway" title="">TGF Beta</a></li> <li class="last leaf"><a href="/toll-like-receptors" title="">TLR</a></li> </ul></li> </ul></li> </ul><div class="clear"></div></div> </div></div> <div class="menu_header"> <a href="/research-areas.html" class="main_menu_parent_link">Research Areas</a> </div> </li> <li class="main_menu_parent"> <div class="main_menu_submenu"><div id="menu_promotions" class="menu_drop"> <div class="mm_menu"><a href="/about/rewards.html"><div class="link_button">Get Rewards</div></a><ul class="menu"><li class="first last expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first last expanded"><a href="/programs.html" title="">Customer Care</a><ul class="menu"><li class="first leaf"><a href="/guarantee" title="">100% Guarantee</a></li> <li class="leaf"><a href="/support/innovators-reward.html" title="">Risk Free Testing</a></li> <li class="leaf"><a href="/about/rewards.html" title="">Novus Rewards Program</a></li> <li class="leaf"><a href="/publications" title="">Publication Rewards Program</a></li> <li class="leaf"><a href="/newlab.html" title="">New Lab Discount</a></li> <li class="leaf"><a href="/scholarship-program.html" title="">Scholarship</a></li> <li class="leaf"><a href="/travelgrant.html" title="">Travel Grants</a></li> <li class="last leaf"><a href="/products/promotions" title="">Promotions</a></li> </ul></li> </ul></li> </ul><div class="clear"></div></div> </div></div> <div class="menu_header"> <a href="/programs.html" class="main_menu_parent_link">Customer Care</a> </div> </li> <li class="main_menu_parent"> <div class="main_menu_submenu"><div id="menu_about" class="menu_drop"> <div class="mm_menu"><a href="/about/careers-at-novus.html"><div class="link_button">Novus Careers</div></a><ul class="menu"><li class="first last expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first last expanded"><a href="/about.html" title="">About us</a><ul class="menu"><li class="first leaf"><a href="https://www.bio-techne.com/about/careers" title="">Careers</a></li> <li class="leaf"><a href="/about/collaborations.html" title="">Collaborations</a></li> <li class="leaf"><a href="/about/events" title="Events">Events</a></li> <li class="leaf"><a href="/about/novus-story.html" title="">Novus Story</a></li> <li class="leaf"><a href="/about/novus-team.html" title="">Our Team</a></li> <li class="leaf"><a href="/about/novus-philanthropy.html" title="">Philanthropy</a></li> <li class="leaf"><a href="/about/press-release.html" title="">Press Releases</a></li> <li class="last leaf"><a href="/why-choose-novus.html" title="">Why choose Novus</a></li> </ul></li> </ul></li> </ul><div class="clear"></div></div> </div></div> <div class="menu_header"> <a href="/about.html" class="main_menu_parent_link">About Us</a> </div> </li> <li class="main_menu_parent"> <div class="main_menu_submenu"><div id="menu_contact" class="menu_drop"> <div class="mm_menu"><ul class="menu"><li class="first last expanded"><span title="" class="separator"><hr></span><ul class="menu"><li class="first last expanded"><a href="/about/contact-us.html" title="">Contact Us</a><ul class="menu"><li class="first leaf"><a href="/about/contact-us.html" title="">Customer Service</a></li> <li class="leaf"><a href="/novus-distributors/list" title="">Distributors</a></li> <li class="last leaf"><a href="/support/technical-support.html" title="">Technical Support</a></li> </ul></li> </ul></li> </ul><div class="clear"></div></div> </div></div> <div class="menu_header"> <a href="/about/contact-us.html" class="main_menu_parent_link">Contact</a> </div> </li> </ul> </div> </div> </div> </div> </div> </div> </div> <div id="caspertesting"> <div class="container_16"> <div id="page-breadcrumb" class="grid_16"> <div class="breadcrumb"><a href="/">Home</a> » <a href="/research-areas.html" title="">By Research Area</a> » Exosomes Research</div> </div> <div class="main grid_16">  <h1>Exosomes Research</h1> </div> <div class="clear"></div> <div class="grid_16"> <div class="region region-content"> <div id="block-et-messages-et-messages-block" class="block block-et-messages"> <div class="content"> <span></span> </div> </div> <div id="block-system-main" class="block block-system"> <div class="content"> <div id="node-12415696" class="node node-page clearfix"> <div class="content"> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><table cellpadding="6" cellspacing="6" border="0"> <tbody> <tr valign="top"> <td style="width:220px"> <p><strong><u>Related Links</u></strong></p> <p><a href="/research-areas/cell-biology/Exosome-research-tools">Exosome Research Tools</a></p> <p><a href="https://www.novusbio.com/research-topics/cell-biology/exosome-isolation-and-detection">Exosome Isolation and Detection</a></p> <p><a href="/research-areas/cell-biology/exosome-marker-antibodies">Exosome Marker Antibodies (CD63, CD81 and more)</a></p> <p><a href="/research-topics/cell-biology/exosome-biomarkers-disease">Exosome Biomarkers for Disease</a></p> <p><a href="/research-topics/cell-biology/extracellular-vesicle-flow-cytometry">Extracellular Vesicle Flow Cytometry</a></p>   <p><strong><u>Other Resources</u></strong></p> <p><a href="/support/support-by-application.html?utm_content=protocols">Protocols and Troubleshooting</a></p> <p><a href="https://www.youtube.com/watch?v=XHHtqm99coQ" target="_blank">Webinar – Flow Analysis of Extracellular Vesicles</a></p> <p><a href="https://www.bio-techne.com/resources/literature/genomic-profiling-liquid-biopsy-biomarkers" target="_blank">Liquid Biopsy-Based Biomarkers Whitepaper</a></p> <p> </p> </td> <td> <h2>What are exosomes?</h2> <p>Once thought to be carriers of unwanted cytosolic waste, extracellular vesicles (EVs) are now understood to be important mediators of intercellular communication under both physiological and pathological conditions. To emphasize the importance of EVs as intercellular messengers, it is worth noting that they have been observed in every Kingdom of life, from the smallest bacteria to every cell in the human body. Exosomes are the smallest EVs and are of particular interest in the tumor microenvironment (TME), where they have been shown to directly mediate angiogenesis, tumor metastasis, and immunosuppression.</p> <p>EVs can be categorized into three main groups based on size, biogenesis, and function:</p> <br/> <table cellpadding="6" cellspacing="6"> <tr bgcolor="#ffffff"> <td valign="top" width="15%"> <p> </p> </td> <td valign="bottom" width="24%" align="center"> <img src="https://images.novusbio.com/design/exosome_illustration_75x75.jpg" border="0"></a> </td> <td valign="bottom" width="24%" align="center"> <img src="https://images.novusbio.com/design/exosome_illustration_125x125_v2.jpg" border="0" width="100px"></a> </td> <td valign="bottom" width="24%" align="center"> <img src="https://images.novusbio.com/design/exosome_illustration_175x175_v2.jpg" border="0" width="125px"></a> </td> </tr> <tr bgcolor="#005F9E"> <td valign="top" width="15%"> <p> </p> </td> <td valign="top" width="24%" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Exosomes</span><br/> <span style="color: #FFFFFF;"> (small EVs)</span> </p> </td> <td width="24%" valign="top" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Microvesicles</span> <span style="color: #FFFFFF;"> (medium/large EVs)</span> </p> </td> <td valign="top" width="17%" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Apoptotic bodies</span> <br/><span style="color: #FFFFFF;"> (large EVs)</span> </p> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <strong>Size</strong> </td> <td> 30-150 nm </td> <td> 100-1000 nm </td> <td> Up to 5000 nm </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <strong>Biogenesis</strong> </td> <td> <a href="/research-areas/cellular-markers/endosome-markers" target="_blank">Endosomal</a> </td> <td> Budding </td> <td> <a href="/research-areas/apoptosis" target="_blank">Apoptosis</a> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <strong>Function</strong> </td> <td> Intercellular communication (varied) </td> <td> Intercellular communication (varied) </td> <td> Contain intracellular contents from apoptotic cells </td> </tr> </table> <p align="center"> <a href="/support/apoptosis-necroptosis-and-autophagy-poster">Request a copy of our Apoptosis, Necroptosis, and Autophagy Poster</a> </p> <br/> <p>In place of specific nomenclature relating to biogenesis (e.g. exosome, microvesicle, apoptotic body), the <a href="https://www.isev.org/" target="_blank">International Society of Extracellular Vesicles (ISEV)</a> recommends referring to EVs based on the following: </p> <br/> <table cellpadding="6" cellspacing="6"> <tr bgcolor="#005F9E"> <td valign="top" width="15%"> <p> </p> </td> <td valign="top" width="24%" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Physical Characteristics</span> </p> </td> <td width="24%" valign="top" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Biochemical Composition</span> </p> </td> <td valign="top" width="17%" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Origins</span> </p> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <strong>Description</strong> </td> <td> Size (small, medium/large) Density (low, medium, high) </td> <td> Specific protein, lipid, or genomic content </td> <td> Cell type, treatment conditions </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td> <strong>Examples</strong></td> <td> Small EVs (sEVs): <200 nm Medium/large EVs (m/lEVs): >200 nm </td> <td> <a href="/primary-antibodies/cd81">CD81+</a>, <a href="/primary-antibodies/CD9">CD9+</a>, <a href="https://www.novusbio.com/primary-antibodies/Annexin-V">Annexin V+</a>, <a href="/primary-antibodies/epcam-trop1">EpCAM+</a>, <a href="/search?keywords=egf%20r%20erbb1&category=Primary%20Antibodies">EGFR+</a>, miRNAs </td> <td> Neuronal, epithelial, tumor-derived, hypoxic </td> </tr> </table> <p>For example, if isolating EVs from <a href="https://www.novusbio.com/research-areas/hypoxia">hypoxia</a>-treated neurons using differential centrifugation and ultrafiltration, they would be “small hypoxic neuronal EVs.” The most stringent way to verify the endosomal nature of exosomes is visually by electron microscopy. </p> <br/> <h2>Exosome Biogenesis: How are they made?</h2> <div align="center"> <img src="https://images.novusbio.com/design/exosome_biogensis_Image_v3.jpg" border="0"></a> </div> <br/> <br/> <p>Exosomes are formed in the endosomal maturation pathway. Briefly, inward budding of endosomes into multivesicular bodies (MVBs) results in the formation of intraluminal vesicles (ILVs). MVBs are destined for one of two fates: degradation or release. MVBs destined for degradation will either (A) fuse directly with the <a href="/research-areas/cellular-markers/lysosome-markers">lysosome</a> or (B) fuse with an autophagosome during the process of <a href="/research-areas/autophagy/signaling-pathway">autophagy</a>. This "amphisome" (MVB plus autophagosome) finally fuses with the lysosome. Alternatively, MVBs destined for release, traffic to the plasma membrane. Upon fusion with the plasma membrane, ILVs are secreted as exosomes via exocytosis.” The rate at which exosomes are secreted varies depending on the cellular source, but certain pathologies, like <a href="/research-areas/cancer">cancer</a> or <a href="/research-areas/hypoxia">hypoxia</a>, can increase the rate of EV release.</p> <p>MVs, in contrast, are vesicles formed directly from the outward protrusions of the plasma membrane and involve cytoskeletal and membrane rearrangement. Both exosomes and MVs are actively secreted from live cells. Apoptotic bodies are unique EVs as they are only formed during programmed cell death, or <a href="/apoptosis-pathway">apoptosis</a>, and are rapidly phagocytosed by patrolling <a href="/research-areas/immunology/innate-immunity">macrophages</a>.</p> <br/> <h2>Exosome Function: What do they do?</h2> <p>EVs are secreted with a diverse array of cargo necessary for intercellular communication, both locally and in distant tissues. This cargo includes genetic information such as messenger RNA (mRNA), microRNA (miRNA), non-coding RNA (ncRNA), as well as lipids and many classes of proteins. Novus Biologicals has an extensive offering of <a href="/research-topics/cell-biology/exosome-marker-antibodies">antibodies to “essential” exosome markers</a>, as well as tissue and tumor-specific exosome markers validated for a range of applications including <a href="https://www.proteinsimple.com/simple_western_overview.html" target="_blank">Simple Western</a> and <a href="/product-type/primary-antibodies?applications=Flow%20Cytometry">Flow Cytometry</a>. </p> <p>Exosomes and MVs are actively released from many cell types including reticulocytes, lymphocytes, <a href="/research-area/Dendritic-Cell-Markers">dendritic cells</a>, <a href="/research-area/Fibroblast-Cell-Markers">fibroblasts</a>, <a href="/research-areas/cellular-markers/endothelial-cell-markers.html">endothelial cells</a>, and stem cells as part of a range of dynamic intercellular signaling processes. </p> <br/> <h3>Roles of Extracellular Vesicles</h3> <div align="center"> <a href="https://images.novusbio.com/design/DW_NB-Gut-brain-Graphics-02.jpg" target="blank"> <img src="https://images.novusbio.com/design/extracellular_vesicles_Image_v6.jpg" alt="" title="" border="0" usemap="#map2"></a> </div> <br/> <br/> <h2>The Future of Exosomes</h2> <p>The number of applications for exosomes is constantly increasing. In addition to their role as biomarkers for cancers and other diseases, their vesicular nature and wide range of functions make them attractive candidates for therapeutic delivery, regenerative medicine, and vaccine adjuvants.</p> <br/> <table border="1" cellpadding="6" cellspacing="6"> <tr bgcolor="#005F9E"> <td valign="top" width="13%" align="center"> <p><span style="color: #FFFFFF; font-weight: bold;">Biomarkers</span></p> </td> <td valign="top" width="15%" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Therapeutic Delivery</span> </p> </td> <td width="15%" valign="top" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Regenerative Medicine</span> </p> </td> <td valign="top" width="18%" align="center"> <p> <span style="color: #FFFFFF; font-weight: bold;">Vaccine Adjuvants</span> </p> </td> </tr> <tr style="border-bottom-style: solid; border-color:#005f9e; border-width: 1px;"> <td valign="top"> <p>Proteins and genetic markers found in exosomes can serve as <i>indicators of disease prognosis and progression.</i></p> <ul> <li>Cancer</li> <li>Cardiovascular Disease</li> <li>Diabetes Meletus</li> <li>Rheumatoid Arthritis</li> <li>Alzheimer's</li> <li>Parkinson's</li> </ul> </td> <td valign="top"> <p>Vesicles carrying small molecules can avoid some of the <i>pitfalls associated with therapeutic-delivery.</i></p> <ul> <li>Stable over long-distances</li> <li>Carriers of vaccine antigens (mRNA, DNA)</li> <li>Transport of water-soluble molecules</li> <li>Potential to cross membranes (Blood-Brain-Barrier)</li> </ul> </td> <td valign="top"> <p>Mesenchymal stem/stromal cell (MSC)-derived exosomes have potential to promote tissue repair and regeneration through angiogenesis and cell propagation in preclinical models of:</p> <ul> <li>Liver Disease</li> <li>Cardiac Disease</li> <li>Neuronal Disease</li> <li>Cartilage Repair</li> <li>Lung Fibrosis</li> </ul> </td> <td valign="top"> <p>Dendritic cell (DC) derived exosomes can carry peptide-loaded MHC II molecules and activation markers</p> <ul> <li>Smaller and less immunogenic than DC-based vaccine strategies</li> <br/> </ul> <p>EVs from pro-inflammatory macrophages can potentiate inflammation</p> </td> </tr> </table> <h3>References:</h3> <p>Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, <em>et al.</em> Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. <em>J Extracell Vesicles</em> 2018;<strong>7</strong>:. <a href="https://doi.org/10.1080/20013078.2018.1535750" target="_blank">https://doi.org/10.1080/20013078.2018.1535750</a>.</p> <p><br> Kowal J, Arras G, Colombo M, et al. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. <em>Proc Natl Acad Sci U S A</em>. 2016;113(8):E968-E977. <a href="https://doi.org/10.1073/pnas.1521230113" target="_blank">https://doi.org/10.1073/pnas.1521230113</a> <br> <br> Woith E, Fuhrmann G, Melzig MF. Extracellular Vesicles-Connecting Kingdoms. <em>Int J Mol Sci</em>. 2019;20(22):5695. Published 2019 Nov 14. <a href="https://doi.org/10.3390/ijms20225695" target="_blank">https://doi.org/10.3390/ijms20225695</a></p> <p><br> Van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. <em>Nat Rev Mol Cell Biol</em> 2018:213–28. <a href="https://doi.org/10.1038/nrm.2017.125" target="_blank">https://doi.org/10.1038/nrm.2017.125</a>.</p> <p><br> Jadli, A.S., Ballasy, N., Edalat, P. <em>et al.</em> Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake. <em>Mol Cell Biochem</em> <strong>467, </strong>77–94 (2020). <a href="https://doi.org/10.1007/s11010-020-03703-z" target="_blank">https://doi.org/10.1007/s11010-020-03703-z</a></p> <p><br> Bebelman MP, Smit MJ, Pegtel DM, Baglio SR. Biogenesis and function of extracellular vesicles in cancer. <em>Pharmacol Ther</em> 2018:1–11. <a href="https://doi.org/10.1016/j.pharmthera.2018.02.013" target="_blank">https://doi.org/10.1016/j.pharmthera.2018.02.013</a>.</p> <p><br> Nikfarjam S, Rezaie J, Zolbanin NM, Jafari R. Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine. <em>J Transl Med</em> 2020:449. <a href="https://doi.org/10.1186/s12967-020-02622-3" target="_blank">https://doi.org/10.1186/s12967-020-02622-3</a>.</p> <map name="map2"> <area shape="RECT" coords="146,355,261,380" href="/research-areas/microbiology" title="Exchange of Pathogenic Material"/> <area shape="RECT" coords="290,355,396,381" href="/hedgehogpathway.html" title="Development and Regeneration"/> <area shape="RECT" coords="387,298,486,324" href="/research-areas/stem-cells" title="Stemness and reprogramming"/> <area shape="RECT" coords="66,293,148,309" href="/research-areas/immunology/inflammation" title="Inflammation"/> <area shape="RECT" coords="42,73,156,99" href="/research-areas/immunology" title="Immune Activation Wound Healing"/> <area shape="RECT" coords="280,7,412,34" href="/research-areas/cancer/metastasis" title="Tumor Metastasis and Immunosuppression"/> <area shape="RECT" coords="148,8,249,33" href="/pathwaypages.html" title="Cell Metabolism and Signaling"/> <area shape="RECT" coords="438,172,544,213" href="/research-areas/neuroscience" title="Neural development and homeostasis"/> <area shape="RECT" coords="370,66,523,94" href="/research-areas/neuroscience/neurodegeneration" title="Neurodegenerative disease (Alzheimer's Parkinsons)"/> <area shape="RECT" coords="11,179,99,204" href="/search?keywords=cell%20adhesion&related_pathways=Cell%20Adhesion" title="Cell Adhession and Motility"/> </map> </tbody> </table></div></div></div> </div> </div> </div> </div> <div id="block-block-21" class="block block-block"> <div class="content">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> </div> </div> </div> </div> </div> <div id="novus_footer_line"></div>  </div> <div class="container_16"> <div id="footer"> <div class="grid_16 text_center"> <div class="fp_horzline"></div> </div> <div class="clear"></div> <div class="grid_16"> <table class="footer_boxes"> <tr> <th>Popular Products</th> <th>Company Information</th> <th>Support</th> <th>Stay Connected</th> </tr> <tr> <td> <ul class='links'><li><a href="/productsearch/novus">Antibodies</a></li><li><a href="/product-type/secondary-antibodies">Secondary Antibodies</a></li><li><a href="/product-type/isotype-controls">Isotype Controls</a></li><li><a href="/product-type/peptides-and-proteins">Proteins and Peptides</a></li><li><a href="/product-type/elisa-kits">ELISA Kits</a></li><li><a href="/samplesize">Sample Size</a></li><li><a href="https://www.novusbio.com/new-product-information-page.html">New Products</a></li> </ul> </td> <td> <ul class='links'><li><a href="/about.html">About Us</a></li><li><a href="https://www.bio-techne.com/about/careers">Careers</a></li><li><a href="/guarantee">Novus Guarantee</a></li><li><a href="/about/contact-us.html">Contact Us</a></li><li><a href="/about/novus-team.html">Our Team</a></li> </ul> </td> <td> <ul class='links'><li><a href="/support/technical-support.html">Technical Support</a></li><li><a href="/support/faqs.html">FAQs</a></li><li><a href="/webform/help-finding-antibodies">Help Finding Antibodies</a></li><li><a href="/support/support-by-application.html">Protocols</a></li> </ul> </td> <td id="footer_social_links"> </td> </tr> </table> </div> <div class="clear"></div> <div class="grid_16"> <div id="GTS_CONTAINER" style="float: right;margin-top: 10px;"></div> <div id="footer_officeinfo"> </div> <div class="fp_horzline"></div> <div class="footer_othersites"> <p>Visit our other sites</p> <a href="https://www.bio-techne.com/" target="_blank"><div class="fp_biotechne"></div></a> <a href="https://www.rndsystems.com/"><div class="fp_rnd"></div></a> <a href="https://www.novusbio.com/" target="_blank"><div class="fp_novus"></div></a> <a href="https://www.tocris.com/" target="_blank"><div class="fp_tocris"></div></a> <a href="https://www.bio-techne.com/brands/proteinsimple" target="_blank"><div class="fp_proteinSimple"></div></a> <a href="http://www.biospacific.com/" target="_blank"><div class="fp_biospacific"></div></a>  <a href="http://www.acdbio.com/" target="_blank"><div class="fp_acd"></div></a> <a href="https://www.rndheme.com/" target="_blank"><div class="fp_rndcc"></div></a> </div> <div class="text_center"> <div class="fp_horzline"></div> </div> <div class="copyright">©2025 Novus Biologicals, All Rights Reserved.</div> <div class="footer_legal"> <ul class="links"><li class="menu-47946 first"><a href="/support/customer-service/privacy-policy.html" title="">Privacy Policy</a></li> <li class="menu-47956"><a href="/novus-bio-sitemap.html" title="">Sitemap</a></li> <li class="menu-47951"><a href="/about/contact-us.html" title="">Contact Us</a></li> <li class="menu-47941 last"><a href="/support/customer-service/terms.html" title="">Terms & Conditions</a></li> </ul> </div> <div class="clear"></div> </div> </div> </div> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"76fb58fb05","applicationID":"788348554,30870807","transactionName":"YFdbZBFZXxdWAhAMVlkdeFMXUV4KGA8LAVxoQlhXBmdHDVIW","queueTime":22,"applicationTime":126,"atts":"TBBYEllDTBk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>